14 results about "Synthetic bone" patented technology

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

Osteoinductive materials and modular bioactive synthetic bone craft (MST) devices are provided. The MST devices comprise the osteoinductive materials for applications in regenerative medicine and treatment of diseases. The osteoinductive material can be characterized by a scaffold filament, a hydrogel layer cross-linked with the scaffold filament, and an osteoinductive growth factor. The hydrogel layer contains the osteoinductive growth factor, a covalent cross-linking polymer, a covalent cross-linking monomer, and a physical cross-linking polymer.

The invention relates to the technical field of bone china, and particularly discloses a production process of synthetic bone meal for bone china, which comprises the following steps: S1, mixing calcium hydroxide and water according to a mass ratio of 1: 3 to prepare a calcium hydroxide emulsion; s2, the calcium hydroxide emulsion sequentially passes through four iron removal devices to be subjected to iron removal treatment, and the content of Fe2O3 in a final product is smaller than or equal to 0.12%; s3, hot-process phosphoric acid with the mass fraction of 85% and water are mixed according to the volume ratio of 1: 1, and a phosphoric acid solution is obtained; s4, under the condition of continuous stirring, uniformly adding the phosphoric acid solution into the calcium hydroxide emulsion according to the stoichiometric ratio calculated by complete reaction; by adopting the four-stage series iron removal device and combining online feedback adjustment, metal impurities in raw materials are effectively removed; the dripping speed and the reaction temperature of the phosphoric acid solution are accurately controlled in cooperation with a constant flow pump, and the uniformity and the stability of a reaction system are ensured, so that the chemical purity of the synthesized bone meal is remarkably improved, impurity interference is reduced, and a high-quality product with high whiteness and high light transmittance is obtained.

This invention is in the field of artificial skeletal muscle. The present invention relates to a method for producing artificial skeletal muscle tissue from pluripotent stem cells, comprising five defined steps, whereby contractile artificial skeletal muscle tissue is produced, and the method is characterized in that steps (i) - (iii) are carried out in a bioreactor under suitable conditions, and wherein the method does not include the use of a solubilized basement membrane preparation extracted from Engelbreth-Holm swarm mouse sarcoma.Furthermore, an artificial skeletal muscle tissue is disclosed, obtainable by a method disclosed herein, wherein the artificial skeletal muscle tissue generates a contraction force of at least 0.5 millinewtons (mN) upon stimulation of 1 Hz to 150 Hz, wherein the artificial skeletal muscle tissue is serum-free, and wherein the artificial skeletal muscle tissue does not include a transgene. Medical and non-medical uses of the artificial skeletal muscle tissue are also described.

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

The present application relates to the field of bone tissue engineering materials, and relates to a synthetic bone repair material with a biomimetic structure.The present application prepares a nano wool protein / hydroxyapatite composite biomimetic bone material through an in-situ mineralization process, and the wool material is dissolved, purified, dialyzed and separated and purified to obtain a wool protein solution.The wool protein solution is mixed with a calcium ion solution, and a proper surfactant, a pH value regulator and a performance control substance are added to obtain a precursor solution.On this basis, the in-situ mineralization reaction is carried out by dropping the phosphate to obtain the nano wool protein / hydroxyapatite composite biomimetic bone material.The composite biomimetic bone material obtained by the in-situ mineralization deposition has high rigidity and toughness, can simulate the organic / inorganic components in human bones, and has good bone replacement performance.

1. A surgical training device comprising a housing and a cassette, wherein the housing comprises a synthetic layer for simulating skin, the cassette for holding one or more organ models in anatomical relationship to one another, the cassette being substantially surrounded by the housing and thereby engageable with the housing to define a body cavity, and the cassette comprising synthetic bony anatomical features as landmarks.

Techniques, including wearable audio devices and systems implementing the techniques, for synthesizing bone conduction speech. Such techniques may include (i) inputting a first acoustic signal into a first machine-learning model, (ii) generating, with the first machine-learning model, a first bone conduction signal in a time domain or a spectral domain based, at least in part, on the first acoustic signal, (iii) generating, with the first machine-learning model, a transfer function that characterizes a relationship between the first acoustic signal and the first bone conduction signal based, at least in part, on the first acoustic signal, and (iv) training, using at least one of the first bone conduction signal or the transfer function, a second machine-learning model on a first device.

The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order.The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.

A bioactive filamentary structure includes a sheath coated with a mixture of synthetic bone graft particles and a polymer solution forming a scaffold structure. In forming such a structure, synthetic bone graft particles and a polymer solution are applied around a filamentary structure. A polymer is precipitated from the polymer solution such that the synthetic bone graft particles and the polymer coat the filamentary structure and the polymer is adhered to the synthetic bone graft particles to retain the graft particles.

The present invention relates to a medical device manufactured using a layered manufacturing method (3D printing). This medical device comprises a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite and is preferably used as a bone graft. Its composition may or may not include nanostructures, for example, carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.), and in a preferred embodiment, stem cells and a polymer membrane. The present invention also relates to the use of this device as a bone graft and the manufacturing process of this device.

The present disclosure provides compositions and methods treating spinal conditions using interbody lumbar fusion. The compositions comprise β-TCP as a ceramic scaffold and a chimeric recombinant BMP -2 (tBMP-2), which has a portion of BMP-2 fused to several β-TCP binding peptides. The β-TCP and tBMP-2 are associated non-covalently. The method may be used with interbody cages, wherein the interbody cage comprises titanium, polyetheretherketone (PEEK), polyetherketoneketone (PEKK), carbon fiber, grafted or synthetic bone, or any combination thereof. The surgical procedures can be selected from Transforaminal Lumbar Interbody Fusion (TLIF), Lateral Lumbar Interbody Fusion (LLIF), Posterior Lumbar Interbody Fusion (PLIF), Anterior Lumbar Interbody Fusion (ALIF), Oblique Lateral Interbody Fusion (OLIF), and Extreme Lateral Interbody Fusion (XLIF), Interspinous Process Fusion (ILIF), Anterior Cervical Discectomy and Fusion (ACDF), Posterior Spinal Fusion (PSF), Posterolateral Spinal Fusion (PLF) facet fusion, interspinous fusion, Sacroiliac Joint Fusion, or Kyphoplasty.

The application discloses a camera integrated device and method for maxillary sinus mucosa lifting and synthetic bone delivery, which comprises a main handle, an operation tube installed at the front end of the main handle, a male connector socket installed at the rear end of the main handle, and a camera module installed inside the front end of the operation tube; a transparent protective cover is combined with the front end of the operation tube, and an umbrella-shaped outer edge is arranged on the outer edge of the front end of the operation tube, which is used for controlling the lifting of the maxillary sinus mucosa and providing structural support for the transparent protective cover. The application combines the visual camera module with the sinus mucosa lifting tool, so that real-time observation of the mucosa and the operation area can be realized during the maxillary sinus mucosa lifting process. By providing direct visual guidance, more accurate control of the lifting force and direction of the mucosa is realized, so that the risk of mucosa perforation is effectively reduced, and the safety of the operation is improved.