The application discloses a multifunctional
composite coating for a
zinc-based
implant, which is prepared on the surface of the
zinc-based
implant, and is prepared by using poly-
tannic acid as a bottom layer and
grafting epsilon-
polylysine on the bottom layer through a
covalent bond; the application also discloses a preparation method of the
composite coating, which comprises the following steps: preparing a poly-
tannic acid bottom layer on the surface of the
zinc implant, and then
grafting epsilon-
polylysine to obtain a zinc-based implant with the multifunctional
composite coating, and the zinc-based implant is applied to the field of implants related to biological and pharmaceutical materials. The multifunctional composite
coating can induce
platelet adhesion and activation, trigger a blood
coagulation cascade reaction, and quickly form a stable blood coagulation layer to provide an ideal microenvironment for bone repair; meanwhile, the introduction of epsilon-
polylysine enables the
coating to have a strong and long-lasting contact antibacterial capacity, and the two can synergistically promote early osteogenesis; the preparation process is simple, the conditions are mild, the raw materials have good
biocompatibility, and the multifunctional composite
coating is suitable for surface functionalization modification of various implant instruments such as zinc-based bone nails,
bone plates and bone scaffolds.