35 results about "Neural stimulation" patented technology

Essentially, the present invention comprises an assembly for transvascular stimulation from within an artery, enabling nerve stimulation to one or more regions of the autonomic nervous system around an artery by a bipolar guidewire having a distal end of a suitable shape, and this stimulation can be performed rapidly or for mapping purposes.

An implantable device that deliver neural stimuli to a neural pathway of a patient 108 in order to evoke neural responses 130 using implanted stimulation electrodes. A control unit configured to control the stimulus source to provide a first neural stimulus according to a first stimulation set. Then using one or more shorting pulse parameters of a first stimulation set, connect the stimulation electrodes. Measure an intensity of an evoked neural response in a captured signal window subsequent to a second neural stimulus. The captured signal window includes an artefact resulting from the first neural stimulus. The one or more shorting pulse parameters are configured to minimise a magnitude of the artefact in the captured signal window.

This invention discloses an electrode lead and a nerve stimulation system. The electrode lead includes a stimulation segment, a connecting segment, and an intermediate segment. The stimulation segment includes several stimulation contacts and at least one filter, one end of which is electrically connected to at least one stimulation contact. The intermediate segment includes multiple core wires, each core wire including at least one first transmission line for transmitting stimulation signals and at least one second transmission line for transmitting interference signals. The connecting segment includes several connection contacts and a consumption module. The two ends of the first transmission lines are electrically connected to the connection contacts and the filter, respectively, and the two ends of the second transmission lines are electrically connected to the consumption module and the filter, respectively. The electrode lead of this application can prevent interference signals from entering the stimulation segment, ensuring the stability of the stimulation signal output, improving the MRI compatibility of the electrode lead, and enhancing the therapeutic effect and patient comfort. In particular, it can prevent abnormal heating of the stimulation contacts, thereby avoiding damage to the patient.

The present application relates to the technical field of nerve stimulation, and discloses a closed-loop vagus nerve precise blocking system and method based on physiological signal feedback, comprising a physiological signal monitoring unit for acquiring physiological signals of an individual in real time; a data acquisition and analysis module connected with the physiological signal monitoring unit, for receiving and analyzing the physiological signals, judging the physiological state of the individual, and generating a feedback signal; a stimulation device unit for outputting an electric stimulation signal based on the feedback signal, so that the vagus nerve stimulation reaches a functional block state; and a closed-loop feedback unit connected with the data acquisition and analysis module and the stimulation device unit, for dynamically adjusting the stimulation parameters according to the feedback signal and controlling the electric stimulation signal of the stimulation device in real time. Through the real-time monitoring and real-time feedback mechanism, the present application realizes functional block of the vagus nerve, and ensures the accuracy, safety and individualization of the inhibition operation.

The present invention relates to the technical field of neural stimulation, and specifically relates to a non-invasive spinal cord stimulator for upper limb motor function recovery, comprising a cervical spinal cord pulse control unit, an electrode connection unit, a motion monitoring unit, a wireless communication unit, a speech unit, a paradigm decision unit, an electrode array unit, and an artificial intelligence unit. In the present invention, the non-invasive spinal cord stimulator acts on a specific cervical spinal cord segment by means of non-invasive cervical spinal cord stimulation technology, inducing the reconstruction of a spinal cord neural network, strengthening synaptic connection, treating upper limb motor dysfunction of paralyzed individuals, and achieving upper limb motor function recovery.

The application provides a closed-loop control system based on neural energy consumption optimization, comprising: a neural state evaluation module configured to perform feature extraction on the collected brain deep field potential signals of the target brain area to construct a neural feature vector, and calculate a current neural abnormality degree according to the neural feature vector; a stimulation parameter generation module configured to generate a plurality of candidate stimulation parameter combinations; a neural state prediction module configured to calculate a predicted neural abnormality degree according to an established neural state prediction model, the current neural abnormality degree and the candidate stimulation parameter combination; an energy cost calculation module configured to calculate an energy cost according to the candidate stimulation parameter combination; a neural state optimization module configured to establish an optimization objective function according to the current neural abnormality degree, the predicted neural abnormality degree and the energy cost, and determine an optimized stimulation parameter combination that minimizes the value of the optimization objective function; and a neural stimulation control module configured to perform stimulation control according to the optimized stimulation parameter combination.

This invention relates to an intraoperative nerve localization system for thoracic sympathectomy, belonging to the field of minimally invasive surgical assistance and medical information processing technology. During thoracoscopic surgery, this system identifies and analyzes candidate regions of the thoracic sympathetic nerve by acquiring intraoperative thoracoscopic images and patient physiological signals. It also verifies the sympathetic nerve properties of the target structure by combining the physiological functional responses induced by intraoperative nerve stimulation. Based on this, the system fuses and calculates the image structural information and functional response information to generate the localization reliability of the thoracic sympathetic nerve, providing the surgeon with localization references and safety prompts for thoracic sympathectomy. This system enables real-time, objective localization of the thoracic sympathetic nerve during surgery, reducing reliance on surgeon experience, lowering the risk of mis- or missed sympathectomy, and improving the safety and consistency of thoracic sympathectomy, thus possessing high clinical application value.

A device for auricular nerve stimulation, comprising: a reusable module (1) comprising: - a stimulation circuit (4) configured to generate electrical stimulation signals, - a control unit (2) configured to control a stimulation parameter of the electrical stimulation signals, such as the intensity, frequency, pulse width and / or duration of the electrical stimulation signals, - a communication unit (5) configured to allow data exchange between the control unit (2) and an external device (6), and - a power management unit (3) configured to regulate and distribute electrical power to the stimulation circuit, the control unit (2) and the communication unit (5), in a plurality of single-use modules comprising: - a fixation module (7) configured to be fixed to a user's body, - a power supply module (8),- an electrode module (9) comprising at least two electrodes, and - optionally a sensor module (10), wherein each of the single-use modules (7, 8, 9, 10) and the reusable module (1) comprise mechanical connection means for mechanically connecting each of the single-use modules (7, 8, 9, 10) to the reusable module (1) so that it can be released.

The present invention essentially comprises a catheter that enables both nerve stimulation for mapping purposes in one or more regions of the autonomic nervous system around an artery, and denervation of the mapped one or more regions when those mapped regions are considered targets.

The present application relates to the field of liquor brewing, and particularly to a solid fermentation liquor brewing method for reducing the content of higher alcohols; the method constructs a mechanism for targeted inhibition of isobutanol, isoamyl alcohol and n-propyl alcohol and promotion of the generation of ethyl hexanoate; accurate quantification and comparison by gas chromatography-mass spectrometry show that the core of the method is to significantly reduce higher alcohols and improve key aroma substances; the method of the present application blocks the synthesis of higher alcohols without changing the proportion of traditional flavor substances of liquor, guarantees the liquor yield, reduces the nervous stimulation after drinking, and improves the metabolic clearance rate of ethanol in the body.

A neural stimulation device is disclosed, including: a pulse generator, an evoked compound action potential (ECAP) sensor, and a neural stimulation controller. The neural stimulation controller instructs the ECAP sensor to sense an ECAP after a pulse is generated by the pulse generator within a first pulse generation cycle, adjust an amplitude of a pulse generated within a second pulse generation cycle in response to a peak-to-peak value of the ECAP being not in a comfort range, and adjust, according to an expected peak-to-peak value, an amplitude of a pulse generated within a third pulse generation cycle in response to a peak-to-peak value of the ECAP after the pulse is generated within the second pulse generation cycle being still not in the comfort range. The expected peak-to-peak value is in the comfort range including an amplitude dimension of the pulse and a peak-to-peak value dimension of the ECAP.

The application provides an implantable closed-loop neural stimulation system and a power consumption management method thereof. The power consumption management method comprises: determining first values of a plurality of characteristic parameters based on real-time collected electroencephalogram signals; when it is determined that the first values of the plurality of characteristic parameters meet a preset trigger condition of a neural abnormal event, switching a current working mode to a first working mode and applying an intervention stimulation pulse to the electrode; within a first time window after applying the intervention stimulation pulse, obtaining second values of the plurality of characteristic parameters; when it is determined that the first values and the second values of the plurality of characteristic parameters meet a preset condition, switching the first working mode to a second working mode, or adaptively adjusting parameters of the intervention stimulation pulse, wherein the power consumption of the first working mode is higher than that of the current working mode, and the power consumption of the second working mode is lower than that of the current working mode.

The application provides a non-invasive nerve stimulation system and method based on time coherent modulation, and relates to the technical field of nerve stimulation.The method comprises a data communication module, an intelligent control module, a first stimulation path module, a second stimulation path module, a facial electrode module, a safety monitoring module, a head beam module and a manual recorder module.The data communication module is connected with the intelligent control module.The first stimulation path module and the second stimulation path module are both connected with the intelligent control module.The first stimulation path module and the second stimulation path module are both connected with the facial electrode module.The facial electrode module, the safety monitoring module, the head beam module and the manual recorder module are electrically connected.The manual recorder module is connected with the intelligent control module.The first stimulation path module and the second stimulation path module are used for generating two high-frequency electric stimulation signals.The facial electrode module is used for applying the two high-frequency electric stimulation signals to the projection area of the buccal pterygopalatine ganglion.The head beam module is used for wearing and fixing.

The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region.

The application discloses a control method and device of a hypoglossal nerve stimulation device, equipment and a medium, the method comprises: acquiring a physiological characteristic signal for characterizing the breathing state of a detected object; based on the delay corresponding to the physiological characteristic signal, a breathing state space model of the physiological characteristic signal is constructed, so as to compensate for the delay when estimating the target respiratory phase of the detected object at the current time; based on the breathing state space model, the physiological characteristic signal is filtered by a specified filter to estimate the target respiratory phase; determine whether the target respiratory phase is within the preset stimulation window; if yes, output the stimulation signal; if not, return to the step of acquiring the physiological characteristic signal. Thus, by introducing delay compensation when constructing the breathing state space model, the accuracy of the stimulation signal output is improved. In addition, through real-time target respiratory phase estimation and preset stimulation window judgment, the breathing state of the detected object is tracked, and the accuracy of the respiratory phase synchronous control is improved.

Disclosed is an implantable device for controllably delivering neural stimuli. The device comprises a pulse generator configured to deliver neural stimuli via one or more stimulation electrodes to a neural pathway of a patient. The device comprises measurement circuitry configured to capture signal windows from signals sensed on the neural pathway by one or more measurement electrodes, wherein the measurement circuitry comprises a configurable compound amplifier configured to amplify the captured signal windows. The device is configured to control the pulse generator to deliver a neural stimulus according to one or more stimulus parameters, measure a characteristic of an evoked neural response in an amplified captured signal window subsequent to the delivery of the neural stimulus, determine a feedback variable from the measured characteristic of the evoked neural response and adjust the one or more stimulus parameters so as to maintain the feedback variable at or near a target value.

This invention provides a collaborative control method based on consciousness impairment assessment and monitoring and synchronous neural stimulation. The method includes: an eye-tracking monitoring and analysis system extracting eye-tracking feature data from eye-tracking signals using image preprocessing and eye-tracking feature extraction algorithms; a server-side management system combining scale assessments and eye-tracking feature data, utilizing a multi-source data fusion assessment algorithm to output the patient's consciousness state assessment results and stimulation parameter information; a neural correlation electrical stimulator receiving the stimulation parameter information and using a timing synchronization control algorithm to synchronously initiate neural electrical stimulation with the eye-tracking monitoring and analysis system; and the server-side management system dynamically adjusting the consciousness state assessment results and stimulation parameter information based on post-stimulation eye-tracking response characteristics and stimulation parameter feedback, reusing the multi-source data fusion assessment algorithm to form a closed-loop control. This invention achieves timing synchronization and command closed-loop through a collaborative linkage algorithm, ensuring efficient collaborative operation of multiple modules and adapting to complex clinical scenarios such as ICUs and rehabilitation departments.

The present disclosure relates to a composition for skin improvement comprising beta-sitosterol and betulin. It was confirmed that the composition has excellent effects of skin-soothing and relieving skin irritation by reducing skin nerve stimulation-inducing factors, increasing the expression of moisturizing-related factors, increasing skin absorption, improving skin permeation, and inhibiting mast cell activity, and thus can be effectively used in cosmetics, quasi-drugs, etc. for skin improvement.

The application relates to the technical field of nerve stimulation, and discloses an application method of transcutaneous cervical vagus nerve electrical resistance arrest, which is implemented by using an electrical resistance arrest device to make the vagus nerve reach an inhibition state; the electrical resistance arrest device comprises an electrode unit, a stimulation unit and a physiological monitoring unit; the electrode unit and the physiological monitoring unit are respectively electrically connected with the stimulation unit; the electrode unit comprises two electrode pads, the electrode pads are respectively arranged in specified areas, and the two electrode pads are parallel and free of distortion; the stimulation unit comprises a current regulator, a frequency generator and a power supply, the current regulator is used for outputting a current intensity in a sine wave mode; the frequency generator is used for setting frequency parameters of the electrode unit; the physiological monitoring unit comprises a sensor, a data collector and a display device, the sensor is used for detecting physiological indexes, and data is transmitted to the display device. The application first proposes that the vagus nerve function arrest is realized through the electrical resistance arrest device, and reversible nerve inhibition is realized through accurate electrode positioning and parameter setting.

The application discloses a kind of epilepsy closed loop intelligent processing method based on micro machine learning.The method comprises: the pre-processing of input electroencephalogram signal;Lightweight one-dimensional convolutional neural network model is used to analyze and judge the electroencephalogram feature after processing, and when the seizure state is identified, the treatment control module is triggered to output pulse signal, guides nerve stimulation device to intervene epilepsy, and realizes closed loop treatment.The present application is based on embedded platform, with the advantages of fast response, efficient calculation, wearable, etc., suitable for real-time epilepsy monitoring and intervention in family and mobile scene, effectively improve the intelligent and personalized level of epilepsy management.

A wearable neural stimulation and sensing device includes a headband worn on a head. The surface of the headband has electrode mounting recesses that can flexibly mount a stimulation electrode and a sensing electrode. The stimulation electrode includes a shallow stimulation electrode and a deep stimulation electrode that can respectively perform trigeminal nerve stimulation (TNS) and temporal interference brain stimulation (TIBS) to implement non-invasive electrical stimulation for shallow and deep brain regions. The sensing electrode, used for electrical impedance tomography, monitors the physiological data of brain activity in real time. A control unit adjusts the electrical stimulation parameter of the stimulation electrode and the measurement parameter of the sensing electrode. A processing unit processes the obtained physiological data. The present invention features precise stimulation, compact size, and portability, making it suitable for the treatment and monitoring of neurodegenerative diseases, thereby improving the quality of life of patients.

An example system includes a collar; a first stimulating electrode array positioned on the collar and configured to delivery stimulation therapy to a patient; a second stimulating electrode array being positioned on the collar and configured to deliver stimulation therapy to the patient; a sensor array being positioned on the collar and configured to detect one or more features indicative of laryngeal muscle activity of the patient; and a controller configured to control stimulation therapy to be delivered via the first stimulating electrode array and the second stimulating electrode array.

This invention discloses an electrocoagulation device integrating bioelectrical impedance identification function, including a left clamp handle, a right clamp handle, and a left and right clamp head controlled by the opening and closing of the left and right clamp handles, respectively. The front ends of the left and right clamp heads are provided with interlocking teeth. The left clamp head is provided with a nested multifunctional electrode, including a first outer electrode, an insulating ceramic tube disposed inside the first outer electrode, and an inner core electrode disposed inside the insulating ceramic tube. The first outer electrode and the inner core electrode constitute a pair of opposing electrodes for impedance detection and nerve stimulation. The right clamp head is provided with a second outer electrode, and the first and second outer electrodes constitute a pair of opposing electrodes for high-frequency electrocoagulation. This invention enables the coordinated operation of high-frequency electrocoagulation and bioelectrical impedance detection functions on the same instrument, and allows for safe switching between different operating modes through a switchable electrical connection structure.

This invention belongs to the field of physical therapy technology for Parkinson's disease, and provides a non-invasive closed-loop feedback vagus nerve electrical stimulation system for the prevention and treatment of Parkinson's disease. The system includes: a high-frequency electrical stimulator hardware subsystem, transcutaneous nerve stimulation electrodes, a respiratory and heart rate signal acquisition and closed-loop feedback subsystem, and a high-frequency electrical stimulator software subsystem. This invention uses kilohertz stimulation pulses to bidirectionally modulate the vagus nerve, activating afferent C fibers and initiating the anti-inflammatory neural pathway of locus coeruleus noradrenergic neurons, thus alleviating central inflammation. Simultaneously, it blocks A and B efferent fibers, inhibiting mediated α-synuclein retrograde axonal transport. Through multimodal physiological signal monitoring and embedded intelligent algorithms, it achieves real-time, closed-loop, and personalized control of stimulation parameters and automatic switching of stimulation modes, optimizing efficacy and improving safety. Through adhesive electrodes and acquisition devices, it achieves completely non-invasive, wearable, and home-based treatment.

A method for treatment of incontinence by targeted nerve stimulation where a signal generator is provided to generate a stimulation signal to modulate a patient's voiding disorder having the symptoms of abnormal urgency, incontinence or retention. A stimulator targets a portion of the patient's nervous tissue where the nervous tissue may be the patient's saphenous nerve, the patient's lateral plantar nerve or the patient's medial plantar nerve. The stimulation signal is applied to the patient's nervous tissue to activate the nervous tissue in order to modulate the voiding disorder.

An electrode assembly comprises a base with first and second arms extending from opposite sides of the base, and which, in combination, define an arc. First and second electrically conductive electrodes extend along the inner surface of the first and second arms. Each electrode can comprise a single length of foil can or multiple discrete foil segments. The foils are electrically isolated from each other. Electrical wires electrically connect the foils electrically to a signal monitor. When the electrode assembly is applied to a nerve, the foils, in combination, substantially surround the nerve, with the first and second electrodes being on opposite sides of the nerve from each other. Also disclosed is a method of using the electrode assembly to monitor a nerve during a lumbar spinal surgery while the patient is anesthetized and paralyzed.

There is provided a method and implantable device for controlling a neural stimulus, the neural stimulus being defined by an artefact mitigation status. The method comprises generating a first neural stimulus for delivery to neural tissue, sensing a first signal subsequent to the first neural stimulus, generating a second neural stimulus for delivery to the neural tissue, and sensing a second signal subsequent to the second neural stimulus. The method further comprises determining an artefact mitigation measure (AMM) effect level based on the first sensed signal and the second sensed signal, and setting, in response to comparing the AMM effect level with an AMM effect threshold, the artefact mitigation status of a third neural stimulus to active.

This cochlear implant includes a neural stimulator that stimulates the auditory nerve connected to the cochlea. The neural stimulator includes: a first coil unit that receives power, data, or both from an external apparatus; a first magnet unit attached to the external apparatus by magnetic force and including two or more pairs of stimuli (magnetic poles) arranged so as to have magnetic fields that cancel out each other; a neural stimulation processing unit that processes neural stimulation signals; and a neural stimulation electrode that stimulates the auditory nerve on the basis of the neural stimulation signals.

This invention relates to a brain region localization magnetic resonance imaging (fMRI) data processing method based on neural stimulation target optimization. It acquires functional magnetic resonance imaging (fMRI) data from subjects, extracts signal response sequences of each brain region before and after neural stimulation through time-domain analysis, and identifies brain regions with characteristic response time windows based on differences in response delay. Based on the neural feedback relationship between the cortex and deep structures, it detects delayed oscillation features in cortical signals to identify potential regulatory pathways in the thalamus and other deep brain regions, thereby locating indirect stimulation targets that cannot be directly imaged. It performs decoupling analysis of cerebral blood flow signals and neural activation signals on candidate brain regions; when blood flow fluctuations are detected in a region but synchronous neural activation is lacking, it is identified as a spurious activation area and excluded. This invention calculates the time-delay correlation between the stimulation sequence and brain region signals using an improved cross-correlation integral function, and combines a nonlinear attenuation term to suppress high-frequency noise interference, making the estimation of brain region response delay more stable and repeatable.