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Antibacterial coating of magnesium-based tissue engineering material and preparation method thereof

A technology of tissue engineering and antibacterial coating, which is applied in the field of antibacterial coating of magnesium-based tissue engineering materials and its preparation, can solve the problems of reducing the corrosion rate of porous magnesium and magnesium alloys, and the inability to effectively antibacterial, so as to solve bacterial infection and excellent sterilization Anti-inflammatory properties, osteogenic and angiogenic effects

Active Publication Date: 2021-09-28
SHANGHAI INNOVATON MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention solves the problem that current porous magnesium and magnesium alloy materials cannot be effectively antibacterial, and prepares a bioactive calcium-phosphorus-loaded nano-metal (silver, zinc, copper) compound antibacterial bioactive coating on the surface of porous magnesium and magnesium alloy materials, which not only significantly reduces Improves the corrosion rate of matrix porous magnesium and magnesium alloys in body fluids (corrosion rate is reduced by 30-70%), and also improves the surface bioactivity of the matrix to promote osteogenesis and angiogenesis, and has slow-release silver ions and excellent broad-spectrum Bactericidal and anti-inflammatory properties; the operation process is simple and easy, the prepared coating has strong bonding force with the substrate, and the surface density of the nano-metal (silver, zinc, copper) compound carried on it can be adjusted

Method used

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  • Antibacterial coating of magnesium-based tissue engineering material and preparation method thereof
  • Antibacterial coating of magnesium-based tissue engineering material and preparation method thereof
  • Antibacterial coating of magnesium-based tissue engineering material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0049] Preparation of antibacterial bioactive calcium-phosphorus-loaded nano-silver compound antibacterial bioactive coating on the surface of porous pure magnesium for tissue engineering, its structure is shown in the appendix figure 1 . During preparation, the porous pure magnesium is first made into The samples were ultrasonically cleaned with absolute ethanol and acetone for 5 min, respectively, and dried. Put the sample into CaHPO 4 :NaOH=8:2(wt.%) Soak in a water bath at a constant temperature (20°C) for 48h, take it out, wash it twice with ultrapure water, and blow dry. Immerse the porous pure magnesium sample coated with calcium phosphorus coating in 0.1mM silver chlorate solution to avoid light for 6 hours, take it out, wash it twice with ultrapure water, and dry it to get the antibacterial bioactive calcium Phosphorus loaded nano-silver compound coating. The scanning electron microscope observed that the thickness of the Ca-P coating was about 50 μm, and the ato...

Embodiment 2

[0051] Preparation of bioactive calcium phosphorus-supported nano-copper compound antibacterial bioactive coating on the surface of porous AZ31 (Mg-Al system) alloy. First, the porous AZ31 magnesium alloy is made into The samples were ultrasonically cleaned with absolute ethanol and acetone for 10 min, respectively, and dried. Put the sample into Ca(H 2 PO 4 ) 2 : NaOH=9:1 (wt.%) solution soaked at 25 ℃ for 10h, after taking out, washed twice with ultrapure water, and dried to obtain calcium phosphorus coating. Immerse the porous AZ31 alloy sample coated with calcium phosphorus coating in 0.8mM copper nitrate solution to avoid light and ultrasonic reaction for 3 hours, take it out, wash it twice with ultrapure water, and dry it to get the antibacterial bioactive calcium Phosphorus-loaded nano-copper compound coating. The scanning electron microscope observed that the thickness of the Ca-P coating was about 20 μm, and the atomic ratio of Ca / P was 1:1. The nano-copper comp...

Embodiment 3

[0053] Preparation of bioactive calcium-phosphorus-supported nano-zinc compound coating for antibacterial on the surface of porous Mg-Nd-Zn-Zr alloy. The porous Mg-Nd-Zn-Zr magnesium alloy is made into The samples were ultrasonically cleaned with absolute ethanol and acetone for 10 min, respectively, and dried. The sample was soaked in a 20% HF solution in a water bath at a constant temperature (20°C) for 8 hours, washed with deionized water and absolute ethanol successively, and dried. The fluorinated sample was then placed in Ca(NO 3 ) 2 :(NH 4 ) 2 HPO 4 =6.2:3.8 (wt.%) soaked in the solution of 4 ℃ for 6h, washed twice with ultrapure water after taking out, and dried to obtain a bioactive calcium-phosphorus composite coating. Immerse the porous Mg-Nd-Zn-Zr alloy coated with calcium-phosphorus coating in 5.0mM zinc nitrate solution to avoid light and shake for 10 minutes, take it out, wash it twice with ultrapure water, and dry it to get the Antibacterial bioactive c...

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Abstract

The invention discloses a magnesium-based tissue engineering material antibacterial coating and a preparation method thereof. The coating includes a bioactive calcium-phosphorus coating and a nano-metal compound antibacterial coating on the surface of the porous magnesium and magnesium alloy materials from the inside to the outside; during preparation, the porous magnesium-based material is placed in a solution containing calcium phosphate salt Soaking, chemically depositing a bioactive calcium-phosphorus coating; then placing the porous magnesium-based material deposited on the calcium-phosphorus layer in a constant temperature and dynamic immersion reaction in a metal compound solution, and preparing the above-mentioned nanometer metal compound antibacterial coating on the surface of the outer layer of calcium-phosphorus layer, namely have to. The coating prepared by the invention not only significantly reduces the corrosion rate of the matrix porous magnesium and magnesium alloy, but also improves the surface biological activity of the matrix, can promote osteogenesis and angiogenesis, and has high-efficiency broad-spectrum antibacterial effect. The operation process is simple and easy, the prepared coating has strong binding force with the substrate, and the surface density and particle size of the nanometer metal compound carried can be adjusted.

Description

technical field [0001] The invention relates to a magnesium-based tissue engineering material antibacterial coating and a preparation method thereof, belonging to the technical field of preparation of biomedical materials. Background technique [0002] In the field of orthopedic implants, magnesium and magnesium alloys are expected to replace stainless steel, titanium and titanium alloys in traditional medicine due to their unique biodegradability, biocompatibility and Young's modulus similar to human bone. Internal implant materials are considered to be "revolutionary medical implant materials" in the field of orthopedics. Porous magnesium and magnesium alloy materials with a three-dimensional through-hole structure not only play a role in tissue filling at the implant site, but also promote the growth of blood vessels and surrounding tissues. In the process of repairing or shaping the implant site It is gradually degraded and absorbed to achieve the effect of self-repair....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/32A61L27/04A61L27/30A61L27/54A61L27/56A61L27/58
CPCA61L27/047A61L27/306A61L27/32A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/104A61L2300/404A61L2300/41A61L2300/412A61L2300/604A61L2300/608A61L2420/08
Inventor 裴佳张磊袁广银
Owner SHANGHAI INNOVATON MEDICAL TECH CO LTD
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