78 results about "Ocular tissue" patented technology

A medical device for office-based / operating room bleb forming minimally invasive glaucoma surgeries. The medical device includes a proximal segment for grasping by a user, a distal segment that includes a piercing member coupled to and extending from the distal segment, wherein the piercing member is configured to contain and deliver an ocular implant into an eye tissue layer to obtain a channel, wherein the proximal segment and the distal segment being configured to couple to each other at a pivot point between an unlocked configuration and a locked configuration, and wherein in the unlocked configuration, the proximal segment and the distal segment are rotatable relative to each other about a rotation axis at the pivot point.

The invention relates to the field of surgical robots, and particularly discloses an intraoperative risk assessment system for a cataract surgical robot, comprising: a patient biomechanical monitoring unit for collecting a contact force between an instrument and an eye tissue, and calculating an anterior chamber equivalent pressure value according to an axial force component of the contact force and a contact area between the instrument and a cornea; the patient optical imaging monitoring unit is used for collecting microstructure images of the cornea and the lens capsule and quantifying the energy release density of ultrasonic emulsification; the robot motion parameter monitoring unit is used for collecting joint motion resistance, instrument tail end three-dimensional coordinates, motion speed and attitude angle of the robot; the multi-mode joint reasoning unit is used for identifying a high-risk operation state when the contact force is higher than a first preset value and the energy release density is higher than a second preset value; by adopting the technical scheme of the invention, multi-dimensional real-time monitoring can be realized, and a dynamic risk prediction model can be established by fusing heterogeneous data through an intelligent algorithm.

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

Provided is a composition for visual field defect disorders, glaucoma, light-induced ocular tissue damage and related disorders, which can be used as a food or drug for long-term administration, prevention, symptom relief and improvement. A composition comprising a triglyceride represented by the formula (I):(wherein R1, R2, and R3 are each a saturated fatty acid residue, and at least one of them is a pentadecanoic acid residue) as an active ingredient.

A method and system delivers customizable microcurrent stimulation to ocular tissue using a three half-bridge driver circuit. The system includes a control circuit that selectively switches high-side and low-side transistors, such as MOSFETs, to generate various electrical waveforms, such as stepped, asymmetric biphasic, pulsed, and triangular waveforms. These waveforms are applied to electrodes in contact with the eye for therapeutic treatment, addressing conditions like age-related macular degeneration (AMD) and other ocular disorders. The system allows for adjustments in amplitude, frequency, and duration of the waveforms, providing personalized treatment protocols tailored to patient-specific needs. High-impedance periods are included between pulses to promote tissue recovery and enhance patient comfort. Additionally, a non-transitory computer-readable storage medium stores a program that controls the system, enabling real-time waveform generation and dynamic adjustment during treatment. This approach offers a flexible and efficient solution for ocular therapy, improving both treatment outcomes and patient experience.

This invention relates to the use of recombinant type III humanized collagen and compositions comprising thereof in the ocular field. The invention provides the use of recombinant type III humanized collagen in the preparation of products for the prevention and / or treatment of ocular inflammation, and compositions comprising recombinant type III humanized collagen, and the use of these compositions in the preparation of products for the prevention and / or treatment of ocular inflammation and / or dry eye. Recombinant type III humanized collagen and compositions comprising thereof can significantly promote the renewal and repair of corneal epithelial cells, while inhibiting the release of inflammatory mediators, strengthening the ocular tissue barrier, enhancing tear film stability, and relieving ocular inflammation and dry eye.

A method of treating an eye includes delivering an OCT beam along an OCT optical path that enters a first optical subsystem along an input axis, and exits the first optical subsystem along an output axis that: 1) is substantially parallel to the optical axis of the eye, 2) is radially offset from the optical axis, and 3) extends through the cornea and into a portion of the irido-corneal angle at a point along a circumferential angle of the eye. The method also includes imaging the portion of the irido-corneal angle with the OCT beam; delivering a laser beam along an angled optical path that extends through the first optical subsystem, through the cornea, through the anterior chamber, and into a target volume of ocular tissue in the portion of the irido-corneal angle; and photodisrupting at least a portion of the target volume of ocular tissue with the laser beam.

This invention relates to a biopsy needle for trabecular meshwork tissue of the eye, belonging to the field of medical device technology. It solves the problem of large incisions caused by the large surgical incisions in traditional trabeculectomy procedures, where a scalpel is used to cut a block of ocular tissue containing the trabeculae and deep cornea and sclera. The invention includes a needle, a scraper unit, and a handle. The needle is connected to the handle, the scraper unit is disposed within the needle, and the handle is for the user to hold. The needle is inserted into the patient's eyeball, and the scraper unit is used to cut the trabecular meshwork and Schlemm's canal wall tissue. The scraper unit of this invention is a bendable scraper unit. The first, second, and third sections can form grooved hooks for hooking the trabecular meshwork and Schlemm's canal wall tissue. The grooved hooks of this invention are specifically designed to hook the trabecular meshwork and Schlemm's canal wall tissue, resulting in minimal trauma to the ocular incision.

The invention discloses a three-dimensional reconstruction method and system for eye tissue, medical equipment and a storage medium. The method comprises the steps that at least two OCT images are acquired; determining a tissue boundary line of the target eye tissue based on the at least two OCT images; generating a mask of the target eye tissue based on the at least two OCT images; and generating a three-dimensional reconstruction model of the target eye tissue based on the tissue boundary line and the mask.

Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.

The invention relates to a pathological biopsy needle for eye trabecular meshwork tissue, belongs to the technical field of medical instruments, and solves the problem that in the traditional trabectomy in the prior art, an eye tissue block containing trabecula and deep sclera is cut by a surgical blade, and the trauma of an eye incision is large. The device comprises a needle head, a scraper unit and a handle, the needle head is connected with the handle, the scraper unit is arranged in the needle head, the handle is used for being held by a user, the needle head is used for being inserted into an eyeball of a patient, and the scraper unit is used for cutting trabecular mesh and Schlemm tube wall tissue. The scraper unit is a bendable scraper unit, the first section, the second section and the third section can form a hook part with a groove, and the hook part with the groove is used for hooking trabecular meshes and Schlemm pipe wall tissues. The hook part with the groove is specially aligned to trabecular meshes and Schlemm tube wall tissues for hooking, and the trauma of an eye incision is small.

The device of the present invention allows for a method of treating a patient exhibiting proptosis of eye tissue by treating inflamed tissue behind the eye or treating the thyroid directly or treating a reflexology zone to reduce pressure and inflammation of the eye tissue using pressure pulses or shock waves. The treatment method for bulging eyes has the steps of placing an applicator head of an acoustic shock wave or pressure pulse generator or source on or near an eye or eyelid region, temple, thyroid or reflexology zone; coupling the applicator head directly or indirectly to an exposed surface of the region being treated; and activating the generator or source to emit pressure pulses or acoustic shock waves to the eye or eyelid region, temple, thyroid or reflexology zone to treat the eye tissue exhibiting high pressure and inflammation to reduce the pressure and inflammation.

Disclosed is a glaucoma device (10, 1010) comprising: an implant body (15, 1015) including an anterior portion (20, 1020), a distal portion (35, 1035), a plurality of arms (40, 1040) extending between the anterior portion (20, 1020) and the distal portion (35, 1035) to provide connection therebetween; and a fluid network extending from the anterior portion (20, 1020) along at least one of the arms (40, 1040) to the distal portion (35, 1035), the fluid network providing a plurality of outlet channels (90, 1090) for fluid exit therefrom; and a fluid inlet cannula (30, 1030) arranged on the anterior portion (20, 1020) of the implant body (15, 1015) and adapted for fluid connection with ocular tissue.

An ab externo automated laser treatment system for treating an eye in a subject, includes a non-contact laser source configured to generate a laser beam having at least one wavelength to treat the eye by directing the laser beam from a location spaced from the eye, wherein the at least one wavelength is a near-infrared wavelength in the range of about 0.5-2.2 μm, a laser scanner optically coupled to the non-contact laser source to receive the laser beam from the non-contact laser source and to scan the laser beam relative to the eye, and a processor, and memory including stored computer-readable instructions that, responsive to execution by the processor, cause the laser treatment system to direct the laser beam to a plurality of trans-scleral treatment locations to be irradiated in a predetermined treatment pattern on an external surface of the eye, wherein the trans-scleral treatment locations are 0-4 mm posterior to the corneolimbal junction, and wherein the laser beam is repetitively directed to the same irradiated trans-scleral treatment locations on the surface of the eye, and the trans-scleral treatment locations are irradiated at intervals sufficient to induce protective thermal preconditioning and therapeutic bio-stimulation of one or more of the trabecular meshwork and / or ciliary body without photocoagulation of the tissue of the eye. Trans-pupillary systems, patient interfaces, and methods are also disclosed.

The utility model provides an iris dilation ring, which relates to the technical field of ophthalmologic operation related equipment, and comprises a dilation ring body and a connecting band assembly, the dilation ring body is of an unclosed circular ring structure, and the dilation ring body is used for penetrating through an incision of an eyeball and being attached to an iris so as to assist in dilation of the iris; the connecting belt assembly is detachably connected with the dilation ring body, and the connecting belt assembly is arranged on the outer side of the incision so as to prevent the dilation ring body from falling off from the iris. The technical problem that in the prior art, when an eye operation is carried out, eye tissue is prone to being damaged is solved.

Apparatuses and methods for facilitating the guided delivery of a drug into a patient's body organ are disclosed. An apparatus (2500) for facilitating the guided delivery of a drug into a patient's body organ can include a container (2504) configured to package a drug, a needle (2502) having a passage therethrough and a sharp distal tip, and a needle sheath (2506) at least partially surrounding a shaft of the needle. The needle sheath can include a distal surface, wherein the sharp distal tip of the needle can be configured to extend through an opening in the distal surface. The needle sheath can be movable relative to the needle along an axis of the needle to control a distance from the distal surface to the distal tip of the needle.

An optical coherence tomography (OCT) scanning system for measuring ocular tissue characteristics of an eye of a patient. The system includes an OCT scanner configured to implement a scan sequence on ocular tissue that scans the ocular tissue with an optical signal to obtain OCT data based on a reflected version of the optical signal. The system includes a computer having a processor configured to provide a control signal to the OCT scanner to implement a sequence of scans and determine a rate of change of phase data or amplitude data associated with the scans. The system determines a growth constant for a reflected version of the optical signal based on a rate of change of the phase data or amplitude data, and determines a diffusion coefficient associated with the cornea based on the growth constant. The system determines quantitative parameters of the cornea based on the diffusion coefficients.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a body for grasping, a piercing member including a proximal segment and a distal segment, the distal segment including a piercing tip at a distal end thereof, and a distal stabilizer element extending from a distal end of the body, the distal stabilizer element including a lumen, wherein the piercing member is configured to reciprocate from a stored position, wherein the proximal segment is retracted within the stabilizer lumen and the piercing tip extends outwardly from the stabilizer, and an extended position, wherein the distal segment and at least a portion of the proximal segment extend outwardly from the stabilizer.

The application relates to a first-aid system for eye injury in a battlefield environment, which comprises a first-aid eye cover and a discrimination device; the first-aid eye cover comprises an eye cover body and an elastic band, wherein the eye cover body comprises a rigid eye cover layer and a flexible eye cover layer which are tightly connected; the eye cover body is provided with a plurality of through holes, and a pressure relief unit is arranged in the through holes; when the internal pressure of the eye cover body exceeds 30mmHg, the pressure relief unit automatically opens to release pressure outward, the pressure is restored to 30mmHg, and the pressure relief unit cannot be reversely opened; the discrimination device comprises a camera and an edge processor; the processor is used for receiving images collected by the camera. The application is simple and portable, can provide safe protection for an injured eye in a field or battlefield environment, realizes complete coverage of the injured eye, avoids pollution and ejection / herniation of the contents of the eye, effectively releases pressure when the pressure in the flexible eye cover is increased due to bleeding and edema of tissues with the development of the injury, avoids ischemic necrosis of eye tissues and orbital apex syndrome caused by excessively high pressure or excessively tight bandaging, and discriminates the severity of the injury, thereby being convenient for subsequent treatment.

Certain aspects of the present disclosure provide systems and methods for measuring ocular tissue biomechanics via blink stimulation. In some embodiments, a method may be performed by a computer in communication with an optical coherence tomography (OCT) device. The method includes monitoring movement relative to an eye of a patient via one or more images from a camera. The method also includes detecting a blink of the eye of the patient in response to the monitoring. The method further includes, in response to the detected blink, recording data resulting from a scan of at least a portion of the tissue of the eye by the OCT device. The method further includes measuring a response of the tissue to the detected blink based on the recorded data from the scan.

Disclosed are devices and methods for directed delivery of a medicament into ocular tissue. A device for delivering a medicament to ocular tissue may include a housing, a container configured to contain the medicament, and a needle in fluid communication with the container, and a carriage positioned within the housing and coupled to the container and the needle. The carriage may be translatable along the needle axis and the carriage may include a threaded outer surface. The device may further include a nut positioned within the housing and engaged with the threaded outer surface. Rotation of the nut may be configured to cause the carriage and the needle to translate in a distal direction along the needle axis.

The invention discloses an intelligent implantable glasses system based on a brain-computer interface and optical imaging, relates to the technical field of nerve regulation and control, and solves the problem of poor adaptability of a rigid substrate by adopting a specific flexible substrate and a multi-layer coating structure through a flexible implantation carrier module to adapt to eyeballs or periorbital tissues; the multi-modal sensing decoding module integrates multiple types of sensors and a fusion algorithm, so that multi-dimensional signal capture and cooperative decoding are realized, and the limitation of single-modal signal decoding is overcome; the closed-loop control function module constructs a closed-loop regulation and control link, dynamically adjusts parameters according to the physiological state of a user, and changes a traditional open-loop control mode; the wireless energy supply encryption module is integrated with a wireless energy supply and encryption communication assembly, stable energy transmission and signal security encryption are achieved, and the problems of separation of wireless communication and an energy supply module and potential data safety hazards are solved. And the external terminal interaction module is linked with the implantation side module through a wireless link to realize cooperative work.

Device (2) for an ophthalmic illumination system (1) comprising a light instrument (3) for illuminating the intraocular space of a human or animal eye (33), wherein the device (2) comprises a housing (4) with a proximal housing end (5), a distal housing end (6), and an opening (7) in the proximal housing end (5), wherein the housing (4) defines a receiving space (8) which extends from the opening (7) in the proximal housing end (5) along a longitudinal direction (L) towards the distal housing end (6), and wherein the receiving space (8) for receiving the light instrument (3) is formed through the opening (7) in the proximal housing end (5), wherein the housing (4) comprises at least one translucent material at least in the region (10) of the distal housing end (6), wherein the device (2) is designed for indentation of the ocular tissue (34), in particular the sclera (9), wherein the distal housing end (6) with respect to a central longitudinal axis (A) of the housing (4) defines an opening angle (α) for emerging light of the light instrument (3) of approximately 110° according to EN-ISO 15752:2010, and wherein the distal housing end (6) is substantially dome-shaped or has the form of a sphere that is substantially flattened at least on one side, and / or wherein the housing (4) defines a canonical solid angle (β) in the region of the distal housing end (6) which is 2·π steradians, wherein this solid angle (β) forms a lateral surface of a right circular cone with a half, planar opening angle (α) of 90 degrees, such that within this solid angle (β) the radiance of the light (38) emerging from the region of the distal housing end (6) of the light instrument (3) is at least 60% of the radiance of the light (38) of the light instrument (3) within this solid angle (β).

A method comprises treating an ocular condition resulting from an MMP imbalance comprising: applying to the ocular tissue an effective amount of a therapeutic composition, wherein said therapeutic composition comprises a first MMP inhibitor comprising EDTA.

An ophthalmological device comprises a laser source, an application head having focusing optics and a patient interface, a scanner system and circuit. The circuit is configured to control the scanner system to incise an incision surface, which is symmetrical with respect to the central axis of the patient interface, in the eye tissue, a pulsed laser beam being steered onto treatment points on the incision surface on a first treatment path, and the treatment path being curved while extending around the projection axis of the focusing optics. In the event of a tilt of the eye with respect to the central axis of the patient interface, the circuit determines an apex of a tilted incision surface by a co-tilt of the incision surface corresponding to the tilt of the eye, and determines a transformed treatment path, which extends around the apex and determines treatment points on the tilted incision surface.

The application relates to an intelligent ophthalmic ultrasonic emulsifier and a use method, and belongs to the technical field of ophthalmic surgical instruments, which comprises a main machine body, an operating handle, an anchor component and a viscosity type self-locking mechanism, an ultrasonic amplitude rod, a perfusion pipeline and a suction pipeline are arranged in the operating handle, an emulsification needle head and a perfusion sleeve are arranged at one end of the operating handle, a liquid inlet chamber is formed between the emulsification needle head and the perfusion sleeve, the anchor component is arranged in the liquid inlet chamber and is used for anchoring a hard nucleus in front of an opening of the emulsification needle head, and the viscosity type self-locking mechanism is arranged in the suction pipeline and comprises a hairspring disc body provided with a plurality of micropores; the hairspring disc body is configured to be deformed to block the suction pipeline when a high-viscosity fluid cannot pass through the micropores; the hard nucleus is anchored by the anchor component, so that the ocular tissue is prevented from being damaged by the rebound of the nucleus block; meanwhile, the viscosity type self-locking mechanism is used for instantaneously blocking the suction pipeline when the vitreous body is sucked, so that the retina is prevented from being damaged by traction, and the surgical safety and efficiency are improved.

A method of refraction-correcting ophthalmic surgery in tissue of an eye after at least one previous ophthalmic surgery in the tissue, comprising accessing information on a pre-operative cut and defining a cut surface on the basis of the information on the pre-operative cut of the at least one previous ophthalmic surgery of the tissue of the eye.

Certain aspects of the present disclosure provide systems (10) and methods (800) for real-time measurement of biomechanics at a plurality of ocular tissue locations. In some embodiments, the method (800) may be performed by a computer (30) in communication with an optical coherence tomography (OCT) device (15, 315). The method includes receiving an indication that stimulation is applied to ocular tissue (346) of a patient (42). The method further includes instructing the OCT device (15, 315) to emit a plurality of light beams (344, 560, 660) to a plurality of measurement locations (772) on the ocular tissue (346) at substantially the same time in response to the received indication. The method (800) also includes receiving OCT data for each of the plurality of measurement locations (772) from the OCT device (15, 315). The method (800) also includes measuring a tissue response to the stimulation at the plurality of measurement locations based on the OCT data.

The application provides an eye preparation for preventing and treating cataract by eye drop, which is composed of an active substance for treating eye diseases and a pharmaceutically acceptable carrier or excipient; the active substance for treating eye diseases is oxidized cholestanol, including lanosterol or 25-hydroxycholestanol; the pharmaceutically acceptable carrier or excipient contains a surfactant, a tackifier, a cosolvent and a solvent; the content of the oxidized cholestanol in the preparation is 0.01-5 mg / mL; the mass ratio of the surfactant, the tackifier, the cosolvent and the oxidized cholestanol is (1-300):(1-100):(100-3000):1, and the rest is the solvent. After the eye drop of the preparation, the active substance can be selectively enriched in the lens of experimental animals, so that the effect of treating cataract can be accurately exerted, and the active substance is not distributed in the aqueous humor and the vitreous body, thereby avoiding the toxic and side effects on other eye tissues and the whole body. The application solves the technical problem which people in the field of ophthalmic drug delivery have been eager to solve but have failed to obtain success, and has a very high clinical application value and social value.