134results about How to "Promote regeneration" patented technology

The utility model relates to the technical field of liquid storage tanks, in particular to an integrated high-density polyethylene container for containing pressure-resistant cold and hot water, which comprises a tank body. A plurality of pipe orifices are formed in the side surface of the tank body; a boss is arranged at one end of the tank body; the boss is provided with an opening; a nut is embedded in the boss; the tank body, the pipe opening and the nut are integrally formed through extrusion blow molding. The tank body, the nut and the pipe orifice are integrally formed, so that an electric heating rod can be conveniently mounted subsequently; during use, a metal water pipe insert does not need to be additionally arranged, so that the whole sealing is safe and reliable; by arranging the annular clamping ring, the strength of the tank body is enhanced, and a mounting structure is provided; the tank body, the pipe orifice and the nut are integrally formed through extrusion blow molding, so that the whole body has the characteristics of high efficiency, simple process, low cost, easiness in recovery and easiness in regeneration; in the aspects of inlet and outlet pipelines, mounting positions and size series, the currently used metal liner can be directly replaced without any process change or accessory increase and decrease according to the specification of the current metal liner.

The invention provides a mesenchymal stem cell composition as well as a preparation method and application thereof in knee joint products, and belongs to the technical field of medicines. The invention relates to application of a mesenchymal stem cell combined naringin derivative in preparation of medicines for treating osteoporosis and repairing knee joint injury and arthritis. The naringin derivative is prepared from naringin through an ether esterification reaction, the metabolic cycle of the naringin derivative is prolonged and the water solubility is improved while the original activity is maintained, so that the free drug concentration and tissue infiltration capacity in bones are improved, the bioavailability of the naringin derivative is improved, and the bioavailability of the naringin derivative is improved. The prepared mesenchymal stem cell composition can induce mesenchymal stem cell osteogenic differentiation and improve bone repair capacity, has a good intervention effect on osteoporosis, has a sustained and controlled release effect and prolongs medicinal time.

This invention discloses a silk fibroin-based biomimetic artificial tympanic membrane with a gradient structure and its preparation method, comprising the following steps: encapsulating and dissolving an antibacterial drug in an organic solvent and then adding it dropwise to a silk fibroin solution; casting the film and inducing the formation of a β-sheet structure with methanol to obtain an outer dense layer; electrospinning the silk fibroin solution to obtain oriented silk fibroin fiber felt, and cross-linking it in an ethanol solution to obtain an intermediate fiber layer; mixing the silk fibroin solution with a pore-forming agent and casting it onto the intermediate fiber layer; covering the intermediate fiber layer with the outer dense layer; after pre-freezing and lyophilizing, immersing the membrane in deionized water to dissolve the pore-forming agent to form an inner porous layer; then placing it in a PBS buffer containing growth factors and shaking treatment; and finally drying to obtain the silk fibroin-based biomimetic artificial tympanic membrane with a gradient structure. This invention's three-layer biomimetic artificial tympanic membrane possesses antibacterial and regenerative functions, while also exhibiting excellent mechanical properties, meeting the requirements of a biomimetic tympanic membrane.

The invention provides a manufacturing method of fried chicken with buckwheat. The manufacturing method comprises the following steps: a first stage of burying chicken which is cut into a certain size and is processed in impurity-removed sauce to remove foreign flavor; a second stage of blanching the chicken from which the foreign flavor is removed in boiling water for 1-3 times; a third stage of removing moisture from the scalded chicken; a fourth stage of applying a fried coat to the chicken from which the moisture is removed; a fifth stage of frying the fried chicken with oil at a temperature of 170 DEG C for 7 minutes; in the sixth stage, the buckwheat mixed sauce is mixed on the fried chicken, the fried buckwheat is crushed by the buckwheat mixed sauce through a crushing machine, and 100 parts of the crushed buckwheat is added into the fried chicken; the sauce is prepared from the following raw materials in parts by weight: 100 parts of mixed water, 10-20 parts of syrup, 5-10 parts of tomato sauce, 10 parts of chili sauce, 10 parts of mixed seasoning, 3-5 parts of fragrant rice oil, 5 parts of jade-fold oil, 10 parts of tomato sauce, 2 parts of onions, 1 part of soy sauce, 2 parts of soy sauce, 1 part of curry, 0.5 part of L-sodium glutamate, 0.5 part of agricultural processed products, 0.5 part of fresh ginger and 0.3 part of red pepper extract pigment.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The present invention belongs to the fields of medicine, health care and food, and specifically relates to use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The technical problem to be resolved by the present invention is to provide the use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The composition of the present invention includes the alcohol and the cooling agent. Further, the composition includes an organic acid. The alcohol in the composition is 1%vol-99%vol, and the cooling agent therein is 0.05ppm-500ppm. The composition provided according to the present invention can play the role of regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality in a short period.

The invention relates to the technical field of biomedical materials and tissue engineering, and discloses sequential slow-release temperature-sensitive hydrogel and a preparation method and application thereof.The preparation method comprises the following steps that a blood sample is subjected to programmed centrifugation, and a gel layer of leukocyte-rich platelet-rich fibrin L-PRF and a gel layer of improved platelet-rich fibrin A-PRF are obtained respectively; and the gel layer is cut into pieces, pre-frozen, freeze-dried, ground and sieved, so that L-PRF freeze-dried powder and A-PRF freeze-dried powder are obtained respectively, and the methacrylic acid gelatin microspheres entrapped with the L-PRF freeze-dried powder are prepared. The microspheres and A-PRF freeze-dried powder are loaded into a temperature-sensitive hydrogel system composed of chitosan, polygalacturonic acid and sodium beta-glycerophosphate, so that the growth factors can be effectively entrapped in the hydrogel structure, and continuous release is realized; the system has good mechanical strength and structural stability, the retention time of the material in vivo is prolonged, and stable three-dimensional network support is provided.

The invention relates to preparation of graphene-loaded nano zero-valent iron and application of the graphene-loaded nano zero-valent iron in chromium-containing wastewater treatment. The preparation method comprises the following steps: preparing 60mL of a KBH4 solution with the concentration of 0.5 mol / L as a solution A and 60mL of a FeSO4. 7H2O solution with the concentration of 0.1 mol / L as a solution B, adding 0.25 g of a single-layer graphene oxide dispersion liquid into the solution B, stirring for 30 minutes, recording as a solution C, slowly dripping the solution A into the solution C, performing suction filtration separation on powder C, and drying to obtain nZVI-coated GO. The graphene is loaded with nZVI to adsorb chromium in chromium-containing wastewater, and nZVI-GO-Cr formed after wastewater treatment can be used as an auxiliary tanning agent for leather tanning or retanning sections and has good recyclability.

The present invention relates to the purification of immunoglobulins and the problem of providing a method for purifying an immunoglobulin in an efficient and cost-effective manner and with satisfactory purity and yield. In particular, the present invention addresses the aspect of the re-use of the rather cost-intensive chromatography materials, in particular the lifetime of the chromatography materials used in the capture step of the downstream process, and how this can be increased while reducing the technical complexity of the purification process.

This invention relates to the field of road engineering technology, and more particularly to a multi-objective performance coupling design method for warm-mix synchronously recycled SBS modified asphalt. The method determines the aging degree of aged SBS modified asphalt through testing, and accordingly determines the optimal dosage of the two-component synchronous recycling agent and the warm-mix agent. Subsequently, a diffusion model and a fusion degree calculation model for new and old SBS modified asphalt are established to quantitatively analyze the fusion degree of new and old asphalt under different temperatures and aged asphalt dosages. Based on this, a fusion degree spectrum is constructed, and by defining thresholds for each performance index, a feasible design scheme range for balanced performance is obtained, thereby determining the optimal mixing temperature and the maximum dosage of aged SBS modified asphalt. This invention can quickly determine the maximum allowable dosage of aged SBS modified asphalt and its corresponding optimal mixing temperature while considering multiple performance objectives, providing a reliable theoretical basis for the durability design of high-performance recycled SBS modified asphalt pavements.

The application provides a copper adsorption material and a preparation method and application thereof, and the copper adsorption material is prepared by using salicylic hydrazide monomers and methacrylic acid as raw materials through an emulsion polymerization method. The salicylic hydrazide monomers used in the application are salicylic hydrazide derivatives with introduced propylene bonds, and the multi-dentate coordination structure of the salicylic hydrazide derivatives can specifically chelate copper ions; the hydrophilic monomer used is methacrylic acid, and the carboxyl group of the methacrylic acid can bring good hydrophilic performance to the material and improve adsorption kinetics. The copper adsorption material of the application is applied to a mixed solution containing copper ions, nickel ions and cobalt ions to selectively separate copper ions.

The utility model discloses a solar full-spectrum-driven zero-carbon air conditioning system which comprises a solar photovoltaic system, a dehumidifier and a reverse-flow dew-point evaporative cooler. The solar photovoltaic system comprises a solar photovoltaic panel, a storage battery and a water tank, and a water cooling plate is arranged on the solar photovoltaic panel; the storage battery is used for storing electric energy generated by the solar photovoltaic panel and supplying power to the fan, and the water cooling plate is used for collecting heat generated by the solar photovoltaic panel and storing heated water in the water tank; the dehumidifier adopts an MOFs material as a desiccant and comprises two dehumidification modules, and the two dehumidification modules adopt a dehumidification-desorption alternate cycle working mode and alternately execute dehumidification operation and regeneration operation; the reverse-flow dew-point evaporative cooler comprises a dry channel and a wet channel, dry air dehumidified by the dehumidifier is divided into two parts at the tail end of the dry channel after passing through the dry channel, one part serves as working air to enter the wet channel to promote evaporation of a water film on the surface of the wet channel, and the other part serves as product air to be exhausted.

The invention discloses rhubarb polysaccharide as well as a preparation method and application thereof, the total sugar content of the rhubarb polysaccharide is 76.25%, the protein content is 3.4%, and the rhubarb polysaccharide contains active components (such as glucose, arabinose and galacturonic acid) in a specific proportion. The preparation method disclosed by the invention can be used for rapidly and efficiently extracting the rhubarb polysaccharide, and is low in energy consumption, simple and convenient to operate, low in process cost and suitable for large-scale industrial production. Meanwhile, the process ensures the stability and activity of the polysaccharide, and a wide prospect of providing drugs or food additives for preventing pancreatitis and regulating intestinal bacteria for the development and application of the rhubarb polysaccharide is provided. The rhubarb polysaccharide can obviously regulate intestinal flora disorder of mice with pancreatitis induced by arginine so as to up-regulate tight junction protein and promote tissue repair and regeneration, and has a great application prospect in the fields of regulating intestinal bacteria, preventing and treating hypertriglyceridemia type acute pancreatitis, metabolism-related new drugs and special medical food development and the like. Wide development and application prospects are realized.

This invention provides a mulberry leaf and wolfberry composition, comprising aqueous extracts of wolfberry, mulberry leaves, astragalus, yam, kudzu root, and green tea. This invention also provides oral preparations and food products containing this composition. Furthermore, this invention provides the application of the composition or oral preparation in the preparation of health foods that help maintain healthy blood sugar levels and hypoglycemic drugs. The composition provided by this invention has the effect of lowering blood sugar, and the selected raw materials are highly safe, have few toxic side effects, and are widely available, possessing significant market value and development prospects.

The application discloses a system and method for treating high-concentration cyclohexane oxidation tail gas. The system comprises an adsorption / desorption module and an absorption / desorption module, and can directly treat high-concentration cyclohexane oxidation tail gas while meeting the gas emission requirements. The system has the advantages of short overall process, high cyclohexane recovery rate, reasonable energy utilization, low energy consumption and the like.

The application provides a nano drug delivery system based on a Gap19 polypeptide. The system is prepared by mixing DSPE-PEG2k-Gap19 and ROS response material DSPE-TK-PEG5k-MPC to form nanoparticles, has a double-layer structure, and can enhance the stability and blood-spinal cord barrier penetration capacity of Gap19. The ROS response characteristics can realize damage microenvironment triggered drug release, simultaneously remove active oxygen and inhibit Cx43 hemichannel activity, and synergistically promote nerve repair. Experiments show that the system has good biocompatibility, targeted aggregation and functional recovery effect, and provides a new material and strategy for spinal cord injury treatment.

The invention discloses gallium ion imprinted amidoxime-based macroporous resin as well as a preparation method and application thereof, and belongs to the technical field of functional polymer materials and separation. The method comprises the following steps: pre-assembling a gallium trichloride template and monomers such as acrylonitrile, generating monodisperse liquid drops by utilizing a microfluidic technology, polymerizing by combining ultraviolet light, eluting the template by hydrochloric acid, and performing amidoximation modification by a hydroxylamine hydrochloride alkaline solution, thereby obtaining the resin. The resin is a monodisperse spherical microsphere, has a macroporous structure, has high selective recognition capability and high adsorption capacity on gallium ions, is fast in adsorption kinetics and good in regeneration performance, and is suitable for selectively separating or enriching gallium ions from a complex solution system.

The present invention relates to the purification of immunoglobulins and the problem of providing a method for purifying an immunoglobulin in an efficient and cost-effective manner and with satisfactory purity and yield. In particular, the present invention addresses the aspect of the re-use of the rather cost-intensive chromatography materials, in particular the lifetime of the chromatography materials used in the capture step of the downstream process, and how this can be increased while reducing the technical complexity of the purification process.

The invention provides a regenerated alkali metal poisoning NH3-SCR (selective catalytic reduction) catalyst as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing an alkali metal poisoned NH3-SCR catalyst with an ammonium salt solution, and carrying out post-treatment to obtain the regenerated NH3-SCR catalyst. The invention provides a preparation method of a regenerated alkali metal poisoning NH3-SCR catalyst, so that the NH3-SCR catalytic activity and hydrothermal stability of the regenerated alkali metal poisoning NH3-SCR catalyst at high temperature and low temperature are improved.

The invention discloses a method for transfecting a plant receptor by using a cell penetrating peptide. The method comprises the following steps: (1) constructing an expression vector of a cell penetrating peptide fusion protein CPPs-Cys-mCherry; (2) transforming an expression vector of the cell penetrating peptide fusion protein CPPs-Cys-mCherry into a protein expression system; (3) inducing expression of cell penetrating peptide fusion protein CPPs-Cys-mCherry by using IPTG (isopropyl-beta-d-thiogalactoside) to obtain a crude protein sample; (4) purifying the crude protein sample obtained in the step (3), and then adjusting the concentration of the cell penetrating peptide fusion protein CPPs-Cys-mCherry to 1-200 [mu] g / ml; and (5) transfecting different types of plant receptors by using a solution containing the cell penetrating peptide fusion protein CPPs-Cys-mCherry obtained in the step (4), and completing the transfection.

The application provides application of nervonic acid in preparation of a product for promoting hair regeneration, and relates to the biological field. The application of nervonic acid in preparation of the product for promoting hair regeneration includes that the concentration of the nervonic acid in the product is 3%-10%, at least one of the following is included in promoting hair regeneration: activating Wnt signal pathway in hair follicle stem cells, promoting expression of beta-catenin, LEF1 and PCNA, and further including promoting hair follicle organoid development in vitro and improving hair follicle regeneration capacity. It is found that the nervonic acid can act on the hair follicle stem cells, effectively promotes the hair follicle from the resting phase to the growth phase by activating the Wnt / beta-catenin and other regeneration pathways, and up-regulating the expression of PCNA, LEF1 and other proliferation-related factors, and promotes hair regeneration. The technology retains the high efficiency and safety of the nervonic acid regulation, further expands the new application scene of the nervonic acid in the field of hair regeneration, and has significant conversion value and broad market prospect in the field of clinical treatment of alopecia.

The present application relates to the technical field of road engineering pavement materials, in particular to a composite asphalt regenerant, a preparation method, a use method and an application thereof.The regenerant comprises, by mass percentage, 30-70% of aromatic component oil, 15-50% of hydrogenated base oil, 5-10% of a curing accelerator, 3-10% of a low-temperature stabilizer, 0.5-3.0% of an antioxidant, 0.5-5.0% of a diluent and 1-5% of an ammonium ion stabilizer.The present application significantly reduces the viscosity of the regenerant through multi-component synergy, realizes normal-temperature construction in all seasons, effectively restores the penetration and softening point of aged asphalt, delays secondary aging through the synergy of the antioxidant and the ammonium ion stabilizer, and simultaneously enhances the low-temperature crack resistance and initial strength of the recycled mixture, and is suitable for plant-mixed hot recycling, in-place hot recycling and cold recycling processes.

The invention relates to the technical field of daily chemical products and cosmetics, in particular to a scalp repair composition containing epidermis repair polysaccharide and saccharomycetes lysate. The skin repairing composition is prepared from the following raw materials in percentage by mass: 1 to 5 percent of skin repairing polysaccharide; 1%-5% of a yeast lysate; 1%-10% of PEG-5 (Polyethylene Glycol) glycerate triisostearate; and the balance of cosmetically acceptable matrix. The polysaccharide is mannan which is obtained by fermenting Paenibacillus sp.1538, and the weight-average molecular weight of the mannan is 6.15 * 10 < 6 > Da. The specific ultra-high molecular weight polysaccharide is compounded with the saccharomyces cerevisiae extract, and the low-irritation PEG-5 glycerate triisostearate is introduced, so that the compatibility problem that the high molecular weight polysaccharide is easy to flocculate is effectively solved. The composition can form a film immediately, deeply resist inflammation, relieve and repair a physical barrier of scalp, has an excellent synergistic effect, and solves the problem of scalp chemical stimulation injury caused by a traditional surfactant from the source.

The utility model belongs to the field of medical instruments suitable for orthopedic surgery, and particularly relates to a periosteum distraction device for a skull, which comprises a strip-shaped distraction plate bent in an arc shape, a sleeve and a distraction nail provided with external threads, one end of the distraction plate is provided with a combination hole penetrating through the upper surface and the lower surface, and the combination hole is composed of a groove and a threaded hole; a boss matched with the groove in an inserted mode is arranged on the end face of one end of the sleeve, and the sleeve is inserted into the groove in the convex face direction of the stretching plate. The distraction nail penetrates through the sleeve and then is in threaded connection with the distraction plate, the nail tail of the distraction nail extends to the outside of the sleeve, and the nail head of the distraction nail extends to the concave face side of the distraction plate and is configured to make contact with the bone surface. According to the distraction device, the distraction plate can be driven to rotate integrally by rotating the sleeve through the inserting and matching structure of the groove and the sleeve, flexible adjustment of the position of the distraction plate is achieved, periosteum can be stimulated in a targeted mode, and therefore regeneration of subperiosteal blood vessels can be promoted.

This application belongs to the field of traditional Chinese medicine, specifically relating to a spleen-strengthening and blood-activating traditional Chinese medicine preparation that enhances the expression of metallothionein and its uses. This application provides a traditional Chinese medicine composition comprising, by weight, the following raw materials: 1-20 parts jujube, 1-20 parts yam, 1-10 parts Buddha's hand, 1-9 parts Lithospermum erythrorhizon, 1-9 parts corn silk, 1-9 parts lotus leaf, 1-15 parts ginseng leaf, and 1-20 parts hawthorn. This application also provides a traditional Chinese medicine preparation, as well as the uses of the above-mentioned traditional Chinese medicine composition and preparation. The traditional Chinese medicine preparation provided in this application effectively enhances the liver's detoxification, antioxidant, and anti-inflammatory capabilities by increasing the expression of hepatic metallothionein, thereby reducing the probability of liver damage and preventing and delaying the further development of liver diseases.

The invention relates to the field of biological medicines, in particular to application of a hepatocyte nuclear factor 1 alpha (HNF1 alpha) in promoting beta cell regeneration and preventing and treating diabetes. Specifically, by regulating and controlling the expression of an HNF1alpha coding gene and the activity of HNF1alpha, pancreas islet alpha cells can be promoted to be transdifferentiated into beta cells to achieve beta cell regeneration, the functions of pancreas islet beta cells are reserved, the occurrence of diabetes mellitus is delayed, and a new medical approach is provided for prevention and treatment of diabetes mellitus.

The invention discloses an iron ion modified carbon nanotube as well as a preparation method and application thereof. The method comprises the following steps: pre-treating a multi-wall carbon nanotube, and introducing an active group on the surface of the multi-wall carbon nanotube to obtain a pre-treated carbon nanotube; dissolving an iron source in deionized water, adding a modifier, stirring and dissolving to obtain a modified solution; adding the pretreated carbon nanotubes into the modified solution, and stirring at a constant temperature to obtain a suspension; and drying the suspension, and calcining to obtain the iron ion modified carbon nanotube. According to the iron ion modified carbon nanotube material, efficient synergistic adsorption of dioxin and mercury is achieved by regulating and controlling the iron ion loading capacity and modification process parameters, meanwhile, the iron ion modified carbon nanotube material has excellent regeneration performance, and the blank that dioxin and mercury cannot be synchronously and efficiently treated through a single material in the prior art is filled up.

The invention discloses a novel oligopeptide PSP for angiogenesis and vascularized bone regeneration. The tripeptide innovatively screened by the invention is short in amino acid sequence, small in molecular weight, high in bioavailability, low in synthesis cost and easy to transport, modify and recombine. The tripeptide provided by the invention can significantly promote vascularized bone regeneration and improve skull defect repair. Good application prospects are realized.

The application provides a kind of propylene propane mixed gas separation trapping agent and its preparation method and propylene propane mixed gas separation method.The trapping agent includes solid adsorbent and organic solvent;The solid adsorbent is CALF-20;With the total mass of the trapping agent as 100%, the content of the solid adsorbent is 5wt%-45wt%, and the content of the organic solvent is 55wt%-95wt%.The MOF slurry trapping agent provided by the application has excellent effect on gas separation, with high propylene adsorption capacity, high propylene / propane selectivity, short equilibrium time, fast desorption speed, high regeneration performance and other advantages.