166results about How to "Promote osteogenesis" patented technology

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, perdiodontitis, and oral malodor while also promoting general oral hygiene.

A spine implant system having two or more adjacent segments that have a male-female annular interlocking relationship for increased mechanical stability and resistance to relative translation and rotation. One or more segments is provided with at least one perforation channel or void to promote osteo-induction within the segment. Optionally, two adjacent segments have at least one common or aligned perforation channel or void. Two or more spaced apart portions of a segment surface are optionally chamfered to provide easier fabrication and / or positioning of the segment. Two spaced apart exposed surface planes of an interlocked segment pair optionally are axially oriented at a small positive angle relative to each other, to approximate natural spine curvature. Segments in some embodiments have a curvilinear delta cross sectional shape and / or have crosshatched grooves in exposed surfaces. Many of the embodiments are useful in transforaminal lumbar interbody fusion (TLIF).

In an aspect the invention is a method of preparing a cell or tissue implant for insertion into a patient in need of treatment by obtaining a transplantable cell population, culturing the cell population in a culture media and exposing the cell population to a sonic or ultrasonic stimulation, wherein the stimulation provides a capability for an enhanced implant outcome parameter. The method provides enhanced autologous bone implant procedures by reducing the time required for a patient's own cells to sufficiently undergo osteogenesis, thereby reducing the waiting time for an autologous bone implant. The extent of osteogenesis is optionally monitored non-invasively by magnetic resonance spectroscopy.

Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.

Cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making and using the same. Particularly advantageous uses include treating infections in patient and sub-patient populations, especially those having a bone disease, a broken bone, a bone infection, or a bone implant.

The invention relates to a medical degradable and absorbable Mg-Sr system magnesium alloy implant and a preparation method thereof. The medical implant is made of Mg-Sr system alloy, and the Mg-Sr system alloy comprises the following elements in percentage by weight: 0 to 5 percent of strontium (except for 0 percent), a small amount of trace elements, namely one or more of manganese, zirconium, stannum, rare earth and yttrium and the balance of magnesium, wherein the total content of the trace elements is less than 3 percent. In-vivo and in-vitro experiments prove that the Mg-Sr system magnesium alloy implant does not have toxicity, has high histocompatibility, and is a reliable biological medical implant material.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing electricity are provided for non-human animals. Electrodes are used to deliver an electrical current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and / or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and / or its digestion product.

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the over-all osteogenic activity of rgBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.

The invention relates to a modification method for a titanium surface with osteogenic performance and antibacterial performance. The modification method adopts a plasma-immersion ion implantation treatment process to co-implant silver ion and calcium ion to the surface of a titanium base material, wherein the co-implantation simultaneously arouse two cathode impulse arc sources, which respectively adopt pure silver and pure calcium as a cathode, to carry out plasma-immersion ion implantation treatment process. The silver-calcium co-implantation method provided by the invention can be used for improving the osteogenic performance and antibacterial performance of the surface (for example an artificial bone, an artificial joint and a dental implant) which can be implanted to medical equipment. The prepared modified material has a remarkable inhibitory effect to the escherichia coli and staphylococcus aureus, and a remarkable promotion to adhesion and proliferation of relevant osteoblast (BMSCs, MG63 cells).

The invention discloses a preparation method of calcium phosphate bone cement simultaneously releasing zinc ions and silicate ions. The preparation method comprises the following steps that (1) calcium phosphate bone cement powder, inorganic salt containing zinc ions and inorganic salt containing silicate ions are mixed evenly to obtain the calcium phosphate bone cement containing zinc and silicon elements, namely a solid phase; (2) the solid phase cement obtained through the step (1) and a liquid phase are blended, wherein the mass ratio of the liquid phase volume to the solid phase powder is 0.3-0.6 mL / g. The zinc ions and the silicate ions are simultaneously added into the calcium phosphate bone cement for the first time, the calcium phosphate bone cement has the advantages of having high mechanical strength and appropriate setting time and being capable of continuously releasing the zinc ions and silicate ions for a long time and controllable in release amount, and meanwhile the two different types of released functional ions can play roles of synergistically inhibiting bone absorption and promoting bone repair. Compared with traditional calcium phosphate bone cement, the calcium phosphate bone cement has more excellent bone defect repairing effect and wider clinical application prospect.

The invention discloses a bioactive porous ceramic tubular bar material as well as a preparation method and application thereof. The bioactive porous ceramic tubular bar material comprises a non-biodegradable calcium magnesium silicate porous ceramic tube and a biodegradable calcium magnesium silicate modified layer, wherein the biodegradable calcium magnesium silicate modified layer is modified by calcium magnesium silicate, subjected to sintering treatment and then cover the pore channel wall of the porous ceramic tube. The preparation method comprises the following steps: performing mixing treatment on tetraethoxysilane, calcium salt, magnesium salt, nitric acid and trace element inorganic salt or acid to obtain hydrogel; putting the pre-built calcium magnesium silicate porous ceramic tube into the hydrogel, dipping, sucking, ageing, drying, calcining and cooling to obtain the bioactive porous ceramic tubular bar material. The tubular bar material provided by the invention can decompress a femoral head necrosis medullary core for a long time, can significantly improve vascularization and nutrient transmission of a necrotic area and can promote new bone regeneration of bone injury; the tubular bar material has excellent bioactivity and has application value in femoral head necrosis and defected bone remodeling of a large bone.

The present invention relates to compositions and methods for use in osteodistraction procedures. In one embodiment, a method of stimulating osteogenesis during and / or following bone distraction comprises providing a composition comprising a PDGF solution disposed in a biocompatible matrix and applying the composition to at least one site of bone distraction.

The present invention relates to a method capable of utilizing internal perfusion to induce bone marrow matrix stem cell to construct tissue engineering bone. Said method includes the following steps: (1), extraction, separation and culture of bone marrow matrix stem cell; (2), preparation of coral composite artificial bone; and (3), creation of perfusion system.

The invention discloses a Zn-Li-Mg-system zinc alloy and a preparation method and application thereof. The zinc alloy comprises, by weight, 0-1% of Li, 0-1% of Mg and the balance Zn, wherein the masspercents of Li and Mg are not zero. The zinc alloy prepared by the preparation method is excellent in mechanical performance, can provide long-term and effective supporting force in a body, has excellent cellular and blood compatibility, and can be applied to preparation of biomedical implants.

The invention provides a built-in instrument for preventing from osteonecrosis and collapse of the femoral head, and particularly discloses a built-in device which can be implanted into the femoral head to prevent from osteonecrosis of the femoral head and preventing the femoral head from early collapsing after a core compression. The build-in device mainly comprises a nickel-titanium shape memory alloy umbrella, a TA2 pure titanium supporting device body, and TA2 pure titanium tail fastening screws, wherein the nickel-titanium shape memory alloy umbrella is arranged at one end of the supporting device body, and the other end of the supporting device body is jointly inserted to the tail fastening screw; the nickel-titanium shape memory alloy umbrella comprises eight supporting belts, and is structured as a semispherical umbrella shape; the nickel-titanium shape memory alloy umbrella is controlled through the phase-transition temperature after being expanded; the supporting device body has a titanium mesh structure which can contain bone materials or growth factors; and the tail fastening screw has the function of guiding and self-tapping, which is capable of fixing the supporting device and transmitting the stress. The supporting device has the characteristics that the nickel-titanium shape memory alloy umbrella is arranged; after being implanted into a small-aperture core compression bone tunnel, the nickel-titanium shape memory alloy umbrella can be automatically expanded to increase the supporting area and adapt to the defect of endoskeleton of the femoral head; with adoption of the titanium mesh structure, the bone ingrowth can be increased. By adopting the supporting device, the femoral head can be effectively prevented from osteonecrosis and collapse after the core compression.

The invention relates to a method for preparing a dual-factor carrying type hybrid bionic bone scaffold and application of the dual-factor carrying type hybrid bionic bone scaffold. The preparation method comprises the following steps: immersing a calcium- silicon hybrid bionic bone scaffold in fibers in a chemotactic factor-osteogenesis inducing protein mixed solution with proper concentration; treating under a proper condition to obtain the dual-factor carrying type hybrid bionic bone scaffold. The related application is application of the scaffold material in a bone defect repairing material. The hybrid ossein contains silicon dioxide and hydroxyapatite two minerals, wherein due to the effective combination of massive negative charge-loaded silanol groups existing on the surface of the silicon dioxide and active hydroxyl radicals on basic protein such as SDF-1 or TGF-beta and the specifically strong adsorptivity of nano-hydroxyapatite on osteogenesis induced protein, such as BMP-2 or BMP-7, an extra sustained-release system need not to be added, and hybrid osteocyte recruitment / osteogenesis induction double functionalized modification can be realized.

The invention relates to a drug-loading sustained-release support composite body for treating infectious bone defect. The drug-loading sustained-release support composite body is prepared by the stepthat vancomycin is encapsulated by polylactic acid-glycolic acid copolymer to prepare sustained release microspheres and loaded to a beta-tricalcium phosphate support. The vancomycin, with broad-spectrum antibacterial capacity, is encapsulated by the polylactic acid-glycolic acid copolymer to prepare into sustained microspheres, and loaded to the beta-tricalcium phosphate support to prepare a novel drug-loading sustained-release anti-infection bone substitute material which can slowly release the vancomycin at a part of the infectious bone defect. When being applied to treating the infectiousbone defect, the material can release the encapsulated vancomycin in an all-dimensional mode for a long time in a partial three-dimensional space of the infectious bone defect after being embedded; thus, the purpose of controlling infection within the focus of infection is achieved; meanwhile, the effects of filling bone defect, promoting bone formation and quickening bone reconstruction are achieved.

The invention discloses a mesoporous bioactive glass / metal organic framework support material and a preparation method of the material. The preparation method comprises the steps of preparing mesoporous bioactive glass / metal organic framework composite printing ink, designing an appearance and an internal structure of the support material via CAD / CAM (computer aided design / computer aided manufacturing) computer aided software, and preparing the mesoporous bioactive glass / metal organic framework composite support material via a low temperature 3D (three dimensional) printing technology. The prepared mesoporous bioactive glass / metal organic framework composite support material has a three-dimensional communicating and controllable macroporous structure, is high in mechanical strength and good in biocompatibility, can promote proliferation, differentiation and osteogenesis of bone marrow mesenchym stem cells of a human body and is expected to provide a new strategy for repairing treatmentof a large segmental bone defect clinically.

The invention provides a miRNA (micro Ribonucleic Acid) marker and a kit related to postmenopausal osteoporosis and particularly relates to application of a miR-338 cluster as a postmenopausal osteoporosis marker. According to the invention, high expression of the miR-338 cluster such as miR-338-3p and / or miR-3065-5p in postmenopausal osteoporosis patients is found; the miR-338 cluster can be used as a marker for the postmenopausal osteoporosis and is used for preparing an auxiliary diagnosis kit for the postmenopausal osteoporosis; the auxiliary diagnosis kit can be used for specifically detecting the expression quantity of the miR-338 cluster in tissues and is early and effectively used for early auxiliary diagnosis of clinical postmenopausal osteoporosis without noninvasive. Besides, an inhibitor of the miR-338 cluster has the efficacy of promoting osteogenesis, so that the postmenopausal osteoporosis is effectively treated or prevented.

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.

The present invention provides a composite material for enhancing or inducing osteogenesis in a biological organism, comprising A) a chondrocyte having the potential for hypertrophy, and B) a scaffold that is biocompatible with the biological organism. The present invention also provides a method for producing a composite material for enhancing or inducing osteogenesis in a biological organism, comprising A) providing a collected chondrocyte having the potential for hypertrophy, and B) culturing the chondrocyte having the potential for hypertrophy on a scaffold that is biocompatible with the biological organism.

The invention relates to a novel vascularized tissue-engineered bone which comprises a cylinder support material, two internal axially-preset circular tunnels and arteriovenous blood vessel peduncles. The cylinder support material is a medical absorbable material, the two internal axially-preset circular tunnels are parallel to each other, an outlet circular chamfer is arranged at an outlet, and human or animal osteogenic induction stem cells are evenly distributed inside the circular tunnels. The arteriovenous blood vessel peduncles comprise arteries, veins and arteriovenous grafts, the arteries, the veins and the arteriovenous grafts are arranged on receptor blood vessel peduncles, the arteriovenous blood vessel peduncles are arranged in the support material and are arranged in parallel in a separated mode, and distal blood vessels are anastomosed or ligatured. According to the novel vascularized tissue-engineered bone, the tissue-engineered bone can be vascularized fast, fully, safely and effectively after transplantation, the clinical effects are effectively improved, good nutrition supply and the good metabolism environment are provided for transplanted cells, the osteogenic activity of the tissue-engineered bone after transplantation is promoted, and the wide clinical application of the grafts of the tissue-engineered bone is promoted.

The invention relates to a biological ceramic scaffold with a surface micro-nano structure and a preparation method and application of the biological ceramic scaffold with the surface micro-nano structure. The biological ceramic scaffold with the surface micro-nano structure comprises a Ca7Si2P2O16 biological ceramic scaffold body and a micro-nano structured polydopamine / Ca-P nano layer formed on the surface of the Ca7Si2P2O16 biological ceramic scaffold body. By means of forming the micro-nano structured polydopamine / Ca-P nano layer on the surface of the Ca7Si2P2O16 biological ceramic scaffold body, adhesion, proliferation and differentiation of bone mesenchymal stem cells on the surface of the scaffold can be facilitated to promote in-vivo osteogenesis, and therefore the biological ceramic scaffold (or dopamine-induced biological ceramic scaffold) with the surface micro-nano structure prepared herein can repair bones and treat bone tumors.

The invention belongs to the field of cartilage tissue repair and tissue engineering and provides a tissue engineered bone cartilage frame and a preparation method thereof. Particularly, marrow removal and degreasing are carried out on allogeneic or xenogeneic cancellous bones to obtain cancellous bone columns with experimentally or clinically required diameters, and then a tissue engineered bonecartilage frame with a completely decalcified upper layer and a superficially decalcified lower layer is obtained via layered decalcification. The upper layer of the frame is used as the framework part of the tissue engineered cartilage frame or an engineering cartilage frame, and the lower layer thereof can be used as a bone forming frame, an engineering bone bracket and the fixed pivot of the engineered cartilage, and can be used for constructing an integrative tissue engineered bone cartilage or directly transplanted for the cartilage or bone cartilage repair. Compared with the existing tissue engineered bone cartilage frame, the invention has the advantages of integration (no interface mechanical defect), and good compatibility of a pore structure and the tissue, has better compression resisting, tensile resisting and shear resisting properties, and is convenient for the minimally invasive surgery operation under an arthroscope.

The invention provides a method for preparing an Ag / ZnO / HA nanocomposite coating on a titanium alloy. Firstly, a chemical reduction method is used for preparing nanosilver grains with an excellent antibacterial property, a laser cladding technique is used for preparing the firm Ag / ZnO / HA nanocomposite coating, Ag has an excellent anti-bacterial property, ZnO has a certain anti-bacterial property and an osteogenesis property, HA has excellent biocompatibility and an osteogenesis property, each component in the coating performs the corresponding function and realizes the effects of coordinated sterilization and biocompatibility, and the improved titanium alloy with the coating has a lasting anti-bacterial property and good biocompatibility.