130 results about "Drug application" patented technology

The invention provides an asymmetric drug interaction prediction method based on a diffusion diagram attention network, and relates to the technical field of drug interaction prediction.The method comprises the steps that a directed graph network is constructed by using chemical structure features of drug molecules, and features are extracted from drug applying and receiving perspectives through a two-way diagram attention network; therefore, the asymmetry between the drugs is effectively represented. Furthermore, a diffusion model is introduced to carry out noise injection and de-noising processing on a graph structure, so that the adaptability of the model to sparse data and the robustness of feature extraction are remarkably enhanced. Finally, multi-modal features are fused through a deep neural network, and high-precision prediction of drug interaction is realized. Compared with the prior art, the method has the advantages that the prediction accuracy exceeds that of the prior art, the dependence on labeled data is greatly reduced, the feasibility and generalization ability of the model in practical application are greatly improved, and a new technical path is provided for safety evaluation and precise medical research of drug combination therapy.

The invention discloses a skin anti-infection medicine applying device, and relates to the field of medical smearing medicine applying appliances, the skin anti-infection medicine applying device comprises a shell, the shell is provided with a handle, the handle is provided with an opening, and the handle is rotatably connected with a driving part capable of covering the opening. The roller assembly comprises a pair of roller frames which are arranged in parallel, each roller frame is provided with a U-shaped groove used for being rotationally connected with a smearing roller, the two sides of each U-shaped groove are further oppositely connected with limiting rods in a sliding mode, and the limiting rods are connected to the roller frames through springs. Ointment is extruded out through the extrusion assembly and conveyed and smeared to the infected part of a patient, it is reduced that limbs of the patient make contact with ointment smearing, and therefore infection is reduced. Meanwhile, the medicine is automatically extruded and smeared, so that the uniformity of medicine smearing is improved.

The present invention pertains to the technical field of drug application and particularly relates to clinical use of a KRAS G12D inhibitor. The inhibitor can be clinically used to effectively treat patients with advanced solid tumors carrying the KRAS G12D mutation and can produce beneficial effects.

The invention relates to the technical field of medicine smearing, and discloses a medicine uniform smearing device for the traditional Chinese medicine dermatology department, the medicine uniform smearing device comprises a butt joint adjusting mechanism, the bottom of the butt joint adjusting mechanism is provided with an adjusting type medicine smearing mechanism, the top of the butt joint adjusting mechanism is provided with a medicine storage mechanism, and the medicine storage mechanism is internally provided with a pushing, injecting and air drying mechanism; and a detachable smearing mechanism is arranged on the surface of the medicine storage mechanism. According to the medicine uniform smearing device for the traditional Chinese medicine dermatology department, through the arrangement of a butt joint adjusting mechanism, an adjusting type medicine smearing mechanism, a medicine storage mechanism, a pushing injection air drying mechanism and a detachable smearing mechanism, the adjusting type medicine smearing mechanism can be converted through the butt joint adjusting mechanism in the using process, and the smearing mode can be conveniently converted according to whether hair exists on the affected part of a patient or not; and isolation can be added according to whether cross infection needs to be avoided or not, so that the pertinence during smearing is improved.

The invention discloses application of mangiferin in preparation of a protective agent for testicular sertoli cells and preparation of a medicine for treating male infertility diseases, and relates to the technical field of medicine application. Wherein the mangiferin can play a role in protecting the sertoli cells, and the protection role is reflected in ways of improving the cell viability of the sertoli cells, inhibiting the apoptosis of the sertoli cells, inhibiting the oxidative stress of the sertoli cells, inhibiting the inflammatory response of the sertoli cells and the like; meanwhile, mangiferin can be used for treating male infertility diseases in ways of relieving weight loss, repairing testis, improving endocrine system functions, inhibiting oxidative stress of testis tissues, inhibiting inflammatory response of the testis tissues and the like. Wherein the mangiferin can inhibit the inflammatory reaction mainly by inhibiting the activation of NLRP3 inflammasome to inhibit the NLRP3 pathway, so that the inflammation and even pyroptosis of testicular sertoli cells are remarkably reduced to improve spermatogenesis, and the male infertility disease is well treated.

The invention provides a combined medicine recommendation method based on multi-modal alignment. A core module of the recommendation method comprises a cloth perception multi-modal medicine alignment module, a time sequence multi-view patient aggregation module and a combined medicine recommendation module. According to the recommendation method, electronic health records EHRs serve as a data source, multi-modal information matched with physical signs of a patient and medicine application characteristics is obtained, effective alignment and fusion are conducted on the multi-modal information through the core module, and suggestion data matched with the multi-modal information and composed of multiple medicines are generated. A DDI loss function and a dynamic weighting strategy are introduced to process conflicts among different drugs in the generated suggestion data so as to output safe suggestion data, and it is avoided that conflicting drugs are recommended in the suggestion data; according to the method, personalized, high-safety, scientific and reasonable drug combination suggestions can be provided.

The invention discloses a sorafenib-paclitaxel combined prodrug as well as a preparation method and application thereof, and relates to the field of chemical pharmacy, a prodrug strategy is utilized, sorafenib and paclitaxel are covalently linked through a disulfide bond, and an S-PTX drug is successfully prepared. The drug can be self-assembled to form stable nanoparticles in an aqueous solution system containing 1% of absolute ethyl alcohol and 1% of polyoxyethylated castor oil by means of hydrophobic interaction, Van der Waals force and the special chemical properties of disulfide bonds. According to the invention, the drug delivery is carried out without any additional carrier, so that the problem of carrier toxicity when the carrier is introduced into the traditional nano delivery system is avoided, the safety of the drug in in-vivo application is greatly improved, and a solid and reliable foundation is provided for subsequent clinical treatment. The sorafenib-paclitaxel combined prodrug S-PTX prepared by the invention effectively solves the problem of drug resistance caused by medication of a single drug.

The invention discloses a wart excision device which combines wart excision and medicine spraying functions, can immediately perform medicine treatment after wart excision, effectively promotes wound healing, reduces infection risk, reduces the possibility of wart recurrence, and improves thoroughness and durability of treatment. And secondly, the operation design of the device is extremely humanized, and the patient can operate the device at home without going to a hospital or a professional medical institution, so that the time and economic cost are greatly saved, and meanwhile, the psychological burden and anxiety mood of the patient caused by seeing a doctor are also relieved. The design of the adjustable blade assembly and the straight blade is adopted by the device, the cutting mode can be flexibly adjusted according to the shape and size of warts, accurate excision is achieved, damage to surrounding normal skin is reduced to the maximum extent, and therefore the pain feeling is reduced, and the size of wounds is reduced. In addition, the medicine applying assembly of the device can accurately spray medicine to the wound surface, pain is further relieved, and rapid healing of the wound is promoted.

The invention discloses a method for predicting peripheral neurotoxicity induced by treatment of colorectal cancer through oxaliplatin, and relates to the technical field of drug application, and the method comprises the following steps: obtaining pre-drug patient information before treatment of a patient with oxaliplatin and clinical feature data after use; processing and feature analysis are carried out based on pre-drug patient information and clinical feature data, and a core feature data set related to neurotoxin is determined; and based on the core feature data set, predicting the oxaliplatin-induced peripheral neurotoxicity of the patient by adopting a pre-trained gradient boosting decision tree model, and outputting a prediction risk result. According to the method, the occurrence risk of peripheral neurotoxicity can be accurately predicted according to clinical indexes so as to guide clinical accurate medication.

The invention discloses an antibody as well as a preparation method and application thereof. The antibody has good binding activity with OXA-23 type carbapenem enzyme, and can reduce the carbapenem drug resistance level of the acinetobacter baumannii, so that the clinical use concentration of meropenem is reduced, and the treatment effect of meropenem on the acinetobacter baumannii is improved. In addition, the antibody disclosed by the invention can also inhibit OXA-23 protein secreted by bacteria, prevent the bacteria from hydrolyzing carbapenem antibiotics, increase the concentration of antibiotics in a medication part, and facilitate the removal of mixed infection with acinetobacter baumannii. The invention provides a new strategy for treating acinetobacter baumannii infection, and the application prospect is wide.

The present application belongs to the technical field of hair loss treatment, and particularly relates to a phototherapy and drug synergistic intervention system for androgenetic alopecia of human scalp. In the system, the drug is angelica extract with a concentration of 0.1-500 ug / mL; the phototherapy light source is a red light LED light source with a wavelength of 600-700 nm; the light irradiance is 2-100 mW / cm 2 ; the light dose is 2-20 J / cm 2 ; the irradiation mode is steady light or pulsed light; and the synergistic intervention mode is that the phototherapy and the drug application are performed synchronously or the phototherapy is performed within 0.5-2 hours after the drug application. Experiments show that the light-drug combined intervention significantly improves cell viability, ATP level, migration ability, IGF1 and VEGF secretion, reduces ROS and MDA levels, inhibits Caspase-3 activity, regulates BCL2 / BAX expression, activates Wnt, Hh and PI3K pathways, and inhibits BMP and TGF-beta pathways. The present application provides a treatment scheme with clear timing and standardization, and realizes safe, non-invasive and efficient hair loss treatment.

The invention belongs to the technical field of biotechnology, and particularly relates to application of an exosome MZF1 protein marker in a liver cirrhosis diagnosis / treatment medicine or reagent, a kit and a detection method. The invention provides an application of an exosome MZF1 protein marker in a liver cirrhosis diagnosis / treatment medicine or reagent, a kit for liver cirrhosis diagnosis / treatment and a detection method of a serum exosome MZF1 protein. The exosome MZF1 protein is used as a marker, a valuable reagent or drug application prospect is provided for early diagnosis and treatment of liver cirrhosis, and help is provided for analysis of more serum exosome proteins applied to liver cirrhosis markers.

The application discloses a method for calculating the area of pesticide application. The method comprises the following steps: obtaining the motion trajectory of a pesticide application device, and intercepting a third trajectory located in a first area to be applied with pesticide; obtaining a radiation range according to the third trajectory and the pesticide application range, and performing color processing; calculating the area after color processing to obtain the pesticide application area, and judging the pesticide application condition in combination with a target area. In addition, after the pesticide application is completed, a trajectory point is randomly selected as a detection position, and a corresponding plant image is required to be uploaded for verification. The application solves the area calculation problem of irregular areas and overlapping spraying through a color algorithm, and realizes precise quantitative evaluation and anti-fraud supervision of the pesticide application quality in combination with a random inspection mechanism.

The invention belongs to the technical field of immunology, and discloses an anti-human CD19 receptor single-domain antibody, and the amino acid sequence of the single-domain antibody is as shown in SEQ ID No.1. The antibody has good reaction activity with human CD19, can be used for detecting or diagnosing CD19 and treating related diseases with abnormal CD19 expression, and has wide application prospects in the fields of drug application, clinical detection and diagnosis and the like.

The invention discloses a medical cosmetology scar removing device in the technical field of medical cosmetology. The medical cosmetology scar removing device comprises a base and a supporting frame, a placing assembly is installed at the top end of the base, a transmission assembly is installed in the supporting frame, a rolling assembly is installed at the lower end of the transmission assembly, and a driving assembly is arranged in the supporting frame; the transmission assembly comprises a driving shaft fixedly connected with the driving assembly, one end, away from the driving assembly, of the driving shaft is coaxially provided with a guide rotating body, the surface of the guide rotating body is provided with a spiral guide rail with gradually-changed screw pitch, the spiral guide rail is in sliding fit with a guide wheel, the guide wheel is rotationally connected with a lifting rod, and the middle of the lifting rod is annularly sleeved with a sliding block in sliding fit with the lifting rod. One side of the sliding block is horizontally and fixedly connected with a moving rod; the guide rotating body is a cylinder, and the cylinder surface is a streamline curved surface. According to the medicine applying device, through auxiliary cooperation of the guide rotating body, the spiral guide rail, the sliding block and the moving rod, the movement track of the rolling assembly better fits the curved movement of the arm, and the possibility that the skin of the arm is injured during medicine applying is reduced.

This invention discloses a preparation process for a homogeneous immunomodulatory polysaccharide from *Gynostemma pentaphyllum* and its application in the preparation of anti-melanoma drugs and immunomodulators, relating to the field of pharmaceutical manufacturing technology. The preparation process includes four steps: compound enzyme-ultrasound synergistic extraction, fractional alcohol precipitation to remove proteins, DEAE-52 ion exchange column chromatography, and Sephacryl S-400 gel permeation chromatography purification. The resulting homogeneous polysaccharide (GOP-3) has a weight-average molecular weight of 12±1 kDa and is composed of mannose, glucose, and galactose in a specific ratio. The GOP-3 of this invention has a weight-average molecular weight (Mw) of 12.8 kDa, a dispersion (Mw / Mn) < 1.2, a uronic acid content of 23.5%, a well-defined structure, and is suitable for drug application. Furthermore, GOP-3 can significantly promote the secretion of IL-12 by dendritic cells and induce the differentiation of naive T cells into Th1 cells. Simultaneously, compared with a full-dose PD-1 monoclonal antibody, the combination of GOP-3 and a half-dose monoclonal antibody not only reduces the risk of immune-mediated pneumonia caused by antibody drugs but also increases the tumor inhibition rate by more than 40%.

The application relates to application of C-methylated high isoflavone compounds in preparation of antitumor drugs and belongs to the technical field of drug application. In order to solve the problem that the existing antitumor activity is not much reported, the application of C-methylated high isoflavone compounds in preparation of antitumor drugs is provided, the C-methylated high isoflavone compounds are selected from compounds shown in the following formula 1 or formula 2: the C-methylated high isoflavone compounds or pharmaceutically acceptable salts thereof are used as active ingredients for preparation of antitumor drugs for preventing and / or treating adrenal pheochromocytoma (PC-12) and / or human brain astrocytoma (U-87MG). The C-methylated high isoflavone compounds have the advantages of high activity and high inhibition capacity, can be extracted from polygonatum sibiricum and have good drug safety.

The invention relates to the technical field of biological medicines, and particularly discloses a high-grade serous ovarian cancer (HGSOC) treatment strategy based on ANXA6 protein detection and regulation. The invention provides a method for evaluating the sensitivity of a patient to cisplatin chemotherapy by detecting the expression level of ANXA6 protein or a specific modification site thereof, and a composition comprising inhibiting the function of ANXA6 or combining with cisplatin. In addition, the invention also relates to a medicine application for enhancing the chemotherapy effect by regulating the activity of ANXA6 related modifying enzyme.

The utility model relates to the technical field of medical instruments, in particular to a medicine applying device for premature infant iatrogenic skin injury. Comprising a material guide pipe, a chassis and a disc, the bottom of the material guiding pipe is fixedly connected with a base plate, at least one through hole is formed in the base plate, the through holes are evenly distributed in the circumferential direction of the base plate, the base plate is connected with a disc in an inserted mode through the through holes, a flowing hole is formed in the middle of the disc, and the disc is communicated with the material guiding pipe through the flowing hole. Through the arrangement of the material guide pipe and the circular sponge, liquid medicine is injected into the circular sponge from the material guide pipe, the circular sponge is in contact with the skin injury position of the premature infant after being stained with the liquid medicine, and the skin injury position of the premature infant can be massaged while the liquid medicine is smeared through the circular sponge; the skin injury part of the premature infant can be massaged before liquid medicine is smeared, different nursing tools do not need to be replaced, and the medicine smearing efficiency is improved.

The invention relates to the technical field of medicines, in particular to a pharmaceutical composition of mupirocin ointment and a preparation method of the pharmaceutical composition. The invention aims to solve the problem that the existing mupirocin ointment only pays attention to stability and neglects skin barrier repair, so that treatment and healing are disjointed. The composition comprises mupirocin, chitosan and the like, and is characterized in that a multiphase microstructure system is constructed, glyceryl monostearate provides hydrophobic protection for mupirocin, and lactic acid activates chitosan. The preparation method adopts three-stage temperature control synchronous homogeneous curing. The invention solves or at least alleviates the inherent defect that in the prior art, a mupirocin ointment preparation only focuses on the chemical stability of a medicine but neglects the biological requirement of skin barrier repair of a medication part, and provides a pharmaceutical composition of a mupirocin ointment and a preparation method thereof.

The invention relates to an aquacide microsphere preparation and a preparation method thereof, aquacide is entrapped in a polylactic acid-glycolic acid copolymer carrier through a W / O / W type re-emulsification-solvent evaporation method, the microsphere preparation is prepared, slow and continuous release of drugs can be realized, the lasting period is prolonged, the drug application frequency is reduced, and the drug wastage rate and the environmental risk are reduced; meanwhile, the pesticide is in a solid state, is suitable for long-distance transportation, can be redissolved before being used, and has important practical application and commercial values.

The application discloses a kind of saving type synchronous oiling and dosing methods for drug application unmanned aerial vehicle, including two feeding nozzles arranged on the material adding unmanned aerial vehicle and drug application oil tank and drug application tank arranged on the drug application unmanned aerial vehicle;The structure of drug application oil tank and drug application tank is same, and it includes box, leakage-proof sealing film, one-way pressure door and liquid leakage collection box;Feeding nozzle includes outer tube and inner tube arranged in outer tube, and the end of outer tube is inserted into the through hole of liquid leakage collection box after passing through the flow channel, and the open end of inner tube faces automatic telescopic structure, and automatic telescopic structure drives automatic support mechanism to extend into the inner side of inner tube, and after electric support mechanism drives the support claw of itself to open, it is supported on the inner wall of inner tube;The application solves the problem that the existing drug application unmanned aerial vehicle repeatedly lifts to add oil and medicine, resulting in low work efficiency, and the problem of supply waste and environmental pollution caused by material leakage when the material adding unmanned aerial vehicle supplies the drug application unmanned aerial vehicle in the air.

Application of a central polypeptide angiotensin-(5-7) in the preparation of a drug. The present invention demonstrates that Ang-(5-7) in the RVLM of WKY rats can enhance sympathetic output and increase blood pressure, and part of Ang-(5-7) acts on the AT1 receptor to participate in the central regulation of blood pressure. Further exploring the mechanism of action of Ang-(5-7) in the sympathetic center, it is found that Ang-(5-7) in the RVLM of WKY rats can enhance sympathetic output and increase blood pressure through the oxidative stress pathway, while targeting and interfering with the expression of DPP3 in the RVLM endogenously reduces Ang-(5-7) under the pathological state of hypertension, improves oxidative stress, and reduces the blood pressure of SHR rats. The research of the present invention shows that Ang-(5-7) enhances sympathetic output and increases blood pressure through the oxidative stress pathway and participates in the central regulation of the cardiovascular activities of patients.

The invention discloses a novel intelligent device and method for controlling movement observation, thrombus dredging and drug application of a vascular interventional object through a high-intensity magnetic field, and relates to the technical field of intelligent medical treatment. Comprising a movable module, electromagnetic driving equipment, a real-time detection module, a skin feature point recorder and a nuclear magnetic resonance imager, the movable module is used for moving in the blood vessel and completing a specific task; the electromagnetic driving equipment is used for forming a local strong magnetic field by cutting magnetic induction lines so as to drive the movable module to freely move in the blood vessel; the real-time detection module is arranged in the electromagnetic driving equipment and is used for monitoring the position information of the movable module; the skin feature point recorder is used for recording human body key positioning points; and the nuclear magnetic resonance imager is used for confirming a lesion target point X-OUT and an intervention point X-IN of the movable module. The problems that an existing micro-robot is limited in movement in the blood vessel, the control precision is insufficient, and the surgical risk is high are solved.

The invention discloses a periodontal treatment local medicine application device, and relates to the technical field of periodontal treatment, and the periodontal treatment local medicine application device comprises a medicine delivery unit which comprises a medicine bin, a feeding assembly and a medicine application assembly; the protection unit comprises a tooth support assembly and an adjusting assembly. The oral cavity of a patient can be supported, secondary damage caused by the fact that the patient closes the oral cavity due to stress is prevented, and the adjusting assembly allows the position and the angle of the tooth support to be flexibly adjusted according to the unique oral cavity structure and the treatment requirement of each patient so as to optimize the comfort and the effect in the treatment process. It can be guaranteed that the medicine can cover the whole affected part of the oral cavity without missing any part, and meanwhile the risks of excessive use of the medicine and cross infection are avoided.

The invention relates to a novel method for reducing drug-induced cell death, and belongs to the technical field of biological medicines. LP-Rh2 in the form of lipidosome is prepared by providing a skeleton structure by lipidosome and taking ginsenoside Rh2 as a functional component, and after LP-Rh2 and other drugs are jointly added into a cell culture system, the drug-induced cytotoxicity can be inhibited in various scenes, the cell viability is improved, and the drug-induced cytotoxicity can be inhibited. Therefore, the action mechanism of other candidate drugs with cytotoxicity can be better matched and researched in scientific research application, and potential safety risks possibly brought by drugs, especially vaccine adjuvants, can be reduced in drug application.

The invention discloses a compound serving as an AKR1C3 (aldoketoreductase 1C3) inhibitor as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The compound has a structure shown in a formula I or a pharmaceutically acceptable salt thereof; wherein when R1 is carboxyl, A is a nitrogen-containing saturated aromatic ring, and B is an unsaturated aromatic ring or an unsaturated heterocyclic ring; when R2 is carboxyl, B is an unsaturated aromatic ring, and A is a condensed ring containing a nitrogen-containing saturated aromatic ring. The piperidinecarboxylic acid compound or benzoic acid compound and the pharmaceutically acceptable salt thereof provided by the invention can selectively inhibit the activity of AKR1C3, have a remarkable inhibition effect, achieve the effect of preventing and treating prostatic cancer through a final step of inhibiting the generation of androgen in tumor cells, can be prepared into a medicine for treating AKR1C3 related diseases, and have a wide application prospect. Particularly, the compound is applied to preparation of a medicine for treating prostatic cancer. Formula I.

The application relates to a dihydropyridine small-molecule compound and a preparation method and application thereof in preparing a drug for treating neuroblastoma, and belongs to the technical field of drug preparation. The application discloses a dihydropyridine small-molecule compound, a structural formula of which is as shown in the description, which can be used for preparing a drug for treating neuroblastoma with high ALDH18A1 expression, can effectively solve the problems of poor water solubility of YG1702, low inhibition rate of neuroblastoma and other drug application problems, and has a good application prospect.

The invention relates to the technical field of veterinary drugs, and particularly discloses a long-acting tick-repelling compound preparation which comprises the following components: a component A, a component B, a component C and a component D, the component A comprises the following components in percentage by weight: 0.3-0.7% of fipronil, 1.0-1.5% of permethrin, 25-35% of silicon dioxide and 0.05-0.15% of iron oxide red; the component B comprises the following components in percentage by weight: 12%-18% of polyacrylate colloid (medicinal grade), 4%-6% of castor oil polyoxyethylene ether, 1.5%-2.5% of azone and 1.5%-2.5% of absolute ethyl alcohol; wherein the mixing weight ratio of the component A to the component B is (1: 1.5)-(1: 2.5); through the synergistic effect of silica micropore adsorption and the polyacrylate colloid sustained-release film, the sustained release of the drug for 180 + / -5 days is realized, the drug application frequency is greatly reduced, the safety is remarkably improved, and the animal licking risk is reduced by adding menthol.

The invention belongs to the technical field of agricultural equipment, and particularly relates to a pomegranate forest nursery stock pest control-based pesticide smearing device, which comprises a vehicle body, a support frame, a sliding rod and a storage tank, the two lifting mechanisms are connected to the sliding rod in a sliding mode; the two smearing mechanisms are fixedly mounted on the two lifting mechanisms correspondingly; the stirring mechanism is arranged in the storage tank; the linkage mechanism is arranged on the vehicle body; the liquid conveying mechanism is arranged between the smearing mechanism and the storage tank; wherein the smearing mechanism comprises an outer ring and an inner ring, a smearing part is fixedly mounted on the top surface of the inner ring, a driving part is fixedly mounted on the bottom surface of the outer ring, a locking part is arranged on the outer ring, and a scraping plate is further fixedly connected to the outer ring. Through uniform smearing, continuous stirring and convenient maintenance design, the pomegranate forest nursery stock pest control efficiency and quality are remarkably improved.