19 results about "Titanium implant" patented technology

The invention discloses a special-shaped titanium alloy capable of enhancing bone regeneration and repair efficacy as well as a preparation method and application of the special-shaped titanium alloy. The special-shaped titanium alloy comprises a special-shaped titanium alloy base body and a porous structure attached to the special-shaped titanium alloy base body, and the porous structure is in multi-stage size distribution and comprises long-strip-shaped gullies (100-150 micrometers wide) and large holes (30-50 micrometers wide). And the morphology in the gullies shows coralline ligaments and a nest-shaped pore channel (0.5-2 microns) structure. This can provide space and sites for the growth and adsorption of osteoblasts. According to the method, a gas phase alloying (VPA) and VPD synergistic process is adopted in a breakthrough mode, a non-oxidation / nitridation coralline-shaped hierarchical pore structure is constructed on the surface of the commercial titanium implant, and it can be achieved through verification of an aging animal model that a special-shaped matrix is uniformly modified in the whole domain, the regeneration function of aging stem cells is activated, and the bone repair and regeneration effect is effectively improved.

The application provides a preparation method of a high-efficiency piezoelectric coating on a titanium implant surface. The preparation method of the application uses a hydrothermal treatment and an in-situ piezoelectric deposition technology to in-situ synthesize a nano strontium titanate-noble metal piezoelectric coating on the titanium implant surface. The coating can generate a piezoelectric potential and active oxygen through ultrasonic driving to degrade extracellular polymers and kill bacteria. In addition, the piezoelectric coating can also promote the osteogenic differentiation of bone marrow mesenchymal stem cells under piezoelectric stimulation, and finally realize the effects of bioactivity, long-acting drug-resistant bacteria and high-efficiency bone integration in the body. The application can provide a new surface treatment technology and research idea for controlling the drug-resistant bacteria infection on the implant surface, help to break through the limitations of the existing theory and technology in removing bacterial infection on the titanium implant surface, and provide beneficial guidance for the control of bacterial biofilm on other parts and the prevention and treatment of related infectious diseases.

The application relates to a method for constructing a high-performance multi-layer coating containing hydroxyapatite on a titanium implant surface, and aims to solve the problems of poor corrosion resistance, poor antibacterial ability and poor osteogenesis ability of the existing titanium implant surface. The method comprises the following steps: one, micro-arc oxidation treatment; and two, microwave hydrothermal treatment. The application is used for constructing a high-performance multi-layer coating containing hydroxyapatite on a titanium implant surface.

This invention proposes a method for preparing dental pulp stem cell exosomes and their applications, belonging to the field of exosome technology. Dental pulp stem cells from exfoliated deciduous teeth are seeded into serum-free α-MEM medium containing microparticles, insulin-like growth factor, transforming growth factor-β1, penicillin, and streptomycin for culture. Exosomes are isolated, dispersed in PBS solution, and incubated with microparticles, propylene glycol, and rhodioloside to obtain highly active dental pulp stem cell exosomes. The surface of these exosomes is then modified with shikonin and interferon to obtain dental pulp stem cell exosomes. The dental pulp stem cell exosomes prepared by this invention exhibit good affinity for titanium implant-mediated osteointegration repair materials, demonstrating good anti-inflammatory, immunomodulatory, osteogenic, and damage-reducing effects. Furthermore, the preparation method is simple, yields high output, and operates under mild conditions, showing broad application prospects.

The invention provides a dental pulp stem cell exosome as well as a preparation method and application thereof, and belongs to the technical field of exosomes. The method comprises the following steps: inoculating exfoliated deciduous tooth pulp stem cells into a serum-free alpha-MEM culture medium containing microparticles, insulin-like growth factors, transforming growth factor-beta1, penicillin and streptomycin for culturing, separating exosomes, dispersing the exosomes into a PBS solution, adding microparticles, propylene glycol and salidroside for incubation, and separating to obtain the high-activity pulp stem cell exosomes. And performing surface modification on alkannic acid and interferon to prepare the dental pulp stem cell exosome. The dental pulp stem cell exosome prepared by the invention has relatively good affinity to a titanium implant material mediated osseointegration repair material, has relatively good advantages of resisting inflammation, regulating immunity, promoting osteogenesis, reducing injury and the like, is simple in preparation method, relatively high in yield and mild in condition, and has a wide application prospect.

The application discloses a kind of micelles LYTAC engineering biomimetic titanium implants for promoting bone regeneration and its preparation method and application, belong to biomimetic medical instrument technical field.The micelles LYTAC engineering biomimetic titanium implants include titanium matrix, hydroxyapatite coating formed on the surface of the titanium matrix, and multifunctional micelles loaded in the hydroxyapatite coating;The multifunctional micelles include CLP-Apt complex, and the CLP-Apt complex is formed by covalent connection of collagen-like peptide CLP and RANK-CI-M6PR bispecific aptamer Apt through acid-sensitive linker.The application applies LYTAC technology to the surface of titanium implant by constructing HA coating loaded with CLP-Apt micelles.Experiments in vitro and in vivo show that it significantly improves the effect of bone integration under osteoporosis condition, and provides an effective scheme for long-term stability of clinical implant.

The invention relates to an ultrasonic response defect titanium oxide coating as well as a preparation method and application thereof. The ultrasonic response defect titanium oxide coating is an anoxic copper-doped titanium oxide coating positioned on the surface of the medical titanium substrate; wherein the oxygen-deficient copper-doped titanium oxide coating comprises a porous titanium oxide coating, copper ions and / or copper elementary substances uniformly distributed in the porous titanium oxide coating, and oxygen vacancies uniformly distributed in the porous titanium oxide coating. The titanium-based implant is subjected to surface modification, and transition metal ions and structural defects (such as Ti < 3 + > and oxygen vacancies) are introduced into the titanium oxide coating, so that the energy band structure of TiO2 can be adjusted, the sonodynamic treatment efficiency is improved, and the surface modified medical titanium metal material capable of resisting bacteria and promoting osteogenesis is obtained; the synchronous resistance to early-stage bacterial infection and the effective promotion of later-stage osseointegration are expected to be realized.

The invention relates to a bimetal MOFs modified titanium implant capable of achieving dual-waveband optical response and a preparation method and application thereof. The method comprises the following steps: (1) pretreating titanium-based metal; (2) immersing the pretreated titanium-based metal substrate into a sodium hydroxide solution to obtain titanium-based metal with a sodium titanate pre-coating; and (3) the titanium-based metal with the sodium titanate pre-coating reacts with a mixed solution composed of a tetrabutyl titanate solution, a copper nitrate hexahydrate solution and a 2-aminoterephthalic acid solution, and the bi-metal MOFs modified titanium implant capable of achieving dual-waveband optical response is obtained. According to the bimetal MOFs modified titanium implant capable of achieving dual-waveband optical response, OH, O2, 1O2, H2O2 and other various active oxygen can be produced according to dual-waveband illumination as required, rapid sterilization in an operation and precise antibacterial after the operation are achieved, the occurrence rate of infectious bone defect feeling is remarkably reduced, and a programmable photocatalytic antibacterial barrier is provided for orthopedic implants.

The invention relates to the technical field of medical materials, and particularly discloses a titanium surface composite coating with osteogenesis promoting and antibacterial functions. The micro-arc magnesium oxide coating is arranged on the surface of the titanium substrate; the chitosan coating is arranged on the surface of the micro-arc magnesium oxide coating; the chlorogenic acid is loaded in the chitosan coating; a magnesium-containing porous microstructure is constructed on the surface of a titanium substrate through a micro-arc oxidation technology, so that the biological activity and corrosion resistance of the coating are improved; furthermore, chitosan is used as a biocompatible carrier to load a traditional Chinese medicine active ingredient chlorogenic acid, so that the surface of the implant has excellent osteogenic differentiation promoting capability and broad-spectrum antibacterial property at the same time. Physical modification, biopolymer drug loading and traditional Chinese medicine active ingredients are combined, and the problems that a traditional titanium implant is high in surface biological inertness, infection is likely to be caused and osseointegration is poor are solved through the synergistic effect on the three aspects of the structure, the material and the biological function.

The invention discloses a method for in-situ preparation of a metal organic network modified titanium dioxide nanotube composite coating on the surface of a titanium implant, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: firstly, forming an ordered titanium dioxide nanotube array on the surface of a titanium implant through anodic oxidation, and anchoring eight-arm polyethylene glycol of which the tail end is modified with alendronate on the surfaces of nanotubes by utilizing the strong affinity of alendronate to titanium dioxide; then, epigallocatechin gallate (EGCG), Zn < 2 + > and Ca < 2 + > are introduced, and the multifunctional metal organic network coating is formed in situ through coordination self-assembly. The obtained composite coating can synergistically release active components, has the functions of resisting oxidation, promoting angiogenesis, promoting osteogenesis and inhibiting osteoclast, and remarkably improves the osseointegration capacity of a titanium implant in an osteoporosis microenvironment. The coating provided by the invention is stable in structure and high in biological activity, is suitable for osteoporotic fracture internal fixation instruments, and has a good clinical application prospect.

The invention discloses a bioactive dental implant with a coating capable of promoting regeneration of surrounding tissues and a preparation method of the bioactive dental implant. The titanium implant of the bioactive dental implant is sequentially subjected to acid etching and alkali treatment, and the surface of the titanium implant is of a nano honeycomb network structure; the coating comprises multiple layers of biomimetic mineralized calcium phosphate coatings uniformly loaded with protein-loaded calcium phosphate nanoparticles; the protein-loaded calcium phosphate nanoparticles are loaded into the biomimetic mineralized calcium phosphate coating in a self-assembly manner in the nucleation and mineralization crystallization process of calcium phosphate. According to the invention, a multi-layer biomimetic mineralized calcium phosphate coating is constructed on the surface of the titanium implant through a biomimetic mineralization technology, protein-loaded calcium phosphate nanoparticles are uniformly assembled into the coating, the binding force between the coating and a titanium substrate is strong, and the release of protein in the protein-loaded calcium phosphate nanoparticles is matched with the regeneration stage of tissues around the implant, so that the biomimetic mineralized calcium phosphate coating has good biocompatibility. The activity loss of the active factors can be effectively avoided, the controllable release of the active factors is realized, the preparation process is simple and the cost is low.

The invention provides preparation and application of a titanium surface / implant self-assembly coating, and relates to the technical field of high polymer materials. The preparation and application of the titanium surface / implant self-assembled coating specifically comprise the following preparation steps of S1, pretreatment and modification of a titanium substrate, S2, preparation of the self-assembled coating, S3, characterization of a test piece and S4, evaluation of cytocompatibility, and the prepared finished product is applied to promotion of early osseointegration of a titanium implant in a complex implantation microenvironment. The success rate and the stability of the implant are improved. CeNPs and EGCG are modified on the surface of the titanium implant through a layer-by-layer self-assembly (LBL) technology, and the CeNPs and EGCG on the surface of the prepared implant can be slowly released along with degradation of a sandwich-shaped coating, so that the antioxidant osteogenic activity is synergistically exerted, the osseointegration demand of an organism in a complex implantation microenvironment is met, and more possibilities are provided for early-stage osseointegration of the implant.

The utility model discloses a prepared hole suite for assisting rat molar area implantation. The prepared hole suite comprises a ball drill used for positioning, a sharp drill used for direction positioning, a hole expanding drill used for hole expanding and a side cutting drill used for correcting the hole direction. Wherein a drill rod of the expanding drill is provided with a first limiting part, the sleeve piece further comprises a check ring, and the check ring can be connected with the first limiting part and used for surrounding the side portion of the expanding drill, so that the expanding drill is prevented from moving during expanding operation. The ball drill disclosed by the utility model can assist in positioning an implantation site and flattening an alveolar bone surface of the implantation site; the sharp drill can assist in guiding the implant; the expanding drills with different specifications can expand the planting cavity step by step, the operation requirements of titanium implants with different diameters are met, meanwhile, the final depth of the implant is determined, and the initial stability of the implant is guaranteed; the side cutting drill is used for cutting the alveolar bone and changing the implanting direction and position of the implant; and the stop ring can assist the positioning and depth setting of the reamed hole in the implanting process of the implant.

The invention provides a preparation method of medical titanium of a silicon dioxide and Prussian blue nano-particle composite coating with multiple biological functions and a medical titanium product obtained by the method aiming at the defects that an existing titanium implant surface modification technology is single in function and difficult to adapt to a complex pathological environment. The invention also discloses application of the medical titanium product in a diabetic rat maxilla implantation experiment.

The invention discloses a bone regeneration and repair titanium alloy with a macrophage aging adjusting effect and a preparation method and application thereof.The bone regeneration and repair titanium alloy comprises a titanium alloy matrix and a porous structure attached to the titanium alloy matrix, and the porous structure is in multi-stage size distribution and comprises long-strip-shaped gullies and large holes (50 [mu] m Cavity); the morphology in the gullies shows a coralline ligament and a nest-shaped pore channel (1 [mu] m) structure. This can provide space and sites for the growth and adsorption of osteoblasts. The invention also provides a novel method for preparing the non-oxidation and non-nitridation coralline-shaped porous structure on the commercial titanium implant through a vapor phase alloying (VPA) and vapor phase dealloying (VPD) combined method. And an effective way is provided for realizing in-vivo osseointegration and reconstruction.

The invention discloses a titanium implant with a functionalized micro-nano two-stage topological structure and a preparation method and application of the titanium implant, and belongs to the technical field of medical instruments, and the titanium implant comprises a wave-shaped micro groove and a TiO2 nanotube array grown on the surface of the wave-shaped micro groove in an overlapped mode. The preparation method of the titanium implant comprises the following steps that the wave-shaped micro-groove is etched in the titanium alloy through laser, then anodic oxidation and heat treatment are conducted, the height-ordered TiO2 nanotube array grows on the surface of the wave-shaped micro-groove in an overlapped mode, and then the titanium implant of the functionalized micro-nano two-stage topological structure is obtained. The titanium dioxide nanotubes grow on the surfaces of the micron-sized grooves in situ to form a micro-nano two-stage topological structure, the synergistic effect of mechanical adaptation and biological regulation is achieved, the mechanical stability and biological integration capacity of a prosthesis-soft tissue interface can be synchronously enhanced, and the method can be used for preparing functional implants in jaw defect repair.

The invention provides a titanium implant surface coating with photo-thermal-nano-enzyme dual effects and a preparation method and application thereof. The preparation method of the coating comprises the following steps: (1) putting a pretreated titanium implant into an alkali solution, and carrying out alkali heat treatment; and washing and drying to obtain the titanium implant with the sodium titanate pre-coating. (2) adding a titanium source, a molybdenum source and an organic ligand into a solvent, and uniformly stirring to obtain a mixed solution; putting the titanium implant with the sodium titanate pre-coating obtained in the step (1) into the mixed solution, and reacting; and after the reaction is completed, washing and drying to obtain the product. The coating provided by the invention has a unique environment-responsive two-way regulation function, solves the problem that the surface of a traditional titanium implant is difficult to give consideration to efficient antibiosis and immune microenvironment regulation, and realizes synergistic treatment of antibiosis, anti-inflammation and bone integration promotion.

This invention discloses a nanoporous titanium implant loaded with a composite coating, its construction method, and its applications. First, by precisely controlling the anodizing time, a nanoporous structure with interconnected pore walls is constructed on the surface of a titanium substrate, replacing the traditional nanotube structure with poor mechanical properties. Then, a polydopamine / strontium ion composite coating is constructed on the nanoporous surface using a one-step impregnation method. This composite coating utilizes the strong coordination between polydopamine and strontium ions to achieve efficient loading, and achieves long-term, stable, and controllable release of strontium ions through coating degradation and coordination bond breaking. The implant of this invention generates a synergistic effect between its nanotopological structure and the released strontium ions, actively inducing macrophages to polarize towards the M2 anti-inflammatory phenotype, constructing a healing-promoting immune microenvironment, thereby systematically promoting osteogenic differentiation of bone marrow mesenchymal stem cells and angiogenic function of vascular endothelial cells, ultimately achieving rapid, stable, and high-quality bone integration.

The invention discloses a micelle LYTAC engineering bionic titanium implant for promoting bone regeneration as well as a preparation method and application of the micelle LYTAC engineering bionic titanium implant, and belongs to the technical field of bionic medical instruments. The micelle LYTAC engineering bionic titanium implant comprises a titanium substrate, a hydroxyapatite coating formed on the surface of the titanium substrate, and a multifunctional micelle loaded in the hydroxyapatite coating, the multifunctional micelle comprises a CLP-Apt compound, and the CLP-Apt compound is formed by covalent linkage of a collagen-like peptide CLP and an RANK-CI-M6PR bispecific aptamer Apt through an acid sensitive connexon. According to the invention, the LYTAC technology is applied to the surface of the titanium implant by constructing the HA coating loaded with the CLP-Apt micelle. In-vivo and in-vitro experiments show that the osseointegration effect is remarkably improved under the osteoporosis condition, and an effective scheme is provided for long-term stability of clinical implants.