A drug-loaded slow-release scaffold complex for treating infectious bone defects

Abstract

The invention relates to a drug-loaded sustained-release scaffold complex for treating infectious bone defects. The sustained-release microspheres are made by encapsulating vancomycin with poly(lactic-co-glycolic acid) copolymer and loaded on β-tricalcium phosphate The bracket is made. In the present invention, vancomycin with broad-spectrum antibacterial ability is encapsulated with polylactic acid-glycolic acid copolymer to make sustained-release microspheres, and loaded on β-tricalcium phosphate scaffolds to prepare a kind of microspheres that can treat local infected bone defects. A new drug-loaded slow-release anti-infective bone substitute material that slowly releases vancomycin is applied to the treatment of infected bone defects, so that after the material is implanted, it can be used in all directions and for a long time in the local three-dimensional space of infected bone defects. The encapsulated vancomycin can be released efficiently to achieve the purpose of controlling infection in the lesion. At the same time, it can also fill bone defects, promote osteogenesis, and accelerate bone reconstruction.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a drug-loaded sustained-release stent complex for treating infectious bone defects. Background technique [0002] In the treatment of infected bone defects, simple bone grafting is likely to fail due to uncontrolled infection. Therefore, patients often cannot undergo primary bone grafting, but complete debridement is required. The secondary stage is performed after the infection is eliminated, the wound is healed, and the blood supply is revascularized. Bone grafting to repair bone defects has the disadvantages of long treatment period, high medical expenses, and great pain for patients. [0003] The slow-release system loaded with antibiotics studied in recent years can effectively control infection, but because it does not promote osteogenesis, delayed bone healing or nonunion still occurs from time to time. If an osteoinductive slow-release scaffold material that can effecti...

AI Technical Summary

Problems solved by technology

[0002] In the treatment of infected bone defects, simple bone grafting is likely to fail due to uncontrolled infection. Therefore, patients often cannot undergo primary bone grafting, but complete debridement is required. The secondary stage is performed after the infection is eliminated, the wound is healed, and the blood supply is revascularized. Bone grafting to repair bone defects has the disadvantages of long treatment period, high medical expenses, and great pain for patients

[0003] The antibiotic-loaded slow-release system studied in recent years can effectively control infection, but because it does not promote osteogenesis, delayed bone healing or nonunion still occurs from time to time