161 results about "Infected wound" patented technology

A method of treating tissue damage comprises applying a negative pressure to a wound sufficient in time and magnitude to promote tissue migration and thus facilitate closure of the wound. The method is applicable to wounds, burns, infected wounds, and live tissue attachments. A wound treatment apparatus is provided in which a fluid impermeable wound cover is sealed over a wound site. A screen in the form of an open-cell foam screen or a rigid porous screen is placed beneath the wound cover over the wound. A vacuum pump supplies suction within the wound cover over the treatment site.

A method of treating tissue damage comprises applying a negative pressure to a wound sufficient in time and magnitude to promote tissue migration and thus facilitate closure of the wound. The method is applicable to wounds, burns, infected wounds, and live tissue attachments. A wound treatment apparatus is provided in which a fluid impermeable wound cover is sealed over a wound site. A screen in the form of an open-cell foam screen or a rigid porous screen is placed beneath the wound cover over the wound. A vacuum pump supplies suction within the wound cover over the treatment site.

A method of treating tissue damage comprises applying a negative pressure to a wound sufficient in time and magnitude to promote tissue migration and thus facilitate closure of the wound. The method is applicable to wounds, burns, infected wounds, and live tissue attachments. A wound treatment apparatus is provided in which a fluid impermeable wound cover is sealed over a wound site. A screen in the form of an open-cell foam screen or a rigid porous screen is placed beneath the wound cover over the wound. A vacuum pump supplies suction within the wound cover over the treatment site.

There is disclosed a medical device for implantation that acts to prevent transmission of infectious agents. Specifically, the present invention provides implantable devices, such as catheters or living skin matrices or wound dressings, for insertion into various body cavities or over wound sites to confer to the site microbicidal or virucidal activity. Devices in the disclosure designed as vaginal inserts also exhibit contraceptive spermicidal activity. The coated devices or devices having the inventive polymeric material interspersed throughout are formed into appropriate shapes according to their contemplated uses (such as catheters or Foley catheters). Further, the present invention provides devices for providing therapeutic anti-microbial activity into an infected body cavity or on an infected wound site.

An apparatus and a method for the therapy of a range of dermatological conditions using precisely formulated gaseous milieus featuring the beneficial functions of oxygen and ozone. A range of clinical applications for this system include the therapy of gas gangrene, infected wounds, poorly healing wounds, war wounds, decubitus ulcers, dermatological conditions due to circulatory disorders, lymphatic diseases of the skin, fungal skin infections, burns, nail afflictions, radiodermatitis, parasitic skin infestations, and frostbite.

A silk protein membrane is described which is loaded with an antimicrobial compound and has a substantially non-granular ultrastructure which is (i) substantially devoid of micellar silk fibroin substructures and (ii) substantially devoid of pores when analysed by scanning electron microscopy at 0.2 μm resolution. The antimicrobial compound comprises, in one aspect of the invention, a host defense peptide. The silk protein membrane of the invention can be used in a method for the treatment of wounds and allows the wound dressing to be kept in place after removal of that wound dressing from a wound the wound has less than 105 colony forming units per gram. A method for manufacturing a wound dressing is also disclosed which comprises transferring a cast precursor material and optionally a host defense peptide, into a solid support and then drying the precursor material on the solid support to form a silk protein membrane for use as the wound dressing.

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and / or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.

The invention provides a collagen gel and a preparation method thereof. The collagen gel comprises collagen and an antibacterial agent, wherein the antibacterial agent is at least one of chitosan and nano silver. The collagen gel also comprises a preservative, a substrate, a dispersing agent, a film-forming agent and water; and 1g of gel comprises 0.5 to 8.0mg of collagen, 0.001 to 15mg of antibacterial agent, 1 to 50mg of preservative, 10 to 50mg of matrix, 50 to 100mg of dispersing agent, 1 to 10mg of film-forming agent, and the balance of water. The method for preparing the collagen gel comprises the following steps of: performing dispersion and dissolution on the substrate by adopting the dispersing agent under ten-thousand grade clean environment; adding the dispersing agent, the substrate, the preservative, the antibacterial agent, and collagen solution into a vacuum emulsified homogenizer one by one; after fully mixing, standing and defoaming, filling the product. The collagen gel is applied to various open wounds and infected wounds, lightens hyperpigmentation, has good effect of accelerating wound healing, and can maintain long-term anti-bacteria function.

The invention relates to a bio-derived material with high tissue compatibility and long acting anti-infection. The bio-derived material comprises the components of a cell-free matrix and absorbable anti-infective nanometer particles, wherein the amount of the absorbable anti-infective nanometer particles implanted into the cell-free matrix have the range of 100-1000 micrograms / cm<3> according to the content of the inorganic antibacterial agent. A preparation method of the bio-derived material comprises the following steps of: (1) preparing absorbable inorganic antibacterial agent nanometer particles; (2) carrying out cell-free modifying treatment on the bio-derived material; and (3) constructing a nanometer-modified bio-derived material by using a self-assembly technology. The bio-derivedmaterial has the advantages of directly contacting an abdominal cavity, long acting anti-infection, high tissue compatibility and strong ability to promote cell proliferation and can be used for contaminated wounds or infected wounds and the like; after implanted in vivo, the inorganic antibacterial nanometer particles burst a medicament within a short period (not more than 2 h) to quickly realize effective concentration so that the duration time of the effective blood concentration reaches 2 weeks to 3 months or even longer; and the invention has favorable application potential in the rehabilitation treatment of various tissue organs.

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and / or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.

The invention provides a conductive photo-thermal self-healing composite hydrogel dressing as well as a preparation method and application thereof.The preparation method comprises the following steps:grafting acrylic acid on chitosan to obtain an N-carboxyethyl chitosan polymer; the preparation method comprises the following steps: grafting p-hydroxybenzaldehyde on a triblock copolymer to obtainan aldehyde-terminated polymer (PF127-CHO); the preparation method comprises the following steps: preparing an aldehyde-terminated polymer into a solution, adding carbon nanotubes into the polymer solution, and carrying out ultrasonic treatment in an ice bath to obtain an aldehyde-terminated / carbon nanotube dispersion liquid; the preparation method comprises the following steps: preparing an N-carboxyethyl chitosan polymer into a solution, mixing the solution with an aldehyde group-terminated / carbon nanotube dispersion liquid, and carrying out mutual crosslinking at 20-45 DEG C for 5-400 seconds to obtain the conductive, adhesive, self-healing, photo-thermal and nano composite hydrogel. The hydrogel has excellent adhesion, self-healing, pH response, biocompatibility and hemostatic performance, can show a photo-thermal behavior after being exposed to a near-infrared (NIR) region, causes physical damage to bacteria, and has huge potential for treating infected wounds.

An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.

The invention belongs to the field of medical dressings, and particularly relates to color-developing medical dressing and a preparation method thereof. The preparation method comprises the following steps: taking TTC (Triphenyl Tetrazolium Chloride) as a color developing agent, mesoporous silica nanoparticles as a carrier and alginate and sodium carboxymethyl cellulose as spinning raw materials, preparing fiber containing color developing components through electrostatic spinning, and then preparing the fiber into the medical dressing containing the color developing components through a non-woven fabric technology. The color-developing medical dressing prepared by the preparation method has very good biological safety, and has an indicating function on a bacteria-infected wound; meanwhile, the color-developing medical dressing has very good liquid absorptivity, and is capable of absorbing leakage liquid of the wound and promoting the healing of the wound.

The invention relates to a multifunctional specific biological bondinghydrogel withshearing ratesensibility, a preparation method and application thereof in infected wound dressing. The multifunctional specific biological bonding hydrogel is prepared from an acrylic acid-acryloyl glycinamide copolymer and a polyhydric phenol compound, wherein the acrylic acid-acryloyl glycinamide copolymer is formed by copolymerization of an acrylic acid monomer and an acryloyl glycinamide monomer, and the polyhydric phenolcompound is crosslinked with the acrylic acid-acryloyl glycinamide copolymer through hydrogen bond interaction to form the multifunctional specific biological bondinghydrogel. The preparation method comprises the following steps: adding thepolyhydric phenol compound into theacrylic acid-acryloyl glycinamide copolymer; carrying out multiple hydrogen bond cross-linking among carboxyl of acrylic acid, phenolic hydroxyl of the polyhydric phenol compound, carboxyl of acryloyl glycinamideand amino of acryloyl glycinamide, and adjusting the hydrogen bond densityby changing the copolymerization ratio and the addition amount of the polyhydric phenol compound, so that the multifunctionalspecific biological bonding hydrogel which is high in strength, capable of specifically adhering to tissues and easy to replace can be obtained.

The invention relates to the technical field of medical glue and in particular relates to chitosan biological medical glue for promoting human epidermal growth and a preparation method of the biological medical glue. The chitosan biological medical glue comprises the following raw materials in parts by weight: 10-100g of modified chitosan, 4-20000mg of nano-silver, 1-80g of human-like collagen, 10-400g of glycerol, 0.0001-0.1g of epidermal growth factor, 0.1-200g of viscosity regulator, 0.5-4g of cross-linking agent and the balance of purified water. Main and auxiliary materials take a synergistic effect to form a drug delivering system with a slow release function, thereby improving the availability of active substances; the chitosan biological medical glue is attached close to the uneven wound surface, but the chitosan biological medical glue does not stick to the uneven wound surface. The chitosan biological medical glue is excellent in biocompatibility, strong in antisepsis and anti-inflammation, free of local stimulation and systemic adverse reaction, colorless and transparent, conducive to wound observation, capable of quickly promoting the repair of the wound surface, suppressing and reducing the generation of scar and widely applicable to the treatment of infected wound, operative incisions, all burns, scalds and wounds.

The invention discloses compositions and formulations for the treatment of clean or infected wounds, some of the inventive formulations can be used to reduce or eliminate microbial contamination from surfaces such as skin, and inanimate objects such as countertops, cooking utensils, medical devices, cookware, food, grooming aids and agricultural biocides, and the like. Some of these compositions and formulations are well suited for use in wound dressings. Some of the formulation can kill and / or inhibit the growth of pathogenic bacteria, fungi, spores and viruses. The formulations comprise a compound such as an osmoticum in high enough concentration to create an osmotic gradient and at least one compound that acts to comprise the integrity of a microorganism's membrane or cell wall. These formulations may optimally include at least one agent that thickens the formulations. In some aspects the formulation is in the form of an emulsion.

The present invention is directed toward a wound dressing comprising a foam body made of polyurethane material treated with a plurality of colored biocidal dyes with at least one of the dyes being gram positive and at least one of the dyes being gram negative to dye the body a distinct color. The body has at least one planar surface and ranges from about 1 mm to about 10 mm in thickness and has an outer film cover and border with a hydrogel adhesive secured to the body. The foam body changes color when placed in contact with an infected wound site.

The present invention relates to the field of traditional Chinese medicine, in particular to a plaster for the treatment of burns, scalds and infected wounds caused by various reasons and the preparation method. The present invention includes the following components: sophora japonical, membranous milkvetch root, bletilla striata, garden burnet root, ovientvine, Chinese arborvitae twig, sappan wood, diverse wormwood herb, gardenia jasminoides ellis, Chinese honeylocust spine, castor bean, frankincense, litharge, borneol, camphor and patchouli oil; the specific preparation steps are that: (1) soaking-the sophora japonical, membranous milkvetch root, bletilla striata, garden burnet root, ovientvine, Chinese arborvitae twig, sappan wood, diverse wormwood herb, gardenia jasminoides ellis, Chinese honeylocust spine, castor bean, frankincense and patchouli oil are weighed according to the mix ratio by weight and are placed into a jar for soaking for 7 days; (2) frying - the soaked medicines are placed into an iron pot for frying for 60 to 80 minutes; (3) oil refining - the medicine residues are removed, the oil refining is started, litharge is added after 60 to 90 minutes of the pot boiling, then the pot is removed from the fire till the litharge melts down; (4) cooling - when the medicines which are removed from the fire are cooled down to 60 to 80 DEG C, then the borneol and camphor which are ground into the fine powder are placed into the pot for even agitating; (5) soaking - the medicines which are removed from the pot are placed into the water for soaking for 24 hours for use.

The invention discloses a composite zinc silver antibacterial agent contained chitosan fiber dressing which comprises a dressing body and antibacterial active components attached to the dressing body. The dressing body is a wound dressing made of chitosan fibers, the antibacterial active components are made of raw materials comprising, by weight, 2-4 parts of composite zinc silver antibacterial agents, 90-95 parts of dispersing agents and 1-7 parts of suspending agents. The composite zinc silver antibacterial agent contained chitosan fiber dressing can be widely applied to treatment of infectious wounds, surgical incisions, surgical traumas, body surface ulcers and various burning and scalding wounds, anti-bacteria, bleeding stopping, anti-inflammation and deodorization functions are achieved, and antibacterial and growth promoting effect especially for the infected wounds with more percolate is more remarkable.

The invention relates to medical super-hydrophobic antibacterial dressing and a method for preparing the same, and relates to the field of medical products. The method for preparing the medical super-hydrophobic antibacterial dressing includes placing dressing in alkaline buffer solution with dopamine and preparing polydopamine-modified first dressing samples by the aid of self-polymerization of the dopamine; placing the first dressing samples in solution with fluorine modifiers, and carrying out reaction to obtain fluorine-embellished polydopamine-modified second dressing samples; placing thesecond dressing samples in silver ionic solution, and carrying out reaction so as to carry out reduction on silver ions on polydopamine to obtain silver nanometer particles. The medical super-hydrophobic antibacterial dressing and the method have the advantages that the medical super-hydrophobic antibacterial dressing can be easily and controllably operated, and the sterilization and anti-adhesion purposes can be achieved by the medical super-hydrophobic antibacterial dressing under the control of the method at different wound healing phases; the medical super-hydrophobic antibacterial dressing is excellent in hydrophobic property and antibacterial property and can be used as acute wound or infected wound dressing.

The invention relates to an infected wound ultraviolet sterilizing device, and belongs to the technical field of medical equipment. The infected wound ultraviolet sterilizing device comprises a device main body, an ultraviolet sterilization box and a comprehensive control box, wherein an input equipment supporting plate is arranged on the front side of the device main body; input equipment is arranged on the input equipment supporting plate; a mouse shelving groove is formed in the right side of the input equipment; an operating table is arranged on the upper side of the input equipment supporting plate; a power key is arranged on the operating table; an ultraviolet starting key is arranged on the right side of the power key; an intensity adjusting key is arranged on the right side of the ultraviolet starting key; a display screen base is arranged on the device main body and is connected with a display screen support; and the upper side of the display screen support is connected with an information display screen. The infected wound ultraviolet sterilization device is complete in function and convenient to use, is time-saving and labor-saving when used for sterilizing the wound of a patient, is scientific and convenient, safe and efficient, and is complete in function, and working difficulty of medical staff is reduced.

The present invention is directed toward a wound dressing comprising a foam body made of polyvinyl acetal material treated with a plurality of colored biocidal dyes with at least one of the dyes being gram positive and at least one of the dyes being gram negative to dye the body a distinct color. The body has at least one planar surface and ranges from about 1 mm to about 3 mm in thickness and has an outer adhesive section secured to the body. The body when placed in contact with an infected wound site changing color.

The invention relates to a preparation method of a self-healing, excellent elastic recovery and antibacterial hydrogel dressing, the hydrogel mainly comprises quaternized / N-methylacryloylated chitosan and four-arm benzaldehyde end-capped polyethylene glycol, and blue light irradiation is combined for further crosslinking to prepare the multifunctional hydrogel. The prepared hydrogel has self-healing performance (dynamic covalent bonds), excellent elastic recovery (carbon-carbon double bond crosslinking) and antibacterial performance (quaternary ammonium salt modification), is used for repairing and regenerating skin tissue defects, and has outstanding application prospects in the direction of infected wound healing dressings. According to the present invention, the material has characteristics of rapid self-healing ability, excellent elastic recovery, good mechanical strength, and excellent antibacterial ability. The hydrogel is simple in preparation and operation process and low in production cost, and can be used as an effective novel wound infection dressing in treatment of chronic infection wounds at joints.

The invention discloses a detachable multifunctional abdominal cavity drainage tube, wherein an outer catheter and an inner catheter of the drainage tube are soft plastic tubes, and the outer catheterand the inner catheter are matched and connected with an outer connection structure through an inner connection structure; when the patient is drained, the outer catheter and the inner catheter playa supporting role in combination, so as to avoid a situation that drainage cannot be performed due to squeezing the inner catheter. When the drainage catheter is blocked, the inner catheter can be removed from the outer catheter to avoid secondary puncture and alleviate the pain and burden of patients. The sealing plug of the water injection pipe on the external catheter can be connected with thesyringe after being removed, and can be used for endoluminal drug infusion treatment or irrigation. If negative pressure suction is required for the infected wound, the drainage bag valve can be turned off and the negative pressure extraction device is connected to the negative pressure tube of the inner catheter for negative pressure drainage. The drainage tube has the functions of blockage prevention, negative pressure suction, intracavity drug filling, etc., is convenient and reliable to implement, and has good market application value.

Abstract of Disclosure A composition for pharmaceutical products and cosmetic products contains IgY egg yolk antibodies of SPF hens and microalgae extracts from Spirulina species, Spirulina varieties, and Chlorella species. The composition can also contain oxytetracycline and preservatives or antioxidants. The composition prepared as a salve is used for healing infected wounds and for preventing the infection of wounds.

The invention discloses paste for removing blood stasis and necrotic and promoting granulation. The paste is made of rheum officinale, golden cypress, rehmannia rhizome, lithospermum, frankincense, myrrh, radix angelicae, sangusis draconis, borneol, white wax, sesame oil, and badger fat. The paste is used for various burns and scalds, infection and dehiscence of incisional wound, ulcer, ecthyma and bedsore, infections and unhealing wound due to various reasons (such as infected wound of diabetes, sinus tracts formed by scrofula, and skin and muscular tissue defect caused by various wounds.

The invention relates to the technical field of biomedical materials, in particular to a cascade enzyme-like nano system for promoting healing of diabetic wounds and a preparation method and application thereof. The nano system comprises metal oxide nano particles and glucose oxidase modified on the surface of metal oxide. Glucose oxidase is modified on the surfaces of metal oxide nano-particles to obtain a cascade enzyme-like nano material which is used for regulating the micro-environment of the diabetic infected wounds and promoting the wounds to heal quickly.

The invention relates to a preparation method of nano silver antiseptic dressing and simultaneously discloses an application of the antiseptic dressing. The preparation method comprises the steps that after base material is cut into certain shapes, 2 to 9 parts of the base material is soaked in 10 to 200 parts of nano silver solution at 3 to 90 DEG C, so as to obtain antiseptic dressing containing 10 to 1000 PPM nano silver solution, and then the antiseptic dressing is conducted to radiation sterilization through cobalt 60 to obtain the nano silver antiseptic dressing. The preparation method adopts soaking technology, ensures that the nano silver solution is sufficiently spread in the base material, and ensures that the antibacterial property of the nano silver solution is fully played, so that the base material has higher capability of killing or restraining pathogenic bacteria, and a better environment is created for rapid healing of a wound. Simultaneously, the prepared nano silver antiseptic dressing can promote tissue repair and regeneration, accelerates wound healing, and can be widely applicable to the treatment of infected wounds or operative incision.