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A pharmaceutical composition for promoting nerve regeneration in stroke patients and its application

A nerve regeneration and stroke technology, applied in the field of medicine, can solve the problems of non-disclosure and achieve the effect of promoting the process of nerve regeneration and the recovery of motor function

Active Publication Date: 2018-09-28
吉林显锋科技制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art does not disclose that such compounds can be used for the treatment of cerebral nerve injury diseases such as stroke

Method used

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  • A pharmaceutical composition for promoting nerve regeneration in stroke patients and its application
  • A pharmaceutical composition for promoting nerve regeneration in stroke patients and its application
  • A pharmaceutical composition for promoting nerve regeneration in stroke patients and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Preparation of N'-(2-(1H-indol-3-yl)acetyl)-2-hydroxybenzohydrazide

[0013] (1) Add 8.8g (50mmol) of indole acetic acid (50mmol), methanol (60mL), and concentrated sulfuric acid (3mL) to a 500ml round bottom flask, and react at 70°C for 1-3 hours. water (50mL), separate the organic phase, extract the aqueous phase with ethyl acetate (3×20mL), combine the organic phases, wash with saturated sodium bicarbonate solution and water successively, dry over anhydrous sodium sulfate, and concentrate under reduced pressure to obtain indole The crude product of methyl acetate was directly used in the next reaction without further purification.

[0014] (2) Add 946g (48mmol) of methyl indole acetate, ethylene glycol methyl ether (40mL), and 5mL of hydrazine hydrate into a 500ml round-bottomed flask, heat and reflux at 115°C for about 20 hours, and detect by thin layer chromatography (TLC) The raw material was ignited, the reaction was stopped, cooled to room temperatur...

Embodiment 2

[0017] Example 2: Effect test of compounds on middle cerebral artery occlusion model

[0018] 55 adult SD rats, male, healthy and clean, with a body weight of 280-320 g, 15 rats were randomly selected as the sham operation group, and the rest of the rats were used to make the middle cerebral artery occlusion model as follows: use 0.4% pentobarbital Rats were anesthetized by intraperitoneal injection of sodium 10mL / kg, fixed on the operating table in the lateral position, along the midpoint of the line connecting the right external auditory canal and the outer canthus of the right eye, incised the skin about 2 cm perpendicular to the line, and then under the operating microscope along the temporal Cut the temporal muscle and masseter muscle in sequence, and separate them to the sides to expose the zygomatic arch. Use a rongeur to remove the zygomatic arch and cut the fascia along the skull to expose the anterior temporal fossa. Use a small distractor to widen the distance betwe...

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Abstract

The invention discloses a pharmaceutical composition for promoting stroke patient nerve regeneration and a use thereof. The pharmaceutical composition is an oral preparation and is prepared from an active component and pharmaceutic adjuvants. The active component is a N'-(2-(1H-indolyl-3-yl)acetyl)arylhydrazide compound shown in the formula. The pharmaceutical composition can inhibit nerve growth negative regulation and control factor expression through improving nerve growth positive regulation and control factor expression, promote nerve regeneration after stroke and promotes motion function recovery.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for promoting nerve regeneration in stroke patients and its application. Background technique [0002] Stroke is an acute brain injury caused by blockage or rupture of intracranial and extracranial blood vessels, which seriously endangers the life and health of middle-aged and elderly people, and is also one of the main causes of death and disability in middle-aged and elderly people. About one-third of stroke patients die shortly after onset, and survivors lose their jobs and even self-care ability due to sequelae such as hemiplegia and aphasia. At present, there are usually two methods for the treatment of stroke: one is to improve the oxygen and glucose insufficiency in the arteries by increasing blood flow; the other is to protect neurons, reduce the possibility of brain tissue ischemia, and reduce the excitotoxic death of neurons. N...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/405A61P9/10A61P25/28
CPCA61K31/405
Inventor 白强张毅
Owner 吉林显锋科技制药有限公司
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