281results about How to "Promote bone growth" patented technology

A spinal implant may be used to stabilize a portion of a spine. The implant may promote bone growth between adjacent vertebrae that fuses the vertebrae together. An implant may include an opening through a height of a body of the implant. The body of the implant may include curved sides. A top and / or a bottom of the implant may include protrusions that contact and / or engage vertebral surfaces to prevent backout of the implant from the disc space. A variety of instruments may be used to prepare a disc space and insert an implant. The instruments may include, but are not limited to, a distractor, a rasp, and one or more guides. The implant and instruments may be supplied in an instrument kit.

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies.

An artificial spinal disc is provided for unilateral insertion from the posterior side of the patient and includes a pair of plate members with a bearing associated with one plate member and a depression associated with the other for permitting limited flexibility of patient movement. An outrigger is provided which includes rods extending through the pedicles on one side of each of two adjacent vertebrae and posts connected to the rods which provide an artificial facet joint. A method of insertion of the artificial spinal disc hereof includes cutting channels for receiving longitudinally extending ribs on the plate members and removing the natural facet joint in order to permit insertion of the artificial spinal disc. A tool for insertion of the artificial spinal disc acts as a drill guide for creating a passage through the pedicles.

Arthroplasty devices having improved bone in growth to provide a more secure connection within the body. Different embodiments disclosed include devices having threaded intramedullary components, devices configured to receive bone growth promoting substances, devices with resorbable components, and devices configured to reduce shear stress.

A system and method includes surgical instrumentation, implants, bone graft material, and measurement equipment to enable a spine fusion procedure to proceed more accurately, efficiently and safely by allowing precision measurement of the characteristics of the intervertebral space, selection of and provision of new implants, placement of an intervertebral implant, and to help overcome bone resorption all where improved healing thereafter takes place.

Adherent packed beds of ceramic beads, each comprising a ceramic body coated with a biodegradable polymer, and fabric bags containing such beads in a packed, self-supporting configuration. The polymeric coating provides some resilience to a packed bed of the ceramic beads, and prevents the beads from moving with respect to each other when placed under stress, leading to reduced breakage. The ceramic beads desirably are osteoconductive, and preferably are formed of a ceramic material that is resorbed during bone growth, such as hydroxyapatite, tricalcium phosphate, or mixtures of these materials. The beads may contain, either internally or on their surfaces or both, a bone morphogenic protein, and the latter may also be included in the biodegradable polymer coatings on the beads.

A spinal implant apparatus that is an expandable spacer including features to minimize or eliminate spacer cant or offset during and after completing the expansion process. The spacer includes a top component, a base component in engagement with the top component, and an expansion mechanism arranged to change the top component's position with respect to the base component. The mechanism for causing expansion may be a screw, a cam, a wedge or other form of distracting device. In one embodiment, the expandable spacer includes a base component with a set of towers and a top component with a set of corresponding silos, where the towers and silos are configured to minimize or eliminate tilt of the top component as it extends upwardly from the base component. In another embodiment, the spacer may include a stepped arrangement around the perimeter of the top component and the base component for engagement during height expansion with minimal canting or slippage. In another embodiment, the spacer may include texturing modification at the opposite ends of the longitudinal axis of the spacer to prevent tilting, slipping, or canting. Additionally, a portion of one or more exterior surfaces of the spacer may be textured, sawtoothed, dovetailed or the like to increase frictional intervertebral contact. The spacer may contain one or more passageways of selectable shape / dimension for bone growth through the spacer.

A method of inhibiting formation of a stress riser in a bone is provided. The method is comprised of providing a bone having a first device and replacing the first device with a second device. Both the first device and the second device are substantially cylindrical, with the diameter of the second device being larger than that of the first device. Formation of a stress riser is inhibited in the presence of the second device.

The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and / or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and / or nanotubes.

A bone anchor for use in conjunction with orthopedic spinal fixation comprising a pedicle screw having a threaded proximal tip for threaded insertion into a hole prepared into a vertebral body through the pedicle of the vertebra from the posterior approach. The shank of the anchor is of smaller diameter than the proximal tip so as to receive a sleeve after insertion into the bone. The tubular sleeve is provided with a plurality of longitudinal slots evenly arranged about the longitudinal axis of the sleeve to forming a plurality of longitudinal. A tubular compression collar for insertion over said shank portion is provided on the shank and driven toward the proximal tip compression the sleeve and causing the ribs to expand radially into a star pattern securing the anchor in the bone. A tubular collar of natural or synthetic bone growth promoting material may be inserted to promote bone growth, close the hole and further stabilize the anchor. An elastomeric collar may also be inserted over the shank and extend beyond the end of the shank to flexibly receive a rod seat for receiving an orthopedic rod affixed to said elastomeric collar.

A graft fixation device, system and method are disclosed for reconstruction or replacement of a ligament or tendon preferably wherein a soft tissue graft or a bone-tendon-bone graft is received and implanted in a bone tunnel. The graft fixation system includes a fixation device comprising a threaded body which is rotatably connected to a graft interface member. One embodiment of the implant / graft interface member includes an enclosed loop for holding a soft tissue graft. Another embodiment of the interface member includes a bone cage comprising a cage bottom and removable cage top to hold a bone block at one end of a bone-tendon-bone (BTB) graft. An additional embodiment of the interface member includes a one-piece bone cage which may be crimped or stapled to a bone block. The fixation device holds a graft in centered axial alignment in a bone tunnel. The body portion of the fixation device may be turned without imparting substantial twist to a graft attached to the device, due to the rotatable coupling between the threaded body and the interface member. The fixation device may be installed using a driver tool that has a shaft and an outer sleeve, wherein the driver may be used to twist the fixation device and independently exert a pushing or pulling force thereto. The graft fixation method may be used to install a fixation device by pulling or pushing it into a prepared bone tunnel while minimizing the possibility of abrasion or other damage to a graft attached to the fixation device.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

The present invention relates to a composition for maintenance of bone health or prevention, alleviation and / or treatment of bone disorders. It also relates to the use of the composition in the manufacture of a nutritional product, a supplement, a treat or a medicament; and a method of promoting bone growth or for the maintenance of bone health, which comprises administering an effective amount of the composition.

This invention relates to a porous bone implant (10, 110, and 210), a method of manufacturing the implant and a method of orthopedic treatment. The mesh implant can be manufactured using extrusion techniques and a variety of cutting and machining processes to provide the implant with the desired structural features and in the required dimensions to be matingly received within the bone defect or cavity. The implant can be used to strengthen bone structures and support bone tissue adjacent to a defect of cavity. Thus, the implant can be used to provide improved treatment of patients having bone defects or diseases with decreased postoperative pain and a shorter recovery time.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A method of performing surgery to enable joint fusion by preparing bony surfaces of a joint to create an enlarged space between sides of the joint in which subchondral bone of the joint is exposed, inserting a hollow structural implant, having at least two large fenestrations which are located on substantially opposite sides of the implant into the enlarged space so that the implant contacts the subchondral bone and orientating the implant so that the large fenestrations are located adjacent the subchondral bone on respective sides of the joint.

The present invention relates to biomedical implants for bone substitution and replacement applications. The implant includes a strong, porous polymeric or thermoplastic compositions and growth-enhancing compositions.

An implantable spinous process fixation device includes an elongated component, top and bottom pivoting wing components, arranged opposite and parallel to the elongated component and separated from it by a spacer. First and second spinous processes of first and second adjacent vertebras are clamped between a top portion of the elongated component and the top pivoting wing and between a bottom portion of the elongated component and the bottom pivoting wing, respectively, by pivoting the top and bottom pivoting wings toward the top and bottom portions of the elongated component. The clamping of the spinous processes stabilizes the positions of the adjacent vertebras and prevents them from moving relative to each other.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.

A spinal stabilization system may include a pair of structural members coupled to at least a portion of a human vertebra with connectors. Connectors may couple structural members to spinous processes. Some embodiments of a spinal stabilization system may include fasteners that couple structural members to vertebrae. In some embodiments, a spinal stabilization system provides three points of fixation for a single vertebral level. A fastener may fixate a facet joint between adjacent vertebrae and couple a stabilization structural member to a vertebra. Connectors may couple the structural members to the spinous processes of the vertebrae. Use of a spinal stabilization system may improve the stability of a weakened or damaged portion of a spine. When used in conjunction with an implant or other device, the spinal stabilization system may immobilize vertebrae and allow for fusion of the implant or other device with vertebrae.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

A tibial tuberosity advancement implant with first and second arms pivotally joined at an apex. Tabs including anchor apertures extend from each arm for attachment of the arms in a traverse osteotomyized tibia. A selection of various width keys are each insertable between the arms for setting the distance between the arms and the width of the osteotomyized tibia.

A reduced pressure delivery system for applying a reduced pressure to a tissue site includes a manifold delivery tube having a passageway and a distal end, the distal end configured to be percutaneously inserted and placed adjacent the tissue site. A flowable material is provided and is percutaneously deliverable through the manifold delivery tube to the tissue site. The flowable material is capable of filling a void adjacent the tissue site to create a manifold having a plurality of flow channels in fluid communication with the tissue site. A reduced pressure delivery tube is provided that is capable of fluid communication with the flow channels of the manifold.