14 results about "Electrospun membranes" patented technology

This invention relates to the field of electrospun membranes, and more specifically to a one-step photocurable electrospun membrane material and its preparation method. The photocurable electrospun membrane material is prepared by mixing 5-20 parts of fiber-forming macromolecules, 10-40 parts of collagen, 0.05-3 parts of natural photosensitizer, and a solvent to form a spinning solution. Electrospinning is performed using either needle-type or non-needle-type methods. Simultaneously, the fibers are irradiated with 200-400 nm ultraviolet light in situ to achieve photocuring and cross-linking, thus obtaining a micro / nanofiber membrane in one step. The fiber-forming macromolecules are selected from biodegradable medical polymers, and the photosensitizers are biosafe components such as riboflavin and retinaldehyde. This invention completely solves the problems of uneven cross-linking, fiber morphology damage, collagen denaturation, and internal light filtering effects in traditional two-step methods. The resulting membrane has regular fiber morphology, uniform cross-linking, high mechanical strength, good water resistance, and complete retention of bioactivity. Furthermore, the process is simplified, complies with pharmaceutical quality management standards, and is suitable for medical applications such as tissue engineering and wound repair.

This invention provides a temperature and humidity responsive actuator and its preparation method. The actuator is a double-layer electrospun film actuator, composed of a sequentially electrospun polyacrylonitrile (PAN) fiber layer and a poly(N-isopropylacrylamide) (PNIPAM) fiber layer. This invention introduces electrospinning technology into the preparation of the actuator, selecting temperature-inert polyacrylonitrile (PAN) and temperature-sensitive poly(N-isopropylacrylamide) (PNIPAM) as the polymers for sequential electrospinning. Through a simple preparation process, an actuator with good temperature and humidity responsiveness can be efficiently prepared, and the prepared actuator exhibits high sensitivity, fast temperature and humidity response speed, and stable performance.

The invention discloses a curcumin-strontium nanoparticle loaded silk fibroin / polycaprolactone electrospun membrane and a preparation method and application thereof, the preparation method comprises the following steps: S1, dissolving a strontium source compound in a polyvinylpyrrolidone solution, adding curcumin, and continuously stirring to obtain a curcumin-strontium solution; s2, dialyzing the curcumin-strontium solution, and washing and drying a product to obtain curcumin-strontium nanoparticles; s3, dissolving the curcumin-strontium nanoparticles in a spinning dispersant, and adding silk fibroin and polycaprolactone to obtain a spinning solution; and S4, carrying out electrostatic spinning on the spinning solution to obtain the silk fibroin / polycaprolactone electrospun membrane loaded with the curcumin-strontium nanoparticles. According to the invention, natural polyphenol compound curcumin and strontium ions are coordinated to synthesize curcumin-strontium nanoparticles, and the curcumin-strontium nanoparticle loaded silk fibroin / polycaprolactone electrospun membrane is constructed in combination with an electrostatic spinning process. The electrospun membrane has good surface morphology, appropriate degradation rate and excellent mechanical strength, and can synergistically promote osteogenic differentiation of jaw bone marrow mesenchymal stem cells.

This invention discloses a three-layered functional hydrogel material for osteochondral repair that promotes chondrogenesis through traditional Chinese medicine and physical stimulation, and its preparation method. Specifically, the method includes: 1) preparing a PCL electrospun membrane using electrospinning technology, and forming an HA coating on its surface using a hydrothermal method with biomimetic mineralization; 2) constructing the HA coating on the surface of black phosphorus sheets and preparing cryptotanshinone nanopowder using in-situ mineralization and spraying methods, and mixing it with BMSCs in a porous GelMA solution; 3) preparing MCSN nanoparticles loaded with baicalein using a hydrothermal template method and ultrasonic impregnation process; 4) dispersing barium titanate nanowires, drug-loaded MCSN, and BMSCs in a SilMA / HAMA solution; 5) pouring the GelMA mixture into a mold and pre-curing it, placing a plasma-treated mineralized electrospun membrane on top, then pouring the SilMA / HAMA mixture and completely curing it to obtain the desired hydrogel. This composite material has a three-layer structure, matching the needs of osteochondral repair.

The application discloses a kind of gold nanometer double-cone functionalized electrospun fiber membrane and its preparation method and visual analysis application, the application is by gold nanometer double-cone load in the surface of electrospun fiber membrane and mobile phone chroma identification technology two combinations, finally develops a kind of acetylcholinesterase and its inhibitor visual POCT technology;The functionalized electrospun membrane overcomes the defect that the quantitative effect of vision is not good in the single color of visual effect, the resolution is not high in traditional visual equipment, shows higher level in the quantitative and qualitative analysis detection of acetylcholinesterase, with good visual signal effect, high sensitivity, good reproducibility, multicolor high efficiency and the like advantages.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a DFO@GMs-pDA / PN composite scaffold for promoting vascularization and osteogenesis, and a preparation method and application thereof. The DFO@GMs-pDA / PN composite scaffold for promoting vascularization and osteogenesis is constructed by using electrospinning, pDA modification and emulsification-extraction technology, and by wrapping DFO into GMs and loading the DFO into a pDA surface modified PN electrospinning film. The most superficial DFO@GMs begin to disintegrate and release DFO after implantation, and the maximum drug release rate is reached after 48 hours, so as to promote the ingrowth of new blood vessels, the recruitment of stem cells and the secretion and presentation of related factors in the early stage of bone regeneration, and to provide an important blood supply basis for bone regeneration.

The invention discloses a preparation method and application of a modified electrospun nanofiber scaffold material. The method comprises the following steps: dissolving PLGA (poly (lactic-co-glycolic acid)) and PCL (polycaprolactone)) in an organic solvent, dissolving chitosan, adding the dissolved chitosan into the solution, obtaining a PP / CS (polypropylene / CS) substrate membrane by using an electrostatic spinning method, adding the substrate membrane into a PBS (phosphate buffer solution), and stirring to obtain homogenate; respectively preparing a genipin solution and a gelatin solution as a main cross-linking agent and an auxiliary cross-linking agent; and sequentially adding a gelatin solution and a genipin solution into the obtained homogenate, fully stirring and mixing, putting into a forming template, and freeze-drying to obtain the scaffold material. According to the invention, a polylactic acid-glycolic acid copolymer / polycaprolactone composite electrospun membrane is used as a substrate, chitosan is used as an active component, fiber fragments are obtained through mechanical crushing, and genipin and gelatin are used as biological cross-linking agents for structural recombination. The scaffold material prepared by the method has excellent mechanical properties and biocompatibility, and is suitable for the field of bone defect repair.

This invention discloses a high-performance nano-electrospun membrane and its preparation method. The electrospinning solution of the nano-electrospun membrane comprises a synergistically modified polymer matrix material, an organic small molecule, polyethylene glycol, polyvinylpyrrolidone, Tween-80, zinc stearate, and a solvent. The synergistically modified polymer matrix material is based on polyacrylonitrile, and is prepared by introducing dopamine, 3,4-dihydroxyphenylethylamine hydrochloride, 3-aminopropyltriethoxysilane, and cerium nitrate in solution. The organic small molecule is propyl gallate. Through the synergistic effect of the components, the prepared nano-electrospun membrane exhibits high continuous film-forming stability, good structure retention during use, excellent environmental stability, and outstanding storage and reuse performance of the electrospinning solution. The method of this invention is stable, highly feasible, and suitable for the preparation and application of high-performance nano-electrospun membranes.

The present application belongs to the technical field of biological materials, and particularly relates to a pharmaceutical composition, an electrospun membrane and a preparation method and application thereof. The pharmaceutical composition comprises at least dexamethasone and deferoxamine. The pharmaceutical composition of the present application can promote HUVECs angiogenesis and BMSCs osteogenic differentiation in vitro, has the ability to promote vascularized bone regeneration in vivo, and is further verified through the Wnt / β-catenin signaling pathway that the pharmaceutical composition formed by dexamethasone and deferoxamine can play an obvious synergistic effect of promoting vascularized bone regeneration. The present application further provides an electrospun membrane, which uses coaxial electrospinning technology to load the small molecule drug deferoxamine (DFO) for promoting angiogenesis in the fiber shell layer, and load dexamethasone (DEX) for promoting osteogenic differentiation in the fiber core layer, so as to realize the programmed drug release behavior of early rapid release of DFO in the shell layer and sustained long-acting release of DEX in the core layer, and the effect of vascularized bone regeneration is obvious.

The application relates to a preparation method of a modified cellulose acetate electrospun membrane, which comprises the following steps: mixing N,N-dimethylacetamide and acetone in a certain proportion, adding cellulose acetate into the transparent solution, and fully stirring to obtain a mixed solution; adding a certain amount of eggshell membrane powder into the mixed solution, fully stirring to obtain a spinning stock solution; adopting an electrospinning technology to obtain a cellulose acetate electrospun membrane; and after deacetylation treatment, washing and drying, a modified cellulose acetate electrospun membrane is obtained. The preparation method is simple, the steps are easy to operate, the prepared electrospun membrane has excellent fiber aspect ratio, large specific surface area and high porosity, and the fiber membrane has good air permeability; the blending with the eggshell membrane rich in hydrophilic groups enhances the hydrophilicity of the fiber membrane and improves the mechanical properties; and the modified cellulose acetate electrospun membrane has enhanced piezoelectric response and can be used as a potential green energy source for energy supply.

The invention relates to the technical field of functional nano materials, in particular to a ferroelectric polymer nanofiber membrane and a preparation method and application thereof.The preparation method comprises the steps that hexamethylene adipamide and formic acid are mixed to obtain a PA solution, and a polyamide electrospun membrane substrate is obtained through electrostatic spinning; the preparation method comprises the following steps: dissolving a ferroelectric polymer in N, N-dimethylacetamide to obtain a ferroelectric polymer solution; dropwise adding the ferroelectric polymer solution to the surface of a polyamide electrospinning membrane substrate, standing, forming a liquid membrane on the surface, adding water, immersing the polyamide electrospinning membrane substrate, carrying out vacuum filtration, and drying to obtain a ferroelectric polymer nanofiber membrane; the ferroelectric polymer comprises polyvinylidene fluoride or a polyvinylidene fluoride derivative. According to the prepared ferroelectric polymer nanofiber membrane, under the condition that the airflow speed is 0.45 m / s, the PM0.3 filtering efficiency is larger than or equal to 99.999%, the resistance is smaller than or equal to 250 Pa, and low air resistance and long-term stability are kept while efficient filtering is achieved.

The present application relates to the field of tissue engineering and biomedical materials, in particular to a macroporous multi-scale tissue engineering scaffold based on electrospinning and a preparation method and application thereof; first, a PU / PLCL blended electrospinning film is prepared, the electrospinning film is broken into a dispersion liquid and a gelatin solution, and the dispersion liquid and the gelatin solution are mixed at a certain ratio, and a three-dimensional tissue engineering scaffold is prepared by cross-linking the gelatin; the vascular tissue engineering scaffold has a macropore, good mechanical properties, a suitable swelling rate and a water contact angle, good biocompatibility, and to some extent, the structure of nanofibers is retained; and the present application can be applied to the field of artificial blood vessel materials and vascular transplantation biomedical materials.

The application discloses a method for modifying the hydrophilicity of an electrospun membrane based on seed coating-in-situ growth, and specifically, 2-acrylamido-2-methylpropanesulfonic acid (AMPs) is dissolved in a cellulose acetate spinning precursor solution, and after a fiber membrane is obtained through electrospinning, the membrane is subjected to secondary polymerization in an AMPs solution, so that a high-hydrophilic spinning membrane is obtained. The membrane shows good stability and uniformity. The contact angle of the modified membrane is tested, and the contact angle is far less than 90°, and slowly decreases with time, which indicates that the modified fiber membrane has strong hydrophilicity. The method is simple in process, easy to operate and suitable for large-scale production.