61 results about "Titanium implant" patented technology

The invention relates to the technical field of biomedical materials, in particular to a titanium implant multifunctional composite coating with anti-active oxygen and anti-inflammatory dual performance and a preparation method of the titanium implant multifunctional composite coating. The coating is composed of a lanthanum oxide (La2O3) nano-particle layer growing on the surface of the titanium implant in situ and queen lily glycoside A (RA) loaded on the lanthanum oxide (La2O3) nano-particle layer and can continuously release La < 3 + > and RA. The preparation method comprises the following steps: performing alkali heat treatment on the titanium substrate; a La (OH) 3 coating is synthesized on the surface in situ through a hydrothermal reaction; the La2O3 nano-particles are calcined and converted into a La2O3 nano-particle layer with a porous structure; and finally loading RA through an impregnation method. The coating can effectively remove ROS, regulate immune inflammatory response, promote osteogenic differentiation and inhibit osteoclast activity, thereby remarkably promoting osseointegration. The problem of osseointegration under the osteoporosis pathological microenvironment is effectively solved, the preparation process is simple and controllable, and the composition is suitable for bone defect repair of osteoporosis patients and has important clinical application value.

The invention discloses a preparation method of an efficient antibacterial and anticorrosive titanium implant / MXene-based functional surface. The method comprises the following steps: 1, preparing an MXene-based multifunctional nano hybrid material; 2, pretreating the surface of the titanium implant; 3, preparing a compact film; and 4, functional surface preparation. According to the method, a nano hybrid material of the two-dimensional MXene nanosheet and the metal oxide is deposited on the surface of the titanium implant subjected to chemical pretreatment to form a functional surface with corrosion resistance, antibacterial performance and near-infrared light response performance, so that the corrosion resistance of a coating on the surface of the titanium implant is improved; the MXene-based multifunctional nano-hybrid material and the titanium implant / MXene-based functional surface have the advantages that the MXene-based multifunctional nano-hybrid material can be used for preparing the MXene-based functional surface, the growth of bacteria can be effectively inhibited by generating local heat effects under the irradiation of near-infrared light, excellent antibacterial performance can be given to titanium implantation, and the MXene-based multifunctional nano-hybrid material and the preparation method of the titanium implant / MXene-based functional surface have wide application prospects in functional application of biomedical coatings and titanium implants.

The invention discloses a special-shaped titanium alloy capable of enhancing bone regeneration and repair efficacy as well as a preparation method and application of the special-shaped titanium alloy. The special-shaped titanium alloy comprises a special-shaped titanium alloy base body and a porous structure attached to the special-shaped titanium alloy base body, and the porous structure is in multi-stage size distribution and comprises long-strip-shaped gullies (100-150 micrometers wide) and large holes (30-50 micrometers wide). And the morphology in the gullies shows coralline ligaments and a nest-shaped pore channel (0.5-2 microns) structure. This can provide space and sites for the growth and adsorption of osteoblasts. According to the method, a gas phase alloying (VPA) and VPD synergistic process is adopted in a breakthrough mode, a non-oxidation / nitridation coralline-shaped hierarchical pore structure is constructed on the surface of the commercial titanium implant, and it can be achieved through verification of an aging animal model that a special-shaped matrix is uniformly modified in the whole domain, the regeneration function of aging stem cells is activated, and the bone repair and regeneration effect is effectively improved.

The invention belongs to the technical field of titanium implants, and particularly relates to a functionalized titanium implant and a preparation method and application thereof. The functionalized titanium implant comprises a titanium implant body, an interface diffusion layer and a micro-texture composite coating, the interface diffusion layer and the micro-texture composite coating are sequentially overlaid on the surface of the titanium implant body, and the micro-texture composite coating comprises a micro-texture and a coating material filling the interior and the surface of the micro-texture; the microstructure is a nanocrystalline strengthened layer containing a micron-sized groove array; and the micron-sized groove array is filled with a coating material. The micro-texture composite coating functional surface is constructed on the surface of the titanium implant by adopting electromagnetic / ultrasonic coupling energy field driving, the method has the advantages of high precision, high hardness and the like, the preparation process is shortened and the time is saved through in-situ preparation of the micro-texture composite coating functional surface and a wear-resistant coating, and meanwhile, the coating / matrix interface bonding strength is remarkably improved; under the synergistic anti-attrition and anti-wear action of the microtexture and the coating, the tribological performance of the implant is remarkably improved, and the reliable service life of the implant is prolonged.

The invention discloses a titanium implant with an osteogenesis-promoting antibacterial film layer and a preparation method of the titanium implant. The preparation method comprises the following steps: forming a rod-like nano structure on the surface of the titanium implant through hydrothermal reaction; then placing the titanium implant in an osteogenesis solution, and doping strontium ions into the nanorod through ion exchange to obtain a SrTiO3 nanorod with an osteogenesis coating; the SrTiO3 nanorod is placed in an antibacterial solution, a pattern layer with osteogenesis-antibacterial performance is formed on the surface of the SrTiO3 nanorod, and the titanium implant with the osteogenesis-promoting-antibacterial film layer is obtained. The surface treatment method provided by the invention is green and environment-friendly, and an osteogenesis-promoting antibacterial functional film layer containing strontium and zinc is prepared on the surface of the titanium implant.

The invention provides a tantalum coating dental implant which is of an integrated structure and comprises an upper part, a middle part and a lower part, neck threads are arranged on the circumferential surface of the upper part, trapezoidal threads are arranged on the circumferential surfaces of the middle part and the lower part, and a self-tapping groove is further formed in the circumferential surface of the lower part; a thread-shaped surface groove is also formed in the trapezoidal thread; a hexagonal hole is formed in the top of the dental implant, a threaded hole is further formed in the bottom of the hexagonal hole, and the hexagonal hole and the threaded hole form an inner cavity stepped hole. The tantalum coating is applied to the surface of the titanium alloy, so that the mechanical strength of a matrix is guaranteed, physical shielding is formed, and release of toxic elements is prevented; the tantalum coating significantly improves the antibacterial performance and osteogenic activity of the titanium implant, and can promote adhesion, vitality, proliferation and migration of human gingival fibroblasts.

The invention belongs to the technical field of biological medicine, and provides a multifunctional fusion peptide modified 3D printing Ti implant constructed by a fusion peptide platform and a preparation method and application thereof. The antibacterial peptide KR-12 and the adhesion peptide GFOGER are simultaneously loaded on the surface of the 3D printing titanium implant through the specific targeting peptide minTBP-1. The sequence of the fusion peptide platform is divided into four main components: bioactive polypeptide sequences KR-12 and GFOGER; a connection unit (Linker); a lysine residue; a specific anchoring group minTBP-1; the composite material has specific loading and slow release capabilities, and utilizes synergistic antibacterial and osteogenesis functions to cope with continuous challenges of implant infection and insufficient osseointegration in biomedical equipment. Meanwhile, sterilization and bone regeneration promotion are achieved, and the method is of great importance to bone healing and enhancement of bone combination around the implant. In addition to the antibacterial effect, the synergistic effect of the antibacterial peptide KR-12 and the adhesive peptide GFOGER can significantly promote osteogenesis of the BMSCs.

The application provides a preparation method of a high-efficiency piezoelectric coating on a titanium implant surface. The preparation method of the application uses a hydrothermal treatment and an in-situ piezoelectric deposition technology to in-situ synthesize a nano strontium titanate-noble metal piezoelectric coating on the titanium implant surface. The coating can generate a piezoelectric potential and active oxygen through ultrasonic driving to degrade extracellular polymers and kill bacteria. In addition, the piezoelectric coating can also promote the osteogenic differentiation of bone marrow mesenchymal stem cells under piezoelectric stimulation, and finally realize the effects of bioactivity, long-acting drug-resistant bacteria and high-efficiency bone integration in the body. The application can provide a new surface treatment technology and research idea for controlling the drug-resistant bacteria infection on the implant surface, help to break through the limitations of the existing theory and technology in removing bacterial infection on the titanium implant surface, and provide beneficial guidance for the control of bacterial biofilm on other parts and the prevention and treatment of related infectious diseases.

The invention relates to a titanium implant with piezoelectric antibacterial performance and a preparation method and application thereof, a titanium material is sequentially subjected to dopamine polymerization, electrostatic spinning and auto-polymerization, and the titanium implant with the piezoelectric antibacterial performance is obtained. A precursor solution for electrostatic spinning adopts a thermoplastic polymer with a semi-crystalline structure, a piezoelectric material and a two-dimensional transition metal carbide solution, and a precursor solution for auto-polymerization adopts a macromolecular conductive monomer-organic sulfonic acid compound solution. Compared with the prior art, the titanium implant material prepared by the preparation method disclosed by the invention not only has piezoelectric self-excited antibacterial ability, but also has good biocompatibility and ability of promoting soft tissue integration, and is effective in a human body for a long time.

The invention discloses a method for removing a bacterial biofilm on the surface of an internally-fixed titanium implant through an electrochemical anodic oxidation method, and relates to the technical field of medical instruments, the method comprises the following steps: (1) placing the titanium implant with the bacterial biofilm adhered on the surface as an anode in an electrolyte for anodic oxidation treatment; (2) carrying out glycine air sandblasting on the titanium implant; and (3) standing and soaking the titanium implant in deionized water, and then taking out and drying the titanium implant. According to the method, the electrochemical anodic oxidation technology and the sand blasting technology are combined, efficient removal of the biological membrane on the surface of the titanium implant is achieved, and the problem that bacterial biological membranes are not thoroughly removed through an existing technical method is solved.

A composition tor use in treating a dental implant. Tire composition comprises a porous biodegradable polymer scaffold and a dicalciurn phosphate dihydrate (DCPD) coating within pores of the scaffold.

The application relates to a method for constructing a high-performance multi-layer coating containing hydroxyapatite on a titanium implant surface, and aims to solve the problems of poor corrosion resistance, poor antibacterial ability and poor osteogenesis ability of the existing titanium implant surface. The method comprises the following steps: one, micro-arc oxidation treatment; and two, microwave hydrothermal treatment. The application is used for constructing a high-performance multi-layer coating containing hydroxyapatite on a titanium implant surface.

The invention discloses a titanium implant surface hydrogen sequential release soft tissue combination promoting coating and a preparation method and application thereof, and belongs to the technical field of dental material preparation. The preparation method comprises the following steps: preparing micro-arc titanium oxide; the preparation method comprises the following steps: synthesizing mesoporous polydopamine nanoparticles (mPDA NPs) through a soft template method; the preparation method comprises the following steps: dissolving AB in an aqueous solution containing mesoporous polydopamine nanoparticles (mPDA NPs), uniformly mixing, carrying out centrifugal treatment, and collecting precipitate, so as to obtain AB-coated mPDA NPs; loading AB (at) mPDA NPs on the surface of micro-arc titanium oxide, and constructing on the titanium surface to obtain a hydrogen release coating HP-Mti, namely the titanium implant surface hydrogen sequential release soft tissue combination promoting coating. Based on the nano confinement effect, the hierarchical nanostructure limits the hydrolysis of AB, thereby prolonging the hydrogen production time. Meanwhile, the water contact angle is reduced due to the loading of the AB-coated mPDA nano-particles, so that the biocompatibility is favorably improved.

The invention discloses a modified titanium implant as well as a preparation method and application thereof. The modified titanium implant sequentially comprises a titanium matrix, a tetragonal phase barium titanate layer and an iron-tannic acid network structure layer from inside to outside. The modified titanium implant is obtained by taking sodium titanate as a seed layer, preparing tetragonal-phase barium titanate on the surface of a titanium substrate and then loading an iron-tannic acid network structure on the surface of the tetragonal-phase barium titanate. A barium titanate structure and an iron-tannic acid network are combined for the first time, the possibility of multifunctional triggering is given to the surface of the modified titanium implant, and the iron-tannic acid network not only can improve the biocompatibility of the surface of the modified titanium implant, but also can enhance the light absorption capacity of the material; even in the future research, an antibacterial mode triggered by multiple exogenous sources can be considered.

This invention proposes a method for preparing dental pulp stem cell exosomes and their applications, belonging to the field of exosome technology. Dental pulp stem cells from exfoliated deciduous teeth are seeded into serum-free α-MEM medium containing microparticles, insulin-like growth factor, transforming growth factor-β1, penicillin, and streptomycin for culture. Exosomes are isolated, dispersed in PBS solution, and incubated with microparticles, propylene glycol, and rhodioloside to obtain highly active dental pulp stem cell exosomes. The surface of these exosomes is then modified with shikonin and interferon to obtain dental pulp stem cell exosomes. The dental pulp stem cell exosomes prepared by this invention exhibit good affinity for titanium implant-mediated osteointegration repair materials, demonstrating good anti-inflammatory, immunomodulatory, osteogenic, and damage-reducing effects. Furthermore, the preparation method is simple, yields high output, and operates under mild conditions, showing broad application prospects.

The application discloses a titanium implant and a hydrophilic surface construction method thereof, and belongs to the technical field of medical materials; the titanium implant hydrophilic surface construction method provided by the application comprises the following steps: performing carbon spraying treatment on a pretreated titanium alloy, performing laser cladding after the carbon spraying treatment, and then performing cleaning and drying. The titanium implant prepared by using the titanium implant hydrophilic surface construction method provided by the application has high hydrophilicity and high biological activity. Moreover, the titanium implant hydrophilic surface construction method provided by the application is simple and easy to implement, convenient to operate, and low in cost, and can be widely applied to actual production.

The invention provides a method for in-situ construction of a titanate coating with a high piezoelectric coefficient on the surface of a titanium implant. The method comprises the following steps: (1) immersing a pretreated titanium implant into an alkaline solution for alkali treatment, and washing and drying to obtain an alkali-treated titanium implant; (2) putting the titanium implant subjected to alkali treatment into a hydrothermal solution for hydrothermal reaction; after the reaction is finished, washing and drying are carried out, a titanate coating is formed on the surface of the titanium implant, and the titanium implant with the titanate coating is obtained; and (3) the titanium implant with the titanate coating prepared in the step (2) is subjected to annealing treatment and then rapidly cooled to the room temperature, and the titanate coating with the high piezoelectric coefficient is obtained on the surface of the titanium implant. According to the method, alkali activation treatment, hydrothermal reaction and a rapid cooling annealing process are combined, so that the piezoelectric property and the interface bonding strength of the coating are remarkably improved.

The application discloses a titanium implant and a preparation method and application thereof, relates to the technical field of medical titanium materials, and discloses the titanium implant which comprises a titanium base, a hierarchical titanium dioxide nanotube array layer and a piezoelectric fiber layer. The titanium implant provided by the application can destroy bacterial cell membranes through positive charge traps formed on the hierarchical titanium dioxide nanotube array layer, realizes antibacterial function, and can realize anti-inflammatory function through the following steps: macrophages can be adhered to the piezoelectric fiber layer, and the piezoelectric self-stimulating electric field generated by the piezoelectric fiber layer can repolarize from pro-inflammatory M1 type macrophages to anti-inflammatory M2 type macrophages, and the titanium implant has a protective effect of reducing osteogenic damage in an inflammatory environment, and creates a good bone immune microenvironment.

A composition tor use in treating a dental implant. Tire composition comprises a porous biodegradable polymer scaffold and a dicalciurn phosphate dihydrate (DCPD) coating within pores of the scaffold.

The invention provides a dental pulp stem cell exosome as well as a preparation method and application thereof, and belongs to the technical field of exosomes. The method comprises the following steps: inoculating exfoliated deciduous tooth pulp stem cells into a serum-free alpha-MEM culture medium containing microparticles, insulin-like growth factors, transforming growth factor-beta1, penicillin and streptomycin for culturing, separating exosomes, dispersing the exosomes into a PBS solution, adding microparticles, propylene glycol and salidroside for incubation, and separating to obtain the high-activity pulp stem cell exosomes. And performing surface modification on alkannic acid and interferon to prepare the dental pulp stem cell exosome. The dental pulp stem cell exosome prepared by the invention has relatively good affinity to a titanium implant material mediated osseointegration repair material, has relatively good advantages of resisting inflammation, regulating immunity, promoting osteogenesis, reducing injury and the like, is simple in preparation method, relatively high in yield and mild in condition, and has a wide application prospect.

A method for manufacturing an implantable device is provided. The method includes laser nano-texturing a titanium surface. The method further includes applying an aqueous silver ion solution to form a silver ion complex on the nano-textured titanium surface. The method also includes reducing, using laser-assisted photocatalytic reduction, the silver ion complex to silver ion particles which are immobilized on the nano-textured titanium surface.

The invention discloses a nanocrystalline pure titanium implant design method, which comprises: carrying out severe plastic deformation on a coarse-grain pure titanium implant raw material to form a nanocrystalline material, and establishing a cylindrical implant model by using a Swiss-Nobel pure titanium implant as an implant model, describing the difference of the implant model in stress distribution by adopting a statics analysis module in an ANASY finite element software database; the invention relates to the technical field of implants.After the implant made of nanocrystalline pure titanium is loaded in the vertical direction and the cheek-tongue direction, compared with a coarse-grain pure titanium implant with the maximum equivalent stress being 56% of the strength limit of an implant material, the implant made of nanocrystalline pure titanium has the advantages that the strength of the implant is improved; a cylindrical implant model is established by taking a Swiss-Nobel pure titanium implant as an implant model, the diameter of the implant is optimized by adopting ANASY finite element software, and the maximum equivalent stress of bone tissues around the oral implant is 52.3 MPa, which is completely sufficient to meet the requirement of serving as the oral implant.

The invention provides a preparation method of an antibacterial and antioxidant TiO2-CMO composite coating triggered by near-infrared light. Firstly, a porous TiO2 substrate is formed on the surface of pure titanium through micro-arc oxidation, a spongy micro-nano layered structure is constructed through an alkali liquor hydrothermal method, and then the performance is optimized through annealing treatment. On the basis, CMO NPs nanoparticles are loaded by utilizing a polymerization reaction of chitosan oligosaccharide and ammonium molybdate, so that the layered porous TiO2-CMO composite coating is formed. The coating can kill more than 50% of adhesion bacteria at normal temperature, the antibacterial rate is increased to 98% when the coating is irradiated by near-infrared light, and meanwhile, the coating shows excellent oxidation resistance, biocompatibility and anti-inflammatory / angiogenesis promoting activity. By integrating micro-arc oxidation, hydrothermal reaction, annealing treatment and nano-particle loading technologies, multiple biological functions are successfully given to the surface of the titanium implant, and an innovative solution is provided for surface modification of orthopedic implant materials.

This invention discloses a titanium-based implant material functionalized with a piezoelectric composite coating, as well as its preparation and application. This invention constructs piezoelectric barium titanate nanopillars on the surface of an inert titanium implant through hydrothermal and alkaline heat treatment, imparting piezoelectric responsiveness to the material. A hydrogel coating is then applied in situ to the surface of the piezoelectric nanopillars through physical intercalation, creating a titanium-based implant material functionalized with a piezoelectric hydrogel coating. This material achieves mechanoelectric coupling signal regulation of vascularization and osseointegration, meeting clinical requirements.

The invention discloses a preparation method for in-situ growth of a hydroxyapatite coating on the surface of a titanium rod based on a hydrothermal method, and belongs to the technical field of biomedical materials. According to the method, by optimizing a hydrothermal reaction process, a hydroxyapatite coating with high bonding strength and excellent biological activity is formed on the surface of a titanium substrate, and the osseointegration performance of the titanium implant is remarkably improved. The process is simple and environment-friendly, and the obtained HA coating is firmly combined with the titanium substrate, has good biological activity and mechanical stability, can promote adhesion and growth of bone cells, and is suitable for long-term implantation instruments such as artificial joints and tooth root implants.

The present invention provides a surface-modified medical titanium material with antibacterial effect, a preparation method and an application thereof, and belongs to the technical field of surface modification of metal materials. The surface-modified medical titanium material of the present invention is modified on the surface of pure titanium to achieve antibacterial effect, specifically by using gold nanoparticles as a carrier to load polyhexamethylene biguanide hydrochloride, thereby obtaining a modified titanium material with both antibacterial effect and extremely low cytotoxicity. The preparation method of the surface-modified medical titanium material comprises the following steps: using piranha lotion to obtain a plurality of hydroxyl functional groups on the titanium surface, then using 3-aminopropyltrimethoxysilane for grafting and loading, and then using gold nanoparticles and polyhexamethylene biguanide hydrochloride respectively to obtain a titanium modified material loaded with gold nanoparticles and polyhexamethylene biguanide hydrochloride through electrostatic adsorption. The pure titanium modified material prepared by the present invention has a significant antibacterial effect and has no toxic effect on cells, and can effectively prevent and treat postoperative infection of titanium implants.

The application discloses a kind of micelles LYTAC engineering biomimetic titanium implants for promoting bone regeneration and its preparation method and application, belong to biomimetic medical instrument technical field.The micelles LYTAC engineering biomimetic titanium implants include titanium matrix, hydroxyapatite coating formed on the surface of the titanium matrix, and multifunctional micelles loaded in the hydroxyapatite coating;The multifunctional micelles include CLP-Apt complex, and the CLP-Apt complex is formed by covalent connection of collagen-like peptide CLP and RANK-CI-M6PR bispecific aptamer Apt through acid-sensitive linker.The application applies LYTAC technology to the surface of titanium implant by constructing HA coating loaded with CLP-Apt micelles.Experiments in vitro and in vivo show that it significantly improves the effect of bone integration under osteoporosis condition, and provides an effective scheme for long-term stability of clinical implant.

The invention relates to a container for storing and transporting a dental titanium implant, comprising a first sleeve body (2) and a second sleeve body (3), wherein the two sleeve bodies (2, 3) are each deep-drawn and designed to be combinable with each other according to a modular principle, wherein the longitudinal extent (4) of the second sleeve body (3) exceeds the longitudinal extent (4) of the first sleeve body (2) and wherein the first sleeve body (2) is at least partially received by the second sleeve body (3) and pressed together with it.

The invention relates to an ultrasonic response defect titanium oxide coating as well as a preparation method and application thereof. The ultrasonic response defect titanium oxide coating is an anoxic copper-doped titanium oxide coating positioned on the surface of the medical titanium substrate; wherein the oxygen-deficient copper-doped titanium oxide coating comprises a porous titanium oxide coating, copper ions and / or copper elementary substances uniformly distributed in the porous titanium oxide coating, and oxygen vacancies uniformly distributed in the porous titanium oxide coating. The titanium-based implant is subjected to surface modification, and transition metal ions and structural defects (such as Ti < 3 + > and oxygen vacancies) are introduced into the titanium oxide coating, so that the energy band structure of TiO2 can be adjusted, the sonodynamic treatment efficiency is improved, and the surface modified medical titanium metal material capable of resisting bacteria and promoting osteogenesis is obtained; the synchronous resistance to early-stage bacterial infection and the effective promotion of later-stage osseointegration are expected to be realized.

The present invention discloses a titanium implant surface coating that promotes bone integration and a preparation method thereof, wherein a hydrogel coating is constructed on the titanium surface by initiating free radical polymerization through ultraviolet-triggered surface catalysis. The present invention constructs a hydrogel coating on the titanium implant surface, and loads two drugs that can induce macrophages to polarize to M1 and M2 types respectively by means of swelling absorption and reversible chemical bonds, thereby achieving precise induction of the sequential M1 / M2 polarization of macrophages accumulated at the bone-titanium interface, thereby achieving the synergistic effects of antibacterial, bone tissue healing, inhibition of fibrosis and promotion of bone integration.