319 results about "Wound infection" patented technology

The invention relates to an infectious bacterium detection method and system based on double effects of a reflection spectrum and autofluorescence, and belongs to the field of biomedical detection. The method comprises the following steps: acquiring hyperspectral images of different samples under different light sources; performing data preprocessing on the collected sample hyperspectral image, realizing pixel-level alignment of the dual-effect image based on feature matching and image registration, and constructing a data set; the method comprises the following steps: constructing a wound infection bacterium detection model based on double effects of a reflection spectrum and autofluorescence, and comprising a double-branch feature extraction module which comprises a reflection branch and a fluorescence branch which are respectively used for extracting reflection hyperspectral image features and fluorescence hyperspectral image features; the redundant feature screening module screens the features extracted by the reflection branch and the fluorescence branch through a channel attention mechanism; and the feature fusion module adopts a cross-branch cross attention mechanism to fuse the features of the double branches. According to the method, learning is carried out from two physicochemical characteristics, and the effectiveness and adaptability of the technology are improved.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a hydrogel wound dressing for promoting healing of infectious wounds. The hydrogel wound dressing is prepared from the following raw materials: oxidized methacrylic acid hyaluronic acid, waterborne polyurethane, polylysine, cannabidiol, neomycin sulfate and 2-roots alcohol. The invention also provides a preparation method of the hydrogel wound dressing and application of the hydrogel wound dressing in preparation of products for repairing infectious wounds. The wound dressing provided by the invention has a microporous structure, good biocompatibility and biodegradability, and can be used for stopping bleeding, reducing wound infection and promoting cell proliferation and wound healing.

The invention relates to the technical field of health risk assessment, in particular to an intelligent early warning system for postoperative infection risk of orthopedic trauma. The system comprises a data acquisition module for acquiring physiological feature data and biomarker data; the key monitoring and screening module screens key monitoring patients according to the continuous abnormal representation growth degree of the initial physiological signs; the infection risk assessment module obtains a marker level index by using the initial deviation level and the growth amplitude of the biomarker, and obtains a wound infection risk coefficient in combination with the prediction condition of historical biomarker data; and the early warning report generation module is used for dividing patient early warning levels according to the physiological parameter abnormality and the wound infection risk coefficient to generate a risk report. According to the method, the evaluation accuracy of postoperative infection is improved through the physiological sign abnormity continuity and the biomarker sudden increase and prediction trend, the subsequent early warning level and risk report generation are more reliable, and a more personalized and accurate treatment scheme can be provided for a patient.

The invention discloses an ultrashort-sequence antibacterial peptide rich in lysine and tryptophan, an antibacterial peptide hydrogel and application of the ultrashort-sequence antibacterial peptide and the antibacterial peptide hydrogel. The preparation method comprises the following steps: combining lysine and tryptophan to obtain polypeptide containing five or six amino acids; then amidation is carried out on the C terminal of the polypeptide, fatty acid chain modification is carried out on the N terminal and side chain amino groups, the ultra-short sequence antibacterial peptide rich in lysine and tryptophan is obtained, and the antibacterial peptide has broad-spectrum antibacterial activity for resisting gram-positive and gram-negative bacteria. An antibacterial peptide micelle self-assembly experiment shows that C12-2KW can be self-assembled into stable hydrogel in a 7.17 mu M PBS (Phosphate Buffer Solution), the hydrogel internally has a compact net-shaped structure, can completely cover the peritoneal injury surface and physically isolate the peritoneal injury surface from surrounding tissues, and has a good effect on treating wound infection caused by MRSA (Methicillin-Resistant Staphylococcus Aureus); meanwhile, the compound has the effect of resisting intestinal wall and abdominal wall adhesion after an operation, is low in toxicity, has a very good application prospect in the aspect of preparing clinical antibacterial drugs, and is expected to become a candidate drug of a novel antibiotic.

The invention discloses a gastric cancer postoperative chemotherapy dynamic intervention method and system based on time point matching, and relates to the technical field of postoperative intervention. Health state data of wearable medical equipment of a gastric cancer postoperative patient is collected; preliminarily dividing the stomach cancer postoperative chemotherapy cycle into a plurality of key physiological time points based on the symptom inflection points, and respectively matching an intervention core problem and a corresponding stomach cancer postoperative chemotherapy intervention scheme for the plurality of key physiological time points; and the postoperative intervention platform analyzes the time period health state data collected by the wearable medical equipment at set time intervals, analyzes the health state data to automatically identify gastric cancer postoperative symptom inflection points, and dynamically matches key physiological time points based on symptom inflection point results. The stomach cancer postoperative treatment disruption rate is reduced, the crisis inflection point recognition accuracy is greatly improved, and the bone marrow suppression early diagnosis rate is greatly improved; the early diagnosis rate of postoperative wound infection of gastric cancer is improved, unnecessary intervention is reduced, and crisis event treatment is accelerated.

The invention belongs to the field of hydrogel application, and discloses an MOF-based wound dressing and a preparation method thereof, and the MOF-based wound dressing is a composite material prepared by reaction of carrier hydrogel GHA (GelMA / HAMA) and Cu / ZIF-8-coated Cur antibacterial particles. The GHA hydrogel is formed by the cross-linking of methacrylated gelatin (GelMA) and methacrylated hyaluronic acid (HAMA). The invention further discloses a preparation method of the GHA hydrogel. The problems of wound infection, slow healing speed and the like caused by lack of controllable hygroscopicity, poor antibacterial property and the like of the existing wound dressing can be solved, and the wound dressing has biocompatibility, pH responsiveness and antibacterial property.

The invention discloses a hydrogel adhesive based on gelatin and a clay material and a preparation method of the hydrogel adhesive. The hydrogel adhesive at least comprises the following preparation raw materials: modified gelatin, a modified clay material and a thiolated cross-linking agent. The hydrogel adhesive prepared by the invention has an excellent tissue adhesion effect in a moist environment, can form gel within 30-60s, has flexibly adjustable adhesion performance, and can meet the application of various surgical scenes. The fibrin glue has the blood coagulation promoting effect, the hemostasis effect is better than that of traditional fibrin glue, the antibacterial effect is achieved, the risk of wound infection is reduced, meanwhile, good elasticity and toughness are achieved, the matching degree with tissue mechanical properties is high, and the fibrin glue cannot lose efficacy during cyclic compression. The biological compatibility is good, the anti-inflammatory and anti-oxidation effects are achieved, and wound healing and regeneration can be accelerated.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The invention relates to the technical field of medical detection and spectral analysis, and discloses a spectrum detection method for microorganisms on a wound surface based on knowledge data dual-drive envelope fusion. The method comprises the following steps: firstly, acquiring a multi-band near-infrared spectrum signal of a wound surface through a fiber optic spectrometer, and carrying out normalization and smooth filtering pretreatment; analyzing optical characteristic parameters based on a diffuse reflection theory model, constructing a knowledge-driven characteristic sample space, extracting spectral high-order characteristics by using a one-dimensional deep convolutional neural network, and constructing a data-driven characteristic sample space; then generating a grain envelope sample through a double-flow feature fusion mechanism; and finally, constructing a lightweight dual-task classification model based on the particle envelope sample, and realizing rapid detection of fungal infection of the wound surface and identification of seven common bacteria. According to the method, the interpretability, the recognition precision and the robustness of characteristic pathology are considered, and an efficient and reliable technical scheme is provided for early clinical diagnosis of wound infection.

The invention discloses a hydrogel wound dressing and a preparation method thereof, and belongs to the technical field of medical wound dressing preparation. The preparation method comprises the following steps: S1, preparing chitosan-silver nanoparticles CS-Ag; s2, preparing aminated chitosan-silver nano particles (CS-Ag-NH2), and preparing the chitosan-silver nano particles, s3, a hydrogel wound dressing CNF / CS-Ag-NH2 is prepared; the CNF is a carboxylated cellulose nanofiber. According to the prepared CNF / CS-Ag-NH2 hydrogel wound dressing, through the synergistic effect of the carboxylated cellulose nanofibers and the aminated chitosan-silver nanoparticles, the organic combination of the antibacterial property and the healing promoting property is realized; the hydrogel wound dressing not only can effectively control wound infection, but also can promote wound healing, and has a wide application prospect.

The invention discloses a biomedical polymer-based wound infection indicating dressing material as well as a preparation method and application thereof, and the dressing material is obtained by modifying a pH responsive dye, performing graft polymerization on the modified pH responsive dye, a cross-linking agent and hydrophilic monomer free radicals to form a hydrogel coating, and then wrapping the hydrogel coating on a biomedical polymer material. The material has a pH responsive infection indication function, can amplify a wound infection condition which is not easy to detect into a color change which is intuitive and distinguishable by naked eyes, can meet the requirement of monitoring the skin wound infection condition in actual clinical application, is beneficial to early detection of wound infection, and has a wide application prospect. And the preparation method can maintain the original texture of the biomedical polymer material to the greatest extent and reduce the risk of dye exudation, and the preparation process is conventional and easy to operate and has wide engineering prospects.

The special ointment for burns and scalds comprises the following substances in parts by weight: 20-30 parts of dragon's blood; 40-60 parts of rheum officinale; 4-6 parts of borneol; 80 to 120 parts of gypsum; and 120 to 180 parts of a greasy matrix. Compared with the prior art, the prepared special ointment for burns and scalds has the advantages of quick effect, quick wound healing, no need of binding, no need of hospitalization treatment for light and moderate burns and scalds which do not endanger life, simple operation, economy and applicability. And moreover, wound infection can be greatly reduced by using the product, and good news can be brought to burn and scald patients.

The invention discloses a method and system for predicting early infection of a child burn wound, and the method comprises the steps: S1, obtaining the information of the child burn wound, and monitoring the local temperature, pH value, specific inflammatory marker level and original data of pathogen nucleic acid of the burn wound; s2, generating a trend change comprehensive model by using a time sequence analysis algorithm; s3, key features are extracted through an adaptive feature selection technology trend change comprehensive model, and data dimensions are reduced; s4, adopting a transfer learning method to perform pre-training in the burn case as a risk assessment model, and utilizing the risk assessment model to generate an infection risk score; and S5, setting a risk threshold value, and when the infection risk score exceeds a preset threshold value, performing early warning, marking child wound infection, generating a detailed infection report, and performing targeted treatment. According to the method, the problem that a high-performance prediction model is difficult to directly construct due to relatively small child medical data volume and complexity is solved, and the ability of early infection recognition of children is improved.

The invention relates to the field of preparation of conductive hydrogel, in particular to a preparation method and application of a visual multifunctional ionic conductive hydrogel sensor. Polyvinyl alcohol and N-isopropylacrylamide are used as a double-network framework, acrylic acid and lithium chloride are used as functional fillers, and a chemical / physical cross-linking effect is formed through mechanical stirring, so that the visual multifunctional ionic conductive hydrogel sensor is constructed. The hydrogel has dual responsiveness to strain / temperature, when the hydrogel is used as a wearable strain sensor, the overall signal response is kept stable after the hydrogel is subjected to multiple cyclic stretching cycles, and the hydrogel can be used for detecting large-amplitude and fine movement of a human body and can be used as a wearable temperature sensor. Based on the color development characteristic of hydrogel along with temperature change, the hydrogel can be used as a visual color-changing sticker to give early warning for patients suffering from fever, inflammation and wound infection, and a traditional temperature measurement method is improved to a great extent.

The invention discloses oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel. The oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel is prepared from oxidized konjac glucomannan, hydrazide hyaluronic acid, neomycin sulfate, cannabidiol and 2-roots alcohol. The invention further provides a preparation method of the oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel and application of the oxidized konjac glucomannan and hydrazide hyaluronic acid composite hydrogel in preparation of hemostatic materials. The composite hydrogel disclosed by the invention has high adhesion and excellent antibacterial property, is suitable for various wounds, and has excellent effects of stopping bleeding, relieving pain, reducing wound infection and promoting wound healing.

The invention discloses a high-moisture-permeability hydrogel nursing patch and a preparation method thereof, and belongs to the technical field of medical supplies. Sodium alginate and gelatin are scientifically compounded to serve as a gel skeleton, functional components such as the aloe extract, the humectant and the penetration enhancer are supplemented, a stable three-dimensional network structure is constructed, the synergistic effect of multiple effects of moisturizing, resisting bacteria, promoting absorption of active ingredients and the like is achieved, and the synergistic improvement of high moisture permeability, antibacterial property and mechanical property of the product is achieved; the prepared nursing patch can quickly and largely absorb exudate at a wound, keep the wound clean and dry, reduce the risk of wound infection by absorbing the exudate, promote wound healing, effectively relieve skin surface wounds and scratches, and avoid skin infection and ulceration caused by the wounds.

The present application relates to a kind of carboxymethylated gellan gum composite hydrogel that can promote the preparation method of infectious skin wound healing, the present application will be a certain concentration of carboxymethylated gellan gum with the solution of active ion (Ca 2+ 、Cu 2+ 、Zn 2+ ) of proper proportion, using ion crosslinking method to prepare carboxymethylated gellan gum hydrogel.The prepared hydrogel has fast gelation, good injectability, self-healing, tissue adhesion performance and excellent bacteriostatic effect, and can effectively promote the healing of infected wound, has potential application prospect in the treatment of wound infection.

This invention discloses a time-division multiplexed dual-mode monitoring sensor for blood glucose and implanted wound infection, and its monitoring method. The sensor includes an electrically connected sensing unit and a detection unit. The sensing unit includes a three-electrode system of sensing electrodes, and the detection unit includes a chronoamperometry circuit for blood glucose measurement, an open-circuit voltage method circuit for wound pH measurement, a switching circuit, and a control module. The control module regulates the switching circuit, enabling the sensor to alternately perform blood glucose and implanted wound pH measurements in a time-division multiplexed manner. Based on the pH measurement data, the blood glucose measurement results can be dynamically calibrated, and an alarm is triggered when the wound infection level measured by the pH measurement data exceeds a preset threshold. This invention optimizes the combination relationship of the three-electrode system and the timing control of the detection modes, achieving simultaneous detection of two indicators without adding additional electrodes. This not only improves detection accuracy and wearing comfort but also simplifies the device structure and reduces costs, showing great application potential.

The present application relates to the technical field of medical materials, and discloses a medical sterilization fiber dressing and a preparation process thereof. The dressing comprises a functional substrate and an electrochemically active component. The functional substrate comprises cyclodextrin grafted chitosan and sodium alginate, and the electrochemically active component comprises zinc powder and copper powder. The dressing utilizes the zinc powder and copper powder to form a micro-battery in an electrolyte environment, releases zinc ions and generates a micro-electric field to kill bacteria. At the same time, the cavity structure of the cyclodextrin grafted chitosan specifically recognizes and includes wound infection markers, and then regulates the reaction rate of the micro-battery, so as to realize the on-demand release of sterilization activity. The preparation process comprises the following steps: mixing the components to prepare a spinning solution, forming in a calcium chloride solution through wet spinning, and then stretching and drying to obtain the fiber dressing. The dressing can respond to the wound infection state, realize on-demand sterilization, and has good biocompatibility.

The present invention relates to the technical field of medical devices, and particularly relates to a portable wound treatment and cleaning device for general surgery, which includes a support block for fitting to the skin. A number of mounting blocks are slidably fitted on the top of the support block. A ball screw mechanism for driving the movement of the mounting blocks is provided on the mounting blocks. A pressing mechanism for flushing the wound is slidably fitted at the bottom of the mounting block; one end of the pressing mechanism away from the mounting block is hinged with a contact block. An infrared temperature sensor for measuring the skin temperature is fixedly connected to the bottom of the contact block. The infrared temperature sensor is electrically connected to a control panel for distinguishing normal skin and the wound area based on the skin temperature. The control panel controls the ball screw mechanism based on the skin temperature to drive the pressing mechanism to contact the wound area; a spraying mechanism for spraying disinfectant on the wound area is provided at the bottom of the contact block. Compared with the prior art, the present invention can replace manual cleaning and disinfection of wounds, improve the treatment efficiency, and reduce the probability of wound infection.

The present application relates to the technical field of biological materials, in particular to a light-responsive drug gel carrier and a preparation method thereof, in order to improve the controlled release function of the hydrogel material, the methyl methacrylate nitrobenzene compound containing nitrobenzene structure, hydantoin structure and propylene structure is prepared first, under the action of a photoinitiator, the double bond is crosslinked with methyl methacrylate and ethylene glycol methacrylate to form a hydrophilic gel network, so that the drug gel carrier is obtained; wherein the nitrobenzene structure has photosensitivity, and the crosslinking structure will be broken under ultraviolet irradiation, thereby reducing the stability of the gel material, destroying the rearrangement of the gel micelle structure, and realizing the release of the loaded drug; and the hydantoin structure introduced in the methyl methacrylate nitrobenzene compound also has good antibacterial performance, which can effectively avoid wound infection and improve wound recovery.

The invention provides a bone transport instrument, which comprises a head end fixer, a bone transport device, a bone transport device, a bone transport device and a bone transport device, and is characterized in that the head end fixer comprises a hydraulic cylinder; the guide rod is connected with a middle fixing device; the propeller is connected to the hydraulic cylinder of the head end fixer through a guide pipe; the two ends of the guide rod are connected with the head end fixers, and the guide rod is inserted into the hydraulic cylinder to form a hydraulic rod together with the hydraulic cylinder; the hydraulic cylinders at the two ends of the guide rod are connected to the two ends of the propeller through guide pipes correspondingly, and the propeller pumps hydraulic oil into the hydraulic cylinders through the guide pipes to push the guide rod to move. According to the internal traction mode, traction force does not need to be applied through an external fixing frame any more, it is avoided that too many kirschner wires are driven into limbs of a patient to fix sclerotin, the burden of the patient is relieved, wounds caused to the patient in the bone moving process are reduced, and therefore complications such as wound infection are further reduced.

The invention relates to the technical field of medical application, and particularly discloses a wound infection temperature-sensitive measuring application with a temperature monitoring function, which comprises an application layer, and the application layer is applied to a wound; a body temperature sensing layer or a smell sensing layer is arranged in the wireless sensor; the application layer is provided with the clamping shell, and the wireless sensor or the body temperature wireless sensor is connected with the application layer through the clamping shell, so that the wireless sensor or the body temperature wireless sensor detects the temperature or smell of the wound surface; the wireless temperature sensing and long-distance nursing system achieves the effects of wireless temperature sensing and long-distance nursing, continuously monitors the wound of a patient, sends out an inflammation warning when the wound temperature is increased when the patient is infected, uploads monitoring information to a hospital far-end system, analyzes inflammation and infection condition tracking, reminds the patient to change medicine in time, and improves the nursing efficiency. Therefore, the situation that the recovery period is affected due to the fact that wounds of patients are inflamed and dressing change is not conducted in time is reduced.

The invention provides a rhizoma bletillae composition as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The core effective component of rhizoma bletillae is rhizoma bletillae polysaccharide, the rhizoma bletillae polysaccharide has the effects of film forming, hemostasis, targeted wound repair promotion and infection prevention, tea polyphenol and rhizoma bletillae are compounded for use, the tea polyphenol and rhizoma bletillae synergistically resist inflammation, the expression quantity of proinflammatory factors IL-1beta, TNF-alpha and IL-6 is reduced by inhibiting NF-kappa B and MAPK signal channels, the inflammatory cascade reaction is remarkably blocked, and the anti-inflammatory effect is achieved. Red, swollen and pain caused by inflammation are effectively relieved, and wound healing is accelerated. In addition, the rhizoma bletillae and the tea polyphenol can also generate a synergistic antibacterial effect, and compared with a single rhizoma bletillae component, the probability of wound infection is further reduced; the compounding use of the rhizoma bletillae and the tea polyphenol also inhibits the excessive deposition of collagen, reduces the scar area, reduces the scar hyperplasia degree, and makes up the blank of only promoting healing and not preventing scars for burns and scalds in the prior art.

According to the suture-free band-aid, one end of a zipper rod penetrates through the inner side of a clamping base, then the zipper rod continues to be pulled to enable second allergy-free adhesive tape to move towards first allergy-free adhesive tape, and at the moment, the second allergy-free adhesive tape drives one side of a wound to be attached to the wound on one side of the first allergy-free adhesive tape; meanwhile, due to the fact that in the pulling process of the zipper rod, the clamping base locks the zipper rod to retract, the positions of the first allergy-free patch and the second allergy-free patch are fixed, the wound is squeezed to be kept in the attached state, suture-free treatment on the shallow wound is achieved, the risk that the wound is infected due to the fact that a traditional band-aid cannot suture the wound is avoided, and the wound healing efficiency is improved. Meanwhile, the dustproof plate is rotated to be clamped on the zipper rod, at the moment, the dustproof plate can prevent dust from falling into the wound, meanwhile, the wound can be prevented from being directly hit by other objects, and ventilation of the wound can be guaranteed through the ventilation grooves.

The present invention discloses a novel composite multi-layer breathable gauze material with both waterproof and anti-infection functions and a preparation method thereof. The specific preparation steps are: 1) the gauze is immersed in a graphene oxide solution, then rinsed and dried; a first layer of strengthening layer structure is formed on the surface of the gauze; 2) the gauze forming the first layer of strengthening layer structure is immersed in a stearic acid / organic silicon emulsion / vegetable oil mixed solution for hydrophobic modification to form a second layer of waterproof layer structure; 3) cold gas dynamic spraying is performed on the surface of the gauze to deposit nano silver particles to form a third layer of antibacterial layer structure; 4) it is light-proof packaged and irradiated and sterilized to obtain a novel composite multi-layer breathable gauze material with both waterproof and anti-infection functions, and the side with the silver coating is in direct contact with the wound during use. The gauze material of the present invention can achieve efficient prevention and treatment of wound infection, and the hydrophobic coating can effectively block external water and ensure breathability, which has important clinical significance for wound treatment.

The invention relates to the technical field of medical materials, and discloses a chitosan-based antibacterial dressing and a preparation method thereof. The antibacterial dressing comprises an adhesive tape layer, a dressing surface layer and a protective film, functional dressing liquid is adsorbed on the dressing surface layer, and the functional dressing liquid is prepared from, by weight, 2-4 parts of propolis extract, 1-3 parts of glycerinum, 1-3 parts of alginate oligosaccharide, 0.5-1 part of carbomer, 0.001-0.005 part of growth factors, 2-4 parts of modified chitosan and 3-6 parts of modified gelatin. The modified chitosan is grafted with borneol base and long-chain pyridinium salt, so that reproduction of common pathogenic bacteria can be efficiently and continuously inhibited, and wound infection is prevented; the modified gelatin can shorten the bleeding time of the wound surface and reduce the bleeding amount, and the dressing has good biocompatibility and biodegradability.

The present application relates to the technical field of medical bandage, and discloses a biomass antibacterial hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite antibacterial functional layer loaded thereon, the functional layer is composed of a composite antibacterial unit and lysozyme, and the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol sustained-release shell and an enzymatic cellulose scaffold.The present application forms a biomass antibacterial hemostatic bandage with broad-spectrum, long-acting, low drug resistance and hemostatic function by constructing a cationic antibacterial core-polyphenol sustained-release shell-enzymatic cellulose scaffold composite antibacterial unit and synergistically loading lysozyme.The bandage shows significant technical advantages in dealing with complex wound infection, especially gram-negative bacterial infection and drug-resistant bacterial challenge, and provides an efficient and safe solution for clinical wound management, and has important clinical application value and broad market prospect.