The invention provides an application of
aryl olefine acid
schisandra chinensis phenolic ester (O-dihydroxyphenyl) hernandezine and a derivative thereof in preparation of a
medicine for treating depression and an anti-depression
medicine prepared from the O-dihydroxyphenyl hernandezine and the derivative of the O-dihydroxyphenyl hernandezine and the derivative of the O-dihydroxyphenyl hernandezine. The application dosage is 0.01-30 mg of
aryl olefine acid
schisandra phenolic ester or the derivative thereof per
kilogram of
body weight, and the anti-depression effect can be achieved within 60 minutes after administration. After the
medicine is administrated for 5 days, a remarkable anti-depression effect can be generated at a
high dosage. A
research result shows that in a
mammal mouse
tail suspension experiment, the
aryl olefine acid
schisandra phenolic ester or the derivative thereof has a rapid anti-depression effect and is more effective than a conventional anti-depression
drug fluoxetine. According to the invention, a
forced swimming experiment and a mouse
tail suspension experiment are adopted as
drug screening experiments, and meanwhile, an
open field test is carried out on the mouse, so that the autonomous activity of the mouse is detected, and the interference of central excitation drugs is avoided. The anti-depression
drug has the advantages of being remarkable in anti-depression effect, quick in effect taking, small in dosage, small in
side effect and the like, and is expected to become a new anti-depression drug which is quick, efficient and novel in mechanism.