2 results about "Therapy related" patented technology

The invention discloses a biomarker for predicting lung toxicity related to tumor immune checkpoint blocking treatment and application of the biomarker, and belongs to the technical field of medicine. The biomarker is a TNFSF8 gene or a TNFSF8 < + > CD4 < + > T cell, and analysis finds that the TNFSF8 gene or the TNFSF8 < + > CD4 < + > T cell is in significant positive correlation with the occurrence of immune checkpoint blocking treatment related lung toxicity. The invention also verifies the feasibility of the TNFSF8 + CD4 + T cell as the biomarker in peripheral blood and alveolar lavage fluid clinical samples for treating related pulmonary toxicity at immune checkpoints. The biomarker provided by the invention provides a scientific basis for early recognition of immune checkpoints to block treatment of related lung toxicity high-risk groups, reduces treatment risks for tumor patients and brings more clinical benefits, and has important clinical significance.

The utility model discloses a portable injection device for gene therapy relates to medical instrument technical field, including the limiting sleeve, the top fixed mounting of limiting sleeve has the top cover, the bottom fixed mounting of top cover has the piston rod, the bottom fixed connection of piston rod has the rubber piston, the outside of rubber piston is equipped with the needle cylinder. The setting of portable injection device for gene therapy limiting sleeve can carry out effective protection to the piston rod and the reset spring in, and the top cover of limiting sleeve top can better with hand carry out the adhesion, to guarantee the comfort of use, the setting of telescopic positioning mechanism can make the cooperation needle cylinder telescopic in the inside of limiting sleeve, is favorable to automatic extraction to the liquid medicine when stretching out, and is favorable to reducing the length of whole when contracting, has improved portable injection device for gene therapy use convenience and storage convenience.