1018 results about "Wound infection" patented technology

A system and a method topically applies nitric oxide to an infected area of tissue to treat a wound or lesion to prevent infection, reduce pathogen levels in the infected area and promote healing. The basic system includes a source of nitric oxide gas and a flushing envelope. The flushing envelope is applied to an animal to cover a wound and receives nitric oxide from the source via a flow control valve. One form of the system includes a vacuum unit fluidically connected to the flushing envelope, and one embodiment includes a gas absorber unit. The flushing envelope is adapted to surround the area of the infected tissue and form a substantially air-tight seal with the tissue surface when the flushing envelope is in place on the animal. The flow control valve controls the amount and concentration of nitric oxide gas that is delivered to the flushing envelope. A source of dilutant gas is fluidically connected to the flow control valve and a system control unit transmits and receives signals from various sensors and controlled elements in the system. NO and NO2 sensors are included in one form of the system.

The invention discloses a porous complex gel-nanofiber oxygen permeation dressing and a preparation method thereof. The method comprises the following steps: obtaining a collagen nanofiber membrane by adopting a collagen solution by virtue of an electrostatic spinning method; performing chemical crosslinking on two natural and non-toxic macromolecule polysaccharides such as chitosan and alginic acid, and preparing complex gel; and preparing the porous sponge-nanofiber double-layer composite material in a freeze-drying mode, wherein the upper gel layer of the dressing is in a sponge state during drying and is in a gel state after moisture absorption. The biological wound dressing is prepared under the condition that any toxic chemical crosslinking agent is not added, the process is simple, and the safety is high. The prepared biological wound dressing disclosed by the invention has the characteristics of excellent oxygen permeation performance, water-absorbing quality, water permeability, moisture penetrability and high biocompatibility, a physiological wet environment of the wound surface can be maintained, wound healing and effective haemostasis are promoted, wound infection can be avoided, the recovery is accelerated, the wound surface can be effectively recovered, and the dressing is applied to multiple wound surfaces such as trauma, burns and ulceration.

The invention relates to a suture line containing bioactive ingredients and a preparation method thereof. The suture line is prepared by a plurality of superfine fibers with biocompatibility through the coaxial cospinning technology and after-treatment, and the plurality of the superfine fibers are biodegradable materials, wherein at least one superfine fiber is a composite superfine fiber with acore-shell structure; a core comprises the bioactive ingredients; and a shell is a biodegradable material. The suture line containing the bioactive ingredients has the advantages that the suture linecontaining the bioactive ingredients aims to realize wound suture and avoid wound infection caused by secondary operation; the biodegradable materials are taken as substrate materials and as shell layer materials of the coaxial cospinning composite superfine fibers, and different bioactive ingredients are packaged into core layers; and the diameter, the structure and the mechanical property of the suture line and the release property of a medicine and so on are controlled by adjustment of the processing parameters, so that the prepared suture line meets the suture requirements of various different tissues, not only can suture the wound but also can reduce infection, and has the function of treatment.

The invention relates to a chitosan nano silver gelata used for treating an inflammation in a lower genital tract, cervicitis and cervical erosion of female and empyrosis, scalding, bedsore infection and other skin inflammations such as tinea manus and pedes, and various wound infections, etc. The medicinal raw materials of the chitosan nano silver gelata of the invention are the nano silver and chitosan polymer in respective therapy dose; the nano silver is the nano silver powder or the nano silver colloid; the chitosan polymer is the chitosan and the chitin and one or more than one derivative of the chitosan and the chitin. The product of the invention has the advantages of high efficiency and being nonpoisonous, and has an extremely strong antibacterial action and an excellent therapeutic effect; compared with other nano silver gelata, the chitosan nano silver gelata of the invention has the advantages of perfect sterilizing effect, long-lasting effect and tissue repair function.

Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and / or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.

The invention relates to a medical hydrogel dressings and a preparation method thereof. The hydrogel dressings is prepared by taking 10-30% by mass of starch and 2-15% by mass of water-soluble polymer as raw materials, utilizing a guanidinesalt polycondensate as an anti-bacterial agent, adding a cross-linking agent, and reacting at the temperature of 40-80 DEG C. The operation steps are as follows: adding the starch and the water-soluble polymer in a solvent to prepare into a solution, regulating the pH value of the solution by a NaOH solution, heating for gelatinization, cooling, adding the anti-bacterial agent and the cross-linking agent, stirring to form a mixed solution, pouring the mixed solution into a die, and reacting at the temperature of 40-80 DEG C to obtain the anti-bacterial hydrogel. Compared with the prior art, the hydrogel dressings in the invention has the advantages of good swelling property, high transparency, moderate mechanic strength, excellent bacteria invasion resistance, wide raw material sources, cheap raw materials, good tissue compatibility and favorable medical application prospect, and can effectively prevent wound infection.

The invention discloses a medical wound dressing which is loaded with antibiotic nanometer particles and which is in a spongy state when being dried and in a gel state after absorbing the moisture; the medical wound dressing is fixed in a spongy membrane prepared by chitosan and natural high molecular polymers and derivatives of the chitosan with the proportion of 10 to 19 percent of the spongy membrane and natural polymers by drug-loading nanometer particles; the drug-loading nanometer particles contains antibiotics with the particle size of 100nm to 1000nm, the encapsulation rate of 50 to 98 percent and the drug-loading rate of 5 to 60 percent and the weight percentage of 2 to 10 percent of the drug-loading nanometer particles in the wounding dressing. Combing the sustained and controlled release characteristic and the advantage of polysaccharide membrane, the invention has high water absorbability, air permeability, moisture permeability and good biological compatibility can keep the wound physiological moisture environment and promote the wound to recover and has hemostatic effect; at the same time, the invention has good slow release performance for the antibiotics, can prevent the infection of the wound and accelerate the recovery, thus being suitable for a plurality of wounds such as the traumas, burns and ulcers.

The invention provides an antibacterial hydrogel composite material and a preparation method thereof. The antibacterial trauma repair material is hydrogel formed by chitosan and gamma-polyglutamic acid according to a mass ratio of 1 / 0.5-2 through electrostatic interaction, and nano silver is synthesized and loaded in situ on the hydrogel by taking PVP as a dispersant. the preparation method is simple, convenient and quick, and the trauma repair material is high in practicability. The composite hydrogel trauma repair material integrates bactericidal and immune activity, high biocompatibility and hemostatic activity that chitosan has, high water absorbency that gamma-polyglutamic and broad-spectrum antibacterial property and freeness of drug resistance that nano silver has, and composite hydrogel nano silver is small in grain diameter, uniform in distribution and less prone to aggregation, thereby having high antibacterial performance; when the material is used for wound dressing, wound infection can be avoided effectively, and wound healing can be accelerated.

A non-invasive, calorimetric infection detector is provided, comprised of a substrate, and one or more indicator compositions disposed upon or incorporated therein. These indicator compositions exhibit a persistent change color when exposed to gaseous oxides of nitrogen and acids formed therefrom, providing a means of detecting NO production in a wound, which has been found to occur at a high level at the onset of infection in a wound. In addition, a bandage is provided, comprised of the detector, as well as a porous portion, and preferably a hydrophobic barrier layer to protect the detector from contamination by water and other fluids draining from the wound. The non-invasive, calorimetric infection detector, and bandage containing same, can be utilized to provide a convenient, easily utilized colorimetric means of detecting the onset of wound infection, thereby enabling caregivers to effectively and timely treat infections.

A probiotic enzyme ecological-restoration composition uses centella asiatica as a main raw material, uses multiple Chinese herbal medicines including angelica sinensis and the like and food materials as auxiliary materials and is prepared by performing aerobic fermentation and anaerobic fermentation, adding filtrate emu oil, badger oil and horse oil and performing homogeneous processing. The probiotic enzyme ecological-restoration composition can expand the intercellular space of the skin, dredge pores and loosen sweat ducts, promotes the skin to absorb a large amount of beneficial nutritional substances in the composition so as to play the special effects of modification, moisture preserving, moisturizing and immunity enhancement, can rapidly repair the skin, has the obvious effect on scalds, wound infection and scar repair and can also serve as a daily skin care products.

The invention discloses genipin cross-linked biogel as well as a preparation method and application thereof. The genipin cross-linked biogel comprises the following raw materials in percentage by weight: 0.05wt%-0.2wt% of genipin, 1wt%-10wt% of matrix and the balance of water. By carrying out crosslinking by virtue of optimized genipin concentration, the obtained biogel has the properties of low toxicity, good water-absorbing property and mechanical property and the like. The biogel can be directly used for protecting and isolating the surfaces of various wounds, bedsores and ulcers, can be used as a dressing carrier to load antibacterial drugs, paregorics, growth factors and the like, and can be applied to the treatment of wound infection, wound analgesia or promotion of wound healing and the like. According to the genipin cross-linked biogel, the matrix, a crosslinking agent and the components are all derived from natural organisms, so that the biogel is safe and non-toxic and can be widely applied to the treatment and repair of clinical acute and chronic wounds.

The invention provides an external traditional Chinese medicine preparation for treating chronic wounds, which is prepared from the following raw medicines in parts by weight: 10-20 parts of draconis sanguis, 10-20 parts of chuanxiong rhizome, 10-20 parts of notoginseng, 10-20 parts of fried sanguisorba, 10-20 parts of safflower, 10-20 parts of spatholobus stem, 10-20 parts of giant knotweed, 10-20 parts of oldenlandia, 10-20 parts of red sage root, 10-20 parts of herba patriniae, 10-20 parts of moutan bark, 10-20 parts of myrrh, 10-20 parts of mastic, 10-20 parts of rhubarb, 10-20 parts of natural indigo, 10-20 parts of gromwell, 10-20 parts of catechu, 10-20 parts of borneol, 10-20 parts of phellodendron bark and 10-20 parts of boneset. The external traditional Chinese medicine preparation provided by the invention can promote healing of infectious wounds, increase pus, enhance qualitative viscosity and regenerate granulation to enable the wounds to quickly heal, has an obvious effect on treating wound infection, and can be used for treating partial ulcer, removing necrotic tissue and promoting granulation, accelerating the degeneration process of the necrotic tissue, promoting dilation of capillary vessels, accelerating microcirculation of the capillary vessels and filling the wounds.

The invention relates to a medical biological dressing, particularly to a medical biological scar-inhibiting rhytidectomy dressing and a preparation method thereof. The dressing is composed of modified chitosan, silicone, glycerol, camellia oil, olive oil, almond oil, an aloe extracting solution, active growth factors, hyaluronic acid and a ginger extracting solution. With adoption of the formula, skin regeneration organs are retained and activated furthest, and a good foundation is laid for wound repair. The formula is reasonable and scientific and has the efficacies of clearing away heat and toxic materials, removing slough and promoting growth of tissue regeneration, promoting blood circulation and removing blood stasis, and relieving swelling and pain on scars, has an impressive preliminary therapeutic effect on scars of skin epidermis bruise, trauma, traumatism, burning, scald, and post-operation wound, has the advantages of high efficacy, rapid pain relieving, low possibility of infection, simple preparation method, and good convenience in usage and popularization, and is used for burning, scald, trauma, bruise, traumatism, post-operation wound hemostasis, inflammation diminishing, pain relieving, wound infection prevention, scar inhibition, skin wrinkle and crack prevention, and wrinkle inhibition.

The invention belongs to the field of biomedical engineering materials and discloses a nitric oxide loaded cationic polymer, a preparation method therefor and an application of the nitric oxide loaded cationic polymer in the field of biomedicine. A cationic polymer which is used for loading nitric oxide and containing a dendritic polyamide element specifically is a polyethyleneimine grafted dendritic polyamide polymer and has a molecular formula shown in the description. The invention further provides the nitric oxide loaded cationic polymer based on the polymer. The nitric oxide loaded cationic polymer disclosed by the invention can be applied to the field of biomedicine as a nitric oxide donor material through loading NO, is used as a biomedical material and particularly is applied to the preparation of antibacterials; and the nitric oxide loaded cationic polymer has the effects of effectively inhibiting the growth and reproduction of bacteria and fungi, has remarkable inhibitory effects on common oral cavity pathogenic bacteria, dermatophyte, wound infection bacteria and the like, has the functions of promoting wound healing, diminishing inflammation and the like and provides a support for the application of the nitric oxide loaded cationic polymer in preparation of the biomedical engineering materials.

The invention relates to an antibacterial fiber dressing containing nanometer metal and a preparation method thereof. Nanometer metal particles are distributed on the fiber surface of the dressing. The content of the nanometer metal is 0.5-10 wt%. As a dressing for wound treatment, the fiber wound dressing has the capability of continuously releasing sufficient nanometer metal particles, is especially suitable for chronic wound treatment, can provide long-term and effective antibacterial functions, and can effectively prevent wound infection caused by various bacteria and microbe.

A Chinese medicine external-use preparation medicament for treating surgery wound infection and a method for producing the same. The medicament has the raw materials of pangolin scales, dragon's blood, notoginseng, red halloysite, frank incense, myrrh, artificial mercuric sulphide, black catechu, pearl powder, drgon's bones, calomelas, borneol and gingelly oil. The medicament is mild in temperament, has no toxicity and side effect and is easy for dressing change. The prescription activates blood and resolves stasis, regenerates tissue, tonifies qi, benefits blood, takes temporary solution and effects a permanent cure. The producing method need simple facilities, saves energy and water, has short production period, low cost and no pollution and solves the adverse reaction in the surgery usual wound infection treatment due to frequently externally changing applied medicament and frequently removing necrosis infection tissue.

A toothbrush includes a head capable of producing a certain wavelength of light such that when the user is brushing teeth, the light from the head will kill bacteria, enhance blood circulation, vitalize tissues, improve tissue reproduction and repair, and reduce the risk of oral diseases and wound infection in his mouth.

The invention discloses a medical composite chitosan gel containing antibacterial drugs. In parts by weight, the medical composite chitosan gel comprises the following components: 0.5 to 10 parts of chitosan polymer materials, 0.05 ~2 parts of antibacterial drug, 0~10 parts of thickener, 1~25 parts of humectant and 53~98.45 parts of purified water. The medical composite chitosan gel containing antibacterial drugs of the present invention can effectively maintain a moist environment for wound healing, promote wound healing and prevent and control wound infection. The drug combines the advantages of chitosan polymer materials such as moisture absorption, moisturizing, antibacterial, and hemostasis with the role of antibacterial drugs in preventing and controlling infection, and prepares a gel with excellent performance.

Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the α 1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and / or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.

The invention provides a method for preparing flamazine / bacterial cellulose composite wound dressing, which comprises the following steps of: performing pretreatment and purification treatment on a bacterial cellulose membrane to obtain purified bacterial cellulose; preparing flamazine suspension with the granularity of 50 to 5,000 nm under dark condition; reacting the bacterial cellulose membrane with the flamazine suspension to form a flamazine / bacterial cellulose composite membrane; and performing drying treatment to obtain a dry flamazine / bacterial cellulose composite membrane, or performing extruding dehydration to obtain a wet flamazine / bacterial cellulose composite membrane with different water content values to prepare the flamazine / bacterial cellulose composite wound dressing. The prepared flamazine / bacterial cellulose composite wound dressing has high mechanical performance, high antibacterial property, and high water and air permeability or good drainage and moisture absorption effects, can promote the drying, scabbing and healing of wound, and is used for preventing and treating the secondary wound infection of second-degree and third-degree burn or scald.

The invention relates to the technical field of a traditional Chinese medicine preparation, and particularly discloses externally-applied skin-generating oil for treatment of burns and a preparation method and application thereof. The skin-generating oil is prepared by soaking the following 15 Chinese herbs in sesame oil: radix scutellariae, rheum officinale, astragalus mongholicus, coptis chinensis, cortex phellodendri, angelica sinensis, sanguisorba officinalis, lithospermum, rehmannia, radix angelicae, cynanchum atratum, bletilla striata, olibanum, myrrh and borneol. When the skin-generating oil is applied in treatment of burns, wound infection caused after injury can be prevented effectively, proliferation and migration of fibroblasts and vascular endothelial cells can be promoted, neovascularization can be induced, wound healing can be accelerated, scar repair can be promoted, the wound healing time can be shortened, Class I-II burns can be cured in 10-12 days, and Class III burns of rabbits can be cured in 20-25 days. When Class III burns of rabbits are treated with the skin-generating oil, the wound area can be reduced from 6 cm<2> to 0.1cm<2>, the wound surface is flat, smooth and soft, and newborn hair is normal. The wound epidermis can be recovered completely, dense hair follicles can be formed in the dermis layer, and almost no difference from normal skin tissues can be produced.

The invention is a postoperative binder and method of use. The binder is made of relatively inelastic material that is cut to fit the patient and held in place by a plurality of tails fastened with Velcro(R) binders. The present invention uses mechanical, rather than elastic, compression. Mechanical loads are carried over the iliac crest, by hooking the tails of the binder over the iliac crest and then bifurcating the tails for attachment to the abdominal portion of the binder. The present invention provides support of lower abdominal tissue, especially near the genitals and in the area of the peritoneum. The invention is also a method of preventing post-operative wound infection, reducing incidence of seroma and hematoma formation and wound separation while reducing pain and the need for pain medication by passing a relatively inelastic abdominal binder over the patient's iliac crest and abdomen to place the binder in tension so as to provide a greater than 180 degree radius of compression to the wound.

The invention discloses an auxiliary skin wound healing device and particularly provides an auxiliary skin wound healing device used in the field of medical treatment and public health. The auxiliary skin wound healing device can timely clean the skin wound, remove the dead space at the position of the skin wound, prevents wound infection and inflammation, promotes skin healing, prevents skin turnup or wraping in the skin healing process and enables the healed skin to be more regular and flat. A locking structure is arranged on a negative-pressure cavity. A drainage pipe is utilized to suck air inside the negative-pressure cavity to the outside of the negative-pressure cavity. The auxiliary skin wound healing device comprises a sealing membrane, the drainage pipe, base bands, an opening sealing end and an elastic upper cover, wherein the skin wound and the outside environment can be effectively isolated through the sealed cavity, and the sealed cavity enables the skin wound to be kept clean. A negative-pressure environment can be formed inside the sealed cavity, no skin turnup or wraping phenomenon occurs in the skin healing process, and the skin is always kept in a regular and flat form in the healing process.

A medical gauze sensor system for preventing the medical gauze from being left in human body after operation features that an electronic label with its UID and / or cipher is installed in the medical gauze for tracking it easily.

The invention discloses an electronic nose signal processing method based on a mixing characteristic matrix. The method comprises the steps that first, characteristic extraction is conducted on an original data matrix to establish the mixing characteristic matrix, then a binary quantum particle swarm optimization algorithm is used for conducting characteristic selection on the mixing characteristic matrix, at last, the mixing characteristic matrix is fed into a classifier, a decimal quantum particle swarm optimization algorithm is used for conducting synchronous optimization on mixing characteristic sub matrixes and the parameters of the classifier, mode recognition is conducted to determine the mixing characteristic sub matrix with the highest recognition rate, and the sensor characteristic corresponding to the mixing characteristic sub matrix is selected to be used as the optimized characteristic of an electronic nose signal for conducting mode recognition. The electronic nose signal processing method based on the mixing characteristic matrix has the advantages that the defect that the complete information of an entire response curve can not be reflected only by extracting a single characteristic is overcome; the operation complexity is lowered, the problem of redundancy between sensors is effectively solved, the recognition rate of wound infection detection of an electronic nose is improved, and beneficial guidance can be provided for a doctor to choose a proper treatment method.

The present invention discloses a pearl nucleus processing method for culturing nucleated pearl which comprise the following steps: (1)Choosing pearl nucleus of 12-17mm diameter, (2) purifying pearl nucleus, washing pearl nucleus with 5-10% dilute hydrochloric acid, then washing repeatedly with limewater until the pearl nucleus is neutral in pH, placing pearl nucleus in boiled water for disinfection; (3) activating the immersed pearl nuleus, placing pearl nucleus in activation liquor and processed pearl nucleus is obtained. The present invention purifies the pearl nucleus and activate the pearl nucleus before transplanting that effectively promote the tropism of pearl oyster to pearl nuclus reduce the cut infection probability of nucleus-transplanting tissue quick the healing rate of wound, promote the forming quality of pearl sac, reduce the surface blemish forming rate of nucleated pearl, promote the yield of nucleated pearl.

The invention discloses a sustained-release sticking film for treating oral ulcer and relates to the technical field of medical equipment and preparation technology thereof. The sustained-release sticking film is of a circular sheet and provided with a three-layer structure, wherein the upper layer is a sustained-release coating (1) which contacts with an oral ulcer surface, the lower layer is a polyacrylic acid film (3) with a protective effect, a medicament-loaded layer of the middle layer takes bacterial cellulose as a medicament carrier, and a medicament loading substance with a sustained-release effect enters a bacterial cellulose membrane by using a dipping method to obtain a bacterial cellulose / medicament loading substance composite film (2). The sustained-release sticking film disclosed by the invention is good in adhesion, permeability and biocompatibility, large in medicament loading capacity, long in local effect time, capable of relieving pain, promoting wound healing and preventing wound infection. The sustained-release sticking film is suitable for oral traumas of oral ulcers, oral mucosal bites and the like.

A method for breeding seed konjac from konjac corms through segmenting with a lateral bud is disclosed. The specific method and the benefits thereof are as follows: the terminal bud of each konjac corm before overwintering storage is removed so as to start and promote the physiological activity of lateral buds in the overwintering period; after overwintering, the konjac corm is segmented so that the dominant lateral buds of the corm are more obvious; after transverse cutting of the corm, the corm is vertically cut so that the upper half part of the corm is divided into four pieces, thereby ensuring that each piece is provided with the dominant lateral bud and also ensuring that the weight of each piece is between 50 g and 80 g; therefore, the expansion coefficient of each segment is increased when enough nutrients for survival are present; before seeding, dormancy breaking and germination acceleration are performed so as to germinate the segments in advance; as a result, the growth period is prolonged; in addition, diseased seeds can be discovered before seeding to avoid losses; an appropriate cultivation method is capable of accelerating the konjac to sprout and come up out of the ground as soon as possible; a konjac dedicated callusing chemical and a seed konjac dedicated segmenting cutter are used, thereby avoiding wound infection; and a systematic breeding method through segmenting with the lateral bud is capable of increasing the survival rate and the expansion coefficient and improving the economic benefit.

The invention provides a medical dressing, a preparation method of the medical dressing and the preparation method of a dressing plaster. The medical dressing comprises spirulina, spirulina extract and Chinese herbal medicines, wherein the spirulina extract comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ions and vitamins. The dressing plaster comprises a base layer, a bonding layer, an absorbing layer and a treating layer which are stacked sequentially, wherein the treating layer contains the dressing. The dressing comprising the spirulina and the spirulina extract has the treatment functions of stopping bleeding, promoting wound healing, killing and inhibiting bacteria, relieving pain and the like, and can be used for preventing wound infection. The dressing plaster has the functions of the dressing and is easy to use.

The invention relates to a chitosan gel haemostatic material and a preparation method thereof. The chitosan gel haemostatic material is compounded of chitosan, a cross-linking agent and thrombin. The chitosan gel haemostatic material disclosed by the invention is good in biocompatibility and biodegradability; hydrogel is excellent in mucous membrane viscosity and self-adaptability, and has functions of quickly stopping blooding in body, promoting wound healing and releasing thrombin slowly so as to prevent secondary blooding caused by postoperative motion; meanwhile, the haemostatic material has characteristics of bacteria resistance and bacteriostasis and is capable of effectively preventing wound infection.