108 results about "Ocular tissue" patented technology

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a grasping body having a longitudinal axis, and a piercing member coupled to the grasping body, including an elongate body and a beveled piercing tip including a long side and a short side, wherein the piercing member includes a proximal segment, a distal segment, and an aperture nested between the proximal segment and the distal segment, wherein the short side and the aperture are coaxially disposed along a central longitudinal axis of the piercing member, and wherein the piercing member is configured to reciprocate along the longitudinal axis relative to the grasping body.

A medical device for office-based / operating room bleb forming minimally invasive glaucoma surgeries. The medical device includes a proximal segment for grasping by a user, a distal segment that includes a piercing member coupled to and extending from the distal segment, wherein the piercing member is configured to contain and deliver an ocular implant into an eye tissue layer to obtain a channel, wherein the proximal segment and the distal segment being configured to couple to each other at a pivot point between an unlocked configuration and a locked configuration, and wherein in the unlocked configuration, the proximal segment and the distal segment are rotatable relative to each other about a rotation axis at the pivot point.

The invention relates to the field of surgical robots, and particularly discloses an intraoperative risk assessment system for a cataract surgical robot, comprising: a patient biomechanical monitoring unit for collecting a contact force between an instrument and an eye tissue, and calculating an anterior chamber equivalent pressure value according to an axial force component of the contact force and a contact area between the instrument and a cornea; the patient optical imaging monitoring unit is used for collecting microstructure images of the cornea and the lens capsule and quantifying the energy release density of ultrasonic emulsification; the robot motion parameter monitoring unit is used for collecting joint motion resistance, instrument tail end three-dimensional coordinates, motion speed and attitude angle of the robot; the multi-mode joint reasoning unit is used for identifying a high-risk operation state when the contact force is higher than a first preset value and the energy release density is higher than a second preset value; by adopting the technical scheme of the invention, multi-dimensional real-time monitoring can be realized, and a dynamic risk prediction model can be established by fusing heterogeneous data through an intelligent algorithm.

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

The present invention relates to a small molecule polypeptide for preventing and treating inflammation. The present invention also relates to methods for preparing and using the small molecule polypeptide, as well as pharmaceutical compositions containing the polypeptide. The polypeptide of the present invention has multiple advantages, such as a small molecular weight that allows it to penetrate various ocular tissue barriers; good water solubility, and the ability to maintain high concentrations in neutral tears, aqueous humor, and vitreous humor.

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a body for grasping, a piercing member including a proximal segment and a distal segment, the distal segment including a piercing tip at a distal end thereof, and a distal stabilizer element extending from a distal end of the body, the distal stabilizer element including a lumen, wherein the piercing member is configured to reciprocate from a stored position, wherein the proximal segment is retracted within the stabilizer lumen and the piercing tip extends outwardly from the stabilizer, and an extended position, wherein the distal segment and at least a portion of the proximal segment extend outwardly from the stabilizer.

Provided is a composition for visual field defect disorders, glaucoma, light-induced ocular tissue damage and related disorders, which can be used as a food or drug for long-term administration, prevention, symptom relief and improvement. A composition comprising a triglyceride represented by the formula (I):(wherein R1, R2, and R3 are each a saturated fatty acid residue, and at least one of them is a pentadecanoic acid residue) as an active ingredient.

The invention discloses pranoprofen temperature-sensitive gel for treating xerophthalmia and a preparation method, the gel takes poloxamer 407 and poloxamer 188 as matrixes, the optimal ratio of the poloxamer 407 to the poloxamer 188 is 23.5%: 2%, and the ratio is optimized and determined by a central composite design-response surface method. During preparation, a blank gel solution is prepared firstly, and then auxiliary materials such as pranoprofen and the like are added for dissolution. The in-vitro release characteristic is good, the accumulated dissolution rate within 210 min exceeds 90%, and the zero-level pharmacokinetic process is achieved. An SD rat xerophthalmia model is established, and it is proved that the xerophthalmia treatment effect of the composition is better than that of eye drops. In eye tissue distribution and aqueous humor pharmacokinetic studies, higher target organ distribution characteristics are shown, the aqueous humor AUC0-t is 1.85 times that of eye drops, and the bioavailability is high. The invention further provides a gel preparation method, a drug effect evaluation method and a related research method, and a new effective dosage form and a new treatment thought are provided for xerophthalmia treatment.

A method and system delivers customizable microcurrent stimulation to ocular tissue using a three half-bridge driver circuit. The system includes a control circuit that selectively switches high-side and low-side transistors, such as MOSFETs, to generate various electrical waveforms, such as stepped, asymmetric biphasic, pulsed, and triangular waveforms. These waveforms are applied to electrodes in contact with the eye for therapeutic treatment, addressing conditions like age-related macular degeneration (AMD) and other ocular disorders. The system allows for adjustments in amplitude, frequency, and duration of the waveforms, providing personalized treatment protocols tailored to patient-specific needs. High-impedance periods are included between pulses to promote tissue recovery and enhance patient comfort. Additionally, a non-transitory computer-readable storage medium stores a program that controls the system, enabling real-time waveform generation and dynamic adjustment during treatment. This approach offers a flexible and efficient solution for ocular therapy, improving both treatment outcomes and patient experience.

This invention relates to the use of recombinant type III humanized collagen and compositions comprising thereof in the ocular field. The invention provides the use of recombinant type III humanized collagen in the preparation of products for the prevention and / or treatment of ocular inflammation, and compositions comprising recombinant type III humanized collagen, and the use of these compositions in the preparation of products for the prevention and / or treatment of ocular inflammation and / or dry eye. Recombinant type III humanized collagen and compositions comprising thereof can significantly promote the renewal and repair of corneal epithelial cells, while inhibiting the release of inflammatory mediators, strengthening the ocular tissue barrier, enhancing tear film stability, and relieving ocular inflammation and dry eye.

The invention relates to a high-steam-quantity self-heating body and a steam eyeshade, the self-heating body comprises a nutrition layer and a heating layer, the nutrition layer is distributed on the inner side of the heating layer, and a temperature control breathable film I is arranged between the nutrition layer and the heating layer. The steam eyeshade has the advantages that the structure is simple, design is reasonable, the steam amount of the steam eyeshade can be obviously increased through the double-bag design, the physical thermal therapy effect is achieved, tear circulation and tear secretion are promoted, the nutritional condition of eye tissue is improved, and a certain effect is achieved for treating xerophthalmia.

A method of treating an eye includes delivering an OCT beam along an OCT optical path that enters a first optical subsystem along an input axis, and exits the first optical subsystem along an output axis that: 1) is substantially parallel to the optical axis of the eye, 2) is radially offset from the optical axis, and 3) extends through the cornea and into a portion of the irido-corneal angle at a point along a circumferential angle of the eye. The method also includes imaging the portion of the irido-corneal angle with the OCT beam; delivering a laser beam along an angled optical path that extends through the first optical subsystem, through the cornea, through the anterior chamber, and into a target volume of ocular tissue in the portion of the irido-corneal angle; and photodisrupting at least a portion of the target volume of ocular tissue with the laser beam.

This invention relates to a biopsy needle for trabecular meshwork tissue of the eye, belonging to the field of medical device technology. It solves the problem of large incisions caused by the large surgical incisions in traditional trabeculectomy procedures, where a scalpel is used to cut a block of ocular tissue containing the trabeculae and deep cornea and sclera. The invention includes a needle, a scraper unit, and a handle. The needle is connected to the handle, the scraper unit is disposed within the needle, and the handle is for the user to hold. The needle is inserted into the patient's eyeball, and the scraper unit is used to cut the trabecular meshwork and Schlemm's canal wall tissue. The scraper unit of this invention is a bendable scraper unit. The first, second, and third sections can form grooved hooks for hooking the trabecular meshwork and Schlemm's canal wall tissue. The grooved hooks of this invention are specifically designed to hook the trabecular meshwork and Schlemm's canal wall tissue, resulting in minimal trauma to the ocular incision.

The invention discloses a three-dimensional reconstruction method and system for eye tissue, medical equipment and a storage medium. The method comprises the steps that at least two OCT images are acquired; determining a tissue boundary line of the target eye tissue based on the at least two OCT images; generating a mask of the target eye tissue based on the at least two OCT images; and generating a three-dimensional reconstruction model of the target eye tissue based on the tissue boundary line and the mask.

Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.

In some embodiments, an ophthalmic surgical feedback system includes a laser device configured to emit light to a location on eye tissue of a patient and generate biomechanics information for the location based on the light. The ophthalmic surgical feedback system also includes a memory having executable instructions and a processor in communication with the laser device and the memory. The processor is configured to execute the instructions to determine strength of the eye tissue at the location based on the biomechanics information. The processor is further configured to execute the instructions to generate feedback related to utilization of a surgical instrument at the location based on the determined strength.

The invention relates to a pathological biopsy needle for eye trabecular meshwork tissue, belongs to the technical field of medical instruments, and solves the problem that in the traditional trabectomy in the prior art, an eye tissue block containing trabecula and deep sclera is cut by a surgical blade, and the trauma of an eye incision is large. The device comprises a needle head, a scraper unit and a handle, the needle head is connected with the handle, the scraper unit is arranged in the needle head, the handle is used for being held by a user, the needle head is used for being inserted into an eyeball of a patient, and the scraper unit is used for cutting trabecular mesh and Schlemm tube wall tissue. The scraper unit is a bendable scraper unit, the first section, the second section and the third section can form a hook part with a groove, and the hook part with the groove is used for hooking trabecular meshes and Schlemm pipe wall tissues. The hook part with the groove is specially aligned to trabecular meshes and Schlemm tube wall tissues for hooking, and the trauma of an eye incision is small.

The device of the present invention allows for a method of treating a patient exhibiting proptosis of eye tissue by treating inflamed tissue behind the eye or treating the thyroid directly or treating a reflexology zone to reduce pressure and inflammation of the eye tissue using pressure pulses or shock waves. The treatment method for bulging eyes has the steps of placing an applicator head of an acoustic shock wave or pressure pulse generator or source on or near an eye or eyelid region, temple, thyroid or reflexology zone; coupling the applicator head directly or indirectly to an exposed surface of the region being treated; and activating the generator or source to emit pressure pulses or acoustic shock waves to the eye or eyelid region, temple, thyroid or reflexology zone to treat the eye tissue exhibiting high pressure and inflammation to reduce the pressure and inflammation.

Disclosed is a glaucoma device (10, 1010) comprising: an implant body (15, 1015) including an anterior portion (20, 1020), a distal portion (35, 1035), a plurality of arms (40, 1040) extending between the anterior portion (20, 1020) and the distal portion (35, 1035) to provide connection therebetween; and a fluid network extending from the anterior portion (20, 1020) along at least one of the arms (40, 1040) to the distal portion (35, 1035), the fluid network providing a plurality of outlet channels (90, 1090) for fluid exit therefrom; and a fluid inlet cannula (30, 1030) arranged on the anterior portion (20, 1020) of the implant body (15, 1015) and adapted for fluid connection with ocular tissue.

Embodiments of the present invention disclose a method, system, electronic device, and storage medium for determining ocular tissue information. The method comprises: injecting prepared magnetic nanoparticles into the eye region and adjusting the eye region to the light beam exit position of a data acquisition system; the eye region includes the cornea, sclera, lens, ciliary muscle, and / or retina; applying a controllable voltage to an electromagnetic coil in an excitation system so that the electromagnetic coil generates a controllable magnetic field based on the controllable voltage to drive the magnetic nanoparticles in the eye region; and transmitting a laser beam based on a laser in the data acquisition system so that the laser beam enters the eye region from the light beam exit position, and receiving a reflected light beam fed back from the eye region to obtain target ocular tissue data; and analyzing and processing the target ocular tissue data to obtain mechanical characteristic parameters corresponding to the eye region. The present invention can improve the comfort of the subject being measured during the measurement process.

An ab externo automated laser treatment system for treating an eye in a subject, includes a non-contact laser source configured to generate a laser beam having at least one wavelength to treat the eye by directing the laser beam from a location spaced from the eye, wherein the at least one wavelength is a near-infrared wavelength in the range of about 0.5-2.2 μm, a laser scanner optically coupled to the non-contact laser source to receive the laser beam from the non-contact laser source and to scan the laser beam relative to the eye, and a processor, and memory including stored computer-readable instructions that, responsive to execution by the processor, cause the laser treatment system to direct the laser beam to a plurality of trans-scleral treatment locations to be irradiated in a predetermined treatment pattern on an external surface of the eye, wherein the trans-scleral treatment locations are 0-4 mm posterior to the corneolimbal junction, and wherein the laser beam is repetitively directed to the same irradiated trans-scleral treatment locations on the surface of the eye, and the trans-scleral treatment locations are irradiated at intervals sufficient to induce protective thermal preconditioning and therapeutic bio-stimulation of one or more of the trabecular meshwork and / or ciliary body without photocoagulation of the tissue of the eye. Trans-pupillary systems, patient interfaces, and methods are also disclosed.

The utility model provides an iris dilation ring, which relates to the technical field of ophthalmologic operation related equipment, and comprises a dilation ring body and a connecting band assembly, the dilation ring body is of an unclosed circular ring structure, and the dilation ring body is used for penetrating through an incision of an eyeball and being attached to an iris so as to assist in dilation of the iris; the connecting belt assembly is detachably connected with the dilation ring body, and the connecting belt assembly is arranged on the outer side of the incision so as to prevent the dilation ring body from falling off from the iris. The technical problem that in the prior art, when an eye operation is carried out, eye tissue is prone to being damaged is solved.

Apparatuses and methods for facilitating the guided delivery of a drug into a patient's body organ are disclosed. An apparatus (2500) for facilitating the guided delivery of a drug into a patient's body organ can include a container (2504) configured to package a drug, a needle (2502) having a passage therethrough and a sharp distal tip, and a needle sheath (2506) at least partially surrounding a shaft of the needle. The needle sheath can include a distal surface, wherein the sharp distal tip of the needle can be configured to extend through an opening in the distal surface. The needle sheath can be movable relative to the needle along an axis of the needle to control a distance from the distal surface to the distal tip of the needle.

An optical coherence tomography (OCT) scanning system for measuring ocular tissue characteristics of an eye of a patient. The system includes an OCT scanner configured to implement a scan sequence on ocular tissue that scans the ocular tissue with an optical signal to obtain OCT data based on a reflected version of the optical signal. The system includes a computer having a processor configured to provide a control signal to the OCT scanner to implement a sequence of scans and determine a rate of change of phase data or amplitude data associated with the scans. The system determines a growth constant for a reflected version of the optical signal based on a rate of change of the phase data or amplitude data, and determines a diffusion coefficient associated with the cornea based on the growth constant. The system determines quantitative parameters of the cornea based on the diffusion coefficients.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a body for grasping, a piercing member including a proximal segment and a distal segment, the distal segment including a piercing tip at a distal end thereof, and a distal stabilizer element extending from a distal end of the body, the distal stabilizer element including a lumen, wherein the piercing member is configured to reciprocate from a stored position, wherein the proximal segment is retracted within the stabilizer lumen and the piercing tip extends outwardly from the stabilizer, and an extended position, wherein the distal segment and at least a portion of the proximal segment extend outwardly from the stabilizer.

The application relates to a first-aid system for eye injury in a battlefield environment, which comprises a first-aid eye cover and a discrimination device; the first-aid eye cover comprises an eye cover body and an elastic band, wherein the eye cover body comprises a rigid eye cover layer and a flexible eye cover layer which are tightly connected; the eye cover body is provided with a plurality of through holes, and a pressure relief unit is arranged in the through holes; when the internal pressure of the eye cover body exceeds 30mmHg, the pressure relief unit automatically opens to release pressure outward, the pressure is restored to 30mmHg, and the pressure relief unit cannot be reversely opened; the discrimination device comprises a camera and an edge processor; the processor is used for receiving images collected by the camera. The application is simple and portable, can provide safe protection for an injured eye in a field or battlefield environment, realizes complete coverage of the injured eye, avoids pollution and ejection / herniation of the contents of the eye, effectively releases pressure when the pressure in the flexible eye cover is increased due to bleeding and edema of tissues with the development of the injury, avoids ischemic necrosis of eye tissues and orbital apex syndrome caused by excessively high pressure or excessively tight bandaging, and discriminates the severity of the injury, thereby being convenient for subsequent treatment.

Certain aspects of the present disclosure provide systems and methods for measuring ocular tissue biomechanics via blink stimulation. In some embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes monitoring movement relative to an eye of a patient via one or more images from a camera. The method also includes detecting a blink of the eye of the patient in response to the monitoring. The method further includes, in response to the detected blink, recording data resulting from a scan of at least a portion of the tissue of the eye by the OCT device. The method further includes measuring a response of the tissue to the detected blink based on the recorded data from the scan.

Disclosed are devices and methods for directed delivery of a medicament into ocular tissue. A device for delivering a medicament to ocular tissue may include a housing, a container configured to contain the medicament, and a needle in fluid communication with the container, and a carriage positioned within the housing and coupled to the container and the needle. The carriage may be translatable along the needle axis and the carriage may include a threaded outer surface. The device may further include a nut positioned within the housing and engaged with the threaded outer surface. Rotation of the nut may be configured to cause the carriage and the needle to translate in a distal direction along the needle axis.

The present invention belongs to the field of biotechnology, and discloses a capsid protein mutant that improves the infectivity of AAV to eye tissues and its application. By inserting AAVRFDGTERAA and RQYSDAVRAE at amino acid positions 587 and 588 corresponding to the wild-type AAV2 virus capsid protein, the capsid protein mutants AAV2-NE01 and AAV2-NE02 are obtained. The virus yields of AAV2-NE01 and AAV2-NE02 are 1.96 times and 1.20 times that of AAV2-WT. After intravitreal injection, they can preferably infect various layers of cells from the ganglion cell layer (GCL), inner nuclear layer (INL) to outer nuclear layer (ONL) of the NHP retina and the trabecular meshwork region, with a high infection positive rate, strong fluorescence intensity, strong retinal penetration ability, and can infect the nuclear part and inner segment of the optic nerve. It has good application prospects and is expected to be developed into an AAV vector for treating eye diseases.