172 results about "Stimulus pulse" patented technology

Embodiments of the present disclosure may include a neuromodulation system. The neuromodulation system can include an implantable pulse generator configured to provide neuromodulation to a patient based on a sequence of neuromodulation programs. The implantable pulse generator can include alternately accessible memories. The alternately accessible memories can enable the implantable pulse generator to store a second neuromodulation program while providing neuromodulation according to a first neuromodulation program. The IPG can then transition from providing stimulation according to the first neuromodulation program to providing stimulation according to the second neuromodulation program without stopping stimulation. The neuromodulation system can include a parameter memory. Stimulation parameter updates can be written to the parameter memory. The value of the parameter memory can be used to determine the next stimulation pulse. The IPG can accordingly support pulse-to-pulse changes in stimulation parameters.

The invention discloses an electrical stimulation type nerve regeneration method based on calcium signal regulation and control, and relates to the technical field of electrical stimulation type nerve regeneration, and the method comprises the following steps: based on a Schwann cell population calcium signal response feature set, identifying whether the calcium ion concentration is in a microliter stage which breaks through a lowest activation threshold and does not reach a stable state; judging whether the target nervous tissue is in a calcium signal activation critical state or not based on the behavior mode change of the Schwann cell population; based on the judgment result of the calcium signal activation critical state, an electrical stimulation adjustment control instruction is generated in real time in combination with the calcium ion concentration fluctuation trend and Schwann cell population response characteristics, and the calcium ion concentration stability is optimized and the activation state is maintained by adjusting the electrical stimulation intensity, the electrical stimulation pulse width, the electrical stimulation waveform type and the electrical stimulation application time sequence. According to the method, the problem that a calcium signal is difficult to recognize and dynamically optimize in a microliter stage is solved, and precise maintenance of Schwann cell activation and improvement of nerve regeneration efficiency are realized.

An example of a system for delivering neurostimulation may include a programming control circuit and a user interface. The programming control circuit may be configured to generate stimulation parameters controlling delivery of the neurostimulation according to a pulse sequence. The pulse sequence may include a series of neurostimulation pulses and be defined by sequence parameters and one or more modulation functions each modulating an adjustable parameter selected from the sequence parameters. The user interface may be configured to set the pulse sequence to a tonic pulse sequence by determining an initial value for each adjustable parameter and set the pulse sequence to a modulated pulse sequence by selecting one or more adjustable parameters, determining a modulation function for each selected adjustable parameter, and applying the determined modulation function to that selected adjustable parameter to modulate the tonic pulse sequence.

Methods and systems for spinal cord stimulation (SCS) are disclosed. The methods and systems involve the use of electrode leads implanted within the spine of a patient to record nerve responses induced by a stimulus. The disclosed neural responses differ in various aspects from the electrical responses previously measured in the SCS context, such as stimulation artifacts and evoked compound action potentials (ECAPs). The disclosed neural responses typically occur at a later time after inducing the stimulation pulse. Another significant feature is that when the frequency of evoked stimulation is ultra-low, such as about 10 Hz or less, the disclosed neural response is most significantly observed at a consistent, relatively constant amplitude as a whole. The disclosed methods and systems may use these neural responses as indications of pain, treatment, and / or another clinically relevant dimension to guide / confirm stimulation placement, as well as feedback control for stimulation parameters.

The invention provides an electrode wire, a stimulator system and a computer readable storage medium, the electrode wire comprises a catheter, at least one electrode contact and a signal processing chip, each electrode contact is attached to the outer wall of the catheter, and each electrode contact is used for collecting a bio-electricity signal of a patient, and / or collecting the bio-electricity signal of the patient. Delivering electrical stimulation to the in vivo tissue of the patient according to the stimulation pulse signal; and the signal processing chip is arranged in the conduit. According to the invention, the signal processing chip is integrated in the electrode wire, so that the interference of external interference and stimulation pulse signals on bio-electricity signals is reduced.

Some embodiments include a system with a sensor with electrodes including an active electrode and a receiving electrode that is in physical contact with skin of a patient forming an electrical circuit with control electronics of a controller that can measure an electrical parameter using an active electrode and a receiving electrode within a closed loop electrical muscle stimulation system. A sense electrical pulse can be applied to the tissue using the sensor, an electrical parameter measured from the tissue, and a stimulation pulse applied to the tissue based at least in part on the measured electrical parameter. The stimulation is adjustably controlled by the controller to maintain a constant power output to the tissue based on the electrical parameter. A good is coupled to a computer readable medium configured to store usage data, the usage data relating to the patient's use of the good.

An electrode wire, a stimulator system, and a computer-readable storage medium. The electrode wire comprises a catheter, at least one electrode contact, and a signal processing chip, wherein each electrode contact is attached to the outer wall of the catheter, and each electrode contact is configured to at least one of the following: collect a bioelectric signal of an object, or, deliver electrical stimulation to tissue in the body of the object on the basis of a stimulation pulse signal; and the signal processing chip is arranged in the catheter, and the signal processing chip is electrically connected to the at least one electrode contact.

The present invention relates to a vagus nerve stimulation device. The vagus nerve stimulation device includes: a stimulation unit including an electrode worn on at least one of the left ear and the right ear to apply electrical stimulation to the vagus nerve of the external ear; a control unit for transmitting, to the stimulation unit, an electrical stimulation signal for generating electrical stimulation; and a mode selection unit through which a user selects a stimulation mode, wherein the mode selection unit includes a plurality of preset modes, each including an electrical stimulation signal that includes a stimulation pattern constituting the frequency of a stimulation pulse and the application type of a stimulation, the control unit stores information on an electrical stimulation signal corresponding to each mode and transmits the electrical stimulation signal corresponding to a mode selected by a user to the stimulation unit, and the mode selection unit includes a tension relaxation mode, a concentration mode, and a sleep induction mode. The present invention has a plurality of operation modes specialized for a specific purpose, thereby improving the effect of electrical stimulation through a mode selected according to the user's use purpose.

A system for providing stimulation therapy to a patient includes stimulation generation circuitry, sensing circuitry, and processing circuitry. In one example, the processing circuitry may be configured to control the stimulation generation circuitry to generate at least one stimulation pulse via a stimulation electrode combination, control the switching circuitry to perform passive recharge of at least the stimulation electrode combination during a passive recharge period, control the switching circuitry to prevent passive recharge of at least the stimulation electrode combination during a passive recharge blanking period different from the passive recharge period, control the switching circuitry to settle the sensing circuitry during at least a first portion of the passive recharge blanking period, and control the sensing circuitry to measure an electric signal during at least a second portion of the passive recharge blanking period.

The invention relates to a peripheral nerve stimulator. The peripheral nerve stimulator comprises a control device and at least two electrode leads, the control device is configured to generate an electrical stimulation pulse. The at least two electrode leads are electrically coupled to the control device and configured to be at least partially implanted within the patient to deliver electrical stimulation pulses to at least two neural branches, respectively, within the patient. The at least two electrode leads deliver electrical stimulation pulses to the at least two nerve branches of the nerve plexus at the same time, so that stimulation of the nerve branches is more comprehensive, and the stimulation effect of the peripheral nerve stimulator on the nerve plexus of peripheral nerves is enhanced.

The invention discloses an electrical stimulation device for cycle-by-cycle myoelectricity feedback regulation. An electrical stimulation circuit of the electrical stimulation device is used for releasing a stimulation pulse cycle signal; the electrical value acquisition circuit is used for acquiring electrical value signals of muscle nerves during a stimulation interval and feeding back the electrical value signals to the electrical stimulation circuit; the electric value acquisition circuit comprises an acquisition input module, a frequency selection amplification module and a charge discharge module; the acquisition end of the acquisition input module is connected with the frequency-selecting amplification module through the solid-state relay; a bleeder resistor of the charge discharge module is connected with the frequency-selecting amplification module through a solid-state relay; by adopting the solid-state relay, higher switching speed and silent switching can be realized, and the cycle-by-cycle quick switching of acquisition and stimulation is realized. And the electrical stimulation circuit adjusts electrical stimulation parameters and intensity of stimulation physiotherapy according to the feedback signal, so that the stimulation parameters are adjusted and controlled periodically one by one, and the physiotherapy effect is more accurate and more effective.

The invention provides a self-adaptive tremor judgment and stimulation pulse parameter adjustment method and system based on joint features. Belongs to the technical field of diagnosis and particularly relates to adaptive tremor judgment and pulse stimulation parameter adjustment. The method comprises the following steps: acquiring patient data in real time by using an accelerometer, and judging whether a tremor signal flag is 1 or not; when the tremor signal mark Flag is not equal to 1, processing the collected patient data to obtain time domain data and frequency domain data, performing adaptive tremor judgment based on joint features, and when the tremor signal mark Flag is judged to be a tremor signal, setting the tremor signal mark Flag to be 1, and calculating a tremor peak-to-peak value; and starting a pulse stimulation function, and adaptively adjusting pulse stimulation parameters according to the tremor peak-to-peak value. After the technical scheme is adopted, self-adaptive tremor judgment is accurately and quickly carried out in real time through time domain and frequency domain data, tremor related parameters are calculated, and pulse stimulation parameters are further adjusted according to the tremor related parameters.

The application discloses a cochlear implant multi-channel stimulation pulse half-wave detection system and method, and relates to the technical field of cochlear implants, in particular to a cochlear implant multi-channel stimulation pulse half-wave detection system and method. The system comprises a test board, a head piece and a speech processor, and further comprises a half-wave detection unit and a multi-channel collector. The test board comprises a receiving coil, a stimulator, a stimulation electrode and a test electrode terminal. The speech processor receives and processes sound signals and encodes the sound signals. The encoded signals are transmitted to the receiving coil through the head piece. After decoding processing by the stimulator, pulse signals with corresponding frequencies and current intensities are generated and transmitted to each stimulation electrode. The stimulation electrode is connected to the test electrode terminal. The test electrode terminal is connected to the multi-channel collector. The multi-channel collector is connected to the half-wave detection unit. The multi-channel collector combines n stimulation electrodes to transmit signals to the half-wave detection unit for half-wave detection. The application utilizes the multi-channel collector and the half-wave detection unit to realize automatic half-wave detection, reduce labor costs, and improve the efficiency and success rate of half-wave detection.

Systems and methods of wirelessly powered stimulators and implantable pulse generators that can generate stimulations with programmable amplitudes and RF spectrum control in the RF domain are described. An embodiment includes an implantable pulse generator that includes: an Rx antenna configured to receive a radio frequency (RF) signal: a demodulator coupled to the Rx antenna, the rectifier, and a source, and configured to control an output of a train of mini-pulses, based on the RF signal, each mini-pulse having a voltage amplitude and a pulse width (on-portion) smaller than a pulse width TO; and stimulation circuitry 250 coupled to receive the train of minipulses and deliver the train of mini-pulse to an electrode, where the train of mini-pulses to the electrode effectively corresponds to a stimulation pulse, having a pulse width TO and an amplitude that is a function of the pulse widths of the mini-pulses.

The invention discloses a rehabilitation system and method based on motor imagery electroencephalogram signals and eyeball tracking. The rehabilitation system comprises a signal acquisition module used for acquiring the motor imagery electroencephalogram signals and recording limb state information; the signal processing module is used for storing the collected motor imagery electroencephalogram signals, determining a motor intention through the motor imagery electroencephalogram signals and outputting a selection instruction; the eyeball tracking module is used for tracking an eyeball watching interface prompt instruction and cooperatively sending a treatment instruction with the selection instruction; and the electrical stimulator module is used for receiving the treatment instruction and outputting stimulation pulse current according to the treatment instruction. Through cooperation of real-time collection of non-invasive motor imagery signals and an eyeball tracking technology, the defects that a single motor imagery electroencephalogram signal is few in classification mode and low in real-time classification precision are overcome, rehabilitation training modes of different parts are autonomously selected according to the intention of a subject, the initiative and enthusiasm of a patient in the rehabilitation training process are improved, and the rehabilitation training efficiency is improved. The rehabilitation treatment effect of the patient is effectively improved.

Systems, devices, and techniques are described for adjusting electrical stimulation based on detected ECAPs. In one example, a medical device includes processing circuitry configured to control stimulation circuitry to deliver a first electrical stimulation pulse and sensing circuitry to detect, after delivery of the first electrical stimulation pulse, an ECAP signal. The processing circuitry may be configured to determine a characteristic value of the ECAP signal, determine an ECAP differential value that indicates whether the characteristic value of the ECAP signal is one of greater than a selected ECAP characteristic value or less than the selected ECAP characteristic value, determine, based on the ECAP differential value, a gain value, determine, based on the gain value, a parameter value that at least partially defines a second electrical stimulation pulse, and control the stimulation circuitry to deliver the second electrical stimulation pulse according to the parameter value.

Systems, devices, and techniques for adjusting electrical stimulation based on a posture state of a patient are described. For example, processing circuitry is configured to control delivery of a first informed stimulation pulse defined by at least a first value of an informed stimulation parameter, control delivery of a control stimulation pulse to a patient, the control stimulation pulse defined by at least a first value of a control stimulation parameter, determine a characteristic value of the ECAP signal elicited from the control stimulation pulse, receive, from a sensor, a posture state signal representing a posture state of the patient, and adjust, based on the characteristic value of the ECAP signal and the posture state signal, the first value of the informed stimulation parameter to a second value of the informed stimulation parameter.

The present invention aims to solve the technical problems that in the current electromyographic biofeedback therapeutic instrument technical solutions, only one electrode is provided, which can only realize one function of electromyographic acquisition or electric stimulation pulse output, and two independent electrodes are provided, which cannot directly acquire the electromyographic signal when the electric stimulation pulse is output. The present invention provides an electromyographic feedback electric stimulation control system and a control method. The control system includes an electrode, an electric stimulation pulse module, a pulse sampling module, a signal preprocessing module, an electromyographic signal acquisition and processing module and a system control module. The electric stimulation pulse sampling module acquires the current electric stimulation signal according to a preset sampling ratio, and then eliminates the electric stimulation signal by subtraction operation on the signal acquired by the device. Through one electrode, electric stimulation pulse output and electromyographic acquisition input can be performed simultaneously, and the system setting is simpler.

The present invention discloses a fully parallel vector outer product calculation operation method based on electrochemical random access memory, including constructing a memory array with electrochemical random access memory and its gate-select transistor as basic units, and a corresponding random pulse update method. Among them, the conductivity change of the electrochemical random access memory is highly linearly related to the number of stimulation pulses. When no stimulation pulse is applied, the device channel conductance remains unchanged, showing non-volatile characteristics. Through random pulse programming, the device's conductance update and online training can be performed in situ, the vector outer product calculation is completed in parallel, and the calculation result is stored in the device's conductance, and subsequent network in-memory calculation acceleration is performed, avoiding additional data handling, and effectively reducing operation complexity and device programming delay. In addition, this solution can be extended to the network training paradigm related to the Hebbian learning rule to accelerate the training process of related algorithms.

A method of conducting operations for an IPG adapted to provide electrical pulses to tissue of a patient for medical therapy is provided. The IPG provides the medical therapy according to pulse parameter data executed according to an execution path. The method can include identifying a root node repeated within the execution path of a first set of the pulse parameter data, identifying a stimulation pulse pattern repeated in the first set between occurrences of the root node, replacing the repeated pattern with (a) a single instance and a recurrence count or (b) a pointer to a reference pattern to generate a second set of the pulse parameter data, and communicating the second set between the external controller and the IPG and / or storing the second set within a memory of the IPG.

Some embodiments include a system with a sensor with electrodes including an active electrode and a receiving electrode that is in physical contact with skin of a patient forming an electrical circuit with control electronics of a controller that can measure an electrical parameter using an active electrode and a receiving electrode within a closed loop electrical muscle stimulation system. A sense electrical pulse can be applied to the tissue using the sensor, an electrical parameter measured from the tissue, and a stimulation pulse applied to the tissue based at least in part on the measured electrical parameter. The stimulation is adjustably controlled by the controller to maintain a constant power output to the tissue based on the electrical parameter. A good is coupled to a computer readable medium configured to store usage data, the usage data relating to the patient's use of the good.

A system (10) for neuromodulation and / or neurostimulation for treating a mammal, comprising at least:-at least one control unit (12) configured and arranged to provide stimulation data; -at least one stimulation unit (14) configured and arranged to provide stimulation pulses; -at least one real-time monitoring unit (18); -at least one signal processing unit (16); wherein the system (10) is configured and arranged for controlling blood pressure wherein the stimulation unit (14) is configured to comprise a lead (20), and wherein the lead (20) is capable and configured to provide stimulation to the spinal cord at a site T9-L1.

Methods, systems, and computer-implementable algorithms for determining time-varying pulses for a patient with an implantable stimulator device (ISD) are disclosed. At least one time-invariant tonic stimulation pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce a time-varying pulse (TVP), and one or more measurements are made to determine the effectiveness of the TVP. The measurements can be objective and taken from the patient, and / or subjective and determined based on feedback from the patient. In one example, the objective measurements can include one or more features determined from an epidural spinal cord electrogram (ESG) signal detected by the ISD, which can include an evoked compound action potential. The one or more measurements are used to determine a score for the TVP, which is useful in selecting the best TVP for use with the patient, or for adjusting the modulation function applied to the tonic stimulation parameters.

This application relates to the fields of biomedical engineering and rehabilitation engineering technology, and discloses a functional electrical stimulation method and system based on physiological simulation and adaptive closed-loop feedback. The method includes: calculating an ideal muscle activation curve based on a target trajectory; performing spatiotemporal asynchronous co-coding to generate a biomimetic stimulation pulse sequence by simulating temporal asynchrony, spatial and intensity modulation, and multi-muscle synergistic timing; simultaneously applying stimulation while monitoring the actual kinematic state and muscle physiological state in real time using sensors; and dynamically adjusting the internal parameters of the spatiotemporal asynchronous co-coding (T-S-C coding) based on the evaluation results of trajectory error and fatigue index to form an adaptive closed loop. This application, by combining biomimetic coding with an intelligent closed loop, fundamentally solves the problems of motion stiffness, muscle fatigue, and poor control precision caused by traditional FES, achieving smooth, sustained, and precise personalized motor function rehabilitation.

Embodiments of the invention provide a system and method for delivering a stimulating treatment or relief to a patient. The system includes a pair of stimulating electrodes coupled to an article that can be coupled to a patient to deliver stimulation controlled through a wired or wireless link. The system includes a controller that can generate and apply stimulating pulses to the pair of stimulating electrodes based on a stimulation program and signals or data. The system includes a sensor coupled to the controller and the article and a user interface that enables a user to remotely view or exchange information through the link and monitor and set or reconfigure the stimulating pulses. In some embodiments, the article includes a brace assembly that can be a brace, a strut, a sleeve, a sling, a garment, a wrap, or a band.

This invention describes techniques for a medical device that delivers electrical stimulation using a current or voltage regulator with an adjustable principal amplitude. An exemplary method includes: receiving user input indicating a desired current amplitude via a programmer for an electrical stimulator; and selecting a first fractional adjustment or a second fractional adjustment as a target adjustment for achieving the desired current amplitude. A neural modulation system includes: a first electrode; a second electrode; a stimulation generator configured to deliver a first stimulation pulse to the first electrode and a second stimulation pulse to the second electrode, wherein a first current amplitude of the first stimulation pulse is a first fraction of the principal amplitude and a second current amplitude of the second stimulation pulse is a second fraction of the principal amplitude; and a processor configured to: generate initial instructions for the stimulation generator to perform: (i) deliver the first analog pulse based on the first fraction of the principal amplitude, and (ii) deliver the second stimulation pulse based on the second fraction of the principal amplitude, receiving user input including the desired current amplitude. The processor determines, based on the desired current amplitude, the adjustment of the first current amplitude of the first stimulation pulse to be required, and determines a target adjustment based at least in part on a comparison of the desired current amplitude with the main amplitude, wherein the processor is further configured to: (A) determine an adjustment to at least the first fraction as the target adjustment, or (B) determine the following as the target adjustment: (i) an adjustment to the main amplitude, and (ii) an adjustment to at least the second fraction relative to the main amplitude adjustment, and, based at least in part on the target adjustment, generate adjustment instructions for the stimulation generator to deliver the first stimulation pulse with the desired current amplitude and the second stimulation pulse with approximately the same second current amplitude.

Evaluation and adjustment of time-varying pulse patterns in spinal cord stimulator systems are disclosed. Methods, systems, and computer-implemented algorithms are disclosed for determining time-varying pulses for a patient having an implantable stimulator device (ISD). At least one time-invariant stimuli pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce a time-varying pulse (TVP), and one or more measurements are made to determine the effectiveness of the TVP. The measurements may be objective and taken from the patient, and / or subjective and determined based on feedback from the patient. In one example, the objective measurements may include one or more features determined from electrospinal cord (ESG) signals detected by the ISD, which may include evoked composite action potentials. One or more measurements are used to determine a score of TVP, which is useful in selecting an optimal TVP for use with a patient, or in adjusting a modulation function applied to an ankylosing stimulation parameter.

The invention relates to the technical field of biomedical engineering and rehabilitation engineering, and discloses a functional electrical stimulation method and system based on physiological simulation and adaptive closed-loop feedback. The method comprises the following steps: calculating an ideal muscle activation curve based on a target trajectory; space-time asynchronous cooperative coding is executed, and a bionic stimulation pulse sequence is generated by simulating time asynchronism, space and intensity modulation and a multi-muscle cooperative time sequence; when stimulation is applied, the actual kinematics state and the muscle physiology state are monitored in real time through a sensor; and dynamically adjusting the internal parameters of the time-space asynchronous cooperative coding (T-S-C coding) based on the evaluation results of the trajectory error and the fatigue index to form a self-adaptive closed loop. According to the method, bionic coding and intelligent closed loop are combined, so that the problems of stiff movement, easy fatigue of muscles and poor control precision caused by traditional FES are fundamentally solved, and smooth, lasting and accurate personalized movement function rehabilitation is realized.

The present application relates to an implantable electrical stimulation system and a control method. The system comprises an electrode assembly, the electrode assembly comprising a stress release section for buffering stress transmitted from the tail end of the electrode assembly and at least one contact; the stimulation section and the stress release section are connected according to a bending angle. The system further comprises a processing unit configured to, based on the measurement of the activity in the brain region of the patient, control the pulse generator to generate stimulation pulses in a first time sequence; in a second time sequence, update the electrical stimulation scheme to a second stimulation parameter set based on the degree of coincidence between the feedback information of the activity in the brain region of the patient and the expected activity information; in a third time sequence, control the at least one contact remaining to the patient to electrically stimulate the patient to regulate the state of the patient to a normal state in the third stimulation parameter set. The present application combines the electrode structure conforming to the physiological characteristics and the adaptive pulse control.