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133results about "Cell differentiation" patented technology
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Human cord blood as a source of neural tissue for repair of the brain and spinal cord
InactiveUS20020028510A1Easy to distinguishImprove neurological dysfunctionNervous disorderCell differentiationDiseaseCord blood stem cell
The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to treat neurodegenerative diseases of the brain and spinal cord.
Owner:SANERON CCEL THERAPEUTICS +1
Regeneration and augmentation of bone using mesenchymal stem cells
InactiveUS6863900B2Reduce functionReduce the numberBiocideBioreactor/fermenter combinationsMedicineBiopolymer
Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.
Owner:MESOBLAST INT
Method of altering cell properties by administering rna
InactiveUS20060247195A1Less activeMinimise and prevent riskCell differentiationGenetic material ingredientsRNA SequenceIn vivo
The invention relates to the alteration of cell properties using RNA molecules. In particular, it relates to the alteration of the ability of cells to mobilise, migrate, integrate, proliferate and / or differentiate. For example, it relates to the induction of differentiation of stem cells, including the acquisition of the ability to migrate, integrate, and proliferate. It also relates to the induction of in vivo stem cell mobilisation, migration, integration, proliferation and / or differentiation. Accordingly, it relates to the promotion of stem cell-mediated functional repair. The invention also relates to the reversal of differentiation of differentiated cells. All these effects may be effected by providing isolated RNA comprising a RNA sequence extractable from cells comprising the desired cell type(s) to a population of cells under conditions whereby the alteration of the cell property is achieved.
Owner:RIBOSTEM
Methods for rejuvenating cells in vitro and in vivo
Owner:HU JIFAN
Methods of cell-based technologies
The present disclosure features methods relating to conducting a stem cell technology business such as a regenerative medicine business based on induced pluripotent stem cells (iPSCs) and cells differentiated from iPSCs. The present disclosure also provides a database of iPSC-derived cells and methods of using the database for tracking customers and samples, as well as methods for marketing and running the business.
Owner:KYOTO UNIV
Transluminal application of adult stem cells for body organ tissue repair
InactiveUS7452532B2Improve pumping capacityEasy to implementBiocideCell differentiationBody organsTissue repair
A method for repairing tissue of a selected organ from among heart, brain, liver, pancreas, kidney, glands, and muscles in a patient's body. Adult stem cells that have the capability to repair tissue of the selected organ are recovered by harvesting from the patient's body. The harvested stem cells are then intraluminally applied through a designated natural body vessel. During the time the stem cells are being applied to the targeted tissue downstream, the designated vessel or duct is selectively occluded to increase concentration and pressure of the applied adult stem cells by the vessel.
Owner:SCICOTEC
Composite materials for controlled release of water soluble products
InactiveUS7211275B2Inhibits inflammatory and immune responsePowder deliveryFibrinogenControlled releaseWater soluble
Composite materials comprising a water-soluble compound adsorbed onto a basic inorganic material and a bio-degradable polymer which yields acidic degradation products, methods of producing same, and methods of use thereof are described, wherein the composite materials are designed so as to provide controlled release of the water soluble molecule.
Owner:MASSACHUSETTS INST OF TECH
Induction of Myocardial Cell From Mammalian Bone Marrow Cell or Cord Blood-Derived Cell and Fat Tissue
InactiveUS20070212676A1Improve securityEasy to getCell differentiationMicrobiological testing/measurementCord blood stem cellCardiac muscle
This invention provides a method for differentiating mammalian bone marrow cells or cord blood-derived cells into myocardial precursor cells and / or myocardial cells by culturing said bone marrow cells or cord blood-derived cells with cells isolated from mammalian fat tissues or a culture supernatant thereof.
Owner:JAPAN SCI & TECH CORP
Expansion and Differentiation of Mesenchymal Stem Cells
A cell culture system for expanding and differentiating mammalian mesenchymal stem cells to chondrocytes is provided. Said cell culture system comprises a subpopulation of isolated MSC selected for their expression of integrin alpha 10, as well as additives promoting expansion and differentiation to chondrocytes. Methods and uses of said expanded and differentiated cells with a chondrogen phenotype are also provided, as well as compositions comprising said expanded and differentiated chondrocyte cells.
Owner:XINTELA AB
Decellularization and recellularization of organs and tissues
ActiveCN101272815APharmaceutical delivery mechanismMammal material medical ingredientsDecellularizationSolid organ
Owner:RGT UNIV OF MINNESOTA
Harnessing Cell Dynamics to Engineer Materials
The invention features synthetic materials and methods for inducing cell behavior. Matrix materials induce cell differentiation and cell manipulation based on mechanical and physical characteristics of the materials rather than chemical characteristics.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
Cartilage and Bone Repair Composition
InactiveUS20080031915A1Promote bone formationPromote cartilage formationBiocidePeptide/protein ingredientsCollagen iWhole body
The invention relates to a cartilage and bone repair composition comprising a group of human mesenchymal stem cells that are differentiated to the chondro-osteogenic lineage, by means of the amplification thereof with human serum and a transforming growth factor-beta 1 with a molecular domain for binding to collagen I (TGF-β1-DUC) obtained in eukaryotic expression systems, and a biocompatible material which is absorbed by the cells thus treated. The inventive composition can be employed using implants in the area to be repaired or it can be employed directly by injecting the cells in suspension either at the site of the injury or into the systemic circulation for the widespread distribution thereof.
Owner:UNIV DE MALAGA
Method and instrumentation for control of stem cell injection into the body
InactiveUS20050226855A1Decreased cell growthSimple methodBiocideBalloon catheterLumen DiameterRepair tissue
A method is described for repairing tissue of a selected organ from among heart, brain, liver, pancreas, kidney, and glands in a patient's body. In the method, stem cells that have the capability to repair tissue of the selected organ are intraluminally applied through a designated natural body vessel or duct leading to a predetermined target site of the tissue of the selected organ to be repaired. The stem cells are delivered into the respective vessel or duct through a catheter having a proximal portion of relatively larger central lumen diameter and outer diameter, and a distal portion of relatively smaller central lumen diameter and outer diameter, the two portions being integral with one another so that stem cells delivered into the central lumen of the proximal portion will flow through and exit the central lumen of the distal portion, the lumen diameter and length of each of the two portions being selected to minimize the pressure drop across the catheter during flow of the stem cells.
Owner:SCICOTEC
Osteogenic and anti-adipogenic oxysterols
InactiveUS20090220562A1Inhibit osteoclastic bone resorptionIncrease differentiationBiocidePeptide/protein ingredientsBone Marrow Stromal CellAdipogenesis
The present invention discloses osteogenic and anti-adipogenic oxysterols. Agents and methods for protecting, blocking or rescuing marrow stromal cells from the inhibitory effects of oxidative stress on their osteoblastic cellular differentiation are disclosed. Exemplary agents include oxysterols alone or in synergistic combinations, as well as hedgehog or Wnt signaling activators. The synergistic effects of oxysterols and bone morphogenic proteins are also disclosed.
Owner:RGT UNIV OF CALIFORNIA
Adenoviral E1A/E1B complementing cell line
Owner:CELLS GENESYS INC
Methods of Reprogramming Animal Somatic Cells
InactiveUS20100167404A1Extend the lifespanExtending telomere lengthCell differentiationMicrobiological testing/measurementMammalEmbryo
This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
Owner:ADVANCED CELL TECH INC
Methods for Reprogramming Adult Somatic Cells and Uses Thereof
InactiveUS20100135970A1Easy to produceReduce probabilityBiocideGenetic material ingredientsSomatic cellSomatic portion
As described below, the present invention features methods for reprogramming somatic cells and related therapeutic compositions and methods.
Owner:STEWARD RES & SPECIALTY PROJECTS
Cell aggregate-hydrogel-polymer scaffold complex for cartilage regeneration, method for the preparation thereof and composition comprising the same
InactiveUS20100120149A1Increase flexibilityHigh mechanical strengthCell differentiationCulture processHydrogel matrixPolymer scaffold
The present invention relates to a cell aggregate-hydrogel-polymer scaffold complex useful for cartilage regeneration which has a structure in which cell aggregates of differentiated chondrocytes are evenly dispersed in a hydrogel matrix, and the resulting hydrogel matrix is immobilized onto the surface of a polymer scaffold while filling up the pores thereof. Since the cell aggregate-hydrogel-polymer scaffold complex according to the present invention can efficiently induce the regeneration of cartilage tissue similar to natural cartilage and retain high mechanical strength, flexibility, and uniform morphology during the cartilage regeneration, it can be effectively used as a cartilage therapeutic agent for the repair of cartilage defects and injuries.
Owner:KOREA INST OF SCI & TECH
Dynamic vibrational method and device for vocal fold tissue growth
InactiveUS20100291045A1Induced differentiationBioreactor/fermenter combinationsBiocideCultured cellBiology
Dynamic vibrational methods and devices for inducing differentiation of stem cells into vocal fold fibroblast-like cells or for generating vocal fold-like tissue from cultured cells. Also provided are matrices providing sustained release of growth factors, and bioreactors generating and delivering a high frequency vibration with in-plane shear stress to cultured cells.
Owner:UNIVERSITY OF DELAWARE
Method for producing induced pluripotent stem cells with high efficiency and induced poluripotent stem cells prouced thereby
ActiveUS20110256626A1Improve efficiencyPromote generationCell differentiationCulture processPresent methodSomatic cell
The present invention provides a method for producing customized pluripotent stem cells. Specifically, the present invention comprises following steps: extracting proteins from any of the dedifferentiated stem cells or induced pluripotent stem cells, the said dedifferentiated or pluripotent stem cells being prepared by any known method; introducing the protein extract into the adult somatic cells; and culturing the adult somatic cells to produce pluripotent stem cells having the same pluripotency as that of embryonic stem cells. In addition, pluripotent stem cells produced according to the present method and cell therapeutics comprising the same are provided. The method allows pluripotent stem cells to be produced very easily and at a significantly higher yield, compared to typical methods.
Owner:SEOUL NAT UNIV HOSPITAL
Cardiac muscle regeneration using mesenchymal stem cells
InactiveUS20070003530A1Shorten the timeEasy to convertBone marrow stroma cellsBiocideCardiac muscleMesenchymal stem cell
Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.
Owner:MESOBLAST INT
Titration of differentiation medium components
ActiveUS20120129211A1Improve efficiencyMass productionCell differentiationMicrobiological testing/measurementCell lineageCulture mediums
Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.
Owner:FUJIFILM CELLULAR DYNAMICS INC
Transcriptome Transfer Produces Cellular Phenotype Conversion
The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Stem Cells and Signals Developed for Use in Tissue and Organ Repair and Replacement
Methods and compositions for repairing tissue. Certain embodiments of the invention involve transdifferentiation of cells in a manner not heretofore provided for. One embodiment of the invention features methods for producing stem cells. These methods can involve exposing cells (e.g., human fibroblasts) to a processed or activated egg extract (e.g., activated egg extract); and culturing the cells for a period of time to become stem cells. A cell culture can be performed in two or three dimensions, so that organ tissue or whole organs may be produced, e.g., for transplantation. Another embodiment of the invention features methods for promoting wound healing by using signaling complexes.
Owner:TEI BIOSCI
Restoration of methylation states in cells
InactiveUS20060188986A1Easy to useHigh magnificationCell differentiationMicrobiological testing/measurementReprogrammingCell type
A method for altering a characteristic or state of a cell, or reprogramming a cell, comprising treating a first cell type with an agent capable of altering a characteristic or state in a cell or reprogramming a cell, and determining the degree of alteration of the treated cell by measuring the methylation signature within the genome of the treated cell, wherein a given methylation signature is indicative of an altered characteristic or state of the treated cell. The preferred substance for treating the first cell is a cellular extract, lysate or component from a second cell type, the second cell type having a desired characteristic, or being the desired cell type the first cell type is to be reprogrammed to. The examples show the methylation state of a fibroblast cell being reprogrammed to that of an immune system T cell.
Owner:HUMAN GENETIC SIGNATURES PTY LTD
Methods of Rejuvenating Cells In Vitro and In Vivo
The present invention provides methods for rejuvenating cells, tissues and the whole body. Also provided are rejuvenating buffers and agents as well as kits for rejuvenating cells. Also provided are methods for dedifferentiating somatic cells and differentiating the cells into other cell types.
Owner:HU JIFAN
Endothelial precursor cells for enhancing and restoring vascular function
InactiveUS7135171B2Reverses effectRestore angiogenesisBiocidePeptide/protein ingredientsBlood vesselVascular function
Owner:CORNELL RES FOUNDATION INC
Human cord blood as a source of neural tissue for repair of the brain and spinal cord
InactiveUS7160724B2Easy to distinguishImprove neurological dysfunctionNervous disorderCell differentiationDiseaseCord blood stem cell
Owner:SANERON CCEL THERAPEUTICS +1
Method of bone regeneration
InactiveUS20070160584A1Promote differentiationPromote regenerationBiocideCell differentiationBone defectBones regeneration
It is an object of the present invention to provide a method for effectively regenerating bone, and more specifically to provide a method for regenerating bone that is capable of treating patients suffering from bone defect or bone injury. The present invention provides a method for regenerating bone, which comprises culturing and / or transplanting mesenchymal cells in the coexistence of epithelial cells.
Owner:HITACHI MEDICAL CORP +1
Methods of regulating differentiation in stem cells
InactiveUS20050266553A1Inhibition of differentiationReduce differentiationCompound screeningOrganic active ingredientsClass iiiAgonist
The present invention provides methods, media and compositions capable of modulating the differentiation of stem cells. Applicants have discovered that agonists of lysophospholipid receptors and ligands of class III tyrosine kinase receptors are useful in preventing the spontaneous differentiation of stem cells. The ligands and agonists may be used alone, or in combination where they have a synergistic effect. Also provided are cells produced using the methods and media, and methods of treating stem cell related diseases using the compositions described herein. Methods of identifying compounds useful in finding other agents useful in the modulation of stem cell differentiation are also disclosed.
Owner:ES CELL INT
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