104 results about "Ischemic necrosis" patented technology

A method of treating avascular necrosis (“AVN”) comprising administering one or more osteoinductive formulations to the site of AVN disease progression. The method involves the combination of a core decompression technique, followed by the introduction of one or more osteoinductive formulations into the decompression core, and concluding with capping of the lateral aspect of the decompression core with a femoral core cap. The osteoinductive formulations of the invention comprise one or more osteoinductive agents and suitable carrier molecules. The femoral core cap retains the osteoinductive formulation within the decompression core, thereby preventing leakage of the osteoinductive formulation from the decompression core. The method of the invention optionally comprises introduction of autograft or allograft with the osteoinductive formulations of the invention. The method of the invention further optionally comprises incorporation of sustained release compositions to provide extended periods of osteogenesis.

The present invention provides a pharmaceutical composition and a method for reducing an infarct region resulting from the ischemic necrosis of cells, especially, a pharmaceutical composition and a method for suppressing ischemia-reperfusion injury in the treatment of ischemic heart disease. The pharmaceutical composition and the method utilize a substance, as an active ingredient, which can increase intracellular cGMP production by acting on a natriuretic peptide receptor, and which has the effect of reducing an infarct region. The substance is preferably a natriuretic peptide. The present invention is particularly useful for the treatment or prophylaxis of ischemic disease.

The invention relates to medicinal liquor for treating bone disease, which comprises the following substances by weight: 50 parts of Panax japonicum, 50 parts of tuber santsigu, 50 parts of ground beetle, 50 parts of safflower, 15 parts of Paris polyphylla, 15 parts of rhizoma drynariae, 18 parts of pseudo-ginseng, 30 parts of Sanguis Draconis, 50 parts of radix clematidis, 20 parts of myrrh, 50 parts of gardenia jasminoides, 12 parts of dried orange peel, 30 parts of cortex eucommiae, 30 parts of chaff flower root, 30 parts of pawpaw, 30 parts of buck grass, 30 parts of cassia twig, 50 partsof fiveleaf akebia, 24 parts of coralbean bark and 24 parts of common dodder. The present invention also relates to a method for preparing the medicinal liquor. The medicinal liquor provided by the invention can be used for treating rheumatic numbness of limbs, rheumatic arthritis, cervical spondylosis, periarthritis humeroscapularis, ischialgia caused by lumbar muscle strain, hyperosteogeny, hernia of intervertebral disc, spondylosis and ischemic necrosis of femoral head, traumatic injury, bone fracture, soft tissue contusion sequelae and the like.

The invention discloses a medicinal composition for treating rheumatism. The medicinal composition is prepared from the following Chinese medicinal herbs serving as raw materials in parts by weight: 3-18 parts of wild ginger, 3-24 parts of dahurian angelica root, 3-18 parts of Chinese angelica, 6-36 parts of safflower, 3-18 parts of astragalus, 3-18 parts of barbary wolfberry fruit, 6-36 parts of honeysuckle flower, 3-18 parts of white paeony root, 3-18 parts of kudzuvine root, 2-8 parts of dried ginger and the like. The medicinal composition has good curative effects on various rheumatisms such as migratory arthralgia, arthritis, arthritis, obstinate arlhralgia and like, and has good curative effects on other similar relevant rheumatisms such as knee osteoarthritis, lumbar vertebra hyperosteogeny, knee osteoarthritis, gouty arthritis, ischemic necrosis of femoral head, women rheumatism (general aching during menstruation, pantalgia after childbirth and puerperal arthralgia), lupus sebaceous, psoriasis, sicca syndrome, and the like.

The invention belongs to the technical field of biomedicine materials, and particularly relates to a bone repair scaffold and a preparation method thereof. The bone repair scaffold is of a porous structure of the size matched with the size of a bone defect part of a patient. The preparation method of the bone repair scaffold comprises the steps that firstly, a design entity of the scaffold is built through three-dimensional design software; secondly, a three-dimensional model of a construction unit of a porous matrix structure is constructed; thirdly, the design entity is filled with the construction unit of the three-dimensional model through the three-dimensional design software, and the design entity is manufactured into the porous matrix structure; fourthly, the porous matrix structureis printed through a 3D printer, and a printed piece is obtained. The scaffold can be used for repairing bone defects, the osteogenesis and angiogenesis capacity can be improved, the scaffold can beimplanted into a large-segment bone defect or a cavity formed after the lesions of early femoral head ischemic necrosis are removed, and a biomechanical supporting effect and the effect of promoting the ingrowth of blood vessels and bone tissue are achieved.

The invention discloses a Chinese medicament bone-knitting pill preparation, which is prepared from peach kernel, safflower, ligusticus wallichii franchet, frankincense, myrrh, corydalis, achyranthes, ground beetle, dragon blood, leech, earthworm, Chinese angelica, cooked rehmannia, pyrite, eucommia, dipsacus, drynaria, gardenia, plantago seed, lycium bark, acanthopanax, bitter orange, parsnip, angelica, dioscorea, poria, cinnamon bark, red ginseng and other precious traditional Chinese medicaments according to certain proportion; the Chinese medicament bone-knitting pellet preparation can be used for treating femoral head necrosis, in particular ischemic necrosis of femoral head and other diseases, can effectively treat the femoral head necrosis and bone fracture in clinical treatment and has the advantages of good treatment effect and no side effect.

The present disclosure provides a support element (10,110) for use in effecting ischemic necrosis in a foreskin (186) of a penis, being a closed-loop member defining an opening (12) dimensioned to permit a penis glans to pass therethrough and having an inner surface (14) and an outer surface (16); the outer surface comprising a circumferential support (18, 118) for an elastic ring (150) to be mounted thereon, said circumferential support being formed within a groove (20,120) in at least part of the outer surface; at least one first segment (26, 28) of the outer surface having an outer curvature of a radius larger than that of its flanking second segments (30, 32). Also provided herein is a system (100) for effecting ischemic necrosis in a foreskin (186) of a penis, comprising the support element (110) and elastic ring (150), and optionally a deployment element (160) for mounting the elastic ring over the foreskin and support element.

The invention discloses a urethra catheter for expansion of a urethral canal and a manufacturing method thereof. The manufacturing method comprises the following steps of; (1) preparing a urethra catheter; (2) preparing a positioning device; and (3) preparing an expansion device. The invention also discloses a produced manufactured in the above method. The method is simple and can be realized easily, and the cost is low. The urethra catheter has a delicate design and reasonable structure. After the urethra catheter inserted into the urethral canal, the positioning device and the expansion device in a narrow state can be tightly attached to the outer wall of the urethra catheter, the outside diameter of the urethra catheter can be reduced effectively, and pains of patients can be eased; the urethra catheter can be effectively positioned in the bladder by the positioning device to facilitate positioning and expansion operations of the expansion device for a part to be expanded, an intermittent inflation or liquid filling method is adopted during expansion, the urethral canal can be expanded, urethral stricture can be treated, mucosal ischemic necrosis can be avoided, the surgical safety and effectiveness can be improved greatly, and the large-scale promotion and application can be facilitated.

The invention discloses a method for researching the effects of Dickkopf-1 and cell apoptosis in steroid-induced avascular necrosis of femoral head (SANFH). The method comprises the following steps: by taking the femoral head sample of SANFH taken through total hip replacement as an experiment group and taking the sample after the hip replacement for fracture of neck of femur as a contrast group, cutting the femoral head sample, fixing and decalcifying the cut femoral head sample to prepare slices, observing the morphologic change of osteocytes by an electronic microscope, observing the pathological change of the osteocytes by a light microscope, counting the vacant bone lacuna, detecting the expression of Dickkopf-1 by an immunohistochemical staining technique, thus exploring the effects of Dickkopf-1 and cell apoptosis in SANFH. The method can be used for providing assistance for early diagnosis and curing of SANFH and also providing a theoretical basis for clinical prevention and curing of SANFH in future.

A Chinese medicine for treating femur head necrosis is prepared from 19 Chinese- medicinal materials including notoginseng, wolfberry fruit, red sage root, Chinese angelica root, etc. Its preparing process is also disclosed.

The invention relates to a medical appliance, in particular to a pressurized hollow nail, which comprises a hollow nail body, wherein a self-tapping blade head is arranged at an initial end of the nail body; the outer surface of an initial section and the outer surface of an end section of the nail body are both provided with threads; the thread pitch of the threads arranged on the outer surface of the end section is less than that of the threads arranged on the outer surface of the initial section; and the side wall of an intermediate section of the nail body is provided with a plurality of through holes. In the process of treating femur neck fracture with the hollow nail, as the hollow nail is provided with a plurality of through holes at both ends of a fracture line respectively, blood in spongy bones at a far end of the fracture line can be driven to enter into the hollow nail body through the through holes and flow out from through holes at a near end of the fracture line, and to be sent into a femoral head at the near end of the fracture line, thereby the blood exchange and circulation between two ends of a fracture section are realized and greatly accelerated. Moreover, the blood supply of corresponding femoral heads can be increased, and the fracture healing is promoted, thus the ischemic necrosis of the femoral heads is avoided. Therefore, the pressurized hollow nail is of great significance in the prevention of the ischemic necrosis of the femoral heads caused by the femur neck fracture.

The invention relates to a fiber porous titanium rod for repair of ischemic necrosis of femoral head. The fiber porous titanium rod comprises a fiber porous titanium rod body and a nanometer strontium apatite layer coated on the outer surface of the fiber porous titanium rod body. Diameter of the fiber porous titanium rod body is 1-2cm, height of the rod is 50-80cm, pore diameter distribution is 100-800mum, porosity is 80.0+-2.0%, and pores are communicated with each other. The fiber porous titanium rod is implanted in the femoral head with the ischemic necrosis, can replace a defect area to have strong supporting effect, can promote adhesion, multiplication and differentiation of bone cells on the basis of maintenance of characteristics of an original fiber porous material, effectively induces formation of bones, and enhances osseointegration and bone bonding.

The present invention discloses a Chinese medicine composition. Said medicine composition includes 11 Chinese medicinal materials of carthamus flower, wingless cockroach, nux vomica, prepared myrrh, notoginseng, borneol, calcined pyrite and others. Said medicine composition can be used for effectively curing the diseases of traumatic injury, sudden sprain in the lumbar region, pain in the chest when breathing, injury of the muscle and tendon, swelling pain and ischemic necrosis of femoral head, etc. Besides, said invention also provides its preparation process and concrete steps.

The invention discloses a detection method of adenovirus-mediated gene transfection autologous bone marrow mesenchymal stem cells. The detection method includes: using hBMP-2 genes to transfect bone marrow mesenchymal stem cells BMSCs by the aid of a recombinant defective adenovirus expression carrier Ad-hBMP-2, compositing the transfected cells with a allogeneic decalcified bone DBM stent material in an in-vitro manner, implanting into an ANFH animal model, and performing X-ray detection, transmission electron microscope detection, histological detection, immunohistochemical analysis (semiquantitative) and mechanical performance detection on the repaired femoral head. By the detection method, the conditions and influence factors of the proliferation, directional differentiation and degeneration of the stem cells are illustrated, cytology theoretical support is provided for methods using the stem cells to treat ANFH, and basis and support are provided for the clinical application of the methods using the stem cells to treat the ischemic necrosis of the femoral head by successfully demonstrating the relation between the number, differentiation, degeneration and the like of the bone marrow mesenchymal stem cells and the ischemic necrosis of the femoral head.

The invention discloses a medicinal paste for treating ischemic necrosis in head of femur. The medicinal paste is characterized in that: the medicinal paste is prepared from the following raw material medicaments in part by weight: 25 to 35 parts of pigeon pea leaf, 10 to 13 parts of root of red-rooted salvia, 15 to 20 parts of szechuan lovage rhizome, 13 to 20 parts of rotating Jerusalem sage, 10 to 14 parts of prepared frankincense, 15 to 20 parts of prepared myrrh, 5 to 10 parts of dragon's blood, 15 to 20 parts of Chinese starjasmine stem, 16 to 20 parts of medicinal cyathula root, 15 to 20 parts of glabrous sarcandra herb, 16 to 20 parts of cassia twig, 15 to 21 parts of clematis root, 15 to 20 parts of fortune's drynaria rhizome, 10 to 15 parts of rehmanniae vaporata, 10 to 15 parts of eucommia bark, 20 to 25 parts of borneol and 5 to 10 parts of mask. The medicinal paste has the effects of promoting blood circulation and removing blood stasis, promoting qi circulation and removing obstruction in the collaterals, relieving swelling and easing pain, removing the rotten to let fresh grow and tonifying kidney and growing bone, and has the advantages of good curative effect, quick response, no toxic or side effect, readily available materials, low cost and convenient preparation.

The invention discloses a Chinese herbal medicine preparation used for treating avascular necrosis of femoral head. The preparation is prepared from 10-15 parts of ligusticum, 3-9 parts of incised notopterygium rhizome and root, 10-25 parts of dragon's blood, 2-3 parts of common monkshood mother-root, 6-10 parts of Chinese quince, 6-12 parts of angelica dahurica, 5-10 parts of weeping forsythia fruit, 5-10 parts of fourstamen stephania root, 3-6 parts of safflower, 5-10 parts of drynaria, 6-10 parts of radix dipsaci, 3-5 parts of bamboo-living shiraia stroma, 2-3 parts of catechu, 4-8 parts of native copper, 2-6 parts of myrrh, 5-10 parts of frankincense, 3-6 parts of achyranthes bidentata, 5-10 parts of Chinese ephedra herb, 2-3 parts of kusnezoff monkshood mother-root, 5-10 parts of cucumber seed, 3-6 parts of rheum, 2-4 parts of saposhnikovia divaricata, 1-3 parts of borneol, 6-12 parts of lumbricus, 2-4 parts of heterophyllous wingseedtree root or stem, 2-4 parts of justicia procumbens, 4-6 parts of giantleaf ardisia rhizome, and 3-9 parts of gynura rhizome. The Chinese herbal medicines are decocted into a thick solution. The solution is filtered, recovered, bottled, sterilized, and preserved for later use. The Chinese herbal medicine preparation provided by the invention is advantaged in simple production technology, easy operation, convenient application, safe administration, and no toxic or side-effect.

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine for treating ischemic necrosis of femoral head. The traditional Chinese medicine for treating ischemic necrosis of femoral head is prepared from the following raw materials: cornu cervi, herba cistanche, resina draconis, frankincense, myrrh, salviae miltiorrhizae, flowers carthami, radix achyranthis bidentatae, eucommia ulmoides, woodwardia japonica, drynaria rhizome, schisandra chinensis, astragalus membranaceus, Chinese yam, angelica sinensis, radix rehmanniae preparata, costustoot, poria cocos, loranthus parasiticus, liquorice, notopterygium, radix clematidis, buddleja asiatica, ligularia japonica, cuneate lespedeza herb with root, common calanthe herb and herba inulae. According to the traditional Chinese medicine, the adopted medicinal materials are in supplement with each other; the traditional Chinese medicine is prepared by the theoretical composition of the traditional Chinese medicine according to a certain weight ratio, has a significant curative effect on treatment of ischemic necrosis of femoral head, and is abundant in raw material source, moderate in price, simple in process and easy to accept by patients; the pain of aches and limitation of motion of patients can be relieved or even avoided; the diseases are treated; the constitution of patients can be enhanced; and health is promoted.

The present invention discloses a Chinese medicine composition. Said Chinese medicine composition is a preparation made up by using 9 Chinese medicinal materials of frankincense, myrrh, Chinese angelica root, wingless cockroach, borax, calcined pyrite and others as raw material through a certain preparation process. Said Chinese medicine composition can obtain obvious therapeutic effect for curing traumatic injury, pain caused by blood stasis and ischemic necrosis of femoral head. Said invention also provides preparation method of said medicine composition and its quality control method.

The invention relates to degradable gel microspheres interposed in a bronchus and application thereof. The degradable gel microspheres comprise hyaluronic acid-calcium alginate gel microspheres and medicament-loaded chitosan-calcium alginate gel microspheres, wherein the hyaluronic acid-calcium alginate gel microspheres and the medicament-loaded chitosan-calcium alginate gel microspheres are mixed together uniformly according to proportion, and the volume ratio is 2:1-9. The degradable gel microspheres can be used for preparing sustained-release and controlled-release medicaments for treatinglung cancer, lung tumor, tuberculosis, pneumonia and bronchitis and a tissue engineering scaffold material. The degradable gel microspheres interposed in the bronchus do not block up a lung bronchus and also do not initiate ischemic necrosis of surrounding tissues of the bronchus, so the degradable gel microspheres can be used as the tissue engineering scaffold material and a medicament sustained-release scaffold. Two types of microspheres with different functions have complementary advantages, overcome the technical difficulties of microsphere blockage and pulmonary ventilation in the bronchus, and can significantly reduce toxic or side effect of medicaments and improve therapeutic indexes of the medicaments.

A Chinese medicine for treating bone injury and ischemic necrosis of femur head is prepared from fortune's drynaria rhizome, cajan leaf, glabrous sarcandra herb and medicinal additive. Its preparing process is also disclosed.

The invention discloses a femoral head necrosis staging analysis method and system based on artificial intelligence, and the method achieves the binary classification analysis of femoral head ischemic necrosis through the positioning and recognition of a hip joint MRI image and the automatic segmentation of a hip joint bone model, and further carries out the classification analysis of the femoral head necrosis staging. The system comprises an image acquisition module, an image segmentation module, a positioning analysis module, a lesion staging module and a report generation module. The MRI image is fully utilized, lesion features are intelligently recognized, the femoral head necrosis detection rate and the staging accuracy are improved, and an efficient, rapid and accurate femoral head necrosis staging analysis system can be constructed.

The invention discloses a medicament for treating femoral head ischemic necrosis, which comprises the constituents of (by weight percent) tortoise shell30-60, dragon's blood resin 40-60, antler gelatin 40-60, pangolin scales 40-60, rhizome of Sichuan lovage 40-60, Chinese angelica root 40-60, safflower 40-60, prepared rehmannia root 40-60, the traditional Chinese medicinal preparation is synthesized through screening, purification, sterilization, drying and disintegration.

A Chinese medicine for treating the ischemic necrosis of femur head is prepared from cajan leaf, glabrous sarcandra herb and medicinal additive. Its preparing process is also disclosed.

The invention provides a medicament for treating femoral head necrosis. The medicament is prepared from the following traditional Chinese medicinal materials in parts by weight: 40-50 parts of pseudo-ginseng, 75-90 parts of suberect spatholobus stem, 75-90 parts of radix achyranthis bidentatae, 75-90 parts of medlar, 75-90 parts of teasel root, 75-90 parts of rhizoma drynariae (sand heated), 75-90 parts of salviae miltiorrhizae, 75-90 parts of Chinese angelica, 75-90 parts of ligusticum wallichii, 75-90 parts of cortex acanthopanacis, 115-130 parts of prepared rehmannia root, 115-130 parts of codonopsis pilosula, 75-90 parts of rhizoma atractylodis macrocephalae, 115-130 parts of prepared frankincense, 115-130 parts of prepared myrrh, 115-130 parts of corydalis tuber, 20-25 parts of rheum officinale, 75-90 parts of radix curcumae and 75-90 parts of costusroot. The medicament can be used for improving the testosterone of a rat caused by hydrocortisone, reducing T3 and T4, increasing the relative volume and average bone trabecula width, improving resistance of a kidney-deficiency mouse, improving relative bone volume reduction and average bone trabecula width reduction caused by tretinoin, improving contents of bone calcium and phosphor, improving microcirculation disturbance, diminishing swelling and relieving pain and improving immunity, and has a good curative effect in the aspect of treating femoral head necrosis.