9 results about "Bone bonding" patented technology

A kind of preparation method of high-toughness super-hydrophilic titanium-zirconium alloy dental implant, comprising the following steps: step 01, preparation of titanium sponge and zirconium sponge;Step 02, Ti-Zr binary alloy ingot is melted by using vacuum melting furnace;Step 03, heat preservation of Ti-Zr binary alloy ingot;Step 04, Ti-Zr binary alloy ingot is opened by using free forging process;Step 05, equal-diameter angular extrusion of Ti-Zr binary alloy ingot blank;Step 06, the blank is soaked in etching liquid for 6-12 hours, and then surface finishing and cleaning are carried out;Step 07, mechanical treatment is carried out on the blank;Step 08, Ti-Zr binary alloy rod is finely ground, and the implant semi-finished product is obtained after machining by the heart machine, and then sand blasting treatment is carried out after cleaning and drying;Step 09, super-hydrophilic acid etching treatment is carried out on the implant semi-finished product after sand blasting. It has good biocompatibility, good bone bonding performance and excellent mechanical properties.

The invention discloses a PEKK craniomaxillofacial patch and a processing method thereof, and relates to the technical field of medical instruments. According to the invention, interference of medical images and bone loss caused by stress shielding are avoided, biocompatibility is improved, and integration of multiple functions is realized. The patch comprises an outer soft tissue attaching layer, a middle layer and an inner osseointegration layer, a vein-imitating graded micro-nano structure is arranged on the surface of the outer soft tissue attaching layer; the vein-imitating hierarchical micro-nano structure comprises a micron-sized vein network and a nano-sized microstructure arranged in a gap of the micron-sized vein network; the micron-sized vein network comprises a plurality of main veins which are connected to form an imitated vein network; each main leaf vein is connected with a plurality of side leaf veins; each side vein is connected with a plurality of small veins; the nano-scale microstructure is a nano column; the inner side synostosis layer is of a porous structure; the outer soft tissue attaching layer, the middle layer and the inner bone combining layer are all made of PEKK materials. The invention further discloses a processing method of the patch.

The present application relates to a kind of promote bone antibacterial biological function material and its preparation method, belong to laser application technical field.The present application is after polishing nickel-titanium alloy material ultrasonic and dry, using femtosecond laser direct writing technology, through the laser flux of synergic control processing process, processing translation table moving speed and scanning pitch and other processing parameters, prepare the self-organizing composite periodic micro-wave groove structure;It is again after being handled by anodic oxidation, form rich nanometer hole on the basis of the structure, prepare to get groove-micro-wave groove-micropore three-level micro-nano composite structure;Subsequently, the three-level micro-nano composite structure prepared is placed in the alkaline Tris buffer solution containing hydrochloric acid dopamine, and the polydopamine coating is attached;Subsequently, the groove-micro-wave groove-micropore three-level micro-nano composite structure with polydopamine coating is placed in silver nitrate solution, to load nano-silver on its surface, finally, the biological function material with good bone bonding ability, promote bone growth ability and antibacterial ability is prepared.

Proposed is a non-fixing implant made of a raw material including a biomaterial and a ceramic-based composite material having excellent osteoconductivity in addition to a polymer. The non-fixing implant can be accurately secured to a gap between the skull and the bone flap and can be conveniently used. Further proposed is a method of manufacturing the non-fixing implant. The non-fixing implant includes a flexible wedge deformable to conform to the external contour of the bone flap and a plurality of wings connected to an upper or lower portion of the flexible wedge and extending to both sides of the flexible wedge. The wings have a porous structure. The wings on one side will be positioned on the bone flap and the wings on the other side will positioned on the skull. The non-fixing implant has the advantage of being capable of accurately filling a defect formed by craniotomy, has improved biocompatibility and bone bonding ability, and allows tissue invasion.

The application discloses a screw bone combination rate determination method and device, equipment and storage medium, relates to the field of medical engineering, and comprises the following steps: acquiring multi-dimensional projection data of a screw sample to construct target three-dimensional body data corresponding to a target screw, to determine a screw main shaft corresponding to the target screw and a target pitch, and establishing a target parameter model based on the target pitch; performing coordinate conversion on a thread surface point corresponding to the target parameter model to obtain a target plane expansion image corresponding to the target parameter model, and determining a target area corresponding to the target screw based on the target plane expansion image; determining a target grid model corresponding to the target screw based on the target parameter model, determining a target combined bone region corresponding to the target screw based on the target grid model, determining a contact interface point set on the target grid model based on the target combined bone region, and determining a screw bone combination rate corresponding to the target screw based on the contact interface point set and the target area. The application improves the calculation precision of the screw bone combination rate.

The application discloses a 3D-printed implant with arc-shaped pipelines and a preparation method thereof, which is used for being implanted into an alveolar bone implantation nest of a patient, and the implant comprises a dense core body and a bone bonding part wrapped outside the dense core body; the bone bonding part comprises a first porous part and a second porous part; the first porous part is connected with the top surface of the second porous part; a plurality of arc-shaped pipelines are arranged in the first porous part; the arc-shaped pipelines are provided with openings at two ends and are communicated with the outside through the openings; the arc-shaped pipelines are extended into a cleaning part through the openings to clean the interiors of the arc-shaped pipelines. The interiors of the arc-shaped pipelines can load drugs (such as BMP-2, VEGF, PDGF and the like) to induce the rapid growth of bone tissues. The implant has the characteristics of good strength, matched elastic modulus of the bone bonding part and the patient and easy cleaning. The implant has a wide indication and is suitable for various edentulous patients, especially for the cases of insufficient alveolar bone mass or bone density.

The invention relates to the technical field of biological materials, discloses a silk fibroin composite hard material as well as a preparation method and application thereof, and aims to solve the problems that a pure silk fibroin hard material is insufficient in toughness and easy to break. The preparation method comprises the following steps: preparing degummed silk; recovering sericin protein; dissolving degummed silk to obtain a silk fibroin solution; adding the recycled sericin protein into the silk fibroin solution to form a composite solution; and carrying out dialysis, solvent replacement and drying on the composite solution to finally obtain the composite material. The preparation method is characterized in that homologous sericin and silk fibroin are compounded, and the microphase structure of the sericin and the silk fibroin is remodeled. The structural remodeling optimizes the internal stress distribution of the material, so that the fracture strain is remarkably improved while the obtained composite material keeps high modulus, and good balance between rigidity and toughness is realized. The material can be further compounded with hydroxyapatite to enhance osseointegration activity, and is suitable for manufacturing artificial bone cartilage restoration and other medical implants and tissue engineering scaffolds.

The invention relates to a mineralized collagen composite bone bonding and filling material and a preparation method thereof, the preparation method comprises the following steps: mineralized collagen composite powder, a high-molecular polymer and a polymerization initiator are mixed into a first mixture, and the high-molecular polymer at least comprises polymethyl methacrylate; preparing a second mixture taking methyl methacrylate as a main liquid component; mixing the first mixture with the second mixture to form a third mixture; placing the third mixture in an environment with the temperature of 10-25 DEG C and keeping for 2-5 minutes; the temperature of the environment where the third mixture is located is increased to 35-37 DEG C at the preset heating rate of 0.5-1.0 DEG C / min; and keeping the third mixture in an environment of 35-37 DEG C for 10-20 minutes until the third mixture is completely cured. According to the technical scheme, through a specific curing process of low-temperature pre-curing, slow heating and constant-temperature hardening, a uniformly distributed microporous structure can be spontaneously formed in the material curing process, and the biocompatibility and osseointegration capability of the material can be improved without depending on a complex process.

The application discloses a kind of multi-coordinated control composite bone bonding system and its preparation method and application.The composite bone bonding system includes powder component and liquid buffer component.The powder component contains phosphoserine, tetracalcium phosphate and other basic calcium phosphate salt;The mass content of phosphoserine in the powder component is 10%~50%, and the mass content of tetracalcium phosphate in the powder component is 10%~50%.The liquid buffer component is the mixed solution of citric acid and disodium hydrogen phosphate, and the pH value range is 4.4~9.4.By mixing powder component and liquid buffer component, the paste-like composite bone bonding system can be made.The application realizes the reaction control of acid-base neutralization by the material selection of powder component and the pH adjustment of liquid buffer component, reduces the solidification temperature rise, and inhibits local overheating, and the composite bone bonding system can be applied as bone repair biomaterial, dental repair biomaterial or oral implant.