145 results about "Glycollic acid" patented technology

The invention discloses an anti-adhesion membrane loaded with nintedanib and a preparation method of the anti-adhesion membrane loaded with the nintedanib. The anti-adhesion membrane loaded with the nintedanib is prepared from a drug-loading substrate material and the nintedanib through electrostatic spinning, the material of the drug-loading substrate is one or more of polylactic acid, poly (p-dioxanone), a polylactic acid-glycolic acid copolymer, polycaprolactone and polyethylene glycol; a solvent adopted in the electrostatic spinning is hexafluoroisopropanol, and the voltage adopted in the electrostatic spinning is 10-14 kV. The nintedanib-loaded anti-adhesion membrane has the advantages that the tensile strength and the elongation at break are obviously improved, the mechanical property is obviously improved, the fiber distribution is uniform, the obvious anti-adhesion effect is realized, the nintedanib-loaded anti-adhesion membrane is suitable for common laparotomy, and the application prospect is wide.

The invention provides a high-hydrophobicity anti-pollution flashover coating and a preparation method thereof, and relates to the field of coatings. The silicone rubber composition is prepared from the following raw materials in parts by weight: 80 to 100 parts of hydroxyl-terminated polydimethylsiloxane; 5 to 15 parts of modified nano silicon dioxide; 10 to 30 parts of a composite self-repairing microcapsule; 10 to 25 parts of a flame retardant; 3-8 parts of a cross-linking agent; 0.5-2 parts of a catalyst; 1-5 parts of an accelerant; 40 to 100 parts of a solvent; the modified nano silicon dioxide is fumed silica subjected to surface treatment by a fluorine-containing silane coupling agent and a platinum catalyst; the capsule wall of the composite self-repairing microcapsule is a polylactic acid-glycolic acid copolymer, and the capsule core of the composite self-repairing microcapsule is a mixed solution of a hydroxyl-terminated polydimethylsiloxane oligomer and methyltris (methylethylketoximino) silane. The coating has excellent hydrophobicity, weather resistance and targeted repair function.

The invention discloses a liquid chromatography determination method for a mixed solution of glyoxylic acid, glycollic acid and oxalic acid and application. The method comprises the following steps: (1) preparing standard solutions with different concentrations; (2) detecting the standard solutions with different concentrations by using high performance liquid chromatography; (3) establishing a linear regression equation of each acid according to the relationship between the concentration of the standard solution and the corresponding peak area; (4) pre-treating a sample to be detected, detecting under the same condition as that in the step (2) by using high performance liquid chromatography, and recording the peak area of each acid in the sample to be detected; and (5) substituting the peak area of each acid in the to-be-detected sample into the corresponding linear regression equation, and calculating to obtain the concentrations of glyoxylic acid, glycollic acid and oxalic acid in the to-be-detected sample. The method is a liquid chromatographic determination method which is simple and convenient to operate, excellent in separation effect, mild in chromatographic condition and compatible with various detectors, can accurately quantify three strong-polarity mixed acids of glyoxylic acid, glycollic acid and oxalic acid, and has important practical application value.

The invention discloses preparation of a layered mesoporous Pd-Cu nano-catalyst and a method for preparing glycollic acid from PET hydrolysate through electro-oxidation under environmental conditions, and belongs to the technical field of catalysts. The preparation method comprises the following steps: dissolving CTAB (Cetyltrimethyl Ammonium Bromide) serving as a surfactant in a cosolvent of water and TMB (Tetramethylbenzidine), sequentially adding NH4PdCl4 and Cu (NO3) 2.3 H2O serving as metal precursors into a reaction solution, and finally synthesizing the layered mesoporous Pd-Cu by virtue of a reduction effect of sodium borohydride and an in-situ nucleation and adhesion method. Continuous electro-catalysis is carried out in a pulse mode, selective desorption of GA is dynamically accelerated, and new active sites of a metal catalyst are exposed. The electric pulse catalysis can promote the desorption of the product, prevent poisoning, and further improve the stability and selectivity of the catalyst. The method shows excellent glycollic acid Faraday efficiency, high generation rate and excellent cycle stability under a wide potential window, 20 times of electro-catalysis PET upgrading cycles are achieved, and upgrading utilization of PET waste and efficient generation of glycollic acid are achieved.

The invention relates to a multilayer packaging material with high barrier property and application thereof. The multi-layer packaging material at least comprises three layers, namely a layer A, a layer B and a layer C, wherein the layer B is located between the layer A and the layer C; the layer A is prepared from the following raw materials: first biodegradable polyurethane and a cellulose nanocrystal graft which is obtained by performing grafting treatment on cellulose nanocrystal after hydrophobic modification, and the content of the cellulose nanocrystal graft is 1wt%-10wt% of that of the first biodegradable polyurethane; the raw material of the layer B comprises biodegradable polyester containing a glycollic acid structural unit, and the content of the glycollic acid structural unit is not less than 60% mol; the raw material of the layer C comprises second biodegradable polyurethane. The hydrophobic modified cellulose nanocrystals are uniformly dispersed in the layer A, so that the adsorption of water vapor on the layer A is reduced, the permeation of the water vapor is hindered, and the barrier property of the whole material is improved.

The invention provides a method for preparing glycollic acid through ethylene glycol oxidation, which comprises the following steps: carrying out oxidation reaction on ethylene glycol under the action of a catalyst to obtain glycollic acid, the pressure of the oxidation reaction is 1.0-2.0 MPa, the temperature is 60-80 DEG C, and the dosage ratio of the catalyst to the ethylene glycol is 1g: (10-20) mol; a carrier of the catalyst comprises a mesoporous molecular sieve, an active component of the catalyst comprises Pt, and auxiliary active components of the catalyst comprise Mn, Sn and Bi; based on 100% of the mass of the catalyst, the content of Pt is 0.8%-1.6%, and the total content of Sn, Bi and Mn is 1.0%-3.5%. According to the method, the selectivity of glycollic acid and the yield of ethylene glycol are remarkably improved by adopting the catalyst which takes Pt as an active component and Mn, Sn and Bi as auxiliary active components and combining parameters such as limited catalyst dosage, reaction pressure and temperature.

The present invention discloses a kind of ultrafine slag powder grinding aid and preparation method thereof, belong to the technical field of grinding admixture. The grinding aid of the present invention is prepared by including the following raw materials in parts by weight: 20-40 parts of small molecule polyether polyols, 10-20 parts of ethylene glycol and diethylene glycol mixed solution, 5-10 parts of water glass, 0.1-0.5 parts of sodium hexadecylsulfonate, 0.1-0.5 parts of defoamer and 20-40 parts of water. The present invention adopts ethylene oxide and glycolic acid to synthesize small molecule polyether polyol oligomers, which can adapt to slag of different particle sizes, achieve good adsorption and dispersion, effectively solve the agglomeration problem of slag differential during ultrafine grinding, and have a good grinding aid effect on slag. The obtained grinding aid can effectively improve the efficiency of ultrafine grinding of slag powder, shorten the time of ultrafine grinding, and increase the output by 20% per hour.

The invention relates to 6-methyl nicotine glycollate and a preparation method thereof, an atomization matrix, a buccal product and an electronic atomization device. The preparation method of the 6-methylnicotine glycollate comprises the following steps: mixing 6-methylnicotine, glycollic acid and a metal catalyst for reaction to obtain a reaction solution containing the 6-methylnicotine glycollate; and carrying out physical adsorption treatment on the reaction liquid to prepare the 6-methyl nicotine glycolate. 6-methylnicotine and glycollic acid react under the action of a metal catalyst, so that the conversion rate of a reaction substrate can be effectively promoted, and residues of the reaction substrate are effectively reduced; the obtained reaction liquid is further subjected to physical adsorption treatment, so that the residual catalyst in the reaction liquid can be effectively removed, and the prepared 6-methyl nicotine glycolate has less heavy metal residue.

The invention belongs to the technical field of medical packaging materials, and particularly relates to a degradable medical packaging material and a preparation method thereof. The degradable medical packaging material is prepared from the following raw materials in parts by weight: 40 to 50 parts of a polylactic acid-glycollic acid copolymer, 40 to 50 parts of polycaprolactone, 1 to 3 parts of an antiviral agent, 0.05 to 0.1 part of an antibacterial agent, 2 to 6 parts of a plasticizer and 0.02 to 0.05 part of an antioxidant, the structural formula of the antiviral agent is # imgabs0 #, wherein n is equal to 5, 6 or 7. The packaging material prepared by the invention has excellent antibacterial and antiviral properties and degradability.

The invention relates to the technical field of plugging materials, and provides a low-temperature temporary plugging agent for fracturing and a preparation method thereof. The low-temperature temporary plugging agent for fracturing is prepared from the following raw material components: polycaprolactone, polylactic acid, polyglycolic acid, poly (butylene succinate), triglycidyl isocyanurate and silicon dioxide. The silicon dioxide comprises silicon dioxide A and silicon dioxide B; the silicon dioxide A is nano silicon dioxide; the silicon dioxide B is nano silicon dioxide composite micron silicon dioxide. Through the technical scheme, the problem of low strength of the low-temperature temporary plugging agent in related technologies is solved.

The invention provides an anode catalyst, an electro-catalysis system containing the anode catalyst and a method for producing hydrogen through electro-catalysis ethylene glycol coupled seawater electrolysis. The anode catalyst includes a foam metal as a substrate material; the MCo2O4 spinel oxide is loaded on the foam metal; the palladium nano particles are loaded on the MCo2O4 spinel oxide; wherein M represents metal Mn, Fe, Ni, Cu or Zn. The anode catalyst is applied to hydrogen production through electrocatalysis of ethylene glycol coupled with seawater electrolysis, and shows relatively high selectivity, catalytic activity and stability, which are specifically embodied in that when the industrial-grade current density (600mA cm < 2 >) is reached, the working voltage is only 1.14 V; when the ethylene glycol is completely electrolyzed, the yield of the glycollic acid is as high as 92.6%; meanwhile, the anode catalyst can realize stable electrolysis for more than 100 hours under a seawater condition, and is superior to all current palladium-based ethylene glycol oxidation catalysts.

The invention discloses a preparation method of a gradient pore-forming magnesium-containing calcium phosphate bone repair material, which comprises the following steps: S1, mixing nano-hydroxyapatite with polylactic acid-glycolic acid copolymer (PLGA) powder, adding dichloromethane as a solvent, continuously stirring to form a solution, and freeze-drying to obtain an nHA / PLGA raw material, and carrying out high-temperature fused deposition through a 3D biological printer to prepare the degradable nPLGA stent. S2, weighing the calcium phosphate bone cement powder and the magnesium metal microspheres according to a preset mass ratio, stirring the slurry and homogenizing to obtain calcium phosphate bone cement slurry containing the magnesium metal microspheres; s3, injecting the calcium phosphate bone cement slurry obtained in the step S2 into the nPLGA stent prepared in the step S1 to obtain an MC / nPLGA compound; gradient micropores are generated through hydration reaction of the magnesium microspheres, the gradient micropores and macropores formed by degradation of PLGA form a complementary structure, and the total porosity reaches 68% and is increased by 3.4 times compared with traditional CPC.

The invention discloses a preparation process of an oxidation film on the inner wall of a precise aluminum pipe, which comprises the following steps: step 1, oxidizing the aluminum pipe by adopting a semi-hard anodic oxidation electrolyte and a pulse current with the density of 1.5-2A / dm < 2 > in a bath solution temperature environment of 15-20 DEG C, the semi-hard anodic oxidation electrolyte comprises sulfuric acid with the concentration of 12%-15%, oxalic acid with the concentration of 2%-3% and glycolic acid with the concentration of 0.5%-1%. Step 2, carrying out hole sealing treatment on the oxide film on the inner wall of the aluminum pipe by using a nickel salt-containing medium-temperature hole sealing agent; 3, the aluminum pipe is soaked in methyl phenyl silicone resin, and meanwhile the permeability of the methyl phenyl silicone resin is improved through ultrasonic-assisted permeation; and 4, the aluminum pipe is baked, so that the methyl phenyl silicone resin permeates into the oxidation film on the inner wall of the aluminum pipe to form the composite coating. By adopting semi-hard anodic oxidation, the requirement of 3000 times of friction wear resistance of the selfie telescopic rod can be met, the cost is obviously lower than that of hard anodic oxidation, and mass production is facilitated.

The invention relates to the technical field of cosmetic preparation, and discloses a preparation method and application of micro-capsule oil bead essence, and the preparation method of the micro-capsule oil bead essence comprises the following steps: S1, wall material preparation: taking 10-16 parts of sodium alginate, 10-14 parts of gelatin and 20-28 parts of polylactic acid-glycolic acid copolymer; s2, preparing a wall material solution; s3, preparing a core material; s4, preparation of core material emulsion: slowly adding the core material into deionized water containing an emulsifier while stirring; s6, curing and forming; and S7, post-treatment: carrying out separation and collection on the cured microcapsules in manners of centrifugation, filtration and the like. The micro-capsule oil bead essence is reasonable in design, and the micro-capsule oil bead essence can deeply moisturize. Hyaluronic acid can absorb a large amount of moisture, so that the skin is moisturized for a long time; ceramide can repair skin barrier and reduce water loss; the glycerin solution is used as a moisturizer, so that the moisturizing effect is further enhanced, and the skin is kept in a tender state all the time.

The invention relates to the technical field of electrochemistry, and particularly discloses a novel PdCuCo trimetal alkene material as well as a preparation method and application thereof. The novel PdCuCo trimetal alkene material is a PdCuCo trimetal alloy nanosheet, has ultra-thin (1nm) thickness and rich lattice defects, and is prepared by the following steps: adding polyvinylpyrrolidone, bis (acetylacetone) palladium, copper acetylacetonate and cobalt acetylacetonate into a mixed solution of ethylenediamine and N, N-dimethylformamide, carrying out solvothermal reaction and freeze drying treatment, and preparing the novel PdCuCo trimetal alkene material. And the PdCuCo trimetal alkene is obtained. The preparation method disclosed by the invention is a simple one-pot solvothermal method, high-temperature reaction is not involved, the obtained product has ultra-thin thickness, the utilization rate of Pd is effectively improved, the catalytic activity is obviously improved and the high selectivity of a glycollic acid product is high in the process of electrically reforming the PET plastic, and a solution can be provided for value-added utilization of the PET plastic.

The invention belongs to the technical field of plastic, and particularly relates to a preparation method of high-temperature-resistant degradable plastic and application of the high-temperature-resistant degradable plastic in food packaging. The preparation method of the high-temperature-resistant degradable plastic comprises the following steps: (1) weighing the following raw materials in parts by mass: 65-70 parts of polylactic acid, 15-20 parts of polyethylene glycol terephthalate, 10-14 parts of polyglycolic acid, 4-8 parts of poly (butylene succinate), 3-6 parts of filler, 2-5 parts of compatilizer and 1-2 parts of plasticizer; and (2) mixing the raw materials, putting the mixture into a double-screw extruder, and carrying out melt extrusion to obtain the high-temperature-resistant degradable plastic. The high-temperature-resistant degradable plastic prepared by the preparation method disclosed by the invention is excellent in high temperature resistance, tensile property and impact resistance. The plastic material disclosed by the invention can be safely used for manufacturing food packaging products, is particularly suitable for food packaging, transportation and storage scenes needing to tolerate a certain temperature, and is beneficial to promoting the deep application of degradable materials in the food industry.

The invention discloses a catalyst for synthesizing glycollic acid and a preparation method. The catalyst comprises the following components in percentage by weight: 5-10% of copper oxide, 15-40% of manganese oxide, zirconium oxide or cerium oxide and 50-80% of modified aluminum oxide. The preparation method comprises the following steps: adding a certain amount of copper-containing compound solution into aluminum oxide powder modified by manganese chloride, zirconium chloride or cerium chloride, adding gel containing water, binder methyl cellulose and peptizing agent, uniformly kneading on a kneading machine, and extruding and molding the kneaded material on a banded extruder to obtain the copper-containing aluminum oxide composite material. And drying and roasting to obtain the catalyst for synthesizing glycollic acid. The catalyst for synthesizing glycollic acid, prepared by the invention, takes modified aluminum oxide as a main component, and has better activity and performance; the preparation process provided by the invention is relatively environment-friendly, and has a relatively good application prospect.

The invention discloses a method for biosynthesizing dicarbon organic acid by using CO2, and belongs to the technical field of bioengineering. A path for synthesizing glyoxylic acid and glycollic acid by taking CO2 as a substrate is designed, and a first reaction module for converting CO2 and acetyl coenzyme A into pyruvic acid and a second reaction module for converting pyruvic acid into malic acid are obtained through thermodynamic evaluation and screening of pathase. The third reaction module is used for converting malic acid into acetyl coenzyme A and glyoxylic acid, the fourth reaction module is used for converting glyoxylic acid into glycollic acid, and PSP circulation is carried out on the four reaction modules. Through an experimental method of a one-pot two-step method, 2.78 g / L of glyoxylic acid can be realized after 11 hours of catalytic reaction in total; and 1.78 g / L of glycollic acid. The invention successfully realizes a cell-free biosynthesis method for synthesizing glyoxylic acid and glycollic acid by taking CO2 as a substrate.

The invention provides a composition for changing plasticity of bone meal particles as well as a preparation method and application of the composition, and relates to the technical field of biomedical materials. The composition is prepared from the following raw material components: bioactive glass, dihydrazide modified sodium hyaluronate, sodium hyaluronate with the molecular weight of 50kDa to 500kDa, a polylactic acid-glycolic acid copolymer and carboxymethyl cellulose. The preparation method of the dihydrazide modified sodium hyaluronate comprises the following steps: carrying out carboxyl activation on sodium hyaluronate, carrying out a cross-linking reaction on the activated hyaluronic acid and adipic dihydrazide, and then terminating the reaction. The composition provided by the invention not only can provide support, but also can adjust the degradation rate to be matched with the bone regeneration period, and all the components synergistically improve the mechanical property and the viscoelastic property. The composition disclosed by the invention can be formed in situ at a bone defect part, provides a space for growth and proliferation of bone cells, improves the biological activity and osteoinductivity of an artificial bone, and promotes bone growth and repair.

The invention relates to the technical field of copolyester staple fibers, and discloses a preparation method of biodegradable aromatic-aliphatic copolyester staple fibers, which comprises the following steps: (1) mixing terephthalic acid, glycollic acid, ethylene glycol and a catalyst, and carrying out esterification reaction to obtain an esterified substance, with the molar weight ratio of terephthalic acid to glycollic acid being (60-80%): (20-40%), the total percentage is 100%. Mixing the esterified product with an antioxidant and a stabilizer, and performing condensation polymerization to obtain copolyester; and (2) drying the copolyester, carrying out melt extrusion, cooling to obtain a protofilament, bundling, oiling, drafting and shaping to obtain the copolyester staple fiber. Glycollic acid is introduced as a third monomer, and the polyester structure is modified from the molecular level, so that the polyester has certain mechanical strength and good spinnability while having good degradation performance.

The invention discloses a coated yttria-90 loaded radioactive microsphere and a preparation method and application thereof, and relates to the technical field of radioactive microsphere preparation, and the preparation method comprises the following steps: preparing a polyvinyl alcohol microsphere by using a microfluidic technology; the preparation method comprises the following steps: labeling polyvinyl alcohol microspheres with yttrium-90 radionuclide to obtain yttrium-90 loaded radiation microspheres; and coating the polylactic acid-glycolic acid copolymer on the surface of the yttria-90 loaded radioactive microsphere to obtain the coated yttria-90 loaded radioactive microsphere. The composite radioactive microspheres with uniform particle size, stable radioactivity and controllable characteristics can be obtained, and the composite radioactive microspheres are expected to be applied to transcatheter arterial radioembolism (TARE) treatment of liver cancer.

The invention relates to a method for continuously producing poly (p-dioxanone), which comprises the following steps: premixing glycollic acid or a glycollic acid derivative with a ring formation catalyst, and introducing the obtained mixed material and ethylene oxide into a synthesis reaction kettle for reaction; separating and purifying the obtained reaction product, introducing the obtained purified monomer into a polymerization reaction kettle, and adding a polymerization catalyst for polymerization; after polymerization is finished, discharging is conducted, residual materials in the polymerization reaction kettle are subjected to depolymerization treatment to clean the kettle body, after depolymerization is finished, depolymerization products generated in the depolymerization treatment process are discharged, the kettle does not need to be opened for cleaning, and the next round of polymerization production is directly conducted. According to the method disclosed by the invention, the steps of synthesizing the p-dioxanone monomer, separating and purifying the monomer, catalyzing and polymerizing, depolymerizing and cleaning the kettle body and the like are continuously carried out, so that the continuous production of the poly (p-dioxanone) is realized, the side reaction of oligomerization and degradation of the p-dioxanone in storage and transportation can be avoided, and the production cost of the poly (p-dioxanone) is obviously reduced.

This proposal discloses an additive and method for producing ultra-thin electrolytic copper foil with high tensile strength and high elongation. The additive comprises an inorganic nitrate and an organic compound; the inorganic nitrate is one or a combination of ammonium nitrate, copper nitrate, and bismuth nitrate; and the organic compound is a crown ether, a cyclic alcohol, and glycolic acid. By adding the inorganic nitrate / organic compound additive, the present invention produces ultra-thin electrolytic copper foil with a thickness of 6 μm or less, achieving a tensile strength exceeding 500 MPa and an elongation exceeding 5%.

The application relates to the technical field of medical suture materials, and particularly discloses a non-absorbable suture with tissue self-adaptive performance, which comprises a core layer, a transition layer and an outer layer; the core layer and the transition layer are fixed through hot melt adhesion, and the outer layer is coated on the surface of the transition layer through electrostatic spinning; the core layer is a polyether ether ketone fiber with a diameter of 50-100 mu m and a tensile modulus of greater than or equal to 3 Gpa; the transition layer is a nickel-titanium alloy wire braided net with a thickness of 40-60 mu m, and the wire diameter of the nickel-titanium alloy wire is 20-30 mu m; and the outer layer is a poly-lactic acid-glycolic acid copolymer coating layer containing nano-hydroxyapatite with a thickness of 30-50 mu m; and the application further provides a preparation method of the non-absorbable suture. The non-absorbable suture has the advantages of tissue self-adaptive performance, persistent mechanical support and bioactivity, can effectively avoid tissue cutting, abrasion and suture loosening, and can reduce the incidence of postoperative complications such as inflammation and pain.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

This application provides a method for fabricating a solar cell and a solar cell. The method includes: forming a composite sacrificial layer on the surface of a solar cell substrate; forming an ink mask on the side of the composite sacrificial layer facing away from the solar cell substrate, the ink mask comprising microcapsules, each microcapsule comprising a wall and a core, the wall material comprising polylactic acid-glycolic acid copolymer, and the core material comprising sodium bicarbonate; patterning the ink mask and composite sacrificial layer using a laser processing technique to form a target pattern matching grid lines, thereby exposing a portion of the solar cell substrate; the composite sacrificial layer serving to buffer stress generated by the laser and absorb laser light during subsequent fabrication; forming grid lines on the exposed solar cell substrate; and removing the ink mask and composite sacrificial layer. This application solves the problem of poor quality solar cells obtained by existing solar cell fabrication methods.

The application belongs to the technical field of pharmaceutical chemistry, and particularly relates to clofazimine-organic acid co-crystals, a preparation method and application thereof. The clofazimine-organic acid co-crystal is one of clofazimine-ferulic acid monohydrate co-crystal, clofazimine-ferulic acid co-crystal, clofazimine-glutaric acid co-crystal, clofazimine-glycolic acid co-crystal (CFZ-GA 1:1), clofazimine-glycolic acid co-crystal (CFZ-GA 1:1.5), clofazimine-salicylic acid co-crystal, clofazimine-L-aspartic acid co-crystal, clofazimine-L-pyroglutamic acid co-crystal, clofazimine-gallic acid co-crystal, clofazimine-succinic acid co-crystal, clofazimine-tartaric acid co-crystal and clofazimine-DL-mandelic acid co-crystal. The clofazimine-organic acid co-crystal provided by the application significantly improves the solubility and fluidity of clofazimine, thereby improving the bioavailability of clofazimine, and has a broad medicinal prospect.

The invention relates to the field of polyglycolic acid modification and application, and discloses a polyglycolic acid modified material composition with temporary plugging and pressurizing performance, which comprises the following components in parts by weight: 60-90 parts of polyglycolic acid A, 6-31 parts of imbibition agent B, 0.1-1.2 parts of accelerant C and 2-10 parts of dispersing agent D, wherein the weight-average molecular weight of the polyglycolic acid A is 50-150 thousand g / mol. The polyglycolic acid modified material composition has the advantages of high impact strength, high compression strength, compression resistance higher than 30 MPa and pressure bearing time longer than 4 hours under the medium and low temperature oil reservoir geology (less than or equal to 65 DEG C) condition, achieves the purpose and effect of temporary plugging of new turnaround fracturing seams, accelerates degradation after 6 hours under the medium and low temperature oil reservoir condition after being injected into the stratum seams along with fracturing fluid, and has the advantages of low cost and high efficiency. And moreover, complete degradation can be realized within 72 hours, residues after degradation are less than 5%, blockage removal is not needed, no damage is caused to a stratum, and the productivity of an oil well can be obviously improved.

The application provides a wear-resistant and sweat-resistant acrylic paint, a preparation method and application thereof, and belongs to the technical field of paints.The wear-resistant and sweat-resistant acrylic paint disclosed by the application is composed of the following raw materials in parts by weight: 30-50 parts of water-based acrylic resin, 15-20 parts of cashew phenol-based polyurethane resin, 0.8-1.5 parts of adhesion promoter, 3-5 parts of titanate coupling agent, 3-15 parts of filler, 0.5-1.8 parts of thickening agent, 0.5-2.0 parts of leveling agent, 0.5-1.0 parts of wetting agent, 0.5-1.5 parts of defoaming agent, 0.5-2 parts of cosolvent and 5-15 parts of water; wherein the components of the water-based acrylic resin include acrylic monomer, dithio glycolic acid, tri-n-butyl borane and aziridine crosslinking agent; and a preparation method of the acrylic paint is also provided.The acrylic paint provided by the application has excellent mechanical properties, good adhesion, excellent water resistance, scratch resistance, wear resistance, chemical resistance, sweat resistance and corrosion resistance and the like, and can be applied to 3C products and the glasses industry, thereby prolonging the service life of the products.

The invention discloses a hydroxyl-alpha-sanshool nano preparation as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the hydroxyl-alpha-sanshool nano preparation is HAS-coated PEG-PLGA, the preparation method comprises the following steps: taking hydroxyl-alpha-sanshool and polyethylene glycol modified polylactic acid-glycolic acid copolymer as raw materials, and adding the hydroxyl-alpha-sanshool nano preparation and the polyethylene glycol modified polylactic acid-glycolic acid copolymer to prepare the hydroxyl-alpha-sanshool nano preparation. The preparation method comprises the following steps: preparing HAS-coated TGN-PEG-PLGA by adopting an emulsified solvent evaporation method, and further modifying by adopting TGN polypeptide, so as to prepare HAS-coated TGN-PEG-PLGA; according to the hydroxyl-alpha-sanshool nano-preparation, the encapsulation efficiency and the drug loading capacity of hydroxyl-alpha-sanshool are obviously improved, and the hydroxyl-alpha-sanshool nano-preparation has excellent stability and blood-brain barrier crossing capacity, so that the hydroxyl-alpha-sanshool nano-preparation can give full play to the treatment effects of improving learning and memory ability, cognitive ability and the like.