916 results about "Artificial skin" patented technology

The invention relates to compound millimicron fibrous membrane material of cellulose and cellulose matrix which can perform the biological degradation and the biological absorption and a preparation method thereof and an industry and medical purpose, and belongs to the biological macro-molecule non woven fabric material field which can perform the biological degradation and the biological absorption. Electrostatic spinning equipment is used to obtain the fibrous membrane material which can perform the biological degradation and the biological absorption, the weight of the cellulose is taken as basic reference, the component of the material comprises cellulose more than 0 and less than or equal to 100 weight parts, other biomacromolecule more than and equal to 0 and less than 100 weight parts, 0 to 10 weight parts of curative drug or 0 to 50 weight parts of inorganic catalyzer and / or 0 to 50 weight parts of inorganic strengthening agent. The material of the invention has good biological compatibility, biological degradation property and degradation absorptivity, and can be used for haemostasia material, wound cladding material, organization engineering supporting rack material, the transportation and release of medicine, artificial skin and blood vessel, and postoperation anti blocking material, beauty material and catalyzer carrier, filtering membrane and radiation protection material and so on.

An elastic strain sensor can be incorporated into an artificial skin that can sense flexing by the underlying support structure of the skin to detect and track motion of the support structure. The unidirectional elastic strain sensor can be formed by filling two or more channels in an elastic substrate material with a conductive liquid. At the ends of the channels, a loop port connects the channels to form a serpentine channel. The channels extend along the direction of strain and the loop portions have sufficiently large cross-sectional area in the direction transverse to the direction of strain that the sensor is unidirectional. The resistance is measured at the ends of the serpentine channel and can be used to determine the strain on the sensor. Additional channels can be added to increase the sensitivity of the sensor. The sensors can be stacked on top of each other to increase the sensitivity of the sensor. In other embodiments, two sensors oriented in different directions can be stacked on top of each other and bonded together to form a bidirectional sensor. A third sensor formed by in the shape of a spiral or concentric rings can be stacked on top and used to sense contact or pressure, forming a three dimensional sensor. The three dimensional sensor can be incorporated into an artificial skin to provide advanced sensing.

The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligaments, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fibers of collagen as its basic unit.

Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described. Fibers of desired porosity can be obtained from non-structural ECM by lyophilization and/or electrospinning which can be useful for numerous tissue engineering applications requiring complex scaffolds, such as wound healing, artificial skin (burns), soft tissue replacement/repair and spinal cord injury.

A ball and socket joint for implanting in the body is provided wherein the socket portion of the joint can have various orientations with respect to the patient's anatomy, and the orientation used for a particular patient can be selected and/or changed in situ, that is, during or after implantation of the joint. In addition, the configuration of the joint, e.g., constrained versus semi-constrained, as well as the materials making up the socket portion of the joint, e.g., plastic versus metal, can be selected and/or changed in situ. The questions raised in reexamination request Nos. 90/004,732, filed Aug. 26, 1997 and 90/005,596, filed Jun. 22, 1999, have been considered and the results are reflected in this reissue.

The present invention relates to a dermal substitute comprising the biodegradable polymer such as collagen and the biomaterial such as amnion, the preparation method and the use thereof. Specifically, the present invention provides with an amnion-collagen sponge complex structure prepared by attaching, inserting or incorporating an amnion obtained from placenta to/in collagen. Inventive dermal substitute can be applied to surgery and wound requiring skin graft, for example, severe burns such as second-degree burn, without rejection by immune system. Further, inventive dermal substitute with amnion instead of silicone membrane has several advantages, such as better biocompatibility, anti-inflammatory activity and promoting activity of wound healing and commercial utilization as basement membrane. Also, inventive complex structure can be used as the basic matrix of bio-artificial skin for culturing cells and the biodegradable basic matrix for preparing artificial organs.

The invention relates to an artificial hand controlled by myoelectric and brain, comprising myoelectric and brain electrode, myoelectric and brain signal treatment module, A/ D conversion data collection, myoelectric signal moving module identification and track prediction module, electrical artificial hand, touch and feel sensor, systematic feedback stimulation device, force and speed moderating module. The controlling method comprises following steps: collecting and enlarging myoelectric signal; collecting characteristic and identifying module; checking caught object condition, if the objection is not caught, a certain kind of physical stimulation signal will be sent to operator; checking brain information; outputting information to force and speed moderating module; output information controlling the electrical artificial hand. The invention overcomes limit of only taking myoelectric signal as signal source.

The invention discloses bio-medical engineering material and preparation method thereof, particularly relates to 3D tissue repair material suitable for adhesively growing of cell and preparation method thereof, belonging to bio-medical material technique domain. The natural tussah silk is used as raw material. After antheraea pernyi silk fibroin dissolves, 3D non-woven web structure composed of antheraea pernyi silk fibroin fibre is obtained by electrostatic spinning, wherein the fibre diameter is 50nm-20 mu m, the hole between the fibres is 1-500 mu m, the thickness of non-woven web is 50nm-20mm, and molecular weight of the antheraea pernyi silk fibroin is 10X10<4>-20X10<5>D. The bio-medical engineering material has features of non-poison, harmless, good biocampatibility, good adhesive growth ability of cell, etc. Because of the wide materials supply and low cost, the said material will replace some high-cost bio-medical material such as collagen, and will be used for repair material such as artificial skin, tendon, cartilage, duramater and so on, particularly for histiocyte induction material.

The invention relates to a method for preparing a nano-cellulose antibacterial composite material through on-line culture. The method comprises the following steps of: (1) inoculating an activated bacterial cellulose producing strain into a liquid culture medium, performing amplification culture, transferring the liquid culture medium into a bioreactor, culturing, adding an antibacterial material into the liquid culture medium, and continuing to culture to obtain an unpurified antibacterial bacterial cellulose composite material; and (2) peeling a bacterial cellulose membrane from a framework or directly soaking the composite material in a NaOH solution, treating in water bath, and washing until an obtained product is neutral to obtain the nano-cellulose antibacterial composite material. The preparation efficiency is high, and the method is simple, convenient, feasible and low in cost; and the surface of the bacterial cellulose composite material has a nanoscale three-dimensional fibrous mesh-shaped structure, the tensile strength of the material is greatly improved compared with that of a pure bacterial cellulose membrane, and the material can be widely applied to products such as facial masks, wound dressings, plasters, artificial skins and the like.

A nanometer superfine chitosan fibrous membrane material and its preparation process are disclosed. It belongs to tissue repair material technology. The film material with the diameter being 10 ª–mí½50ª–m, is made by chitosan with mass percent of 10-90% and polyvinyl alcohol or polyethylene oxide superfine fiber with diameter of 50nm -500nm The preparation process is: dissolving chitosan to acetic acid solution, adding PVA pr PEO into the solution, the mass ratio of chitosan with PVA/PEO being 10/90í½90/10, injecting the prepared 4%-8% spinning solution to the electrostatic spinning device for spinning to film material, therein, voltage being 5kVí½30kV, liquid inventory being 0.1mL/hí½0.5mL/h, receiving range being 5cmí½25cm. The advantages of the invention : large volume absorbing ability, favorable cell affinity, capable of degrading in vivo and promoting defect tissue repairing when the film material is utilized as artificial skin or artificial cartilage. In addition, the preparation process is simple.

The invention discloses a preparation method of a graphene oxide/bacterial cellulose antibacterial compound material. The preparation method comprises the following steps: (1) inoculating activated bacterial cellulose into a seed medium to culture, then, inoculating the activated bacterial cellulose into a fermentation medium according to an inoculum size of 5-10%, and after fully and uniformly mixing, putting in a constant-temperature culture box at 30+/-2 DEG C, standing and fermenting for 1-2 weeks to obtain a bacterial cellulose wet film; (2) after alkali-washing the bacterial cellulose wet film, pulping to a homogeneous phase suspension liquid by virtue of a mechanical method; (3) mixing a graphene oxide solution with the bacterial cellulose homogeneous phase suspension liquid, and carrying out ultrasonic dispersion to prepare a homogeneous phase mixed liquid; (4) decompressing and filtering the homogeneous phase mixed liquid, and freezing and drying to separate the graphene oxide/bacterial cellulose antibacterial compound material. The preparation method of the graphene oxide/bacterial cellulose antibacterial compound material disclosed by the invention is simple, few in step and easy to operate, and the prepared graphene oxide/bacterial cellulose antibacterial compound material has excellent antibacterial performance and can be widely applied to the fields such as medical dressing and artificial skins.

The invention discloses a method for preparing fibroin protein hydrogel, comprising the following steps: obtaining fibroin protein solution with mass concentration of 1-30% by degumming, dissolving and dialyzing domestic silkworm silk; carrying out ultrasonic oscillation treatment on the fibroin protein solution at the temperature of 0-60 DEG C with ultrasonic power being 10-2000 watt and treatment time being 30-600 seconds; carrying out standing for 0-6 hours, thus obtaining the fibroin protein hydrogel. With the method of ultrasonic oscillation treatment adopted, no chemical cross linking agent is added and the fibroin protein solution can be turned into the hydrogel in a short time, thus greatly improving work efficiency; meanwhile, the obtained fibroin protein hydrogel features good biocompatibility and adaptability to biological and medical fields such as artificial skin, artificial cartilage, cell culture brackets, bioreactors, enzyme immobilization materials and the like.

A system for removing perspiration from a residual limb inserted in a prosthesis comprising an nonporous prosthesis socket, a porous thin sheath adjacent the socket, a nonporous liner adjacent the sheath, an osmotic membrane adjacent the liner allowing water vapor to pass from the limb but preventing liquid from passing to the limb, a nonporous seal that prevents air leakage between the residual limb and the socket; and, a vacuum source to reduce the pressure in a space between the limb and socket. A method of removing perspiration from a residual limb in a prosthesis.

The invention discloses an artificial lens with an iris diaphragm, comprising an optical zone (1) which is transparent at the center, the iris diaphragm (2) surrounding the optical zone (1) and a loop (3); the artificial lens is in an integrated style and is composed of an entire block of material, the material is selected from foldable materials such as hydrophobic acrylic ester, hydrophilic acrylic ester, silica gel, etc. The artificial lens with the iris diaphragm of the invention has soft texture, can be filled or implanted in the eyes by a small incision after being folded; in addition, the artificial lens has high refractive index, thin lens, small incision and slow formation of after cataract and can slowly restore in 2-30 seconds after being implanted, thus cyst membrane is not easy to be damaged; moreover, the artificial lens has the advantages of little astigmia developed in post-operation, quick healing, fast recovery of visual performance and little postoperative treatment; a brown iris, which is the natural color iris of Chinese, can be adopted, and the eye implanted with such an artificial lens looks more natural.

The invention relates to a rehabilitation training system of amputation upper limb based on virtual reality, comprising the following parts: myoelectric signal detection and processing, amputation upper limb modeling and virtual reality scene interaction. The myoelectric signal detection and processing is realized by the steps of extracting, amplifying, filtering, A/D-transferring and multipath-acquiring myielectric signals on a stump by using a myoelectric tester ; extracting, extracting Rubust features of the myielectric signals and recognizing a fast and effective upper limb movement gesture together with an on-line learning method; the amputation upper limb modeling is realized by the steps of carrying out three-dimensional reconstruction on the amputation upper limb by adopting a three-dimensional parametric grid model and using a photo of a healthy upper limb, and realizing motion simulation of a virtual hand by taking the tracked upper limb movement parameters as model driven data; and the virtual reality scene interaction is realized by the steps of carrying out real three-dimensional interactional scene modeling and realizing real time interaction between the stump musclemovement and the three-dimensional scene through myoelectricity. The rehabilitation training system is mainly used to assist an upper limb amputated patient to carry out necessary adaptive training before installing an artificial limb so as to help the patient to adapt to the usage of the artificial limb as soon as possible.

The invention provides stretching conductive liquid metal particle based conductive ink and a preparation method and application thereof. The conductive ink comprises liquid metal and macromolecular solution. The conductive ink is simple in preparation, low in cost, easy in patterning and applicable to various substrate materials, and the liquid metal is intrinsically excellent in conductivity, flexibility and stretching performance. The conductive ink is nontoxic and harmless to human bodies and capable of fitting the human bodies without causing adverse effects, provides conditions for large-scale manufacturing of flexible stretchable printed circuit boards, provides conditions for large-scale manufacturing and application of wearable electronic equipment and can be used for developmentof various mechanical sensors and artificial skin.

The invention relates to a growth factor slow-release type double-layered artificial skin which is used for repairing injured skin with related growth factor slow-release functions and a preparation method thereof. The artificial skin is divided into two layers of an epidermal layer and an enderonic layer, wherein the epidermal layer is constituted by a micropore double-layered thin film with the functions of water proofing, ventilation and enderonic protection; the materials of the upper layer which contacts with air is polyurethane, or silicon rubber, or polyethylene glycol, or ethylene terephthalate and other medical materials; the lower layer which contacts with the dermis is a natural biological macromolecule thin film which is constructed by silk fibroin and chitosan; the enderonic layer of the artificial skin is constituted by collagen, polysaccharide and microspheres carrying growth factors related to skin regeneration and repairing; the microspheres have good slow-release function, and the slow-release period is equal to or slightly longer than the degradation period of the collagen and polysaccharide and can be matched with the skin regeneration and repairing period; and the thickness of the artificial skin is in a range of 0.5-1.5mm and can be regulated according to requirements.

An artificial bone comprising a calcium phosphate-based ceramic porous body having a plurality of pores which are three-dimensionally distributed throughout an entire region of the porous body including a surface thereof and have a diameter ranging from 0.01 μm to 2000 μm, and interconnecting portions which are formed between neighboring pores, interconnect a plurality of pores existing on a surface of the porous body.

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

The invention relates to artificial skin prepared from purely natural materials and having gradient hole structure and property and a preparation method thereof. The artificial skin comprises an epidermal layer and an enderonic layer, wherein the epidermal layer and the enderonic layer both have the gradient in the structure and the property simultaneously and the thicknesses of the epidermal layer and the enderonic layer are between 0.5 millimeters and 1.5 millimeters and can be regulated as required; the epidermal layer is a thin film which has the functions of water prevention, air permeation and enderon protection and has compacter structure, and the dimensions of holes are smaller than 5 micrometers; the epidermal layer has degradability, degrading period between four months and six months and good elasticity and ductility; the enderonic layer of the artificial skin is prepared from collagen and polysaccharide in a simulating way, in a sponge shape, porous and mutually communicated, the dimensions and the distribution of the holes are in gradient distribution from top to bottom, and apertures are increased from 20 micrometers to 300 micrometers; the enderonic layer has different degrading periods from top to bottom and is also in the gradient distribution, degrading speed is increased from top to bottom, and the degrading periods are accelerated from four months to two weeks; and the dimensions and the distribution of the holes and the gradient of degradation are controlled by the component transformation and a multi-layer overlying processing technology.

The invention relates to a nanometer silver gelatine nanometer fiber film, which comprises the following parts: a gelatine nanometer fiber and a nanometer silver distributed in gelatine nanometer fiber homogeneously, wherein the nanometer silver particle attaches the surface of the gelatine nanometer fiber or in the fiber, the mean diameter of the gelatine nanometer fiber is 60-220nm, and the mean diameter of the nanometer silver is 4-50nm. The electrostatic spinning method comprises the following steps: making the spinning liquid by adding silver nitrate in gelatin-formic acid solution; getting the nanometer fiber film with silver ion by electrostatic spinning; deacidizing the silver ion in the fiber into the nanometer silver particle with ultraviolet irradiation method. The nanometer silver gelatine nanometer fiber film is used to make the artificial skin, the medical dressing, the hemostatic material and the sanitary cotton.

The invention discloses a double-layer artificial skin and a preparation method thereof, wherein, cell-free membranous biological derivative material is used as a surface layer, and a fibroblast, extracellular matrix synthesized and secreted by the fibroblast and a cell growth factor are compounded in the interior of biological support material to form a dermis, and then the surface layer and the dermis are combined to form the double-layer artificial skin; a compact surface layer structure can effectively reduce the loss of water, electrolytes and protein from surface of wound, avoid the invading and the reproduction of bacteria to the impaired surface of wound as well as the infection of the surface of wound, and be beneficial to epitheliosis and epithelial growth; the dermis can directly repair the surface of wound, promote the ingrowth of cells around the surface of wound and the angiogenesis, induce the differentiation from stem cells to skin cells and quicken wound healing; the artificial skin has the advantages of being capable of promoting the regeneration of skin, improving the elasticity, the flexibility and the mechanical abrasion resistance of skin after the surface of wound is healed, reducing excess scar tissues, controlling the contracture, having excellent biocompatibility, increasing the success rate of transplant and improving the quality of healing; the double-layer artificial skin has wide material resources and simple production method, and is applicable to the clinical treatment of skin defect caused by inflammation, ulcer, thermal burns, iatrogenicity and the like.

The invention provides a tissue repair support and its preparation method and use. The tissue repair support comprises a porous tridimensional network structure composed of a composite fiber layer and a hydrophilic material. The composite fiber layer comprises composite fibers composed of an adhesion factor and a hydrophobic synthesis material. The tissue repair support is used for meninge repair, spinal meninge repair, a tissue engineering support material, artificial skin, a wound accessory material, a biomembrane, a wound cladding material, a haemostasis material, a postoperative antistick material or a beauty treatment material.