398 results about "Neural stimulation" patented technology

The present application pertains to the technical field of neural stimulation. Disclosed are a temporal interference-based closed-loop multimodal neural stimulation system and method. The system comprises a temporal interference stimulation system, an electroencephalography-functional near-infrared spectroscopy sampling system, and an upper-level control system. The temporal interference stimulation system utilizes a beat-frequency electric field generated by two sets of electrodes to precisely stimulate a specified brain region. The electroencephalography-functional near-infrared spectroscopy sampling system is a bimodal collector coupling electroencephalography and functional near-infrared spectroscopy, including two parts: signal extraction and correlation analysis, and analyzes stimulation effects and adjusts stimulation schemes by integrating unified brain signal data that combines the temporal precision of EEG and the spatial precision of fNIRS. The upper-level control system includes bimodal fusion model computation, graph convolutional neural network prediction, and stimulation scheme formulation. The present application addresses the problems that traditional stimulation methods lack a closed-loop regulation system, have no means for calibration and optimization, and require a long adaptation period between the stimulation scheme and the user, thus being disadvantageous for applications.

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

The invention relates to the technical field of nerve stimulation, in particular to a noninvasive spinal nerve stimulator for upper limb movement function recovery, which comprises a neck marrow pulse control unit, an electrode connection unit, a movement monitoring unit, a wireless communication unit, a voice unit, a normal form decision-making unit, an electrode array unit and an artificial intelligence unit. The cervical medullary segment non-invasive nerve electrical stimulation technology acts on a specific cervical medullary segment, the reconstruction of a spinal cord neural network is induced, synaptic connection is enhanced, the upper limb movement dysfunction of paralyzed people is solved, and the recovery of the upper limb movement function is realized.

Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and / or experience relating to the same. Some systems and methods generate a biphasic stimulation waveform that includes a plurality of pulses with alternating leading phases. Some systems and methods vary one or more parameters of the stimulation waveform to correlate with a characteristic of the user. Example characteristic of the user include a phase of a tremor exhibited by the user and a respiratory cycle of the user. For some systems and methods, the stimulation waveform includes a plurality of burst with each burst ramping up in amplitude. For some systems and methods, the stimulation waveform is delivered during a time period that includes an on-cycle portion and an off-cycle portion with the stimulation waveform only being delivered during the on-cycle portion of the time period.

The invention discloses a closed-loop vagus nerve stimulation system acting on depression, which comprises a data acquisition unit, a core analysis unit, a signal regulation and control unit and a nerve stimulation unit, and is characterized in that patient heart rate data and combined treatment data of a depression patient are acquired through the data acquisition unit; the core analysis unit is used for analyzing the influence function of the medicine and electrotherapy combined treatment on the physical signs of the patient so as to obtain an optimal collaborative treatment scheme and a corresponding electrotherapy design scheme, and the signal regulation and control unit is used for carrying out targeted parameter regulation and control on the electrotherapy signal and outputting an electrotherapy optimization signal; personalized electrotherapy is carried out on the depression patient through the nerve stimulation unit, targeted parameter regulation and control are carried out on the closed-loop vagus nerve stimulation system according to the personalized illness state of the patient, and the actual application accuracy of the closed-loop vagus nerve stimulation system is improved by analyzing the combined action mechanism of electrical stimulation and drug therapy. More comprehensive and effective depression auxiliary monitoring and diagnosis and treatment effects are realized.

An electrode assembly (preferably in the form of a nerve cuff) comprises a base with first and second arms extending from opposite sides of the base, and which, in combination, define an arc. First and second electrically conductive electrodes extend along the inner surface of the first and second arms. Each electrode can comprise a single length of foil can or can comprise multiple discrete foil segments. The foils are electrically isolated from each other. Electrical wires, which are in electrical communication with the each of the foils, extend from the nerve cuff and are adapted to be electrically connected to a signal monitor. When the nerve cuff is applied to a nerve, the foils, in combination, substantially surround the nerve, with the first and second electrodes being on opposite sides of the nerve from each other. Also disclosed is a method of using the nerve cuff to monitor a nerve during a lumbar spinal surgery while the patient is anesthetized and paralyzed.

Adjustable auricular nerve stimulation devices, and associated systems and methods, are disclosed herein. A representative device for delivering an electrical signal to a subject includes a signal delivery element including at least two electrodes configured to deliver the electrical signal to a first portion of the subject's ear. The device also includes a retention element configured to engage a second portion of the subject's ear. The device further includes an adjustment mechanism permitting movement of the signal delivery element relative to the retention element to place the at least two electrodes in contact with the first portion of the subject's ear.

The invention relates to the technical field of nerve stimulation, in particular to a miniature implantable spinal nerve stimulator which comprises an electrode, a stimulator body and a control system. The electrode, the stimulator body and the control system operate in a matched mode, the electrode and the stimulator body are integrally connected and arranged without an extension wire, the stimulator body sinks to the lower portion of a spine spinous process, and an upper end wire is flush with other spinous processes of the spine; the control system comprises a main controller unit, a radio frequency unit, a channel decoding unit, a transmitter unit, a power divider / synthesizer unit, a main power supply unit, an energy storage unit, an electrical stimulation unit, an array electrode unit and a posture recognition unit. The miniature spinal cord nerve stimulator is implanted in the early stage of spinal cord injury by combining spinal cord nerve decompression operation and spinal fixation operation, the size of the stimulator is small, the electrode lead is short, no implant protrusion phenomenon exists after operation, the golden window period after spinal cord injury is fully utilized, favorable conditions are created for spinal cord injury rehabilitation, and the rehabilitation effect is improved.

Devices and / or methods for treating sleep disordered breathing may include stimulation of a single nerve, multiple nerves, as well as other tissues relating to upper airway patency.

A system and method for targeted stimulation with a tracheal phrenic nerve stimulation device that can include: performing an initialization routine of a stimulation module that determines a set of stimulation parameters, the initialization routine comprises: cycling through electrode groupings, detecting a response in a respiratory signal for each electrode grouping, and determining a select electrode grouping as part of the stimulation parameters; and operating a stimulation module using the set of stimulation parameters.

The invention provides a closed-loop nerve synchronous regulation and detection system, and belongs to the technical field of neuroscience. The system comprises an electrophysiological regulation subsystem which is used for implementing nerve stimulation regulation on a detected object, has a filtering and amplifying preprocessing function and can receive and send out nerve regulation signals; the signal processing subsystem is used for receiving the preprocessed neural signals, sending out control signals for the electrophysiological regulation and control subsystem and synchronously analyzing and processing the preprocessed neural signals; and the neural multi-electrode is used for detecting an original neural signal. According to the system, a neural signal analysis method based on the power spectrum entropy of wavelet packet decomposition node reconstruction signals is used for calculating and analyzing neural signals collected by multiple neural electrodes, and then closed-loop regulation and control are carried out by comparing the neural signals with a set threshold value. According to the system, the experiment operation in the nerve regulation and control work is simplified, and the experiment efficiency is improved.

The invention provides a special endoscope thyroid nerve monitoring bipolar electrode, and relates to the technical field of medical apparatuses and instruments. A radio frequency output electrode is arranged in a functional electrode unit and used for applying high-frequency current to carry out tissue cutting and blood coagulation, and a nerve stimulation electrode is used for applying low-frequency current to carry out nerve stimulation and monitoring. The two electrodes work cooperatively, the impedance detection electrode can collect a voltage signal after the low-frequency current passes through the tissue, and the impedance modeling unit converts the collected voltage signal to obtain an impedance value. The position positioning module determines the position of a working point between the two electrode ends. In the operation process, the initial impedance value of the working point at the current position serves as the type impedance to judge the tissue type of the working point, tissue cutting is conducted along with a radio frequency output electrode, the impedance value change of the working point at the current position is monitored, and the tissue cutting result is judged in combination with the previously determined tissue type. And the safety and the overall efficiency of the surgical operation are improved.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

The invention relates to the technical field of medical instruments, in particular to a nerve stimulation method and device based on adaptive posture detection. The method comprises the following steps: in a posture calibration stage, acquiring data through an acceleration sensor, and carrying out smoothing processing by utilizing an optimized Kalman filtering algorithm; according to the calculated resultant acceleration standard deviation, distinguishing a dynamic posture from a static posture, correspondingly establishing a resultant acceleration standard deviation interval for the dynamic posture, and establishing an included angle interval between three axes and a horizontal plane for the static posture; in the posture detection stage, by calculating the resultant acceleration standard deviation of real-time data, the dynamic and static types are judged firstly, and then the resultant acceleration standard deviation is matched with the corresponding calibration interval to recognize the specific posture. And finally, dynamically adjusting nerve stimulation parameters according to the identified postures.

The invention discloses a minimally invasive flexible piezoelectric-triboelectric hybrid nanometer nerve stimulation device and application thereof.The middle layer of the nerve stimulation device is a PVDF / TMCM-MnCl3 composite nanofiber membrane, Au electrodes are evaporated on the two faces of the PVDF / TMCM-MnCl3 composite nanofiber membrane, two gold wire or copper wire electrodes are connected with the Au electrodes respectively, and the two gold wire or copper wire electrodes are connected with the Au electrodes respectively. The surface of the Au electrode is subjected to primary packaging by adopting a PU waterproof film, and the surface of the PU waterproof film is subjected to secondary packaging by adopting PDMS. The nerve stimulation device is used for conventional treatment of SIRS. The vagus nerve stimulator can generate an adjustable current up to 0.85 mA under programmable ultrasonic driving, and can be directly used for VNS. The PTNG is ultrasonically driven in vitro to assist the VNS in treating lipopolysaccharide-induced SIRS rats, release of inflammatory factors such as TNF-alpha, IFN-gamma and IL-1beta can be effectively reduced, cytokine storm is relieved, and multi-organ tissue damage and dysfunction are relieved, so that the survival hope is improved.

The utility model relates to bipolar electric coagulation forceps and an electric coagulation device capable of achieving intraoperative nerve electrophysiological stimulation and monitoring. The bipolar electric coagulation forceps comprise a forceps body and a switch assembly. Wherein the forceps body comprises a first body and a second body; the switch assembly is selectively and electrically connected with the first body and the second body. The switch assembly is provided with a first gear, a second gear and a third gear. By switching the switch assembly to the third gear, the stimulation current flows through the other one of the first body and the second body to form a loop, so that nerve stimulation operation can be performed on a surgical site to stimulate nerves so as to enable the nerves to transmit electrophysiological signals sufficient to be monitored, and compared with fixed site stimulation in the prior art, the operation efficiency is greatly improved. And a stronger electrophysiological signal can be obtained, so that whether a nerve exists at an operation part or not is accurately judged, and the nerve is prevented from being damaged due to misoperation.

A bilateral auricular nerve stimulation system of the vagus nerve, which comprises two adjustable stimulator devices (4) in each ear respectively where each one comprises a support piece (5) with a curved temple (6); three or more cathodal stimulation electrodes simultaneously, with a first and second electrode (1, 2) that fit into the cymba and cavum respectively and a third electrode (3) that fits into the external auditory canal (EAC), where all electrodes are connected to one or more anodes (32), and have means of adjustment to their area of action; a photoplethysmography biosensor (PPG) (7) located at the free end of the curved temple (6), and; control means inside the support piece (5); where the system comprises a connection and synchronization cable between both stimulator devices.

An apparatus for neural stimulation, the apparatus comprising a head device configured to be worn on a head of a user, the head device comprising a light-emitting device configured to provide photic entertainment to the user, and a control module connected to the light-emitting device and configured to operate the light-emitting device through receipt of one or more stimulatory commands, and a computing device communicatively connected to the head device, the computing device comprising a processor, and a memory communicatively connected to the processor, the memory containing instructions configuring the processor to receive user data, wherein the user data comprises information relating to a neural state of a user, generate the one or more stimulatory commands as a function of the user data wherein generating or more stimulatory commands includes determining the neural state of the user, and transmit one or more stimulatory commands to the head device.

In an illustrative embodiment, methods and system for increasing coagulation potential and / or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.

Systems, devices, and methods for promoting a patient's volume return to the heart and cardiac pre-load by inducing constriction of at least a portion of the splanchnic bed of the patient are described herein. Constriction of at least a portion of the splanchnic bed is induced via electrical stimulation to splanchnic nerve fibers of one or more splanchnic nerves. Electrical stimulation to splanchnic nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the splanchnic nerve fibers.

The invention discloses an ultrasound-electroencephalogram multifunctional electrode for deep brain stimulation. The multifunctional electrode sequentially comprises a matrix microtube, a PMUT electrode for deep brain ultrasonic stimulation and an SEEG electrode for electroencephalogram signal detection from inside to outside. The ultrasonic-electroencephalogram multifunctional electrode for deep brain stimulation has the functions of fixed-point ultrasonic nerve stimulation and in-situ electroencephalogram signal detection, provides powerful support for closed-loop nerve stimulation in the future, and meanwhile has the advantages of being simple in preparation process, low in manufacturing cost and the like.

This disclosure describes, among other embodiments, systems and related methods for selecting electrode combinations to be used during nerve pacing procedures. A first set of electrode combinations of a nerve pacing system, such as a phrenic nerve pacing system for diaphragm activation, may be mapped (or tested) to determine the location of the electrode combinations relative to a target nerve. Once the general location of the target nerve is known, a more localized second set of electrode combinations may be tested to determine the most suitable electrode combinations for nerve stimulation. At various stages of the mapping process, electrode combinations that are non-optimal may be discarded as candidates for use in a nerve pacing procedure. The systems and methods described herein may allow for the selection of electrode combinations that are most suitable for stimulation of the left and right phrenic nerves during diaphragm pacing.

The invention relates to the technical field of nerve stimulation, and discloses a directional electrode and a nerve stimulation system. The directional electrode comprises an electrode main body; the electrode contact is arranged on the electrode main body, the electrode contact is provided with a plurality of contact surfaces, each contact surface can be independently used as a stimulation source and / or a signal acquisition point, and at least two contact surfaces in the plurality of contact surfaces respectively face different directions. The electrode contacts have a plurality of stimulation directions and / or a plurality of signal acquisition directions. According to the directional electrode disclosed by the embodiment of the invention, a more comprehensive coverage range of a stimulating electric field and / or signal acquisition can be provided.

Disclosed are methods and devices for analysing signal windows captured subsequent to delivered neural stimuli and for providing a quality score for each signal window. The quality score is indicative of how closely the captured signal window resembles, or how likely that the captured signal window contains, an ECAP. The quality score may be provided to a process supervising a feedback loop of the closed-loop neural stimulation device delivering the stimuli and capturing the signal windows to ensure the delivered stimuli are appropriate. For example, if the score falls below a predetermined threshold, the supervisor may take a mitigation action to prevent inappropriate adjustment to the intensity of the delivered stimuli by the feedback loop, such as suspending operation of the feedback loop.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate at least one of tremor feedback, external data, predictive adaptation, or long-term monitoring data. The device may be configured as a wrist worn device to stimulate three nerves to provide tremor reduction.

The invention provides a brachial plexus and exoskeleton cooperative control method and system based on a brain-computer interface, and relates to the field of intelligent control. The method comprises the steps that electroencephalogram signals and upper limb electromyographic signals of a target object during motor imagery are collected; predicting the motion intention of the target object through a neural network based on the electroencephalogram signals and the upper limb electromyographic signals; based on the motion intention, determining a target brachial plexus branch according to a preset motion intention and brachial plexus mapping rule; generating a nerve stimulation control instruction and an exoskeleton cooperative control instruction based on the target brachial plexus branch and the motion intention; and according to the nerve stimulation control instruction, performing electrical stimulation on the target brachial plexus branch to drive the corresponding muscle to contract, and meanwhile, according to the exoskeleton cooperative control instruction, controlling the upper limb exoskeleton to apply assistance to the corresponding joint. The method and the device are used in the cooperative control process of the brachial plexus and the exoskeleton, and the technical problem of inaccurate control in the existing limb control process based on neural signals is solved.

The invention relates to the technical field of medical equipment, in particular to an intelligent closed-loop vagus nerve stimulation regulation and control method and system. The method comprises the following specific steps: collecting an electroencephalogram signal and a stimulation signal during real-time stimulation, and obtaining an electroencephalogram signal prediction value of future N steps through an ambulatory electroencephalogram signal prediction model; calculating a depression biomarker estimated value for representing the brain activity state at the next moment according to the electroencephalogram signal predicted values of the next N steps; calculating an optimal stimulation signal at the next time according to a difference value between the depression biomarker target value and the depression biomarker estimated value; and updating the stimulation signal according to the optimal stimulation signal to stimulate the vagus nerve, and updating the stimulation signal. Meanwhile, the invention discloses a system for executing the method, the optimal stimulation parameter is calculated according to the difference between the predicted brain activity state at the next moment and the target state, so that the neural activity is controlled, and the adjusting efficiency and the control precision of the percutaneous vagus nerve stimulation system are improved.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate. Further, additional improvements in nerve localization and targeting may reduce the number of needle insertions, applied treatment cycles, and may also reduce the number of cartridge changes.

The invention relates to a minimally invasive implantable frontal lobe brain-computer interface method and device, and the method comprises the steps: constructing an individualized brain three-dimensional model according to CT and MRI image data of a patient, presetting an optimal nasal implantation path, and carrying out the implantation of the patient through a nose under the dual guidance of a nasal endoscope and a three-dimensional navigation system, constructing a skull base passage through minimally invasive trimming of a nasal cavity / paranasal sinus structure, and performing real-time matching and overlapping on an endoscope view and the three-dimensional model by using a rigid body transformation algorithm to display the position of a surgical instrument; windowing at a preset target point, implanting the flexible electrode array into a target brain region according to a planned depth and angle through a controllable propulsion mechanism, and establishing a neural signal acquisition or stimulation interface; intelligent mode recognition is carried out on the collected neural signals, the intention or brain state of the user is decoded, and corresponding neural stimulation or feedback signals are generated. According to the method, accurate, safe and minimally invasive clinical intervention is realized through a full-chain technical scheme of individualized planning, real-time navigation, minimally invasive implantation and biological integration, and the application value of a brain-computer interface technology is remarkably improved.

Systems and methods for generating stimulation signals for brain or nerve stimulation are disclosed. In one arrangement, a signal generation unit generates a stimulation signal and transmits the stimulation signal to a stimulation unit. The stimulation unit applies the stimulation to a biological system. The stimulation signal is defined by at least one stimulation parameter. A data receiving unit receives time series biomarker data comprising measurement samples representing one or more biomarkers indicative of a condition of the biological system that is affected by applied stimulation based on the stimulation signal. A controller controls generation of the stimulation signal based on the received biomarker data. The controller uses a model of the biological system to estimate an optimal value of the at least one stimulation parameter using the biomarker data. The model defines strengths of contribution of measurement samples to the estimate based on the times at which the measurement samples were obtained.