The invention relates to a drive running mechanism of a pipeline robot, which mainly solves the problems of the existing drive running mechanism of the pipeline robot that the pulling force is smaller, the pipe diameter adaptability is poorer, the ability of surmounting obstacles is insufficient and the like. The invention is characterized in that the drive running mechanism also comprises a wheel leg regulating motor arranged in a body, three running drive units arranged outside the body, three elastic wheel leg support units formed by combining a front support connecting rod, a rear support connecting rod and a regulating connecting rod, and a pipe diameter adaptation adjustment unit; and the body, the front support connecting rod, the rear support connecting rod and running drive units form a parallelogram wheel leg structure; after sensing the pressure from pipe walls, the pipe diameter adaptation adjustment unit regulates the front support connecting rod and the rear support connecting rod so as to adapt to the pipe diameter changes; and each running drive unit is driven by two motors so that larger pulling force can be ensured. The mechanism of the invention has larger pulling force, larger pipe diameter regulating range and better ability of surmounting the obstacles; and compared with the prior art, the mechanism has high transmission efficiency.