90 results about "Stimulus pulse" patented technology

The application discloses a cochlear implant multi-channel stimulation pulse half-wave detection system and method, and relates to the technical field of cochlear implants, in particular to a cochlear implant multi-channel stimulation pulse half-wave detection system and method. The system comprises a test board, a head piece and a speech processor, and further comprises a half-wave detection unit and a multi-channel collector. The test board comprises a receiving coil, a stimulator, a stimulation electrode and a test electrode terminal. The speech processor receives and processes sound signals and encodes the sound signals. The encoded signals are transmitted to the receiving coil through the head piece. After decoding processing by the stimulator, pulse signals with corresponding frequencies and current intensities are generated and transmitted to each stimulation electrode. The stimulation electrode is connected to the test electrode terminal. The test electrode terminal is connected to the multi-channel collector. The multi-channel collector is connected to the half-wave detection unit. The multi-channel collector combines n stimulation electrodes to transmit signals to the half-wave detection unit for half-wave detection. The application utilizes the multi-channel collector and the half-wave detection unit to realize automatic half-wave detection, reduce labor costs, and improve the efficiency and success rate of half-wave detection.

Systems and methods of wirelessly powered stimulators and implantable pulse generators that can generate stimulations with programmable amplitudes and RF spectrum control in the RF domain are described. An embodiment includes an implantable pulse generator that includes: an Rx antenna configured to receive a radio frequency (RF) signal: a demodulator coupled to the Rx antenna, the rectifier, and a source, and configured to control an output of a train of mini-pulses, based on the RF signal, each mini-pulse having a voltage amplitude and a pulse width (on-portion) smaller than a pulse width TO; and stimulation circuitry 250 coupled to receive the train of minipulses and deliver the train of mini-pulse to an electrode, where the train of mini-pulses to the electrode effectively corresponds to a stimulation pulse, having a pulse width TO and an amplitude that is a function of the pulse widths of the mini-pulses.

The invention discloses a rehabilitation system and method based on motor imagery electroencephalogram signals and eyeball tracking. The rehabilitation system comprises a signal acquisition module used for acquiring the motor imagery electroencephalogram signals and recording limb state information; the signal processing module is used for storing the collected motor imagery electroencephalogram signals, determining a motor intention through the motor imagery electroencephalogram signals and outputting a selection instruction; the eyeball tracking module is used for tracking an eyeball watching interface prompt instruction and cooperatively sending a treatment instruction with the selection instruction; and the electrical stimulator module is used for receiving the treatment instruction and outputting stimulation pulse current according to the treatment instruction. Through cooperation of real-time collection of non-invasive motor imagery signals and an eyeball tracking technology, the defects that a single motor imagery electroencephalogram signal is few in classification mode and low in real-time classification precision are overcome, rehabilitation training modes of different parts are autonomously selected according to the intention of a subject, the initiative and enthusiasm of a patient in the rehabilitation training process are improved, and the rehabilitation training efficiency is improved. The rehabilitation treatment effect of the patient is effectively improved.

A method of conducting operations for an IPG adapted to provide electrical pulses to tissue of a patient for medical therapy is provided. The IPG provides the medical therapy according to pulse parameter data executed according to an execution path. The method can include identifying a root node repeated within the execution path of a first set of the pulse parameter data, identifying a stimulation pulse pattern repeated in the first set between occurrences of the root node, replacing the repeated pattern with (a) a single instance and a recurrence count or (b) a pointer to a reference pattern to generate a second set of the pulse parameter data, and communicating the second set between the external controller and the IPG and / or storing the second set within a memory of the IPG.

A system (10) for neuromodulation and / or neurostimulation for treating a mammal, comprising at least:-at least one control unit (12) configured and arranged to provide stimulation data; -at least one stimulation unit (14) configured and arranged to provide stimulation pulses; -at least one real-time monitoring unit (18); -at least one signal processing unit (16); wherein the system (10) is configured and arranged for controlling blood pressure wherein the stimulation unit (14) is configured to comprise a lead (20), and wherein the lead (20) is capable and configured to provide stimulation to the spinal cord at a site T9-L1.

Methods, systems, and computer-implementable algorithms for determining time-varying pulses for a patient with an implantable stimulator device (ISD) are disclosed. At least one time-invariant tonic stimulation pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce a time-varying pulse (TVP), and one or more measurements are made to determine the effectiveness of the TVP. The measurements can be objective and taken from the patient, and / or subjective and determined based on feedback from the patient. In one example, the objective measurements can include one or more features determined from an epidural spinal cord electrogram (ESG) signal detected by the ISD, which can include an evoked compound action potential. The one or more measurements are used to determine a score for the TVP, which is useful in selecting the best TVP for use with the patient, or for adjusting the modulation function applied to the tonic stimulation parameters.

This application relates to the fields of biomedical engineering and rehabilitation engineering technology, and discloses a functional electrical stimulation method and system based on physiological simulation and adaptive closed-loop feedback. The method includes: calculating an ideal muscle activation curve based on a target trajectory; performing spatiotemporal asynchronous co-coding to generate a biomimetic stimulation pulse sequence by simulating temporal asynchrony, spatial and intensity modulation, and multi-muscle synergistic timing; simultaneously applying stimulation while monitoring the actual kinematic state and muscle physiological state in real time using sensors; and dynamically adjusting the internal parameters of the spatiotemporal asynchronous co-coding (T-S-C coding) based on the evaluation results of trajectory error and fatigue index to form an adaptive closed loop. This application, by combining biomimetic coding with an intelligent closed loop, fundamentally solves the problems of motion stiffness, muscle fatigue, and poor control precision caused by traditional FES, achieving smooth, sustained, and precise personalized motor function rehabilitation.

Embodiments of the invention provide a system and method for delivering a stimulating treatment or relief to a patient. The system includes a pair of stimulating electrodes coupled to an article that can be coupled to a patient to deliver stimulation controlled through a wired or wireless link. The system includes a controller that can generate and apply stimulating pulses to the pair of stimulating electrodes based on a stimulation program and signals or data. The system includes a sensor coupled to the controller and the article and a user interface that enables a user to remotely view or exchange information through the link and monitor and set or reconfigure the stimulating pulses. In some embodiments, the article includes a brace assembly that can be a brace, a strut, a sleeve, a sling, a garment, a wrap, or a band.

This invention describes techniques for a medical device that delivers electrical stimulation using a current or voltage regulator with an adjustable principal amplitude. An exemplary method includes: receiving user input indicating a desired current amplitude via a programmer for an electrical stimulator; and selecting a first fractional adjustment or a second fractional adjustment as a target adjustment for achieving the desired current amplitude. A neural modulation system includes: a first electrode; a second electrode; a stimulation generator configured to deliver a first stimulation pulse to the first electrode and a second stimulation pulse to the second electrode, wherein a first current amplitude of the first stimulation pulse is a first fraction of the principal amplitude and a second current amplitude of the second stimulation pulse is a second fraction of the principal amplitude; and a processor configured to: generate initial instructions for the stimulation generator to perform: (i) deliver the first analog pulse based on the first fraction of the principal amplitude, and (ii) deliver the second stimulation pulse based on the second fraction of the principal amplitude, receiving user input including the desired current amplitude. The processor determines, based on the desired current amplitude, the adjustment of the first current amplitude of the first stimulation pulse to be required, and determines a target adjustment based at least in part on a comparison of the desired current amplitude with the main amplitude, wherein the processor is further configured to: (A) determine an adjustment to at least the first fraction as the target adjustment, or (B) determine the following as the target adjustment: (i) an adjustment to the main amplitude, and (ii) an adjustment to at least the second fraction relative to the main amplitude adjustment, and, based at least in part on the target adjustment, generate adjustment instructions for the stimulation generator to deliver the first stimulation pulse with the desired current amplitude and the second stimulation pulse with approximately the same second current amplitude.

Evaluation and adjustment of time-varying pulse patterns in spinal cord stimulator systems are disclosed. Methods, systems, and computer-implemented algorithms are disclosed for determining time-varying pulses for a patient having an implantable stimulator device (ISD). At least one time-invariant stimuli pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce a time-varying pulse (TVP), and one or more measurements are made to determine the effectiveness of the TVP. The measurements may be objective and taken from the patient, and / or subjective and determined based on feedback from the patient. In one example, the objective measurements may include one or more features determined from electrospinal cord (ESG) signals detected by the ISD, which may include evoked composite action potentials. One or more measurements are used to determine a score of TVP, which is useful in selecting an optimal TVP for use with a patient, or in adjusting a modulation function applied to an ankylosing stimulation parameter.

The invention relates to the technical field of biomedical engineering and rehabilitation engineering, and discloses a functional electrical stimulation method and system based on physiological simulation and adaptive closed-loop feedback. The method comprises the following steps: calculating an ideal muscle activation curve based on a target trajectory; space-time asynchronous cooperative coding is executed, and a bionic stimulation pulse sequence is generated by simulating time asynchronism, space and intensity modulation and a multi-muscle cooperative time sequence; when stimulation is applied, the actual kinematics state and the muscle physiology state are monitored in real time through a sensor; and dynamically adjusting the internal parameters of the time-space asynchronous cooperative coding (T-S-C coding) based on the evaluation results of the trajectory error and the fatigue index to form a self-adaptive closed loop. According to the method, bionic coding and intelligent closed loop are combined, so that the problems of stiff movement, easy fatigue of muscles and poor control precision caused by traditional FES are fundamentally solved, and smooth, lasting and accurate personalized movement function rehabilitation is realized.

The present application relates to an implantable electrical stimulation system and a control method. The system comprises an electrode assembly, the electrode assembly comprising a stress release section for buffering stress transmitted from the tail end of the electrode assembly and at least one contact; the stimulation section and the stress release section are connected according to a bending angle. The system further comprises a processing unit configured to, based on the measurement of the activity in the brain region of the patient, control the pulse generator to generate stimulation pulses in a first time sequence; in a second time sequence, update the electrical stimulation scheme to a second stimulation parameter set based on the degree of coincidence between the feedback information of the activity in the brain region of the patient and the expected activity information; in a third time sequence, control the at least one contact remaining to the patient to electrically stimulate the patient to regulate the state of the patient to a normal state in the third stimulation parameter set. The present application combines the electrode structure conforming to the physiological characteristics and the adaptive pulse control.

An implantable stimulation system is provided having a stimulation unit coupled to a programmable controller, a stimulation circuit, and an electrode array disposed on a pair of flexible blades for selectively stimulating at least one pelvic nerve, such as a cavernous nerve. The implantable stimulation system may be programmed to run a first sequence of stimulation pulses, the first stimulation pulse sequence corresponds to a first pattern for inducing a rapid erection reaction to achieve sexual behavior and potential ejaculation, a second pattern for inducing a rapid erection reaction sufficient to facilitate a medical procedure, such as applying a catheter, a third neurological rehabilitation stimulation pattern for restoring neurotransmission to treat urinary incontinence and / or intestinal dysfunction, and / or a fourth penis rehabilitation pattern for reducing penis fibrosis. A method of operating the system is also provided.

The present application relates to wireless neural integrity monitoring systems and devices, which can include a control module configured to generate a payload request, wherein the payload request (i) requests a data payload from a sensor in a wireless neural integrity monitoring network and (ii) indicates whether a stimulation probe device is to generate a stimulation pulse, and a physical layer module configured to (i) wirelessly transmit the payload request to the sensor and the stimulation probe device or (ii) transmit the payload request to a console interface module and, in response to the payload request, (i) receive the data payload from the sensor and (ii) receive stimulation pulse information from the stimulation probe device, wherein the data payload includes data corresponding to an evoked response of a patient and wherein the evoked response is generated based on the stimulation pulse.

A computing system for programming stimulation parameters of a neuromodulation system is disclosed. The computing system includes a graphical user interface configured to display a multidimensional parameter space, wherein each axis of the parameter space corresponds to a respective stimulation parameter associated with stimulation pulses deliverable by the neuromodulation system, and render a target within the multidimensional parameter space, the target representing a set of stimulation parameters corresponding to coordinates along two or more axes of the multidimensional parameter space. The system further includes one or more user-operable controls configured to enable movement of the target within the multidimensional parameter space. Movement of the target within the multidimensional parameter space causes simultaneous adjustment of the stimulation parameters associated with the neuromodulation system along the two or more axes based on a position of the target in the multidimensional parameter space.

The invention relates to a control work efficiency closed-loop enhancement method and device based on brain cognitive load, and belongs to the technical field of electroencephalogram monitoring and vagus nerve stimulation, and the method comprises the steps: collecting original electroencephalogram signals of a forehead area FP1 / FP2 in real time, and carrying out band-pass filtering and segmentation processing to obtain electroencephalogram data in a data frame form; calculating a phase amplitude coupling index of two brain wave frequency bands according to a theta brain wave and gamma brain wave instantaneous amplitude sequence calculated by Hilbert transform; calculating a brain cognitive load index for evaluating a brain cognitive load state based on the phase amplitude coupling index; according to the brain cognitive load index, dynamically adjusting stimulation pulse parameters to perform vagus nerve stimulation; the brain cognition load is reduced, and the control work efficiency is enhanced; the silent period window with the set duration is reserved after the stimulation pulse is emitted, electroencephalogram data collection is only carried out outside the window, and interference of stimulation artifacts on electroencephalogram signals is avoided. According to the invention, nerve connection can be efficiently improved, and the control efficiency is improved.

Systems, devices and methods are provided for stimulating one or more cranial nerve(s) of a user. The systems and methods combine an electrical stimulation signal with an audio signal, such as music, white noise, ambient sound, filtered music, and the like. The combination of the nerve stimulation and the audio signal may be specifically designed to treat various diseases or disorders and / or for non-medical purposes, such as improving the general well-being of the user, reducing stress and the like. In certain embodiments, the electrical impulses comprise a burst stimulation and a tonic stimulation. The burst stimulation may comprise a burst of pulses. The bursts and / or the pulses may have frequencies that vary throughout the duration of the treatment.

A neuromodulation device for measuring an evoked response comprising a first electrode; a second electrode, wherein the first and second electrodes are alternately configured as a stimulation electrode; a sensing electrode for sensing an evoked response to a stimulus pulse; and a controller configured to measure an evoked response at the sensing electrode after a stimulus pulse at a first stimulation electrode configuration and after a stimulus pulse at a second alternate stimulation electrode configuration, and to add said pair of measurements.

Systems, devices, and techniques for analyzing evoked compound action potentials (ECAP)signals to evaluate and select an electrode combination. A method includes controlling, by processing circuitry, deliver of a plurality of stimulation pulses via at least one stimulation electrode combination, receiving, by the processing circuitry, evoked compound action potential (ECAP) signal information representing different ECAP signals evoked from respective stimulation pulses of the plurality of stimulation pulses and obtained from respective different sensing electrode combinations, selecting by the processing circuitry and based on the ECAP signal information, one electrode combination from the different sensing electrode combinations.

The present application relates to a kind of based on motor imagination trigger's electric stimulation synchronous closed loop multimodal neuroregulation system, belong to medical rehabilitation engineering and neural engineering technical field.The system includes: electroencephalogram signal acquisition and processing module, for real-time acquisition user sensory motor cortex electroencephalogram signal, and extract the event-related desynchronization features of motor imagination task in the electroencephalogram signal by time-frequency analysis model;Motor intention recognition and trigger module generates synchronous trigger signal;Functional electric stimulation module, through multi-channel electrode device drive surface electrode output electric stimulation pulse to target area, drive target action;Transcutaneous auricular vagus nerve electric stimulation module, output and motor intention duration synchronous stimulation pulse;Central control and synchronization module, for coordination control timing.Formed " intention recognition-synchronous control-assisted movement" complete closed loop, provides a kind of efficient, accurate, individualized neural engineering solution.

The application relates to the technical field of implantable medical devices, in particular to an active implantable pulse generator system generating bidirectional pulses and a control method. The system comprises a microcontroller, a bidirectional pulse generation circuit, a charge pump unit, a DA unit, an electrode lead and a sensing filter amplification unit. The bidirectional pulse generation circuit comprises two charging capacitor units and a plurality of discharge circuits. Under the control of the microcontroller, the two charging capacitor units are first charged by the charge pump unit, then the bidirectional pulse generation circuit can discharge a preset group number of bidirectional pulses to human tissues according to a preset voltage value and a preset pulse discharge time, so as to achieve the treatment purpose, and finally the charge in the human tissues is balanced by short-circuiting the discharge electrode, the charge accumulation effect caused by the unidirectional stimulation pulse is eliminated, and the problem that the charge accumulation effect causes damage to the human tissues is avoided.

This invention discloses a muscle stimulation modulation system and method based on real-time dynamic optimization, comprising: a real-time signal acquisition module for continuously acquiring multimodal physiological signals of the target limb, including at least electromyography (EMG) signals, joint kinematic angle signals, and neural electrical signals; a state assessment and prediction module for calculating real-time human state indicators based on the multimodal physiological signals, fusing historical state data, and generating future state trend prediction information through a time series prediction model; and a dynamic parameter optimization module for solving the optimal combination of stimulation parameters for the neuromuscular stimulator in real-time using an embedded optimization algorithm, based on the real-time human state indicators and state trend prediction information, with minimizing the objective function as the core. The stimulation parameter combination includes stimulation pulse intensity, frequency sequence, and waveform duty cycle. This invention enables better muscle stimulation modulation.

The invention relates to an electronic implant (100a,b) for implantation into the body of a living being and for monitoring and / or stimulating a bodily function, in particular a pacemaker for monitoring and / or stimulating the human heart, wherein the implant comprises: a housing (1a) which accommodates (i) electronics connected to an electrode (3a) configured to monitor bodily function via the electrode (3a) and / or to deliver a stimulation pulse to a body section (H), and (ii) a preferably rechargeable energy storage device (2a) for the long-term supply of electrical energy to the electronics; and an anchoring section (VA) for anchoring the electronic implant (100a,b) to the body section (H), wherein the anchoring section (VA) comprises an anchor (VA1) which is screwed into the body section (H) by a rotational movement, and a rotation lock which preferably extends in the direction of a rotational axis (RA) corresponding to the rotational movement and prevents a rotational movement of the anchor (VA1) in the opposite direction to the rotational movement after the anchor (VA1) has been screwed in.

The invention provides an electrical stimulation equipment output parameter adaptive adjustment method based on biofeedback, and the method comprises the steps: collecting a baseline interference response signal of a calibration stimulation pulse after the attachment of an electrode assembly is completed, and extracting the amplitude, rising edge slope, decay time, waveform distortion and other reference interference response characteristics. Interference response signals corresponding to the treatment stimulation pulses are collected in real time in the treatment process, and treatment process interference response characteristics corresponding to the reference characteristics are calculated. By comparing the deviation degree of the interference response characteristic and the reference characteristic in the treatment process, the current electrode contact state is dynamically evaluated, the corresponding local tissue impedance state is deduced, and grading recognition of the states such as good contact, general contact and abnormal contact is achieved. On the basis, according to the electrode contact state and the tissue impedance state, the safety upper limits of output parameters of the stimulation current, the stimulation voltage, the pulse conduction time and the waveform rise time are calculated in a self-adaptive mode.

A system for providing stimulation therapy to a patient includes stimulation generation circuitry, sensing circuitry, and processing circuitry. In one example, the processing circuitry can be configured to control the stimulation generation circuitry to generate at least one stimulation pulse via a stimulation electrode combination, control the switching circuitry to perform passive recharging of at least the stimulation electrode combination during a passive recharging period, control the switching circuitry to prevent passive recharging of at least the stimulation electrode combination during a passive recharging blanking period that is different from the passive recharging period, control the switching circuitry to stabilize the sensing circuitry during at least a first portion of the passive recharging blanking period, and control the sensing circuitry to measure an electrical signal during at least a second portion of the passive recharging blanking period.

The application provides a neural internal medicine rehabilitation training system and regulation method based on artificial intelligence, extracts the rhythm power of a stimulation pulse of a rehabilitation training device to a patient and the blood oxygen concentration of a target nerve point of the patient, classifies the efficiency of the remodeling level of the neural function in the rehabilitation training through the blood oxygen concentration and the rhythm power, and obtains a graded remodeling index of the neural function regulation in the rehabilitation training; determines the cortex excitability index of the patient in the neural internal medicine rehabilitation training through the motor evoked potential of the target patient muscle cortex, the stimulation frequency and the stimulation intensity of the stimulation pulse in the rehabilitation training device; multi-modal synergistically integrates the cortex excitability index and the graded remodeling index of the neural function regulation, obtains the neural regulation target parameter of the remodeling index in the rehabilitation training device, and then dynamically regulates the stimulation parameter in the rehabilitation training device based on the neural regulation target parameter. Based on the above scheme, multi-modal coupling regulation of the stimulation parameter in the rehabilitation training process can be realized.

This invention relates to the fields of digital therapy, intelligent medical devices, and applied artificial intelligence technologies, and more specifically to a closed-loop pain management method and system integrating diagnostic assistance and interference-resistant sensing. It includes: a wearable device comprising: a neuromodulation signal generator configured to generate neuromodulation stimulation pulses; a biosensor array physically integrated with the neuromodulation signal generator configured to sense physiological data indicating the user's autonomic nervous system activity; a controller configured to execute a time-division multiplexing protocol; a processor; and a non-transitory computer-readable storage medium associated with the processor for generating a diagnostic support report. This invention enables simultaneous effective neural stimulation and high-fidelity ANS signal acquisition on a single wearable device.

The application provides an implantable closed-loop neural stimulation system and a power consumption management method thereof. The power consumption management method comprises: determining first values of a plurality of characteristic parameters based on real-time collected electroencephalogram signals; when it is determined that the first values of the plurality of characteristic parameters meet a preset trigger condition of a neural abnormal event, switching a current working mode to a first working mode and applying an intervention stimulation pulse to the electrode; within a first time window after applying the intervention stimulation pulse, obtaining second values of the plurality of characteristic parameters; when it is determined that the first values and the second values of the plurality of characteristic parameters meet a preset condition, switching the first working mode to a second working mode, or adaptively adjusting parameters of the intervention stimulation pulse, wherein the power consumption of the first working mode is higher than that of the current working mode, and the power consumption of the second working mode is lower than that of the current working mode.