207 results about "Wound infection" patented technology

The invention relates to an infectious bacterium detection method and system based on double effects of a reflection spectrum and autofluorescence, and belongs to the field of biomedical detection. The method comprises the following steps: acquiring hyperspectral images of different samples under different light sources; performing data preprocessing on the collected sample hyperspectral image, realizing pixel-level alignment of the dual-effect image based on feature matching and image registration, and constructing a data set; the method comprises the following steps: constructing a wound infection bacterium detection model based on double effects of a reflection spectrum and autofluorescence, and comprising a double-branch feature extraction module which comprises a reflection branch and a fluorescence branch which are respectively used for extracting reflection hyperspectral image features and fluorescence hyperspectral image features; the redundant feature screening module screens the features extracted by the reflection branch and the fluorescence branch through a channel attention mechanism; and the feature fusion module adopts a cross-branch cross attention mechanism to fuse the features of the double branches. According to the method, learning is carried out from two physicochemical characteristics, and the effectiveness and adaptability of the technology are improved.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The application discloses a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. A hydrogel network formed by dynamic covalent crosslinking between carboxymethyl chitosan and oxidized sodium alginate is utilized; further, a natural antioxidant, gallic acid, with a catechol structure is introduced to enhance the tightness of the hydrogel network combination and endow the hydrogel with certain adhesion and antioxidant properties; finally, a mussel adhesive fluid containing catechol and iron is imitated to have strong tissue adhesion behavior under alkaline conditions, which is suitable for dynamic wound treatment, so as to prepare a mussel-inspired multifunctional double-network crosslinked hydrogel wound dressing. In addition, catechol-Fe 3+ Metal coordination also shows strong antibacterial effect, and under the irradiation of near-infrared light, light energy can be converted into heat energy for preventing and treating wound infection, shortening wound closure time and preventing scar formation.

The invention relates to the technical field of medical detection and spectral analysis, and discloses a spectrum detection method for microorganisms on a wound surface based on knowledge data dual-drive envelope fusion. The method comprises the following steps: firstly, acquiring a multi-band near-infrared spectrum signal of a wound surface through a fiber optic spectrometer, and carrying out normalization and smooth filtering pretreatment; analyzing optical characteristic parameters based on a diffuse reflection theory model, constructing a knowledge-driven characteristic sample space, extracting spectral high-order characteristics by using a one-dimensional deep convolutional neural network, and constructing a data-driven characteristic sample space; then generating a grain envelope sample through a double-flow feature fusion mechanism; and finally, constructing a lightweight dual-task classification model based on the particle envelope sample, and realizing rapid detection of fungal infection of the wound surface and identification of seven common bacteria. According to the method, the interpretability, the recognition precision and the robustness of characteristic pathology are considered, and an efficient and reliable technical scheme is provided for early clinical diagnosis of wound infection.

The invention discloses a high-moisture-permeability hydrogel nursing patch and a preparation method thereof, and belongs to the technical field of medical supplies. Sodium alginate and gelatin are scientifically compounded to serve as a gel skeleton, functional components such as the aloe extract, the humectant and the penetration enhancer are supplemented, a stable three-dimensional network structure is constructed, the synergistic effect of multiple effects of moisturizing, resisting bacteria, promoting absorption of active ingredients and the like is achieved, and the synergistic improvement of high moisture permeability, antibacterial property and mechanical property of the product is achieved; the prepared nursing patch can quickly and largely absorb exudate at a wound, keep the wound clean and dry, reduce the risk of wound infection by absorbing the exudate, promote wound healing, effectively relieve skin surface wounds and scratches, and avoid skin infection and ulceration caused by the wounds.

The present application relates to a kind of carboxymethylated gellan gum composite hydrogel that can promote the preparation method of infectious skin wound healing, the present application will be a certain concentration of carboxymethylated gellan gum with the solution of active ion (Ca 2+ 、Cu 2+ 、Zn 2+ ) of proper proportion, using ion crosslinking method to prepare carboxymethylated gellan gum hydrogel.The prepared hydrogel has fast gelation, good injectability, self-healing, tissue adhesion performance and excellent bacteriostatic effect, and can effectively promote the healing of infected wound, has potential application prospect in the treatment of wound infection.

This invention discloses a time-division multiplexed dual-mode monitoring sensor for blood glucose and implanted wound infection, and its monitoring method. The sensor includes an electrically connected sensing unit and a detection unit. The sensing unit includes a three-electrode system of sensing electrodes, and the detection unit includes a chronoamperometry circuit for blood glucose measurement, an open-circuit voltage method circuit for wound pH measurement, a switching circuit, and a control module. The control module regulates the switching circuit, enabling the sensor to alternately perform blood glucose and implanted wound pH measurements in a time-division multiplexed manner. Based on the pH measurement data, the blood glucose measurement results can be dynamically calibrated, and an alarm is triggered when the wound infection level measured by the pH measurement data exceeds a preset threshold. This invention optimizes the combination relationship of the three-electrode system and the timing control of the detection modes, achieving simultaneous detection of two indicators without adding additional electrodes. This not only improves detection accuracy and wearing comfort but also simplifies the device structure and reduces costs, showing great application potential.

The present application relates to the technical field of medical materials, and discloses a medical sterilization fiber dressing and a preparation process thereof. The dressing comprises a functional substrate and an electrochemically active component. The functional substrate comprises cyclodextrin grafted chitosan and sodium alginate, and the electrochemically active component comprises zinc powder and copper powder. The dressing utilizes the zinc powder and copper powder to form a micro-battery in an electrolyte environment, releases zinc ions and generates a micro-electric field to kill bacteria. At the same time, the cavity structure of the cyclodextrin grafted chitosan specifically recognizes and includes wound infection markers, and then regulates the reaction rate of the micro-battery, so as to realize the on-demand release of sterilization activity. The preparation process comprises the following steps: mixing the components to prepare a spinning solution, forming in a calcium chloride solution through wet spinning, and then stretching and drying to obtain the fiber dressing. The dressing can respond to the wound infection state, realize on-demand sterilization, and has good biocompatibility.

The present application relates to the technical field of biological materials, in particular to a light-responsive drug gel carrier and a preparation method thereof, in order to improve the controlled release function of the hydrogel material, the methyl methacrylate nitrobenzene compound containing nitrobenzene structure, hydantoin structure and propylene structure is prepared first, under the action of a photoinitiator, the double bond is crosslinked with methyl methacrylate and ethylene glycol methacrylate to form a hydrophilic gel network, so that the drug gel carrier is obtained; wherein the nitrobenzene structure has photosensitivity, and the crosslinking structure will be broken under ultraviolet irradiation, thereby reducing the stability of the gel material, destroying the rearrangement of the gel micelle structure, and realizing the release of the loaded drug; and the hydantoin structure introduced in the methyl methacrylate nitrobenzene compound also has good antibacterial performance, which can effectively avoid wound infection and improve wound recovery.

The invention provides a rhizoma bletillae composition as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine preparations. The core effective component of rhizoma bletillae is rhizoma bletillae polysaccharide, the rhizoma bletillae polysaccharide has the effects of film forming, hemostasis, targeted wound repair promotion and infection prevention, tea polyphenol and rhizoma bletillae are compounded for use, the tea polyphenol and rhizoma bletillae synergistically resist inflammation, the expression quantity of proinflammatory factors IL-1beta, TNF-alpha and IL-6 is reduced by inhibiting NF-kappa B and MAPK signal channels, the inflammatory cascade reaction is remarkably blocked, and the anti-inflammatory effect is achieved. Red, swollen and pain caused by inflammation are effectively relieved, and wound healing is accelerated. In addition, the rhizoma bletillae and the tea polyphenol can also generate a synergistic antibacterial effect, and compared with a single rhizoma bletillae component, the probability of wound infection is further reduced; the compounding use of the rhizoma bletillae and the tea polyphenol also inhibits the excessive deposition of collagen, reduces the scar area, reduces the scar hyperplasia degree, and makes up the blank of only promoting healing and not preventing scars for burns and scalds in the prior art.

The invention relates to the technical field of medical materials, and discloses a chitosan-based antibacterial dressing and a preparation method thereof. The antibacterial dressing comprises an adhesive tape layer, a dressing surface layer and a protective film, functional dressing liquid is adsorbed on the dressing surface layer, and the functional dressing liquid is prepared from, by weight, 2-4 parts of propolis extract, 1-3 parts of glycerinum, 1-3 parts of alginate oligosaccharide, 0.5-1 part of carbomer, 0.001-0.005 part of growth factors, 2-4 parts of modified chitosan and 3-6 parts of modified gelatin. The modified chitosan is grafted with borneol base and long-chain pyridinium salt, so that reproduction of common pathogenic bacteria can be efficiently and continuously inhibited, and wound infection is prevented; the modified gelatin can shorten the bleeding time of the wound surface and reduce the bleeding amount, and the dressing has good biocompatibility and biodegradability.

The present application relates to the technical field of medical bandage, and discloses a biomass antibacterial hemostatic bandage and a functionalization method thereof.The bandage comprises a bandage base material and a composite antibacterial functional layer loaded thereon, the functional layer is composed of a composite antibacterial unit and lysozyme, and the composite antibacterial unit comprises a cationic antibacterial core, a polyphenol sustained-release shell and an enzymatic cellulose scaffold.The present application forms a biomass antibacterial hemostatic bandage with broad-spectrum, long-acting, low drug resistance and hemostatic function by constructing a cationic antibacterial core-polyphenol sustained-release shell-enzymatic cellulose scaffold composite antibacterial unit and synergistically loading lysozyme.The bandage shows significant technical advantages in dealing with complex wound infection, especially gram-negative bacterial infection and drug-resistant bacterial challenge, and provides an efficient and safe solution for clinical wound management, and has important clinical application value and broad market prospect.

The application aims to provide a preparation method and application of a photocrosslinking zinc-doped baicalin carbon dot-based hydrogel, and belongs to the field of biomedical technology.The baicalin and zinc acetate solution are used as precursors to prepare zinc-doped CDs at 180 DEG C.Meanwhile, a methacrylated gelatin precursor solution is prepared, the carbon dots are added in a certain proportion, and the zinc-doped baicalin carbon dot-based hydrogel is obtained under ultraviolet crosslinking.The carbon dot hydrogel combines the advantages of carbon dots and hydrogels, and has a certain application prospect in wound infection treatment.

A self-powered intelligent adhesive bandage capable of detecting temperature in real time and dosing according to needs is applied to detection and treatment of skin wound infection and can detect the temperature of a wound and surrounding skin in real time and conduct dosing according to needs. According to the intelligent adhesive bandage, the piezoelectric nanometer generator is combined, mechanical energy generated in the daily activity process of a wearer can be converted into electric energy, and the electric energy is used for driving the whole intelligent adhesive bandage to operate. The two temperature measuring units are used for detecting the temperature of the wound and the surrounding skin at the same time, the temperature difference value serves as a relative index for judging whether the wound is infected or not, and the influence of environmental factors on detection is reduced. A three-electrode structure is adopted, on-demand drug delivery is achieved through iontophoresis, and high drug permeability, dosage controllability and drug delivery uniformity are all considered. After the intelligent adhesive bandage is used for treating a mouse with wound infection for three days, the wound recovery rate of the mouse reaches 90.3%, and the realization of temperature detection and on-demand administration is proved. The intelligent adhesive bandage has a good application prospect in detection and treatment of wound infection.

An anus fistula postoperative dressing and medicine putting device, including push tube, outer tube and front end guide tube, the inner cavity of outer tube is equipped with the channel of injection and push, one end of outer tube is rotating end, the other end is insertion end, the side of outer tube close to insertion end is equipped with outer thread, one end of front end guide tube is holding end, the other end is equipped with petal type opening, the inner thread of front end guide tube is equipped with the matching of outer thread, the middle part of push tube is equipped with cavity, one end of push tube is push end, the other end is piston end, the piston end of push tube is inserted from the side of rotating end of outer tube, and the piston end of push tube is sliding connection with outer tube, in initial state, the holding end of front end guide tube is screwed on outer tube, and the insertion end of outer tube is received in front end guide tube, the utility model discloses convenient operation, can control the depth of dressing, reduce the possibility of wound infection and anus fistula recurrence, shorten the wound healing period, reduce the patient's pain.

This invention discloses a near-infrared light-responsive porous membrane, its preparation method, and its applications, relating to the field of dressing technology. The near-infrared light-responsive porous membrane is composed of polyurethane, PDA@ZnO nanoparticles, and the antibacterial agent QCS. Under near-infrared light excitation, this near-infrared light-responsive porous membrane can generate reactive oxygen free radicals and heat, and release biofunctional zinc ions. Addressing the clinical challenges of chronic wounds, such as their susceptibility to infection and slow healing, this invention provides a new approach to improving the clinical treatment of chronic wounds by using a PDA@ZnO / QCS / TPU porous membrane that achieves highly efficient and precise sterilization under the synergistic effect of specific wavelengths of light, thereby preventing wound infection and promoting wound healing.

The application relates to the technical field of intelligent medical treatment, and discloses a surgical operation wound infection nursing management method based on image feature extraction. The method is based on dimension reduction reconstruction and gravity compensation fusion calculation of image extraction, and a single image acquisition action is split into three-dimensional form determination and rheological qualitative synergy gain. Through a core shape flow decoupling strategy, false positive noise introduced by light distortion and terrain undulation is effectively filtered out, and the specificity and robustness of pathological feature extraction under a complex observation domain are greatly improved. The visual research result is directly converted into a space approximation strategy under augmented reality guidance, a micro pneumatic pulse provides non-contact constant physical intervention, and the risk of secondary mechanical damage caused by traditional contact type exploration is avoided. A multiple information collaborative decision-making mode effectively breaks the shock dead loop problem in automatic medical inspection and intelligent micro-path planning.

The invention discloses a medical dressing capable of absorbing moisture and releasing sweat and a preparation method of the medical dressing, and relates to the technical field of medical dressings, the medical dressing comprises a polyurethane copolyester nanofiber membrane, and the preparation method of the polyurethane copolyester nanofiber membrane comprises the following steps: pouring non-isocyanate polyurethane copolyester, levofloxacin and polyacrylonitrile into hexafluoroisopropanol, and stirring uniformly; carrying out electrostatic spinning; and spin-coating a chitosan-gelatin-glycerol mixed solution, and spin-coating a spermidine cross-linking agent to obtain the polyurethane copolyester nanofiber membrane. By introducing the polyglycolic acid-based non-isocyanate polyurethane copolyester and the levofloxacin, the levofloxacin is uniformly dispersed and embedded into a fiber network, so that uniform dispersion and controllable release of an antibacterial drug are realized, growth and reproduction of bacteria at a wound are effectively inhibited, and the problems of wound infection and slow healing are solved; the healing speed is increased; and the complication risk is reduced.

The invention provides a non-dissolution type antibacterial dressing and a preparation method thereof, and relates to the technical field of medical dressings. A non-dissolution type antibacterial dressing comprises a base material, micron-sized antibacterial microspheres and an endotoxin adsorption material, and the antibacterial microspheres and the endotoxin adsorption material are loaded inside and / or on the surface of the base material in one or more modes of physical wrapping, physical winding and chemical bond connection; the base material comprises polyvinyl alcohol fibers and / or chitosan sponge; the endotoxin adsorption material comprises modified styrene divinyl benzene affinity resin nano-structure particles and / or poly (4-methyl-1-pentene) fibers. The antibacterial microspheres can effectively kill bacteria at wounds and inhibit growth and reproduction of the bacteria, the endotoxin adsorption material has strong adsorption capacity, inflammatory response caused by endotoxin is reduced, the risk of wound infection is reduced, the antibacterial microspheres and the endotoxin adsorption material are mutually synergistic in performance, the antibacterial performance is excellent, wound adhesion is avoided, the risk of wound infection is reduced, and the wound healing effect is good. The wound healing is promoted.

The invention discloses a hydrogel dressing with antibacterial property, antioxidant property and pH responsiveness as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of biomedical materials. An aldehyde group generated after ring opening of genipin as a chemical cross-linking agent and an amino group in a high-molecular polymer are subjected to a Schiff base reaction to realize chemical cross-linking, puerarin molecules are self-assembled through non-covalent bonds including hydrogen bonds and hydrophobic interaction, and a gel network is formed; and Ag-coated CR composite nanoparticles synthesized by a microalgae extract and silver nitrate are loaded. The multifunctional hydrogel material provided by the invention has antibacterial, antioxidant and pH-responsive properties, shows excellent antibacterial ability for common pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, and can effectively inhibit wound infection.

This utility model relates to the field of minimally invasive postoperative wound dressing technology, specifically a minimally invasive postoperative wound dressing with wound closure function. It includes an adhesive layer, release paper installed on both sides of the bottom of the adhesive layer, low-sensitivity adhesive tape evenly installed on both sides of the top of the adhesive layer, and a sterilization layer embedded in the middle of the adhesive layer. The improved minimally invasive postoperative wound dressing adds a first elastic band and a second elastic band. When the wound dressing is applied to the wound surface, the first and second elastic bands can be pulled to traction the sides of the adhesive layer, thereby effectively closing the wound, reducing the risk of wound dehiscence, and promoting rapid wound healing. An absorbent layer made of highly absorbent resin is also added, allowing the absorbent layer to quickly absorb tissue fluid exudated from the wound during the healing process, helping to reduce the risk of wound infection and thus promoting wound healing.

The application discloses a dandelion extract capable of neutralizing bacterial toxins and application thereof. The dandelion extract is mainly prepared by the following method: fresh dandelion juice is squeezed, the juice is collected, the juice is centrifuged, the supernatant is collected, the supernatant is ultra-filtered, and components capable of passing through a filter membrane with a molecular weight cut-off of 100 kD and incapable of passing through a filter membrane with a molecular weight cut-off of 3 kD are collected, namely the dandelion extract. The dandelion extract obtained by the application is natural in composition, free of toxic side effects and high in biological activity. Experimental evidence shows that the dandelion extract can protect host cells from attack by directly and specifically combining with toxins, effectively neutralizes the toxicity of bacterial toxins, and has effective prevention and treatment effects on diseases such as systemic bacterial infection, wound infection and bacterial pneumonia. Therefore, the dandelion extract can be used as a new type of anti-microbial and anti-infection functional material and applied to the fields of functional food, health products, medicines or functional cosmetics.

The utility model relates to a wound dressing plaster for a gynecological operation. The wound dressing patch for the gynecologic operation sequentially comprises a seepage absorption and moisture preservation face, a drying layer, an isolation face, a release film and a protection patch from bottom to top, the seepage absorption and moisture preservation face comprises two layers of non-woven fabric, a plurality of rectangular rounded corner environment control patches used for making a humid environment are attached to the outer layer of non-woven fabric, the environment control patches are arranged in a mutually-separated mode, and the protection patch is arranged between the two layers of non-woven fabric. And a gap for adsorbing and pulling out seepage from the wound surface is formed. According to the wound dressing paste for the gynecological operation, seepage is rapidly pulled away and adsorbed and dried in the middle layer in a concentrated mode according to the wound environment characteristics needed by gynecological wound healing, a humid and clean wound environment is provided for a wound, coarse surface isolation is conducted on the outside on the premise that breathability is considered, and wound infection caused by bacterium invasion is effectively avoided.

The invention relates to the technical field of animal husbandry treatment, and discloses an animal husbandry and veterinary animal treatment observation device and a use method thereof. According to the animal husbandry and veterinary animal treatment observation device and the using method thereof, through cooperation of the excrement leakage net plate and the inclined guide plate, animal excrement and urine rapidly fall down and are intensively discharged through the blow-off pipe, and it is avoided that pathogenic bacteria are accumulated and bred in an observation area, wound infection is caused, and the treatment effect is affected; meanwhile, the cleaning assembly achieves all-directional washing in the box through a high-pressure spraying head, the disinfection assembly atomizes a disinfectant and then evenly sprays the disinfectant to cover key parts such as the inner wall of the observation box and a feces leakage net plate, the cleaning and disinfection processes are integrated, cross infection of diagnosis and treatment gaps of different animals is effectively avoided, and an axial fan of the ventilation assembly accelerates air circulation; the temperature in the box can be adjusted in cooperation with an electric heating pipe, and the animals are prevented from catching cold; the temperature and humidity sensor monitors and feeds back data to ensure that the environment in the box is suitable, and good conditions are provided for animal recovery after treatment.

The present invention belongs to the field of biomedical materials technology, and specifically relates to a probiotic hydrogel and its preparation method and application. The probiotic hydrogel comprises a hydrogel substrate formed by oxidized methylmalonamide hyaluronic acid; and the hydrogel substrate is cross-linked with probiotics and extracellular polysaccharides secreted by the probiotics, wherein the probiotics are Lactobacillus acidophilus. L. acidipiscis 10851 , the extracellular polysaccharide is L. acidipiscis 10851 The probiotic hydrogel of the present invention is suitable for various traumas and surgical wounds, and can stop bleeding, reduce wound infection and promote wound healing.

This invention belongs to the field of medical technology, specifically relating to a tandem controlled-release nucleic acid nanoprobe composite hydrogel and its application in the diagnosis and treatment of wound infections. First, the invention modifies the surface of gold nanoparticles with nucleic acid sequences via Au-S bonds to prepare a DNA-gold nanoparticle probe (NAFP), achieving highly specific detection of sulfides, a wound infection marker. Then, using mesoporous silica as a carrier, an antibacterial drug is loaded, constructing mesoporous silica D@MSNs loaded with a double-stranded DNA molecule valve-type bactericide. Subsequently, the NAFP and D@MSNs are formulated into a gel to obtain a therapeutic dressing. This dressing can trigger conformational changes in nucleic acids through infection markers, achieving precise matching of drug release to the degree of infection, thereby enabling in-situ detection of bacteria. It also possesses highly efficient antibacterial activity, physical protection, and moisturizing functions. The dressing is easy to operate, has low clinical translation costs, and is suitable for the diagnosis and treatment of acute and chronic wound infections, showing broad application prospects.

The invention belongs to the technical field of antibacterial materials, and particularly relates to a zwitterionic photosensitizer material, nanoparticles and a preparation method and application of the zwitterionic photosensitizer material and the nanoparticles. The structural formula of the zwitterionic photosensitizer material is shown in the specification, wherein x is any integer between 3 and 5; r1 and R2 groups are shown in the specification. The zwitterionic photosensitizer material based on sulfonation has excellent hydrophilicity and biological activity, can achieve an efficient sterilization effect at a low dosage, and has efficient curability on mouse living body wound infection, so that the zwitterionic photosensitizer material can be used for preparing a medicine for treating wound infection, and the problems that in the prior art, aggregation causes a fluorescence quenching effect, and the toxicity is poor are solved. And the problem of poor antibacterial treatment effect caused by reduction of ROS yield due to aggregation is solved.

The invention provides a hydrogel wound dressing capable of rapidly stopping bleeding. The hydrogel wound dressing is prepared from the following components in percentage by mass: 10 to 15 percent of polyethylene glycol, 5 to 10 percent of oxidized konjac glucomannan, 0.1 to 0.3 percent of cannabidiol, 0.5 to 2 percent of polydopamine nanoparticles, 8 to 12 percent of tannic acid modified carboxymethyl chitosan and the balance of corn starch. According to the hydrogel wound dressing, through cooperation of all the components, rapid hemostasis can be achieved, and the hydrogel wound dressing is especially suitable for domestic standing scenes, convenient to use and capable of rapidly stopping bleeding, reducing wound infection and easing pain.

The present application provides a kind of hydrogel dressing with photothermal / photodynamic synergistic antibacterial activity and its preparation method, belong to biological medical tissue engineering material technical field, the present application is by the indocyanine green (ICG) with photodynamic (PDT) treatment ability and the hollow prussian blue nanoparticle Pt-HPB with photothermal treatment ability doped with platinum as photosensitizer, combined with the hydrogel made of oxidized sodium alginate and polylysine, these antibacterial nanoparticles are supported by the hydrogel with good water dispersibility, a kind of composite hydrogel (Pt-HPB-BSA & ICG@Gel) with photothermal photodynamic synergistic antibacterial ability is prepared, as the medical dressing of wound infection antibacterial treatment and promoting wound repair.