The invention, which relates to the technical field of biomedicine, provides a piezoelectric stent composition capable of realizing self-generating electricity stimulation as well as a preparation method and application thereof. The composition is composed of a biodegradable metabolic material and a piezoelectric material. With a 3D printing, jetting, pouring, extruding, die forming or electrostatic spinning method, the co-melt of the biodegradable material and the piezoelectric material or an organic solvent is formed into various biomedical application stents, especially nerve conduit stents. According to the invention, the mechanical energy in an in-vivo environment can be into electrical stimulation to promote regeneration, proliferation and differentiation of nerves, muscles, bones, blood vessels and the like without implantation of an external power supply or an electrode. The piezoelectric stent composition has advantages of being simple to prepare, low in cost, easy to controlin quality, wide in application range and the like. Rat in-vivo experiments show that the piezoelectric catheter stent has functions of promoting nerve regeneration and angiogenesis, relieving muscleatrophy and the like and has the broad clinical application prospects.