Preparation method of titanium implant surface with micro-nano composite structure

A technology of micro-nano composite structure and titanium implant is applied in the field of medical material manufacturing, which can solve the problem of few methods for constructing nano-scale structures, and achieve the effect of improving surface biological activity and improving protein adsorption capacity.

Active Publication Date: 2013-02-06
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many methods for endowing implant surfaces with microscale and nanoscale structures respectively, but few methods for constructing nanoscale structures on top of microscale structures

Method used

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  • Preparation method of titanium implant surface with micro-nano composite structure
  • Preparation method of titanium implant surface with micro-nano composite structure
  • Preparation method of titanium implant surface with micro-nano composite structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Sandblasting: use 40~60 mesh emery for titanium implants with a smooth surface, spray evenly for 60 seconds at a pressure of 5 bar, and wash the sprayed implants with acetone, ethanol and pure water under ultrasound for 15 minutes. , Then wash it with plenty of pure water and blow dry with nitrogen. Obtain large ups and downs ranging from ten to ten microns.

[0018] (2) Oxalic acid etching: The implants after sandblasting are directly placed in a fully dissolved oxalic acid solution with a mass concentration of 37.5% in a boiling water bath for 60 minutes, then washed with plenty of water and dried with nitrogen.

[0019] (3) Secondary acid etching: Put the above-mentioned oxalic acid-treated implants into H with a volume ratio of 1:1 2 SO 4 (Mass concentration 98%) and H 2 O 2 In the mixed solution (mass concentration 30%), treat at room temperature for 60 minutes. After the treatment, it is directly washed with a large amount of water to obtain a nano-scale undulatin...

Embodiment 2

[0021] (1) Sandblasting: Use 20-40 mesh emery for the smooth surface of the implants, spray evenly for 60 seconds at a pressure of 5 bar, and wash the sprayed implants with acetone, ethanol and pure water under ultrasound for 15 minutes. Then wash with plenty of pure water and blow dry with nitrogen. Obtain large ups and downs ranging from ten to ten microns.

[0022] (2) Oxalic acid etching: The dried implants are directly placed in a fully dissolved oxalic acid solution with a mass concentration of 37.5% in a boiling water bath for 60 minutes, and washed with a large amount of pure water.

[0023] (3) Secondary acid etching: Put the implants treated above into H with a volume ratio of 1:1 2 SO 4 (Mass concentration 98%) and H 2 O 2 In the mixed solution (mass concentration 30%), treat at room temperature for 90 minutes. After the treatment, it is directly washed with a large amount of water to obtain a nano-scale undulating structure on the original micro-hole structure, thereby...

Embodiment 3

[0025] (1) Sandblasting: Use 80-100 mesh emery for smooth surface implants, spray evenly for 60 seconds under 5 bar pressure, and clean the sprayed implants with acetone, ethanol and pure water under ultrasound for 15 minutes. Then wash with plenty of pure water and blow dry with nitrogen. Obtain large ups and downs ranging from ten to ten microns.

[0026] (2) Oxalic acid etching: The blow-dried implants are directly placed in a fully dissolved oxalic acid solution with a mass concentration of 37.5% in a boiling water bath for 30 minutes, and washed with a large amount of pure water.

[0027] (3) Secondary acid etching: Put the implants treated above into H with a volume ratio of 1:1 2 SO 4 (Mass concentration 98%) and H 2 O 2 In the mixed solution (mass concentration 30%), treat at room temperature for 90 minutes. After the treatment, it is directly washed with a large amount of water to obtain a nano-scale undulating structure on the original micro-hole structure, thereby obtai...

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Abstract

The invention provides a preparation method of a titanium implant surface with a micro-nano composite structure. The preparation method comprises the following steps: (1) performing blast sanding and ultrasonic processing on a smooth implant surface, then washing with water, and drying; (2) processing the implant surface in an oxalic acid solution for 30-240 min, then washing with water, and drying, wherein the concentration of the oxalic acid solution is 30% to saturation; and (3) taking a mixed acid solution of H2SO4 with the concentration of 98% and H2O2 with the concentration of 30% for processing, and then washing with water to obtain the titanium implant surface with the micro-nano composite structure. According to the preparation method of the titanium implant surface with the micro-nano composite structure, disclosed by the invention, the implant surface with the micro-nano composite structure is obtained by performing a secondary etching on a micron-structure surface processed by sand blast and oxalic acid, and compared to the micron-structure surface, titanium implant surface is provided with a microstructure with more levels, which is capable of providing more comprehensive environment signals for cell growth and tissue regeneration; and the titanium implant surface with the micro-nano composite structure has super-hydrophilicity and the protein adsorption capability is remarkably enhanced, which are of a great significance to further improving the surface biological activity of implants.

Description

Technical field [0001] The invention belongs to the technical field of medical material manufacturing, and describes a method for preparing the surface of a titanium implant with a micro-nano composite structure. technical background [0002] Since the theory of osseointegration was proposed in the middle of the 20th century, significant progress has been made in the research and application of implants; implant restoration is supported by artificial tooth roots without the need to remove healthy neighboring teeth, with high chewing efficiency, low foreign body sensation, and no damage. Adjacent teeth, sturdy and durable, and can achieve good aesthetic and functional restoration effects in the case of free end loss and full mouth loss that cannot be achieved by conventional fixed restorations. It is favored by the majority of patients with missing teeth and is known as "human The third tooth". Implant technology has become a conventional treatment method for the treatment of den...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23F1/16A61L27/50
Inventor 李晓东罗巧洁黄颖
Owner ZHEJIANG UNIV
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