185 results about "Neural stimulation" patented technology

Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and / or experience relating to the same. Some systems and methods generate a biphasic stimulation waveform that includes a plurality of pulses with alternating leading phases. Some systems and methods vary one or more parameters of the stimulation waveform to correlate with a characteristic of the user. Example characteristic of the user include a phase of a tremor exhibited by the user and a respiratory cycle of the user. For some systems and methods, the stimulation waveform includes a plurality of burst with each burst ramping up in amplitude. For some systems and methods, the stimulation waveform is delivered during a time period that includes an on-cycle portion and an off-cycle portion with the stimulation waveform only being delivered during the on-cycle portion of the time period.

Adjustable auricular nerve stimulation devices, and associated systems and methods, are disclosed herein. A representative device for delivering an electrical signal to a subject includes a signal delivery element including at least two electrodes configured to deliver the electrical signal to a first portion of the subject's ear. The device also includes a retention element configured to engage a second portion of the subject's ear. The device further includes an adjustment mechanism permitting movement of the signal delivery element relative to the retention element to place the at least two electrodes in contact with the first portion of the subject's ear.

A system and method for targeted stimulation with a tracheal phrenic nerve stimulation device that can include: performing an initialization routine of a stimulation module that determines a set of stimulation parameters, the initialization routine comprises: cycling through electrode groupings, detecting a response in a respiratory signal for each electrode grouping, and determining a select electrode grouping as part of the stimulation parameters; and operating a stimulation module using the set of stimulation parameters.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

The invention relates to the technical field of medical instruments, in particular to a nerve stimulation method and device based on adaptive posture detection. The method comprises the following steps: in a posture calibration stage, acquiring data through an acceleration sensor, and carrying out smoothing processing by utilizing an optimized Kalman filtering algorithm; according to the calculated resultant acceleration standard deviation, distinguishing a dynamic posture from a static posture, correspondingly establishing a resultant acceleration standard deviation interval for the dynamic posture, and establishing an included angle interval between three axes and a horizontal plane for the static posture; in the posture detection stage, by calculating the resultant acceleration standard deviation of real-time data, the dynamic and static types are judged firstly, and then the resultant acceleration standard deviation is matched with the corresponding calibration interval to recognize the specific posture. And finally, dynamically adjusting nerve stimulation parameters according to the identified postures.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate at least one of tremor feedback, external data, predictive adaptation, or long-term monitoring data. The device may be configured as a wrist worn device to stimulate three nerves to provide tremor reduction.

The invention provides a brachial plexus and exoskeleton cooperative control method and system based on a brain-computer interface, and relates to the field of intelligent control. The method comprises the steps that electroencephalogram signals and upper limb electromyographic signals of a target object during motor imagery are collected; predicting the motion intention of the target object through a neural network based on the electroencephalogram signals and the upper limb electromyographic signals; based on the motion intention, determining a target brachial plexus branch according to a preset motion intention and brachial plexus mapping rule; generating a nerve stimulation control instruction and an exoskeleton cooperative control instruction based on the target brachial plexus branch and the motion intention; and according to the nerve stimulation control instruction, performing electrical stimulation on the target brachial plexus branch to drive the corresponding muscle to contract, and meanwhile, according to the exoskeleton cooperative control instruction, controlling the upper limb exoskeleton to apply assistance to the corresponding joint. The method and the device are used in the cooperative control process of the brachial plexus and the exoskeleton, and the technical problem of inaccurate control in the existing limb control process based on neural signals is solved.

The invention relates to a minimally invasive implantable frontal lobe brain-computer interface method and device, and the method comprises the steps: constructing an individualized brain three-dimensional model according to CT and MRI image data of a patient, presetting an optimal nasal implantation path, and carrying out the implantation of the patient through a nose under the dual guidance of a nasal endoscope and a three-dimensional navigation system, constructing a skull base passage through minimally invasive trimming of a nasal cavity / paranasal sinus structure, and performing real-time matching and overlapping on an endoscope view and the three-dimensional model by using a rigid body transformation algorithm to display the position of a surgical instrument; windowing at a preset target point, implanting the flexible electrode array into a target brain region according to a planned depth and angle through a controllable propulsion mechanism, and establishing a neural signal acquisition or stimulation interface; intelligent mode recognition is carried out on the collected neural signals, the intention or brain state of the user is decoded, and corresponding neural stimulation or feedback signals are generated. According to the method, accurate, safe and minimally invasive clinical intervention is realized through a full-chain technical scheme of individualized planning, real-time navigation, minimally invasive implantation and biological integration, and the application value of a brain-computer interface technology is remarkably improved.

The invention discloses an implantable nerve stimulation in-vivo power supply closed-loop regulation method based on OSA treatment. The method comprises the following steps: initializing power supply; the state acquisition module acquires physiological signals related to the OSA in real time and transmits the physiological signals to the in-vivo MCU control module; the in-vivo MCU control module receives and processes the physiological signal, executes a multi-parameter fusion closed-loop adjustment algorithm, performs risk assessment on the current breathing state, dynamically adjusts the output power level of the DC-DC power management module according to a risk assessment result, matches the requirement of electrical stimulation, and acts on the electrical stimulation module; and the in-vivo MCU control module performs information interaction with the in-vitro MCU control module through Bluetooth communication. According to the implantable nerve stimulation in-vivo power supply closed-loop adjustment method based on OSA treatment, physiological features can be collected in real time, a power supply strategy is automatically adjusted, and the treatment effect is improved.

Essentially, the present invention comprises an assembly for transvascular stimulation from within an artery, enabling nerve stimulation to one or more regions of the autonomic nervous system around an artery by a bipolar guidewire having a distal end of a suitable shape, and this stimulation can be performed rapidly or for mapping purposes.

According to an aspect of the present inventive concept there is provided a system for determining an estimate of an anatomy of neural tissue of a subject. The system comprises an electrode arrangement comprising a plurality of electrodes, wherein different electrodes in the plurality of electrodes are configured to be arranged in different electrode locations adjacent the neural tissue, wherein the plurality of electrodes is configured to receive a plurality of stimulation signals, a sensor arrangement configured to generate indications of changes in at least one of a neural activity or a physiological activity in response to the stimulation signals and a processing unit, configured to receive data representing relations between the plurality of stimulation signals and the indications of changes in the neural activity or physiological activity, wherein the processing unit is configured to generate the estimate of the anatomy of the neural tissue of the subject.

The invention provides albizia flower compound essential oil with sleep aiding and depression relieving functions and a preparation method of the albizia flower compound essential oil, and relates to the technical field of aromatherapy and natural product application. The compound essential oil takes an albizia flower low-temperature two-stage extract as a core carrier and is compounded with various functional essential oil components such as bitter orange leaf essential oil, FCF bergamot essential oil and Egypt nymphaea tetragona original essence, and the compound essential oil is prepared through three core innovations of albizia flower carrier synergistic technology, multi-channel nerve regulation design and safety strengthening design. The technical problems that existing sleep-aiding essential oil is single in effect and high in potential nerve irritation and the bioavailability of albizia flower flavonoid glycoside is low are solved. Experimental verification shows that the compound essential oil can shorten the sleep latency period by 52% and reduce the anxiety score by 47%, can cooperatively regulate the GABA energy system, 5-hydroxytryptamine secretion and hypothalamus-pituitary-adrenal axis through an olfaction-nerve reflex path, realizes efficient anxiety resistance, deep sleep promotion and emotion balance, and is suitable for people with various anxiety insomnia and emotional disorder.

Differential charge-balancing can be used in high-frequency neural stimulation. For example, a neural stimulation apparatus can have first and second electrodes configured to be coupled proximate to a nerve fiber to implement a neural stimulation procedure. A neural stimulation circuit can be electrically coupled to the first and second electrodes. The neural stimulation circuit can apply stimulation currents to the nerve fiber through the first and second electrodes during a first stimulation phase of the neural stimulation procedure. The neural stimulation circuit can also apply a modified stimulation current to the nerve fiber through the first electrode during a second stimulation phase of the neural stimulation procedure. The modified stimulation current can be generated based on a difference between (i) a voltage at the first electrode, and (ii) a reference voltage derived from voltages on the first and second electrodes.

An implantable device that deliver neural stimuli to a neural pathway of a patient 108 in order to evoke neural responses 130 using implanted stimulation electrodes. A control unit configured to control the stimulus source to provide a first neural stimulus according to a first stimulation set. Then using one or more shorting pulse parameters of a first stimulation set, connect the stimulation electrodes. Measure an intensity of an evoked neural response in a captured signal window subsequent to a second neural stimulus. The captured signal window includes an artefact resulting from the first neural stimulus. The one or more shorting pulse parameters are configured to minimise a magnitude of the artefact in the captured signal window.

The invention discloses a traditional Chinese medicine composition for improving memory and concentration and a preparation method thereof, and relates to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12-22 parts of fructus alpiniae oxyphyllae, 15-25 parts of radix astragali, 8-16 parts of ginseng, 10-20 parts of walnuts, 10-20 parts of radix puerariae, 6-14 parts of cornel pulp, 8-18 parts of radix rehmanniae, 10-20 parts of Chinese wolfberry fruits, 15-25 parts of spina date seeds, 8-16 parts of polygala tenuifolia, 6-14 parts of rhizoma acori graminei and 4-10 parts of earthworms. According to the traditional Chinese medicine composition for improving memory and concentration and the preparation method of the traditional Chinese medicine composition, polygala ketone contained in polygala tenuifolia can specifically up-regulate hippocampal BDNF expression and doubly repair memory pathway damage caused by alcohol, volatile asarone in acorus gramineus can penetrate a blood brain barrier, and the volatile asarone is compatible with polygala tenuifolia, so that the nerve stimulation threshold value of a single component can be reduced, the intelligence promoting effect can be improved, and the traditional Chinese medicine composition can be used for improving memory and concentration. The earthworm extract can inhibit the activity of lactic dehydrogenase in the brain, and the synergistic effect mechanism of the polygala tenuifolia, the rhizoma acori graminei and the earthworm can also play a role in preventing and treating the Alzheimer's disease.

The utility model relates to the technical field of medical equipment, and provides a nerve stimulation acupuncture needle, which comprises a needle seat, a needle core, a conductor wire, a needle core, a needle core, a needle core, a needle core, a needle core, a needle core, a needle core, a needle core, a needle core and a needle core, the needle core and the conductor wire are electrically connected, and the needle seat is of an insulating material structure; the cannula is provided with a through hole, the cannula is arranged on the needle base and the needle core in a sleeving mode through the through hole, and scale marks are arranged on the outer side wall of the cannula and used for displaying the insertion depth of the needle core; the needle base and the needle core are slidably arranged along the through hole, and scale reference marks are arranged at the positions, close to the scale marks, of the needle base. During use, the needle core is slowly inserted into the subcutaneous part of a patient, the sleeve abuts against the skin of the patient, and at the moment, the needle base slides along the through hole of the sleeve. The scale mark pointed by the scale reference mark on the needle seat is the current depth of the needle core inserted into the subcutaneous part of the patient, and the sleeve with the scales helps a doctor to master the insertion depth. Meanwhile, the nerve stimulation acupuncture needle can be connected into a nerve stimulator, and a target nerve is searched through the nerve stimulator.

Systems and methods of the present disclosure are directed to neural stimulation via audio and visual stimulations. The combination and / or sequence of audio and visual brain stimulations can adjust, control or otherwise manage the frequency of the neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain, while mitigating or preventing adverse consequences on a cognitive state or cognitive function that stems from sleep deprivation. In doing so, the present systems and methods can reduce sleep fragmentation, improve sleep quality, and slow the progression of cognitive decline in a subject with Alzheimer's disease and MCI.

A method and external device for providing sub-perception stimulation to a patient via an implanted stimulator device is disclosed. A stimulation parameter is determined for the patient that provides sub-perception stimulation to address a symptom of the patient. A schedule is determined to provide scheduled bolus stimulation, where each bolus includes a duration during which stimulation is applied to the patient according to the stimulation parameter, and where the scheduled boluses are separated by an off time when no stimulation is provided to the patient. Preferably, a first duration of each scheduled bolus is (3) minutes or more, and a second duration of each off time is (30) minutes or more. By selecting an option on the external device, additional boluses can be provided as needed in addition to the scheduled boluses, although providing such additional boluses is subject to a lockout period.

The present technology pertains to a vagus nerve stimulation apparatus and a vagus nerve stimulation method capable of easily and appropriately giving electric stimuli to a vagus nerve. A vagus nerve stimulation apparatus according to the present technology is provided with: a first electrode disposed in the vicinity of a stimulation site which is a site at which a vagus nerve of a user is to be stimulated; a second electrode disposed in the vicinity of the stimulation site; and a stimuli control unit for controlling the application of a first electrical signal having a first frequency to the first electrode and the application of a second electrical signal having a second frequency different from the first frequency to the second electrode. The present technology can be applied to, for example, headphones and earphones.

Methods and systems for providing electrical stimulation to a patient's spinal cord using electrode leads implanted in the patient's spinal column are described. Embodiments involve cycling between durations during which stimulation is actively applied and durations when no stimulation is applied. The stimulation can be configured such that pain relief washes in during the active stimulation duration and continues for some part of the duration when no stimulation is being applied. Eventually the pain relief may wash out. The washout time may be modeled, so that stimulation may be resumed before the pain relief washes out. The stimulation may be below the patient's perception threshold.

This invention discloses an electrode lead and a nerve stimulation system. The electrode lead includes a stimulation segment, a connecting segment, and an intermediate segment. The stimulation segment includes several stimulation contacts and at least one filter, one end of which is electrically connected to at least one stimulation contact. The intermediate segment includes multiple core wires, each core wire including at least one first transmission line for transmitting stimulation signals and at least one second transmission line for transmitting interference signals. The connecting segment includes several connection contacts and a consumption module. The two ends of the first transmission lines are electrically connected to the connection contacts and the filter, respectively, and the two ends of the second transmission lines are electrically connected to the consumption module and the filter, respectively. The electrode lead of this application can prevent interference signals from entering the stimulation segment, ensuring the stability of the stimulation signal output, improving the MRI compatibility of the electrode lead, and enhancing the therapeutic effect and patient comfort. In particular, it can prevent abnormal heating of the stimulation contacts, thereby avoiding damage to the patient.

The invention relates to the technical field of medical monitoring, and particularly discloses an AI anesthesia depth monitoring system combined with nerve stimulation, which is characterized in that standardized electrical stimulation is applied to a motor nerve pathway of a patient in a general anesthesia state, and spinal nerve electrical signals and limb movement signals induced by the standardized electrical stimulation are synchronously acquired and analyzed; performing time-frequency transformation on the neural signal to extract a dominant oscillation mode of the neural signal, and generating a neural rhythm disorder degree characteristic value by quantizing frequency jitter and amplitude attenuation; analyzing the time sequence collaboration of the motion signal and the stimulation and the motion form, and generating a motion response deviation characteristic value; fusing the two features into a two-dimensional feature vector, inputting the two-dimensional feature vector into a pre-trained anesthesia depth classification model, and directly outputting an objective anesthesia depth level; and finally, starting grading early warning according to the grade change trend and generating a monitoring report.

The present application relates to the technical field of nerve stimulation, and discloses a closed-loop vagus nerve precise blocking system and method based on physiological signal feedback, comprising a physiological signal monitoring unit for acquiring physiological signals of an individual in real time; a data acquisition and analysis module connected with the physiological signal monitoring unit, for receiving and analyzing the physiological signals, judging the physiological state of the individual, and generating a feedback signal; a stimulation device unit for outputting an electric stimulation signal based on the feedback signal, so that the vagus nerve stimulation reaches a functional block state; and a closed-loop feedback unit connected with the data acquisition and analysis module and the stimulation device unit, for dynamically adjusting the stimulation parameters according to the feedback signal and controlling the electric stimulation signal of the stimulation device in real time. Through the real-time monitoring and real-time feedback mechanism, the present application realizes functional block of the vagus nerve, and ensures the accuracy, safety and individualization of the inhibition operation.

The utility model discloses a skull implantable stimulation device, which comprises a stabbing nerve stimulator and at least one fixing part, the thorn nerve stimulator is used for sending out a nerve stimulation signal; the fixing part is arranged on a curved surface formed by the curvature k1 in the first direction and the curvature k2 in the second direction, and the nerve stimulator is fixed to the skull through the fixing part; wherein the curvature k1 is the curvature in the skull sagittal direction anatomical data; the curvature k2 is the curvature in the skull coronal direction anatomical data. After the skull implantable stimulation device is implanted, the fixing part can be attached to the skull, so that the scalp tension caused after the stimulation device is implanted is reduced.

The invention relates to a brain region positioning magnetic resonance data processing method based on nerve stimulation target optimization, and the method comprises the steps: obtaining the functional magnetic resonance imaging data of a subject, extracting the signal response sequence of each brain region before and after nerve stimulation through time domain analysis, and determining the brain region with a characteristic response time window according to the response delay difference; the method comprises the following steps: detecting delayed oscillation characteristics in a cortex signal based on a neural feedback relationship between a cortex region and a deep structure to determine potential regulatory pathways of thalamus and other deep brain regions so as to position indirect stimulation targets which cannot be directly imaged; decoupling analysis of cerebral blood flow signals and nerve activation signals is carried out on the candidate brain area, and when it is detected that blood flow fluctuation exists in the area but synchronous nerve activation is lacked, it is judged that the area is a pseudo activation area and excluded; according to the method, the time delay correlation degree between the stimulation sequence and the brain region signal is calculated through the improved cross-correlation integral function, and the high-frequency noise interference is suppressed in combination with the nonlinear attenuation item, so that the estimation of the brain region response delay is more stable and repeatable.

A system comprising an output device, a brain oscillation monitor, and one or more processors. The output device is configured to output an audio signal for audio stimulation of the patient, and a visual pattern for video stimulation of the patient. The brain oscillation monitor is configured to generate feedback indicative of a response to the audio stimulation and the visual stimulation. The one or more processors are configured to determine a target frequency for the audio stimulation and the visual stimulation. The one or more processors are further configured to cause constructive interference of the audio stimulation and the visual stimulation output by the output device at the target frequency, by modifying at least one of a phase of the visual pattern or an amplitude of onsets for the visual pattern, relative to the audio signal, according to the feedback from the brain oscillation monitor.

An adaptor for anchoring wire lead components of electrical nerve stimulation assemblies, the adaptor incorporating a left jaw; the adaptor further incorporating a right jaw; the adaptor further incorporating a left arm having a proximal end, a distal end, and a right side; the adaptor further incorporating a right arm; the adaptor further incorporating an upper left channel opening rightwardly; the adaptor further incorporating an upper right channel opening leftwardly; the adaptor further incorporating a lower left channel opening rightwardly; the adaptor further incorporating a lower right channel opening leftwardly; and the adaptor further incorporating a hinge which is fixedly attached to or formed wholly with the proximal ends of the left arm, the right arm, the left jaw, and the right jaw.

A method for alleviating post-infection symptoms of COVID-19 in a subject employs vestibular nerve stimulation (VeNS). Upon or after onset of symptoms, an electrode is placed into electrical contact with the subject proximate to a location of the subject's vestibular system. A current source delivers VeNS to the electrode in a sequence of current pulses at a subsensory frequency for a treatment session of approximately 30 minutes to approximately 60 minutes to alleviate post-COVID-19 symptoms including fatigue, malaise, headache, and difficulty concentrating.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

The invention provides a nerve stimulation electrode based on a titanium nitride film and a preparation method thereof. The method comprises the steps that at a first temperature, a metal lamination layer is sputtered and deposited through a magnetron reactive sputtering technology so as to form stimulation sites on a lower-layer insulating substrate, the metal lamination layer at least comprises a titanium nitride film, and the first temperature is lower than 100 DEG C; coating a high polymer material, and performing curing treatment at a second temperature higher than 300 DEG C to form an upper insulating substrate, and recrystallizing the titanium nitride film in the curing treatment process; the upper insulating substrate is patterned to expose the stimulation sites. According to the scheme disclosed by the invention, the nerve stimulation electrode based on the titanium nitride film, which is high in performance and reliability, can be prepared at a relatively low temperature.