46 results about "Nerves regeneration" patented technology

The invention discloses a structural bionic space-time coupled axon guidance-synchronous degradation type nerve implant as well as a preparation method and application thereof. According to the preparation method, after collagen and polyvinyl alcohol are compounded, freeze-drying is performed through a specific freeze-drying process to obtain the composite nerve implant with a bunchy multi-channel and porous structure, so that the defect that the degradation rate of a current application product is too high is overcome. The degradation rate required by the composite nerve implant is regulated and controlled according to the proportion of the composite materials, the composite materials which are rapidly degraded can be designed at the two ends of the composite nerve implant with the long length, and the composite materials which are slowly degraded can be designed at the middle part of the composite nerve implant with the long length, so that the mechanical performance required by nerve regeneration is supported. The obtained nerve implant not only is beneficial to preventing cicatrix tissues from entering, but also can be used as a topographic clue of nerve regeneration related cells to guide nerve regeneration, in addition, the degradation rate of the material is synchronous with the nerve regeneration process, and finally, the material is continuously degraded along with nerve regeneration and is replaced by new tissues.

According to the injectable double-layer drug sustained-release hydrogel and the preparation method and application thereof, hydrogel swelling and degradation curve and mechanical property detection shows that extrusion secondary injury to optic nerves can be avoided due to the swelling ratio ratio of 14% of inner-layer hydrogel to 10% of outer-layer hydrogel; the hydrogel precursor solution prepared by the preparation method disclosed by the invention has proper mechanical strength and adhesive force so as to cope with an in-vivo environment, has good injectability, can control the gelling time within 2 minutes, perfectly conforms to a short time window of optic nerve decompression surgery, and has extremely high clinical practical value. The problems that the serious operation risk of cerebrospinal fluid leakage during optic nerve local administration and a traditional local administration carrier lacks in-situ stability and is prone to displacement are solved, the damaged microenvironment can be cooperatively regulated and controlled, and long-acting slow release of nerve regeneration is promoted; multiple functions such as operation safety, medicine long-acting slow release, biocompatibility and operation convenience are successfully integrated, and an unprecedented effective strategy is provided for solving the clinical problem of optic nerve injury.

The application belongs to the field of medical biological materials, and relates to a preparation method of a hierarchical nanofiber composite film for nerve repair and application thereof. The method comprises the following steps: preparing multilayer nanofibers with different internal stresses through continuous multiple electrostatic spinning units, stacking the multilayer nanofibers with different internal stresses to form a composite nanofiber film with an internal stress gradient; chemically crosslinking the composite nanofiber film; performing adhesion molecule adhesion treatment on the upper surface of the composite nanofiber film; and preparing the hierarchical nanofiber composite film with an internal stress gradient and capable of self-deforming under the action of liquid to wrap nerves. The film provided by the application has excellent flexibility, biocompatibility and degradation performance, can efficiently and quickly adhere to the surface of damaged nerves, provides a good support microenvironment for nerve cell growth, promotes nerve regeneration and repair, and has a wide application prospect in the field of peripheral nerve injury repair.

The present application relates to the technical field of medical image processing, in particular to an image intelligent analysis system for corneal nerve fibers of dry eye patients, which comprises an image acquisition module, an image preprocessing module, a nerve fiber segmentation module, a nerve morphological analysis module based on differential geometry, a nerve regeneration monitoring module, a data management module and a clinical auxiliary decision module. The nerve morphological analysis module based on differential geometry is the core innovation, which contains a nerve fiber curvature analysis unit, a multi-scale differential invariant extraction unit and a nerve network topology structure quantification unit. The system introduces the theory of differential geometry, represents the nerve fiber through a parameterized curve and calculates the local curvature characteristics. A Gaussian scale space is constructed to extract multi-scale differential invariants. The graph structure representation of the nerve network is established to analyze the topological characteristics. The morphological characteristics of the corneal nerve fibers can be quantified comprehensively from the local curvature to the global topological structure, and the accurate detection of the slight changes of the nerve fibers is realized.

The invention relates to a degradable nerve repair membrane and a preparation method thereof, and belongs to the technical field of nerve repair membranes, the degradable nerve repair membrane comprises a biological composite structure inner layer, a support outer layer and a bonding layer, and the biological composite structure inner layer and the support outer layer are bonded through the bonding layer. According to the invention, polypyrrole with excellent electrochemical activity, environmental stability, controllable conductivity and poor mechanical properties and collagen nanofibers with high biocompatibility and capable of forming a nano-scale fiber network are adopted to form a conductive-biological composite structure as an inner layer through electrostatic spinning, and the PLGA porous membrane is prepared through 3D printing. A PLGA porous membrane with parallel axial microchannels on the surface is used as an outer layer, so that the membrane body structure can effectively guide directional growth of axons while ensuring conductivity, accurate preparation can be realized according to needs, the degradation period is matched with the nerve regeneration rate, and the degradation time can be regulated and controlled through the proportion of a copolymer; the repairing effect is prevented from being influenced by too fast or too slow degradation.

The present application relates to a kind of water gel support prepared by self-assembled polypeptide and the use of support obtained therefrom, the preparation method includes: 1) self-assembled peptide sequence is linked nerve growth factor analog peptide by covalent bond to obtain bonded functional polypeptide;2) macrophage is separated and cultured, and is induced to be " alternative activation " anti-inflammatory M2 macrophage, obtain culture supernatant and carry out filtration, obtain filtered cell culture supernatant;3) filtered cell culture supernatant is mixed with bonded functional polypeptide, obtain mixed solution and adjust the concentration of the mixed solution, the bonded functional polypeptide self-assembles and forms water gel support.The present application uses M2 macrophage condition culture supernatant to construct regenerative microenvironment, combines polypeptide functional water gel support, realizes better overall interaction, and prepares the water gel support that can supplement and regulate nerve regeneration, the support can promote nerve cell regeneration behavior, provides new selection for tissue engineering biomaterials.

The invention provides a sequential slow-release hydrogen sulfide nerve repair conduit and a preparation method thereof, and belongs to the technical field of biological materials. The sequential slow-release hydrogen sulfide nerve repair conduit comprises degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel and a pH response hydrogen sulfide donor, wherein the degradable polymer conduit is filled with the degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, and the pH response hydrogen sulfide donor is loaded on the hydrogel. In the application, the pH response donor can respond to an acidic microenvironment of degradation of polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, release hydrogen sulfide and relieve the acidic environment generated by degradation of the hydrogel at the same time, and form a dual supply mechanism with cysteine (endogenous hydrogen sulfide precursor) obtained by degradation of the hydrogel; nerve regeneration and angiogenesis are synergistically promoted, and oxidative stress is regulated; and the hydrogel is accelerated to degrade during excessive oxidative stress, so that hydrogen sulfide is released as required, and the core problems of insufficient blood supply, unbalanced acidic microenvironment and slow nerve regeneration are synchronously solved.

An aligned nanofiber-based nerve-guidance conduit is provided which acts as a structural guide for assisting regeneration of a damaged nerve, and which provides an environment suitable for nerve regeneration through a porous channel. The nerve-guidance conduit is made of a material having biodegradability so that no additional removal surgery is required even after nerve regeneration is completed. In addition, the nerve-guidance conduit is composed of a piezoelectric material that generates electricity during deformation. Thus, a scheme for promoting the regenerative ability of nerve cells through electrical stimulation generated when the guidance conduit is deformed is proposed.

The application discloses an injectable double-layer drug sustained-release hydrogel and a preparation method and application thereof, and relates to the field of drug sustained-release hydrogels. The swelling and degradation curve and mechanical property detection of the hydrogel show that, when the swelling rate ratio of the inner layer hydrogel to the outer layer hydrogel is 14% to 10%, the secondary damage of the optic nerve caused by extrusion can be avoided; meanwhile, the hydrogel has suitable mechanical strength and adhesion to cope with the in-vivo environment. The hydrogel precursor solution has good injectability, and the gelation time can be controlled within 2 minutes, which perfectly matches the short time window of the optic nerve decompression surgery, and has high clinical practical value. The application solves the major surgical risk of cerebrospinal fluid leakage when the optic nerve is locally administered, and solves the problems of the traditional local drug carrier, such as lack of in-situ stability and easy displacement. The application can synergistically regulate the injury microenvironment and promote the long-acting sustained-release of nerve regeneration, successfully integrates multiple functions such as surgical safety, drug long-acting sustained-release, biocompatibility and operation convenience, and provides an unprecedented effective strategy for solving the clinical problem of the optic nerve injury.

The invention discloses an application of an MMP7 inhibitor MMP-7-IN-1 in preparation of a medicine for inhibiting formation of fiber scars and promoting tissue regeneration. Research results show that MMP-7-IN-1 can effectively inhibit fibroblast excessive proliferation and collagen deposition, improve local extracellular matrix microenvironment and provide favorable conditions for tissue repair, so that fiber scar formation is inhibited, and tissue repair and nerve regeneration are promoted; secondly, the inhibitor MMP-7-IN-1 has good structural stability, can be directly administered or be matched with other carriers for administration, is simple and convenient to operate and low in cost, and avoids the problem of toxic residues possibly generated in traditional chemical modification. Therefore, the invention provides clinical application of MMP-7-IN-1 in prevention and treatment of fiber scar related diseases and repair of various tissue damages, and the MMP-7-IN-1 shows remarkable practical value and popularization potential.

The application provides a ROS-regulated hydrogel loaded with acid koumiss-derived exosomes and a preparation method and application in preparation of burn drugs, and belongs to the technical field of burn drugs. The acid koumiss-derived exosomes (K-Exo) are wrapped by using silk fibroin peptides, and the obtained nano drug-loaded fibrous microcrystals can be used as a ROS-responsive nano drug-loaded sustained-release system of K-Exo. When the microenvironment of a burn site highly expresses ROS, the silk fibroin nano fiber microcrystals are dissolved, K-Exo is released, the ROS content and inflammatory cell infiltration at the damage site are effectively reduced, and the skin at the burn site is rapidly healed. The K-Exo is loaded into the GelMa hydrogel, and the obtained hydrogel shows broad-spectrum antioxidant and anti-inflammatory biological effects, as well as active regulation of the immune system, ROS-responsive controlled release, promotion of cell migration ability, nerve regeneration and blood vessel regeneration, so that the repair of large-area burn non-healing wounds can be improved.

The invention discloses a resveratrol and nerve growth factor loaded chitosan-polydopamine modified 3D printing biological material as well as a preparation method and application thereof in spinal cord injury repair, the structure and function of the biological material simulate a natural extracellular matrix (ECM) tissue structure to fill cavities in a spinal cord injury area, and tissue regeneration can be guided; meanwhile, the compound can be used as a carrier of medicines, cells or bioactive factors. According to the material, a three-dimensional porous PLA support with an accurate structure is printed through a fused deposition modeling (FDM) technology to serve as a carrier for cell compatibility and physical supporting, CS is loaded in the three-dimensional porous PLA support through a freeze drying technology, PDA carrying NGF is loaded on the surface of the three-dimensional porous PLA support, Res is loaded through the physical adsorption effect, and the multifunctional 3D biological composite material for spinal cord injury repair is prepared. Through the synergistic effect of anti-inflammatory, anti-oxidation, anti-apoptosis and other ways, a microenvironment beneficial to nerve regeneration is created together, and functional recovery after spinal cord injury is significantly promoted.

The application discloses a traditional Chinese medicine plaster for lumbar disc herniation and a preparation method thereof, and relates to the technical field of biological medicine. In the microneedle layer, macromolecular antler active components are loaded, and a liposome transition depot layer and an enzyme-responsive hydrogel controlled-release layer are constructed on the surface of the microneedle layer. Through the system integration of the three-layer structure, a complete treatment chain of puncture, transdermal penetration, transition depot, intelligent response and controlled release is constructed. The microneedle layer breaks through the physical barrier of the stratum corneum, directly delivers the antler active components and analgesic anti-inflammatory components to the dermis layer, and realizes rapid effect. The liposome transition depot layer provides secondary release and protection, maintains the drug concentration platform, and realizes continuous supply. The enzyme-responsive hydrogel controlled-release layer intelligently adjusts the drug release rate according to the pathological state of the lesion, and realizes on-demand drug release. The antler active components promote the repair of nucleus pulposus cells and nerve regeneration, and the CeO2@PDA nanoenzyme removes ROS to improve the microenvironment, realizing the treatment of both the symptoms and the root cause.

The invention provides a multifunctional drug delivery nerve conduit and a preparation method thereof, and belongs to the technical field of biological materials. Degradable microgel-based hydrogel filled in multifunctional drug delivery nerve conduit and multi-effect drug sustained-release nanoparticle methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly [methoxy polyethylene glycol-poly] loaded in degradable microgel-based hydrogel] The invention relates to a phenylboronic acid-diethylaminoethyl methacrylate-co-N-(2-nitroso mercaptan ethyl)-methacrylamide-co-methyl methacrylate) nano particle. The nano particle is prepared from phenylboronic acid and diethylaminoethyl methacrylate, according to the multifunctional drug delivery nerve conduit, multi-effect drug sustained-release nanoparticles and microgel-based hydrogel are combined, so that more cell adhesion sites are provided for nerve regeneration, and p-hydroxybenzyl alcohol is released through slow release of nitric oxide and active oxygen response; the problems that response release drugs cannot be treated in time and slow release drugs cannot be released as required are solved, dynamic adjustment of a nerve injury part regeneration microenvironment is achieved, and nerve regeneration and functional recovery are promoted.

The invention provides a dental pulp stem cell exosome-loaded acellular tissue engineering nerve conduit as well as a preparation method and application thereof, relates to the technical field of biomedical engineering and nerve regeneration medicine, and aims to solve the problems of poor mechanical property, low bionic degree, high degradation rate, insufficient biological activity and the like of an existing nerve conduit. The technical key point of the invention is as follows: the dental pulp stem cell exosome-loaded acellular tissue engineering nerve conduit is provided, and the nerve conduit is obtained by loading a nanofiber conduit with enhanced function of over-expressing let-7i-5p, the porous nanofiber catheter is a porous catheter which is obtained after a polyvinyl alcohol (PVA)-chitosan (CS)-graphene (G) electrostatic spinning membrane is subjected to pipe reeling and crosslinking, and the nucleotide sequence of let-7i-5p in DPSC-Exo is shown as SEQ NO.1. The invention further discloses a preparation method of the porous nanofiber catheter.

The present invention relates to an aqueous ophthalmic composition comprising spirolactone, cyclodextrin and tromethamine, preferably for topical application to the human eye. The present inventors advantageously dissolve spirolactone in the HP-gamma cyclodextrin excipient at a concentration of 0.1%, which dose has been demonstrated to be effective in the treatment of ocular surface defects. They also have successfully demonstrated that the spirolactone eye drops are stable for up to 9 months at 4 DEG C and achieve its efficacy within at least 6 months, and the formulation is well tolerant after multiple daily instillations within 7 days. In addition, the spirolactone eye drops provided by the invention accelerate healing of corneal wounds of rats, reduce corneal edema and inflammation, enhance epithelial integrity and improve nerve regeneration, and prompt recovery of corneal homeostasis. Thus, the invention also relates to the use of an aqueous ophthalmic composition for the treatment of ocular diseases and disorders.

The present application relates to the technical field of biological medicine, in particular to a functionalized targeted liposome and application thereof, comprising: lipids and a targeting ligand; wherein the targeting ligand can specifically bind to a TREM2 receptor. The liposome of the present application can specifically bind to the TREM2 receptor by means of the targeting ligand, realize precise targeting of cells containing the TREM2 receptor on the surface, ensure direct action on target cells, and further improve the precision of delivered substances. The liposome has targeting property, high stability, small side effects, and can be applied to the development of drug carriers, pharmaceutical compositions, etc., and has a wide application prospect. For example, the liposome of the present application is dynamically connected with a hydrogel molecule by a borate ester bond to prepare a hydrogel pharmaceutical composition containing the functionalized targeted liposome of the present application. The hydrogel pharmaceutical composition can release the liposome of the present application according to the change of pH and ROS in the surrounding environment in response to an inflammatory environment, and target cells containing the TREM2 receptor on the surface, i.e. microglial cells (having the TREM2 receptor on the surface), by virtue of the targeting ligand exposed on the surface, and regulate the polarization state of the cells, inhibit the polarization of the cells to the pro-inflammatory M1 type, and promote the polarization of the cells to the anti-inflammatory M2 type, thereby improving the local microenvironment of the spinal cord injury site and promoting nerve regeneration.

The present invention provides a pharmaceutical composition capable of accelerating the regeneration rate of damaged areas in nerves. [Solution] A pharmaceutical composition for promoting nerve regeneration, comprising (A) a hyaluronic acid derivative into which a cholesteryl group has been introduced, (B) one or more factors selected from the group consisting of secretory sialic acid-binding immunoglobulin-like lectin-9 and monocyte chemotactic factor-1, and (C) a cell adhesion material derived from collagen; the average molecular weight of the hyaluronic acid derivative into which the cholesteryl group has been introduced is 5,000 or more and 50,000 or less; and a method for promoting nerve regeneration, comprising contacting any of the pharmaceutical compositions with a damaged site in nerve tissue.

Disclosed herein are compositions comprising containers and silk elements. Disclosed herein are methods of regenerating an at least partially severed nerve cell. Disclosed herein are compositions for regenerating an at least partially severed nerve cell.

The invention relates to a nerve regeneration inducing material. The present invention provides a non-tubular nerve regeneration inducing material for regenerating a nerve injury part, the material comprising: (A) a crosslinked body obtained by covalently crosslinking a bioabsorbable polysaccharide having a carboxyl group in the molecule with a low endotoxin with at least one crosslinking agent selected from the group consisting of compounds represented by general formula (I) and salts thereof; and (B) a bioabsorbable polymer. R1 HN-(CH2) n-NHR2 (I) [In the formula, R1 and R2 each independently represent a hydrogen atom or a group represented by the formula-COCH (NH2)-(CH2) 4-NH2, and n represents an integer of 2-18]. As a result, a medical material capable of inducing regeneration of a nerve injury part is provided.

This invention provides a magnetically and thermally controlled dynamically powered nanomotor neural graft and its preparation method. The neural graft consists of a biodegradable polymer fiber conduit, an internally filled thermosensitive hydrogel, and a nanomotor loaded on the hydrogel. The surface of the nanomotor is loaded with energy molecules such as succinic acid. The nanomotor is prepared using a highly magnetically responsive material and achieves directional guidance under an applied magnetic field. Heat generated under an alternating magnetic field triggers a gel-sol transition in the thermosensitive hydrogel. Energy molecules are continuously released to increase local ATP levels, maintain cellular homeostasis, and support axonal regeneration and synaptic remodeling. This invention combines the advantages of magnetically driven directional navigation and thermosensitive controlled release, overcoming the shortcomings of traditional methods such as insufficient directionality and energy depletion. The graft exhibits good biocompatibility and is biodegradable, can regulate the immune microenvironment of damaged nerves, avoid oxidative stress, and efficiently promote the regeneration and functional recovery of long-segment damaged peripheral nerves.

The present invention relates to a cranial penetration-type nerve flexible electrode. The cranial penetration-type nerve flexible electrode may comprise: a front end portion having a needle hole; an electrode portion comprising a circuit and at least one of an electrode and a nerve regeneration-inducing electrode; and a terminal portion including a circuit connection pad. The nerve flexible electrode of the present invention enables stable stimulation / measurement at an accurate position for a long period of time, and enables nerve signal analysis and electrical stimulation in various areas.

The application discloses a traditional Chinese medicine small-molecule conductive hydrogel for repairing nerves and a preparation method and application thereof, and belongs to the technical field of biomedical materials.The preparation method is as follows: firstly, mix tannic acid and 5-formyl-2-furan boronic acid in a buffer solution and adjust the pH value to neutral or weak alkaline; then introduce carboxymethyl chitosan and poly(3,4-ethylenedioxythiophene) / polystyrene sulfonate solution; and construct a double dynamic crosslinking network by using borate ester bonds formed by the tannic acid and the 5-formyl-2-furan boronic acid and Schiff base bonds formed by the carboxymethyl chitosan and the 5-formyl-2-furan boronic acid.The hydrogel has excellent injectability and self-healing property, can realize antioxidation and anti-inflammation of a damaged microenvironment and reconstruction of a bioelectric pathway in cooperation, and thus promotes nerve regeneration and conduction recovery.

This application provides a multifunctional drug delivery nerve conduit and its preparation method, belonging to the field of biomaterials technology. The multifunctional drug delivery nerve conduit is internally filled with a biodegradable microgel-based hydrogel and multi-effect drug-releasing nanoparticles (methoxy polyethylene glycol-poly[phenylboronic acid-diethylaminoethyl methacrylate-co-N-(2-nitrosothiol ethyl)-methacrylamide-co-methyl methacrylate] nanoparticles loaded within the biodegradable microgel-based hydrogel. This multifunctional drug delivery nerve conduit combines multi-effect drug-releasing nanoparticles with a microgel-based hydrogel, not only providing more cell adhesion sites for nerve regeneration but also addressing the challenges of timely drug release and on-demand drug release through the sustained release of nitric oxide and reactive oxygen species in response to p-hydroxybenzyl alcohol. This achieves dynamic regulation of the regenerative microenvironment at the nerve injury site, promoting nerve regeneration and functional recovery.

The use of Gastrodia and Uncaria granules, which is used for preparing a medicine for treating peripheral nerve injury, such as sciatic nerve injury. The present application confirms that Gastrodia and Uncaria granules can accelerate the nerve regeneration and functional recovery after peripheral nerve injury, and the effective dose of the effect is 1.5 g / kg of Gastrodia and Uncaria granules. The present application expands the medication range of Gastrodia and Uncaria granules, and provides a theoretical basis for the clinical application of Gastrodia and Uncaria granules in treating peripheral nerve injury.

This invention discloses a magnetron piezoelectric composite hydrogel and a method for preparing the composite hydrogel, comprising: modifying barium titanate with tannic acid to prepare tannic acid-functionalized barium titanate nanoparticles; modifying superparamagnetic Fe3O4 nanoparticles with carboxyl-terminated polyethylene glycol to obtain carboxylated superparamagnetic nanoparticles; uniformly dispersing the tannic acid-functionalized barium titanate nanoparticles and carboxylated superparamagnetic nanoparticles in deionized water to form a suspension, and then adding polyvinyl alcohol and glycerol to react and obtain the magnetron piezoelectric composite hydrogel. This invention also discloses the application of the above hydrogel in promoting the repair of peripheral nerve injuries. The composite hydrogel of this invention can remotely, non-invasively, and precisely convert mechanical stress into electrical signals that promote nerve regeneration, and can also exert anti-inflammatory and antioxidant stress-regulating microenvironment functions, providing a powerful intelligent platform for the functional regeneration of peripheral nerves.

The invention relates to the technical field of microbial medicines, and particularly discloses application of intestinal golden thread bacteria in preparation of a medicine for preventing or treating peripheral nerve injury. A mouse model proves that the intestinal golden thread bacteria can regulate the injury microenvironment in the peripheral nerve injury repair process, guide nerve axons to extend in the expected direction and reduce uncontrolled axon growth and wrong dominance, so that the structural accuracy of nerve regeneration is improved.

The invention relates to a vector containing an Elac2 gene and application of the vector in nerve injury related diseases. Specifically, the invention provides an adeno-associated virus vector containing an Elac2 gene, and the adeno-associated virus vector can be constructed by a three-plasmid system: an AAV-CAG-ELAC2 vector plasmid, a pAAV2-RC packaging plasmid and a pAAV-Helper. According to the invention, the Elac2 and the encoding protein thereof are used for nerve protection and nerve regeneration, a gene therapy means is provided for nerve regeneration, and a new way is opened up for treatment of related diseases.

The invention provides a drug-loaded vesicle, application thereof and a drug for treating spinal cord injury, and relates to the technical field of biomedicine. The drug-loaded vesicle provided by the invention can improve a nerve regeneration microenvironment of an injured part, relieve inflammation and promote nerve regeneration of the injured part, has a positive promoting effect on structure and function recovery after spinal cord transection injury, provides a new treatment strategy for clinical treatment of spinal cord injury, and has remarkable clinical transformation potential.

The invention discloses a panoramic intelligent rehabilitation management system for burn patients, and relates to the technical field of medical health informatization. Comprising a multi-target coupling modeling module, a multi-source state sensing module, a conflict identification calculation module, an intervention priority regulation and control module, a feedback calibration analysis module and a dynamic closed-loop control module, a rehabilitation stage multi-target model containing a coupling relationship among a skin healing target, a joint flexibility recovery target and a nerve regeneration target is constructed, a sensitive intervention window is identified according to a physiological change rule of each target in a rehabilitation period, and a target conflict mapping matrix with a time sequence attribute is generated. Through multi-target coupling modeling and a dynamic conflict regulation and control mechanism, intelligent cooperative control over multi-target intervention in the whole burn rehabilitation process is achieved, intervention safety and individual adaptability are improved, closed-loop optimization capacity is achieved, rehabilitation efficiency is remarkably improved, medical risks are reduced, and wide clinical application prospects are achieved.