169 results about "Dose delivery" patented technology

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

The invention relates to the field of navigation signal processing, and discloses a radiation therapy bolus dose feedback and tracking system based on image registration, the system comprises an image acquisition module, an image registration module, a bolus identification module, a dose recalculation module, a dose deviation analysis module and a feedback and adjustment module, space registration is carried out through an FBCT image acquired every day and an original plan CT, and the radiation therapy bolus dose feedback and tracking system based on image registration is obtained. The fitting state between the bolus and the skin is automatically identified, the position of an air gap is detected, and dose recalculation is carried out based on an actual structure. Through comparison with an original planned dose, the system can output a deviation index of a key dose parameter and provide visual feedback, if the deviation exceeds a set threshold value, a prompt is automatically sent out, and a radiotherapy technician and a physician are supported to carry out bolus adjustment or call an adaptive planning engine to reconstruct a treatment plan. Quantitative analysis of bolus fitting quality and closed-loop control of dose delivery consistency are realized, radiotherapy precision and safety are effectively improved, and the method is suitable for superficial radiotherapy scenes containing bolus design.

Disclosed herein are systems and methods for adapting and / or updating radiotherapy treatment plans based on biological and / or physiological data and / or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and / or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.

A drug delivery device for setting and dispensing doses of a liquid drug is described. The device includes a housing and a dose setting and drive mechanism with a dose setting member and a dose setting drum. The dose setting and drive mechanism is configured to perform a dose setting operation for setting a dose to be delivered by the drug delivery device by rotating the dose setting member relative to the housing and a dose delivery operation for delivering the set dose during rotation of the dose setting drum relative to dose setting member the housing. The dose setting drum includes an array of encoder features at its proximal end. The dose setting member has at least one aperture located in a proximal end surface that is coincident with at least a portion of the array of encoder features of the dose setting drum.

Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field (PEF) energy to target tissue areas in a specific dose so as to obtain a superior outcome. The PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. These various types of treatment are controlled by a variety of factors including the electrode geometry, the dose of PEF energy delivered, the time the energy is delivered over, and the waveform of the PEF energy itself. The PEF energy is delivered in the form a dose which is considered to be one application of the specialized energy. Each dose creates a lesion in the target tissue area.

The invention provides a composite collimator and a control method thereof, a radiotherapy system and a dose delivery method thereof, and relates to the technical field of radiotherapy, and the composite collimator comprises a grating and a diaphragm which are sequentially arranged in the direction of a beam center axis, the plurality of blades move to form a grating channel through which a radiation beam can pass; the diaphragm is provided with a collimation channel, and the diaphragm can move relative to a beam center axis; when the diaphragm moves to enable the collimation channel to be located at the central axis of the beam, the radiation beam forms a focusing radiation field in a target area through the grating channel and the collimation channel; and when the diaphragm moves to enable the collimation channel to deviate from the beam center axis, the radiation beam forms a conformal radiation field in the target area through the grating channel. Through switching between the conformal radiation field and the focusing radiation field, a flexible irradiation scheme is provided, so that the dose distribution effect can be improved, and the radiotherapy effect is improved.

Disclosed herein are systems and methods for adapting and / or updating radiotherapy treatment plans based on biological and / or physiological data and / or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and / or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.

A medicament delivery device for a mixing process to create a therapeutic substance for delivery within a multi-chambered cartridge, the delivery device includes a distal part with a dose setting mechanism having a housing, a dose setting knob, an injection button, a piston rod capable of moving axially along the longitudinal axis of the housing during dose delivery, and a return ring configured to reset the piston rod to a starting position. The delivery device also includes a proximal part including a cartridge holder configured to accept a multi-chambered cartridge, the cartridge holder including a screw driven sleeve configured for attachment to the distal part and rotation of the screw driven sleeve performing a medicament mixing process within the multi-chambered cartridge.

A rotatable dose selector clutch for a dose delivery device is disclosed. The dose delivery device having a dosage scale drum with interior dosage scale coupling means and a thrust bearing with exterior thrust bearing coupling means, the thrust bearing is configured to be threaded coupled to a piston rod, wherein the dose selector clutch is configured to be arranged in: •a coupled position, wherein the dose selector clutch couples to the dosage scale drum and the thrust bearing, such that the dosage scale drum and the thrust bearing rotates when the dose selector clutch is rotated, and •a decoupled position, wherein the dose selector clutch decouples from the dosage scale drum and the thrust bearing, such that the dosage scale drum and the thrust bearing are free to rotate independently of the dose selector clutch.

The invention discloses a chemical cleaning decontaminant concentration testing device and a using method, and relates to the technical field of chemical analysis, and the chemical cleaning decontaminant concentration testing device comprises a conveying unit and a control unit, the conveying unit comprises a cleaning fluid water tank and a conveying assembly arranged on the cleaning fluid water tank; the fusion reaction unit comprises a fusion assembly arranged on the conveying assembly, a heating assembly arranged in the fusion assembly and a waste liquid pump arranged at one end of the fusion assembly; the chemical cleaning decontaminant concentration testing device realizes high efficiency, high accuracy and operation convenience of a testing process through automatic control, accurate dosage conveying, efficient mixing reaction, high-sensitivity monitoring, impurity removal, remote operation, data management and waste liquid treatment, and ensures environmental safety and real-time analysis of data at the same time; the method is suitable for various industrial environments and has remarkable application advantages and market potential.

The present invention relates to a multi-mode fluid delivery device for drugs and vaccines for use in the fields of human clinical care and animal health care. Through the design that multiple needles and multiple holes are matched with the detachable injection head and the needle head piece contained in the detachable injection head, all the advantages of a needle-free injection mode, a micro-needle injection mode and a needle injection mode are combined, the defects of the needle-free injection mode, the micro-needle injection mode and the needle injection mode are eliminated, flexible switching among the needle-free mode, the micro-needle injection mode and the needle injection mode is achieved, and the injection efficiency is improved. The single delivery amount and delivery efficiency of drugs and vaccines are improved while painless and skin injury are avoided, liquid leakage is eliminated, the drugs and vaccines are delivered to one or more target positions with different depths of a human body, the three-dimensional dispersity of the drugs and vaccines at the target positions is controlled, pharmacokinetics is optimized, and the drug delivery efficiency of the drugs and vaccines is improved. Therefore, the contact effect and the bioavailability of the medicine and the vaccine with in-vivo tissues are greatly improved. Related components, systems, and related pharmaceutical and mechanical combinations are also provided.

A metal artifact reduction (MAR) method and system for reducing metal artifacts from X-ray images. The method is suitable for CT images generated with metallic elements exterior to a patient being scanned, for example, where external probes are applied to a patient, such as ultrasound probes. The method may be embodied in a computer algorithm for use, for example, in radiotherapy treatment planning and patient positioning procedures. In one application, the disclosed technique improves the dose delivery accuracy in ultrasound-guided cardiac radioablation, making this treatment modality a viable option for cardiac arrhythmias.

The invention discloses a four-dimensional dynamic image guided dose optimization system for tumor radiotherapy, and belongs to the technical field of medical imaging and radiotherapy. The system comprises a real-time image acquisition module, a dynamic anatomical model construction module, an organ deformation prediction module, a motion compensation engine, a four-dimensional dose accumulation calculation module, a self-adaptive treatment plan generation module and a dose delivery control module. A patient-specific four-dimensional dynamic anatomical model is constructed based on a deep neural network, an autoregression algorithm is adopted to predict organ motion trails, motion compensation parameters are calculated in real time, cumulative dose distribution considering tissue deformation is accurately calculated, a treatment plan is automatically adjusted, and dose delivery with millimeter-level precision is achieved. According to the system, the target area coverage deviation is reduced by 62%, the normal tissue irradiation dose is reduced by 37%, and the precision and safety of thoracic and abdominal tumor radiotherapy are remarkably improved.

The present embodiments relate generally to enabling an end user - e.g. medical physicists - to monitor radiation therapy and, with integration to the LINAC, adaptive radiotherapy. Embodiments record signals already released during radiotherapy, requiring no new irradiation of the patient for in vivo, in line, dose monitoring. Furthermore, as the transducers will be coupled to the patient with ultrasound gel, the present embodiments are not invasive to patients and will not introduce new discomfort during therapeutic procedures. The addition of the RiAD system provides the end user with additional information during the treatment of the patient, allowing for real-time beam tracking and dosimetry, enabling the end user to practice adaptive radiotherapy. The RiAD system enables the end user to ensure that proper dose delivery is occurring with each new beamlet and dose deposition, empowering them to adapt the medical treatment as it is performed and increase its precision in conventional electron beam radiotherapy, electron FLASH radiotherapy, and intraoperative electron beam radiotherapy.

A sensor device removably attachable to a drug delivery device, the sensor device comprising: a sensing arrangement arranged within the sensor device; and circuitry configured to process signals provided by the sensor arrangement, wherein the sensing arrangement is configured such that, when the sensor device is attached to the drug delivery device, the sensing arrangement is operable to sense the presence or absence of at least a part of a drive mechanism of the drug delivery device, wherein the circuitry is configured: to determine, based on sensing of the part of the drive mechanism, information relating to whether the drug delivery device is in a dose setting mode or whether the device is in a dose delivery mode.

A dose recording device for a drug delivery device, wherein the drug delivery device comprises a housing, a cartridge holder configured to receive a cartridge for holding a plurality of doses of a drug, and a dose setting member connected to the housing and configured to set the dose of the drug, is disclosed. The dose recording device comprises a device housing and a measurement system having an optical sensor connected to a portion of the device housing. The device housing is configured to be mounted to the dose setting member. The measurement system is configured to detect a relative movement of the device housing to the housing by means of the optical sensor and to store relative movement data so as to provide information on a delivery of the dose of the drug.

A dose delivery mechanism is disclosed, comprising: a housing; a piston rod configured to act on a plunger sealing the fluid compartment and move in an axial direction relative to the housing to deliver a set dose; and a dose setting member movable relative to the housing during dose setting, where a position of the dose setting member relative to the housing defines a set dose, and where, in a delivery state, the dose setting member is preset to a position corresponding to the set dose greater than zero.

A plunger rod insertion gauge for a precise dose delivery device is disclosed. The insertion gauge comprises an insertion gauge body which comprises a handle part and a gauge part; wherein the gauge portion comprises one or more plunger rod abutment surfaces and one or more flange abutment surfaces oriented substantially perpendicular to the plunger rod insertion axis; and wherein a dimension measured between the one or more plunger rod abutment surfaces and the one or more flange abutment surfaces is defined as a maximum plunger rod insertion depth of the precise dose delivery device. Other aspects are described and claimed.

A plunger rod insertion gauge for a precision dose delivery device is disclosed. The insertion gauge includes an insertion gauge body including a handle portion and a gauge portion, the gauge portion including one or more plunger rod abutment surfaces and one or more flange abutment surfaces oriented substantially perpendicular to a plunger rod insertion axis, and a dimension measured between the one or more plunger rod abutment surfaces and the one or more flange abutment surfaces determines a maximum plunger rod insertion depth for a precision dose delivery device. Other aspects are described and claimed.

The present disclosure refers to a drug delivery device for setting and dispensing doses of a liquid drug which may be used together with a module for detecting the amount of a dose selected and / or delivered. The device comprises a housing and a dose setting and drive mechanism with a dose setting member. The dose setting and drive mechanism is configured to perform a dose setting operation for selecting a dose to be delivered by rotating the dose setting member relative to the housing and a dose delivery operation for delivering the set dose by pushing the dose setting member axially towards the housing without relative rotation therebetween. The dose setting member comprises a set of axially directed stop teeth formed at its distal end which are configured to engage with a set of counterstop teeth located on the housing at the end of the dose delivery operation.

An institutional unit for a drug delivery device, the institutional unit comprising a housing (10), a piston rod (30), and a dose setting and driving mechanism configured to perform a dose setting operation and a dose delivery operation by transmitting a delivery force to the piston rod (30) so as to drive the piston rod (30) in a distal direction during the dose delivery operation, wherein the dose setting and driving mechanism includes a first driving member (40a), a second driving member (40b), and an adapter mechanism having at least two different states: a setting state and a delivery state, wherein, in the setting state, the second driving member (40b) is rotationally fastened relative to the housing (10) at least against rotation in the delivery direction, and wherein, in the delivery state, the second driving member (40b) is rotatable relative to the housing (10) in the delivery direction, wherein, in the setting state, the first driving member (40a) is rotatable relative to the second driving member (40b) at least in the delivery direction, and wherein, in the delivery state, the second driving member (40b) is rotationally locked to the first driving member (40a) at least against rotation of the second driving member (40b) relative to the first driving member (40a) in the delivery direction.

The invention relates to a delivery dose control method for adaptive radiotherapy, computer equipment, a storage medium and a program product. The method comprises the following steps: collecting a positron signal while carrying out first delivery on beam energy of an initial dose to a target position; stopping beam irradiation in a preset time period, and collecting a positron signal in the preset time period to generate a positron activity distribution image; registering the positron activity distribution image with a preset template, and calculating to obtain a deviation value; judging whether the deviation value exceeds a preset threshold value or not; when the judgment result is yes, the irradiation parameters of the beam are adjusted, and the target position is covered with the beam energy of the residual dose; wherein the residual dose is greater than the initial dose. Through staged dose delivery, a small amount of dose is delivered first, then the acquired activity distribution image is registered with the preset template, and the remaining dose delivery is adjusted in real time according to the deviation value, so that the subsequent dose can cover the target position, and the method is suitable for the radiotherapy plan in different times, and the dose delivery precision is high.

In a dose setting mode of a dose delivery device, a dose selector is rotated to turn a nut, which thereby moves backward along a thread of a piston rod through a first axial distance. A gearing mechanism transmits the axial movement of the nut to a connector that moves backward, without rotation, through a second axial distance. In a dose delivery mode of the device, the dose selector is pushed forward and drives the connector to move forward through the second axial distance. The gearing mechanism transmits the axial movement of the connector to the nut, which pushes the piston rod forward, without rotation, through the first axial distance. The gearing mechanism includes a first gear that rotates without axial movement relative to the housing, and a second gear that rotates without axial movement relative to the nut.

The present specification contemplates apparatuses, methods and systems including a volumetric additive manufacturing (VAM) printer with a high angular dose delivery rate including projections optimized for low-viscosity printing conditions. High-fidelity VAM printing in poly(ethylene glycol) diacrylate PEGDA with viscosities as low as 12 cP is disclosed.

A method and system for performing online adapted radiotherapy are provided using combined ultrasound and ionizing radiation induced acoustic imaging (iRAI) computed tomography imaging techniques that can be used for measurement of low to ultrahigh dose deliveries (>40 Gy / s). Multiplexed transducers detect US and iRAI signals allowing for anatomical / functional imaging and radiation mapping with absolute dosimetry measurements of a region of interest during a radiotherapy session. Corrections to radiation dosage intensities and locations is determined and provided as feedback to a radiation source to improve the accuracy of applied radiation dosages intra- or inter-radiotherapy treatment sessions preventing the irradiation of healthy tissues and ensuring the accurate delivery of radiation to a tumor or region of interest.

The present disclosure generally relates to ophthalmic compositions and multidose systems for topically applying compositions to a surface, e.g. an eye surface. Multidose systems of the present disclosure can include a multidose preservative-free (MDPF) eye dropper bottle system and an ophthalmic composition having an therapeutic agent, a viscosifying agent having a concentration of about 0.01% w / v to about 5% w / v, and a surfactant having a concentration of about 0.005% w / v to about 7% w / , wherein the composition lacks a preservative.

A dose delivery mechanism includes a piston rod and a nut, where the piston rod forms an external thread that meshes with an internal thread of the nut, where, during dose setting, the nut is configured to rotate relative to the piston rod to advance the nut in a distal direction relative to the piston rod by a first distance; an actuation member movable by a user to effect delivery of a set dose; and a housing wherein a second threaded connection is provided wherein the second threaded connection is configured to cause the actuation member to travel a second distance in a distal direction during dose setting wherein the actuation member is coupled to the piston rod via a nut during dose delivery, the piston rod is coupled to the actuating member to advance the piston rod in a proximal direction by a first distance when the actuating member is moved proximally by a second distance, where the second distance is less than 1.5 times the first distance.

Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

The present invention relates to a drug delivery device (1) for setting and dispensing doses of a liquid drug. The device comprises a housing (10) and a dose setting and driving mechanism having a dose setting member (70). The dose setting and driving mechanism is at least partially arranged in the housing (10). The dose setting member (70) is movable relative to the housing (10) and is configured to perform a dose setting operation for selecting a dose to be delivered by the drug delivery device by moving the dose setting member (70) relative to the housing (10), and to perform a dose delivery operation for delivering a set dose by axially displacing the dose setting member (70) along the axis (X). A maximum radial extension of the dose setting member (70) perpendicular to the axis (X) is smaller than a maximum radial extension of a region of the housing (10) adjacent to the dose setting member (70).

The present invention relates to a drug delivery device (1) for setting and dispensing a dose of a liquid drug. The device comprises a housing (10) and a dose setting and driving mechanism having a dose setting member (70). The dose setting and driving mechanism is at least partially arranged within the housing (10) and configured to perform a dose setting operation for selecting a dose to be delivered by the drug delivery device by moving the dose setting member (70) along the housing (10) and a dose delivery operation for delivering the set dose by axially displacing the dose setting member (70) along an axis (X). The maximum radial extension perpendicular to the axis (X) of the dose setting member (70) is smaller than the maximum radial extension of a region of the housing (10) located adjacent to the dose setting member (70).