25 results about "Bone transplantation" patented technology

According to a first aspect, there is provided a bone graft substitute comprising coral particles. The coral material of the coral particles has a pore volume of below 15%. According to a second aspect, there is provided a bone graft substitute comprising coral particles, wherein the bone graft substitute has an overall pore volume comprising an inter-particle pore volume defined by voids between coral particles and an intra-particle pore volume defined by voids within coral particles, said overall pore volume being at least 40%, and said intra-particle pore volume being below 15%.

The invention discloses a silk material with a function of promoting cell proliferation and application of the silk material. According to the functional material, a human-derived I-type collagen truncated fragment is expressed by a silkworm middle silk gland, and a sericin promoter serving as a tissue-specific promoter can drive an exogenous gene to be specifically expressed in the middle silk gland; finally, the silkworm cocoons are combined with sericin to be secreted in vitro, foreign protein can be separated after certain treatment is carried out on the silkworm cocoons, and the expression product can maintain biological activity. The hydrogel prepared from the silk material has the effect of promoting wound healing, and can be applied to the aspects of promoting skin regeneration and repair, bone transplantation substitutes, cartilage reconstruction, artificial skin and the like.

The disclosure provides bone graft materials, methods for their use and manufacture. Exemplary bone graft materials comprise combining a radiopaque component with a cancellous bone component to produce a bone graft material, wherein the cancellous bone component comprises native osteoreparative cells. Methods for treating a subject with the bone graft material are also provided.

A device (1) for supporting bone tissue growth at a bone defect comprises a deformable semipermeable pouch (10) made of a bioabsorbable material and bone graft granules (40) enclosed by the deformable semipermeable pouch (10). The bone graft granules (40) comprise a calcium salt. The deformable semipermeable pouch (10) comprises at least one through hole (20, 22, 24, 26) arranged and dimensioned for reception of a fastening screw (50) configured to screw into a bone and attach the deformable semipermeable pouch (10) at the bone.

The application discloses a silk material with a cell proliferation function and application thereof, the functional material is expressed by a human type I collagen truncated fragment in a middle silk gland of a domestic silkworm, a sericin promoter is used as a tissue-specific promoter to drive specific expression of an exogenous gene in the middle silk gland, and finally the exogenous gene is combined with sericin protein and is secreted to outside of the body, the exogenous protein can be separated after a certain treatment of a cocoon, and the expression product can keep biological activity. The silk material is used to prepare a hydrogel, has a function of promoting wound healing, and can be applied to aspects of promoting skin regeneration and repair, bone graft substitutes, cartilage reconstruction, artificial skin and the like.

Provided herein are formulations for treating bone graft materials prior to implantation. Treating the bone graft materials with the formulations disclosed herein can restore the physiological and biochemical characteristics of bone. The bone graft can be a bone allograft. Also provided herein are methods for preparing the formulations and methods for preparing a bone graft for transplantation.

The present invention discloses an absorbable bone wax and its preparation method and application. The absorbable bone wax, by mass fraction, comprises the following raw materials: 5-10 parts of hydroxyethyl silane, 10-30 parts of polyethylene glycol α-tocopherol succinate, 10-50 parts of multi-carboxyl substituted chitosan, and 1-5 parts of strontium salt. The absorbable bone wax of the present invention has a dense structure, excellent viscosity, and excellent ductility and stability. It is used for preparing or directly serving as a bone hemostasis, bone defect or bone transplantation repair material, and has various functions such as promoting rapid mechanical hemostasis of bone cross-sections and promoting bone repair and regeneration. In addition, the absorbable bone wax of the present invention has controllable degradation and can meet the requirements of different clinical scenarios.

The present invention provides a method of manufacturing a coral scaffold for use as a bone graft substitute. The method comprises growing coral in a growth medium having a carbonate hardness, dKH, of 10 or more; removing at least a portion of the coral from the growth medium; devitalising coral removed from the growth medium and sizing the devitalised coral to form the coral scaffold.

This invention provides a fluid therapeutic placental product comprising placental cells and a placental dispersion comprising placental factors. The placental cells and the placental dispersion are derived from placental tissue. A placental tissue can optionally be an amnion, chorion, or a trophoblast-depleted chorion. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

The present invention provides bone grafts, such as allografts, and methods of releasing growth factors from tissues with native living cells, such as bone marrow, bone matrix, adventitia and / or inventitia. Also provided are compositions comprising growth factors and uses of the compositions to improve osteoinductivity of implants, such as bone grafts.

The invention discloses a cartilage graft and a construction method thereof. The cartilage graft is a cartilage membrane or an injectable cartilage graft; the cartilage graft contains cartilage membranes or cartilage micro-tissues formed by in-vitro culture of cartilage cells.

The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order.The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.

The invention discloses bone transplantation minimally invasive equipment and a bone taking method thereof, and belongs to the field of medical instruments. The hollow drill bit is used for drilling bone tissue, meanwhile, the drilled bone tissue and bone marrow are collected through negative pressure suction, the purpose of fully automatically obtaining autogenous bone and bone marrow through a minimally invasive channel is achieved, and effective separation and independent collection of solid bone tissue and bone marrow are achieved. According to the invention, the drilled bone tissue material is directly adsorbed and collected into the first collecting cavity under negative pressure, so that mechanical damage and thermal damage to the bone tissue in the process of collecting and conveying the bone tissue material by adopting a spiral conveying mechanism and other mechanical mechanisms are avoided. According to the bone taking method implemented by adopting the bone transplantation minimally invasive equipment, effective bioactive components such as stem cells and growth factors in the separated bone marrow can be quickly enriched in artificial bones or autogenous bones in the process of obtaining bone transplantation materials, so that the biological activity of the artificial bones or the autogenous bones is achieved; the synchronous implementation of the biological activity recovery of the artificial bone and the acquisition of the bone tissue material is realized.

The invention discloses a modulus-controllable bionic gradient porous medical titanium alloy and an additive manufacturing process method thereof, and relates to the technical field of medical materials.The titanium alloy is formed by stacking a plurality of rhombic dodecahedron structures in the vertical direction; the rhombic dodecahedron structure is formed by stacking a plurality of rhombic dodecahedron structure layers with the same area, and each rhombic dodecahedron structure layer is formed by arranging a plurality of rhombic dodecahedron unit cell structures in an array mode in the same horizontal plane. And the top distances of the rhombic dodecahedron unit cell structures in the rhombic dodecahedron structures from top to bottom are sequentially increased. The elastic modulus can be effectively reduced to 0.14-0.43 GPa, the elastic modulus of the whole structure can be accurately controlled, and the stress shielding effect of the bone graft is relieved.

The embodiments of the present invention disclose a periosteal material for promoting local endogenous bone regeneration and repair, and a preparation method thereof. The method comprises: dissolving GelMA in PBS to obtain a GelMA solution; adding a photoinitiator, HAAMMA, and E7 peptide to the GelMA solution, and conducting a free radical polymerization reaction under ultraviolet light to obtain a polymer product; washing the polymer product, freeze-drying, and sterilizing to obtain the periosteal material; wherein the HAAMMA is MA-modified HAAM. The present invention provides a bone tissue engineering membrane material prepared using GelMA, HAAM, and E7 peptide as raw materials, which can promote both stem cell recruitment and osteoblast differentiation into bone in the bone defect area, i.e., a biomimetic periosteal material with osteogenesis-promoting function, to address the problems of poor graft survival, healing, and slow healing after bone transplantation in large bone defects.

The present invention relates to a method of preparing a bone graft composition, comprising the steps of: (1) preparing a bone morphogenetic protein solution by mixing a solvent and a bone morphogenetic protein; (2) mixing the bone morphogenetic protein solution with porous bone graft material powder having an average particle diameter of 200 μm to 5,000 μm, and performing centrifugal separation using a refrigerated centrifuge in a cold temperature state of 5°C or less to cause the bone morphogenetic protein to be physically adsorbed to the surface or inside the pores of the porous graft material powder; (3) mixing and stirring 1 part by weight of the graft material powder having the bone morphogenetic protein adsorbed thereto and 0.3 parts by weight to 3 parts by weight of hydroxypropyl methylcellulose powder based on 1 part by weight of the graft material powder to form a gel; and (4) forming a sponge-like structure in which the graft material powder is fixed within a high-molecular network formed by the hydroxypropyl methylcellulose by freeze-drying the gel under vacuum.

The invention relates to the technical field of oral bone transplantation, and provides a bone transplantation positioning method, system and device for an oral implant bone increment surgery, and the method comprises the steps: building an oral implant bone transplantation data sharing network; obtaining weight coefficients of other oral hospitals except the target oral hospital in the oral implant bone transplantation data sharing network; acquiring feature information of a bone defect area according to the oral medical image; respectively calculating the correlation degree between the bone transplantation information of the target oral bone transplantation patient and the bone transplantation information of other oral bone transplantation patients; and acquiring bone transplantation positioning information according to the weight coefficient, the bone defect area feature information and the association degree, and processing the autologous blocky bone according to the bone transplantation positioning information to realize bone transplantation positioning of the oral implant bone increment surgery. According to the method, the bone transplantation data information of multiple different dimensions is comprehensively considered, the autologous blocky bone treatment process can be optimized, and the bone transplantation positioning precision and the intelligent degree of the oral implant bone are improved.

The present invention relates to a medical device manufactured using a layered manufacturing method (3D printing). This medical device comprises a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite and is preferably used as a bone graft. Its composition may or may not include nanostructures, for example, carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.), and in a preferred embodiment, stem cells and a polymer membrane. The present invention also relates to the use of this device as a bone graft and the manufacturing process of this device.

The invention discloses an injectable composite material for minimally invasive fracture fixation. The injectable composite material comprises the following raw materials: calcium sulfate bone meal, mussel mucin and a contrast agent. The method comprises the following steps: adding water into an injectable composite material, uniformly stirring, injecting into a fracture part, monitoring the filling condition of the composite material and the fracture reduction state in real time through the developing characteristic of the contrast agent in the injection process, and obtaining the streamer intramedullary nail after the composite material is solidified. According to the invention, the integration of biological fixation and repair is realized: the mussel adhesive protein provides a revolutionary biological bonding scheme, the bonding strength of the mussel adhesive protein is enough to stabilize a fracture end in an early stage, and the biocompatibility is excellent; calcium sulfate bone meal is used as a classic bone transplantation material, not only plays a role in filling and supporting, but also serves as a bone growth support (scaffold) to guide new bone tissue to grow in, finally complete biodegradation of the material and replacement of the material with new bone are achieved, and seamless connection from'artificial material fixation 'to'self bone healing' is completed.

Methods and systems are provided for using a machine learning system, such as an artificial neural network, with machine learning or deep learning recognition of clinical data patterns and correlations, with capabilities to integrate generative artificial intelligence, to determine the optimal bone grafting materials and procedures personalized to a patient and / or digital twin of a patient. In an embodiment describe herein, a representation of a location of a bone graft for a patient is accessed. A recommendation including an implant, one or more bone graft materials or biologics for the patient is generated based on applying a representation of the location of the bone graft and health data of the patient within a neural network. The recommendation is displayed at a provider user interface (UI) and / or patient UI.

Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.

The present invention discloses a minimally invasive bone harvesting device, which relates to the technical field of medical devices and includes: a cutting tool, the cutting tool includes a tubular tool body, a cutting edge is provided at the cutting end of the tool body, the cutting edge includes a first cutting edge and a second cutting edge, the first cutting edge is serrated, and the orientation of the first cutting edge is parallel to the axial direction of the tool body; the other end of the tool body is the second end, and the second cutting edge inclines towards the inner side of the tool body; a rotating collection bin, the second end is connected to one end of the rotating collection bin, and the bone tissue obtained by cutting with the cutting tool can move through the inside of the tool body into the rotating collection bin; a power component, the power component is used to drive the rotating collection bin and the cutting tool to rotate around the axis of the tool body. By designing the second cutting edge on the cutting tool, strip-shaped bone blocks can be obtained, and the power component drives the cutting tool and the rotating collection bin to rotate, so as to achieve the purpose of obtaining complete strip-shaped bone blocks in minimally invasive autologous bone transplantation surgery.

Methods and systems are provided for using a machine learning system, such as an artificial neural network, with machine learning or deep learning recognition of clinical data patterns and correlations, with capabilities to integrate generative artificial intelligence, to determine the optimal bone grafting materials and procedures personalized to a patient and / or digital twin of a patient. In an embodiment describe herein, a representation of a location of a bone graft for a patient is accessed. A recommendation including an implant, one or more bone graft materials or biologics for the patient is generated based on applying a representation of the location of the bone graft and health data of the patient within a neural network. The recommendation is displayed at a provider user interface (UI) and / or patient UI.