21 results about "Bone bonding" patented technology

The invention discloses a preparation method of a coating loaded with an antibacterial coating. The preparation method comprises the following steps: pretreating a titanium sheet, preparing an electrolyte, preparing Ti (at) col-I, preparing Carat UiO-66, preparing a Ti (at) col-I (at) Carat UiO-66 coating, and preparing a Ti (at) col-I (at) Carat UiO-66 (at) LBL coating. According to the coating preparation method and the implant provided by the invention, the carvacrol-loaded UiO-66 mineralized collagen coating is prepared by utilizing an electrochemical deposition and layer-by-layer self-assembly technology, so that the surface osseointegration capability of a titanium-based material is improved, the surface of the titanium-based material is endowed with antibacterial capability, and infection around the implant is reduced; the initial stability and the clinical curative effect are improved.

The invention discloses a high-strength low-immunoreaction bone bonding material and a preparation and application method thereof. The bone binding material comprises tetracalcium phosphate, serine phosphate, magnesium phosphate and a sodium citrate solution. According to the preparation method, tetracalcium phosphate, phosphoserine, magnesium phosphate powder and a sodium citrate solution are fully mixed and reacted by utilizing a hedging device consisting of a screw injector and a connecting pipe. And extruding the mixed liquid material through a filter membrane to complete the preparation of the bone adhesive material. The bone binding material can be used for preparing bionic sclerotin, binding broken bones in comminuted fractures or smearing the bone binding material to bone gaps, and in the decomposition process, the bone binding material can continuously release magnesium ions, so that the immune environment of early bone repair is regulated and controlled, the bone repair process is accelerated, and bone healing is promoted. Meanwhile, experimental data prove that the bone adhesive material provided by the invention can provide stable supporting strength, has no potential toxicity to fibroblasts, and is good in biocompatibility.

The invention belongs to the technical field of biomimetic materials, and discloses a titanium alloy implant surface biomimetic coating and a preparation method thereof.The biomimetic coating comprises a porous titanium support layer, a micron-sized porous titanium layer is prepared through plasma spraying, and then nano-hydroxyapatite is doped to improve osteoinductivity; the graphene enhancement layer is modified, a graphene oxide film is electrochemically deposited, the graphene oxide film and the titanium substrate are covalently bonded through a silane coupling agent, and strontium ions are loaded to promote osteogenic differentiation; an antibacterial active layer and in-situ reduced graphene oxide form a three-dimensional network conductive structure, tantalum-doped carbon nitride quantum dots are loaded through ultrasonic dispersion and embedded between graphene layers to form an antibacterial phase, and then magnesium silicate nanowires are subjected to hydrothermal growth to form a bioactive phase. Through triple bionic design of porous titanium, ion release / photo-thermal response and PDA adhesion, the bone bonding strength, antibacterial property, wear resistance and corrosion resistance of a coating interface are improved.

The present invention provides a high-performance conical columnar bone-level implant, which includes: an implant structure, a locking structure located below the implant structure, and an abutment structure. The application uses the implant structure for installation, which can be closely fitted with the alveolar socket of the alveolar bone to achieve stable implantation. The tip formed by setting the cutting groove can improve the implantation stability, making it have a certain self-tapping property in the horizontal direction. And a lock is pre-implanted, and the cooperation between the implant and the lock is used to achieve limit, the lock is clamped with the alveolar bone, and a stable connection with the implant is achieved. Stable limit can be achieved by inserting a rod into the interior of the alveolar bone. While installing, the internal space of the implant is squeezed, so that the pre-filled bone collagen is squeezed into the gap between the implant and the alveolar bone to complete the filling, which not only improves the implantation stability of the implant, but also can achieve the function of rapid bone bonding, shorten the recovery time of tooth implantation, and improve the service life after the implant is implanted.

The application discloses a preparation method of a near-beta TLM titanium alloy dealloying / chronological functional surface, and the method comprises the following steps: 1, heat treatment to obtain a dual-phase microstructure TLM titanium alloy substrate; 2, electrochemical dealloying to obtain a hierarchical micro-nano porous surface structure; 3, preparation of a complex solution; 4, chemical deposition of the complex solution to construct an osteogenesis and vascularization functional layer on the hierarchical micro-nano porous surface structure; and 5, electrostatic adsorption to construct an antibacterial functional layer. The osteogenesis and vascularization functional layer and the antibacterial functional layer are introduced on the dealloyed surface of the TLM titanium alloy, the surface is endowed with the chronological expression characteristics through controllable degradation release, the positive electricity and the porous structure of polylysine are used to realize synergistic antibiosis, the tannic acid induced strontium ion controllable release improves the osteogenesis and vascularization performance, the hierarchical micro-nano porous structure of the surface is beneficial to the formation of good bone bonding, the TLM titanium alloy is endowed with early antibiosis, medium and long-term osteogenesis promotion and excellent bone integration characteristics, and is used for bone defect repair.

This invention discloses a piezoelectric coating for a medical metal surface and its preparation method, belonging to the technical field of medical biomaterial implants. The piezoelectric coating preparation method comprises: performing laser ablation on the metal surface to obtain an oxidized nanocoating; then hydrothermally reacting an alkaline solution with the oxidized nanocoating under high temperature and high pressure conditions to obtain the piezoelectric coating. The metal is tantalum, titanium, or niobium, and the high temperature and high pressure conditions are 100-300°C and 1-30 MPa. This method aims to address the problems of poor bone-to-bone bonding, low mechanical strength, and poor biocompatibility of existing implant piezoelectric coatings.

A kind of preparation method of high-toughness super-hydrophilic titanium-zirconium alloy dental implant, comprising the following steps: step 01, preparation of titanium sponge and zirconium sponge;Step 02, Ti-Zr binary alloy ingot is melted by using vacuum melting furnace;Step 03, heat preservation of Ti-Zr binary alloy ingot;Step 04, Ti-Zr binary alloy ingot is opened by using free forging process;Step 05, equal-diameter angular extrusion of Ti-Zr binary alloy ingot blank;Step 06, the blank is soaked in etching liquid for 6-12 hours, and then surface finishing and cleaning are carried out;Step 07, mechanical treatment is carried out on the blank;Step 08, Ti-Zr binary alloy rod is finely ground, and the implant semi-finished product is obtained after machining by the heart machine, and then sand blasting treatment is carried out after cleaning and drying;Step 09, super-hydrophilic acid etching treatment is carried out on the implant semi-finished product after sand blasting. It has good biocompatibility, good bone bonding performance and excellent mechanical properties.

This invention belongs to the field of biomimetic materials technology and discloses a biomimetic coating for titanium alloy implant surfaces and its preparation method. The biomimetic coating comprises: a porous titanium scaffold layer, prepared by plasma spraying a micron-sized porous titanium layer, then doped with nanohydroxyapatite to enhance osteoinductivity; a modified graphene reinforcement layer, comprising an electrochemically deposited graphene oxide film, covalently bonded to the titanium substrate via a silane coupling agent, and loaded with strontium ions to promote osteogenic differentiation; and an antibacterial active layer, comprising an in-situ reduced graphene oxide layer forming a three-dimensional mesh-like conductive structure, ultrasonically dispersed and loaded with tantalum-doped carbon nitride quantum dots embedded between the graphene layers to form an antibacterial phase, followed by hydrothermal growth of magnesium silicate nanowires to form a bioactive phase. Through the triple biomimetic design of porous titanium, ion release / photothermal response, and PDA adhesion, the coating improves bone bonding strength, antibacterial properties, wear resistance, and corrosion resistance at the interface.

The invention discloses a PEKK craniomaxillofacial patch and a processing method thereof, and relates to the technical field of medical instruments. According to the invention, interference of medical images and bone loss caused by stress shielding are avoided, biocompatibility is improved, and integration of multiple functions is realized. The patch comprises an outer soft tissue attaching layer, a middle layer and an inner osseointegration layer, a vein-imitating graded micro-nano structure is arranged on the surface of the outer soft tissue attaching layer; the vein-imitating hierarchical micro-nano structure comprises a micron-sized vein network and a nano-sized microstructure arranged in a gap of the micron-sized vein network; the micron-sized vein network comprises a plurality of main veins which are connected to form an imitated vein network; each main leaf vein is connected with a plurality of side leaf veins; each side vein is connected with a plurality of small veins; the nano-scale microstructure is a nano column; the inner side synostosis layer is of a porous structure; the outer soft tissue attaching layer, the middle layer and the inner bone combining layer are all made of PEKK materials. The invention further discloses a processing method of the patch.

The present application relates to a kind of promote bone antibacterial biological function material and its preparation method, belong to laser application technical field.The present application is after polishing nickel-titanium alloy material ultrasonic and dry, using femtosecond laser direct writing technology, through the laser flux of synergic control processing process, processing translation table moving speed and scanning pitch and other processing parameters, prepare the self-organizing composite periodic micro-wave groove structure;It is again after being handled by anodic oxidation, form rich nanometer hole on the basis of the structure, prepare to get groove-micro-wave groove-micropore three-level micro-nano composite structure;Subsequently, the three-level micro-nano composite structure prepared is placed in the alkaline Tris buffer solution containing hydrochloric acid dopamine, and the polydopamine coating is attached;Subsequently, the groove-micro-wave groove-micropore three-level micro-nano composite structure with polydopamine coating is placed in silver nitrate solution, to load nano-silver on its surface, finally, the biological function material with good bone bonding ability, promote bone growth ability and antibacterial ability is prepared.

The invention relates to the field of biological medicine, in particular to a GLUL deubiquitinase targeting chimera and application thereof. The invention focuses on the function of GLUL in osteogenic differentiation of BMSCs, discovers a new target for intervening in osteogenic differentiation of T2DM jaw bone BMSCs, and reveals the molecular mechanism of T2DM mediated GLUL ubiquitination modification, damage of GLUL protein homeostasis and inhibition of osteogenic differentiation of jaw bone BMSCs. The invention focuses on the ability of GLUL-DUBTAC to maintain the steady state of the GLUL protein, directly targets the GLUL ubiquitin chain, does not influence the programmed degradation of the GLUL non-ubiquitination pathway, realizes the resynthesis of the GLUL protein ligand-target protein, can complete the inverse degradation of necessary GLUL protein by using the catalyst amount of GLUL-DUBTAC, is innovatively used for enhancing the osteogenic differentiation ability of T2DM jaw bone BMSCs, and has the advantages of high stability, high efficiency, high stability and the like. The bottleneck problem that the T2DM reduces the bone combination rate in the healing stage of the implant is solved.

Proposed is a non-fixing implant made of a raw material including a biomaterial and a ceramic-based composite material having excellent osteoconductivity in addition to a polymer. The non-fixing implant can be accurately secured to a gap between the skull and the bone flap and can be conveniently used. Further proposed is a method of manufacturing the non-fixing implant. The non-fixing implant includes a flexible wedge deformable to conform to the external contour of the bone flap and a plurality of wings connected to an upper or lower portion of the flexible wedge and extending to both sides of the flexible wedge. The wings have a porous structure. The wings on one side will be positioned on the bone flap and the wings on the other side will positioned on the skull. The non-fixing implant has the advantage of being capable of accurately filling a defect formed by craniotomy, has improved biocompatibility and bone bonding ability, and allows tissue invasion.

The application discloses a screw bone combination rate determination method and device, equipment and storage medium, relates to the field of medical engineering, and comprises the following steps: acquiring multi-dimensional projection data of a screw sample to construct target three-dimensional body data corresponding to a target screw, to determine a screw main shaft corresponding to the target screw and a target pitch, and establishing a target parameter model based on the target pitch; performing coordinate conversion on a thread surface point corresponding to the target parameter model to obtain a target plane expansion image corresponding to the target parameter model, and determining a target area corresponding to the target screw based on the target plane expansion image; determining a target grid model corresponding to the target screw based on the target parameter model, determining a target combined bone region corresponding to the target screw based on the target grid model, determining a contact interface point set on the target grid model based on the target combined bone region, and determining a screw bone combination rate corresponding to the target screw based on the contact interface point set and the target area. The application improves the calculation precision of the screw bone combination rate.

The invention relates to a Ti6Al4V surface micro-arc zinc oxide modified coating and a detection method and application thereof, and belongs to the technical field of material surface coating preparation. In order to solve the problems that an existing titanium oxide coating is poor in antibacterial performance and cannot be applied to a special oral environment, a zinc modified coating is prepared on the surface of Ti6Al4V through micro-arc oxidation, the zinc content of the zinc modified coating is 0-5.16%, a plurality of holes with the diameter being 1-2 micrometers are evenly distributed in the zinc modified coating, the contact angle of the zinc modified coating is 35-60 degrees, and the surface of the zinc modified coating is coated with the antibacterial coating. An oral microenvironment is simulated through antibacterial experiments and bacterium-cell co-culture, and it is verified that the antibacterial performance of the material is improved through introduction of zinc. In addition, the coating plays a role in promoting adhesion, proliferation and osteogenic differentiation capability of MC3T3-E1 cells in conventional and high-glucose states, and the coating is found to have better antibacterial property and hydrophilicity, and optimizes the osseointegration capability of the implant.

The present invention relates to the field of bone implant technology, and in particular to a novel implant surface treatment technology, the method comprising the following steps: selecting hydroxyapatite powder, uniformly mixing deionized water and hydroxyapatite powder to prepare a hydroxyapatite suspension with a concentration of 8 mg / ml; sealing the screw opening on the upper part of the implant, immersing the implant in the suspension for 1 minute, and then transferring it to a dryer and drying it at 60°C for 2 minutes. The present invention has the advantages of being able to perform femtosecond laser combined with hydroxyapatite suspension evaporation solvent crystallization on the surface of the implant to improve the soft tissue sealing and bone bonding ability around the implant, and improve the implant repair and aesthetic effect. By proposing a femtosecond laser combined with hydroxyapatite suspension evaporation solvent crystallization method to treat the implant surface, while constructing the micro-nano morphology of the implant surface, a calcium-phosphorus coating is melted to improve the biological activity of the implant surface, without contacting the implant surface, and the treatment process is pollution-free.

The application discloses a 3D-printed implant with arc-shaped pipelines and a preparation method thereof, which is used for being implanted into an alveolar bone implantation nest of a patient, and the implant comprises a dense core body and a bone bonding part wrapped outside the dense core body; the bone bonding part comprises a first porous part and a second porous part; the first porous part is connected with the top surface of the second porous part; a plurality of arc-shaped pipelines are arranged in the first porous part; the arc-shaped pipelines are provided with openings at two ends and are communicated with the outside through the openings; the arc-shaped pipelines are extended into a cleaning part through the openings to clean the interiors of the arc-shaped pipelines. The interiors of the arc-shaped pipelines can load drugs (such as BMP-2, VEGF, PDGF and the like) to induce the rapid growth of bone tissues. The implant has the characteristics of good strength, matched elastic modulus of the bone bonding part and the patient and easy cleaning. The implant has a wide indication and is suitable for various edentulous patients, especially for the cases of insufficient alveolar bone mass or bone density.

The invention relates to the technical field of biological materials, discloses a silk fibroin composite hard material as well as a preparation method and application thereof, and aims to solve the problems that a pure silk fibroin hard material is insufficient in toughness and easy to break. The preparation method comprises the following steps: preparing degummed silk; recovering sericin protein; dissolving degummed silk to obtain a silk fibroin solution; adding the recycled sericin protein into the silk fibroin solution to form a composite solution; and carrying out dialysis, solvent replacement and drying on the composite solution to finally obtain the composite material. The preparation method is characterized in that homologous sericin and silk fibroin are compounded, and the microphase structure of the sericin and the silk fibroin is remodeled. The structural remodeling optimizes the internal stress distribution of the material, so that the fracture strain is remarkably improved while the obtained composite material keeps high modulus, and good balance between rigidity and toughness is realized. The material can be further compounded with hydroxyapatite to enhance osseointegration activity, and is suitable for manufacturing artificial bone cartilage restoration and other medical implants and tissue engineering scaffolds.

The invention relates to a mineralized collagen composite bone bonding and filling material and a preparation method thereof, the preparation method comprises the following steps: mineralized collagen composite powder, a high-molecular polymer and a polymerization initiator are mixed into a first mixture, and the high-molecular polymer at least comprises polymethyl methacrylate; preparing a second mixture taking methyl methacrylate as a main liquid component; mixing the first mixture with the second mixture to form a third mixture; placing the third mixture in an environment with the temperature of 10-25 DEG C and keeping for 2-5 minutes; the temperature of the environment where the third mixture is located is increased to 35-37 DEG C at the preset heating rate of 0.5-1.0 DEG C / min; and keeping the third mixture in an environment of 35-37 DEG C for 10-20 minutes until the third mixture is completely cured. According to the technical scheme, through a specific curing process of low-temperature pre-curing, slow heating and constant-temperature hardening, a uniformly distributed microporous structure can be spontaneously formed in the material curing process, and the biocompatibility and osseointegration capability of the material can be improved without depending on a complex process.

The application discloses a kind of multi-coordinated control composite bone bonding system and its preparation method and application.The composite bone bonding system includes powder component and liquid buffer component.The powder component contains phosphoserine, tetracalcium phosphate and other basic calcium phosphate salt;The mass content of phosphoserine in the powder component is 10%~50%, and the mass content of tetracalcium phosphate in the powder component is 10%~50%.The liquid buffer component is the mixed solution of citric acid and disodium hydrogen phosphate, and the pH value range is 4.4~9.4.By mixing powder component and liquid buffer component, the paste-like composite bone bonding system can be made.The application realizes the reaction control of acid-base neutralization by the material selection of powder component and the pH adjustment of liquid buffer component, reduces the solidification temperature rise, and inhibits local overheating, and the composite bone bonding system can be applied as bone repair biomaterial, dental repair biomaterial or oral implant.

The invention provides a bionic gradient porous nickel-titanium alloy implant which comprises a dental crown, an abutment and an implant body, the implant body is conical, a thread is arranged outside the implant body, and the implant body can be screwed into an alveolar bone in an oral cavity to provide enough support for the implant body; a position for fixing the abutment is arranged at the upper end of the interior of the implant, and the abutment is mounted on the implant through a central locking screw; a dental crown similar to teeth is mounted at the upper end of the abutment; the body and the threaded section of the implant are respectively of a gradient porous structure with porosity in gradient change; the body of the implant adopts a bionic bone trabecular pore structure and / or a spongy pore structure, and the threaded section of the implant adopts the bionic bone trabecular pore structure and / or the spongy pore structure. The implant adopting the technical scheme provided by the invention not only can maintain good mechanical properties, but also can reduce stress concentration, enhance osseointegration and promote angiogenesis and cell differentiation.

The present invention provides a multi-layer hybrid coating with a biomimetic cell membrane structure and a preparation method thereof. For the first time, by mimicking the cell membrane structure, the hydrophobicity and bioactivity are organically combined in the same coating, solving the problems of poor tissue integration and osteogenesis performance of traditional organic hydrophobic coatings. Moreover, a transition layer mainly composed of MgF2 is used to enhance the interfacial bonding force between the coating and the magnesium substrate, improving the mechanical stability of the coating and the reliability during long-term use. And through the verification of subcutaneous implantation experiments in rats, it is proved that the coating has excellent in vivo corrosion resistance and biocompatibility, can effectively inhibit the in vivo corrosion of magnesium-based materials, and has good tissue binding potential. In summary, the multi-layer hybrid coating with a biomimetic cell membrane structure and the preparation method thereof proposed by the present invention can not only inhibit the biological corrosion of magnesium, but also have the potential to promote bone bonding and generation, especially in the fields of orthopedics and dental restoration, etc., and has broad application prospects.