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Tissue repair support and its preparation method and use

A tissue repair and composite fiber technology, applied in the field of biomedical devices and their preparation, can solve the problems of foreign matter and immune response, no porous structure, difficult tissue compliance and adhesion, etc., and achieve high porosity and specific surface area, Good compatibility and fit, good restorative effect

Active Publication Date: 2015-12-30
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the defects of the existing materials and their pore structures, they are very different from the constituent units of human tissue, especially the hydrophobic synthetic materials adopt the general preparation method, and there is basically no good porous material similar to the extracellular matrix. structure, it is difficult to conform to the characteristics of tissue anatomy, and it is difficult to form good tissue compliance and adhesion with tissue anatomy
[0004] Woven mesh is currently the most widely used product in tissue repair fiber membranes, but this type of product often has the following problems: 1) The surface is rough, the texture is relatively hard, and the tissue compliance is poor. The friction of the material will give the patient a great degree of discomfort, and it is easy to produce foreign body sensation and pain, causing common erosion and infection and other complications; There are many surgical sequelae; when it is in direct contact with internal organs and organs, it is easy to cause damage, which can cause serious adhesions, severe foreign bodies and immune reactions, and requires a second operation to remove it, which brings pain to the patient and even endangers life.
The current electrospun membranes are often found to be difficult or slow for cells to grow into the interior
The performance of fiber membranes for tissue repair formed by existing weaving and electrospinning technologies is not ideal

Method used

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  • Tissue repair support and its preparation method and use
  • Tissue repair support and its preparation method and use
  • Tissue repair support and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] PCL and collagen are dissolved in hexafluoroisopropanol according to a mass ratio of 4:1 to form a solution with a total concentration of 8% by mass, and then the solution enters the centrifugal spinning machine through a propulsion pump, and the propulsion speed of the propulsion pump is 150g / min. The linear speed of the centrifugal disk is 6000m / min, the solution is spun into fibers rapidly, the spinning temperature is 50°C, after the end, the membrane is removed from the receiver, and then the residual solvent in the membrane is removed to obtain a composite fiber membrane (referred to as material A) . The obtained composite fiber membrane was soaked in 2% by mass gelatin aqueous solution for 5 min, and then freeze-dried to prepare a tissue repair scaffold (referred to as material B).

Embodiment 2

[0088] Dissolve PLLA and gelatin in hexafluoroisopropanol at a mass ratio of 2:1 to form a solution with a total concentration of 8% by mass, then fill the above solution into an electrospinning syringe, and adjust the speed of the microsyringe pump to 4 ml / Hours, adjust the voltage of the high-voltage generator to 23kV, and adjust the receiving distance of the receiving device to 19 cm. The receiving device uses a rotating roller, the moving speed of the electrospinning needle is 15 cm / s, the rotating speed of the receiving roller is 120 cycles / min, and the two needles are electrospun simultaneously for 8 hours. After the end, the film was removed from the receiving roller, and then the residual solvent in the film was removed, soaked in an aqueous solution of 7% by mass gelatin for 30 minutes, and then freeze-dried to prepare tissue repair scaffold E.

Embodiment 3

[0090] PLGA and chondroitin sulfate were dissolved in trifluoroacetic acid at a mass ratio of 4:1 to form a solution with a total concentration of 8% by mass, then the above solution was loaded into an electrospinning syringe, and the rate of the microinjection pump was adjusted to 5 ml / Hours, adjust the voltage of the high-voltage generator to 24kV, and adjust the receiving distance of the receiving device to 19 cm. The receiving device uses a rotating roller, the moving speed of the electrospinning needle is 10 cm / s, the rotating speed of the receiving roller is 150 cycles / min, and the two needles are electrospun at the same time for 8 hours. After the end, the membrane was removed from the receiving roller, and then the residual solvent in the membrane was removed, soaked in an aqueous solution of 2 mass % gelatin for 10 min, and then freeze-dried to prepare a tissue repair scaffold.

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Abstract

The invention provides a tissue repair support and its preparation method and use. The tissue repair support comprises a porous tridimensional network structure composed of a composite fiber layer and a hydrophilic material. The composite fiber layer comprises composite fibers composed of an adhesion factor and a hydrophobic synthesis material. The tissue repair support is used for meninge repair, spinal meninge repair, a tissue engineering support material, artificial skin, a wound accessory material, a biomembrane, a wound cladding material, a haemostasis material, a postoperative antistick material or a beauty treatment material.

Description

technical field [0001] The invention relates to a biomedical device and its preparation, in particular to a tissue repair bracket, its preparation method and application. Background technique [0002] Tissue repair scaffolds are very common in clinical work, such as tendon repair, ligament repair, hernia repair, dura mater repair, female pelvic floor dysfunction disease repair, blood vessel repair, sling repair, skin repair, fistula repair , Nerve conduit repair, bone defect repair. [0003] Due to the defects of the existing materials and their pore structures, they are very different from the constituent units of human tissue, especially the hydrophobic synthetic materials adopt the general preparation method, and there is basically no good porous material similar to the extracellular matrix. It is difficult to conform to the characteristics of the anatomical structure of the tissue, and it is difficult to form good tissue compliance and adhesion with the anatomical struc...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/56A61L27/58A61L27/60A61L15/26A61L31/12
Inventor 杨亚亚邓坤学徐弢袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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