116 results about "Implant surface" patented technology

The invention belongs to the technical field of medical materials, and relates to a titanium-based implant surface dual drug release system and a preparation method and application thereof. Comprising a titanium-based implant and a hydrogel layer attached to the surface of the titanium-based implant, the surface of the titanium-based implant is of a nanotube array structure, zinc oxide nanoparticles and up-conversion luminescent material particles are arranged between the titanium-based implant and the hydrogel layer, and MgO2 nanoparticles are loaded in the hydrogel layer; wherein the material of the up-conversion luminescent material particles is NaYF4: Yb < 3 + >, Er < 3 + >, and the hydrogel layer is composed of gelatin-sodium alginate hydrogel. The titanium-based implant surface dual-drug release system provided by the invention can realize loading of different drugs, can be used for treating various diseases, has a better time sequence control effect, is long in action time and low in cost, and has a wide application prospect.

The invention discloses a cranio-maxillofacial dissimilar metal bone implant with an antibacterial property and a preparation method thereof, and relates to the technical field of medical implant prostheses, the preparation method comprises the following steps: step 1, preparing a nano-silver-antibacterial peptide GL13K composite peptide solution with the antibacterial property; 2, based on the selective laser melting technology, titanium alloy powder is prepared into a porous framework; 3, melting zinc powder, and filling pores of the porous skeleton with the molten zinc powder to obtain a semi-finished heterogeneous metal bone implant; step 4, depositing the nano-silver-antibacterial peptide GL13K composite peptide solution prepared in the step 1 on the surface of the semi-finished heterogeneous metal bone implant prepared in the step 3 through a pulse electrodeposition method to obtain a finished heterogeneous metal bone implant; the prepared finished heterogeneous metal bone implant has a remarkable antibacterial effect, the postoperative infection risk can be reduced, and the nano-silver-antibacterial peptide GL13K composite peptide can further promote osteoblast attachment and proliferation and accelerate the bone healing process.

The invention provides a multi-source data fitting method and system for oral edentulous jaw implantation, and the method comprises the steps: S1, assembling a scanning rod on an implant of the oral cavity of a patient, carrying out the intraoral three-dimensional scanning of the scanning rod, and obtaining the intraoral scanning data of the three-dimensional positions of all implants; s2, assembling an implant surface scanning positioner on the first implant, performing extraoral three-dimensional photography on the facial information of the patient and the visual target, and obtaining the facial information of the patient and three-dimensional position facial scanning data of the first implant corresponding to the facial information of the patient; and S3, performing three-dimensional coordinate system alignment processing on the three-dimensional position intraoral scanning data of all the implants and the three-dimensional position facial scanning data of the first implant, so that the three-dimensional position intraoral scanning data of all the implants are registered with the facial information of the patient, and generating a temporary restoration model. According to the invention, the precise relation between all the implants in the oral cavity and the facial information of the patient can be established, so that the restoration adaptive to the personalized features of the facial of the patient is generated.

The invention provides a novel implant surface treatment method and device, and the method comprises the following steps: carrying out sand blasting treatment on an implant by adopting TA4G medical titanium sand, and controlling the sand blasting parameters to be that the air pressure is 0.18-0.25 Mpa, the distance between a spray gun nozzle and the implant is 3-8 mm, the single sand blasting time is 5-13 seconds, and the sand blasting times is 2-5; then carrying out acid etching treatment on the implant subjected to sand blasting by using a mixed acid solution of sulfuric acid and hydrochloric acid, wherein the concentration of the hydrochloric acid is 18-36%, and the concentration of the sulfuric acid is 15-48%; and finally, cleaning the implant subjected to acid etching treatment. The particle size of TA4G medical titanium sand used in the sand blasting treatment is 40-80 meshes. The invention provides a novel sand blasting and acid etching surface treatment process, provides a better implant surface treatment solution, not only solves the problems in the prior art, but also brings about optimized surface structure, enhanced hydrophilicity and bone combination rate, reduced material pollution and stronger parameter controllability. Therefore, a better choice is provided for manufacturing and clinical application of the dental implant.

The invention belongs to the technical field of biomimetic materials, and discloses a titanium alloy implant surface biomimetic coating and a preparation method thereof.The biomimetic coating comprises a porous titanium support layer, a micron-sized porous titanium layer is prepared through plasma spraying, and then nano-hydroxyapatite is doped to improve osteoinductivity; the graphene enhancement layer is modified, a graphene oxide film is electrochemically deposited, the graphene oxide film and the titanium substrate are covalently bonded through a silane coupling agent, and strontium ions are loaded to promote osteogenic differentiation; an antibacterial active layer and in-situ reduced graphene oxide form a three-dimensional network conductive structure, tantalum-doped carbon nitride quantum dots are loaded through ultrasonic dispersion and embedded between graphene layers to form an antibacterial phase, and then magnesium silicate nanowires are subjected to hydrothermal growth to form a bioactive phase. Through triple bionic design of porous titanium, ion release / photo-thermal response and PDA adhesion, the bone bonding strength, antibacterial property, wear resistance and corrosion resistance of a coating interface are improved.

The invention belongs to the field of dental implants, and particularly relates to a preparation method and device of a zirconium oxide implant surface osteogenesis-promoting and antibacterial zinc phosphate coating, and the preparation method of the zinc phosphate coating comprises the following steps: S4, mixing zinc oxide, phosphoric acid, nitric acid and deionized water, and adding an additive to prepare a phosphating solution; s5, putting the phosphating solution and the zirconium oxide implant into a reaction kettle, heating the reaction kettle in a baking oven at 150-230 DEG C for 3-12 hours, and taking out the zirconium oxide implant after natural cooling; and S6, carrying out ultrasonic cleaning for 1-5 minutes by adopting deionized water, and drying in a drying oven at 40-60 DEG C to finally obtain the zirconium oxide implant coated with the zinc phosphate coating. The zinc phosphate coating is prepared on the surface of the zirconium oxide dental implant by applying a hydrothermal method, and the zirconium oxide dental implant has good mechanical properties, cytocompatibility, osteogenesis performance and antibacterial performance by changing the formula of a phosphating solution and adjusting the temperature and time of a hydrothermal reaction, and has important significance for expanding clinical application of a zirconium oxide ceramic implant material in the field of oral cavities.

A method of treating a surface of a dental implant to impart roughness to the surface is disclosed. The dental implant surface treatment method according to the present invention may comprise: a first surface treatment step for forming regular-pattern grooves in all or a part of the implant surface by means of a laser; and a second surface treatment step of imparting roughness to the grooves and the peripheries of the grooves by acid etching, the first surface treatment step including: a first laser treatment step of processing a plurality of first grooves that are continuous in a first direction and spaced apart in a second direction; and a second laser processing step of processing a plurality of second grooves that are continuous in the second direction and spaced apart in the first direction so as to form a depression at each intersection of the first grooves and the second grooves.

The invention provides a layer-by-layer self-assembled gallium-lysozyme composite antibacterial stainless steel coating and application thereof, and relates to the technical field of medical equipment. According to the composite antibacterial stainless steel coating, medical 316L stainless steel is used as a substrate material, a dopamine solution is used as a raw material, Tris salt is added to initiate a polymerization reaction of dopamine, and a polydopamine film is formed on the surface of the stainless steel; the preparation method comprises the following steps: carrying out Michael addition reaction on an easily oxidized catechol group and lysozyme containing amino and sulfydryl in an aerobic environment to form stable covalent linkage, thereby preparing the lysozyme-loaded polydopamine composite membrane. In the invention, the antibacterial composite coating aims to effectively kill biofilm embedding bacteria and prevent bacterial adhesion and biofilm formation on the surface of an implant under the condition of not hurting an organism, so that the antibacterial property of the implantable stent is improved, and the problem of clinical postoperative explosive infection of the implant is solved; and more thoughts and means and beneficial exploration are provided for treatment of chronic refractory inflammation caused by biological membranes.

The invention discloses a double-anchoring enzyme response polypeptide as well as a preparation method and application thereof, and the preparation method comprises the following steps: introducing a gelatinase response sequence GPLGV between an antibacterial peptide HHC36 and a tissue repair promoting peptide, and carrying out double-end azido modification to obtain the double-anchoring enzyme response polypeptide. The peptide for promoting tissue repair can be cell adhesion peptide, osteogenic peptide, neurogenic peptide, angiogenic peptide and other functional polypeptides. The polypeptide is double-anchored on the surface of the titanium sheet through double-end azide modification. The activity of the polypeptide is closely related to the degree of freedom of the polypeptide, two ends of the polypeptide are fixed on the surface by azide groups in a non-infection environment, cell membranes cannot be destroyed through model antibacterial mechanisms such as annular holes, and at the moment, osteogenic activity is expressed. In a bacterial infection environment, gelatinase secreted by bacteria can enable antibacterial polypeptide to be unilaterally released to obtain chain segment freedom, and the antibacterial property is improved, so that antibacterial / osteogenesis functional switching of bacterial gelatinase responsiveness is realized, and a functionalized titanium-based implant surface is constructed.

The invention belongs to the technical field of biological implant materials, and discloses a medical titanium alloy implant surface modification method and application, and the medical titanium alloy implant surface modification method comprises the following steps: grinding and polishing a titanium alloy surface, and then carrying out ultrasonic cleaning and drying in ethanol; the titanium alloy is placed in multi-arc ion plating equipment, high-purity tantalum serves as a target material, and a tantalum coating is deposited on the surface of the titanium alloy; the surface of the titanium alloy is coated with photoresist, and then a micropore array is formed in the surface of the tantalum coating through the photoetching technology; the titanium alloy is placed in the electrolyte, a Ti plate serves as a cathode, a Ta plate serves as an anode, and hydroxyapatite is deposited in a porous structure through electrochemical deposition; and removing the photoresist to expose the tantalum coating, ultrasonically cleaning with deionized water, and drying. The titanium alloy implant provided by the invention has excellent corrosion resistance, biocompatibility and mechanical properties, and makes up for the deficiency of a single material, so that the titanium alloy implant subjected to surface modification has wider application.

The invention relates to the technical field of dental implant treatment, in particular to a sand blasting medium treatment device for implant surface treatment and a circulation method. The sand blasting machine comprises a sand blasting machine body, a first feeding pipe and a first discharging pipe are arranged on the sand blasting machine body and used for inputting sand blasting media to the sand blasting machine body and discharging the used sand blasting media, a medium processing mechanism is arranged on one side of the sand blasting machine body and composed of a shell, a vibration motor and a filter plate, and the vibration motor is installed on the shell; and the filter plate is mounted on the shell and is used for vibrating along with the shell. By arranging the first vacuum conveying pump and the second vacuum conveying pump, a sand blasting medium obtained after sand blasting operation is completed can be conveyed into the shell to be filtered, the medium meeting the sand blasting requirement is conveyed into the sand blasting machine again and reused, and therefore the sand blasting cost can be saved.

The invention relates to the technical field of biological medicine, in particular to a nano-enzyme antibacterial coating for the surface of an implant and a preparation method and application of the nano-enzyme antibacterial coating. The invention provides a Fe / MSAC nano-composite used on the surface of an implant, the Fe / MSAC nano-composite is prepared by wrapping hyaluronic acid and a macrophage membrane with FeSAC containing iron monatomic catalytic sites, the Fe / MSAC nano-composite is used on the surface of the implant, is safe and stable, reduces toxic and side effects on an organism when no bacteria exist, and can be used for preparing the implant. In addition, staphylococcus aureus can be effectively killed in the presence of bacteria, the formation of a biofilm is inhibited, meanwhile, the immune response of a body is regulated, and the effect of preventing infection is achieved.

The application provides a preparation method of a high-efficiency piezoelectric coating on a titanium implant surface. The preparation method of the application uses a hydrothermal treatment and an in-situ piezoelectric deposition technology to in-situ synthesize a nano strontium titanate-noble metal piezoelectric coating on the titanium implant surface. The coating can generate a piezoelectric potential and active oxygen through ultrasonic driving to degrade extracellular polymers and kill bacteria. In addition, the piezoelectric coating can also promote the osteogenic differentiation of bone marrow mesenchymal stem cells under piezoelectric stimulation, and finally realize the effects of bioactivity, long-acting drug-resistant bacteria and high-efficiency bone integration in the body. The application can provide a new surface treatment technology and research idea for controlling the drug-resistant bacteria infection on the implant surface, help to break through the limitations of the existing theory and technology in removing bacterial infection on the titanium implant surface, and provide beneficial guidance for the control of bacterial biofilm on other parts and the prevention and treatment of related infectious diseases.

An extracellular vesicle-modified metal implant with immunoregulatory and osteoinductive dual functions achieved through use of mussel-derived adhesion peptides and azidylated extracellular vesicles o

To provide a simple method for hydrophilizing a surface of a dental implant body.SOLUTION: A method for hydrophilizing a surface of a dental implant body includes drying the implant body after immersing it in ozone nanobubble water. Even when the implant body is exposed to atmosphere before being immersed in the ozone nano-bubble water and a surface thereof becomes contaminated and hydrophobized by organic substances such as hydrocarbons in the atmosphere, the surface contaminants are decomposed by drying the implant body after immersion in the ozone nano-bubble water, to clean the surface as well as making the surface hydrophilic, thereby facilitating acquisition of osteointegration.SELECTED DRAWING: Figure 1

The present application relates to a kind of nasal ala base subperiosteal implant retention method, belong to plastic surgery medical instrument technical field.The present application provides a kind of nasal ala base subperiosteal implant soft tissue suspension retention method and its implant and system.The method includes: implant is placed into maxillary bone subperiosteal interstice, and implant fixed wing is fixed with the soft tissue anchor point such as alar base ligament of alar elevating lip muscle using drug-loaded degradable suture and is suspended and fixed.Implant surface is provided with the microporous structure of guiding tissue ingrowth, and is provided with the drug depot recess of filling load immunomodulator temperature-sensitive hydrogel.Postoperative healing process, suture is released under the action of tension to accelerate proangiogenic factor and promote local vascularization, and temperature-sensitive hydrogel slow-release immunomodulator induces macrophage to repair type polarization, and cooperatively promotes the biological chimeric fixation of implant and soft tissue.The present application can realize the double stable retention of implant, reduces postoperative displacement risk.

A method for treating the surface of a dental implant to impart surface roughness is disclosed. The method for treating the surface of a dental implant according to the present invention includes a first surface treatment step of forming grooves in a regular pattern on the entire or part of the implant surface using a laser, and a second surface treatment step of imparting roughness to the grooves and their surroundings through acid etching. The first surface treatment step may include a first laser treatment step of processing a plurality of first grooves that are continuous in a first direction and spaced apart in a second direction, and a second laser treatment step of processing a plurality of second grooves that are continuous in the second direction and spaced apart in the first direction, forming craters at each intersection between the first and second grooves.

The invention discloses a method for removing a bacterial biofilm on the surface of an internally-fixed titanium implant through an electrochemical anodic oxidation method, and relates to the technical field of medical instruments, the method comprises the following steps: (1) placing the titanium implant with the bacterial biofilm adhered on the surface as an anode in an electrolyte for anodic oxidation treatment; (2) carrying out glycine air sandblasting on the titanium implant; and (3) standing and soaking the titanium implant in deionized water, and then taking out and drying the titanium implant. According to the method, the electrochemical anodic oxidation technology and the sand blasting technology are combined, efficient removal of the biological membrane on the surface of the titanium implant is achieved, and the problem that bacterial biological membranes are not thoroughly removed through an existing technical method is solved.

The present invention discloses an irradiation device for implant surface modification, comprising: at least one excimer lamp tube and an electrode assembly; the excimer lamp tube is disposed on the electrode assembly, the implant is located within the irradiation range of the excimer lamp tube, and the electrode assembly is electrically connected to an external power supply. The excimer lamp tube is one (or formed by multiple ones surrounding in a ring shape), and the (surrounded) irradiation area is the working area. The implant is placed in the working area for irradiation modification. The electrode assembly is at both ends of the excimer lamp tube, used to perform high-voltage and high-frequency bombardment on the rare gas in the excimer lamp tube, so as to obtain ultraviolet light with a specific wavelength, and then perform modification irradiation on the implant (which can be a denture or a bone, etc.). Through the design of the above structure, a simple modification lamp can be obtained, which is used for the surface modification of small implants, with a simple, compact structure, convenient to use, and easy to store, assemble and disassemble.

The invention relates to the technical field of implant processing, in particular to a femtosecond laser for implant processing and a control method thereof.The method comprises the steps that the bone density of alveolar bone is obtained to determine the processing mode of the femtosecond laser; determining whether the processing process of a single stage is qualified or not based on the micropore distribution density of the implant surface in the corresponding processing mode; the vibration frequency of the implant in the rotating process is determined based on the judgment result that the machining process of the single stage is unqualified, so that the weight of the balancing weight is adjusted; obtaining the edge smoothness of the micropore based on the adjusted implant to determine whether the dispersion compensation of the femtosecond laser is qualified or not, and adjusting the spacing of the diffraction grating pair based on the judgment result that the dispersion compensation is unqualified; and determining the standard deviation of the thread pitch to determine the qualification of the moving trajectory of the femtosecond laser, and optimizing the preset frequency or optimizing the pitch adjustment mode for the unqualified moving trajectory. According to the embodiment of the invention, the bone combination rate of the implant is improved.

The present invention relates to a device (1) for recording the use of one or more implants (8) inserted during surgery, the implants (8) having identifiers (10) on their implant surfaces (9). One or more implants are provided for surgery and can be used during said surgery. The device comprises a housing (2) having a housing interior (3) in which at least one light source (4) and at least one camera (5) are arranged for recording images of multiple implants (8) of a surgical set (6) before and after surgery, and an image evaluation device for evaluating images recorded before and after surgery by at least one camera (5) to identify one or more implants (8) inserted during surgery. According to the present invention, at least one light source (4) and at least one camera (5) are configured to reduce reflections on the implant surface (9) in order to adequately recognize the identifiers. The present invention further relates to a method using this type of device (1) and to the use of surface-coated implants (8).

The invention discloses preparation of a bimetallic ion hydrogel coating on the surface of a polyether-ether-ketone bone implant, which comprises the following steps: (1) providing a polyether-ether-ketone substrate material, and carrying out sulfonation and alkali neutralization pretreatment on the substrate material; (2) preparing a bioactive hydrogel coating containing magnesium ions on the surface of the material by adopting a photocuring process; and (3) preparing a bioactive hydrogel coating sample containing active magnesium / silver bimetal ions by adopting an ion permeation method. According to the hydrogel coating disclosed by the invention, the osseointegration and antibacterial and anti-inflammatory properties of the polyether-ether-ketone material are improved, meanwhile, the technological process is simplified, the production cost is reduced, and large-scale popularization and application are facilitated.

The present disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bioabsorbable material wherein the implant surface is considered hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface, and wherein the implant surface is not hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface. Wherein the ink test comprises incubating the implant in a solution consisting of an ink having a surface tension of 72 mN / m and water for 1 minute, and wherein after the implant is incubated in the solution, the ink colored implant surface is an indication of a hydrophilic implant surface. The disclosure also provides the implant for tissue reconstruction, (soft) tissue support, tissue compatibilization and / or implant repair, and the use of the implant for reconstruction, compatibilization and / or repair of tissue and / or support of (soft) tissue, respectively, where the implant is embedded in a patient. The present disclosure further provides a method of manufacturing a tissue reconstruction implant having a hydrophilic implant surface.

The present invention relates to a method for manufacturing a medical implant, particularly a medical clip, wherein the implant surface of the medical implant has a colored finish. [Solution] To improve medical clips, particularly in the form of aneurysm clips, which comprise two clamp arms 24 and a biasing element 32, it is proposed that in each case one clamp arm is positioned or formed on the free end of the biasing element, the two clamp arms are in contact with each other in a basic position and are movable to an open position so as to move away from each other against the movement of the biasing element, and that at least a portion of the surface of the clip is colored to achieve clear distinguishability of the clip, and that the clip defines at least three spatially separated clip regions 38, 46, 42, and that at least three clip regions are colored in different colors.

Methods of depositing nanoparticles onto a substrate (e.g., an implant) are provided, as are the resulting substrates (e.g., implants) formed by such deposition methods. The nanoparticles can be silver nanoparticles that provide antimicrobial or antibacterial properties to the substrate.

A device and method for documenting a use of implants inserted in an operation. The, implants include an identifier on an implant surface and implants are provided for an operation, The device includes housing with a housing interior in which at least one light source and at least one camera for recording images of a plurality of implants of a surgical set before and after an operation are positioned, and an image evaluating apparatus for evaluating the images recorded before and after the operation by the at least one camera for the purpose of determining the implant or implants inserted during the operation. According to the invention, it is provided that the at least one light source and the at least one camera are configured such that reflections on the implant surfaces are reduced for the purpose of sufficient recognition of the identifiers.

The present invention provides a silicon carbide composite substrate and its preparation method and application. The preparation method comprises the following steps: (1) performing a peeling layer implantation treatment on a donor substrate to form a peeling layer; (2) performing masking treatment on a bottom substrate and a donor substrate respectively, and then performing ion implantation treatment to form floating junctions on the bottom substrate and the donor substrate respectively, thereby obtaining a modified bottom substrate and a modified donor substrate; (3) performing debonding treatment on the modified bottom substrate and the modified donor substrate respectively, bonding the ion implanted surfaces of the two, and performing heat treatment to remove the peeling layer to obtain a semi-finished composite substrate; (4) performing masking treatment on the semi-finished composite substrate, and then performing ion implantation, debonding, and annealing to obtain the silicon carbide composite substrate. The silicon carbide composite substrate of the present invention does not require multiple epitaxy processes, and can form a deeper floating junction without high-energy implantation during the preparation process, thereby significantly reducing the preparation cost, required dose, and implantation time.

The invention relates to the technical field of implant processing, and provides an implant surface coating manufacturing method and device, and the method comprises the following steps: S1, preparing an implant, and placing the implant in a placement position; s2, processing a concave space on the surface of the implant; and S3, predetermined fusible powder is sprayed into the concave space, and a first laser beam is emitted into the concave space to melt the predetermined fusible powder.

This application relates generally to the field of implants and more specifically to drug eluting vascular stents and methods of making and using same. Specifically, this technology relates to controlled release of drug from an implant and particular from a stent without the presence of polymer or alteration of the implant surface.

The present application provides an implantation system and method for implanting a flexible neural electrode. The implantation system comprises a flexible neural electrode and an auxiliary implantation assembly. The flexible neural electrode is provided with an auxiliary implantation part. The auxiliary implantation assembly comprises a cannula assembly and a guide wire, the cannula assembly comprises an inner cannula and an outer cannula, the guide wire has a retracted state in which it is retracted within the inner cannula and an extended state in which it penetrates out of a distal end of the inner cannula, and an extended end of the guide wire is connected to the auxiliary implantation part. Wherein, when the guide wire is in the retracted state, the flexible neural electrode is in a curled state in which it is curled between the inner cannula and the outer cannula; when the guide wire is in the extended state, the flexible neural electrode moves to an intended target area along with the guide wire and unfolds, so as to transition from the curled state to an unfolded state. The above structure can achieve the objective of implantation through a small slit on the target object, and can ensure precise implantation and flat adherence of flexible neural electrodes on the surface of the implant by strategy of the auxiliary implantation assemblies.