76 results about "Bone bonding" patented technology

In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and / or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.

Featured are a biocompatible, injectable, self-setting, cohesive, bone-bonding and remodeling calcium phosphate composite material and its use in methods of repairing defective bone, e.g., in vertebroplasty augmentation and kyphoplasty.

The invention provides a prosthesis component and a method for manufacturing the same. The prosthesis component comprises a bone bonding layer (10), a ceramic layer (20) and a buffer layer (30). The ceramic layer (20) is arranged above the bone bonding layer (10), and the buffer layer (30) is arranged between the bone bonding layer (10) and the ceramic layer (20). According to the technical scheme, the prosthesis component and the method have the advantage that the problem that a prosthesis component in the prior art is easy to loosen after being implanted into a patient can be effectively solved by the aid of the prosthesis component and the method.

The invention provides a bioactive glass ceramic fiber-PEEK resin composite artificial tooth and a preparation method. The preparation method of the artificial tooth comprises the four steps of preparing hydroxy calcium phosphate crystal glass ceramic fragments, preparing bioactive glass ceramic fibers, preparing the bioactive glass ceramic fiber-PEEK resin composite artificial tooth and conducting surface layer treatment on the portion, implanted into the alveolar bone, of the artificial tooth. The bioactive glass ceramic fiber-PEEK resin composite artificial tooth product prepared according to the method not only has the enough mechanical property, but also has the very good biocompatibility, and the mechanical property, the biocompatibility and the bone bonding strength are all greatly superior to those of a conventional artificial tooth product; in addition, the whole preparation technology process is simple, operation is convenient, and therefore the artificial tooth is very worthy of energetical popularization.

The invention relates to a gradient composite material and a preparation method and an application thereof. The method comprises the steps: preparing a variety of slurries with different contents of bioactive ceramic powder from a biocompatible polymer and the bioactive ceramic powder with an organic solvent; and carrying out layer-by-layer tap casting or layering tap casting co-pressing of a variety of slurries in a manner of progressively increasing or decreasing the contents of the bioactive ceramic powder, to prepare the gradient composite material containing a plurality of layers of tap-casted films. The gradient composite material preferably contains four layers of tape-casted films, and the volume percentage contents of the bioactive ceramic powder are 0%, 30%, 50% and 70% from thefirst-layer tape-casted film to the fourth-layer tape-casted film respectively. The prepared gradient composite material can promote the early adhesion and proliferation of osteoblasts and fibroblastsand effectively promote the formation of transition layers between tendons and bone tissues, and the tendon-bone bonding strength can be increased by 38.6%. The gradient composite material provided by the invention can be used as a tendon-bone healing patch material, and is a quite potential biomedical material.

The invention provides a GF / PEEK composite artificial tooth with a novel BGC coating and a preparation method of the artificial tooth. A blank of the artificial tooth is prepared from a GF / PEEK composite; the elastic modulus and an expansion coefficient of the composite are close to those of a human bone; the toughness and the fatigue reliability of the composite are good; the blank and the novel BGC coating sprayed on the surface of an implantation part have higher cohesion and close expansion coefficients, and are securely combined. Therefore, compared with the conventional titanium artificial tooth, the mechanical property, the biocompatibility and the bone bonding strength of the artificial tooth are better; the coating cannot easily fall. The novel BGC coating is sprayed on the surface of the implantation part of the artificial tooth, and a micro / nano porous groove structure and an exposed nano hydroxyapatite particle rough surface are presented, so that cell adhesion can be facilitated; early repair of the bone is accelerated. The artificial tooth is low in material price, simple in preparation technology, easy to produce, cheap and fine, and is worthy of popularization.

The invention discloses a biodegradable and medical tricalcium phosphate / gamma-polyglutamic acid composite and a preparation method thereof. According to the invention, an in situ complexing method is adopted for preparing the biodegradable and medical tricalcium phosphate / gamma-polyglutamic acid composite, the composite is formed by complexing tricalcium phosphate and gamma-polyglutamic acid by virtue of intermolecular group carboxylate radicals, tricalcium phosphate powder is deposited on a gamma-polyglutamic acid substrate, mechanical strength of the composite is enhanced under the action of a crosslinking agent, toughness of tricalcium phosphate is improved, and bone bonding ability and degradability of the tricalcium phosphate are improved, so that repair of bone defect can be promoted. Pore size of the composite is 60-280Mum, porosity range is 64-85%, weight loss ratio is 8.60-39.57% after the composite is soaked in 0.9% normal saline and stands still for three months at constant temperature of 37 DEG C, the composite has the characteristics that the tricalcium phosphate is uniformly distributed, the tricalcium phosphate and the gamma-polyglutamic acid are tightly combined and degradation rate is continuous and adjustable, the pore size of the composite is appropriate, and the composite can be taken as bone repair material to be applied to the biomedical fields such as bone tissue engineering.

The invention discloses a preparation method for a bioactive ceramic membrane on the surface of a tantalum metal, for solving the problem that the tantalum metal cannot generate bone bonding with bone tissues after being implanted in a body due to poor activity and bone induction capacity, and the problems that the prior art is complicated in process and high in cost and bonding strength of an obtained membrane layer and a matrix is weak. The preparation method comprises the following steps: 1, treating the surface of the tantalum metal; 2, preparing electrolyte; 3, with the tantalum metal as an anode and stainless steel as a cathode, setting an electrical parameter and carrying out micro-arc oxidation; and 4, carrying out hydrothermal treatment in a hydrothermal autoclave to obtain the bioactive ceramic membrane. With the adoption of the preparation method, process is simple; the used electrolyte is non-toxic, non-pollution and environmentally friendly, a calcium tantalite-containing coating with high biological activity and binding force is directly prepared on the tantalum metal by virtue of micro-arc oxidation and hydrothermal treatment, and the biological activity of the tantalum metal is well improved.

The invention provides a novel gamma-polyglutamic acid / hydroxyapatite composite material and a preparation method thereof. The method comprises the following steps of: preparing calcium ion and phosphorous ion solutions; adding a gamma-polyglutamic acid solution into the calcium ion solution to react; dropwise adding the phosphorous ion solution; and preparing the composite material by virtue of stirring, aging, compression molding and lyophilizing. The invention is a novel method of preparing the novel gamma-polyglutamic acid / hydroxyapatite composite material by adding gamma-polyglutamic acid into hydroxyapatite by virtue of an in-situ polymerization method. The novel gamma-polyglutamic acid / hydroxyapatite composite material prepared by the method of the invention is transparent oyster white with bending strength of 135.0MPa and remarkably improved mechanical performance. The composite can guarantee that: calcium ions and phosphorus ions in the hydroxyapatite in a bone repairing process are released from the gamma-polyglutamic acid constantly, smoothly and slowly, the bone bonding capability of the hydroxyapatite composite material can be improved, and bone defect repairing is promoted.

The invention belongs to the technical field of implants and particularly relates to a treatment process for improving the surface hydrophilicity of an implant. The method comprises the following steps: firstly carrying out sand blasting and acid etching treatment on an implant, then carrying out alkali heat treatment and plasma oxidation treatment to enable secondary pits in the surface of the implant to be more uniform and compact, finally directly immersing the implant subjected to the plasma oxidation treatment into a mixed solution of MgCl2, CaCl2 and NaCl with an adjusted pH value, and carrying out hydrophilic treatment to obtain the implant with better hydrophilicity. The surface of the implant prepared by the method not only can improve the mechanical gomphosis of the implant and surrounding bone tissues, promote the adsorption effect of bioactive molecules and cells, facilitate the adhesion and proliferation of the cells, but also improve the surface energy and the wettabilityof the cells, accelerate the initial bone bonding speed of the implant and achieve rapid bone integration. The process is simple and suitable for commercial production.

In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and / or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.

The invention provides a novel strontium-doped gamma-polyglutamic acid / tricalcium phosphate composite material and a preparation method thereof. The method comprises the steps of preparing calcium ion, phosphonium ion and strontium ion solutions, adding gamma-polyglutamic acid to the calcium ion and strontium ion solutions for reacting at first, and then dropwise adding the phosphonium ion solution, and carrying out stirring, ageing, setting and freeze-drying to obtain the composite material. The preparation method is a new method of adding the biopolymer gamma-polyglutamic acid and the strontium element to tricalcium phosphate to prepare the strontium-doped gamma-polyglutamic acid / tricalcium phosphate composite material through an in-situ polymerization wet process. The strontium-doped gamma-polyglutamic acid / tricalcium phosphate composite nano-material prepared by the method is a white powder; the compressive strength of the composite material ranges from 71Mpa to 105Mpa and the bending strength of the composite material ranges from 65 to 98Mpa, and the mechanical properties of the composite material are obviously improved. The composite material is capable of ensuring that calcium ions and phosphonium ions in tricalcium phosphate and strontium ions are released from the gamma-polyglutamic acid continuously, steadily and slowly in the bone repair process, and is also capable of improving the bone bonding ability of the tricalcium phosphate composite material and promoting repair of bone defect.

In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and / or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics.

An implant includes a tool receiver for coupling to an implantation tool and also a connecting device for connecting the implant to an injection cannula for the purposes of injecting a bone bonding material in such a manner that the handling and production thereof are simplified. The connecting device may include an internally threaded section which is formed in or on the tool receiver. An implantation system includes at least one injection cannula and at least one implant.

The invention discloses a preparation method of a biological piezoelectric coating on the surface of a titanium-based material. The preparation method specifically comprises the following steps: preparing a titanium dioxide nanotube coating on the surface of the titanium-based material by adopting an anodic oxidation method, and carrying out ultrasonic treatment by using hydrochloric acid; then adding the product into an alkaline hydrothermal solution for hydrothermal reaction; and finally, cleaning and drying to form the biological piezoelectric coating on the surface of the titanium-based material. According to the method, the biological piezoelectric coating is formed on the surface of the titanium alloy, the biological piezoelectric coating has a nano structure, and a piezoelectric nanotube grows on the surface of the titanium-based material in situ and has good combination and nano effects with a matrix; meanwhile, the nanotube has a specific in-tube structure, has unique advantages in the aspects of medicine carrying and long-acting slow release, is beneficial to further treatment of bone injury parts, and accelerates the bone repair process. The piezoelectric property and the nano structure of the coating can promote the implant and nearby tissues to form effective bony combination, and the occurrence risk of looseness and complications is reduced.

The invention provides a high-toughness super-wear-resistance artificial bone for repairing bone defects. The artificial bone has a structure of inner and outer layers, wherein the inner layer is an artificial bone rack made of PEEK resin, and is compounded with barium glass fibers and calcium carbonate whiskers; the outer layer the outer layer of the artificial bone rack is coated with a hardened compact layer which is sintered by bio-active glass ceramics; and a porous layer formed by bioactive glass ceramics is attached to the surface of the compact layer. The bonding performing of bioactive glass ceramics with bone is higher than that of hydroxyapatite, and the bonding performance of PEEK resin with bioactive glass ceramics is better than that of carbon fibers with hydroxyapatite, so that the artificial bone has enough mechanical performance and good biocompatibility, and has the mechanical performance, biocompatibility and bone bonding strength is superior than those of a conventional artificial bone product.

The invention discloses a double-acid treatment device applied to surface of dental implant and a preparation method. The double-acid treatment device comprises a rack, a liquid storage tank and a lifting mechanism are arranged in the rack, the lifting mechanism is fixedly connected with a supporting rod, and the other end of the supporting rod is connected to the center of a dental implant fixingdisc; a driving motor is mounted between the center of the dental implant fixing disc and the supporting rod; a circle of dental implant fixing holes are evenly formed in the other end face of the dental implant fixing disc, dental implant fixing frames are installed in the dental implant fixing holes, and rotating motors are arranged at the lower ends of the dental implant fixing frames; and a dental implant is sleeved at the upper end of the dental implant fixing frame. Through the structural design of the double-acid treatment device, after the dental implant is subjected to sand blastingby adopting titanium dioxide particles, pits with three-stage holes are formed through double acid etching treatment, so that the stability and the bone bonding rate of the dental implant at the initial implantation stage are increased, new bone formation is promoted, and the healing time is shortened; therefore, the ideal effects of immediate planting and immediate load recovery are achieved.

The invention relates to a surface treatment process of a dental implant and an application thereof, and belongs to the technical field of dental implanting. The surface treatment process of the dental implant includes the steps of carrying out acid etching treatment of an implant treated by rutile sand blasting and carrying out alkali treatment of the implant subjected to acid etching treatment.Sand blasting treatment on the surface of the implant with rutile sand makes the surface of the pure titanium implant free from interference of other impurity elements, and first-order holes can be effectively formed by large-particle sand blasting to promote bone bonding. Acid etching treatment can control the size and distribution of the holes on the implant surface, and makes the implant easierto bind to cells. Alkali treatment after acid etching can change the surface structure of the implant, so the implant has good hydrophilicity, can better perform direct interaction with proteins andcells in body fluid, and has higher biological activity.

The invention relates to a fiber porous titanium rod for repair of ischemic necrosis of femoral head. The fiber porous titanium rod comprises a fiber porous titanium rod body and a nanometer strontium apatite layer coated on the outer surface of the fiber porous titanium rod body. Diameter of the fiber porous titanium rod body is 1-2cm, height of the rod is 50-80cm, pore diameter distribution is 100-800mum, porosity is 80.0+-2.0%, and pores are communicated with each other. The fiber porous titanium rod is implanted in the femoral head with the ischemic necrosis, can replace a defect area to have strong supporting effect, can promote adhesion, multiplication and differentiation of bone cells on the basis of maintenance of characteristics of an original fiber porous material, effectively induces formation of bones, and enhances osseointegration and bone bonding.

The invention belongs to the technical field of dental implants and in particular relates to a self-tapping dental implant. The self-tapping dental implant comprises a body, wherein a screw-in end anda crown end used for connecting with the dental implant are respectively arranged at two ends of the body; and a double-headed screw thread starting from the body and ending at an mouth edge of the crown end is arranged on an outer side face of the crown end. The self-tapping dental implant disclosed by the invention has the beneficial effects that friction force formed by screwing the double-headed screw thread and a ridge crest is weak, and the dental implant is conveniently self-tapped; destruction of bones on the ridge crest is the minimal in the implanting process, the stress is low, thedistribution is uniform, and local stress concentration is avoided; an area attachment area is enlarged, the bone bonding strength of the implant is easily improved, and the later stress level is low; under external load and constraint conditions, stress and strain stressed by cortical bones are decreased, local stress concentration is difficult to cause, and the teeth are very strong; and when being screwed into the ridge crest, the self-tapping dental implant is low in resistance, excellent in self-tapping property, capable of containing alveolar bones at a high quantity and high in stability.

The invention relates to a method for simultaneously improving the degradation rate and biological activity of iron-based implants, which belongs to the technical field of biomedical implant design and manufacturing. A scheme is characterized in that iron powder and calcium sulfate are used as raw materials, through an alternative laser melting process, an iron-based implant is obtained, and the iron-based implant comprises the following components in mass percentage: 0.5-12% of calcium sulfate; and 88-99.5% of iron. The method solves the problem that the conventional iron-based implant degrades too slowly, and controls the degradation rate within a reasonable range; in addition, the calcium sulfate can form a bone-like apatite layer by degradation, forms good bone bonding with the tissue,and increases the biological activity of the iron-based implant. At the same time, the method can realize the uniform dispersion of calcium sulfate in an iron matrix and maintain the structural integrity by optimizing the preparation process, and fully exerts the effect of improving the degradation behavior and biological activity of the iron-based implant.

The present invention relates to a bone repair material composition comprising a bone cement component and nano silicon nitride, wherein the bone cement component comprises magnesium oxide and sodiumdihydrogen phosphate, and the weight ratio of the nano silicon nitride to the bone cement component is 1: (1.5-9). The bone repair material prepared according to the invention has dual effects of resisting infection and promoting bone growth, not only inhibits bacterial adhesion, but also promotes adhesion and proliferation of osteoblasts, and can play a role in resisting infection and improving bony combination between an implant and a host bone after being implanted into a body.

The invention provides a multi-component bone bonding material, which relates to the field of medical materials, comprising an isocyanate composition, a castor oil polyol composition, a catalyst, anda particle size of 10-100um, and the inorganic particles contain a water-absorbent sulfate and a poorly soluble calcium salt, wherein the water-absorbent sulfate is distributed on the surface of the inorganic particles. The invention also provides a use method of a multi-component bone bonding material, wherein the obtained bonding material has the advantages of high bone bonding strength, no hindrance to the growth of broken bones and the like, in particular, is suitable for use in a human body temperature environment, and overcomes the negative influence on the performance of the bonding material under the environment with water.

The invention discloses an oral implant with an asymmetric thread structure. The oral implant comprises an implant part c, an implant part b and an implant part a in sequence from top to bottom; a column body is arranged at the contact part of the implant part c and a compact bone; the implant part b adopts a cone with a cambered surface; the bottom surface of the implant part a is a circular arc surface; an asymmetric thread is arranged on the oral implant; the depth of the asymmetric thread is gradually decreased from the implant part b to the implant part c and the implant part a on the two sides of the implant part b; the inclined angle between the upper edge of the asymmetric thread and the horizontal plane is smaller than that between the lower edge of the asymmetric thread and the water level; a circular arc surface is arranged at the transition part of either the upper edge or the lower edge of the asymmetric thread and the vertical surface of the bottom diameter of the asymmetric thread; the helix angle of the asymmetric thread is varied along with the variation of the diameter of the implant; the thread structure can transfer a bite force well, has a good retention force, and can avoid stress concentration; the screw pitch is reasonable, the helix angle has self-lock performance, and the stability is improved; the variable thread depth can reach the optimal bone bonding strength.

To provide a surface modified implant made with titanium or a titanium alloy in which a bone bonding can be made easily and certainly as compared with conventional ones and treating method thereof, the surface of the implant made with titanium or the titanium alloy is treated with polyphosphoric acid and basic fibroblast growth factor (bFGF), and the method comprises treating with a polyphosphoric acid solution having a concentration of 0.05 to 70% by weight and with a basic fibroblast growth factor (bFGF) solution having a concentration of 1 to 500 ng / ml, or treating with a mixed solution having the concentration of the polyphosphoric acid of 0.05 to 70% by weight and the concentration of the basic fibroblast growth factor (bFGF) of 1 to 500 ng / ml.

The invention discloses a superfine crystal pure titanium oral micro-implant and a preparation method thereof, belongs to the field of oral implants, specifically to the superfine crystal pure titanium oral micro-implant, and is used for solving the problem that the existing pure titanium micro-implant is low in strength and small in bone bonding area. The micro-implant is prepared from superfine crystal pure titanium, and the diameter is 2.5 to 3.0 mm; an in-bone part of the micro-implant is provided with screw threads of which the surfaces are subjected to roughening treatment; the neck part of the micro-implant is a smooth surface, and the bottom of the micro-implant is an arc surface. The micro-implant is manufactured by using a high-strength superfine crystal pure titanium material, and the shape of the screw threads on the surface of the micro-implant is optimized, so that the stress is reduced, and meanwhile, the bone bonding area is increased. According to the superfine crystal pure titanium oral micro-implant and the preparation method thereof, the strength of the micro-implant can be effectively improved, the bone bonding area can be effectively increased, the fracture risk of the micro-implant can be reduced, and the service life of the micro-plant can be prolonged.

The invention provides a dental implant with a reducing thread. The dental implant comprises an implant body. At least one continuous thread is arranged from the root to the periphery of the neck of the implant body. The thread pitch of the thread from the root to the neck is gradually reduced, containing grooves are formed between the two side faces of adjacent thread teeth, and the opening widths of the containing grooves are smaller than the groove bottom widths. One thread is adopted, the bone bonding strength of the implant can be improved, the adhesion rate of osteoblast is improved, proliferation and differentiation of the osteoblast implant surface in the early implantation period are obviously promoted, and the planting survival rate is greatly increased.

The invention discloses a surface chemical modification method and application of a dental implant combined with an alveolar bone, and belongs to the field of biological medicine. The method comprises the following steps: taking titanium or titanium alloy as a dental implant combined with an alveolar bone, carrying out grinding, polishing and double acid etching on the surface of the titanium or titanium alloy to obtain frosted and acid-etched titanium or titanium alloy, and then carrying out ultraviolet light treatment and alkali liquor treatment to obtain the dental implant with a hydrophilic multistage microporous layer on the surface, then, 3-aminopropyltriethoxysilane is subjected to hydrogel treatment and then is spin-coated on the surface of the dental implant subjected to surface treatment, and the 3-aminopropyltriethoxysilane self-assembly layer is formed. Through the chemical modification method, the dental implant and an alveolar bone bonding interface are effectively reacted, the bonding rate of bone cells and the titanium or titanium alloy dental implant can be increased, the dental implant is used for hard tissue repair, the clinical success rate is increased, and the shedding rate in a dental operation is effectively reduced.

The invention provides a dental implant system. The dental implant system comprises a base and an implant, wherein the base is connected with the implant in a matching way through an inner connectionstructure; the inner connection structure comprises a first torx ligand which is arranged in the implant, and a second torx ligand which is arranged at the bottom of the abutment; the first torx ligand can be matched with the second torx ligand, so that the abutment is connected with the implant. Through design of the structure of the implant and the abutment, a tight connection can be formed. A surface modification technology is adopted to treat the surface interface of the implant, so that the performance of bone bonding is improved, thereby prolonging the service life and improving the reliability of the implant system.