28 results about "Dose delivery" patented technology

The invention discloses a four-dimensional dynamic image guided dose optimization system for tumor radiotherapy, and belongs to the technical field of medical imaging and radiotherapy. The system comprises a real-time image acquisition module, a dynamic anatomical model construction module, an organ deformation prediction module, a motion compensation engine, a four-dimensional dose accumulation calculation module, a self-adaptive treatment plan generation module and a dose delivery control module. A patient-specific four-dimensional dynamic anatomical model is constructed based on a deep neural network, an autoregression algorithm is adopted to predict organ motion trails, motion compensation parameters are calculated in real time, cumulative dose distribution considering tissue deformation is accurately calculated, a treatment plan is automatically adjusted, and dose delivery with millimeter-level precision is achieved. According to the system, the target area coverage deviation is reduced by 62%, the normal tissue irradiation dose is reduced by 37%, and the precision and safety of thoracic and abdominal tumor radiotherapy are remarkably improved.

The invention relates to a delivery dose control method for adaptive radiotherapy, computer equipment, a storage medium and a program product. The method comprises the following steps: collecting a positron signal while carrying out first delivery on beam energy of an initial dose to a target position; stopping beam irradiation in a preset time period, and collecting a positron signal in the preset time period to generate a positron activity distribution image; registering the positron activity distribution image with a preset template, and calculating to obtain a deviation value; judging whether the deviation value exceeds a preset threshold value or not; when the judgment result is yes, the irradiation parameters of the beam are adjusted, and the target position is covered with the beam energy of the residual dose; wherein the residual dose is greater than the initial dose. Through staged dose delivery, a small amount of dose is delivered first, then the acquired activity distribution image is registered with the preset template, and the remaining dose delivery is adjusted in real time according to the deviation value, so that the subsequent dose can cover the target position, and the method is suitable for the radiotherapy plan in different times, and the dose delivery precision is high.

In a dose setting mode of a dose delivery device, a dose selector is rotated to turn a nut, which thereby moves backward along a thread of a piston rod through a first axial distance. A gearing mechanism transmits the axial movement of the nut to a connector that moves backward, without rotation, through a second axial distance. In a dose delivery mode of the device, the dose selector is pushed forward and drives the connector to move forward through the second axial distance. The gearing mechanism transmits the axial movement of the connector to the nut, which pushes the piston rod forward, without rotation, through the first axial distance. The gearing mechanism includes a first gear that rotates without axial movement relative to the housing, and a second gear that rotates without axial movement relative to the nut.

Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

The present invention relates to a theranostics delivery system or radiopharmaceutical delivery system (100) comprising a movable ergonomic workstation (3) having a handle on the side for moving a cart. The radiopharmaceutical delivery system (100) includes a simple design and several enhanced safety features for the user. The delivery system (100) includes a disposable secondary containment system (2) to protect the core workstation from contamination, a configurable dose transporter (6) to enable the safe transport of hot doses between the hot lab and the injection site, and a disposable sealed fluid cartridge (7) for drawing custom volumes from vials or syringes. The delivery system (100) includes a theranostics information science management system comprising a computer screen (19) as a graphical user interface (GUI) with a retractable rotating arm (20) to receive various patient injection parameters and to effectively manage the delivery of desired doses to patients.

The present disclosure relates to a dose detection system for use in combination with a medication delivery device. In one aspect, the system includes a module keyed to the device and including a sensor operable to detect the relative angular position of a sensed element attached to the medication delivery device. The system determines the type of medication contained by the device, and / or the type of device, based on the detected angular position of the sensed element. In another aspect, the dose detection system is used in combination with a medication delivery device including a dose setting member which rotates relative to an actuator during dose delivery. The dose detection system includes a sensor and is operable to detect the relative angular positions of a sensed element attached to the dose setting member during dose delivery and to determine the amount of dose delivered. Related methods are also disclosed.

An aerosol-generating device (1) comprises a heating element (8); a dose delivery assembly (2) comprising a cutting mechanism (4) disposed in a cutting region and configured to cut a portion from an aerosol-generating article (20) received by the aerosol-generating device; and a transfer mechanism (6) configured to transfer the cut portion of the aerosol-generating article from the cutting region to the heating element. The cutting mechanism can comprise a first blade (41) having a first cutting direction and a second blade (42) having a second cutting direction different from the first cutting direction.

The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery. The dose detection system comprises a module including a rotation sensor attached to the actuator during dose delivery. A sensed element is attached to the dose setting member and includes first gear teeth. The rotation sensor comprises a driven gear including second gear teeth. The second gear teeth are operatively received by the first gear teeth and are driven in rotation as the first gear teeth rotate during dose delivery. The rotation sensor is responsive to the rotation of the second gear teeth to detect the rotation of the dose setting member.

A drug delivery device that includes a body storing a VEGF antagonist, a plunger rod contacting a stopper inside the body, and a flange coupled to the body. The body is silicone-free. The plunger rod includes protrusions and the flange includes a proximal collar and slots positioned along the proximal collar. The flange is configured such that when the protrusions and slots are misaligned, distal movement of the plunger rod relative to the body is limited upon the protrusions contacting the proximal collar to prime the drug delivery device. The flange is configured such that when the protrusions and slots are aligned, distal movement of the plunger rod relative to the body is limited upon the protrusions extending into the slots to deliver the VEGF antagonist.

A histotripsy therapy system configured for tissue treatment, which may include any number of features, is provided. Systems and methods providing effective, non-invasive and minimally invasive therapeutic, diagnostic, and research procedures are provided herein. Systems and methods are provided to facilitate real-time monitoring of delivered dose and tissue dissection. Techniques may include monitoring received acoustic cavitation emission signals or using dMRI.

The present disclosure relates to a dose detection system for use in combination with a medication delivery device. In one aspect, the system includes a module keyed to the device and including a sensor operable to detect the relative angular position of a sensed element attached to the medication delivery device. The system determines the type of medication contained by the device, and / or the type of device, based on the detected angular position of the sensed element. In another aspect, the dose detection system is used in combination with a medication delivery device including a dose setting member which rotates relative to an actuator during dose delivery. The dose detection system includes a sensor and is operable to detect the relative angular positions of a sensed element attached to the dose setting member during dose delivery and to determine the amount of dose delivered. Related methods are also disclosed.

A method of delivering a dose from a single dose syringe includes applying a user input to a rotational component of a plunger rod assembly that is engaged with a plunger rod of the plunger rod assembly to advance a plunger seal in a direction parallel to an axis of rotation of the rotational component from an initial position towards a start of dose delivery position, and upon disengagement of the rotational component from the plunger rod, applying an axial user input to the plunger rod of the plunger rod assembly to advance the plunger seal from the start of dose delivery position to a completion of dose delivery position to deliver the dose, wherein the completion of dose delivery position is defined by abutment between the plunger rod and a housing of the plunger rod assembly.

The invention relates to a drug injection device comprising a cartridge housing accommodating a drug cartridge, a dose setting mechanism and a dose delivery mechanism. The dose setting mechanism comprises a dose setting service member arranged to rotate about said longitudinal axis during drug dose setting. The dose setting mechanism further comprises a final dose setting arrangement to prevent a user from setting a drug dose larger than the remaining drug amount in the cartridge after at least one previous drug dose delivery. The final dose setting arrangement comprises a pinion and a rack, the pinion being arranged coaxially with said longitudinal axis in a fixed axial position relative to the cartridge housing and arranged to rotate about the longitudinal axis together with the dose setting service member during drug dose setting, the rack being movable in a direction parallel to the longitudinal axis when the pinion is rotated. The pinion and the rack have mutually abutting members arranged to abut against each other and prevent further rotation of the pinion after the rack has been moved an axial length related to a predetermined drug amount.

The invention discloses a PDT treatment temperature sensing optical fiber probe based on a molten ball-FP cavity and a preparation method thereof, relates to the technical field of medical optical treatment, and aims to solve the problems that an existing PDT optical fiber probe is uneven in light dose delivery, lack of'temperature-power 'cooperative monitoring in the treatment process, poor in power detection adaptability and high in deep transmission loss. According to the technical scheme, a molten ball part is arranged on a coreless optical fiber; a coating layer at one end of the coreless optical fiber is removed, a cladding is subjected to fused tapering to form a tapering part, UV glue is arranged on the tapering part, and an FP cavity structure is formed between the tapering part and the UV glue; an integrated design of a coreless optical fiber matrix, a molten ball treatment section (a molten ball part), a tapering structure, FP cavity temperature sensing and in-vitro tetrahedron CCD photosensitive element power detection is adopted, light energy is enhanced through molten ball light condensation, lateral light emitting distribution is optimized through tapering, real-time temperature sensing is achieved through an FP cavity, and the temperature sensing precision is improved. Therefore, precise light dose delivery and multi-parameter cooperative monitoring of PDT treatment are realized.

An apparatus for discretizing the dosage of particles to be placed on a water-soluble substrate, comprising a hopper feeder that provides a continuous flow of particles on a belt to a discretization unit, wherein a funnel-shaped discretization unit converts the continuous flow of particles from the feeder system into individual dosages, receives the particles through an inlet, and delivers the individual dosages through a separate outlet to the substrate moving on the belt in sync with the funnel.

A drug delivery device is provided having a sensor in the form of a single pole double throw (SPDT) switch, a translation control module that receives a signal from the SPDT switch and generates an output signal, and associated power control circuitry. The SPDT switch can interact with a rotating component having a plurality of teeth that slide against an arm during dose delivery. Contact between the arm of the SPDT switch and the top of a tooth places the SPDT switch in a set state, while lack of contact between the arm and the top of a tooth places the SPDT switch in a reset state. The SPDT switch and SR logic switch can be used to sense the dose of drug delivered during dose delivery. The power control circuitry can include a sleep state that reduces battery consumption during periods of non-use, and a wake state that senses the dose being administered.

The present application relates to an optical imaging device and method. According to an embodiment, the optical imaging device can include: a treatment head, an accessory cavity formed inside; at least two imaging units arranged in the accessory cavity, used for collecting target body images; an image data analysis unit connected with the at least two imaging units, used for analyzing the target body images; wherein the optical lens of the at least two imaging units is directed to the central axis of the treatment head, and the central axis of the optical lens converges to the central axis of the treatment head. The optical imaging device and method can be applied to a radiotherapy device, through accurate positioning of the irradiated area and establishing the spatial position relationship of the irradiated area relative to the radiotherapy device, so as to realize accurate dose delivery.

A drug delivery device that includes a body storing a VEGF antagonist, a plunger rod contacting a stopper inside the body, and a flange coupled to the body. The body is silicone-free. The plunger rod includes protrusions and the flange includes a proximal collar and slots positioned along the proximal collar. The flange is configured such that when the protrusions and slots are misaligned, distal movement of the plunger rod relative to the body is limited upon the protrusions contacting the proximal collar to prime the drug delivery device. The flange is configured such that when the protrusions and slots are aligned, distal movement of the plunger rod relative to the body is limited upon the protrusions extending into the slots to deliver the VEGF antagonist.

The invention discloses a small animal proton mini-beam irradiation system and method based on a 3D printing collimator, and the system comprises a supporting mechanism which comprises a supporting pedestal and a supporting backboard extending upwards from the supporting pedestal; the positioning mechanism comprises a bearing platform and a lifting driving assembly; the collimator assembly is arranged on the bearing platform and is provided with a beam outlet surface facing the supporting base; the lifting driving assembly drives the bearing platform to do lifting motion so as to drive the beam outlet surface of the collimator assembly to actively approach or fit the surface of the target area of the small animal to be irradiated; the verification control module is configured to perform Monte Carlo dose simulation based on the individualized image data of the small animal to be irradiated in combination with the physical model of the collimator assembly to generate predicted dose distribution; and the accuracy of dose delivery is verified by comparing the actually measured dose distribution obtained by using the collimator assembly with the predicted dose distribution. And a reliable, accurate and repeatable technical means is provided for proton mini-beam research.

A device for drug delivery includes a casing for housing a drug storage container including a dose delivery member. At least a portion of the dose delivery member extends through an opening in the casing. A guard is movable relative to the casing between an extended position and a retracted position. An interference arrangement provides a selected threshold of resistance to movement of the guard from the extended position to the retracted position during insertion of the dose delivery member into body tissue at an injection site. The interference arrangement has a first member and a second member engaging one another to retain the guard in the extended position. One of the first member and the second member moving if the selected threshold of resistance is exceeded to allow the first member and second member to slide past one another to allow the guard to move into the retracted position.

This invention provides a piston motion system and operating method for a continuous micro-dose delivery device. The system includes a power-release device releasing a specified piston stroke under the action of a control device. The power-release device outputs a rotational torque to drive the piston body of the piston pusher device to move along a specified direction for the specified piston stroke. Sufficient drug solution is added to the drug storage device. The control device receives an externally input injection command or injection program. The control device initiates control of the power-release device to release the specified piston stroke, and the power-release device outputs a rotational torque to drive the piston body of the piston pusher device to move along a specified direction for the specified piston stroke. By driving the piston through the output rotational torque, the required number of pulses can be calculated based on the required infusion dose or piston movement distance. The control device precisely controls the power-release device to release the specified piston stroke, which helps improve the accuracy of drug delivery. Furthermore, the system is simple in structure and low in cost.

This disclosure relates, in general, to ophthalmic compositions and multi-dose systems for topically applying the compositions to a surface, for example, the ocular surface. The multi-dose systems of this disclosure may include a multi-dose preservative-free (MDPF) eye drop bottle system and an ophthalmic composition having a therapeutic agent, a viscosity modifier having a concentration of about 0.01% w / v to about 5% w / v, and a surfactant having a concentration of about 0.005% w / v to about 7% w / v, wherein the composition is preservative-free.

The present disclosure provides a dose delivery mechanism and a medicament delivery device having a housing holding a medicament container and a power unit. The power unit has a plunger rod, a drive spring, operably arranged to act on the plunger rod and on the medicament container. A locking ring is operatively engaged with an actuator having a holding ledge that can releasably hold the plunger rod with the drive spring in a tensioned state, and with an actuator sleeve to form a lock that prevents axially movement of the actuator after dose delivery. The locking ring also cooperates with the actuator to generate an end-of-dose delivery signal. An activator is directly engaged with the actuator to provide a well-defined activation point.

A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy / s). Multiplexed transducers detect US and iRAI signals allowing for anatomical / functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.

A drug delivery device is provided, comprising a device body and a dose setting member attached to the device body and rotatable relative to the device body about a rotation axis during dose setting or dose delivery. The drug delivery device further includes a sensor comprising a light source directed in a first direction for emitting sensing light during dose setting or dose delivery and a photosensor directed in a second direction for receiving sensing light during dose setting or dose delivery, wherein the light source is positioned relative to the photosensor such that the first direction is at an angle to the second direction. The drug delivery device further includes an electronic assembly that communicates with the photosensor to determine data indicating drug delivery information for the drug delivery device based on the reception of light sensed by the photosensor.

The present disclosure provides a fluid delivery consumable for delivering a fluid dose to a bioreactor. The fluid delivery consumable includes a vial for holding the fluid dose, a plunger, and a connector. The vial includes an outlet and an open end opposite to the outlet. The plunger is engaged with the open end and operable to urge the fluid dose toward the outlet. The connector is proximal to the outlet and attachable to the bioreactor. The connector is adapted to transfer the fluid dose from the vial to the bioreactor when the plunger is operated to urge the fluid dose out of the outlet of the vial.

This invention discloses a patient fixation device and positioning method for boron neutron capture therapy, belonging to the field of surgical medical device technology. It includes a positioning plate, a head positioning plate, and a connector between the positioning plate and the head positioning plate. The two edges of the positioning plate taper inward at corresponding shoulder positions to form a shoulder avoidance structure. The patient fixation device also includes a posture monitoring unit and an adjustment data display unit. The posture monitoring unit is used to monitor the spatial position of the head positioning plate in real time. This invention forms a closed-loop control mechanism through the posture monitoring unit and the adjustment data display unit, monitoring the spatial pose of the head positioning plate in real time during treatment and automatically performing dynamic compensation when minute displacements occur, ensuring that the patient's target area is always accurately maintained in the preset treatment position. High-precision pose maintenance improves the accuracy of dose delivery, thereby comprehensively improving the treatment efficiency and clinical efficacy of boron neutron capture therapy.