36 results about "Bone transplantation" patented technology

The present disclosure is directed to a method of preparing an osteogenic bone graft. The method includes introducing an anticoagulant compound into a volume of cellular material including a mononuclear cell population from the intramedullary canal of a long bone; collecting an effluent including the volume of cellular material containing the anticoagulant compound at a collection point; separating a concentrated cell fraction from the effluent, the concentrated cell fraction including the mononuclear cell population and the anticoagulant compound; and preparing an osteogenic bone graft from the concentrated cell fraction.

The present invention discloses a bone shaping instrument for oral and maxillofacial surgery, including a support with an installation cavity inside; a waste liquid collection tank fixed on the top wall of the support; a support column fixedly connected to the support, and a controller on the support column; a work surface horizontally arranged just above the waste liquid collection tank, and liquid permeable holes evenly distributed on the work surface; a lifting part arranged on the support column, which has a lifting end and a manual operation end, and the work surface is connected to the lifting end; a fixing part arranged on the work surface; a cutting part arranged on the support column, and the cutting part is composed of a first speed regulating motor and a saw blade; a shaping part arranged in the installation cavity of the support, and the shaping part includes a second speed regulating motor, and the driving shaft of the second speed regulating motor horizontally passes through the side wall of the support, and a shaping grinding head is coaxially arranged at the outer end of the driving shaft; and a power supply is arranged in the installation cavity of the support. The advantage of the present invention is that it can easily realize the cutting and grinding of the bone body to be shaped during oral and maxillofacial bone transplantation, and realize multiple uses of one machine.

Bone transplant made of a cortical bone substance having a screw shank and a screw head for introducing a screwing-in torque. Both the screw shank and the screw head are provided with an external thread, in which at least the external thread of the screw shank is a multi-start thread. Due to the design, on the one hand a certain stroke can be achieved with fewer revolutions or in a shorter time, whereby the screwing-in behavior is improved and the tendon tissue is protected. On the other hand, the use of multiple threads provides a high surface area for the tendon tissue to grow on the tendon anchor, which improves fixation of the tendon and increases rotational stability. The bone transplant according to the invention thus ensures good fixation of the tendon and can be implanted quickly.

According to a first aspect, there is provided a bone graft substitute comprising coral particles. The coral material of the coral particles has a pore volume of below 15%. According to a second aspect, there is provided a bone graft substitute comprising coral particles, wherein the bone graft substitute has an overall pore volume comprising an inter-particle pore volume defined by voids between coral particles and an intra-particle pore volume defined by voids within coral particles, said overall pore volume being at least 40%, and said intra-particle pore volume being below 15%.

The invention discloses a silk material with a function of promoting cell proliferation and application of the silk material. According to the functional material, a human-derived I-type collagen truncated fragment is expressed by a silkworm middle silk gland, and a sericin promoter serving as a tissue-specific promoter can drive an exogenous gene to be specifically expressed in the middle silk gland; finally, the silkworm cocoons are combined with sericin to be secreted in vitro, foreign protein can be separated after certain treatment is carried out on the silkworm cocoons, and the expression product can maintain biological activity. The hydrogel prepared from the silk material has the effect of promoting wound healing, and can be applied to the aspects of promoting skin regeneration and repair, bone transplantation substitutes, cartilage reconstruction, artificial skin and the like.

The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

A device (1) for supporting bone tissue growth at a bone defect comprises a deformable semipermeable pouch (10) made of a bioabsorbable material and bone graft granules (40) enclosed by the deformable semipermeable pouch (10). The bone graft granules (40) comprise a calcium salt. The deformable semipermeable pouch (10) comprises at least one through hole (20, 22, 24, 26) arranged and dimensioned for reception of a fastening screw (50) configured to screw into a bone and attach the deformable semipermeable pouch (10) at the bone.

The application discloses a silk material with a cell proliferation function and application thereof, the functional material is expressed by a human type I collagen truncated fragment in a middle silk gland of a domestic silkworm, a sericin promoter is used as a tissue-specific promoter to drive specific expression of an exogenous gene in the middle silk gland, and finally the exogenous gene is combined with sericin protein and is secreted to outside of the body, the exogenous protein can be separated after a certain treatment of a cocoon, and the expression product can keep biological activity. The silk material is used to prepare a hydrogel, has a function of promoting wound healing, and can be applied to aspects of promoting skin regeneration and repair, bone graft substitutes, cartilage reconstruction, artificial skin and the like.

Provided herein are formulations for treating bone graft materials prior to implantation. Treating the bone graft materials with the formulations disclosed herein can restore the physiological and biochemical characteristics of bone. The bone graft can be a bone allograft. Also provided herein are methods for preparing the formulations and methods for preparing a bone graft for transplantation.

The present invention discloses an absorbable bone wax and its preparation method and application. The absorbable bone wax, by mass fraction, comprises the following raw materials: 5-10 parts of hydroxyethyl silane, 10-30 parts of polyethylene glycol α-tocopherol succinate, 10-50 parts of multi-carboxyl substituted chitosan, and 1-5 parts of strontium salt. The absorbable bone wax of the present invention has a dense structure, excellent viscosity, and excellent ductility and stability. It is used for preparing or directly serving as a bone hemostasis, bone defect or bone transplantation repair material, and has various functions such as promoting rapid mechanical hemostasis of bone cross-sections and promoting bone repair and regeneration. In addition, the absorbable bone wax of the present invention has controllable degradation and can meet the requirements of different clinical scenarios.

This invention discloses a dental bone graft material processing device, comprising a main unit, which includes a control unit, a reaction chamber, a graft material chamber, and booster pumps. One booster pump is connected to the air inlet / outlet on the reaction chamber, and the remaining booster pumps are connected to each of the drug solution chambers. The graft material chamber is composed of an upper section, a middle section, and a lower section connected together. The middle and lower sections are hollow cylinders, and a filter screen is installed at their connection. The upper section is an integral structure with a cover and an air passage connected to the middle section. An air inlet connected to the air passage is also provided on the upper section. A first annular groove is formed between the air inlet and the cover, and a first sealing ring is installed inside the groove. The centerline of the cover and the air passage coincides with the centerline of the middle and lower sections. The control unit controls the amount of distilled water and each drug solution chamber fed into the reaction chamber, the driving of the peristaltic pump, the driving of the booster pump, and the driving of the vibration device. The device of this invention has a simple structure, small size, low cost, and can quickly and completely discharge waste liquid.

The present invention provides a method of manufacturing a coral scaffold for use as a bone graft substitute. The method comprises growing coral in a growth medium having a carbonate hardness, dKH, of 10 or more; removing at least a portion of the coral from the growth medium; devitalising coral removed from the growth medium and sizing the devitalised coral to form the coral scaffold.

This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

The present invention provides bone grafts, such as allografts, and methods of releasing growth factors from tissues with native living cells, such as bone marrow, bone matrix, adventitia and / or inventitia. Also provided are compositions comprising growth factors and uses of the compositions to improve osteoinductivity of implants, such as bone grafts.

The invention discloses a preparation method of an antler-DCB bone transplantation scaffold material, which specifically comprises the following steps: S1, cutting the cancellous bone of an antler into a bone sample, and carrying out ultrasonic treatment; s2, soaking in ethanol, and shaking with a shaking table; s3, soaking in diethyl ether, and shaking with a shaking table; s4, soaking the bone sample in a sodium hydroxide solution for shaking table oscillation, cleaning the bone sample with flowing water after soaking, treating the bone sample with hydrogen peroxide with the mass fraction of 30% for 24 hours after cleaning, and cleaning the bone sample again after treatment; and S5, putting the cleaned bone sample into a mixture of chloroform and methanol in a volume ratio of 3: 1 for 1 hour, washing the bone sample with distilled water, and drying at 70 DEG C for 1 day to prepare the antler-DCB bone transplantation scaffold material. The invention also discloses the antler-DCB bone transplantation scaffold material. According to the antler-DCB bone transplantation scaffold material and the preparation method thereof disclosed by the invention, the antler-DCB bone transplantation scaffold material has high porosity, large aperture and specific surface area, and is more beneficial to bone regeneration.

The invention discloses minimally invasive bone taking equipment, and relates to the technical field of medical instruments, the minimally invasive bone taking equipment comprises a cutting tool, the cutting tool comprises a tubular tool body, the cutting end of the tool body is provided with a cutting edge, the cutting edge comprises a first cutting edge and a second cutting edge, the first cutting edge is zigzag, and the second cutting edge is zigzag; the orientation of the first cutting edge is parallel to the axial direction of the cutter body; the other end of the cutter body is a second end, and the second cutting edge inclines towards the inner side of the cutter body; the second end of the rotary collecting bin is connected with one end of the rotary collecting bin, and bone tissue obtained through cutting of the cutting tool can move into the rotary collecting bin through the interior of the tool body; and the power part is used for driving the rotary collecting bin and the cutting tool to rotate around the axis of the tool body. The strip-shaped bone blocks are obtained through the design of the second cutting edge on the cutting tool, the power component drives the cutting tool and the rotary collecting bin to rotate, and the purpose of obtaining the complete strip-shaped bone blocks in the minimally invasive autogenous bone transplantation surgery is achieved.

The invention discloses a cartilage graft and a construction method thereof. The cartilage graft is a cartilage membrane or an injectable cartilage graft; the cartilage graft contains cartilage membranes or cartilage micro-tissues formed by in-vitro culture of cartilage cells.

The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order.The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.

The invention provides a small animal allogeneic bone cartilage transplantation instrument. The small animal allogeneic bone cartilage transplantation instrument is characterized by comprising a small animal defect model making device and an allogeneic bone cartilage graft extracting and implanting device which are matched for use, wherein the small animal defect model making device comprises a sharp-bottomed manual bone grinding drill and a flat-bottomed manual bone grinding drill; the sharp-bottomed manual bone grinding drill is used for preliminarily making a small animal defect model; the flat-bottom manual bone grinding drill is used for leveling and shaping the small animal defect model; the allogeneic bone cartilage graft extracting and implanting device comprises a multifunctional transplanter and a multifunctional measurer, the multifunctional transplanter is used for extracting an allogeneic bone cartilage graft; and the multifunctional measurer measures the depth of the small animal defect model and pushes the allogeneic bone cartilage graft extracted from the multifunctional transplanter into the small animal defect model. The device can be used for simply and quickly manufacturing the small animal bone cartilage transplantation model with high quality.

The invention discloses bone transplantation minimally invasive equipment and a bone taking method thereof, and belongs to the field of medical instruments. The hollow drill bit is used for drilling bone tissue, meanwhile, the drilled bone tissue and bone marrow are collected through negative pressure suction, the purpose of fully automatically obtaining autogenous bone and bone marrow through a minimally invasive channel is achieved, and effective separation and independent collection of solid bone tissue and bone marrow are achieved. According to the invention, the drilled bone tissue material is directly adsorbed and collected into the first collecting cavity under negative pressure, so that mechanical damage and thermal damage to the bone tissue in the process of collecting and conveying the bone tissue material by adopting a spiral conveying mechanism and other mechanical mechanisms are avoided. According to the bone taking method implemented by adopting the bone transplantation minimally invasive equipment, effective bioactive components such as stem cells and growth factors in the separated bone marrow can be quickly enriched in artificial bones or autogenous bones in the process of obtaining bone transplantation materials, so that the biological activity of the artificial bones or the autogenous bones is achieved; the synchronous implementation of the biological activity recovery of the artificial bone and the acquisition of the bone tissue material is realized.

The invention discloses a modulus-controllable bionic gradient porous medical titanium alloy and an additive manufacturing process method thereof, and relates to the technical field of medical materials.The titanium alloy is formed by stacking a plurality of rhombic dodecahedron structures in the vertical direction; the rhombic dodecahedron structure is formed by stacking a plurality of rhombic dodecahedron structure layers with the same area, and each rhombic dodecahedron structure layer is formed by arranging a plurality of rhombic dodecahedron unit cell structures in an array mode in the same horizontal plane. And the top distances of the rhombic dodecahedron unit cell structures in the rhombic dodecahedron structures from top to bottom are sequentially increased. The elastic modulus can be effectively reduced to 0.14-0.43 GPa, the elastic modulus of the whole structure can be accurately controlled, and the stress shielding effect of the bone graft is relieved.

The embodiments of the present invention disclose a periosteal material for promoting local endogenous bone regeneration and repair, and a preparation method thereof. The method comprises: dissolving GelMA in PBS to obtain a GelMA solution; adding a photoinitiator, HAAMMA, and E7 peptide to the GelMA solution, and conducting a free radical polymerization reaction under ultraviolet light to obtain a polymer product; washing the polymer product, freeze-drying, and sterilizing to obtain the periosteal material; wherein the HAAMMA is MA-modified HAAM. The present invention provides a bone tissue engineering membrane material prepared using GelMA, HAAM, and E7 peptide as raw materials, which can promote both stem cell recruitment and osteoblast differentiation into bone in the bone defect area, i.e., a biomimetic periosteal material with osteogenesis-promoting function, to address the problems of poor graft survival, healing, and slow healing after bone transplantation in large bone defects.

The present invention relates to a bone graft composition comprising: a ceramic component comprising calcium phosphate compound particles, bioactive glass, or both thereof; and a hydrogel component comprising a cellulose-based polymer and polyacrylic acid.

The present invention relates to a method of preparing a bone graft composition, comprising the steps of: (1) preparing a bone morphogenetic protein solution by mixing a solvent and a bone morphogenetic protein; (2) mixing the bone morphogenetic protein solution with porous bone graft material powder having an average particle diameter of 200 μm to 5,000 μm, and performing centrifugal separation using a refrigerated centrifuge in a cold temperature state of 5°C or less to cause the bone morphogenetic protein to be physically adsorbed to the surface or inside the pores of the porous graft material powder; (3) mixing and stirring 1 part by weight of the graft material powder having the bone morphogenetic protein adsorbed thereto and 0.3 parts by weight to 3 parts by weight of hydroxypropyl methylcellulose powder based on 1 part by weight of the graft material powder to form a gel; and (4) forming a sponge-like structure in which the graft material powder is fixed within a high-molecular network formed by the hydroxypropyl methylcellulose by freeze-drying the gel under vacuum.

The invention relates to the technical field of oral bone transplantation, and provides a bone transplantation positioning method, system and device for an oral implant bone increment surgery, and the method comprises the steps: building an oral implant bone transplantation data sharing network; obtaining weight coefficients of other oral hospitals except the target oral hospital in the oral implant bone transplantation data sharing network; acquiring feature information of a bone defect area according to the oral medical image; respectively calculating the correlation degree between the bone transplantation information of the target oral bone transplantation patient and the bone transplantation information of other oral bone transplantation patients; and acquiring bone transplantation positioning information according to the weight coefficient, the bone defect area feature information and the association degree, and processing the autologous blocky bone according to the bone transplantation positioning information to realize bone transplantation positioning of the oral implant bone increment surgery. According to the method, the bone transplantation data information of multiple different dimensions is comprehensively considered, the autologous blocky bone treatment process can be optimized, and the bone transplantation positioning precision and the intelligent degree of the oral implant bone are improved.

A method of making infused bone fibers employs the following steps: cutting or shaving whole bone into bone fibers, washing the bone fibers, demineralizing or decalcifying at least partially the whole bone or bone fibers and infusing the bone fibers with a supernatant of biologic material or a polyampholyte cryoprotectant or a combination of both to create infused bone fibers. The step of infusing includes exposing the bone fibers to a negative pressure or vacuum to draw the supernatant and / or the polyampholyte cryoprotectant into the bone fibers, or alternatively, exposing the demineralized whole bone to a positive pressure to drive the supernatant and / or the polyampholyte cryoprotectant into the bone. The resultant method creates an infused bone grafting composition having bone fibers taken from whole bone, demineralized or decalcified at least partially and infused with one or more of a supernatant of biologic material or a polyampholyte cryoprotectant or both.

The invention relates to a medical device manufactured using an additive manufacturing process (3D printing). The present invention relates to a medical device, preferably for use as a bone graft, consisting of a porous structure of a bioceramic based on beta-tricalcium phosphate (beta-TCP) or hydroxyapatite, the composition of which may contain or do not contain nanostructures, ), for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc., as well as stem cells and polymer membranes in preferred embodiments. The invention further relates to the use of the device as a bone graft and to a method for producing the device.

A method for producing non-resorbable bone allografts having improved osteoconductivity and biocompatibility in regenerative dental and medical applications as compared with non-resorbable xenografts. The method comprises excising one or more bone allografts from a donor's body; freeze-drying the bone allografts; demineralizing the freeze-dried bone allografts; preserving and sterilizing the bone allografts; and thermal processing of the bone allografts at a temperature greater than about 300 degrees Celsius.