83 results about "Glycollic acid" patented technology

The invention provides a high-hydrophobicity anti-pollution flashover coating and a preparation method thereof, and relates to the field of coatings. The silicone rubber composition is prepared from the following raw materials in parts by weight: 80 to 100 parts of hydroxyl-terminated polydimethylsiloxane; 5 to 15 parts of modified nano silicon dioxide; 10 to 30 parts of a composite self-repairing microcapsule; 10 to 25 parts of a flame retardant; 3-8 parts of a cross-linking agent; 0.5-2 parts of a catalyst; 1-5 parts of an accelerant; 40 to 100 parts of a solvent; the modified nano silicon dioxide is fumed silica subjected to surface treatment by a fluorine-containing silane coupling agent and a platinum catalyst; the capsule wall of the composite self-repairing microcapsule is a polylactic acid-glycolic acid copolymer, and the capsule core of the composite self-repairing microcapsule is a mixed solution of a hydroxyl-terminated polydimethylsiloxane oligomer and methyltris (methylethylketoximino) silane. The coating has excellent hydrophobicity, weather resistance and targeted repair function.

The invention discloses a liquid chromatography determination method for a mixed solution of glyoxylic acid, glycollic acid and oxalic acid and application. The method comprises the following steps: (1) preparing standard solutions with different concentrations; (2) detecting the standard solutions with different concentrations by using high performance liquid chromatography; (3) establishing a linear regression equation of each acid according to the relationship between the concentration of the standard solution and the corresponding peak area; (4) pre-treating a sample to be detected, detecting under the same condition as that in the step (2) by using high performance liquid chromatography, and recording the peak area of each acid in the sample to be detected; and (5) substituting the peak area of each acid in the to-be-detected sample into the corresponding linear regression equation, and calculating to obtain the concentrations of glyoxylic acid, glycollic acid and oxalic acid in the to-be-detected sample. The method is a liquid chromatographic determination method which is simple and convenient to operate, excellent in separation effect, mild in chromatographic condition and compatible with various detectors, can accurately quantify three strong-polarity mixed acids of glyoxylic acid, glycollic acid and oxalic acid, and has important practical application value.

The invention relates to a multilayer packaging material with high barrier property and application thereof. The multi-layer packaging material at least comprises three layers, namely a layer A, a layer B and a layer C, wherein the layer B is located between the layer A and the layer C; the layer A is prepared from the following raw materials: first biodegradable polyurethane and a cellulose nanocrystal graft which is obtained by performing grafting treatment on cellulose nanocrystal after hydrophobic modification, and the content of the cellulose nanocrystal graft is 1wt%-10wt% of that of the first biodegradable polyurethane; the raw material of the layer B comprises biodegradable polyester containing a glycollic acid structural unit, and the content of the glycollic acid structural unit is not less than 60% mol; the raw material of the layer C comprises second biodegradable polyurethane. The hydrophobic modified cellulose nanocrystals are uniformly dispersed in the layer A, so that the adsorption of water vapor on the layer A is reduced, the permeation of the water vapor is hindered, and the barrier property of the whole material is improved.

The invention relates to the technical field of plugging materials, and provides a low-temperature temporary plugging agent for fracturing and a preparation method thereof. The low-temperature temporary plugging agent for fracturing is prepared from the following raw material components: polycaprolactone, polylactic acid, polyglycolic acid, poly (butylene succinate), triglycidyl isocyanurate and silicon dioxide. The silicon dioxide comprises silicon dioxide A and silicon dioxide B; the silicon dioxide A is nano silicon dioxide; the silicon dioxide B is nano silicon dioxide composite micron silicon dioxide. Through the technical scheme, the problem of low strength of the low-temperature temporary plugging agent in related technologies is solved.

The invention relates to the technical field of cosmetic preparation, and discloses a preparation method and application of micro-capsule oil bead essence, and the preparation method of the micro-capsule oil bead essence comprises the following steps: S1, wall material preparation: taking 10-16 parts of sodium alginate, 10-14 parts of gelatin and 20-28 parts of polylactic acid-glycolic acid copolymer; s2, preparing a wall material solution; s3, preparing a core material; s4, preparation of core material emulsion: slowly adding the core material into deionized water containing an emulsifier while stirring; s6, curing and forming; and S7, post-treatment: carrying out separation and collection on the cured microcapsules in manners of centrifugation, filtration and the like. The micro-capsule oil bead essence is reasonable in design, and the micro-capsule oil bead essence can deeply moisturize. Hyaluronic acid can absorb a large amount of moisture, so that the skin is moisturized for a long time; ceramide can repair skin barrier and reduce water loss; the glycerin solution is used as a moisturizer, so that the moisturizing effect is further enhanced, and the skin is kept in a tender state all the time.

The invention belongs to the technical field of plastic, and particularly relates to a preparation method of high-temperature-resistant degradable plastic and application of the high-temperature-resistant degradable plastic in food packaging. The preparation method of the high-temperature-resistant degradable plastic comprises the following steps: (1) weighing the following raw materials in parts by mass: 65-70 parts of polylactic acid, 15-20 parts of polyethylene glycol terephthalate, 10-14 parts of polyglycolic acid, 4-8 parts of poly (butylene succinate), 3-6 parts of filler, 2-5 parts of compatilizer and 1-2 parts of plasticizer; and (2) mixing the raw materials, putting the mixture into a double-screw extruder, and carrying out melt extrusion to obtain the high-temperature-resistant degradable plastic. The high-temperature-resistant degradable plastic prepared by the preparation method disclosed by the invention is excellent in high temperature resistance, tensile property and impact resistance. The plastic material disclosed by the invention can be safely used for manufacturing food packaging products, is particularly suitable for food packaging, transportation and storage scenes needing to tolerate a certain temperature, and is beneficial to promoting the deep application of degradable materials in the food industry.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The invention discloses a coated yttria-90 loaded radioactive microsphere and a preparation method and application thereof, and relates to the technical field of radioactive microsphere preparation, and the preparation method comprises the following steps: preparing a polyvinyl alcohol microsphere by using a microfluidic technology; the preparation method comprises the following steps: labeling polyvinyl alcohol microspheres with yttrium-90 radionuclide to obtain yttrium-90 loaded radiation microspheres; and coating the polylactic acid-glycolic acid copolymer on the surface of the yttria-90 loaded radioactive microsphere to obtain the coated yttria-90 loaded radioactive microsphere. The composite radioactive microspheres with uniform particle size, stable radioactivity and controllable characteristics can be obtained, and the composite radioactive microspheres are expected to be applied to transcatheter arterial radioembolism (TARE) treatment of liver cancer.

The invention relates to a method for continuously producing poly (p-dioxanone), which comprises the following steps: premixing glycollic acid or a glycollic acid derivative with a ring formation catalyst, and introducing the obtained mixed material and ethylene oxide into a synthesis reaction kettle for reaction; separating and purifying the obtained reaction product, introducing the obtained purified monomer into a polymerization reaction kettle, and adding a polymerization catalyst for polymerization; after polymerization is finished, discharging is conducted, residual materials in the polymerization reaction kettle are subjected to depolymerization treatment to clean the kettle body, after depolymerization is finished, depolymerization products generated in the depolymerization treatment process are discharged, the kettle does not need to be opened for cleaning, and the next round of polymerization production is directly conducted. According to the method disclosed by the invention, the steps of synthesizing the p-dioxanone monomer, separating and purifying the monomer, catalyzing and polymerizing, depolymerizing and cleaning the kettle body and the like are continuously carried out, so that the continuous production of the poly (p-dioxanone) is realized, the side reaction of oligomerization and degradation of the p-dioxanone in storage and transportation can be avoided, and the production cost of the poly (p-dioxanone) is obviously reduced.

This proposal discloses an additive and method for producing ultra-thin electrolytic copper foil with high tensile strength and high elongation. The additive comprises an inorganic nitrate and an organic compound; the inorganic nitrate is one or a combination of ammonium nitrate, copper nitrate, and bismuth nitrate; and the organic compound is a crown ether, a cyclic alcohol, and glycolic acid. By adding the inorganic nitrate / organic compound additive, the present invention produces ultra-thin electrolytic copper foil with a thickness of 6 μm or less, achieving a tensile strength exceeding 500 MPa and an elongation exceeding 5%.

The application relates to the technical field of medical suture materials, and particularly discloses a non-absorbable suture with tissue self-adaptive performance, which comprises a core layer, a transition layer and an outer layer; the core layer and the transition layer are fixed through hot melt adhesion, and the outer layer is coated on the surface of the transition layer through electrostatic spinning; the core layer is a polyether ether ketone fiber with a diameter of 50-100 mu m and a tensile modulus of greater than or equal to 3 Gpa; the transition layer is a nickel-titanium alloy wire braided net with a thickness of 40-60 mu m, and the wire diameter of the nickel-titanium alloy wire is 20-30 mu m; and the outer layer is a poly-lactic acid-glycolic acid copolymer coating layer containing nano-hydroxyapatite with a thickness of 30-50 mu m; and the application further provides a preparation method of the non-absorbable suture. The non-absorbable suture has the advantages of tissue self-adaptive performance, persistent mechanical support and bioactivity, can effectively avoid tissue cutting, abrasion and suture loosening, and can reduce the incidence of postoperative complications such as inflammation and pain.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

This application provides a method for fabricating a solar cell and a solar cell. The method includes: forming a composite sacrificial layer on the surface of a solar cell substrate; forming an ink mask on the side of the composite sacrificial layer facing away from the solar cell substrate, the ink mask comprising microcapsules, each microcapsule comprising a wall and a core, the wall material comprising polylactic acid-glycolic acid copolymer, and the core material comprising sodium bicarbonate; patterning the ink mask and composite sacrificial layer using a laser processing technique to form a target pattern matching grid lines, thereby exposing a portion of the solar cell substrate; the composite sacrificial layer serving to buffer stress generated by the laser and absorb laser light during subsequent fabrication; forming grid lines on the exposed solar cell substrate; and removing the ink mask and composite sacrificial layer. This application solves the problem of poor quality solar cells obtained by existing solar cell fabrication methods.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The invention relates to the field of polyglycolic acid modification and application, and discloses a polyglycolic acid modified material composition with temporary plugging and pressurizing performance, which comprises the following components in parts by weight: 60-90 parts of polyglycolic acid A, 6-31 parts of imbibition agent B, 0.1-1.2 parts of accelerant C and 2-10 parts of dispersing agent D, wherein the weight-average molecular weight of the polyglycolic acid A is 50-150 thousand g / mol. The polyglycolic acid modified material composition has the advantages of high impact strength, high compression strength, compression resistance higher than 30 MPa and pressure bearing time longer than 4 hours under the medium and low temperature oil reservoir geology (less than or equal to 65 DEG C) condition, achieves the purpose and effect of temporary plugging of new turnaround fracturing seams, accelerates degradation after 6 hours under the medium and low temperature oil reservoir condition after being injected into the stratum seams along with fracturing fluid, and has the advantages of low cost and high efficiency. And moreover, complete degradation can be realized within 72 hours, residues after degradation are less than 5%, blockage removal is not needed, no damage is caused to a stratum, and the productivity of an oil well can be obviously improved.

The application provides a wear-resistant and sweat-resistant acrylic paint, a preparation method and application thereof, and belongs to the technical field of paints.The wear-resistant and sweat-resistant acrylic paint disclosed by the application is composed of the following raw materials in parts by weight: 30-50 parts of water-based acrylic resin, 15-20 parts of cashew phenol-based polyurethane resin, 0.8-1.5 parts of adhesion promoter, 3-5 parts of titanate coupling agent, 3-15 parts of filler, 0.5-1.8 parts of thickening agent, 0.5-2.0 parts of leveling agent, 0.5-1.0 parts of wetting agent, 0.5-1.5 parts of defoaming agent, 0.5-2 parts of cosolvent and 5-15 parts of water; wherein the components of the water-based acrylic resin include acrylic monomer, dithio glycolic acid, tri-n-butyl borane and aziridine crosslinking agent; and a preparation method of the acrylic paint is also provided.The acrylic paint provided by the application has excellent mechanical properties, good adhesion, excellent water resistance, scratch resistance, wear resistance, chemical resistance, sweat resistance and corrosion resistance and the like, and can be applied to 3C products and the glasses industry, thereby prolonging the service life of the products.

The invention discloses a hydroxyl-alpha-sanshool nano preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the hydroxyl-alpha-sanshool nano preparation is HAS-coated PEG-PLGA, the preparation method comprises the following steps: taking hydroxyl-alpha-sanshool and polyethylene glycol modified polylactic acid-glycolic acid copolymer as raw materials, and adding the hydroxyl-alpha-sanshool nano preparation and the polyethylene glycol modified polylactic acid-glycolic acid copolymer to prepare the hydroxyl-alpha-sanshool nano preparation. The preparation method comprises the following steps: preparing HAS-coated TGN-PEG-PLGA by adopting an emulsified solvent evaporation method, and further modifying by adopting TGN polypeptide, so as to prepare HAS-coated TGN-PEG-PLGA; according to the hydroxyl-alpha-sanshool nano-preparation, the encapsulation efficiency and the drug loading capacity of hydroxyl-alpha-sanshool are obviously improved, and the hydroxyl-alpha-sanshool nano-preparation has excellent stability and blood-brain barrier crossing capacity, so that the hydroxyl-alpha-sanshool nano-preparation can give full play to the treatment effects of improving learning and memory ability, cognitive ability and the like.

The application discloses a bone-integrative degradable silica gel support for treating bone nonunion and a preparation method thereof, and relates to the technical field of medical implant materials.The preparation method comprises the following steps: hydrogen-containing silicone oil and allyl glycidyl ether are subjected to a hydrosilylation reaction under the action of a platinum catalyst to generate silicone oil containing an epoxy group, then the epoxy group is subjected to ring-opening under the action of a catalyst to obtain silicone oil containing a phosphate group in a side chain; carboxyl-terminated polylactic acid-glycolic acid copolymer is mixed with the silicone oil containing the phosphate group in the side chain, and a condensation reaction is carried out under the action of a condensing agent and a catalyst to obtain a PLGA-P-PDMS-PLGA triblock copolymer; the triblock copolymer, a reactive diluent, a photoinitiator and inorganic reinforcing fillers are mixed to obtain 3D printing slurry; and the printing slurry is printed into a designed bone-integrative support according to set printing parameters by using a light-curing 3D printing technology.The application endows the material with intrinsic osteogenic activity, and realizes the unification of bioactivity, shape memory function and mechanical support.

The invention relates to the technical field of medical biological materials, and particularly discloses a composite electret flexible biological electrostatic electret patch and a preparation method thereof.The electrostatic electret patch comprises a backing layer, a medical pressure-sensitive adhesive layer and a functional layer which are sequentially arranged from outside to inside. According to the functional layer, at least one of polylactic acid, polyvinylidene fluoride and a polylactic acid-glycolic acid copolymer is selected as a polymer matrix to be compounded with graphene, a specific process combining ultrasonic dispersion and high-precision 3D printing is adopted, a deep-energy-level charge trap is introduced, the problems of high-conductivity filler agglomeration and surface charge leakage are solved, and the conductivity of the graphene is improved. The surface potential retention rate of the material can reach 60% or above after 900 days, the charge loss rate is not larger than 20% after 8-hour air exposure, and efficient physical electrostatic electret assisted sleep treatment under the drug-free and non-transdermal conditions is achieved.

Provided is a molded body in which the thickness reduction rate is increased after the thickness is reduced by 5 mm or more from the initial thickness while maintaining tensile strength. This molded body contains a glycolic acid polymer, a cyclic ester, a basic metal oxide, and a carboxylic acid anhydride, and the content of the cyclic ester is 21 parts by mass or less and the inter-particle closest distance of the basic metal oxide is 9.1 [mu] m or less when the total mass of the glycolic acid polymer, the cyclic ester, the basic metal oxide, and the carboxylic acid anhydride is taken as 100 parts by mass.

The invention discloses a synthesis method of a high-purity and high-yield antihypertensive drug, and relates to the technical field of medical chemistry. The method comprises the following steps: taking glycollic acid as an initial raw material, and carrying out acylation to obtain glycollic acid acyl chloride; carrying out Friedel-Crafts reaction on the 2-hydroxyl-5-(2-hydroxyacetyl) benzamide and salicylamide to obtain 2-hydroxyl-5-(2-hydroxyacetyl) benzamide; then, a Dess-Martin oxidizing agent is used for oxidation, and 2-hydroxy-5-(2-oxoacetyl) benzamide is obtained; the preparation method comprises the following steps: taking 2-hydroxyl-5-((4-phenylbutylamine-2-yl)-ethyl) benzamide as a raw material, then carrying out reductive amination on the 2-hydroxyl-5-(4-phenylbutylamine-2-yl)-ethyl) benzamide and 1-methyl-3-phenylpropylamine under the condition that sodium borohydride is taken as a reducing agent to obtain 2-hydroxyl-5-(1-hydroxyl-2-((4-phenylbutylamine-2-yl)-amino) ethyl) benzamide, namely And finally salifying with concentrated hydrochloric acid, crystallizing and separating to obtain the labeolol hydrochloride. The method is novel in route, convenient to operate, high in product total yield, high in purity, capable of effectively avoiding generation of dibromo impurities and suitable for large-scale production.

The invention discloses a modified PGA degradable material and a preparation method thereof, and belongs to the technical field of polyglycolic acid (PGA) preparation. The preparation method comprises the following steps: carrying out an esterification reaction on a mixed solution containing raw materials, an auxiliary agent and a catalyst until the mixed solution is clear and transparent, and then carrying out a condensation polymerization reaction to obtain the modified PGA degradable material, the raw material is glycollic acid and / or glycollate; the auxiliary agent is a polybasic acid auxiliary agent and / or a polyhydric alcohol auxiliary agent. Through use of the binary acid and dihydric alcohol combined auxiliary agent, the effects of reducing the melting point of the PGA and widening the processing window of the PGA are achieved, so that the PGA is smoother in the processing and forming process.

The application discloses a kind of high transparent degradable film materials and its preparation method and application. The film material is prepared based on PGA using the method of the application, the film material with higher transparency, lower haze can be obtained, and the film material also has improved tensile toughness. The preparation method comprises the following steps: uniformly mixing raw materials, then melt blending extrusion is carried out in double screw extruder and granulation, the obtained particles are pressed into film, then cooled to obtain film, and when cooling, the cooling rate is controlled to be ≥150 ℃ / min, preferably 150-300 ℃ / min;The raw materials include the following components: 90-98 parts by weight of polyglycolic acid, 0.3-2 parts by weight of antioxidant, 0.5-3 parts by weight of melt compatibilizer, 1-5 parts by weight of modifier;The modifier is selected from terephthalamide.

The invention discloses biodegradable high-barrier-property PGA coated paper as well as a preparation method and application thereof, and belongs to the technical field of coated paper. The invention aims to solve the technical problem that in the prior art, a PGA molecular chain processing window is narrow in temperature and unstable at high temperature, so that the service life of the prepared PGA coated paper is shortened. The preparation method of the biodegradable high-barrier-property PGA coated paper comprises the following steps: S1, adding modified polyglycolic acid, a polyurethane elastomer and an initiator into an internal mixer for internal mixing to obtain a polymer; and cooling the polymer to obtain the prepared lamination layer material. S2, coated paper is used as a base material, PLA is used as a bonding layer material to coat the surface of the base material, then a lamination layer material is laminated, and the biodegradable high-barrier-property PGA lamination paper is prepared through pressing of a hot pressing roller. The PGA coated paper prepared by the invention has the advantages of excellent thermal stability and mechanical properties and good biodegradability.

The present invention provides a kind of ink with lasting fragrance and preparation method thereof, belong to the field of ink technology, the ink with lasting fragrance comprises the following raw materials in parts by weight: 20-40 parts of tripropylene glycol diacrylate, 10-20 parts of trimethylolpropane triacrylate, 20-50 parts of polyurethane acrylate, 1-5 parts of silicone acrylate, 4-6 parts of photoinitiator, 1-5 parts of active amine co-initiator, 3-5 parts of fragrance sustained-release capsule, 0.3-0.5 parts of defoamer, 5-15 parts of solvent; wherein, the fragrance sustained-release capsule is composed of an oil phase consisting of plant essential oil, polylactic acid-co-glycolic acid copolymer, PCL-PEG grafted cyclodextrin and ethyl acetate, and an aqueous phase consisting of polyvinyl alcohol in water, and is made by high-pressure homogenization, rotary evaporation and drying. The ink fragrance prepared by the present invention lasts for a long time and has the characteristics of good stability, strong adhesion, fast curing, scratch resistance, and green environmental protection.

The invention relates to the field of high polymer materials, and particularly discloses a biodegradable composite express packaging bag and a preparation method thereof. A biodegradable composite express packaging bag comprises an outer layer film, a fiber layer, a framework layer, a fiber layer and an inner layer film. The outer layer film and the inner layer film are PBAT blended films, and the PBAT blended films are prepared from the following raw materials in parts by weight: 5 to 6 parts of PBAT resin, 1 to 1.5 parts of polyglycolic acid, 3 to 4 parts of polypropylene carbonate, 0.05 to 0.1 part of compatilizer, 0.15 to 0.2 part of antioxidant and 0.1 to 0.15 part of lubricant; the raw materials of the fiber layer comprise PBAT resin, PBST resin and a compatibilizer, and the fiber layer is prepared through melt differential electrostatic spinning; and the framework layer is an aramid nanofiber layer loaded with MOF-808. The biodegradable composite express packaging bag has the advantages of being high in longitudinal and transverse tensile strength, high in tear resistance, suitable for express packaging, capable of being biodegraded and excellent in barrier property.

The invention discloses a nano-robot based on tear driving, a preparation method of the nano-robot and application of the nano-robot in eye drops. The preparation method comprises the following steps: step 1, loading ophthalmic disease treatment drugs such as amphotericin B, voriconazole and natamycin into nano-particles such as polylactic acid-glycolic acid copolymer, chitosan and sodium alginate; 2, coupling urease on the surfaces of the nano-particles to obtain a nano-robot with autonomous movement ability; step 3, performing morphology characterization on the obtained nanometer robot driven by the tear liquid; and step 4, dispersing the prepared tear-driven nano-robot in a buffer solution to prepare the eye drops. The tear-driven nano-robot can utilize urea in tears as fuel to generate cluster motion on the cornea surface, so that the retention time is remarkably prolonged, the drug retention amount is increased, and the treatment effect is improved. The nano-robot eye drops based on tear driving have biocompatibility and treatment safety, and have wide application prospects in the field of ophthalmic local administration.

The present application relates to the field of new material fine chemicals, and particularly relates to a low-cost preparation of a series of carbon four (C4) diacid (ester) by using coal chemical industry abundant oxalate and / or glycollic acid (ester) bulk raw materials, including butene diacid (ester), succinic acid (ester), tartaric acid (ester), and / or malic acid (ester) and the like, and the process features are that all of the coal chemical industry abundant carbon monoxide (synthesis gas), methanol, or formaldehyde and the like bulk C1 raw materials are used, and a series of C4 skeleton products are simply and efficiently prepared. The technology practices outstanding cost reduction and efficiency improvement results, and is beneficial to large-scale preparation of high-value chemicals relying on rich coal resources in China.

The present application relates to a kind of absorbable bone hemostasis repair bracket, the absorbable bone hemostasis repair bracket includes the following weight parts of raw materials: excipient 15~60 parts, softening agent 15~60 parts and promote bone repair component 5~70 parts;The excipient includes polyoxyethylene-polyoxypropylene copolymer;The softening agent includes semi-solid mobile phase polymer;The promote bone repair component includes coating and core, the coating includes polylactic acid-glycolic acid copolymer, zinc stearate and potassium bromide, the core includes calcium phosphate salt particle, and the coating is wrapped in the surface of core.The preparation method includes the following steps: the preparation of promote bone repair component;The preparation of absorbable bone hemostasis repair bracket.The present application absorbable bone hemostasis repair bracket hemostasis anti-ability of scattering is strong, and has good inflammation regulation and promote bone repair effect.The present application absorbable bone hemostasis repair bracket can be used for any bone injury wound surface bone hemostasis and promote bone repair.

The embodiment of the application relates to the technical field of medical coating materials, and particularly relates to a method for forming an active coating on the surface of a degradable occlusion device and the degradable occlusion device, the method comprising the following steps: preparing perfluorohexane liposomes loaded with stromal cell-derived factor-1 alpha (SDF-1 alpha); preparing polylactic acid-glycolic acid copolymer@rapamycin@nitric oxide donor nanoparticles; preparing a methacrylated gelatin-tannic acid hydrogel carrier; mixing the liposomes and the nanoparticles into the hydrogel carrier; soaking the degradable occlusion device in the mixture obtained in the previous step, and performing light crosslinking treatment on the mixture, so that an active coating is formed on the surface of the degradable occlusion device. Therefore, comprehensive consideration of "endothelialization repair in the early implantation period - myocardial tissue remodeling after implantation" is realized, controllable time-sequencing repair of the degradable occlusion device on the heart defect site is ensured, and the endogenous functional repair effect of the heart of a patient is improved.