Drug-loading sustained-release support composite body for treating infectious bone defect

Abstract

The invention relates to a drug-loading sustained-release support composite body for treating infectious bone defect. The drug-loading sustained-release support composite body is prepared by the stepthat vancomycin is encapsulated by polylactic acid-glycolic acid copolymer to prepare sustained release microspheres and loaded to a beta-tricalcium phosphate support. The vancomycin, with broad-spectrum antibacterial capacity, is encapsulated by the polylactic acid-glycolic acid copolymer to prepare into sustained microspheres, and loaded to the beta-tricalcium phosphate support to prepare a novel drug-loading sustained-release anti-infection bone substitute material which can slowly release the vancomycin at a part of the infectious bone defect. When being applied to treating the infectiousbone defect, the material can release the encapsulated vancomycin in an all-dimensional mode for a long time in a partial three-dimensional space of the infectious bone defect after being embedded; thus, the purpose of controlling infection within the focus of infection is achieved; meanwhile, the effects of filling bone defect, promoting bone formation and quickening bone reconstruction are achieved.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a drug-loaded sustained-release stent complex for treating infectious bone defects. Background technique [0002] In the treatment of infected bone defects, simple bone grafting is likely to fail due to uncontrolled infection. Therefore, patients often cannot undergo primary bone grafting, but complete debridement is required. The secondary stage is performed after the infection is eliminated, the wound is healed, and the blood supply is revascularized. Bone grafting to repair bone defects has the disadvantages of long treatment period, high medical expenses, and great pain for patients. [0003] The slow-release system loaded with antibiotics studied in recent years can effectively control infection, but because it does not promote osteogenesis, delayed bone healing or nonunion still occurs from time to time. If an osteoinductive slow-release scaffold material that can effecti...

AI Technical Summary

Problems solved by technology

[0002] In the treatment of infected bone defects, simple bone grafting is likely to fail due to uncontrolled infection. Therefore, patients often cannot undergo primary bone grafting, but complete debridement is required. The secondary stage is performed after the infection is eliminated, the wound is healed, and the blood supply is revascularized. Bone grafting to repair bone defects has the disadvantages of long treatment period, high medical expenses, and great pain for patients

[0003] The antibiotic-loaded slow-release system studied in recent years can effectively control infection, but because it does not promote osteogenesis, delayed bone healing or nonunion still occurs from time to time