459 results about "Wound infection" patented technology

The invention relates to an infectious bacterium detection method and system based on double effects of a reflection spectrum and autofluorescence, and belongs to the field of biomedical detection. The method comprises the following steps: acquiring hyperspectral images of different samples under different light sources; performing data preprocessing on the collected sample hyperspectral image, realizing pixel-level alignment of the dual-effect image based on feature matching and image registration, and constructing a data set; the method comprises the following steps: constructing a wound infection bacterium detection model based on double effects of a reflection spectrum and autofluorescence, and comprising a double-branch feature extraction module which comprises a reflection branch and a fluorescence branch which are respectively used for extracting reflection hyperspectral image features and fluorescence hyperspectral image features; the redundant feature screening module screens the features extracted by the reflection branch and the fluorescence branch through a channel attention mechanism; and the feature fusion module adopts a cross-branch cross attention mechanism to fuse the features of the double branches. According to the method, learning is carried out from two physicochemical characteristics, and the effectiveness and adaptability of the technology are improved.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a hydrogel wound dressing for promoting healing of infectious wounds. The hydrogel wound dressing is prepared from the following raw materials: oxidized methacrylic acid hyaluronic acid, waterborne polyurethane, polylysine, cannabidiol, neomycin sulfate and 2-roots alcohol. The invention also provides a preparation method of the hydrogel wound dressing and application of the hydrogel wound dressing in preparation of products for repairing infectious wounds. The wound dressing provided by the invention has a microporous structure, good biocompatibility and biodegradability, and can be used for stopping bleeding, reducing wound infection and promoting cell proliferation and wound healing.

The invention relates to the technical field of health risk assessment, in particular to an intelligent early warning system for postoperative infection risk of orthopedic trauma. The system comprises a data acquisition module for acquiring physiological feature data and biomarker data; the key monitoring and screening module screens key monitoring patients according to the continuous abnormal representation growth degree of the initial physiological signs; the infection risk assessment module obtains a marker level index by using the initial deviation level and the growth amplitude of the biomarker, and obtains a wound infection risk coefficient in combination with the prediction condition of historical biomarker data; and the early warning report generation module is used for dividing patient early warning levels according to the physiological parameter abnormality and the wound infection risk coefficient to generate a risk report. According to the method, the evaluation accuracy of postoperative infection is improved through the physiological sign abnormity continuity and the biomarker sudden increase and prediction trend, the subsequent early warning level and risk report generation are more reliable, and a more personalized and accurate treatment scheme can be provided for a patient.

The invention provides a fiber dressing for promoting wound healing and a preparation method and application thereof, and belongs to the technical field of biological materials. The shell of the fiber dressing contains the first medicine for promoting polarization of macrophages, and the first medicine can promote polarization of macrophages at normal and diabetic wound surfaces from M1 type to M2 type; a shell substrate is a mixture of hydrophilic and hydrophobic polymers, so that painless adhesion and stripping of a wound surface can be realized by absorbing seepage and spraying non-irritant normal saline on the wound surface, and secondary injury of the wound surface is reduced; an inner core contains a second medicine and a third medicine which are used for inducing death of M1 type macrophages, so that wound inflammatory response can be reduced, wound bacteria can be killed, wound infection degree can be reduced, and wound healing can be accelerated; the core matrix is a mixture of hydrophilic and hydrophobic polymers with good biocompatibility, can provide mechanical support for the fiber dressing, and provides a slow release effect for the two substances in the core. By controlling the composition of the inner core and the shell, the healing of normal wounds and diabetic wounds can be effectively promoted.

The invention discloses an ultrashort-sequence antibacterial peptide rich in lysine and tryptophan, an antibacterial peptide hydrogel and application of the ultrashort-sequence antibacterial peptide and the antibacterial peptide hydrogel. The preparation method comprises the following steps: combining lysine and tryptophan to obtain polypeptide containing five or six amino acids; then amidation is carried out on the C terminal of the polypeptide, fatty acid chain modification is carried out on the N terminal and side chain amino groups, the ultra-short sequence antibacterial peptide rich in lysine and tryptophan is obtained, and the antibacterial peptide has broad-spectrum antibacterial activity for resisting gram-positive and gram-negative bacteria. An antibacterial peptide micelle self-assembly experiment shows that C12-2KW can be self-assembled into stable hydrogel in a 7.17 mu M PBS (Phosphate Buffer Solution), the hydrogel internally has a compact net-shaped structure, can completely cover the peritoneal injury surface and physically isolate the peritoneal injury surface from surrounding tissues, and has a good effect on treating wound infection caused by MRSA (Methicillin-Resistant Staphylococcus Aureus); meanwhile, the compound has the effect of resisting intestinal wall and abdominal wall adhesion after an operation, is low in toxicity, has a very good application prospect in the aspect of preparing clinical antibacterial drugs, and is expected to become a candidate drug of a novel antibiotic.

The invention relates to the technical field of medical rehabilitation devices, and provides a neck rehabilitation device after a neck operation, the neck rehabilitation device comprises a lower jaw supporting disc and a shoulder supporting disc, limiting discs are fixedly mounted on the sides, close to each other, of the lower jaw supporting disc and the shoulder supporting disc, and limiting insertion holes are uniformly formed in the sides, close to each other, of the limiting discs; adjusting and supporting mechanisms, photon treatment mechanisms and massage mechanisms are alternately arranged between the upper limiting disc and the lower limiting disc, the upper ends and the lower ends of the photon treatment mechanisms and the massage mechanisms are inserted into the limiting insertion holes, and the upper ends and the lower ends of the adjusting and supporting mechanisms are fixedly installed on the sides, close to each other, of the limiting discs. The neck of a patient can be comfortably supported and braked by adjusting the supporting mechanism, meanwhile, the vertical height can be adjusted to adapt to patients with different neck lengths, and the photon treatment function, namely red and blue light irradiation treatment, prevention of neck wound infection and promotion of early healing of a wound, of the neck of the patient is achieved through the photon treatment mechanism.

The invention discloses a gastric cancer postoperative chemotherapy dynamic intervention method and system based on time point matching, and relates to the technical field of postoperative intervention. Health state data of wearable medical equipment of a gastric cancer postoperative patient is collected; preliminarily dividing the stomach cancer postoperative chemotherapy cycle into a plurality of key physiological time points based on the symptom inflection points, and respectively matching an intervention core problem and a corresponding stomach cancer postoperative chemotherapy intervention scheme for the plurality of key physiological time points; and the postoperative intervention platform analyzes the time period health state data collected by the wearable medical equipment at set time intervals, analyzes the health state data to automatically identify gastric cancer postoperative symptom inflection points, and dynamically matches key physiological time points based on symptom inflection point results. The stomach cancer postoperative treatment disruption rate is reduced, the crisis inflection point recognition accuracy is greatly improved, and the bone marrow suppression early diagnosis rate is greatly improved; the early diagnosis rate of postoperative wound infection of gastric cancer is improved, unnecessary intervention is reduced, and crisis event treatment is accelerated.

The invention belongs to the field of hydrogel application, and discloses an MOF-based wound dressing and a preparation method thereof, and the MOF-based wound dressing is a composite material prepared by reaction of carrier hydrogel GHA (GelMA / HAMA) and Cu / ZIF-8-coated Cur antibacterial particles. The GHA hydrogel is formed by the cross-linking of methacrylated gelatin (GelMA) and methacrylated hyaluronic acid (HAMA). The invention further discloses a preparation method of the GHA hydrogel. The problems of wound infection, slow healing speed and the like caused by lack of controllable hygroscopicity, poor antibacterial property and the like of the existing wound dressing can be solved, and the wound dressing has biocompatibility, pH responsiveness and antibacterial property.

The invention discloses a medicine for treating bedsore and application thereof.The medicine is prepared from parthenocissus tricuspidata, clove, radix aucklandiae and borneol, the parthenocissus tricuspidata serves as a monarch drug and has the effects of promoting blood circulation, removing toxins, removing blood stasis, dredging collaterals, improving local blood circulation of bedsore, promoting inflammation fading, dissolving sore and ulcer toxins and repairing damaged tissue; the clove is used as a ministerial drug to expel pus and engender tissue, inhibit wound infection and promote healing of ulcerated wounds; the radix aucklandiae is used as an adjuvant drug for promoting qi circulation, promoting blood circulation and promoting qi hyperactivity and blood circulation, and the radix aucklandiae is used as a monarch drug for removing stasis and dredging collaterals to nourish tendons and meat; borneol is used as an assistant drug, is used for resisting bacteria, relieving pain and promoting healing of non-healing after bedsore ulceration, and also can be used as a meridian guiding drug to enhance the seepage force of the drug so as to promote external transdermal absorption of the drug. Through simple composition and reasonable compatibility of the medicines, local qi and blood stasis of bedsores can be improved and wound healing can be promoted through the multi-target effect by activating blood and detoxifying, expelling pus and promoting tissue regeneration and inhibiting bacteria to control infection, so that the bedsores can be effectively treated.

The invention provides a nursing film device and system for hepatobiliary operation wound healing, and the nursing film device and system comprises a film-shaped carrier which is composed of a substrate layer and an adhesion layer, the substrate layer is adhered to the skin wound of a patient, and a plurality of hole grooves are formed in the substrate layer in a hollowed-out manner; the adhesion layer is adhered to the upper part of the substrate layer; the sensor assembly is composed of an infection indication sensor, an oxygenation sensor, a humidity indication sensor, a blood flow sensor and a wound healing progress sensor; monitoring the wound infection degree, oxygenation degree, humidity, blood flow degree and wound healing progress; the plurality of balloons are attached in the adhesive layer, and growth factors, analgesic and antibiotics are respectively wrapped in the balloons; wherein an electrode layer is arranged above the adhesion layer; the electrode layer is connected with a control assembly, and after the control assembly receives sensing information of the sensor assembly, the control assembly controls all the balloons to be released, and wound repairing is achieved.

The invention discloses a hydrogel adhesive based on gelatin and a clay material and a preparation method of the hydrogel adhesive. The hydrogel adhesive at least comprises the following preparation raw materials: modified gelatin, a modified clay material and a thiolated cross-linking agent. The hydrogel adhesive prepared by the invention has an excellent tissue adhesion effect in a moist environment, can form gel within 30-60s, has flexibly adjustable adhesion performance, and can meet the application of various surgical scenes. The fibrin glue has the blood coagulation promoting effect, the hemostasis effect is better than that of traditional fibrin glue, the antibacterial effect is achieved, the risk of wound infection is reduced, meanwhile, good elasticity and toughness are achieved, the matching degree with tissue mechanical properties is high, and the fibrin glue cannot lose efficacy during cyclic compression. The biological compatibility is good, the anti-inflammatory and anti-oxidation effects are achieved, and wound healing and regeneration can be accelerated.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The invention relates to the technical field of medical detection and spectral analysis, and discloses a spectrum detection method for microorganisms on a wound surface based on knowledge data dual-drive envelope fusion. The method comprises the following steps: firstly, acquiring a multi-band near-infrared spectrum signal of a wound surface through a fiber optic spectrometer, and carrying out normalization and smooth filtering pretreatment; analyzing optical characteristic parameters based on a diffuse reflection theory model, constructing a knowledge-driven characteristic sample space, extracting spectral high-order characteristics by using a one-dimensional deep convolutional neural network, and constructing a data-driven characteristic sample space; then generating a grain envelope sample through a double-flow feature fusion mechanism; and finally, constructing a lightweight dual-task classification model based on the particle envelope sample, and realizing rapid detection of fungal infection of the wound surface and identification of seven common bacteria. According to the method, the interpretability, the recognition precision and the robustness of characteristic pathology are considered, and an efficient and reliable technical scheme is provided for early clinical diagnosis of wound infection.

The invention relates to the technical field of biological medicine, in particular to application of a stable silicic acid aqueous solution in preparation of a product for treating war wound infection, and the mass concentration of the stable silicic acid aqueous solution is 0.5%-2%. The product taking the stable silicic acid aqueous solution as the active ingredient can be used for treating war wound infection or cryptococcus gattii infection, can resist cryptococcus gattii infection at the mass concentration of 0.5-2%, and has the effect of resisting war wound infection, and meanwhile, the stable silicic acid aqueous solution is low in raw material cost, environment-friendly, safe and suitable for industrial production. The compound can be used as a substitute medicine of a traditional medicine miconazole with a good curative effect.

The invention discloses a hydrogel wound dressing and a preparation method thereof, and belongs to the technical field of medical wound dressing preparation. The preparation method comprises the following steps: S1, preparing chitosan-silver nanoparticles CS-Ag; s2, preparing aminated chitosan-silver nano particles (CS-Ag-NH2), and preparing the chitosan-silver nano particles, s3, a hydrogel wound dressing CNF / CS-Ag-NH2 is prepared; the CNF is a carboxylated cellulose nanofiber. According to the prepared CNF / CS-Ag-NH2 hydrogel wound dressing, through the synergistic effect of the carboxylated cellulose nanofibers and the aminated chitosan-silver nanoparticles, the organic combination of the antibacterial property and the healing promoting property is realized; the hydrogel wound dressing not only can effectively control wound infection, but also can promote wound healing, and has a wide application prospect.

The invention discloses a wound infection assessment method and system based on a pH monitoring model, and relates to the technical field of wound infection assessment, a pH data set and a wound feature set are extracted based on historical wound samples, data processing is performed on the pH data set to obtain a pH feature parameter set, the pH monitoring model is constructed according to the pH feature parameter set, and the wound infection assessment method and system based on the pH monitoring model are obtained. Carrying out model training on the pH monitoring model through the wound feature set; a to-be-detected wound sample is obtained, wound infection evaluation of the to-be-detected wound sample is carried out through the pH monitoring model after model training is completed, and then an infection preliminary indication of a wound corresponding to the current to-be-detected wound sample is obtained; the wounds are divided into different infection grades according to the initial infection indications, infection trend follow-up judgment is carried out on the wounds of the different infection grades in a set monitoring period, and then the infection evolution condition of the wounds is obtained.

The invention discloses a biomedical polymer-based wound infection indicating dressing material as well as a preparation method and application thereof, and the dressing material is obtained by modifying a pH responsive dye, performing graft polymerization on the modified pH responsive dye, a cross-linking agent and hydrophilic monomer free radicals to form a hydrogel coating, and then wrapping the hydrogel coating on a biomedical polymer material. The material has a pH responsive infection indication function, can amplify a wound infection condition which is not easy to detect into a color change which is intuitive and distinguishable by naked eyes, can meet the requirement of monitoring the skin wound infection condition in actual clinical application, is beneficial to early detection of wound infection, and has a wide application prospect. And the preparation method can maintain the original texture of the biomedical polymer material to the greatest extent and reduce the risk of dye exudation, and the preparation process is conventional and easy to operate and has wide engineering prospects.

A preparation method of antibacterial hydrogel with enhanced antioxidant activity and NIR / pH double responsiveness comprises the following steps: firstly, preparing hollow copper sulfide nanoparticles, then dispersing the hollow copper sulfide nanoparticles into a chitosan solution to prepare the chitosan solution containing the hollow copper sulfide nanoparticles, and then adding the hollow copper sulfide nanoparticles into the chitosan solution to prepare the antibacterial hydrogel with enhanced antioxidant activity and NIR / pH double responsiveness. And sequentially adding a cross-linking agent epigallocatechin gallate (EGCG) solution and a 3-formyl phenylboronic acid solution (3-FPBA), and carrying out cross-linking, so as to obtain the antibacterial hydrogel with enhanced antioxidant activity and NIR / pH double responsiveness. The hydrogel is used for wound dressings in biomedical engineering materials. The preparation method is simple, the preparation process is green and safe, higher solid-like performance is shown, meanwhile, excellent injectability is kept, and great advantages can be achieved in the bacterial wound infection healing process.

The invention provides an implantable piezoelectric device and a manufacturing method thereof. The implantable piezoelectric device comprises a device frame, an upper electrode layer, a lower electrode layer and a piezoelectric sensitive layer. According to the implantable piezoelectric device provided by the invention, the deformation degree of the piezoelectric sensitive material under load force is enhanced by using a dot matrix process, the piezoelectric output performance of the device is improved, and the sensitivity of the device is enhanced; in addition, the W-shaped structural design of the device frame is beneficial to alignment and fixation of layers in the piezoelectric device, and the grooves are formed in the edges of the device frame, so that adhesive filling is facilitated, and the sealing performance of the device is enhanced. The size and thickness of the whole device are reduced under the reasonable structural design, so that the implanted wound area is reduced, the wound infection risk is reduced, and the service life of the device is prolonged. And the device frame adopts an integrated manufacturing process, and large-scale industrialization can be realized. Each part of the implantable piezoelectric device is detachable and supports independent replacement, and the implantable piezoelectric device is high in repeatability and convenient to use.

The invention discloses a traditional Chinese medicine hydrogel composition for preventing and treating anorectal postoperative wound infection as well as a preparation method and application of the traditional Chinese medicine hydrogel composition. Based on traditional Chinese medicine classical ointment powder and in combination with clinical experience, chemical cutting optimization is performed to form a traditional Chinese medicine compound preparation, and the traditional Chinese medicine compound preparation is wrapped by taking a high polymer material as a skeleton and taking glycerol as a wrapping agent; and a stable temperature-sensitive in-situ hydrogel administration system is formed, so that the combination of the traditional Chinese medicine preparation and the hydrogel is realized, and the problems of the traditional ointment are effectively solved. The traditional Chinese medicine hydrogel composition directly acts on a wound surface, is good in adhesiveness and histocompatibility, and can prolong the residence time of a medicine at a medication part and improve the bioavailability; the active ingredients of the traditional Chinese medicine compound preparation can prevent the formation of bacterial biofilm on the wound surface after anorectal operation and inhibit wound surface infection; the hydrogel dosage form enables the hydrogel to form a moist protective film on a postoperative wound surface and form a microenvironment beneficial to wound surface healing, so that healing is accelerated, rehabilitation is promoted, the pain of a patient is effectively relieved, and the hydrogel has important medical value.

The special ointment for burns and scalds comprises the following substances in parts by weight: 20-30 parts of dragon's blood; 40-60 parts of rheum officinale; 4-6 parts of borneol; 80 to 120 parts of gypsum; and 120 to 180 parts of a greasy matrix. Compared with the prior art, the prepared special ointment for burns and scalds has the advantages of quick effect, quick wound healing, no need of binding, no need of hospitalization treatment for light and moderate burns and scalds which do not endanger life, simple operation, economy and applicability. And moreover, wound infection can be greatly reduced by using the product, and good news can be brought to burn and scald patients.

The invention discloses a method and system for predicting early infection of a child burn wound, and the method comprises the steps: S1, obtaining the information of the child burn wound, and monitoring the local temperature, pH value, specific inflammatory marker level and original data of pathogen nucleic acid of the burn wound; s2, generating a trend change comprehensive model by using a time sequence analysis algorithm; s3, key features are extracted through an adaptive feature selection technology trend change comprehensive model, and data dimensions are reduced; s4, adopting a transfer learning method to perform pre-training in the burn case as a risk assessment model, and utilizing the risk assessment model to generate an infection risk score; and S5, setting a risk threshold value, and when the infection risk score exceeds a preset threshold value, performing early warning, marking child wound infection, generating a detailed infection report, and performing targeted treatment. According to the method, the problem that a high-performance prediction model is difficult to directly construct due to relatively small child medical data volume and complexity is solved, and the ability of early infection recognition of children is improved.

The invention relates to the field of preparation of conductive hydrogel, in particular to a preparation method and application of a visual multifunctional ionic conductive hydrogel sensor. Polyvinyl alcohol and N-isopropylacrylamide are used as a double-network framework, acrylic acid and lithium chloride are used as functional fillers, and a chemical / physical cross-linking effect is formed through mechanical stirring, so that the visual multifunctional ionic conductive hydrogel sensor is constructed. The hydrogel has dual responsiveness to strain / temperature, when the hydrogel is used as a wearable strain sensor, the overall signal response is kept stable after the hydrogel is subjected to multiple cyclic stretching cycles, and the hydrogel can be used for detecting large-amplitude and fine movement of a human body and can be used as a wearable temperature sensor. Based on the color development characteristic of hydrogel along with temperature change, the hydrogel can be used as a visual color-changing sticker to give early warning for patients suffering from fever, inflammation and wound infection, and a traditional temperature measurement method is improved to a great extent.

The invention provides a Janus fabric loaded with composite antibacterial nanoparticles and a preparation method, and relates to the technical field. According to the Janus fabric loaded with the composite antibacterial nanoparticles, one side of the fabric is a hydrophobic antibacterial surface, and the other side of the fabric is a hydrophilic healing promoting surface; composite antibacterial nanoparticles containing chlorogenic acid and metal ions are loaded on fibers on two sides of the fabric. The preparation method comprises the following steps: firstly, preparing antibacterial nanoparticles coupled with chlorogenic acid and metal ions, then adsorbing the antibacterial nanoparticles on the fiber surface of the fabric by virtue of an impregnation process, and finally, carrying out hydrophobic antifouling antibacterial modification on one side of the fabric by virtue of a single-side spraying process, so as to finally prepare the Janus antibacterial fabric, which is a simple and efficient preparation method of the antibacterial fabric. The method has a huge application prospect in the fields of wound infection prevention and healing promotion.

The invention discloses temperature-sensitive antibacterial hydrogel based on ultra-small-particle-size copper nanoparticles and a preparation method of the temperature-sensitive antibacterial hydrogel, and relates to the technical field of biomedical materials. The preparation method of the temperature-sensitive antibacterial hydrogel comprises the step of uniformly mixing the gel matrix, the stabilizer, the pH buffer solution and the ultra-small-particle-size copper nanoparticles to prepare the temperature-sensitive antibacterial hydrogel. The preparation method of the copper nanoparticles with the ultra-small particle size comprises the following steps that lactoferrin is dissolved in water, copper sulfate pentahydrate is added, an alkali solution is added to adjust the pH of the solution to be 8-14, then a reducing agent is added for a reaction, dialysis and drying treatment are conducted, and the copper nanoparticles with the ultra-small particle size are obtained. The hydrogel has good injectability, can release the copper nanoparticles under specific conditions and rapidly sterilize, in addition, the hydrogel is convenient to synthesize and simple to operate, has good biocompatibility, shows relatively low cytotoxicity to cells, and has relatively great application potential in the process of treating skin wound infection.

The invention discloses guar gum hydrogel with biological activity and a preparation method and application thereof, and the preparation method comprises the following steps: adding tannic acid and a soluble ferric iron source into a guar gum solution, then adding a cross-linking agent, and carrying out a cross-linking reaction to obtain the guar gum hydrogel with biological activity. The hydrogel disclosed by the invention has good mechanical properties and self-repairing performance, can effectively prevent the hydrogel from being damaged and torn, avoids wound infection, is beneficial to providing a good repairing environment for wounds, and is beneficial to improving the healing effect of the wounds by integrating lysine with biological activity into guar gum hydrogel. The biocompatibility of the guar gum hydrogel is improved, and the capacity of promoting the healing of infected wounds is improved.

The utility model relates to a self-adhesive disposable pressurizing application which comprises an elastic pressurizing body, the elastic pressurizing body is arranged between an inner-layer dressing and an outer-layer dressing, the elastic pressurizing body comprises a plane pressurizing part and a vertical face pressurizing part, the vertical face pressurizing part protrudes out of the surface of the plane pressurizing part, and the outer-layer dressing is arranged on the surface of the vertical face pressurizing part. The surface, provided with the vertical surface pressure applying part, of the plane pressure applying part is bonded with the outer-layer dressing, and the opposite surface of the plane pressure applying part is bonded with the inner-layer dressing; the inner-layer dressing and the outer-layer dressing are correspondingly provided with a plurality of fixing bands extending outwards, the fixing bands are symmetrically arranged, the fixing bands can be pasted more firmly, meanwhile, the elastic pressurizing body exerts pressure on a wound in a balanced mode, the wound is prevented from being dragged, stable healing of the wound is facilitated, the structure is simple, use is convenient, seepage at the wound can be obviously reduced, and the wound healing effect is improved. And wound infection is prevented, the number of times of repeated dressing change is reduced, the labor intensity of nursing personnel is reduced, meanwhile, wound infection is prevented, medical consumables are saved, and the sterility and safety of the product are guaranteed through ethylene oxide disinfection and disposable use.

A composition comprising Cutibacterium acnes (also known as Propionibacterium acnes or Corynebacterium parvum), C. acnes culture supernatant and / or a bioactive extract or metabolite obtainable from C.

The utility model relates to an artificial ear, which comprises a first part and a second part, and is characterized in that the first part comprises a first body and a first connecting part arranged on the first body, and the first body is provided with the outline of an ear; the second part is used for being pasted on the wearing part of the patient, the second part comprises a second body and a second connecting part arranged on the second body, and the second connecting part can be matched with the first connecting part to achieve connection of the first part and the second part. In the application, the first part and the second part are detachably connected, so that after the second part is adhered to the wearing part of the patient, the patient can conveniently wear or take off the first part, an operation is not needed, and the risk of wound infection cannot be brought to the patient.