162results about How to "Promote osteogenesis" patented technology

In an aspect the invention is a method of preparing a cell or tissue implant for insertion into a patient in need of treatment by obtaining a transplantable cell population, culturing the cell population in a culture media and exposing the cell population to a sonic or ultrasonic stimulation, wherein the stimulation provides a capability for an enhanced implant outcome parameter. The method provides enhanced autologous bone implant procedures by reducing the time required for a patient's own cells to sufficiently undergo osteogenesis, thereby reducing the waiting time for an autologous bone implant. The extent of osteogenesis is optionally monitored non-invasively by magnetic resonance spectroscopy.

Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.

The invention relates to a medical degradable and absorbable Mg-Sr system magnesium alloy implant and a preparation method thereof. The medical implant is made of Mg-Sr system alloy, and the Mg-Sr system alloy comprises the following elements in percentage by weight: 0 to 5 percent of strontium (except for 0 percent), a small amount of trace elements, namely one or more of manganese, zirconium, stannum, rare earth and yttrium and the balance of magnesium, wherein the total content of the trace elements is less than 3 percent. In-vivo and in-vitro experiments prove that the Mg-Sr system magnesium alloy implant does not have toxicity, has high histocompatibility, and is a reliable biological medical implant material.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the over-all osteogenic activity of rgBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.

The invention relates to a modification method for a titanium surface with osteogenic performance and antibacterial performance. The modification method adopts a plasma-immersion ion implantation treatment process to co-implant silver ion and calcium ion to the surface of a titanium base material, wherein the co-implantation simultaneously arouse two cathode impulse arc sources, which respectively adopt pure silver and pure calcium as a cathode, to carry out plasma-immersion ion implantation treatment process. The silver-calcium co-implantation method provided by the invention can be used for improving the osteogenic performance and antibacterial performance of the surface (for example an artificial bone, an artificial joint and a dental implant) which can be implanted to medical equipment. The prepared modified material has a remarkable inhibitory effect to the escherichia coli and staphylococcus aureus, and a remarkable promotion to adhesion and proliferation of relevant osteoblast (BMSCs, MG63 cells).

The invention discloses a bioactive porous ceramic tubular bar material as well as a preparation method and application thereof. The bioactive porous ceramic tubular bar material comprises a non-biodegradable calcium magnesium silicate porous ceramic tube and a biodegradable calcium magnesium silicate modified layer, wherein the biodegradable calcium magnesium silicate modified layer is modified by calcium magnesium silicate, subjected to sintering treatment and then cover the pore channel wall of the porous ceramic tube. The preparation method comprises the following steps: performing mixing treatment on tetraethoxysilane, calcium salt, magnesium salt, nitric acid and trace element inorganic salt or acid to obtain hydrogel; putting the pre-built calcium magnesium silicate porous ceramic tube into the hydrogel, dipping, sucking, ageing, drying, calcining and cooling to obtain the bioactive porous ceramic tubular bar material. The tubular bar material provided by the invention can decompress a femoral head necrosis medullary core for a long time, can significantly improve vascularization and nutrient transmission of a necrotic area and can promote new bone regeneration of bone injury; the tubular bar material has excellent bioactivity and has application value in femoral head necrosis and defected bone remodeling of a large bone.

The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and/or following bone distraction comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to at least one site of bone distraction.

The present invention relates to a method capable of utilizing internal perfusion to induce bone marrow matrix stem cell to construct tissue engineering bone. Said method includes the following steps: (1), extraction, separation and culture of bone marrow matrix stem cell; (2), preparation of coral composite artificial bone; and (3), creation of perfusion system.

The invention discloses a Zn-Li-Mg-system zinc alloy and a preparation method and application thereof. The zinc alloy comprises, by weight, 0-1% of Li, 0-1% of Mg and the balance Zn, wherein the masspercents of Li and Mg are not zero. The zinc alloy prepared by the preparation method is excellent in mechanical performance, can provide long-term and effective supporting force in a body, has excellent cellular and blood compatibility, and can be applied to preparation of biomedical implants.

The invention discloses a mesoporous bioactive glass/metal organic framework support material and a preparation method of the material. The preparation method comprises the steps of preparing mesoporous bioactive glass/metal organic framework composite printing ink, designing an appearance and an internal structure of the support material via CAD/CAM (computer aided design/computer aided manufacturing) computer aided software, and preparing the mesoporous bioactive glass/metal organic framework composite support material via a low temperature 3D (three dimensional) printing technology. The prepared mesoporous bioactive glass/metal organic framework composite support material has a three-dimensional communicating and controllable macroporous structure, is high in mechanical strength and good in biocompatibility, can promote proliferation, differentiation and osteogenesis of bone marrow mesenchym stem cells of a human body and is expected to provide a new strategy for repairing treatmentof a large segmental bone defect clinically.

The present invention provides a composite material for enhancing or inducing osteogenesis in a biological organism, comprising A) a chondrocyte having the potential for hypertrophy, and B) a scaffold that is biocompatible with the biological organism. The present invention also provides a method for producing a composite material for enhancing or inducing osteogenesis in a biological organism, comprising A) providing a collected chondrocyte having the potential for hypertrophy, and B) culturing the chondrocyte having the potential for hypertrophy on a scaffold that is biocompatible with the biological organism.

The invention relates to a novel vascularized tissue-engineered bone which comprises a cylinder support material, two internal axially-preset circular tunnels and arteriovenous blood vessel peduncles. The cylinder support material is a medical absorbable material, the two internal axially-preset circular tunnels are parallel to each other, an outlet circular chamfer is arranged at an outlet, and human or animal osteogenic induction stem cells are evenly distributed inside the circular tunnels. The arteriovenous blood vessel peduncles comprise arteries, veins and arteriovenous grafts, the arteries, the veins and the arteriovenous grafts are arranged on receptor blood vessel peduncles, the arteriovenous blood vessel peduncles are arranged in the support material and are arranged in parallel in a separated mode, and distal blood vessels are anastomosed or ligatured. According to the novel vascularized tissue-engineered bone, the tissue-engineered bone can be vascularized fast, fully, safely and effectively after transplantation, the clinical effects are effectively improved, good nutrition supply and the good metabolism environment are provided for transplanted cells, the osteogenic activity of the tissue-engineered bone after transplantation is promoted, and the wide clinical application of the grafts of the tissue-engineered bone is promoted.

The invention relates to a biological ceramic scaffold with a surface micro-nano structure and a preparation method and application of the biological ceramic scaffold with the surface micro-nano structure. The biological ceramic scaffold with the surface micro-nano structure comprises a Ca7Si2P2O16 biological ceramic scaffold body and a micro-nano structured polydopamine/Ca-P nano layer formed on the surface of the Ca7Si2P2O16 biological ceramic scaffold body. By means of forming the micro-nano structured polydopamine/Ca-P nano layer on the surface of the Ca7Si2P2O16 biological ceramic scaffold body, adhesion, proliferation and differentiation of bone mesenchymal stem cells on the surface of the scaffold can be facilitated to promote in-vivo osteogenesis, and therefore the biological ceramic scaffold (or dopamine-induced biological ceramic scaffold) with the surface micro-nano structure prepared herein can repair bones and treat bone tumors.

The invention provides a method for preparing an Ag/ZnO/HA nanocomposite coating on a titanium alloy. Firstly, a chemical reduction method is used for preparing nanosilver grains with an excellent antibacterial property, a laser cladding technique is used for preparing the firm Ag/ZnO/HA nanocomposite coating, Ag has an excellent anti-bacterial property, ZnO has a certain anti-bacterial property and an osteogenesis property, HA has excellent biocompatibility and an osteogenesis property, each component in the coating performs the corresponding function and realizes the effects of coordinated sterilization and biocompatibility, and the improved titanium alloy with the coating has a lasting anti-bacterial property and good biocompatibility.

The invention relates to a preparation method of a zinc-doped hydroxyapatite coating used for a magnesium alloy material. The method comprises the following steps of (1) pretreatment of a magnesium alloy matrix, specifically, after being cut and ground, the magnesium alloy matrix is washed to be clean; (2) preparation of hydrothermal solution, specifically, a calcium source, a phosphorus source and a zinc source are added into water, the pH value is regulated to be 9-11, and the hydrothermal solution is obtained; and (3) preparation of the coating, specifically, the magnesium alloy matrix after pretreatment is placed a hydrothermal reactor containing the hydrothermal solution, the hydrothermal reaction is conducted, and the zinc-doped hydroxyapatite coating wrapping the magnesium alloy matrix is obtained. Compared with the prior art, the preparation method adopts a hydrothermal method to prepare the zinc-doped modified hydroxyapatite coating on the surface of a magnesium alloy, the coating is uniform and compact, combining of the coating and the matrix is good, the thickness of a film layer is considerable, and the biocompatibility of the magnesium alloy is further improved while the corrosion resistance of the magnesium alloy is improved effectively.