42 results about "Barrier membrane" patented technology

The invention provides an injectable short-fiber-based hydrogel tissue repair material with an electric response characteristic as well as a preparation method and application thereof, and the injectable short-fiber-based hydrogel tissue repair material with the electric response characteristic is prepared by taking a natural polymer material loaded with bioactive factors as a core layer material and a biodegradable material as a shell layer material through a coaxial electrostatic spinning technology. The method comprises the following steps: preparing short fibers with a core-shell structure, uniformly mixing the short fibers with a hydrogel matrix, injecting and filling a tissue defect part, and carrying out ultraviolet curing to form the tissue repair material. The injectable short-fiber-based hydrogel tissue repair material with the electrical response characteristic provided by the invention has piezoelectric characteristic and injectable characteristic, can generate electrical response through mechanical stimulation so as to promote cell proliferation and tissue repair, and also has controllable drug release capacity and good mechanical adaptability; the method is suitable for application scenes of complex tissue damage repair such as diabetes infected wound repair, articular cartilage repair, oral barrier membrane repair, abdominal wall defect repair and the like.

The invention discloses an operation method for splitting an oral implant bone, which comprises the following steps of: preparing an ultrathin bone sheet of which the buccal side is less than 1mm, reserving physiological connection between periosteum and the bone sheet, and constructing a periosteum bone flap. The periosteum flap is of a natural barrier membrane structure, and integrates the function of a bone sheet rigid support and the semi-permeable membrane characteristic of the periosteum. The buccal ultrathin bone sheet is connected with the basal bone, is a rigid support structure, supports an osteogenesis space, and can provide bone marrow stroma cells to participate in bone defect repair. Physiological attachment of periosteum is not only a blood supply source of an inner side bone sheet, but also exerts the characteristics of a semi-permeable membrane, replaces an artificial barrier membrane to stop fiber tissue from growing in, and follows the PASS principle of the GBR technology, so that the operation risk is reduced, the use of the artificial barrier membrane is reduced, the adaptation disease of bone splitting is widened, the absorption of buccal side bones is reduced, and the bone splitting effect is improved. And the clinical effect of bone defect repair is improved.

The invention discloses a body temperature responsive wet adhesive as well as a preparation method and application thereof in bone defect repair, and belongs to the technical field of preparation of bone defect repair materials. Carbon-carbon double bonds in methoxyethyl acrylate (MEA), N-isopropylacrylamide (NIP) and acrylic acid (AA) are subjected to a free radical polymerization reaction to generate a polymer chain, and a cross-linking agent containing metal cations is added for cross-linking. The body temperature responsive wet adhesive has a good wet adhesion effect and the ability of improving the stability of bone meal, and can solve the technical problem of bone substitute displacement caused by unstable fixation of a barrier membrane.

The invention relates to the technical field of oral cavity barrier membrane manufacturing, and particularly provides a periodontal tissue regeneration barrier membrane generation method, device, medium and equipment, and the method can comprise the steps that bone defect three-dimensional data in a periodontal three-dimensional model of a target object is acquired, and the periodontal three-dimensional model comprises tooth data and bone defect area data; generating barrier membrane three-dimensional data covering a bone defect area corresponding to the bone defect three-dimensional data; converting the barrier film three-dimensional data into barrier film plane data; a barrier membrane guide plate corresponding to the barrier membrane plane data is generated, the barrier membrane guide plate is used for manufacturing a barrier membrane, and the barrier membrane covers the bone defect area of the target object. According to some embodiments of the invention, the precise barrier membrane guide plate can be intelligently generated, and digital support is provided for precise medical treatment.

The utility model discloses a membrane self-expansion stent thrombectomy catheter, which relates to the technical field of medical instruments and comprises a thrombectomy catheter and a conveying catheter, the thrombectomy catheter and the conveying catheter are both of bendable flexible structures, the conveying catheter can be movably sleeved outside the thrombectomy catheter, a membrane self-expansion stent is arranged at the head end of the thrombectomy catheter, and the membrane self-expansion stent is arranged at the tail end of the thrombectomy catheter. A barrier film is arranged outside the self-expansion stent with the film, the self-expansion stent with the film is of a net-shaped flexible cover body structure with one end connected with the thrombectomy catheter and the other end open, and the self-expansion stent with the film can be shrunk into the delivery catheter; the thrombectomy catheter and the conveying catheter are used in a matched mode, the self-expansion support with the film is arranged at the end of the thrombectomy catheter to be combined with the thrombectomy balloon to conduct thrombectomy operation, and minimally invasive and thorough thrombectomy is achieved under the condition that blood vessels are cut in an interventional mode instead of a surgical mode. Compared with traditional interventional thrombus suction, thrombus extraction is more thorough; compared with traditional surgical blood vessel incision thrombectomy, wounds and complications caused by surgical incision operation are avoided.

The utility model belongs to the technical field of termite killing devices, and particularly relates to a reservoir termite bionic barrier membrane type killing device which comprises a first trapping bin, a cleaning mechanism is arranged in the first trapping bin and comprises a scraping plate, the front side and the rear side of the scraping plate are both fixedly connected with sliding plates, and the sliding plates are arranged on the first trapping bin. A threaded hole is formed in the left side of the front sliding plate, a threaded rod is connected to the inner wall of the threaded hole in a threaded mode, and a motor is fixedly connected to the left side of the threaded rod. A sliding plate slides to drive a scraping plate to move to scrape termite corpses above a bionic screen membrane to a discharging hole, and then the termite corpses fall into a first collecting box to be collected, the range of a reservoir dam is wide, a traditional device needs to regularly and manually clean the corpses and replace medicine, efficiency is low, and cost is high, and according to the design, manual intervention is reduced through automatic cleaning of a cleaning mechanism; the method is especially suitable for remote areas or areas with complex terrains, and maintenance frequency is reduced.

The invention belongs to the technical field of biomedical materials, and particularly discloses a zinc-based alloy guided bone regeneration barrier membrane as well as a preparation method and application thereof. Based on Zn, Cu, Li and Mg element selection, by reasonably setting the proportion of each alloy component, the degradable zinc-based guided bone regeneration membrane which has excellent biocompatibility, proper degradation speed, mechanical property, bone healing promotion, bone regeneration capability and antibacterial property is preferably selected; and meanwhile, adverse effects on bone regeneration caused by over-high degradation rate of other metal films such as magnesium alloy and hydrogen generated in the release process of the metal films are also avoided. The Zn-2Cu-0.8 Li-0.2 Mg alloy film is optimally selected from the comprehensive aspects of degradation speed, mechanical property, biocompatibility, guided bone regeneration performance, antibacterial performance and the like, and a high-quality guided bone regeneration material is provided for repairing bone defects such as alveolar bones.

The invention discloses an exhaust connector and a liquid medicine infusion apparatus, and relates to the field of medical instruments, the exhaust connector comprises a tube body, a lower pad, a barrier film, an upper pad and a cover body which are sequentially distributed in the air circulation direction, the cover body is provided with an air hole for air circulation, the tube body is provided with a branch tube in the liquid medicine circulation direction, and the lower pad is rotatably provided with a shaft body; a plurality of blades corresponding to the branch pipes are arranged on the shaft body, a cleaning assembly corresponding to the lower pad is arranged on the shaft body, liquid medicine in the pipe body circulates, the shaft body rotates through the blades, and the cleaning assembly rotates on the lower pad. The blades in the pipe body can actively disturb a flow field and loosen bubbles attached to the pipe wall, and the blades rotate to synchronously drive the shaft body and the cleaning assembly to rotate, so that the cleaning assembly continuously scrapes blockages and colloidal layers on the surface of the lower pad, and exhaust failure caused by blockage is avoided; and meanwhile, the lower pad is used as a buffer layer to directly bear hydraulic impact from the liquid injection needle cylinder, so that the damage risk is reduced.

The application relates to a guided bone regeneration composite barrier membrane based on inverse chirality topological deformation and temperature-sensitive shape memory and a preparation method thereof, and belongs to the technical field of medical devices. The barrier membrane comprises a metal framework and a base film layer completely wrapping the metal framework, wherein the metal framework comprises a plurality of rows of first circular rings and second circular rings in staggered distribution, and the first circular ring and the adjacent second circular ring are connected with a connecting rod in tangential connection. The application realizes the synergistic treatment effects of minimally invasive implantation, in-situ self-expansion, nail-free soft anchoring and full degradation through a micro-nano immersion process and reverse thermodynamic programming.

1. Name of the product in this design: Barrier Membrane for Guided Bone Regeneration (I). 2. Purpose of this design: To guide the use of a barrier membrane in bone regeneration procedures. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: the front view. 5. This design is a two-dimensional product, so the left view is omitted; this design is a two-dimensional product, so the right view is omitted; this design is a two-dimensional product, so the top view is omitted; this design is a two-dimensional product, so the bottom view is omitted.

This invention belongs to the field of medical materials, specifically relating to a patterned bio-barrier membrane with self-adhesive function and its preparation method. The preparation method includes: dissolving the adhesive matrix in a buffer solution, then adding reactive amino acids and a stabilizer to obtain a first mixture; adding ethanol and a hydrophobic agent to the first mixture, and stirring under heating conditions to obtain a second mixture; adding a thickener, a calcium supplement, and a reinforcing agent to the second mixture, continuing stirring, and then adding a protein precipitation reagent to precipitate the mixture, obtaining a hydrogel; covering a collagen membrane with a patterned porous mold, and adding the hydrogel to allow it to flow into the pores and solidify. This invention achieves precise adhesive loading through patterned design, combining advantages such as simple operation, reliable fixation, good biocompatibility, and high osteogenic efficiency, effectively solving the barrier membrane fixation problem in GBR technology, and is suitable for bone defect treatment in dental implant prosthesis restoration.

The invention relates to an establishment method of a high-fat induced intestinal organ injury model and an injury intervention method for the model. The establishment method comprises the following steps: step A, preparation: preparing colon cells, PBMC cells and an organ-like culture chip for later use; step B, colon barrier construction: inoculating colon cells to the surface of a barrier membrane on the lower side of a culture chip by using an organoid culture chip to obtain a colon barrier model; step C, constructing a co-culture model, and inoculating PBMC cells to the basal side of the colon barrier on the basis of the colon barrier to obtain a human colon barrier-PBMC co-culture model; d, constructing a damage model, and performing damage treatment on the co-culture model by using a treating fluid to obtain the damage model; according to the invention, the barrier function organ-like chip is used, a human intestinal cell-PBMC co-culture model is formed by utilizing human intestinal organs and PBMC cells, and OXLDL / palmitic acid can play a role in an injured intestinal organ barrier model and form a high-fat induced intestinal organ injury model through the prepared injury treating fluid.

The invention relates to the field of biomedical materials, in particular to a composite material mixed scaffold for bone repair and a preparation method of the composite material mixed scaffold. The method comprises the following steps: (1) taking zinc-magnesium-based alloy powder as a raw material, and obtaining a zinc-magnesium alloy stent through selective laser melting method 3D printing; (2) carrying out ball-milling mixing on bioactive glass powder and the modified mullite whiskers to obtain mixed powder, carrying out 3D printing molding on the mixed powder, and filling a zinc-magnesium alloy stent with the molded mixed powder to obtain a composite stent material; and (3) dissolving silk fibroin and breviscapine in a solvent to prepare a spinning solution, carrying out electrostatic spinning on the surface of the composite scaffold material to obtain a silk fibroin barrier membrane, and washing and drying to obtain the silk fibroin barrier membrane. Compared with magnesium alloy, the composite material mixed scaffold has the advantages that the degradation speed is obviously reduced, effective osteogenesis space support is realized, and the composite material mixed scaffold has good biocompatibility and osteogenesis efficiency.

This invention discloses a barrier membrane for guiding bone regeneration and its preparation method, relating to the field of materials technology for guiding bone regeneration. The barrier membrane comprises a stacked nanowire functional layer and a barrier layer, wherein the nanowire functional layer includes a Cu-loaded surface. 2+ Sr 2+ The barrier membrane, doped with hydroxyapatite nanowires, comprises polylactic acid as the barrier layer. This invention provides a barrier membrane that combines sequential ion release, directional ion release, immune regulation, angiogenesis promotion, osteoproliferation, and antibacterial adhesion functions, adapting to the stage-specific needs of bone repair and guiding bone regeneration. This invention effectively solves the problems of existing barrier membranes, which only provide physical barrier function, lack biological activity, are difficult to actively promote bone regeneration, have a single mode of active metal ion release, are difficult to achieve sequential regulation, have a high risk of postoperative infection, exhibit disordered diffusion of active components, and have limited functionality.

The present invention relates to a U-shaped teeth whitening tray with an embedded skeleton, which has a U-shaped tray-like structure formed by an outer wall, a bottom wall, and an inner wall. The teeth tray sequentially comprises, from inside to outside, a whitening gel layer, a flexible skeleton structure, an adhesive gel layer, and a barrier film layer, wherein the whitening gel layer comprises a tooth bleaching agent, and the flexible skeleton structure is formed by embedding nonwoven fabrics in upper and lower wax base layers or silica gel layers prefabricated into specific traits. During the preparation of the teeth tray, the flexible skeleton structure is used as the core, and a whitening gel composition and an adhesive gel composition are applied on the top and bottom, respectively; after drying, a lamellar structure integrally formed by the whitening gel layer, the flexible skeleton structure, and the adhesive gel layer is formed; and then the barrier film layer is attached to an outer side of the gel adhesive layer.

The application discloses an intelligent oral cavity barrier film, a monitoring system and a method for bone combination state. The intelligent oral cavity barrier film comprises: a degradable metal layer configured to include an inductor coil, a first plate of a capacitor, and a porous support area integrally connected with the inductor coil; a dielectric polymer layer; a second plate of the capacitor separated from the first plate by the dielectric polymer layer; the inductor coil, the first plate of the capacitor, the second plate of the capacitor and the porous support area are integrally formed by laser cutting from a whole piece of the degradable metal layer; wherein the inductor coil, the first plate, the dielectric polymer layer and the second plate jointly constitute a passive LC resonance circuit; the quality factor Q of the LC resonance circuit is configured to change in response to the change of ion concentration in the environment around the dielectric polymer layer, and the bone combination state can be wirelessly monitored by an in-vitro reading device. The application has mechanical support and complete degradability, and reduces the risk of secondary surgery.

The utility model discloses an oral cavity bone increment operation barrier membrane nail planting fixing auxiliary device which comprises a handle portion, a fixing portion and a fixing portion. The bent clamping end comprises two arc-shaped cranks, the rear ends of the two cranks are connected with the front ends of the two grab handles through connecting pivots respectively, and separation and reunion of the two cranks are controlled through tightness clamping of the two grab handles; the sides, close to each other, of the front ends of the two cranks are detachably provided with the chuck parts used for clamping the barrier film in the folded state. According to the scheme, the barrier film is clamped and positioned through the modularized chuck part, the barrier film can be clamped and stabilized in a non-contact mode through operation optimization of the scissor-type and lever-type mechanical handles, and an unshielded nailing operation space can be provided; the problems that in a traditional oral cavity bone increment surgery, a membrane nail is difficult to fix and position, tired to operate and poor in adaptation are systematically solved.

The utility model discloses an oral cavity guided bone regeneration barrier membrane fixing nail which structurally comprises a top part, a rod part and a self-tapping part from top to bottom, the top part is of a cylinder-like structure, and the bottom surface of the top part is connected with the top end of the rod part; the rod part is of an inverted circular truncated cone structure, and the bottom end of the rod part is connected with the top end of the self-tapping part; the self-tapping part is formed by splicing an inverted circular truncated cone and an inverted cone, and self-tapping threads are arranged on the side face of the self-tapping part. The structure of the fixing nail has self-tapping performance, stress uniformization can be achieved during fixing, and the situation that the guided bone regeneration membrane is impacted and cracks are generated in the fixing process can be effectively prevented.

A biodegradable and biocompatible barrier membrane of piezoelectric nano composites of Metallic Oxide (MO) (e.g., Magnesium oxide, Zinc oxide and iron oxide)-PLLA (Poly-L-lactide), which can be subjected to acoustic pressure from ultrasound, to generate useful electrical charge for enhanced bone regeneration and enhanced antibacterial effects for guided bone regeneration to treat dental diseases, such as periodontitis.

A kind of degradable metal barrier film for alveolar ridge preservation, made of degradable metal, the degradable metal is magnesium-based or zinc-based or molybdenum-based degradable metal material;The degradable metal barrier film is in film or in net shape, the metal barrier film is flat structure or in arched structure.The degradable metal barrier film for alveolar ridge preservation of the application, the degradable metal system (magnesium-based / zinc-based / molybdenum-based) is applied to oral site preservation for the first time, realizes the integration of the triple function of "mechanical support, biodegradation, biological activity".The degradable metal barrier film can be used as the preparation of medical devices for alveolar ridge preservation.

A disinfecting cover for use in disinfecting a weight bearing upper surface of a resilient medical patient pressure redistribution support includes a thin barrier membrane drapable on top of the weight bearing upper surface of the resilient support, and a peripherally-extending edge terminating between the peripherally-extending side of the resilient support between the weight bearing upper surface and the bottom surface of the support. The thin barrier membrane comprises an anti-microbial disinfectant, and being non-fibrous, and impervious to the transfer of fluid from the first main surface to the second main surface. The thin barrier membrane comprises a thickness operable to maintain the weight distribution of a patient on the weight bearing upper surface of the resilient medical patient pressure redistribution support substantially the same compared to the weight distribution without the thin barrier membrane.

The present disclosure relates to a surgical drape (1) having a lateral extension (x) and a longitudinal extension (y), the surgical drape being divided in an upper region (2) for arrangement proximal a head of a patient during surgical procedure and a lower region (3) arranged proximal a surgical site of the patient, the upper region being divided in a first lateral section (2a), a central section (2b) and a second lateral section (2c), the surgical drape further comprising: - a surgeon facing barrier sheet (4) being essentially liquid impermeable and transparent, the surgeon facing barrier sheet extending over the first lateral section, the central section and the second lateral section of the upper region, - a patient facing sheet (5) being essentially opaque, the patent facing sheet extending over the central section of the upper region, - a fenestration (6) arranged in the lower region, the fenestration permitting access to the surgical site when the surgical drape covers a patient during surgical procedures, - a first and a second limb portion (7,8) arranged in the surgeon facing barrier sheet in the upper region of the surgical drape, wherein the surgeon facing barrier sheet extends beyond the patient facing sheet along a respective first and second longitudinal edge of the patient facing sheet in the upper region.

The application relates to a preparation method of a self-barrier oral bone powder and the preparation method, and relates to the technical field of medical treatment. The problems that there is no adhesion between particles in the existing GBR operation, the particles are relatively dispersed, are easy to be displaced, need to be combined with an oral repair film for joint use, and the operation requirement of a doctor is relatively high are solved. The preparation method comprises the following steps: mixing and ball milling calcium phosphate salt powder and photosensitive resin according to a proportion, and forming a slurry after the ball milling; printing a plurality of independent particles with a straight-through hole structure from the slurry through 3D printing technology; calcining the printed particles; mixing and loading the calcined particles and calcium sulfate hemihydrate powder into a booster with a porous filter head according to a proportion; and adding a liquid medium into the booster and uniformly mixing, so that a paste-shaped composite material which can be pushed out is prepared; the paste-shaped composite material has the effects of self-curing, forming a hard inorganic substance which cannot be moved, can act as a barrier film, is beneficial to cell ingrowth, and reduces the operation difficulty.

The present invention discloses a composite material for alveolar bone repair and a preparation method thereof; the composite material is composed of a dense layer having a soft tissue barrier function and a loose layer having a function of guiding bone tissue regeneration; wherein: the dense layer is a fiber membrane formed by stacking nanofibers, which is formed by electrostatic spinning of polyester medical polymer materials; the loose layer is a scaffold material for bone repair, which is formed by electrostatic spinning of a composite scaffold material; the composite scaffold material is bonded by nano-scale inorganic filling materials and polyester medical polymer materials. The composite material for alveolar bone repair provided by the present invention is formed by ultrasonic welding of a dense layer having a soft tissue barrier function and a loose layer guiding bone tissue regeneration; the present invention combines the soft tissue barrier membrane and bone filling material required for GBR technology into one, solving the problem that existing alveolar bone defect repair materials require the use of soft tissue barrier membranes and cannot provide independent bone formation space.

The invention discloses a titanium mesh reverse in-place guide plate and barrier membrane integrated forming and fixing method, and relates to the technical field of tooth treatment, and the method comprises the following steps: S1, data acquisition; s2, designing a titanium mesh; s3, a guide plate design stage and a barrier film template design stage; and S4, an intraoperative implementation stage: determining the covering range of the barrier membrane based on the titanium mesh designed before the operation, pre-cutting and forming, after cutting is completed, covering the corresponding side of the titanium mesh with the cut barrier membrane, and performing titanium mesh-barrier membrane integrated pre-fixation in the near, far, middle and root square areas of the barrier membrane and the titanium mesh through absorbable sutures. The titanium mesh can be accurately positioned, the operation process is simplified, the operation time is saved, and accurate covering of the barrier membrane is ensured.

This invention discloses a bio-barrier membrane with guided bone regeneration (GBR) function and its construction method, belonging to the technical field of bone tissue regeneration and repair materials. The bio-barrier membrane is a composite structure formed by a decellularized periosteum and an extracellular matrix (ECM) cross-linked layer. Specifically, it is prepared by in-situ cross-linking of the decellularized periosteum with an acidic ECM solution. This bio-barrier membrane is a bilayer composite membrane that mimics the natural periosteum, synergistically exerting barrier, osteoconduction, and osteoinduction effects, significantly improving bone repair and regeneration.

The present application relates to the field of medical devices, in particular to a blocking device, comprising a support body, the support body comprising a proximal end disc, a distal end disc, a waist connecting the proximal end disc and the distal end disc; wherein the support body is a wave-shaped or grid-shaped structure formed by fixing connection of a plurality of elastic support rods; the waist has a through hole penetrating in the axial direction; and a barrier body and a barrier membrane; the barrier body and the barrier membrane have flexibility or elasticity; the barrier membrane and the barrier body are connected by partial or complete non-sewing mode; wherein the barrier body covers the surface of the support rod; the barrier membrane covers or blocks the through hole, and the periphery of the barrier membrane is connected with the support body.

The present invention relates to the field of biomedical materials, and in particular to a composite material hybrid scaffold for bone repair and a preparation method thereof. The method comprises the following steps: (1) using zinc-magnesium alloy powder as raw material, obtaining a zinc-magnesium alloy scaffold by 3D printing using a selective laser melting method; (2) ball-milling and mixing bioactive glass powder and modified mullite whiskers to obtain a mixed powder, 3D printing the mixed powder into a shape, and filling the zinc-magnesium alloy scaffold to obtain a composite scaffold material; (3) dissolving silk fibroin and breviscapine in a solvent to prepare a spinning solution, electrospinning the surface of the composite scaffold material to obtain a silk fibroin barrier membrane, and washing and drying the membrane. The composite material hybrid scaffold obtained by the present invention has a significantly lower degradation rate than that of magnesium alloy, achieving effective bone formation space support, and has good biocompatibility and bone formation efficiency.