69 results about "Dose delivery" patented technology

The invention relates to the field of navigation signal processing, and discloses a radiation therapy bolus dose feedback and tracking system based on image registration, the system comprises an image acquisition module, an image registration module, a bolus identification module, a dose recalculation module, a dose deviation analysis module and a feedback and adjustment module, space registration is carried out through an FBCT image acquired every day and an original plan CT, and the radiation therapy bolus dose feedback and tracking system based on image registration is obtained. The fitting state between the bolus and the skin is automatically identified, the position of an air gap is detected, and dose recalculation is carried out based on an actual structure. Through comparison with an original planned dose, the system can output a deviation index of a key dose parameter and provide visual feedback, if the deviation exceeds a set threshold value, a prompt is automatically sent out, and a radiotherapy technician and a physician are supported to carry out bolus adjustment or call an adaptive planning engine to reconstruct a treatment plan. Quantitative analysis of bolus fitting quality and closed-loop control of dose delivery consistency are realized, radiotherapy precision and safety are effectively improved, and the method is suitable for superficial radiotherapy scenes containing bolus design.

Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field (PEF) energy to target tissue areas in a specific dose so as to obtain a superior outcome. The PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. These various types of treatment are controlled by a variety of factors including the electrode geometry, the dose of PEF energy delivered, the time the energy is delivered over, and the waveform of the PEF energy itself. The PEF energy is delivered in the form a dose which is considered to be one application of the specialized energy. Each dose creates a lesion in the target tissue area.

Disclosed herein are systems and methods for adapting and / or updating radiotherapy treatment plans based on biological and / or physiological data and / or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and / or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.

The present invention relates to a multi-mode fluid delivery device for drugs and vaccines for use in the fields of human clinical care and animal health care. Through the design that multiple needles and multiple holes are matched with the detachable injection head and the needle head piece contained in the detachable injection head, all the advantages of a needle-free injection mode, a micro-needle injection mode and a needle injection mode are combined, the defects of the needle-free injection mode, the micro-needle injection mode and the needle injection mode are eliminated, flexible switching among the needle-free mode, the micro-needle injection mode and the needle injection mode is achieved, and the injection efficiency is improved. The single delivery amount and delivery efficiency of drugs and vaccines are improved while painless and skin injury are avoided, liquid leakage is eliminated, the drugs and vaccines are delivered to one or more target positions with different depths of a human body, the three-dimensional dispersity of the drugs and vaccines at the target positions is controlled, pharmacokinetics is optimized, and the drug delivery efficiency of the drugs and vaccines is improved. Therefore, the contact effect and the bioavailability of the medicine and the vaccine with in-vivo tissues are greatly improved. Related components, systems, and related pharmaceutical and mechanical combinations are also provided.

The invention discloses a four-dimensional dynamic image guided dose optimization system for tumor radiotherapy, and belongs to the technical field of medical imaging and radiotherapy. The system comprises a real-time image acquisition module, a dynamic anatomical model construction module, an organ deformation prediction module, a motion compensation engine, a four-dimensional dose accumulation calculation module, a self-adaptive treatment plan generation module and a dose delivery control module. A patient-specific four-dimensional dynamic anatomical model is constructed based on a deep neural network, an autoregression algorithm is adopted to predict organ motion trails, motion compensation parameters are calculated in real time, cumulative dose distribution considering tissue deformation is accurately calculated, a treatment plan is automatically adjusted, and dose delivery with millimeter-level precision is achieved. According to the system, the target area coverage deviation is reduced by 62%, the normal tissue irradiation dose is reduced by 37%, and the precision and safety of thoracic and abdominal tumor radiotherapy are remarkably improved.

The present embodiments relate generally to enabling an end user - e.g. medical physicists - to monitor radiation therapy and, with integration to the LINAC, adaptive radiotherapy. Embodiments record signals already released during radiotherapy, requiring no new irradiation of the patient for in vivo, in line, dose monitoring. Furthermore, as the transducers will be coupled to the patient with ultrasound gel, the present embodiments are not invasive to patients and will not introduce new discomfort during therapeutic procedures. The addition of the RiAD system provides the end user with additional information during the treatment of the patient, allowing for real-time beam tracking and dosimetry, enabling the end user to practice adaptive radiotherapy. The RiAD system enables the end user to ensure that proper dose delivery is occurring with each new beamlet and dose deposition, empowering them to adapt the medical treatment as it is performed and increase its precision in conventional electron beam radiotherapy, electron FLASH radiotherapy, and intraoperative electron beam radiotherapy.

An institutional unit for a drug delivery device, the institutional unit comprising a housing (10), a piston rod (30), and a dose setting and driving mechanism configured to perform a dose setting operation and a dose delivery operation by transmitting a delivery force to the piston rod (30) so as to drive the piston rod (30) in a distal direction during the dose delivery operation, wherein the dose setting and driving mechanism includes a first driving member (40a), a second driving member (40b), and an adapter mechanism having at least two different states: a setting state and a delivery state, wherein, in the setting state, the second driving member (40b) is rotationally fastened relative to the housing (10) at least against rotation in the delivery direction, and wherein, in the delivery state, the second driving member (40b) is rotatable relative to the housing (10) in the delivery direction, wherein, in the setting state, the first driving member (40a) is rotatable relative to the second driving member (40b) at least in the delivery direction, and wherein, in the delivery state, the second driving member (40b) is rotationally locked to the first driving member (40a) at least against rotation of the second driving member (40b) relative to the first driving member (40a) in the delivery direction.

The invention relates to a delivery dose control method for adaptive radiotherapy, computer equipment, a storage medium and a program product. The method comprises the following steps: collecting a positron signal while carrying out first delivery on beam energy of an initial dose to a target position; stopping beam irradiation in a preset time period, and collecting a positron signal in the preset time period to generate a positron activity distribution image; registering the positron activity distribution image with a preset template, and calculating to obtain a deviation value; judging whether the deviation value exceeds a preset threshold value or not; when the judgment result is yes, the irradiation parameters of the beam are adjusted, and the target position is covered with the beam energy of the residual dose; wherein the residual dose is greater than the initial dose. Through staged dose delivery, a small amount of dose is delivered first, then the acquired activity distribution image is registered with the preset template, and the remaining dose delivery is adjusted in real time according to the deviation value, so that the subsequent dose can cover the target position, and the method is suitable for the radiotherapy plan in different times, and the dose delivery precision is high.

In a dose setting mode of a dose delivery device, a dose selector is rotated to turn a nut, which thereby moves backward along a thread of a piston rod through a first axial distance. A gearing mechanism transmits the axial movement of the nut to a connector that moves backward, without rotation, through a second axial distance. In a dose delivery mode of the device, the dose selector is pushed forward and drives the connector to move forward through the second axial distance. The gearing mechanism transmits the axial movement of the connector to the nut, which pushes the piston rod forward, without rotation, through the first axial distance. The gearing mechanism includes a first gear that rotates without axial movement relative to the housing, and a second gear that rotates without axial movement relative to the nut.

The present specification contemplates apparatuses, methods and systems including a volumetric additive manufacturing (VAM) printer with a high angular dose delivery rate including projections optimized for low-viscosity printing conditions. High-fidelity VAM printing in poly(ethylene glycol) diacrylate PEGDA with viscosities as low as 12 cP is disclosed.

Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

The present invention relates to a theranostics delivery system or radiopharmaceutical delivery system (100) comprising a movable ergonomic workstation (3) having a handle on the side for moving a cart. The radiopharmaceutical delivery system (100) includes a simple design and several enhanced safety features for the user. The delivery system (100) includes a disposable secondary containment system (2) to protect the core workstation from contamination, a configurable dose transporter (6) to enable the safe transport of hot doses between the hot lab and the injection site, and a disposable sealed fluid cartridge (7) for drawing custom volumes from vials or syringes. The delivery system (100) includes a theranostics information science management system comprising a computer screen (19) as a graphical user interface (GUI) with a retractable rotating arm (20) to receive various patient injection parameters and to effectively manage the delivery of desired doses to patients.

This invention provides a continuous micro-dose delivery device and injection method, including a needle device, a drug storage device, a piston pusher device, a power storage device, a power release device, and a control device. Under the action of the control device, the power release device releases a specified piston stroke, and the power storage device pushes the piston pusher device to move a specified piston stroke into the drug storage device, through which the drug solution in the drug storage device is discharged via the needle device. Using the power storage device as a power source, the piston is driven by rotation or direct push. The required number of pulses is calculated based on the dosage to be infused or the distance the piston travels, and the control device precisely controls the power release device to release the specified piston stroke, thus improving the accuracy of the drug delivery dosage. A coupling assembly consisting of multiple gears connects the rotary magnetic brake assembly and the piston pusher device, enabling the rotary magnetic brake assembly to control a larger force from the power storage device with a smaller force.

A dose delivery mechanism includes a housing, a piston rod, and an adjusting element. The housing connecting to a container sealed by a plunger. In an assembled state, the dose delivery mechanism moves the piston rod axially in a proximal direction during dose delivery such that the piston rod exerts an axial force on the plunger to expel a medicament. In the preassembled state, the adjusting element rotates with respect to the housing, causing axial movement of the piston rod to adjust an axial position of the piston rod prior to transfer of the dose delivery mechanism from the preassembled state into the assembled state. An outer rim of the adjusting element effects rotation of the adjusting element and axial movement of the piston rod. The adjusting element performs rotation at least while being in a preassembled position with respect to the housing.

Methods and systems for providing stimulation therapy are disclosed. Embodiments of the system include an implantable stimulator and an external controller configured to control the implantable stimulator. A clinician can prescribe a set amount of stimulation therapy to a patient. The external controller is programmed with the prescription. As the patient uses the external controller and the stimulator device the external controller tracks the amount of stimulation the patient uses. Once the patient has used all of the prescribed therapy the patient may return to the clinician for a follow-up appointment.

[Medicament delivery device] The present disclosure relates to a medicament delivery device (1) extending generally along a longitudinal axis (L), and having a proximal end configured to point towards a dose delivery site and a distal end configured to point away from the dose delivery site, the medicament delivery device (1) comprising: - a cassette (10) comprising a syringe holder (13) for holding a syringe (14) - a power pack (20) comprising  a drive spring (25)  a plunger rod (24) to expel medicament from the syringe (24) when driven proximally by the drive spring (25) - a distal button (22) wherein the syringe holder (13) comprises a least a leg (133) extending distally and having, at its distal end, a seat (133a) for a proximal part (242a) of a lever (242) of the plunger rod (24) such that when the proximal part (242a) is received in the seat (133a), the plunger rod (24) cannot move proximally relative to the syringe holder (13), wherein the button (22) comprises at least an arm (222) extending proximally and having, at its proximal end, a knob (222a) configured such that a proximal movement of the button (22) brings the knob (222a) into contact with a bottom surface (242b) of the lever (242), thereby lifting the proximal part (242a) of the lever (242) out of the seat (133a).

A dose delivery mechanism includes a piston rod and a nut, the piston rod forms an outer thread meshing with an inner thread of the nut. During dose setting, the nut rotates relative to the piston rod to advance the nut with respect to the piston rod by a first distance into a distal direction, an actuation member that is movable by a user to effect delivery of a set dose, and a housing. A second threaded connection causes the actuation member to travel a second distance into the distal direction during dose setting. The the actuation member is coupled via the nut to the piston rod during dose delivery to advance the piston rod by the first distance into a proximal direction upon proximal movement of the actuation member by the second distance, and the second distance is less than 1.5 times the first distance.

A set includes a medicament delivery device with a dose delivery activation mechanism to adjust the medicament delivery device from an inactive state to an active state in which a dose is deliverable, and a cover. The cover is mechanically attached to the medicament delivery device prior to use of the medicament delivery device. The cover covers a part of the dose delivery activation mechanism so that a user is restrained from prematurely activating the medicament delivery device, and the cover is movable in a distal direction to uncover the part of the dose delivery activation mechanism to activate the medicament delivery device during use of the medicament delivery device.

The present disclosure relates to a dose detection system for use in combination with a medication delivery device. In one aspect, the system includes a module keyed to the device and including a sensor operable to detect the relative angular position of a sensed element attached to the medication delivery device. The system determines the type of medication contained by the device, and / or the type of device, based on the detected angular position of the sensed element. In another aspect, the dose detection system is used in combination with a medication delivery device including a dose setting member which rotates relative to an actuator during dose delivery. The dose detection system includes a sensor and is operable to detect the relative angular positions of a sensed element attached to the dose setting member during dose delivery and to determine the amount of dose delivered. Related methods are also disclosed.

An aerosol-generating device (1) comprises a heating element (8); a dose delivery assembly (2) comprising a cutting mechanism (4) disposed in a cutting region and configured to cut a portion from an aerosol-generating article (20) received by the aerosol-generating device; and a transfer mechanism (6) configured to transfer the cut portion of the aerosol-generating article from the cutting region to the heating element. The cutting mechanism can comprise a first blade (41) having a first cutting direction and a second blade (42) having a second cutting direction different from the first cutting direction.

An electronic system for a drug delivery device comprising a dose setting and drive mechanism with a first member, wherein the first member performs a specific movement relative to a second member during a dose delivery operation. The electronic system comprises a first switch configured to be activated by a pre-defined user operation, wherein the pre-defined user operation includes a user operation that is expected in conjunction with dose delivery operation, a second switch for indicating the specific movement, and a sensor arrangement for a motion sensor system for providing position data that allows to distinguish between different positions of the first member relative to the second member.

The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery. The dose detection system comprises a module including a rotation sensor attached to the actuator during dose delivery. A sensed element is attached to the dose setting member and includes first gear teeth. The rotation sensor comprises a driven gear including second gear teeth. The second gear teeth are operatively received by the first gear teeth and are driven in rotation as the first gear teeth rotate during dose delivery. The rotation sensor is responsive to the rotation of the second gear teeth to detect the rotation of the dose setting member.

The present invention relates to a signalling module (100) for a medicament delivery device (10), the medicament delivery device comprising a power pack (42), in turn comprising a drive spring (44) operably connected to a plunger rod (46), the plunger rod arranged to, when the power pack is activated, act on a syringe (36) for delivering a dose of medicament, the signalling module (100) comprising: a signalling element (102; 110) comprising at least one biased force element (106; 114) operably connected to said plunger rod; an impact surface (44; 56); the signalling element (102; 110) being held in a tensioned state by the plunger rod (46) in an initial state, wherein, when the power pack (42) is activated, causes a linear movement of the plunger rod (46) in a proximal direction, thereby releasing the signalling element (102; 110) at a position close to end of dose delivery, wherein said signalling element hits said impact surface (44; 56) and causes an indication to a user that a dose of medicament has been delivered.

The present invention relates to a therapeutic diagnostic delivery system or radiopharmaceutical delivery system (100) with a movable ergonomic workstation (3) having on the side (s) a handle to move a cart. The radiopharmaceutical delivery system (100) includes a simple design and a plurality of enhanced safety features for a user. The delivery system (100) comprises a jettable secondary containment system (2) that protects the core workstation from contamination, a configurable dose conveyor (6) that allows safe delivery of strong radiation doses between a strong radiation laboratory to an infusion site, and a jettable sealed fluid cartridge (7) to draw customized volumes from vials or syringes. The delivery system (100) includes a therapeutic diagnostic information management system having a computer screen (19) as a graphical user interface (GUI), the computer screen having a retractable rotating arm (20), in order to receive various patient infusion parameters and effectively manage delivery of a desired dose to a patient.

A method for treating a prostate comprising the steps of using a needle-syringe coupled to a dose delivery device. The dose delivery device comprises a housing, a holder configured to receive a first portion of the needle-syringe, and an arm at least partially extending from the housing. The arm includes a surface configured to engage a second portion of the needle-syringe. The dose delivery device further includes an actuation member movable with respect to the housing, a worm coupled to the actuation member, a worm gear engaged with the worm, and a pinion gear fixed to the worm gear and engaged with the arm. The arm moves along a translation axis in response to user actuation of the actuation member about a rotational axis.

A drug delivery device that includes a body storing a VEGF antagonist, a plunger rod contacting a stopper inside the body, and a flange coupled to the body. The body is silicone-free. The plunger rod includes protrusions and the flange includes a proximal collar and slots positioned along the proximal collar. The flange is configured such that when the protrusions and slots are misaligned, distal movement of the plunger rod relative to the body is limited upon the protrusions contacting the proximal collar to prime the drug delivery device. The flange is configured such that when the protrusions and slots are aligned, distal movement of the plunger rod relative to the body is limited upon the protrusions extending into the slots to deliver the VEGF antagonist.

Medication delivery devices are provided having a dose delivery sensing capability. A dose button includes a support and a cover that at least partially encloses an electronics assembly including a sensor for detecting rotation of a component during dose delivery to determine a dosage of delivered medication. The electronics assembly includes a controller for receiving a signal from the sensor. The medication delivery device may be configured to communicate dosage delivery information to an external device.

The invention provides a radiotherapy dose real-time monitoring system, which comprises a data interface module for acquiring multi-source data related to radiotherapy in real time, the multi-source data comprises plan data imported from a treatment plan system, and the plan data comprises three-dimensional plan dose distribution and plan anatomical structure data; according to the invention, the real-time dynamic monitoring of the radiation treatment dose is realized, the limitation that only pre-verification before treatment or offline analysis after treatment can be carried out in the traditional technology is broken through, the treatment plan data, the machine operation parameters and the real-time anatomical image of the patient are integrated, and the real-time monitoring of the radiation treatment dose is realized. A multi-source data fusion processing mechanism is innovatively constructed, the comprehensive influence of machine execution deviation and anatomical change of a patient on the dose is quantified in real time, actual dose distribution in a body is dynamically reconstructed, dose delivery is changed from an invisible black box state to a real-time traceable visual process, and accurate monitoring of the radiotherapy dose in treatment is truly realized.

A histotripsy therapy system configured for tissue treatment, which may include any number of features, is provided. Systems and methods providing effective, non-invasive and minimally invasive therapeutic, diagnostic, and research procedures are provided herein. Systems and methods are provided to facilitate real-time monitoring of delivered dose and tissue dissection. Techniques may include monitoring received acoustic cavitation emission signals or using dMRI.

The present disclosure relates to a dose detection system for use in combination with a medication delivery device. In one aspect, the system includes a module keyed to the device and including a sensor operable to detect the relative angular position of a sensed element attached to the medication delivery device. The system determines the type of medication contained by the device, and / or the type of device, based on the detected angular position of the sensed element. In another aspect, the dose detection system is used in combination with a medication delivery device including a dose setting member which rotates relative to an actuator during dose delivery. The dose detection system includes a sensor and is operable to detect the relative angular positions of a sensed element attached to the dose setting member during dose delivery and to determine the amount of dose delivered. Related methods are also disclosed.