2results about How to "Induced differentiation" patented technology

The present application relates to Foskolin induced differentiation treatment of hepatocellular carcinoma. Specifically, the present application relates to a method and use of Forskolin for inducing differentiation of human malignant hepatocellular carcinoma, thereby being applied to the treatment of malignant solid tumors. The research of the present application shows that after treating hepatocellular carcinoma cells with exogenous addition of Forskolin for a period of time, the hepatocellular carcinoma cells can be effectively induced to differentiate, thereby providing a new drug for tumor induced differentiation treatment. The purpose of the present application is to provide the use of Forskolin and its derivatives for anti-hepatoma drugs.

An object of the present invention is to provide a cerebral organoid derived from a human pluripotent stem cell, a cell aggregate including a cerebral cortical cell, and a method for producing any of them, each being useful for regenerative therapy. The method of the present invention for producing a cerebral organoid is a method for producing a cerebral organoid from a pluripotent stem cell in the absence of a sustentacular cell, and comprises: (1) a step of culturing the pluripotent stem cell in a culture solution, wherein the culture solution is substantially free of bFGF and provokes substantially no TGFβ signal; and (2) a step of inducing the cell obtained in step (1) to differentiate into a neural cell.