Targeted drug release intervened medical appliance and preparation method thereof

A technology for medical devices and drugs, applied in the field of medical devices, can solve the problems affecting the drug treatment effect of the device and low surface bonding strength, and achieve the effects of good drug treatment effect, high bonding strength, and ensuring the drug dosage range.

Active Publication Date: 2014-07-30
上海赢生医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a targeted drug release interventional medical device and its preparation method, which solves the problem that the drug c

Method used

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  • Targeted drug release intervened medical appliance and preparation method thereof
  • Targeted drug release intervened medical appliance and preparation method thereof

Examples

Experimental program
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Effect test

Example Embodiment

[0033] Example 1: A targeted drug release interventional medical device and its preparation method

[0034] The interventional medical device used is a coronary balloon dilatation catheter. Dissolve 100 mg of paclitaxel, 30 mg of polylactic acid, and 5 mg of polymethyl methacrylate in 2 ml of a solution of acetone, formic acid and vitamin E (volume ratio of acetone: formic acid: vitamin E = 8:1:1). After 10 minutes, a uniformly dispersed drug coating stock solution was obtained. Spray the above solution on the surface of a balloon with a size of 3.0×20mm, so that the drug loading can reach 3μg / mm 2 Left and right, dry and fold to get the drug balloon, attached figure 1 The SEM picture of the surface of the drug coating before folding. From the figure, we can see that the surface of the balloon is flat, without cracks, and no fragments. figure 2 This is the SEM picture of the drug coating surface after folding. From the figure, we can see that the coating is not missing, fragmen...

Example Embodiment

[0035] Example 2: A targeted drug release interventional medical device and its preparation method

[0036] The interventional medical device used is a peripheral vascular balloon dilatation catheter. Dissolve 200 mg of paclitaxel, 50 mg of chitin, and 18 mg of polybutyl methacrylate in 10 ml of a solution of ethanol, acetic acid and vitamin E (volume ratio of ethanol: acetic acid: vitamin E = 7: 2: 1), ultrasound 10min, form a uniformly dispersed drug coating stock solution. Dip coating the above solution on the surface of the balloon with a size of 4.0x100mm, so that the drug loading can reach 2μg / mm 2 Left and right, dry and fold to obtain the drug balloon.

Example Embodiment

[0037] Embodiment 3: A targeted drug release interventional medical device and its preparation method

[0038] The interventional medical device used is a urethra dilatation stent. Dissolve 400mg of pracamycin, 700mg of iodixanol, and 400mg of polyisobutyl methacrylate in 2ml of glycerol, acetone and butylated hydroxyanisole solution (the volume ratio is glycerol: acetone : Butylated hydroxyanisole=3:6:1) in the ultrasonic for 10min to form a uniformly dispersed drug coating stock solution. Apply the above solution to the surface of the biliary dilatation stent to achieve a drug loading of 9μg / mm 2 Left and right, dry, and get the drug slow release urethral dilatation stent.

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Abstract

The invention provides a targeted drug release intervened medical appliance and a preparation method thereof. The medical appliance is characterized by comprising an intervening medical appliance and a sustained-release drug coating, wherein the sustained-release drug coating is applied to the surface of the intervening medical appliance. The preparation method comprises a step of applying drugs to the intervening medical appliance to form the targeted drug release intervened medical appliance, wherein the sustained-release drug coating consists of a medicinal material, a medicinal carrier material, antioxidant and adhesive, and the drug application to the intervening medical appliance sequentially comprises the following steps: (1) preparing the sustained-release drug coating; (2) applying the sustained-release drug coating; (3) drying. According to the targeted drug release intervened medical appliance, the binding strength between the sustained-release drug coating and the surface of the intervening medical appliance is high, the medicinal material is prevented from being lost in the subsequent processing process, and the targeted drug release intervened medical appliance has a good drug treatment effect.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a device for intracavity therapy with an integrated structural design capable of targeted and fixed-point administration and slow release of therapeutic drugs in targeted lesion areas and a preparation method thereof. Background technique [0002] With the wide application of drug sustained-release stent systems and the continuous development of new technologies, the research on drug sustained-release stent systems has become more in-depth. During the operation, it was found that when the stent is implanted in the blood vessel, due to the expanded support of the metal or non-metallic stent, the inner wall of the blood vessel will inevitably be scratched, thereby causing damage. After surgery, patients need to take anticoagulant drugs to prevent blood clots from forming. Compared with bare stents without drug coating, vascular endothelial cells can heal automatically within 30 days...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/16A61L29/08A61L29/16
Inventor 陈毅生胡铁锋张秀丽
Owner 上海赢生医疗科技有限公司
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