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133 results about "Wound infection" patented technology

Wound surface microorganism detection method based on optical fiber spectrum knowledge data dual-drive envelope

The invention relates to the technical field of medical detection and spectral analysis, and discloses a spectrum detection method for microorganisms on a wound surface based on knowledge data dual-drive envelope fusion. The method comprises the following steps: firstly, acquiring a multi-band near-infrared spectrum signal of a wound surface through a fiber optic spectrometer, and carrying out normalization and smooth filtering pretreatment; analyzing optical characteristic parameters based on a diffuse reflection theory model, constructing a knowledge-driven characteristic sample space, extracting spectral high-order characteristics by using a one-dimensional deep convolutional neural network, and constructing a data-driven characteristic sample space; then generating a grain envelope sample through a double-flow feature fusion mechanism; and finally, constructing a lightweight dual-task classification model based on the particle envelope sample, and realizing rapid detection of fungal infection of the wound surface and identification of seven common bacteria. According to the method, the interpretability, the recognition precision and the robustness of characteristic pathology are considered, and an efficient and reliable technical scheme is provided for early clinical diagnosis of wound infection.
Owner:SHENZHEN SECOND PEOPLES HOSPITAL (SHENZHEN INST OF TRANSLATIONAL MEDICINE)

A light-responsive drug gel carrier and a preparation method thereof

The present application relates to the technical field of biological materials, in particular to a light-responsive drug gel carrier and a preparation method thereof, in order to improve the controlled release function of the hydrogel material, the methyl methacrylate nitrobenzene compound containing nitrobenzene structure, hydantoin structure and propylene structure is prepared first, under the action of a photoinitiator, the double bond is crosslinked with methyl methacrylate and ethylene glycol methacrylate to form a hydrophilic gel network, so that the drug gel carrier is obtained; wherein the nitrobenzene structure has photosensitivity, and the crosslinking structure will be broken under ultraviolet irradiation, thereby reducing the stability of the gel material, destroying the rearrangement of the gel micelle structure, and realizing the release of the loaded drug; and the hydantoin structure introduced in the methyl methacrylate nitrobenzene compound also has good antibacterial performance, which can effectively avoid wound infection and improve wound recovery.
Owner:WENZHOU MEDICAL UNIV CIXI INST OF BIOMEDICINE

Rhizoma bletillae composition as well as preparation method and application thereof

PendingCN121971555AInhibit excessive depositionreduce expressionOrganic active ingredientsAntibacterial agentsInflammatory factorsBletilla striata
The invention provides a rhizoma bletillae composition as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The core effective component of rhizoma bletillae is rhizoma bletillae polysaccharide, the rhizoma bletillae polysaccharide has the effects of film forming, hemostasis, targeted wound repair promotion and infection prevention, tea polyphenol and rhizoma bletillae are compounded for use, the tea polyphenol and rhizoma bletillae synergistically resist inflammation, the expression quantity of proinflammatory factors IL-1beta, TNF-alpha and IL-6 is reduced by inhibiting NF-kappa B and MAPK signal channels, the inflammatory cascade reaction is remarkably blocked, and the anti-inflammatory effect is achieved. Red, swollen and pain caused by inflammation are effectively relieved, and wound healing is accelerated. In addition, the rhizoma bletillae and the tea polyphenol can also generate a synergistic antibacterial effect, and compared with a single rhizoma bletillae component, the probability of wound infection is further reduced; the compounding use of the rhizoma bletillae and the tea polyphenol also inhibits the excessive deposition of collagen, reduces the scar area, reduces the scar hyperplasia degree, and makes up the blank of only promoting healing and not preventing scars for burns and scalds in the prior art.
Owner:ZUNYI MEDICAL UNIVERSITY

Chitosan-based antibacterial dressing and preparation method thereof

PendingCN121287983AAbsorbent padsBandagesPropolisBleeding time
The invention relates to the technical field of medical materials, and discloses a chitosan-based antibacterial dressing and a preparation method thereof. The antibacterial dressing comprises an adhesive tape layer, a dressing surface layer and a protective film, functional dressing liquid is adsorbed on the dressing surface layer, and the functional dressing liquid is prepared from, by weight, 2-4 parts of propolis extract, 1-3 parts of glycerinum, 1-3 parts of alginate oligosaccharide, 0.5-1 part of carbomer, 0.001-0.005 part of growth factors, 2-4 parts of modified chitosan and 3-6 parts of modified gelatin. The modified chitosan is grafted with borneol base and long-chain pyridinium salt, so that reproduction of common pathogenic bacteria can be efficiently and continuously inhibited, and wound infection is prevented; the modified gelatin can shorten the bleeding time of the wound surface and reduce the bleeding amount, and the dressing has good biocompatibility and biodegradability.
Owner:YANGZHOU POLYTECHNIC INST

Biomass antibacterial hemostatic bandage and functionalization method thereof

The present application relates to the technical field of medical bandage, and discloses a biomass antibacterial hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite antibacterial functional layer loaded thereon, the functional layer is composed of a composite antibacterial unit and lysozyme, and the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol sustained-release shell and an enzymatic cellulose scaffold.The present application forms a biomass antibacterial hemostatic bandage with broad-spectrum, long-acting, low drug resistance and hemostatic function by constructing a cationic antibacterial core-polyphenol sustained-release shell-enzymatic cellulose scaffold composite antibacterial unit and synergistically loading lysozyme.The bandage shows significant technical advantages in dealing with complex wound infection, especially gram-negative bacterial infection and drug-resistant bacterial challenge, and provides an efficient and safe solution for clinical wound management, and has important clinical application value and broad market prospect.
Owner:YUNGUANG TECH (SHENZHEN) CO LTD

Self-energized intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.
Owner:UNIV OF ELECTRONICS SCI & TECH OF CHINA

An anal fistula postoperative dressing and medicine placing device

ActiveCN224441905UDressing changeGuide tube
An anus fistula postoperative dressing and medicine putting device, including push tube, outer tube and front end guide tube, the inner cavity of outer tube is equipped with the channel of injection and push, one end of outer tube is rotating end, the other end is insertion end, the side of outer tube close to insertion end is equipped with outer thread, one end of front end guide tube is holding end, the other end is equipped with petal type opening, the inner thread of front end guide tube is equipped with the matching of outer thread, the middle part of push tube is equipped with cavity, one end of push tube is push end, the other end is piston end, the piston end of push tube is inserted from the side of rotating end of outer tube, and the piston end of push tube is sliding connection with outer tube, in initial state, the holding end of front end guide tube is screwed on outer tube, and the insertion end of outer tube is received in front end guide tube, the utility model discloses convenient operation, can control the depth of dressing, reduce the possibility of wound infection and anus fistula recurrence, shorten the wound healing period, reduce the patient's pain.
Owner:HUNAN YUNZISHAN HEALTH IND DEVELOPMENT CO LTD

A near-infrared light-responsive porous membrane and a preparation method and application thereof

ActiveCN119792613BAbsorbent padsBandagesReactive oxygen radicalsZno nanoparticles
This invention discloses a near-infrared light-responsive porous membrane, its preparation method, and its applications, relating to the field of dressing technology. The near-infrared light-responsive porous membrane is composed of polyurethane, PDA@ZnO nanoparticles, and the antibacterial agent QCS. Under near-infrared light excitation, this near-infrared light-responsive porous membrane can generate reactive oxygen free radicals and heat, and release biofunctional zinc ions. Addressing the clinical challenges of chronic wounds, such as their susceptibility to infection and slow healing, this invention provides a new approach to improving the clinical treatment of chronic wounds by using a PDA@ZnO / QCS / TPU porous membrane that achieves highly efficient and precise sterilization under the synergistic effect of specific wavelengths of light, thereby preventing wound infection and promoting wound healing.
Owner:ZHEJIANG UNIV

Surgical wound infection nursing management method based on image feature extraction

The application relates to the technical field of intelligent medical treatment, and discloses a surgical operation wound infection nursing management method based on image feature extraction. The method is based on dimension reduction reconstruction and gravity compensation fusion calculation of image extraction, and a single image acquisition action is split into three-dimensional form determination and rheological qualitative synergy gain. Through a core shape flow decoupling strategy, false positive noise introduced by light distortion and terrain undulation is effectively filtered out, and the specificity and robustness of pathological feature extraction under a complex observation domain are greatly improved. The visual research result is directly converted into a space approximation strategy under augmented reality guidance, a micro pneumatic pulse provides non-contact constant physical intervention, and the risk of secondary mechanical damage caused by traditional contact type exploration is avoided. A multiple information collaborative decision-making mode effectively breaks the shock dead loop problem in automatic medical inspection and intelligent micro-path planning.
Owner:XUZHOU MEDICAL UNIVERSITY

A minimally invasive postoperative adhesive plaster with wound closure function

ActiveCN224441391Ueffective closureclosed durationWound dressingAdhesive belt
This utility model relates to the field of minimally invasive postoperative wound dressing technology, specifically a minimally invasive postoperative wound dressing with wound closure function. It includes an adhesive layer, release paper installed on both sides of the bottom of the adhesive layer, low-sensitivity adhesive tape evenly installed on both sides of the top of the adhesive layer, and a sterilization layer embedded in the middle of the adhesive layer. The improved minimally invasive postoperative wound dressing adds a first elastic band and a second elastic band. When the wound dressing is applied to the wound surface, the first and second elastic bands can be pulled to traction the sides of the adhesive layer, thereby effectively closing the wound, reducing the risk of wound dehiscence, and promoting rapid wound healing. An absorbent layer made of highly absorbent resin is also added, allowing the absorbent layer to quickly absorb tissue fluid exudated from the wound during the healing process, helping to reduce the risk of wound infection and thus promoting wound healing.
Owner:YANGZHOU BESTCH MEDICAL TECH CO LTD

Taraxacum extract capable of neutralizing bacterial toxin and use thereof

The application discloses a dandelion extract capable of neutralizing bacterial toxins and application thereof. The dandelion extract is mainly prepared by the following method: fresh dandelion juice is squeezed, the juice is collected, the juice is centrifuged, the supernatant is collected, the supernatant is ultra-filtered, and components capable of passing through a filter membrane with a molecular weight cut-off of 100 kD and incapable of passing through a filter membrane with a molecular weight cut-off of 3 kD are collected, namely the dandelion extract. The dandelion extract obtained by the application is natural in composition, free of toxic side effects and high in biological activity. Experimental evidence shows that the dandelion extract can protect host cells from attack by directly and specifically combining with toxins, effectively neutralizes the toxicity of bacterial toxins, and has effective prevention and treatment effects on diseases such as systemic bacterial infection, wound infection and bacterial pneumonia. Therefore, the dandelion extract can be used as a new type of anti-microbial and anti-infection functional material and applied to the fields of functional food, health products, medicines or functional cosmetics.
Owner:NANJING UNIV OF TRADITIONAL CHINESE MEDICINE

Animal treatment observation device for animal husbandry and veterinary medicine and use method of animal treatment observation device

The invention relates to the technical field of animal husbandry treatment, and discloses an animal husbandry and veterinary animal treatment observation device and a use method thereof. According to the animal husbandry and veterinary animal treatment observation device and the using method thereof, through cooperation of the excrement leakage net plate and the inclined guide plate, animal excrement and urine rapidly fall down and are intensively discharged through the blow-off pipe, and it is avoided that pathogenic bacteria are accumulated and bred in an observation area, wound infection is caused, and the treatment effect is affected; meanwhile, the cleaning assembly achieves all-directional washing in the box through a high-pressure spraying head, the disinfection assembly atomizes a disinfectant and then evenly sprays the disinfectant to cover key parts such as the inner wall of the observation box and a feces leakage net plate, the cleaning and disinfection processes are integrated, cross infection of diagnosis and treatment gaps of different animals is effectively avoided, and an axial fan of the ventilation assembly accelerates air circulation; the temperature in the box can be adjusted in cooperation with an electric heating pipe, and the animals are prevented from catching cold; the temperature and humidity sensor monitors and feeds back data to ensure that the environment in the box is suitable, and good conditions are provided for animal recovery after treatment.
Owner:济南市公园发展服务中心

A series of controlled release nucleic acid nano probe composite hydrogel and its application in diagnosis and treatment of wound infection

This invention belongs to the field of medical technology, specifically relating to a tandem controlled-release nucleic acid nanoprobe composite hydrogel and its application in the diagnosis and treatment of wound infections. First, the invention modifies the surface of gold nanoparticles with nucleic acid sequences via Au-S bonds to prepare a DNA-gold nanoparticle probe (NAFP), achieving highly specific detection of sulfides, a wound infection marker. Then, using mesoporous silica as a carrier, an antibacterial drug is loaded, constructing mesoporous silica D@MSNs loaded with a double-stranded DNA molecule valve-type bactericide. Subsequently, the NAFP and D@MSNs are formulated into a gel to obtain a therapeutic dressing. This dressing can trigger conformational changes in nucleic acids through infection markers, achieving precise matching of drug release to the degree of infection, thereby enabling in-situ detection of bacteria. It also possesses highly efficient antibacterial activity, physical protection, and moisturizing functions. The dressing is easy to operate, has low clinical translation costs, and is suitable for the diagnosis and treatment of acute and chronic wound infections, showing broad application prospects.
Owner:SUN YAT SEN UNIV

Zwitterionic photosensitizer material, nano particle, and preparation method and application of zwitterionic photosensitizer material and nano particle

The invention belongs to the technical field of antibacterial materials, and particularly relates to a zwitterionic photosensitizer material, nanoparticles and a preparation method and application of the zwitterionic photosensitizer material and the nanoparticles. The structural formula of the zwitterionic photosensitizer material is shown in the specification, wherein x is any integer between 3 and 5; r1 and R2 groups are shown in the specification. The zwitterionic photosensitizer material based on sulfonation has excellent hydrophilicity and biological activity, can achieve an efficient sterilization effect at a low dosage, and has efficient curability on mouse living body wound infection, so that the zwitterionic photosensitizer material can be used for preparing a medicine for treating wound infection, and the problems that in the prior art, aggregation causes a fluorescence quenching effect, and the toxicity is poor are solved. And the problem of poor antibacterial treatment effect caused by reduction of ROS yield due to aggregation is solved.
Owner:GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA

Hydrogel wound dressing capable of rapidly stopping bleeding and preparation method thereof

The invention provides a hydrogel wound dressing capable of rapidly stopping bleeding. The hydrogel wound dressing is prepared from the following components in percentage by mass: 10 to 15 percent of polyethylene glycol, 5 to 10 percent of oxidized konjac glucomannan, 0.1 to 0.3 percent of cannabidiol, 0.5 to 2 percent of polydopamine nanoparticles, 8 to 12 percent of tannic acid modified carboxymethyl chitosan and the balance of corn starch. According to the hydrogel wound dressing, through cooperation of all the components, rapid hemostasis can be achieved, and the hydrogel wound dressing is especially suitable for domestic standing scenes, convenient to use and capable of rapidly stopping bleeding, reducing wound infection and easing pain.
Owner:GUANGDONG YUNZHAO MEDICAL TECH CO LTD

Nursing appliance combiner with skin cleaning function

PendingCN121360328AMedical applicatorsNursing careSkin clean
The invention discloses a nursing appliance combiner with a skin cleaning function, and belongs to the technical field of skin cleaning tools, the nursing appliance combiner comprises a front cover and a rear shell, a cleaning cover is clamped between the front cover and the rear shell, a supporting plate is clamped in the cleaning cover, a winding assembly is mounted between the front cover and the rear shell, and the winding assembly is connected with the cleaning cover. A cleaning belt used for cleaning wounds is wound in the winding assembly. When the cleaning device is used, the position of the adjusting sleeve is controlled, then the pressure column is repeatedly pressed, the cleaning belt can be subjected to medicine soaking treatment and can be rapidly replaced in the same cleaning process, a new cotton ball does not need to be replaced repeatedly, medicine does not need to be applied to the cotton ball repeatedly, and in this way, the cleaning efficiency can be remarkably improved; moreover, no fiber remains on the surface of the skin wound when the cleaning belt is used for cleaning the skin wound, so that the risk of wound infection is further reduced.
Owner:JIANGSU TAIZHOU PEOPLES HOSPITAL

A wound debridement device for a hematological tumor patient

ActiveCN116421337Breduce the risk of infectionspeed up healingHematological TumorWound debridement
The present application relates to the technical field of medical devices, in particular to a wound debridement device for blood tumor patients, comprising a handle vertically arranged, an injection part, an adsorption part and a mounting part for clamping medical cotton, the lower end of the handle is provided with a placing cavity, the mounting part is arranged in the placing cavity, the injection part comprises a first cylindrical cavity, a first button, a vertical slide and a first flow channel arranged in the handle, the mounting part comprises a fixing block arranged in the placing cavity and detachably connected with the handle, when the medical cotton is clamped on the handle by the fixing block, part of the medical cotton extends out of the lower end of the handle through the center hole of the fixing block, and the adsorption part comprises a second cylindrical cavity, a second button and an adsorption channel arranged vertically. The present application is simple and fast in operation when debriding the wound of the patient, greatly shortens the debridement time and reduces the labor intensity of medical staff, simultaneously reduces the time of exposing the wound of the patient to the outside, reduces the risk of wound infection and improves the wound healing speed.
Owner:THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV

An antibacterial silk fibroin gel dressing and a preparation method thereof

PendingCN122440887APolymer scienceSide chain
The application discloses an antibacterial silk fibroin gel dressing and a preparation method thereof, and belongs to the technical field of medical dressings. In order to solve the technical problems that the antibacterial components in the existing antibacterial silk fibroin gel dressing are prone to burst release, leading to initial cytotoxicity and mid-late invalidation, the covalent grafting density is low and the spatial accessibility is poor, and the chemical modification may interfere with the gel-forming performance of the gel, an in-situ functionalization strategy of chemical bonding is adopted, antibacterial active groups are directly introduced into silk fibroin macromolecular side chains through a covalent bond, and then the gel is formed by taking the groups as units, so that each silk fibroin molecular chain constituting the gel network itself becomes a carrier unit of the bactericidal function. The prepared antibacterial silk fibroin gel dressing is not only mild and controllable in the preparation process, and does not need to introduce toxic cross-linking agents or organic solvents, but also is stable and durable in antibacterial activity, high in biological safety, and can provide a novel functional dressing with practicability and advancement for clinical wound infection prevention and treatment.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES

Mass-spectrometry patch for wound infection detection and uses thereof

PendingCN122330251ALaser desorption ionization mass spectrometryMetabolite
This invention discloses a mass spectrometry patch for wound infection detection and its application, relating to the field of biomedical device technology. The mass spectrometry patch consists of a contact layer, a collection layer, and a protective layer from bottom to top. The contact layer is a polycarbonate mesh film, the collection layer is a polyvinylidene fluoride nanofiber membrane with high-density gold nanoparticles grown in situ on its surface, and the protective layer is a polyurethane film. This invention provides a wearable mass spectrometry patch integrating sampling and detection, achieving non-invasive sampling and direct mass spectrometry analysis. A single detection using laser desorption / ionization mass spectrometry can obtain a global metabolic fingerprint containing hundreds of metabolites, which simultaneously contains pathogen species-specific signals and host metabolic biomarker signals. By training an AI model to analyze the complex fingerprint, rapid pathogen identification and dynamic monitoring of host responses (such as lactic acid and glucose) can be completed simultaneously within 5 minutes, achieving decoupling of pathogen information from changes in host biomarkers.
Owner:SHANGHAI JIAOTONG UNIV

Burn wound negative pressure treatment and drug perfusion combined drainage device

The invention discloses a burn wound negative pressure treatment and medicine perfusion combined drainage device which comprises a shell, a negative pressure mechanism, an infusion mechanism, a drainage opening, a supporting mechanism, a pressing mechanism and an adsorption mechanism, a rotating ring is installed at the top of the shell, and a guide column is arranged on the inner wall of the rotating ring; the supporting mechanism is fixed in the shell and provided with a supporting channel, and the negative pressure mechanism penetrates through the supporting channel. A drainage opening is formed in the surface of the shell; the negative pressure mechanism comprises a connecting port, a negative pressure pipeline and a protruding block, and the connecting port is formed in the top of the negative pressure pipeline. Therefore, negative pressure treatment of the wound surface and medicine perfusion can be carried out synergistically, and wound surface infection can be controlled in time; a negative pressure system does not need to be disassembled and assembled in each time of perfusion, operation is greatly simplified, medical care burden is relieved, frequent operation on a wound surface is reduced, damage to new granulation tissue is avoided, pain of a patient is relieved, and the risk of secondary pollution caused by repeated exposure of the wound surface is reduced.
Owner:TAIHE HOSPITAL OF SHIYAN CITY (AFFILIATED HOSPITAL OF HUBEI UNIVERSITY OF MEDECINE)

Degradable traditional Chinese medicine microencapsulated liquid band-aid with pH response, early warning and controlled release and preparation method thereof

The invention discloses a degradable traditional Chinese medicine microencapsulated liquid band-aid with pH response early warning controlled release and a preparation method thereof, the traditional Chinese medicine microencapsulated liquid band-aid comprises micro-capsules and dispersion deionized water for dispersing the micro-capsules, and the mass ratio of the micro-capsules to the dispersion deionized water is (5-40): (50-400); the microcapsule is prepared from the following raw materials: chitosan, sodium alginate, Chinese mahonia-rhizoma bletillae mixed extract freeze-dried powder, blueberry anthocyanin, Tween 80, castor oil, litsea cubeba essential oil and calcium chloride in a mass ratio of (30-80): (30-80): (300-1500): (1-15): (50-400): (80-400): (50-400): (5-30), and deionized water is used as a solvent. The pH-responsive early-warning controlled-release degradable traditional Chinese medicine microencapsulated liquid band-aid disclosed by the invention has a visual early-warning function for wound infection, an intelligent targeted drug release function and double-effect functions of resisting infection and promoting healing, has the effects of expanding a use scene and improving user compliance, and has good biocompatibility and safety.
Owner:ZHEJIANG FORESTRY UNIVERSITY

Implantable insulin pump for supplying medicine through oral magnetic control capsule robot

The invention relates to an insulin pump for supplying medicine through a magnetic control capsule robot. The insulin pump comprises an implantable main body and the magnetic control capsule robot which can be taken orally and is filled with an insulin medicament, the implantable main body comprises a sealed shell, and a magnetic control module, a puncture module, a storage and transportation module and a power supply module which are integrated in the sealed shell. When the magnetic control capsule robot arrives near the right curve of the colon of the right inferior belly along the digestive tract, the magnetic control module of the implantable main body adsorbs and fixes the magnetic control capsule robot through magnetism; the puncture module punctures a shell of the magnetic control capsule robot through a puncture needle to establish a medicine channel; the storage and delivery module extracts insulin in the magnetic control capsule robot through negative pressure and stores the insulin, and then the insulin is pumped into the abdominal cavity of a patient through the piezoelectric micropump. According to the intraperitoneal infusion system, long-term wound opening caused by traditional in-vitro infusion is avoided for a type I diabetes patient needing to continuously supply insulin in a mode of orally taking the magnetic control capsule robot, non-invasive and accurate intraperitoneal infusion of insulin is achieved, and the wound infection risk of the type I diabetes patient can be remarkably reduced.
Owner:TIANJIN UNIV OF SCI & TECH

Antibacterial agent based on graphite-phase carbon nitride as well as preparation method and application of antibacterial agent

The invention belongs to the technical field of photocatalytic materials, and particularly relates to an antibacterial agent based on graphite-phase carbon nitride and a preparation method and application thereof.The surface of graphite-phase carbon nitride is wrapped with hyaluronic acid to obtain C3N4 / HA, and then an antibacterial agent is loaded to obtain the antibacterial agent. According to the antibacterial agent, hyaluronidase is consumed by modifying hyaluronic acid, the compactness of a drug-resistant bacterium biological membrane is reduced, and an antibacterial drug can be responsively released; the biological membrane is further destroyed by utilizing the special structure of graphite-phase carbon nitride, efficient sterilization is performed through a photocatalytic therapy and a chemical therapy in combination with an antibacterial drug under light mediation, new resistance of drug-resistant bacteria is effectively avoided, and the composite material can be used for treating wound infection caused by bacteria and has further popularization value.
Owner:HAINAN MEDICAL UNIV

Super-hydrophobic nanomaterials, methods of making and using the same

The application discloses super-hydrophobic nanometer material and a preparation method and application thereof. The super-hydrophobic nanometer material takes a hydrophobic polymer material as a main body, embeds hydrophobic modified two-dimensional inorganic nanometer material in the main body, and distributes or embeds the hydrophobic modified two-dimensional inorganic nanometer material on the surface of the main body. The super-hydrophobic nanometer material has a super-hydrophobic antibacterial adhesion and high-efficiency contact type sterilization dual function, has a self-cleaning characteristic, has high and persistent bacteriostatic efficiency, has a wide application prospect in wound repair and prevention of wound infection as a new type of dressing, and can be flexibly constructed into a multi-layer structure composite film dressing together with a hydrophilic nanometer fiber film to guarantee the biocompatibility of a dressing and a tissue contact surface and has high safety.
Owner:CHINA PHARM UNIV

Medical hydrogel dressing for wound repair and preparation method thereof

The invention discloses a medical hydrogel dressing for wound repair and a preparation method thereof, and relates to the technical field of hydrogel materials.The hydrogel dressing is prepared in a chemical cross-linking mode and a physical cross-linking mode, and the obtained hydrogel dressing can effectively reduce the wound infection risk and promote wound healing under the action of a natural antibacterial agent; the medical dressing has the advantages of being good in elasticity, ductility and adhesion, capable of being better attached to the complex wound surface shape, protecting the wound surface and absorbing exudate, capable of adapting to friction and displacement caused by body movement, capable of bearing a certain mechanical load without being broken, capable of prolonging the service life of the dressing and capable of improving the wound surface treatment efficiency.
Owner:ANHUI HUIKE BIO ENG TECH

Preparation and use of gramicidin and its antibacterial hydrogel formulations

The application provides a preparation of gramicidin and an antibacterial hydrogel preparation of the gramicidin, and discloses medical uses of the gramicidin, and provides a recombinant gramicidin, heterologous expression of the gramicidin is realized by constructing a Pichia pastoris recombinant strain, and the antibacterial activity of the gramicidin is retained, and the method has the advantages of simplicity and rapidness. Meanwhile, the hydrogel preparation of the gramicidin provided by the application shows good potential for treating wound infection of a diabetic mouse, and has the performance of rapid adhesion and hemostasis, lays a foundation for development of a new antibacterial drug, and provides a new direction for treatment of chronic inflammatory wounds and open bleeding.
Owner:JILIN UNIVERSITY

Multifunctional gradient structure artificial skin and preparation method and application thereof

The application discloses a multifunctional gradient structure artificial skin and a preparation method and application thereof, and belongs to the technical field of biomaterials and biomedical engineering. The upper layer of the application is a silica gel layer, which is used for simulating epidermis to keep a moist environment of a wound and simultaneously plays a barrier role; the intermediate layer is a degradable polymer / natural bioactive protein composite layer, which is used for enhancing mechanical properties; and the lower layer is a hydrogel layer, which is formed by cross-linking hyaluronic acid and carboxymethyl chitosan to form a Schiff base bond and then cross-linking collagen through catalysis. The composition of the hydrogel layer is a component of an extracellular matrix, and the three-dimensional network structure formed is beneficial to cell growth, can simulate a dermis layer to play a function of promoting tissue regeneration and remodeling, and finally the artificial skin with good mechanical strength, capable of preventing wound infection and promoting wound healing is obtained.
Owner:NANKAI UNIV

An orthopedic nursing dressing cart with lighting function

This utility model discloses an orthopedic nursing dressing change cart with lighting function, including a support mechanism. The support mechanism includes a base plate and columns. A caster wheel is fixedly installed at the bottom of the base plate, and a nursing tray for placing nursing instruments is provided at the top of the columns. A battery is installed inside the nursing tray, with a charging port protruding from the front of the battery. Inclined surfaces are provided on both the front and rear sides of the nursing tray, and lighting lamps are fixedly connected to both inclined surfaces. The battery is electrically connected to the lighting lamps. Positioning holes are provided at the top of the four columns. Inserts matching the positioning holes are fixedly connected to the four corners of the bottom surface of the nursing tray, with the lower ends of the inserts engaging in the positioning holes to achieve a detachable connection between the nursing tray and the columns. This utility model effectively avoids problems such as incomplete wound cleaning and dressing change errors caused by insufficient light, greatly improving the accuracy of dressing change operations, reducing the risk of wound infection for patients, and promoting wound healing.
Owner:THE FOURTH AFFILIATED HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE

High-absorbability medical absorbent cotton roll and preparation method thereof

The invention discloses a high-absorbability medical absorbent cotton roll and a preparation method thereof, and belongs to the technical field of medical materials. The preparation method comprises the following steps: preparing sulfur-doped pH response carbon dots by taking forestry waste lignin as a raw material, and compounding a natural plant antibacterial extract and a temperature-sensitive copolymer to form a modified solution; degreasing cotton is activated through low-temperature plasma to improve the surface activity, modified components and cotton fibers are firmly combined through vacuum impregnation crosslinking, and then a finished product is obtained through gradient compaction forming. The medical absorbent cotton roll has pH-temperature double response, antibacterial and anti-inflammatory and high water absorption synergistic performance, the liquid absorption capacity far exceeds the industrial standard, water retention is lasting, the medical absorbent cotton roll can sensitively respond to the wound infection environment and play an efficient and lasting antibacterial role, the medical absorbent cotton roll is suitable for postoperative wound nursing scenes and wound nursing scenes with high infection risk, the preparation process is green and environmentally friendly, and the medical absorbent cotton roll has good application prospects. And the method has good industrialization feasibility.
Owner:JIANGSU LIKANG GROUP CORP