185 results about "Drug application" patented technology

The invention discloses a multi-input model compensation plant protection robot pesticide application control system and control method, and belongs to the technical field of agricultural plant protection. The system comprises an upper computer input system, a lower computer controller and a pesticide application system; the upper computer input system is based on an image processing unit of an AI edge computing platform, performs target identification by using a deep learning model, and extracts key information of target crops or weeds in real time; the lower computer controller receives target information transmitted by the upper computer, adopts a dynamic front adjustment strategy of a spray boom virtual line, and dynamically controls an execution element according to the real-time traveling speed of a vehicle, sensor data of a pesticide application system and key information of target crops or weeds, so that accurate target pesticide spraying is realized; the pesticide applying system comprises a pesticide box, a plunger pump, a flow sensor, a pressure sensor, a switch valve, an electric ball valve, an overflow valve, a PWM proportional electromagnetic valve and a nozzle array. The pesticide applying precision is improved, the pesticide using amount is reduced, and the sustainability of agricultural production is improved.

The invention provides an asymmetric drug interaction prediction method based on a diffusion diagram attention network, and relates to the technical field of drug interaction prediction.The method comprises the steps that a directed graph network is constructed by using chemical structure features of drug molecules, and features are extracted from drug applying and receiving perspectives through a two-way diagram attention network; therefore, the asymmetry between the drugs is effectively represented. Furthermore, a diffusion model is introduced to carry out noise injection and de-noising processing on a graph structure, so that the adaptability of the model to sparse data and the robustness of feature extraction are remarkably enhanced. Finally, multi-modal features are fused through a deep neural network, and high-precision prediction of drug interaction is realized. Compared with the prior art, the method has the advantages that the prediction accuracy exceeds that of the prior art, the dependence on labeled data is greatly reduced, the feasibility and generalization ability of the model in practical application are greatly improved, and a new technical path is provided for safety evaluation and precise medical research of drug combination therapy.

Provided are an anti-BCMA single-domain antibody, and a preparation method therefor and the use thereof. Specifically, provided is a single-domain antibody having an amino acid sequence of SEQ ID No. 1. The single-domain antibody has high affinity, can thoroughly specifically target BCMA-positive cells, and can be applied to the detection of BCMA expression in bone marrow cells of MM patients. The single-domain antibody can be prepared into a specific antibody drug clinically used for preventing and treating BCMA-target-related diseases (such as multiple myeloma, B-cell acute lymphoblastic leukemia, non-Hodgkin's lymphoma and Hodgkin's lymphoma); or a BCMA protein detection kit, etc. The single-domain antibody has a stable structure, a small molecular size, is easily recombinantly expressed and has a low production cost, can be used alone or as a drug delivery system to carry relevant drugs, and has very wide prospects and important significance in fields such as drug application and clinical diagnosis.

The invention discloses a skin anti-infection medicine applying device, and relates to the field of medical smearing medicine applying appliances, the skin anti-infection medicine applying device comprises a shell, the shell is provided with a handle, the handle is provided with an opening, and the handle is rotatably connected with a driving part capable of covering the opening. The roller assembly comprises a pair of roller frames which are arranged in parallel, each roller frame is provided with a U-shaped groove used for being rotationally connected with a smearing roller, the two sides of each U-shaped groove are further oppositely connected with limiting rods in a sliding mode, and the limiting rods are connected to the roller frames through springs. Ointment is extruded out through the extrusion assembly and conveyed and smeared to the infected part of a patient, it is reduced that limbs of the patient make contact with ointment smearing, and therefore infection is reduced. Meanwhile, the medicine is automatically extruded and smeared, so that the uniformity of medicine smearing is improved.

The invention provides a medicine composition containing vinloxacin hydrochloride. The medicine composition comprises a quick-release pellet and a sustained-release pellet. The pharmaceutical composition provided by the invention has the advantages of good stability, capability of simultaneously meeting the specific requirement on in-vitro dissolution of the viloxin hydrochloride, small variety and dosage of auxiliary materials, higher safety and suitability for preparation of a preparation. And the protective layer is sprayed on the outer surface of the sustained-release layer, so that the advantages of weakening the electrostatic interaction of the pellets and preventing the particles from caking in the aging process are further achieved. In addition, the invention also provides a preparation method of the pharmaceutical composition, and the method has the advantages of high drug application rate, less fine powder, no filter bag and spray gun head blockage phenomenon, and suitableness for industrial production and application.

The present invention pertains to the technical field of drug application and particularly relates to clinical use of a KRAS G12D inhibitor. The inhibitor can be clinically used to effectively treat patients with advanced solid tumors carrying the KRAS G12D mutation and can produce beneficial effects.

The invention relates to the technical field of medicine smearing, and discloses a medicine uniform smearing device for the traditional Chinese medicine dermatology department, the medicine uniform smearing device comprises a butt joint adjusting mechanism, the bottom of the butt joint adjusting mechanism is provided with an adjusting type medicine smearing mechanism, the top of the butt joint adjusting mechanism is provided with a medicine storage mechanism, and the medicine storage mechanism is internally provided with a pushing, injecting and air drying mechanism; and a detachable smearing mechanism is arranged on the surface of the medicine storage mechanism. According to the medicine uniform smearing device for the traditional Chinese medicine dermatology department, through the arrangement of a butt joint adjusting mechanism, an adjusting type medicine smearing mechanism, a medicine storage mechanism, a pushing injection air drying mechanism and a detachable smearing mechanism, the adjusting type medicine smearing mechanism can be converted through the butt joint adjusting mechanism in the using process, and the smearing mode can be conveniently converted according to whether hair exists on the affected part of a patient or not; and isolation can be added according to whether cross infection needs to be avoided or not, so that the pertinence during smearing is improved.

The invention relates to a drug application of nardosinone in preventing or treating alopecia and promoting hair growth. The medicine for preventing or treating alopecia comprises nardosinone or pharmaceutically usable salts, esters or glycosides thereof. The nardosinone is used as a unique active component, 75% ethanol is adopted to prepare a solution with the concentration range of 1.0-3.0 mg / mL, the solution is externally applied to scalp, and the administration dosage range of the solution for preventing or treating alopecia of adults is 1-10 mL per day. The existing medicine for hair loss and alopecia is poor in treatment effect and has side effects. Research finds that nardosinone serving as an active component can achieve the application effect of preventing or treating alopecia and white hair by regulating and controlling the level of TGF beta family genes closely related to hair development and growth. The invention verifies that the active monomer nardosinone derived from rhizoma nardostachyos has the potential of preventing or treating the alopecia for the first time, the alopecia can be prevented or treated through skin administration of a certain dose of nardosinone, and a new method is provided for preventing or treating the alopecia.

The present invention relates to the technical field of medical devices, and discloses an integrated device for inspection, medication and sampling, comprising a handle, the top of the handle is fixedly connected to a shell, the bottom of the inner wall of the shell is fixedly connected to an inner tube, a top cover is installed on the top of the shell, a sampling cotton swab is plugged into the top of the top cover, a plurality of leakage holes are opened on the surface of the shell, the inner diameter of the shell is fixedly connected to a partition, and the bottom of the shell is rotatably connected to a matching plate. The integrated device for inspection, medication and sampling, by providing a medicine coating component, allows the medicine to be evenly applied to the surface of the shell, and then by placing the shell in the vagina, the medicine coated on the surface of the shell is evenly in contact with the inner wall of the vagina, thereby ensuring the uniformity of the medicine coating, improving the medication effect of the device, and being more conducive to the absorption and healing of the vagina by the medicine, and the shell and the inner tube are placed in the vagina, and sampling is performed by contacting the sampling cotton swab with the vagina, so that the medicine application and sampling are completed at the same time, thereby preventing secondary operation and friction damage to the patient's vagina.

The invention relates to the technical field of biological medicines, in particular to a polypeptide for regulating the activity of a GLUT4 receptor and a medicine application of the polypeptide, the polypeptide comprises SEQ. NO: 1: Asp-Pro-Gly-Leu-Thr (DPGLT), SEQ. NO: 2: His-Cys-Val-Arg-Asn (HCVRN), SEQ. NO: 3: Gly-Met-Ser-Lys-Phe (GMSKF), and SEQ. NO: 4: Tyr-Trp-Arg-His-Glu (YWRHE). The invention also relates to a preparation method of the polypeptide for regulating the activity of the GLUT4 receptor. Experimental results show that the novel polypeptide can effectively promote the transport and activity of GLUT4, improve blood sugar control and reduce the blood sugar level.

The invention discloses application of mangiferin in preparation of a protective agent for testicular sertoli cells and preparation of a medicine for treating male infertility diseases, and relates to the technical field of medicine application. Wherein the mangiferin can play a role in protecting the sertoli cells, and the protection role is reflected in ways of improving the cell viability of the sertoli cells, inhibiting the apoptosis of the sertoli cells, inhibiting the oxidative stress of the sertoli cells, inhibiting the inflammatory response of the sertoli cells and the like; meanwhile, mangiferin can be used for treating male infertility diseases in ways of relieving weight loss, repairing testis, improving endocrine system functions, inhibiting oxidative stress of testis tissues, inhibiting inflammatory response of the testis tissues and the like. Wherein the mangiferin can inhibit the inflammatory reaction mainly by inhibiting the activation of NLRP3 inflammasome to inhibit the NLRP3 pathway, so that the inflammation and even pyroptosis of testicular sertoli cells are remarkably reduced to improve spermatogenesis, and the male infertility disease is well treated.

The invention provides a combined medicine recommendation method based on multi-modal alignment. A core module of the recommendation method comprises a cloth perception multi-modal medicine alignment module, a time sequence multi-view patient aggregation module and a combined medicine recommendation module. According to the recommendation method, electronic health records EHRs serve as a data source, multi-modal information matched with physical signs of a patient and medicine application characteristics is obtained, effective alignment and fusion are conducted on the multi-modal information through the core module, and suggestion data matched with the multi-modal information and composed of multiple medicines are generated. A DDI loss function and a dynamic weighting strategy are introduced to process conflicts among different drugs in the generated suggestion data so as to output safe suggestion data, and it is avoided that conflicting drugs are recommended in the suggestion data; according to the method, personalized, high-safety, scientific and reasonable drug combination suggestions can be provided.

The utility model provides precise pesticide application full-automatic equipment for vegetable insect pests. The precise pesticide application full-automatic equipment comprises a box body, and strip-shaped holes extending in the first horizontal direction are formed in the side wall of the box body; a liquid storage barrel is arranged in the box body and is communicated with the pesticide spraying pipe; the pesticide spraying pipe is provided with a branch pipe which extends out of the box body from the strip-shaped hole in the second horizontal direction, and the free end of the branch pipe is provided with an atomizing nozzle. A first driving assembly is arranged in the box body, the driving end of the first driving assembly is connected with a second driving assembly, the driving end of the second driving assembly is connected with a pesticide spraying pipe, and a driving device is further arranged at the bottom of the box body; the equipment is started, and the atomizing nozzle sprays liquid medicine; the driving assembly adjusts the positions of the atomizing nozzles in the first horizontal direction and the second horizontal direction, so that the atomizing nozzles are kept to spray pesticide directly facing crops; by arranging the first driving assembly and the second driving assembly, the pesticide spraying pipe alternately moves in the second horizontal direction and the first horizontal direction, precise fixed-point pesticide spraying on crops is achieved, and the problems that when pesticide liquid is sprayed, the environment is polluted, and the soil quality is affected are solved.

The invention belongs to the technical field of quality control, and relates to a method for on-line monitoring of the drug application rate of a pellet coating by combining near infrared spectroscopy with real-time weighing. The method comprises the following steps: (a) providing an active pharmaceutical ingredient (API) content model, detecting a real-time near infrared spectrum in a pellet coating process in real time, and predicting the real-time API content according to the real-time near infrared spectrum by adopting the API content model; (b) the coating liquid is weighed in real time in the pellet coating process, the real-time coating liquid weight is obtained, the obtaining time point of the real-time coating liquid weight is the same as the obtaining time point of the real-time near infrared spectrum, and the real-time total coating weight is obtained according to the real-time coating liquid weight technology; and (c) calculating the real-time pellet coating drug application rate according to the real-time API content and the real-time total coating weight. According to the invention, the drug application rate of the pellets can be accurately monitored in real time in the coating process.

The invention discloses a sorafenib-paclitaxel combined prodrug as well as a preparation method and application thereof, and relates to the field of chemical pharmacy, a prodrug strategy is utilized, sorafenib and paclitaxel are covalently linked through a disulfide bond, and an S-PTX drug is successfully prepared. The drug can be self-assembled to form stable nanoparticles in an aqueous solution system containing 1% of absolute ethyl alcohol and 1% of polyoxyethylated castor oil by means of hydrophobic interaction, Van der Waals force and the special chemical properties of disulfide bonds. According to the invention, the drug delivery is carried out without any additional carrier, so that the problem of carrier toxicity when the carrier is introduced into the traditional nano delivery system is avoided, the safety of the drug in in-vivo application is greatly improved, and a solid and reliable foundation is provided for subsequent clinical treatment. The sorafenib-paclitaxel combined prodrug S-PTX prepared by the invention effectively solves the problem of drug resistance caused by medication of a single drug.

The invention provides an intelligent copper release nano preparation triggered by a magnetic effect as well as a preparation method and drug application thereof. The preparation is ES (at) Fe3O4 (at) SiO2-Cu; the preparation method comprises the following steps: adding FeCl3. 6h2O and CH3COONa into ethylene glycol, and carrying out hydrothermal reaction, washing and magnetic separation; dispersing the ferric oxide magnetic fluid in ammonia water for ultrasonic treatment, adding an ethanol solution containing 20% of tetraethyl silicate and a copper nitrate mixed solution for continuous reaction, washing with ethanol water, performing magnetic separation, dispersing the Fe3O4-coated SiO2-Cu fluid in an ammonium nitrate isopropanol solution, adding isopropanol water for ultrasonic treatment after magnetic separation, washing with ethanol water, replacing water with pure ethanol, and performing vacuum drying to obtain Fe3O4-coated SiO2-Cu; dispersing the mixture and ES in water, and carrying out violent ultrasonic oscillation; and dialyzing the bag overnight, and collecting to obtain ES (at) Fe3O4 (at) SiO2-Cu. The device is high in penetration depth, suitable for deep tumor treatment and good in heating efficiency under an alternating magnetic field.

The invention discloses a wart excision device which combines wart excision and medicine spraying functions, can immediately perform medicine treatment after wart excision, effectively promotes wound healing, reduces infection risk, reduces the possibility of wart recurrence, and improves thoroughness and durability of treatment. And secondly, the operation design of the device is extremely humanized, and the patient can operate the device at home without going to a hospital or a professional medical institution, so that the time and economic cost are greatly saved, and meanwhile, the psychological burden and anxiety mood of the patient caused by seeing a doctor are also relieved. The design of the adjustable blade assembly and the straight blade is adopted by the device, the cutting mode can be flexibly adjusted according to the shape and size of warts, accurate excision is achieved, damage to surrounding normal skin is reduced to the maximum extent, and therefore the pain feeling is reduced, and the size of wounds is reduced. In addition, the medicine applying assembly of the device can accurately spray medicine to the wound surface, pain is further relieved, and rapid healing of the wound is promoted.

The invention discloses a method for predicting peripheral neurotoxicity induced by treatment of colorectal cancer through oxaliplatin, and relates to the technical field of drug application, and the method comprises the following steps: obtaining pre-drug patient information before treatment of a patient with oxaliplatin and clinical feature data after use; processing and feature analysis are carried out based on pre-drug patient information and clinical feature data, and a core feature data set related to neurotoxin is determined; and based on the core feature data set, predicting the oxaliplatin-induced peripheral neurotoxicity of the patient by adopting a pre-trained gradient boosting decision tree model, and outputting a prediction risk result. According to the method, the occurrence risk of peripheral neurotoxicity can be accurately predicted according to clinical indexes so as to guide clinical accurate medication.

The invention discloses an antibody as well as a preparation method and application thereof. The antibody has good binding activity with OXA-23 type carbapenem enzyme, and can reduce the carbapenem drug resistance level of the acinetobacter baumannii, so that the clinical use concentration of meropenem is reduced, and the treatment effect of meropenem on the acinetobacter baumannii is improved. In addition, the antibody disclosed by the invention can also inhibit OXA-23 protein secreted by bacteria, prevent the bacteria from hydrolyzing carbapenem antibiotics, increase the concentration of antibiotics in a medication part, and facilitate the removal of mixed infection with acinetobacter baumannii. The invention provides a new strategy for treating acinetobacter baumannii infection, and the application prospect is wide.

The present invention discloses a processing method for a drug use index statistical information system, and relates to the technical field of drug use index statistics. The main points of the technical solution are: the statistical attributes of the drug-based extension code are uniformly maintained in a background database, wherein the statistical attributes of the drug-based extension code in the background are respectively maintained by product name associated attributes, preparation specification code associated attributes, packaging specification code associated attributes, local extension code associated attributes, and production enterprise associated attributes according to attribute characteristics; the drug application end associates the drug prescription with the drug-based extension code; when performing statistics on each indicator, the local extension code attribute value associated with the prescription is obtained, and the corresponding indicator can be calculated after multiplying it by the cumulative number of prescriptions. The present invention can be used in the fields of hospital indicator statistics, government regulatory departments performing indicator statistics on all hospital prescriptions obtained, big data analysis, etc., and has the characteristics of rapid maintenance, consistent statistical results, simple procedures, etc.

The present application belongs to the technical field of hair loss treatment, and particularly relates to a phototherapy and drug synergistic intervention system for androgenetic alopecia of human scalp. In the system, the drug is angelica extract with a concentration of 0.1-500 ug / mL; the phototherapy light source is a red light LED light source with a wavelength of 600-700 nm; the light irradiance is 2-100 mW / cm 2 ; the light dose is 2-20 J / cm 2 ; the irradiation mode is steady light or pulsed light; and the synergistic intervention mode is that the phototherapy and the drug application are performed synchronously or the phototherapy is performed within 0.5-2 hours after the drug application. Experiments show that the light-drug combined intervention significantly improves cell viability, ATP level, migration ability, IGF1 and VEGF secretion, reduces ROS and MDA levels, inhibits Caspase-3 activity, regulates BCL2 / BAX expression, activates Wnt, Hh and PI3K pathways, and inhibits BMP and TGF-beta pathways. The present application provides a treatment scheme with clear timing and standardization, and realizes safe, non-invasive and efficient hair loss treatment.

The present invention relates to the biological field. Further, the present invention provides the use of iPSC induced differentiation into pancreatic progenitor cells combined with medication for the treatment of diabetes. Specifically, the present invention provides a monoclonal antibody that specifically inhibits the activity of BMP4, which can inhibit the differentiation of iPSC cells into common osteoblasts and adipocytes by inhibiting the activity of BMP4 protein, thereby promoting the transformation of iPSC into pancreatic progenitor cells and differentiation into islet-like cells. After the islet-like cells and ginsenoside Rb3 are combined to prepare a drug kit, the effect of lowering blood sugar can be significantly improved, and it has a good prospect for drug application.

The invention belongs to the technical field of biotechnology, and particularly relates to application of an exosome MZF1 protein marker in a liver cirrhosis diagnosis / treatment medicine or reagent, a kit and a detection method. The invention provides an application of an exosome MZF1 protein marker in a liver cirrhosis diagnosis / treatment medicine or reagent, a kit for liver cirrhosis diagnosis / treatment and a detection method of a serum exosome MZF1 protein. The exosome MZF1 protein is used as a marker, a valuable reagent or drug application prospect is provided for early diagnosis and treatment of liver cirrhosis, and help is provided for analysis of more serum exosome proteins applied to liver cirrhosis markers.

The application discloses a method for calculating the area of pesticide application. The method comprises the following steps: obtaining the motion trajectory of a pesticide application device, and intercepting a third trajectory located in a first area to be applied with pesticide; obtaining a radiation range according to the third trajectory and the pesticide application range, and performing color processing; calculating the area after color processing to obtain the pesticide application area, and judging the pesticide application condition in combination with a target area. In addition, after the pesticide application is completed, a trajectory point is randomly selected as a detection position, and a corresponding plant image is required to be uploaded for verification. The application solves the area calculation problem of irregular areas and overlapping spraying through a color algorithm, and realizes precise quantitative evaluation and anti-fraud supervision of the pesticide application quality in combination with a random inspection mechanism.

This invention relates to the field of pest control technology and discloses an electric sprayer for controlling borers of garden trees. The sprayer includes an electric pistol body, a liquid spray bottle assembly, and a sprayer assembly. The pistol body has a power button on its handle. A battery cavity is located at the bottom of the handle, housing a battery box containing a power battery. A cover is located at the rear of the pistol body, containing a circuit board electrically connected to the power button and the power battery. A trigger button is also located on the handle, and a trigger guard is fixedly mounted on the pistol body. This invention injects the pesticide solution into the larval tunnels via electric injection. When the borer larvae come into contact with the pesticide solution or by feeding on the fibrous tissue of the tree containing the pesticide, they are poisoned and die, thus effectively achieving pest control.

The invention belongs to the technical field of immunology, and discloses an anti-human CD19 receptor single-domain antibody, and the amino acid sequence of the single-domain antibody is as shown in SEQ ID No.1. The antibody has good reaction activity with human CD19, can be used for detecting or diagnosing CD19 and treating related diseases with abnormal CD19 expression, and has wide application prospects in the fields of drug application, clinical detection and diagnosis and the like.

The invention discloses a medical cosmetology scar removing device in the technical field of medical cosmetology. The medical cosmetology scar removing device comprises a base and a supporting frame, a placing assembly is installed at the top end of the base, a transmission assembly is installed in the supporting frame, a rolling assembly is installed at the lower end of the transmission assembly, and a driving assembly is arranged in the supporting frame; the transmission assembly comprises a driving shaft fixedly connected with the driving assembly, one end, away from the driving assembly, of the driving shaft is coaxially provided with a guide rotating body, the surface of the guide rotating body is provided with a spiral guide rail with gradually-changed screw pitch, the spiral guide rail is in sliding fit with a guide wheel, the guide wheel is rotationally connected with a lifting rod, and the middle of the lifting rod is annularly sleeved with a sliding block in sliding fit with the lifting rod. One side of the sliding block is horizontally and fixedly connected with a moving rod; the guide rotating body is a cylinder, and the cylinder surface is a streamline curved surface. According to the medicine applying device, through auxiliary cooperation of the guide rotating body, the spiral guide rail, the sliding block and the moving rod, the movement track of the rolling assembly better fits the curved movement of the arm, and the possibility that the skin of the arm is injured during medicine applying is reduced.

This invention discloses a preparation process for a homogeneous immunomodulatory polysaccharide from *Gynostemma pentaphyllum* and its application in the preparation of anti-melanoma drugs and immunomodulators, relating to the field of pharmaceutical manufacturing technology. The preparation process includes four steps: compound enzyme-ultrasound synergistic extraction, fractional alcohol precipitation to remove proteins, DEAE-52 ion exchange column chromatography, and Sephacryl S-400 gel permeation chromatography purification. The resulting homogeneous polysaccharide (GOP-3) has a weight-average molecular weight of 12±1 kDa and is composed of mannose, glucose, and galactose in a specific ratio. The GOP-3 of this invention has a weight-average molecular weight (Mw) of 12.8 kDa, a dispersion (Mw / Mn) < 1.2, a uronic acid content of 23.5%, a well-defined structure, and is suitable for drug application. Furthermore, GOP-3 can significantly promote the secretion of IL-12 by dendritic cells and induce the differentiation of naive T cells into Th1 cells. Simultaneously, compared with a full-dose PD-1 monoclonal antibody, the combination of GOP-3 and a half-dose monoclonal antibody not only reduces the risk of immune-mediated pneumonia caused by antibody drugs but also increases the tumor inhibition rate by more than 40%.

The application relates to application of C-methylated high isoflavone compounds in preparation of antitumor drugs and belongs to the technical field of drug application. In order to solve the problem that the existing antitumor activity is not much reported, the application of C-methylated high isoflavone compounds in preparation of antitumor drugs is provided, the C-methylated high isoflavone compounds are selected from compounds shown in the following formula 1 or formula 2: the C-methylated high isoflavone compounds or pharmaceutically acceptable salts thereof are used as active ingredients for preparation of antitumor drugs for preventing and / or treating adrenal pheochromocytoma (PC-12) and / or human brain astrocytoma (U-87MG). The C-methylated high isoflavone compounds have the advantages of high activity and high inhibition capacity, can be extracted from polygonatum sibiricum and have good drug safety.

The invention relates to the technical field of biological medicines, and particularly discloses a high-grade serous ovarian cancer (HGSOC) treatment strategy based on ANXA6 protein detection and regulation. The invention provides a method for evaluating the sensitivity of a patient to cisplatin chemotherapy by detecting the expression level of ANXA6 protein or a specific modification site thereof, and a composition comprising inhibiting the function of ANXA6 or combining with cisplatin. In addition, the invention also relates to a medicine application for enhancing the chemotherapy effect by regulating the activity of ANXA6 related modifying enzyme.