Tissue induction biomedical material

A biomedical material and biofilm technology, applied in tissue regeneration, medical science, conjugated synthetic polymer rayon, etc., can solve the problems of antigenicity, difficulty in ensuring the identity of different batches of materials, and limited sources.

Inactive Publication Date: 2017-01-04
YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Natural biomaterials mainly include collagen, gelatin, chitosan, alginate, agarose, fibrin, hyaluronic acid, cancellous bone matrix and acellular matrix, etc., which have the advantage of good cell signal recognition and can promote cell Adhesion, proliferation and differentiation, good biocompatibility and biodegradation, the disadvantage is that the source is limited, difficult to process, it is difficult to ensure the identity of different batches of materials, there is antigenicity, and the degradation rate is difficult to control

Method used

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  • Tissue induction biomedical material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: Preparation of a medical biofilm that induces epidermal regeneration

[0051] The components are polyurethane: polylactic acid: collagen, and the percentage by weight is 50%: 10%: 40%;

[0052] Concrete preparation process is as follows:

[0053] (1) Prepare a mixed spinning solution of 5 g of polyurethane and 1 g of polylactic acid: dissolve 5 g of polyurethane and 1 g of polylactic acid in 50 ml of a mixed solution of DMF and tetrahydrofuran (1:1), stir until completely dissolved, and obtain a spinning solution;

[0054] The polyurethane is: poly(ε-caprolactone) diol (PCL) as the soft segment, L-lysine diisocyanate (LDI) and chain extender 1,4-butanediol (BDO) as the hard segment Polyurethane (PU), elastic modulus 400-500MPa adjustment, elongation at break 500-700%; polylactic acid: PLGA (LA:GA=3:1), viscosity average molecular weight 150,000.

[0055] (2) Put the above spinning solution in the electrospinning device, adjust the spinning industrial parame...

Embodiment 2

[0057] Example 2: Preparation of a medical biofilm that induces dermal regeneration

[0058] The components are polyurethane: polylactic acid: collagen: sodium hyaluronate, and the percentages by weight are 50%: 5%: 35%: 10%;

[0059] The polyurethane is: poly(ε-caprolactone) diol (PCL) as the soft segment, L-lysine diisocyanate (LDI) and chain extender 1,4-butanediol (BDO) as the hard segment Polyurethane (PU), elastic modulus 200-300MPa adjustment, elongation at break 300-500%; polylactic acid: PLGA (LA: GA=3:1), viscosity average molecular weight 100,000.

[0060] Collagen: It consists of one or a mixture of type I collagen or type III collagen.

[0061] Concrete preparation process is as follows:

[0062] (1) Prepare 5 g of polyurethane and 0.5 g of polylactic acid spinning solution: dissolve 5 g of polyurethane and 0.5 g of polylactic acid in 50 ml of a mixed solution of DMF and tetrahydrofuran (1:1), stir until completely dissolved, and obtain a mixed spinning solution...

Embodiment 3

[0065] Example 3: Preparation of a medical biofilm that induces cartilage regeneration

[0066] The ratio is polyurethane: polylactic acid: collagen, and its percentage by weight is 70%: 5%: 25%;

[0067] The polyurethane is: poly(ε-caprolactone) diol (PCL) as the soft segment, L-lysine diisocyanate (LDI) and chain extender 1,4-butanediol (BDO) as the hard segment Polyurethane (PU), elastic modulus 400-500MPa adjustment, elongation at break 700-1000%; polylactic acid: PLLA, viscosity average molecular weight 500,000; collagen type Ⅱ collagen.

[0068] Its preparation method is as follows:

[0069] (1) The joint defect is calculated and designed by computer and imported into the 3D printer. The injection-grade α-calcium sulfate hemihydrate is used to print the shape of the bone defect by 3D printing, and the motor at one end of the electrospinning equipment is inserted inside to form it by moisture curing.

[0070] (2) Preparation of collagen spinning solution: Dissolve colla...

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Abstract

The invention discloses a tissue induction biomedical material, and particularly relates to a degradable active biological membrane/powder. The tissue induction biomedical material is prepared from, by weight, 0.1-99% of degradable medical polyurethane, 0-99.9% of polyhydroxyalkanoate, 0-99.9% of polylactic acid and 1-99.9% of collagen, wherein polyhydroxyalkanoate is one of PHA, PHB, PHBV, PHBHHx and P3HB4HB, polylactic acid is one of polyglycolic acid and polylactic acid-glycolic acid copolymer, and collagen is one or more of collagen I, collagen II, collagen VI, collagen IX, collagen X, collagen XI and other various in-vivo collagen. The ratio of all the components is adjusted according to the requirements of the implanting positions of different in-vivo tissue for material performance, degradation products and PH values, so better clinical service is provided.

Description

technical field [0001] The invention belongs to the field of medical biomaterials and technology, in particular to a tissue-inducible biomedical material. Background technique [0002] Tissue-inducible biomedical materials can be designed through the material surface / interface composition and structure design with selective adsorption / adhesion to specific proteins and cells, and the tissue growth environment suitable for specific tissue formation and can regulate cell gene expression and differentiation pathways Designed to induce the regeneration of bone, skin, blood vessels, vascular intima, nerves, etc. The inducing effect of biomedical materials on tissue formation depends on the regulation of materials on protein and cell behavior. Gradual degradation of materials and eventually replacement of new tissue is the best result of tissue reconstruction. At the same time, the degradation of the material also involves the activation by the release of the adsorbed growth facto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/50A61L27/58A61L27/60D01F8/14D01F8/16D01F8/02
CPCA61L27/26A61L27/50A61L27/58A61L27/60A61L2430/06A61L2430/10A61L2430/22A61L2430/30D01F8/02D01F8/14D01F8/16C08L75/04C08L67/04
Inventor 张文芳
Owner YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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