209 results about "Dose delivery" patented technology

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising a pharmaceutically active amphetamine salt covered with an immediate-release coating and a pharmaceutically active amphetamine salt covered with an enteric coating wherein the immediate release coating and the enteric coating provide for multiple pulsed dose delivery of the pharmaceutically active amphetamine salt. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.

A system for capture of dose delivery information is provided. The system includes a medication delivery device, a dose information capture device adapted to be attached to the medication delivery device, and a target element adapted to be attached to the medication delivery device. The target element comprises a magnet or ferrous element and the target element attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device. The dose information capture device includes a magnetic position sensor adapted to detect a position of the target element. As an alternative to magnetic sensing, MEMS flow sensors, and the like may also be used. Exemplary systems preferably transmit dose information in real time to remote devices for further processing.

The inhalation therapy assembly and method of use described herein increases the efficiency of metered dose inhalers by allowing delivery of the doses to a collapsible reservoir which can be manually pumped, ensuring that medicants contained therein are properly and completely delivered to the patient. Terminal and proximal valves of the one-way diaphragm type allow flow of the aerosol medicants while preventing improper expulsion. An exhalation valve is adjustable to ensure the patient exhales suitably to permit proper medicant absorption. A conventional metered dosage inhaler having an approved FDA canister provides proper dosage to the patient and is joined to the collapsible reservoir by a connector having a plurality of apertures for receiving the MDI and an accessory T-fitting.

Embodiments of the disclosure include a transponder for determining a characteristic of a dose delivery device. The transponder may include a first sensor configured to detect a first parameter of the dose delivery device based on movement of at least one of the dose delivery device or a medicament contained within the dose delivery device, wherein the first sensor is configured to generate a first signal indicative of the first parameter. The transponder may include a processor operably coupled to the first sensor and configured to process the first signal. The transponder may include an indicator unit operably coupled to the processor and configured to generate an output based on the first signal, wherein the output is perceivable by a user. The transponder may also include a battery configured to provide power to at least one of the first sensor, the processor, and the indicator unit.

A system for capture of dose delivery information is provided. The system includes a medication delivery device, a dose information capture device adapted to he attached to the medication delivery device, and a target element adapted to be attached to the medication delivery device. The target element comprises a magnet or ferrous element and the target element attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device. The dose information capture device includes a magnetic position sensor adapted to detect a position of the target element. As an alternative to magnetic sensing, MEMS flow sensors, and the like may also be used. Exemplary systems preferably transmit dose information in real time to remote devices for further processing,

A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module (4) is user selectable so that it will deliver a priming dose of a primary medicament or both the primary and secondary medicaments. The module (4) also contains a needle guard (42) that locks after dose delivery. The needle guard (42) prevents accidental needle sticks before and after an injection. A locking collar (66) rotates during use as an inner protrusion (12) follows three paths (14, 15, 16) of a track (13) located on the outer surface of a body housing (10). When the inner facing protrusion (12) is in the third path (16), it encounters a hard stop and a rotational bias that locks the guard (42) from further retraction and thus covers the sharp distal end of the needle (3).

The invention relates to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams mapped so as to pass through the at least one non-target volume are limited such that the second term is zero only if the weights of beamlets passing through the at least one non-target volume are zero. This limit helps to avoid the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function using matrix inversion. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.

A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module (4) does not require the user to manually engage a reservoir (22) containing the secondary medicament. Instead, a biasing member (48) automatically activates the reservoir (22) when the needle guard (42) is retracted. The needle guard (42) prevents accidental needle sticks before and after an injection, and locks after dose delivery.

A dose counter device for an inhaler registers when a dose is delivered. The dose counter is adapted to mount on the distal end of the inhaler. The inhaler includes a canister comprising an inhaler housing. The dose counter device comprises a device trigger provided in an electron circuit on the distal end of the canister. The electron circuit further comprises an acoustic sensor also provided on the distal end of the canister. A force sensor is adapted to activate the acoustic sensor when a force is applied to the distal end of the canister. The acoustic sensor registers dose delivery when it picks up a sound.

A dose delivery device is disclosed where a dose can be set by rotating a dose setting member, whereby a push button is elevated from one end of the device a distance proportional to the set dose from a position fixed relative to the housing, and where the set dose can then be injected by pressing the push button back to its non-elevated position, through which motion a piston rod will move the same or a different distance due to a gearing mechanism being provided between the push button and the piston rod, where the gearing mechanism includes at least a first and a second thread on one or more parts that are rotationally coupled to each other, the first thread engaging a driver, the second thread engaging an element rotationally locked to the driver, one of the threads of the gearing mechanism being left-handed and the other one being right-handed.

A supplemental device (2) for attachment to an injection device (1) comprises: a display (21); a processor arrangement (24); a dose dialed detector (25) operable to detect a dose of medicament dialed into an attached injection device (1); a dose delivery determiner (27) for determining that a dose of medicament has been delivered (24, 25); a quantity determiner determining a quantity of medicament that has been delivered; and a clock configured to determine a current time. The processor arrangement (24) is configured when the supplemental device is in a default mode to display both a quantity of medicament that was delivered since a last dose and a time elapsed since delivery of the last dose.

A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module does not require the user to manually engage a reservoir (22) containing the secondary medicament. Instead, a biasing member (48) automatically activates the reservoir when the needle guard (42) is retracted. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery.

A drug delivery device (1; 100; 200) comprising a housing (2; 102; 201, 202), a dose setting mechanism operable to set a dose to be delivered from a variable volume reservoir, and a dose delivery structure (60; 160; 260) activatable to expel a set dose. The dose setting mechanism comprises a dose indicating structure (40; 140; 240) for indicating a size of the set dose. The dose indicating structure (40; 140; 240) is coupled with the dose delivery structure (60; 160; 260) during expelling of the set dose and moved relative to the housing (2; 102; 201, 202) to a zero dose indicating position. The zero dose indicating position is a position which is fixed with respect to the housing (2; 102; 201, 202). The dose setting mechanism further comprises a dose setting structure (20; 120; 220) movable in a dose preparing direction relative to the housing (2; 102; 201, 202) to a dose prepared position to set a dose of a first size. The dose prepared position is a position along the dose preparing direction which is fixed with respect to the housing (2; 102; 201, 202). The dose setting structure (20; 120; 220) and the dose indicating structure (40; 140; 240) are coupled and configured to undergo first correlated displacements relative to the housing (2; 102; 201, 202) during movement of the dose indicating structure (40; 140; 240) to the zero dose indicating position and further coupled and configured to undergo second correlated displacements relative to the housing (2; 102; 201, 202) during movement of the dose setting structure (20; 20; 220) to the dose prepared position, where the first correlated displacements and the second correlated displacements are mutually reverse. Further, when the dose setting structure (20; 120; 220) is in the dose prepared position the dose indicating structure (40; 140; 240) is selectively displaceable relative to the housing (2; 102; 201, 202) while the dose setting structure (20; 120; 220) remains stationary in the dose preparing direction to allow adjustment of the dose of the first size and thereby setting of a dose of a second size.

A container includes, in one embodiment, an outer housing holding a first mass of a first component of a composition, an inner housing holding a second mass of a second component of the composition, and a seal. The first component is a liquid and the mass of the second component conforms to a bottom and side wall of the inner housing. An interference fit exists between the outer housing and the inner housing such that the inner housing seals the first mass within the first chamber. The inner housing has an aperture in a side wall of the second chamber.

The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing (205), a dose dial component (104) positioned in the housing (205) and rotatable during dose setting and dose delivery, a clutch (105) rotatable during dose setting and non-rotatable during dose delivery having, preferably located at a distal end, clutch teeth (109), and a clutch ring (102) engaged with the housing (205) in a first rotatable configuration and in a second non-rotatable configuration.

This invention relates to apparatus and methods of delivering various compositions including medicaments to a variety of targets. The invention includes a dose administrator (1) which may be used for intranasal delivery of compositions or medicaments, such as live virus vaccines, to both humans and animals. An axial collapse prevention element (2) to prevent excessive axial deflection of the dose administrator (1) or a dose-location coordinate indicator (3) to facilitate the delivery of a dose to the desired target location may be coupled to the dose administrator (1). An intranasal probe (4) having a force dissemination contact surface (7) may be responsive to a first end of the dose administrator (1). The dose may be delivered from a conformable dose sequestration element (10) through an aperture which penetrates the dose delivery aperture element (5) and the dose may be caused to stream by coupling a stream delivery element (6) to the dose delivery aperture element (5). The force application element (12) which acts upon the dose may be separated from the dose by a fluid dose propellent (13). While the invention may be used for numerous applications, it specifically addresses the difficulties of delivering cold-adapted live equine influenza viruses intranasally to equids.