11results about How to "Guaranteed therapeutic effect" patented technology

The utility model relates to the field of anal fistula drainage tube discloses a telescopic anal fistula drainage tube, including the pipe body, the pipe body front inner wall sliding connection has the extension pipe, the pipe body outside passes through and is opened the drainage hole, the pipe body inner wall is provided with the stretching mechanism, the stretching mechanism includes the limiting component and the support component, the limiting component includes the fixed part, the fixed part fixedly connected in the pipe body inner wall, the pipe body inner wall fixedly connected with the limiting bead, the extension pipe outside sets up the limiting slot, and the limiting bead is connected in the limiting slot inside. In the utility model, by pulling the extension pipe makes, the extension pipe is extruded to the limiting bead through the limiting slot, drives the pipe body deformation to remove the limiting of extension pipe, and at the same time, the deformation of the pipe body is limited through the fixed part, is convenient for the limiting of extension pipe, makes the extension pipe can be length adjusted according to the actual condition of patient, improves the applicability of the device, guarantees the treatment effect.

This invention discloses a humanized voice intervention method for inhalation errors in nasal and oral aerosol delivery devices, aiming to address the lack of humanization in existing voice intervention methods, which leads to patient misunderstanding and resistance. The method includes: establishing a patient-doctor corpus by combining expert experience, literature, and guidelines; fine-tuning a language parsing model to obtain an error-sensitive parsing model; using the error-sensitive parsing model to obtain a total intervention feature library and an urgency level sub-library; establishing a two-level query mechanism for patient inhalation errors to query intervention text in the urgency level sub-library; and fine-tuning the voice generation model based on the aforementioned patient-doctor corpus, incorporating new tokens, and evolving through prompting learning into a patient-friendly intervention voice generation model capable of generating intervention voices that are appropriate for the urgency level. The intervention voices generated by this invention can form a humanized voice intervention that approximates the tone of clinical medical staff, and can adapt the tone according to the urgency level of the error, effectively improving the patient's understanding and acceptance of the intervention suggestions.

The invention discloses an application of a Lamp2b-IMTP fusion exosome in treatment of coronary heart disease. The specific application method comprises the following steps: preparing an exosome matrix, carrying out optimization treatment on the exosome matrix, and finally, specifically combining the optimized exosome matrix with myocardial cells through IMTP on the surface of the Lamp2b-IMTP fusion exosome in an intravenous injection administration mode. Therapeutic substances are accurately delivered to damaged myocardial tissues, which is the core advantage of the fused exosome and is also the basis of subsequent treatment effects: IMTP (myocardial targeting peptide) is modified on the surface of the exosome, and the IMTP can be accurately combined with a specific receptor on the surface of a damaged myocardial cell.

The utility model relates to the technical field of vitiligo therapy instrument shielding, especially a kind of adjustable auxiliary shielding device for vitiligo therapy instrument, the adjustable auxiliary shielding device for vitiligo therapy instrument includes: treatment head, controller is fixedly connected in treatment head top, gripping handle is fixedly connected in treatment head one side, treatment lamp tube is fixedly connected in treatment head inside, protective cover is rotatably connected in the end of treatment head away from gripping handle, limit block is fixedly connected in the side of protective cover close to gripping handle, limit slot is arranged in the inside of limit block, shielding plate is installed in treatment head bottom equidistantly, telescopic plate is installed in treatment head bottom equidistantly, guiding column is fixedly connected in the top of shielding plate, limit component is installed in gripping handle inside, drive component is installed in treatment head inside, the adjustable auxiliary shielding device for vitiligo therapy instrument provided by the utility model has the advantages that controller is protected, and the convenience of use is improved.

This invention discloses a mesh-like phototherapy device and its fabrication method. The mesh-like phototherapy device includes: a substrate layer comprising multiple substrate strips extending along a first direction; the multiple substrate strips are arranged sequentially at intervals along a second direction; the first direction and the second direction intersect each other; a sensor layer located on one side of the substrate layer; the sensor layer comprising multiple strip-shaped sensors extending along the second direction; the multiple strip-shaped sensors are arranged sequentially at intervals along the first direction; wherein, the substrate layer and the sensor layer constitute a mesh structure; a phototherapy luminescent layer located on the side of the sensor layer away from the substrate layer; and a protective layer located at least on the side of the phototherapy luminescent layer away from the substrate; the protective layer is used to protect the phototherapy luminescent layer. The mesh structure formed by the substrate layer and the sensor layer improves the air permeability of the phototherapy device while maintaining good bending performance, thus ensuring the therapeutic effect of the device.

The present application relates to the technical field of surgical knives, and discloses a trabeculectomy knife with adjustable knife distance, which comprises a knife handle, a knife rod connected with the knife handle, and a knife head connected at the end of the knife rod, wherein the knife head is boat-shaped, has a knife tip and two side edges, the rear sections of the two side edges are connected and the front ends thereof meet at the knife tip, the knife head has a concave cavity, the concave cavity is provided with a chevron-shaped gap for separating the knife tip, a pair of parallel first sliding grooves are arranged in the side wall of the concave cavity, an arc-shaped plate is slidably arranged in the first sliding grooves, and the two parallel edges of the arc-shaped plate are respectively clamped in the two first sliding grooves. The trabeculectomy knife can realize mode switching of the knife head and width adjustment of the side edges by single-handed holding, the big thumb can accurately control power transmission by rotating the knob, the friction fit of the threaded transmission and the wedge structure ensures smooth movement without slipping, and the operation difficulty is reduced without the need for additional instrument assistance or double-handed operation.

This utility model discloses a proper limb positioning pad, comprising: a support plate, the support plate including a plate body, the outer side of which is covered with a protective sleeve; a hand restraint component, which is disposed at the upper end of the support plate for fixing the patient's hand; an arm restraint component, which is also disposed at the upper end of the support plate for fixing the patient's arm; the hand restraint component includes a connecting cloth piece, the upper end of which is fixedly connected to five finger restraint straps, and the lower end of which is detachably connected to the support plate via a first connector; the arm restraint component includes a strap, one end of which is fixedly connected to one side of the support plate. This utility model provides a proper limb positioning pad, which, through the structural design of the support plate, hand restraint component, and arm restraint component, enables the device to achieve proper limb positioning for the patient, thereby avoiding the need for multiple pillows that could affect the patient's rehabilitation treatment effect. Its overall structure is relatively simple, easy to use, ensures treatment effectiveness, and reduces the workload of medical staff.

This invention discloses a nebulization device for traditional Chinese medicine (TCM) internal medicine, belonging to the field of medical device technology. It includes a mask assembly, a main nebulizer assembly, and a control panel. The mask assembly is detachable and connects to the main nebulizer assembly, while the control panel centrally controls all components. The mask assembly features a negative pressure suction structure. The main nebulizer assembly integrates an nebulizer, a pressurization chamber assembly, a pump assembly with a conical filter head, and an air supply assembly. A heating element is built into the connecting pipe, and a one-way valve is installed at the pipe connection. The pump rollers are covered with rubber pads. This device features a securely fixed mask, fine and thorough atomization of the medication, and can assist in medication delivery and heating. It is suitable for different patients, and its modular design facilitates cleaning and maintenance, improving medication efficacy and patient experience, thus meeting the clinical needs of TCM internal medicine nebulization.

The utility model discloses a kind of anti-pressure sore inflatable heel protection pads, including horizontal pipe and two U-shaped air bags, two U-shaped air bags are located at the both ends of horizontal pipe, horizontal pipe is set between two U-shaped air bags, movable sleeve joint has movable rod in the both ends inside of horizontal pipe, the end of movable rod away from horizontal pipe is fixedly connected with corresponding U-shaped air bag, the end of movable rod close to horizontal pipe is internally provided with cavity, the inside of the cavity is provided with the limiting mechanism that can limit movable rod relative horizontal pipe movement, the top of horizontal pipe is provided with U-shaped hook, the upper side of the middle end of horizontal pipe is provided with the adjusting mechanism of adjusting U-shaped hook height. The utility model can effectively lift heel by air bag, reduce the pressure of heel part, prevent the occurrence of pressure sore.

This invention discloses an inhalation device and application for anti-cancer and cancer-suppressing traditional Chinese medicine, belonging to the technical field of inhalation devices for traditional Chinese medicine. It includes a telescopic corrugated cylinder and an adaptive stirring assembly. The telescopic corrugated cylinder has multiple telescopic sleeves inside, and the adaptive stirring assembly includes a motor box threadedly connected to the bottom of the telescopic corrugated cylinder. This anti-cancer and cancer-suppressing traditional Chinese medicine inhalation device and application flexibly adjusts the internal space of the device according to the actual volume of the traditional Chinese medicine powder. This effectively avoids wasting space within the container and significantly reduces the overall size of the device by compressing the telescopic corrugated cylinder, improving portability and making it more suitable for daily use. The adaptive stirring assembly can adjust its structure synchronously with the telescopic corrugated cylinder's extension and retraction, always matching the internal space of the container to ensure comprehensive stirring of the powder. This allows the medicinal aroma to be evenly distributed and fully volatilized, eliminating the need for frequent manual shaking of the container. This ensures more even administration of the traditional Chinese medicine aroma, guarantees the therapeutic effect of inhalation, and significantly optimizes the user's operating experience.

The present application relates to a kind of plasma markers GPNMB for predicting the curative effect of esophageal squamous cell carcinoma immunotherapy and its application, for screening predictive biomarker, we carry out plasma proteomics analysis, identify soluble glycoprotein non-metastatic melanoma protein B (sGPNMB) as the most significant circulating protein in treatment non-response patient is elevated, and through experiment determines, in humanized PDX model, the level of circulating GPNMB can predict PD-1 blocking curative effect, and inhibition GPNMB can enhance treatment effect.The method of the present application can realize the stratified management of esophageal squamous cell carcinoma patient, before carrying out immunotherapy, the plasma GPNMB level of patient is detected, can predict the subsequent treatment effect, and then screen out the patient suitable for immunotherapy and carry out treatment, ensure treatment effect, for the patient who is not suitable for immunotherapy can select other treatment scheme, realize the targeted effective treatment of different patients.