49 results about "Artificial skin" patented technology

The invention relates to artificial skin, in particular to self-generating full-layer artificial skin for wound treatment and application of the self-generating full-layer artificial skin. The artificial epidermis has an epidermis-dermis structure similar to skin, and the artificial epidermis structure is composed of an electrostatic spinning nano-film with piezoelectric capacity and has the functions of sterilization, protection and bioelectricity generation of an epidermis layer; the artificial dermal structure is composed of a photo-crosslinking polysaccharide and enzyme crosslinking protein interpenetrating hydrogel skeleton, by adding bioactive components and loading living cells, the effects of releasing active components and cytokines, remodeling wound extracellular matrix and promoting cell proliferation are achieved, and finally healing of acute and chronic wounds is remarkably accelerated. The invention provides a simple, feasible, economical and effective treatment method for sealing a large-area wound, sterilizing the wound and promoting healing of the wound.

The invention provides a preparation method of a composite artificial flap with a bionic structure and function induction activity. The preparation method comprises the following steps: S1, preparing an epidermis induction layer; s2, preparing a dermis functional remodeling layer; s3, preparation of a vascularization integration substrate layer; and S4, three-layer compounding and sterilization. Through an epidermis-basilar membrane-dermis three-layer integrated structure, a micron-nano multistage gradient pore and basilar membrane belt adhesion structure of natural skin is accurately simulated, and the problems of epidermis-dermis layering and non-uniform cell infiltration of an existing skin flap are solved.

The utility model relates to the field of medical instruments, in particular to a newborn artificial skin puncher with a hole diameter adjusting function, which comprises a base, a sliding seat is slidably connected to the upper end of the base, the sliding seat is driven by a driving component to move up and down, and a switching block is connected to the center in the sliding seat through a rotating rod. A cutting component is arranged on the periphery of the switching block in the circumferential direction, the bottom face of the sliding base is connected with a pressing plate through a buffering component, a through groove is formed in the lower portion of the base, a switching block is rotationally connected into the through groove, and cutting holes matched with the cutting component are formed in the periphery of the switching block in the circumferential direction. The device is provided with the switching block, the dividing column, the conversion block and the like, and effectively solves the problem that the aperture is inconvenient to adjust when the artificial skin of the newborn is manufactured at present.

The application discloses a hydrogel based on a mechanical interlocking principle, and a preparation method and application thereof. The hydrogel is composed of a flexible high polymer main chain and a rigid short side chain. The flexible high polymer main chain is used as the main body, and the rigid short side chain is added into the flexible high polymer chain as a mechanical interlocking unit. The super-strong, super-tough and crack growth resistant hydrogel material based on the mechanical interlocking structure can be applied to soft robots, artificial skin, flexible electronic devices, artificial tendons, cartilage repair and regeneration. The rigid polypeptide in the application has a single end connected with acrylic acid to provide an unsaturated carbon-carbon double bond for participating in copolymerization.

Disclosed are an artificial muscle module, artificial skin implementing a micro-expression, and a manufacturing method therefor. The artificial muscle module of the present invention comprises: an outer coil including a coiled outer yarn having a hollow; and an inner elastic body located inside the hollow and including an elastic body. Through the introduction of a tension supporter, free-standing is possible without an initial load, resulting in high utilization and enabling implementation of micro-emotional expressions.

The invention discloses a high-efficiency anti-infection double-layer artificial skin and a preparation method thereof. The high-efficiency anti-infection double-layer artificial skin has an excellent antibacterial effect and can reduce the occurrence of mucous membrane and instrument related infections. The collagen scaffold is a recombinant collagen scaffold with a three-dimensional pore structure, provides a suitable physical structure for cells, is beneficial to adhesion and proliferation of fibroblasts, vascular endothelial cells and the like, and has a remarkable skin wound repair effect. According to the invention, mTGase is mainly used for cross-linking glutamine and lysine sites to form protein-protein cross-linking; the Bis-PEG6-Acid can be used for cross-linking the Lys (Lys-NH2) and another protein, so as to form PEG (Polyethylene Glycol)-protein cross-linking; the mTGase and the Bis-PEG6-Acid do not directly and synergistically catalyze the same reaction site, a primary protein network is firstly constructed by the mTGase, the crosslinking density is further enhanced by the Bis-PEG6-Acid, a double-network structure is realized, and the mechanical strength, the degradation resistance and the hydrophilicity of the stent material are enhanced. And the hydrogel also has good tensile elasticity and biocompatibility, and is free of cytotoxicity and sensitization.

This invention belongs to the field of biomedical materials, specifically providing a highly permeable hydrophilic polyurethane artificial membrane based on chemical grafting and its preparation method, comprising the following steps: S1 - Substrate pretreatment: Immersing a polyurethane film in an organic solvent, ultrasonically cleaning and soaking for 0.5-2 hours, then removing and drying to constant weight to obtain a pretreated substrate; S2 - Preparation of hydrophilic modified polyurethane: Completely immersing the substrate obtained in step S1 in a hydrophilic modification solution, introducing an inert gas for 10-30 minutes, heating to 35-45°C, and reacting under stirring or shaking in the dark for 6-24 hours to obtain a hydrophilic modified polyurethane membrane; S3 - Post-treatment: The hydrophilic modified polyurethane membrane from step S2 is sequentially acid-washed, water-washed, and then vacuum-dried to obtain the hydrophilic polyurethane artificial membrane. The hydrophilic polyurethane artificial membrane of this invention, prepared by chemical grafting, possesses high permeability and excellent mechanical properties.

1. The name of the design product: insulin injection simulation artificial skin. 2. The use of the design product: the product is mainly used to demonstrate injection site selection and injection process in subcutaneous injection education process. 3. The design points of the design product: the combination of shape, pattern and color. 4. The picture or photo that best indicates the design points: perspective view. 5. The design for which protection is sought contains color. 6. The back of the design product is a part that is not easy to see or cannot be seen during use, and the rear view is omitted.

This utility model discloses a quantitative measuring device for evaluating the stickiness of cosmetics, belonging to the field of cosmetic testing technology. It includes a fixing component, a telescopic component, a measuring component, a pressure block, and test skin. The fixing component includes a base and a column; the base is placed on a working surface; the column is mounted on the base; the telescopic component is mounted on the base; the measuring component includes a connector and a force sensor; the force sensor is mounted on the column; the connector is connected to the force sensor; the test skin includes a first skin and a second skin, which are in contact with each other; the pressure block is used to enhance the contact between the first and second skins; the first skin is mounted on the telescopic component, and the second skin is connected to the connector. This utility model uses artificial skin to simulate the contact and separation process of skin, making operation simple and reducing the influence of subjective factors and external environment on the evaluation results; by measuring the force during the skin separation process through the force sensor, it achieves intuitive quantitative evaluation.

The invention provides antibacterial hydrogel artificial skin and a preparation method thereof, and belongs to the technical field of 3D printing biomaterials, the antibacterial hydrogel artificial skin is prepared from the following raw materials by weight: 1-3 parts of aluminum chloride hexahydrate, 30-45 parts of water, 15-22 parts of graft modified chitosan, 8-15 parts of acrylamide, and 1-3 parts of N, N-dimethylformamide. The coating comprises the following components in parts by weight: 0.2-0.8 part of N, N '-methylene bisacrylamide, 0.5-1.5 parts of a photoinitiator, 6-12 parts of quaternized chitosan and 4-8 parts of nano-hydroxyapatite. Wherein the graft modified chitosan is prepared from the following raw materials: 5 to 10 parts of chitosan, 80 to 120 parts of acetic acid solution with the concentration of 2 percent, 0.8 to 2.5 parts of glycidyl methacrylate and 0.05 to 0.2 part of azodiisobutyronitrile. According to the application, by adopting a formula taking the grafted modified chitosan as a core, a collaborative design of multi-scale crosslinking and personalized 3D printing is formed, high mechanical strength, broad-spectrum long-acting bacteriostasis, precise form adaptation and excellent biocompatibility of the hydrogel are realized, and the clinical complex wound repair requirements are met.

The invention provides a polarization imaging-based automatic detection method for preventing cheating of a camouflage mask. The method comprises the following steps of: acquiring and constructing data; preprocessing and labeling the data; training a preset model; calculating a detection frame coordinate, a category label and a confidence coefficient; and defining a camouflage tendency value according to the category label and the confidence coefficient, and judging the authenticity of the detected target according to the camouflage tendency value and a preset judgment threshold value. According to the method, the polarization reflection characteristics are utilized to construct the face surface polarization characteristics, and the distinguishability of different materials (such as silica gel, artificial skin and three-dimensional printing materials) in the microstructure and the reflection mode is enhanced by calculating the linear polarization degree and the polarization angle and carrying out energy weighted fusion.

Disclosed is an artificial adipose tissue comprising a three-dimensional tissue comprising: a population of cells including an adipocyte; and a fragmented extracellular matrix.

The present application relates to the technical field of biomedical materials, in particular to a super-elastic hydrogel material, a super-elastic injectable scaffold and a preparation method and application thereof. The super-elastic hydrogel material is obtained by cross-linking a base material with an initiator; the base material comprises GelMA and PEGDA with a molecular weight of 2000-20000; the injectable scaffold comprises a three-dimensional structure scaffold composed of super-elastic material, which can restore the original shape after being compressed and injected. The present application utilizes the excellent mechanical properties and shape memory of super-elastic material to realize solid injection and restore the original shape after injection, thereby providing a new idea and approach for large-size injectable scaffolds. The scaffold of the present application can be used in the fields of tissue engineering and regenerative medicine, minimally invasive injection transplantation, artificial skin, myocardial patch, in-vitro engineered tissue model construction, tissue physiological function remodeling and pathological process mechanism research, mechanical regulation and stress regulation mechanism research, drug development and drug screening, etc.

The application discloses a multifunctional gradient structure artificial skin and a preparation method and application thereof, and belongs to the technical field of biomaterials and biomedical engineering. The upper layer of the application is a silica gel layer, which is used for simulating epidermis to keep a moist environment of a wound and simultaneously plays a barrier role; the intermediate layer is a degradable polymer / natural bioactive protein composite layer, which is used for enhancing mechanical properties; and the lower layer is a hydrogel layer, which is formed by cross-linking hyaluronic acid and carboxymethyl chitosan to form a Schiff base bond and then cross-linking collagen through catalysis. The composition of the hydrogel layer is a component of an extracellular matrix, and the three-dimensional network structure formed is beneficial to cell growth, can simulate a dermis layer to play a function of promoting tissue regeneration and remodeling, and finally the artificial skin with good mechanical strength, capable of preventing wound infection and promoting wound healing is obtained.

The application discloses a kind of based on artificial leather's leakage testing device for indwelling needle, it is related to the leakage testing field of indwelling needle, including base, the top of base is rotatably connected with carousel, carousel top is equipped with device body, the center of device body top is equipped with leakage testing assembly, the top of leakage testing assembly is equipped with mounting column, mounting column outer wall is equipped with air bag, the top of leakage testing assembly is provided with artificial leather displacement assembly, one end of artificial leather displacement assembly is rotatably connected with cam, the bottom of artificial leather displacement assembly is movably connected with artificial leather, and the top of artificial leather is equipped with connecting column.The leakage testing device for indwining needle based on artificial leather of the application, by integrating automation flow, pneumatic seal, bionic material fitting, precision mechanical transmission and sensing monitoring technology, traditional inefficient, inaccurate manual leak detection method is successfully replaced, can effectively improve the efficiency, accuracy, consistency, health standard and of indwining needle leak detection.

The invention provides a multilayer artificial skin flap containing a built-in nutritional blood vessel and a preparation method of the multilayer artificial skin flap, and belongs to the technical field of tissue engineering and regenerative medicine. The artificial skin flap is sequentially provided with a first decellularized meat pulp matrix layer, a nutritional blood vessel, a fabric layer and a second decellularized meat pulp matrix layer from top to bottom. The nutrition blood vessel can construct a nutrition delivery channel for surrounding tissues, and promote rapid proliferation of cells and formation of a new blood vessel network; the decellularized meat pulp matrix layer provides a bionic microenvironment and supports cell adhesion, migration and growth; the fabric layer plays a role in enhancing mechanical support and simultaneously endows the flap with good stitchability and tear resistance; in addition, the nutritional blood vessel and the fabric layer are both made of degradable filaments, the degradation period can be regulated and controlled according to needs, and space and mechanical support smooth transition is vacated for tissue growth. The artificial skin flap has excellent biocompatibility, controllable degradability, active vascularization ability and proper mechanical properties, and is suitable for full-thickness skin defect repair and soft tissue regeneration engineering.

This invention provides a highly efficient transdermal small molecular weight recombinant transdermal human elastin, its preparation method, and its applications, belonging to the fields of genetic engineering and biomaterials technology. The amino acid sequence of the elastin is derived from human elastin, with a His tag at its N-terminus for purification, and a TD1 transdermal peptide fused to its C-terminus to enhance transdermal delivery. The elastin is prepared through expression in genetically engineered bacteria, has a small molecular weight, and possesses a typical β-helical hydrophobic domain, exhibiting excellent biomimetic structure and functional properties. The small molecular weight recombinant transdermal human elastin demonstrates high transdermal efficiency and excellent biocompatibility, and can be widely used in skin repair dressings, implants, artificial skin, biomedical materials, and functional skincare products. Furthermore, the elastin exhibits good solubility, high stability, and a mature expression system, making it suitable for large-scale production.

The invention discloses a preparation method of exosome-loaded enzyme response type sandwich bionic artificial skin and application of the exosome-loaded enzyme response type sandwich bionic artificial skin in diabetic wounds. According to the prepared enzyme response type bionic artificial skin, hypoxia exosomes prepared from hypoxia stimulated cells are loaded through a fiber membrane; the engineering exosome of the high-load chemotactic factor CCL-2 is prepared by self-assembled polypeptide gel loading and inflammatory factor stimulation, and the two exosomes are combined to regulate and control the immune microenvironment of the diabetic wound surface so as to better promote the healing of the diabetic wound surface.

The present disclosure provides a care device with improved pleasantness when the care device is brought into contact with and worn on the skin. The care device of the present disclosure is a care device that is brought into contact with or worn on the skin. The care device of the present disclosure includes a skin wearing member containing an elastomer. The skin wearing member has an Asker C hardness of 30 degrees or less and a coefficient of static friction of 3 or less. Here, the coefficient of static friction is a coefficient of static friction for an artificial skin sheet that satisfies the following characteristics (A) and (B). (A) A compressive stress of the artificial skin sheet at a time of being pushed in a thickness direction at a depth of 2 mm is between 0.01 MPa and 0.05 MPa inclusive. (B) Calculated average roughness Ra of a surface of the artificial skin sheet is from 5 μm to 10 μm.

The application belongs to the technical field of bionic skin material preparation, and specifically provides a silicone and water-based polyurethane composite bionic skin material and a preparation method thereof. The material is prepared by compounding a water-based polyurethane synthetic leather, human silicone and a conductive fiber cloth base. The water-based polyurethane material of the epidermis gives the material the touch of baby skin; the middle silicone material acts as a muscle layer, ensuring that the overall material has a soft and elastic meat feeling; the conductive fiber cloth at the lowermost layer can not only act as a heating system, but also provide a linkage between the skin and the core control mechanism of the robot as a wire. This process not only solves the problem of low surface energy of silicone and difficulty in gluing, but also retains the soft and elastic meat feeling of silicone and gives it the touch of baby skin. The material has the advantages of baby skin touch, high strength and good durability, so the flexible robot skin material will have a broad application prospect in the fields of artificial skin, soft robot, wearable device, soft toy and prosthesis epidermis.

The present application relates to the field of biological materials, in particular to a high-efficiency transdermal recombinant humanized elastin as well as a preparation method and application thereof. In view of the problem that macromolecular drugs and proteins are difficult to be effectively absorbed through skin in the prior art, the present application discloses a high-efficiency transdermal recombinant humanized elastin, a coding gene, a recombinant vector, a recombinant genetically engineered bacterium, and a preparation method and application thereof. The protein has cell penetration ability and transdermal ability, and is obtained by protease cleavage from a precursor elastin. The nucleotide sequence of the coding gene of the precursor elastin is a sequence shown in SEQ ID NO. 3 or an equivalent sequence. The recombinant humanized elastin of the present application can be applied to skin care products, dressings, implants, artificial skin, artificial blood vessels, medical devices, biological materials or functional foods, and is particularly suitable for external preparations for anti-wrinkle, anti-aging or skin barrier repair.

The invention discloses a test method and device for simulating artificial skin sweat corrosion. Comprising the following steps: step 1, preparing a sample; step 2, preparing a mask of the artificial skin: cutting and hollowing on a metal surface by using laser according to a specific shape to prepare the mask; 3, preparation of an artificial skin membrane layer: covering the fiber wicking base material with a mask of the artificial skin, and spraying the surface of the fiber wicking base material by a spraying method to prepare the artificial skin membrane layer; 4, setting a test environment: sequentially connecting and assembling a liquid storage device, a corrosive medium quantitative delivery pump, a corrosive medium input pipe, a bottom hydrophilic fiber film layer and the artificial skin, and placing the assembled materials in the test environment, wherein the reverse side of the artificial skin is in contact with the hydrophilic fiber film; placing the sample on the front surface of the artificial skin; and 5, introducing the artificial sweat. The actual sweating state of the human skin can be accurately simulated, and the problem that a traditional total immersion method does not conform to the actual wearing environment is solved.

The invention belongs to the technical field of simulation skin, and particularly relates to robot simulation skin and a preparation method thereof. Raw materials: an elastomer matrix; a base oil agent; a polyolefin; a compatilizer; rubber; a temperature-sensitive auxiliary agent; a photosensitive auxiliary agent; conductive particles; an antioxidant; and other auxiliary agents. The preparation method comprises the following steps: quickly stirring, rubbing and heating the elastomer matrix, adding the base oil agent, filling oil, premixing with polyolefin, putting into an extruder, adding the rubber and the compatilizer, extruding, granulating, adding the temperature-sensitive additive, the light-sensitive additive, the conductive particles and the antioxidant under a dark condition, and continuously stirring; adding other auxiliary agents, and uniformly dispersing; the mixed composite material is subjected to calendaring molding or injection molding or tape casting, and the robot simulation skin is obtained. The skin prepared by the invention has basic mechanical properties and environmental response capability, and can give consideration to both softness and durability.

The invention discloses a moisturizing simulation artificial skin and a manufacturing method, and relates to the technical field of biomedical engineering. The method comprises corium layer construction, epidermal layer construction and double-layer simulated human skin construction. The method comprises the following steps: S1, corium layer construction: carrying out resuspension counting on human fibroblasts in a fibroblast culture solution; the trehalose and the silk fibroin are used as a composite moisturizing system to be introduced into a collagen-hyaluronic acid matrix and cell culture environment, in the gelation process and the cell metabolism activity, all components form a stable three-dimensional network structure through intermolecular interaction, the network can dynamically anchor water molecules, and the water molecules in the three-dimensional network structure can be effectively inhibited. According to the invention, continuous regulation and slow release of moisture are realized, so that a microenvironment suitable for wetting is established and maintained on the wound surface, the application value of the artificial skin in pediatric burn treatment is effectively improved by the mechanism, and the artificial skin is especially suitable for high-exudative wound surfaces and effectively promotes epithelial cell migration and wound surface healing processes.

The present application relates to a kind of newborn artificial skin cutting device, belong to medical instrument field.The present application includes: base, force pressing rod, hinged mechanism, down pressure rod, multiple blades, adjusting mechanism, support mechanism, protection mechanism, column and blade reset mechanism;Column is vertically connected with one end of base, column is connected with force pressing rod by hinged mechanism, support mechanism is vertically installed on column, and is set above base, protection mechanism is installed on support mechanism, down pressure rod is vertically set, and is connected with force pressing rod by hinged mechanism, adjusting mechanism is connected with the bottom end of down pressure rod, and passes through support mechanism and protection mechanism, blade is vertically set between the base of adjusting mechanism, and can be displaced and pass through support mechanism, blade reset mechanism is set on blade, and is connected with support mechanism.The present application is favorable to improve cutting convenience and efficiency, most importantly, to reduce the pain of sick children, reduce iatrogenic skin damage.

The application discloses a semi-biosynthetic fur and a preparation method thereof, and the preparation method of the semi-biosynthetic fur comprises S1) obtaining of hair, S2) preparation of a hair bundle, S3) integration and culture of a tissue sheath, S4) synthesis of epidermal cells and S5) combination of fur. In one aspect, the required pinna and down are obtained from animals in a painless and sustainable manner by combing the hair and are composed into a hair bundle, and in the other aspect, stem cells are extracted from the blood of animals and induced pluripotent stem cells are cultivated to differentiate into required cells and tissues to form an artificial skin layer, finally, the hair bundle can be embedded into the artificial skin layer by means of biological bonding and semi-biosynthetic fur is formed, the prepared semi-biosynthetic fur is almost the same as natural fur in performance bionics and the like, compared with traditional artificial fur, the semi-biosynthetic fur is extremely small in environmental ecological pollution, and the semi-biosynthetic fur can reduce animal killing and maintain the rights and interests of employees in the original industry such as animal breeders.

The application belongs to the technical field of bionic skin material preparation, and specifically provides a TPE water-based polyurethane type bionic robot skin material and a preparation method thereof. The bionic skin material is composed of a water-based polyurethane synthetic leather skin layer, a thermoplastic elastomer TPE layer (foamed TPE layer) and a heating film. The epidermal water-based polyurethane material provides a baby skin touch, the middle layer TPE provides a soft and elastic meat feeling, and the lowermost layer heating film can endow the bionic skin material with a warm feeling. The bionic skin material preparation method of the application adopts a hot pressing process, solves the difficulty that the TPE surface energy is low and cannot be glued, and does not change the soft and elastic hand feeling of the TPE; the hot-pressed water-based polyurethane synthetic leather solves the problems that the traditional TPE material is prone to oil penetration and has an odor; the middle layer can adopt foamed TPE, and the lightweight function of the material can be realized; and the bionic skin material has a wide application prospect in the fields of artificial skin, soft robot, wearable device, soft toy and artificial limb skin, etc.

The invention relates to a method for analyzing the transdermal permeation content and distribution of cosmetic active ingredients, which comprises the following steps: smearing the cosmetic containing the active ingredients on artificial skin for permeation treatment, and freezing and slicing to obtain a sample; the method comprises the following steps: acquiring data by adopting a desorption electrospray ionization mass spectrometry imaging technology, and extracting a peak table containing position, mass-to-charge ratio and intensity information; performing normalization processing on the target object intensity of each pixel point by taking the mass locking internal standard object as a reference to generate a normalized mass spectrum imaging graph; identifying a skin tissue area by using the endogenous characteristic substance signal distribution of the skin and adopting an image segmentation algorithm; the average normalized intensity of the target object in the area is calculated to quantify the permeability content difference, and the distribution uniformity is evaluated through a variable coefficient. Compared with the prior art, the method can accurately quantify the content change of the target object under different conditions, and supports the relative content analysis and distribution uniformity analysis of the target object in the data acquired within the day and during the day in a long range.

To provide a culture insert container that will improve yield and eliminate various operations requiring proficiency, and dramatically increase production efficiency, and permit reduction in the amount of fibroblast cells that are used, without requiring an operation in which a piece is cut out therefrom, and to provide a method for producing tension-applied three-dimensional artificial skin employing same, a culture insert container having a lower culture container having a bottom portion equipped with a porous membrane and a sidewall, and having an upper insertion fixture having a cylindrical sidewall that is inserted into said lower culture container, said cylindrical sidewall having a land arranged so as to protrude from a top end of the sidewall of the lower culture container at a location such as will cause a top surface of said porous membrane and a bottom end portion of said cylindrical sidewall which is inserted within the lower culture container to be maintained in a noncontacting state, and having a land arranged at an outer surface of the cylindrical sidewall so as to cause a constant distance to be maintained between an inner surface of the sidewall of the lower culture container and the outer surface of the cylindrical sidewall, is employed.