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A pharmaceutical composition for nerve regeneration after ischemic stroke and its application

A technology for ischemic stroke and nerve regeneration, applied in the field of medicine, can solve problems such as non-disclosure, and achieve the effect of promoting the process of nerve regeneration and promoting the recovery of motor function.

Inactive Publication Date: 2019-02-26
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prior art does not disclose that such compounds can be used for the treatment of cerebral nerve injury diseases such as ischemic stroke

Method used

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  • A pharmaceutical composition for nerve regeneration after ischemic stroke and its application
  • A pharmaceutical composition for nerve regeneration after ischemic stroke and its application
  • A pharmaceutical composition for nerve regeneration after ischemic stroke and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Preparation of N'-(2-(1H-indol-3-yl)acetyl)-2-iodobenzohydrazide

[0013] (1) Add 8.8g (50mmol) of indole acetic acid (50mmol), methanol (60mL), and concentrated sulfuric acid (3mL) to a 500ml round bottom flask, and react at 70°C for 1-3 hours. water (50mL), separate the organic phase, extract the aqueous phase with ethyl acetate (3×20mL), combine the organic phases, wash with saturated sodium bicarbonate solution and water successively, dry over anhydrous sodium sulfate, and concentrate under reduced pressure to obtain indole Crude methyl acetate.

[0014] (2) Add 9.46g (48mmol) of methyl indole acetate, ethylene glycol methyl ether (40mL), and 5mL of hydrazine hydrate into a 500ml round-bottomed flask, heat and reflux at 115°C for about 20 hours, thin-layer chromatography (TLC) After detecting the disappearance of the raw material point, stop the reaction, cool to room temperature, add water (50 mL), stand still to precipitate a white solid, obtain the cr...

Embodiment 2

[0017] Example 2: Effect test of compounds on middle cerebral artery occlusion model

[0018] 55 adult SD rats, male, healthy and clean, with a body weight of 280-320 g, 15 rats were randomly selected as the sham operation group, and the rest of the rats were used to make the middle cerebral artery occlusion model as follows: use 0.4% pentobarbital Rats were anesthetized by intraperitoneal injection of sodium 10mL / kg, fixed on the operating table in the lateral position, along the midpoint of the line connecting the right external auditory canal and the outer canthus of the right eye, incised the skin about 2 cm perpendicular to the line, and then under the operating microscope along the temporal Cut the temporal muscle and masseter muscle in sequence, and separate them to the sides to expose the zygomatic arch. Use a rongeur to remove the zygomatic arch and cut the fascia along the skull to expose the anterior temporal fossa. Use a small distractor to widen the distance betwe...

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Abstract

The invention discloses a medicinal composition for nerve regeneration after ischemic cerebral stroke and application thereof, the medicinal composition is an oral preparation comprising an active ingredient and a medicinal supplementary material, wherein the active ingredient is N'-(2-(1H-indole-3-yl) acetyl)-2-iodobenzoyl hydrazine. The medicinal composition can increase the expression of a nerve growth positive regulation factor to inhibit the expression of a nerve growth negative regulation factor to promote the nerve regeneration process after the ischemic cerebral stroke so as to promote the rehabilitation of motor functions.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition for nerve regeneration after ischemic stroke and its application. Background technique [0002] Ischemic stroke is an acute brain injury caused by blockage or rupture of intracranial and extracranial blood vessels, which seriously endangers the life and health of middle-aged and elderly people, and is also one of the main causes of death and disability in middle-aged and elderly people. About 1 / 3 of the patients with ischemic stroke died shortly after the onset, and the survivors were disabled due to sequelae such as hemiplegia and aphasia and lost their ability to work or even take care of themselves. At present, there are usually two methods for the treatment of ischemic stroke: one is to improve oxygen and glucose insufficiency in arteries by increasing blood flow; the other is to protect neurons, reduce the possibility of brain tissue ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/405A61P25/00
CPCA61K31/405
Inventor 张洋白强张毅
Owner XUZHOU MEDICAL UNIV
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