208 results about "Therapeutic effectiveness" patented technology

A method and apparatus for facilitating placement and evaluation of virtual appliances on virtual teeth of an orthodontic patient are described. Positioning references comprising bracket height, occlusal plane, or any arbitrary plane are provided to facilitate desired placement of virtual appliances on virtual teeth model. The process can be applied with any dentition state of a patient such as malocclusion, target state from treatment, or intermediate monitored state during the course of a treatment. An unified workstation for treatment planning provides the computer software tools for verification, simulation and evaluation of the virtual appliance placement. The process enables proper planning of treatment for an orthodontic patient suffering from malocclusion involving bonding of virtual brackets to the surface of the patient's virtual teeth with archwires placed in the slots of the brackets, so as to realize the desired results from the treatment in the most desired manner.

Sets, kits or stocks of anti-myopia contact or spectacle lenses, along with methods for their use, that do not require a clinician to measure peripheral refractive error in the eyes of myopic patients. Extensive surveys have shown that lenses having peripheral powers or defocus set in accordance with central corrective power will cover almost all normal myopes not worse than −6D central refractive error. In one example, a kit or set of lenses (50, FIG. 15) can have multiple parts or sub-sets (52, 54) each comprising a compartmented container (56a, 56b) with lenses (58a, 58b) arranged according to increments of central corrective power (59a, 59b). The lenses (58a) of the first part (52) have four steps (60a, 61a, 62a, 64a) of peripheral power or defocus to pro vide therapeutic effect and, while the lenses (58b) of the second part (54) also have four steps (60b, 61b, 62b, 64b), the level of therapeutic effect is higher. Other examples of sets, kits and stocks, as well as examples of lenses themselves, are disclosed together with methods of use.

The present invention provides pharmacogene polymorphisms and their use in predicting therapeutic effectiveness. The present invention also provides methods comprising targeted analysis of selected pharmacogenes in thousands of compiled whole human genome sequences for identifying polymorphic sequences associated with drug response are described. The methods also provide confirmation and validation of these pharmacogene polymorphisms, based on concordance between different sequencing technologies, and statistical error-checking. Imputation of the deleterious consequences of novel variants is predicted by bioinformatics analysis.

The present invention provides methods of detection, including early detection, for cancer or other diseases and normal physiologic processes mediated by global epigenetic changes, by using one or more of the following biomarkers: a global DNA methylation index, a global histone H4 acetylation index, and a global histone H4 trimethylation index. These methods are useful for, among other things, assessing the effectiveness of treatment, monitoring relapse, and clinical staging of cancer and other chronic as well as acute diseases. These methods are also useful for among other things monitoring the effectiveness of strategies and therapies used to modify lifestyle and contextual effects to prevent disease, foster wellness and enable health promotion.

The present invention relates to a method for the treatment of depression comprising administering a therapeutically effective amount of gaboxadol to a patient, wherein the level of one or more inflammatory markers in said patient is increased or abnormal. The present invention also relates to a method for the treatment of stress-mediated depression comprising administering a therapeutically effective amount of gaboxadol to a patient, wherein the level of one or more inflammatory markers is increased or abnormal in said patient. The present invention also relates to a method for the treatment of depression or the amelioration of one or more depressive symptoms comprising administering a therapeutically effective amount of gaboxadol to a patient, wherein the clinical presentation of one or more symptoms of depression are the physiological effect of a general medical condition. Furthermore the present also relates to a method for testing the therapeutic effectiveness of a compound in the treatment of depression or reducing the symptoms of depression comprising measuring the amount of one or more inflammatory markers in a sample from a patient before said compound is administered to the patient and comparing with the amount of said one or more inflammatory markers in a sample from the same patient after administration of said compound to the patient.

The invention discloses an automatic drug checking system based on an electronic anamnesis, which comprises a bar code scanner, an electronic anamnesis system communication interface, a drug checking system communication interface, a communication module, an input module, a display module and a controller, wherein the bar code scanner, the communication module, the input module and the display module are all connected to the controller; and the controller communicates with the electronic anamnesis system interface and the drug checking system communication interface through the communication module. According to the invention, a patient can check whether purchased drugs are consistent with a prescription in the anamnesis of the patient, whether the quality of the purchased drugs has problems and the like through the system; therefore, the phenomenon that wrong drugs are obtained by mistake of personnel or the drugs of poor quality are purchased is avoided to occur; and thereby, a treating effect on the patient is ensured.

The present invention relates to the use of MRI monitoring of ventricular enlargement rate as an objective measure for the purpose of assessing disease progression in patients suffering from Alzheimer's disease and for the purpose of determining therapeutic effectiveness of a treatment regimen for Alzheimer's patients. Methods for treating Alzheimer's Disease and monitoring therapeutic effectiveness are provided.

The invention discloses a hypertension patient monitoring method based on a grassroots medical platform. The hypertension patient monitoring method comprises that the grassroots medical platform monitors the blood pressure value of a user at the preset time with a preset monitoring period according to a user diagnosis and treatment plan acquired from a network hospital platform; the grassroots medical platform compares the blood pressure value of the user at the preset time with the blood pressure threshold at the corresponding time in the user diagnosis and treatment plan, and the comparison result within the preset monitoring period is recorded; the grassroots medical platform determines a blood pressure monitoring result within the monitoring period according to the comparison result within the preset monitoring period, and sends a blood pressure adjusting plan corresponding to the blood pressure monitoring result to the user in order to make the user execute the blood pressure adjusting plan. The invention also discloses a grassroots medical platform. The grassroots medical platform is in butt joint with the network hospital platform, parameter monitoring, prompting and intervention are carried to a hypertension patient according to the user diagnosis and treatment plan, and therefore the treatment progress of the hypertension patient is accelerated, and the treatment effect of the hypertension patient is improved.

The present invention relates to a method for diagnosis of different stages of endometrial cancer in an individual. Further, the present invention relates to a method for evaluating the probability of survival for an individual suffering from endometrial carcinoma. In another aspect, the present invention relates to the stratification of therapy regimen of endometrial tumor, ovarian cancer, breast cancer, non-small lung cancer or hormone refractory prostate cancer therapy in an individual or monitoring therapeutic efficacy in an individual suffering from the same based on the expression status of STMN1 gene or protein. Moreover, the present invention relates to a kit for use in any of the above referenced methods comprising a means for determining amplifications and deletions of chromosomal regions 3q26.32 and 12p12.1, determining alterations of the gene expression profile of the genes (gene signature): upregulation of the genes PLEKHK1, ATP10B, NMU, MMP1, ATAD2, NETO2, TNNI3, PHLDA2, OVOL1 and down-regulation of the genes: NDP, KIAA1434, MME, CFH, MOXD1, SLC47A1, RBP1, PDE8B, ASRGL1, ADAMTS19, EFHD1, ABCA5, NPAS3, SCML1, TNXB, ENTPD3, AMY1A, ENPP, RASL11B, PDZK3, or the expression status of the STMN1 gene or protein, respectively. Finally, the present invention provides a method for predicting the response to taxanes in an individual suffering from a disease treated with the taxanes based on the expression status of the STMN1 gene or protein.

A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease.

The invention relates to a ciclopirox olamine pessary capable of reducing toxic and side effects of a medicament caused by systemic delivery, increasing local concentration of the medicament, fully playing the therapeutic effectiveness of the medicament and improving the adaptability of patients. The pessary can realize zero order release and is prepared by the following materials by weight portion: 1 portion of ciclopirox olamine, 65 to 90 portions of substrate, 0.2 to 3 portions of stearic acid, 0.1 to 5 portions of hydrogenated castor oil and 0.05 to 2 portions of sodium benzoate.

The invention relates to an olive tablet and the preparation method. The olive tablet is made by the following raw materials according to the weight percentage: emblic leafflower finemeal of 40 percent to 48 percent, rock candy powder of 50 percent to 60 percent, menthol of 0.1 percent to 0.3 percent, vanillin of 0.1 percent to 0.3 percent, protein candy of 0.1 percent to 0.3 percent, stearic acid of 1.0 percent to 2.0 percent and lemon flavor of 0.1 percent to 0.3 percent. The olive tablet of the invention has the advantages of sweet taste, body fluid production and long aftertaste; and the olive tablet is suitable for long-term consumption, and has the unique therapeutic effectiveness of throat smooth, lung moistening and fast effect, thereby which is an essential health product at home and for travel.

The present invention relates generally to a population of cells genetically modified to comprise pancreatic islet glucokinase and capable of producing insulin in a glucose responsive manner and uses thereof. More particularly, the present invention relates to a population of cells so genetically modified capable of producing insulin in response to physiologically relevant levels of glucose and uses thereof. The cells of the present invention are useful in a wide variety of applications, in particular in the context of therapeutic and prophylactic regimes directed to the treatment of diabetes and/or the amelioration of symptoms associated with diabetes, based on the transplantation of the cells of the present invention into mammals requiring treatment. Also facilitated is the design of in vitro based screening systems for testing the therapeutic effectiveness and/or toxicity of potential adjunctive treatment regimes.

A head rehabilitation system and a multifunctional cervical vertebra parting therapy apparatus formed by the same; the head rehabilitation system comprises an upper fixed plate, a rotary mechanism and a drawing mechanism; the rotary mechanism comprises a rotary motor fixed on the upper fixed plate; the rotary motor output end is provided with an adjusting disc. One end of a universal coupling is arranged in an adjusting disc groove, i.e., drifts away from the adjusting disc center; the rotary motor drives the adjusting disc to rotate; the adjusting disc drives one end of the universal coupling to swing; the universal coupling motions comprise vertical directions and horizontal directions; the universal coupling drives a swing rod to make synthesis motions in opposite directions; a middle frame and a heat cap swing with the swing rod; the head cap makes swing motions similar to a horn type; a drawing motor draws the head cap through a drawing belt, so a patient can synchronically swing in traction treatment, and the head can make multidirection motions; the system is large in motion amount and good in treatment effect; the vibration amplitude of the head cap can be adjusted according to the position of the universal coupling on the adjusting disc; the head rehabilitation system is suitable for different patients.

The invention discloses a staggered massaging type cervical vertebra rehabilitation treatment device. The staggered massaging type cervical vertebra rehabilitation treatment device comprises an arc-shaped hollow plate, a belt wheel, a hollow column, massaging balls, a connecting rod, a driving device and a head back supporting device. The rehabilitation treatment device has the beneficial effects that a jacking bolt is screwed off and screwed on to adjust the height of a head back supporting plate, so that patients with different body forms can utilize the rehabilitation treatment device relatively comfortably; the connecting rod circularly moves up and down, so that the massaging balls can be used for carrying out hammering type massaging on necks of the patients when the massaging balls are located on the uppermost side; the massaging balls are used for massaging the necks of the patients in a staggered manner and the massaging efficiency is improved; three continuous U-shaped rotary rods are arranged, so that the necks of the patients can be massaged at a plurality of angles at the same time; in a massaging process, an electric heating rod is used for heating and medicine liquid injected into a medicine liquid cavity is heated; and medicine liquid gas at a certain temperature overflows through a gas medicine through hole, and medicines are applied to cervical vertebras of the patients, so that the cervical vertebra rehabilitation effect on the patients is relatively good.

The present invention relates to the use of the level of certain cytokines in a patient's blood as an objective measure for the purpose of assessing disease progression in patients suffering from Alzheimer's disease and for the purpose of determining therapeutic effectiveness of a treatment regimen. Methods for treating Alzheimer's disease and monitoring therapeutic effectiveness are provided.

The present invention relates to a biliary tract interior support frame containing medicine and its preparation method. Said biliary tract interior support frame includes tubular supporting tube which can open cavitary tract of biliary duct and is equipped with several medicine-releasing holes. The inner wall of the invented tubular supporting tube has a layer of medicine-stored layer made up by mixing medicine and excipient. Several biliary tract interior suppert frames can be series-connected together. Said invention also provides the concrete steps of its preparation method.

The present invention provides uses of a glucagon-like peptide 1 receptor agonist in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose, and improving the therapeutic effectiveness of metformin. The invention also provides pharmaceutical compositions that comprise a GLP1R agonist and metformin.

The present invention is directed to an all-fiber-optic scanning endomicroscope capable of high-resolution second harmonic generation (SHG) imaging of biological tissues. The endomicroscope has an overall 2.0 mm diameter and consists of a single customized double-clad fiber, a compact rapid two-dimensional beam scanner, and a miniature compound objective lens for excitation beam delivery, scanning, focusing, and efficient SHG signal collection. Endomicroscopic SHG images of murine cervical tissue sections at different stages of normal pregnancy reveal progressive, quantifiable changes in cervical collagen morphology with resolution similar to that of bench-top SHG microscopy. A device according to an embodiment of the present invention can also be used to assess other pathologies, such as cancer. fibrosis, and inflammation. The present invention allows for diagnosis, monitoring of the effect of therapeutics, and surgical or interventional guidance. The present invention enables visualization of histology in-vivo, in the patient, and is label-free.

A system that executes a process for mapping cardiac fibrillation and optimizing ablation treatments. The process, in some embodiments, includes: positioning a two dimensional electrode array to several locations in a patient's heart and at each location, obtaining a conduction velocity and a cycle length measurement from at least two local signals in response to electrical activity in the cardiac tissue. In some embodiments, a regional wavelength is calculated by multiplying the local conduction velocity with the local minimum cycle length. The system can then create a wavelength distribution map that identifies the location of the drivers in the heart. In certain embodiments, the system uses variability of conduction velocity and cycle length in an area to determine the driver type. In some embodiments, the system calculates average distance of drivers to non-conductive tissue boundaries. The system then selects ablation placements that maximize treatment efficacy while minimizing tissue damage.

The invention provides a medicine recommending method. The medicine recommending method includes the steps: monitoring the medicine taking cycle of a patient, and sending an evaluation request to a patient terminal in the preset time interval when the medicine taking cycle of the patient is over; receiving the evaluation information, corresponding to the evaluation request, fed back from the patient terminal, and acquiring the patient information contained in the evaluation information and the curative effect information of the taken medicine for the patient; and analyzing each received evaluation information to determine a plurality of different patient groups, establishing a curative effect information table of different medicines, corresponding to each patient group, and according to the curative effect information table, recommending the corresponding medicine to the patient waiting for seeking medical advice. The medicine recommending method can establish the curative effect information table of different medicines corresponding to different patient groups by analyzing the evaluation information of the medicines, fed back from each patient, so as to recommend medicines suitable for the patients according to the personal information of the patients seeing doctors and improve the curative effect of the patients.