21results about How to "Improve Medication Adherence" patented technology

The present application relates to the field of pharmaceutical preparations, in particular to a long-acting eye composite preparation for improving the symptoms of blepharitis. The preparation comprises a combination of two active ingredients in a therapeutically effective amount, and one or more ion-sensitive polymers or their complex systems, which are used to treat the symptoms of blepharitis caused by Demodex through a special double-cavity drug delivery bottle. By using a specific ion gel matrix concentration and regulating the viscosity of the drug solution before it reaches the eye, the limitations of traditional eye preparations are overcome, the retention time of the drug in the eye is prolonged, the bioavailability is improved, the probability of adverse events is reduced, and the medication compliance is increased.

The invention discloses a programmed stepped release microneedle transdermal drug delivery patch as well as a preparation method and application thereof, and relates to the technical field of medicines. The microneedle transdermal drug delivery patch comprises: a flexible substrate; the microneedles are arranged on the flexible substrate, a first medicine carrying area, a second medicine carrying area and a third medicine carrying area which are sequentially arranged in the direction from the needle tip to the needle root of each microneedle are arranged in each microneedle, and the release speed of the medicine in the first medicine carrying area, the release speed of the medicine in the second medicine carrying area and the release speed of the medicine in the third medicine carrying area are sequentially decreased. The invention provides a microneedle transdermal drug delivery patch with the functions of multilayer material construction, spatial partition drug loading, programmed stepped release and single-time application multi-stage drug delivery as well as a preparation method and application of the microneedle transdermal drug delivery patch. And a drug-loaded storage with clear spatial distribution is formed in the microneedle, so that the drug-loaded release sequence corresponds to the position of the microneedle structure, and programmed stepped release of the drug-loaded in the time dimension is realized.

This invention discloses a method for medication risk warning and dynamic intervention using a smart pillbox for elderly patients with chronic diseases, relating to the fields of intelligent medical devices and chronic disease management technology. The method first constructs four types of chronic disease knowledge graphs: medication behavior, physiological indicators, drug interactions, and environmental conditions. Then, it processes the graphs using a GNN module with a GRU-like gating mechanism, weightedly fusing multi-time-step features using a time-step attention mechanism, and integrating similar patient features based on Jaccard similarity to generate comprehensive risk features. During the training phase, the risk level and type are output after feature optimization using a collaborative attention mechanism. In the inference phase, a similarity propagation mechanism is used to address the cold-start problem for newly enrolled patients, matching a three-level intervention rule base to generate personalized strategies, and iteratively optimizing the model based on intervention feedback. This invention achieves proactive and precise warning and dynamic intervention, improving risk assessment performance and patient medication adherence in different scenarios.

This invention provides a method for preparing a metformin compound hypoglycemic oral solution, relating to the pharmaceutical field, comprising: step S1, pretreatment of traditional Chinese medicine components; step S2, enzymatic hydrolysis of the first group of traditional Chinese medicine components; step S3, supercritical extraction; step S4, preparation of mixed traditional Chinese medicines; step S5, preparation of inclusion complex; step S6, compound formulation; and step S7, post-processing. This method synergistically combines extracts from seven traditional Chinese medicines—bitter melon, phellodendron bark, astragalus root, kudzu root, rehmannia root, ginseng, and privet fruit—with metformin hydrochloride to form a metformin compound hypoglycemic oral solution, balancing the synergy, safety, and stability of traditional Chinese and Western medicines, thereby improving hypoglycemic effects while reducing the incidence of gastrointestinal adverse reactions to metformin.

The invention discloses a traditional Chinese medicine formula for treating idiopathic pulmonary fibrosis and a preparation method of the traditional Chinese medicine formula, the traditional Chinese medicine formula consists of twelve raw material medicines in specific parts by weight: radix glehniae, radix ophiopogonis, astragalus membranaceus, codonopsis pilosula, selfheal, oyster, processed pinellia ternate, edible tulip, seaweed, concha meretricis seu cyclinae, rhizoma sparganii and curcuma zedoary. The composition can effectively inhibit fibroblast proliferation and activation and reduce extracellular matrix secretion, and can play an anti-fibrosis role by inhibiting TNF-alpha inflammatory factors and NF-kappa B signal pathways, clinical tests show that the composition can significantly improve clinical symptoms of patients and delay lung function decline, and is good in safety and suitable for clinical application. The invention also provides a preparation method of the composition, various dosage forms such as decoction, granules, freeze-dried powder and the like can be prepared, the preparation process is simple and convenient, the composition is suitable for industrial production, and a safe and effective new traditional Chinese medicine treatment choice is provided for idiopathic pulmonary fibrosis.

The invention discloses a Yianning pill preparation method combining network pharmacology and a membrane enrichment process, and belongs to the technical field of traditional Chinese medicine preparation. The method comprises the following steps: predicting and determining a core medicinal component group related to the treatment of the coronary heart disease by the Yianning pill through network pharmacology, dividing prescription medicinal materials into a water-soluble component group and a fat-soluble and alcohol-soluble component group according to physicochemical properties of the medicinal component group, and carrying out partial extraction by adopting solvents with different polarities to obtain an extracting solution; enriching and refining the extracting solution by adopting a membrane separation technology such as microfiltration and ultrafiltration to obtain a medicinal component concentrated solution, and finally mixing the medicinal component concentrated solution with medicinal auxiliary materials to prepare the Yianning pill. According to the invention, through a membrane enrichment process, the concentration of medicinal components is effectively improved, the residue of ineffective impurities is reduced, the single dose is reduced, and the medication compliance of a patient is improved; and meanwhile, full extraction and retention of medicinal components with different properties are ensured by a subsection extraction strategy, and damage to heat-sensitive components is avoided.

This invention provides a pharmaceutical composition containing hezemibrate and an HMG-CoA reductase inhibitor, and may further include one or more excipients selected from calcium carbonate, butylated hydroxyanisole, butylated hydroxytoluene, citric acid, sodium lauryl sulfate, polysorbate, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, hydroxypropyl cellulose, lactose, pregelatinized starch, magnesium stearate, and talc. This composition can be formulated into various dosage forms, exhibiting good formulation stability and controllable quality.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition suitable for type II diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 45 parts of radix astragali seu hedysari, 20 to 30 parts of herba dendrobii, 30 to 45 parts of rhizoma polygonati, 20 to 30 parts of radix ophiopogonis and 20 to 30 parts of corn stigma. According to the traditional Chinese medicine composition, through the synergistic effect of core components such as astragalus membranaceus for tonifying qi, lifting yang, promoting salivation and nourishing blood, dendrobium nobile for tonifying stomach and promoting salivation, polygonatum kingianum for tonifying qi, nourishing yin, moistening lung and tonifying kidney, radix ophiopogonis for nourishing yin and promoting salivation and the like, glucose metabolism balance is effectively adjusted, insulin resistance is improved, and therefore the effect of reducing blood glucose and / or lipid is achieved.

The utility model relates to eye drops propaganda technology field discloses intelligent eye -dabbing propaganda box, including a plurality of eye drops bottles with eye drops and support subassembly, and the upper end of support subassembly is provided with electric control assembly part, and the outside of electric control assembly part is provided with the mainboard protection subassembly for protecting electric control assembly part, and the inside of mainboard protection subassembly is provided with the storage subassembly for a plurality of eye drops bottles storage, and the box still innovatively introduces bar code identification technology to the intelligent eye -dabbing, and the device can rapidly identify the kind, the use method and the key information such as the matters needing attention of eye drops of bar code on the eye drops bottle, and more personalized, accurate medicine guide is provided for the patient, and this design not only greatly promotes the convenience and accuracy of medicine, but also helps to improve the medicine compliance and treatment effect of patient, and the device structure is small and is convenient for carrying.

The invention discloses a human epidermal growth factor temperature-sensitive sustained-release gel as well as a preparation method and application thereof, and belongs to the technical field of biological pharmacy. The preparation method of the human epidermal growth factor temperature-sensitive sustained-release gel comprises the following steps: S1, adding poloxamer and a thickening agent into purified water, and uniformly mixing to form a gel matrix; s2, respectively preparing a human epidermal growth factor solution and a chitosan-sodium tripolyphosphate colloid, and adding the human epidermal growth factor solution into the chitosan-sodium tripolyphosphate colloid for adsorption to obtain the chitosan-sodium tripolyphosphate colloid loaded with the human epidermal growth factor; s3, adding the chitosan-sodium tripolyphosphate colloid loaded with the human epidermal growth factors, a humectant and a stabilizer into the gel matrix, and adjusting the pH value. The gel can realize stable loading and controllable slow release of the human epidermal growth factor, so that the administration frequency and repeated administration operation are reduced, and the gel has important application value in treatment of refractory wounds.

This application relates to the biomedical field and discloses a predictive model and validation method for ART virological failure in HIV / AIDS patients. The model construction method includes the following steps: S1, collecting clinical data from HIV or AIDS patients; S2, performing multiple imputation processing on the clinical data to generate multiple datasets; S3, using a stepwise regression method to screen predictive factors in each dataset; S4, synthesizing the datasets to determine the final predictive factors; S5, establishing a virological failure prediction model based on the final predictive factors. The predictive model constructed by this invention can serve as an effective tool for predicting the risk of ART virological failure in HIV or AIDS patients in clinical practice. The application of this model helps improve treatment effectiveness, optimize resource allocation, and ultimately improve patient treatment outcomes. Furthermore, by continuously collecting new patient data and re-evaluating model performance, the accuracy and practicality of the model can be further improved.

This application discloses a reminder method, device, electronic device, and computer-readable storage medium, relating to the field of health management technology. The method includes: determining the proximity of a user's medication anchor point based on the location of the target medication and the user's location; predicting the risk of medication unavailability based on the target medication's dosing plan, the user's historical outing patterns, calendar busyness, historical medication carrying success rate, and proximity to the medication anchor point; predicting a target medication preparation time window based on the distance between the user and the medication anchor point, the user's busyness level, and current activity status; continuously monitoring the real-time distance between the user and the medication anchor point, and the user's real-time busyness within the target medication preparation time window; and pushing a medication preparation reminder to the user when the real-time distance is less than a distance threshold and the real-time busyness is less than a busyness threshold for a specified duration. Thus, this solution ensures that the medication is readily available to the user when the scheduled dosing time arrives.

The present application provides a kind of micro tablet, it includes the compound shown in formula I, filler and optionally pharmaceutically acceptable adjuvant, wherein, the diameter of the micro tablet is 1 ~ 3mm, the ratio of diameter and thickness is 0.6 ~ 1.2, the tablet weight is 2.5 ~ 10mg, and includes 1 ~ 5mg compound shown in formula I.The present application also provides the preparation method and pharmaceutical use of the micro tablet.The micro tablet of the present application can realize small dose direct precision dosing, easy to use;It is easy to swallow, can effectively improve the problem of poor palatability of cholic acid drugs, improve medication compliance;It can realize the effect of consistent dissolution characteristics of different doses, ensure the stability of treatment effect under different doses;It can reduce the use of adjuvant, avoid the safety problem of children medication;High stability, conducive to storage and transportation, improve the safety of use;High bioavailability, can more effectively realize in vivo absorption and utilization;Effectively solve the content uniformity problem, reduce the difficulty of process, more suitable for industrial production.

This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a Qi-invigorating and blood-activating granule for heart pain and its preparation method, comprising the following raw materials in parts by weight: 25-35 parts of raw Astragalus membranaceus, 10-20 parts of Angelica sinensis, 5-15 parts of ginseng, 4-8 parts of Panax notoginseng, 10-20 parts of Ligusticum chuanxiong, 8-12 parts of earthworm, and 2-4 parts of leech. This invention precisely targets the core pathogenesis of Qi deficiency and blood stasis syndrome, which is "Qi deficiency as the root and blood stasis as the manifestation," selecting raw Astragalus membranaceus and ginseng as the core Qi-invigorating components, and Panax notoginseng, leech, Ligusticum chuanxiong, Angelica sinensis, and earthworm as the core blood-activating components. The formulation follows the traditional Chinese medicine principle of "invigorating Qi to promote blood circulation without harming the body's vital energy." The dosage of each raw material has been optimized through systematic experiments to form a specific range of parts by weight, solving the technical problems of poor targeting and insufficient synergy in existing formulations.

This application discloses a method, apparatus, electronic device, and storage medium for processing medication purchase behavior data, relating to the field of data management technology. The method includes: collecting historical medication purchase behavior data of users; determining a continuous sequence of user medication use states based on the historical medication purchase behavior data; encoding the historical medication purchase behavior data, contextual features, and user tags using an attention model to obtain user behavior temporal features; and determining the user's implicit medication use state information based on the continuous sequence of medication use states and the user behavior temporal features. The implicit medication use state information includes at least the probability distribution information of the user's various medication use states. This application solves the problem in existing technologies that primarily rely on physiological monitoring indicators or single-action rules to predict a user's medication use state, resulting in low accuracy in predicting the user's medication use state and consequently failing to guarantee accurate reminders to users to purchase or take medication in a timely manner.

The embodiment of the application provides a voice reminding system of a medicine inhaler and an inhaler thereof. The terminal is configured to record personalized voice reminding information of a user by configuring medicine reminding information, and sends the medicine reminding configuration information and the personalized voice reminding information to the inhaler. The control unit of the inhaler dynamically plays the customized voice prompt, solves the problem that the static operation guide in the prior art cannot adapt to patients with different cognitive levels, can provide clear and easy-to-understand voice guidance according to individual needs of the patient, and effectively improves operation accuracy and medicine compliance.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a treprostinil soluble microcrystalline patch and a preparation method thereof. Existing treprostinil mainly depends on intravenous injection or subcutaneous injection, the administration mode needs to be operated by professional medical staff, pain is brought to a patient, and the problems of infection risk, inconvenience in long-term administration and the like exist. The invention provides a treprostinil soluble microcrystalline patch and a preparation method thereof. The patch is of a layered structure and comprises a backing layer, a microcrystal array layer, an adhesive layer and a protective layer, and the microcrystal array layer is composed of treprostinil, a biodegradable polymer matrix material and auxiliary materials. The preparation method comprises the following steps: dissolving the components in a solvent to form a microcrystal stock solution, injecting into a mold, curing microcrystals through vacuum drying, and laminating and assembling with each layer of material. The microcrystalline patch disclosed by the invention can penetrate through a skin cuticle painlessly and noninvasively, so that efficient and continuous transdermal administration of treprostinil is realized, and many defects of an existing administration mode of treprostinil are overcome.

The application provides a compound omeprazole dry suspension and a preparation method thereof, and relates to the technical field of pharmaceutical preparations.The compound omeprazole dry suspension comprises the following raw materials: omeprazole, sodium bicarbonate, magnesium silico-aluminate, hard stearic acid modified hydrotalcite, low acyl gellan gum, hydroxypropyl methyl cellulose and trehalose.The application provides a compound omeprazole dry suspension and a preparation method thereof, and the compound omeprazole dry suspension with specific particle size is prepared through specific proportioning of auxiliary materials and a specific preparation process, and the stability and solubility are significantly improved.

The present invention discloses a calcium levofolinate oral tablet for improving children's symptoms of FRAs positive autism spectrum disorder, and relates to the technical field of pharmaceutical preparations, the calcium levofolinate oral tablet comprises: a quick release layer, the quick release layer contains calcium levofolinate, a first disintegrating agent and a first filler; the sustained release-positioning release layer contains calcium levofolinate, a gastrointestinal adhesion material and a pH sensitive polymer, and the pH sensitive polymer is dissolved or swelled in an environment with the pH being greater than or equal to 6.0; the isolating layer is positioned between the quick release layer and the slow release-positioning release layer, and the isolating layer is made of a material which is insoluble in gastric juice but can be quickly dissolved in intestinal juice; the outer layer of the oral tablet is coated with a taste masking film; the technical problems that in the prior art, medicine absorption is unstable, the blood concentration fluctuation is large, a personalized precise administration scheme is lacked, and the medication compliance of child patients is poor are solved.

The invention discloses ROS (reactive oxygen species)-responsive macrophage-targeted 4OI-loaded hydrogel microspheres, a microneedle dressing, a preparation method of the ROS-responsive macrophage-targeted 4OI-loaded hydrogel microspheres and the microneedle dressing and novel medical application of the ROS-responsive macrophage-targeted 4OI-loaded hydrogel microspheres and the microneedle dressing in burn wounds, and belongs to the technical According to the adopted scheme, PLGA-TK-PEG-COOH is used as a carrier, 4OI is entrapped through a microemulsion ultrasonic method, and then mannose is connected through an amidation reaction for surface modification. According to the hydrogel microspheres, ROS response accurate drug release is realized by virtue of TK bonds, and advanced leakage of drugs is avoided; mannose can target a macrophage surface receptor, so that the delivery accuracy is improved. The hydrogel has the characteristics of high encapsulation efficiency, high ROS response and release at the diseased region, excellent biocompatibility of the used materials, and simple and controllable preparation process. The 4OI delivery system can be widely applied to treatment of related diseases such as inflammation and tumors, can also be compounded to prepare a microneedle dressing to realize local deep administration, effectively solves the pain points of poor targeting property, large toxic and side effects and the like of the existing 4OI delivery system, and has important clinical application value and industrialization prospect.

The invention belongs to the technical field of pharmacy, and particularly relates to minoxidil liniment as well as a preparation method and application thereof. The minoxidil liniment comprises the following components: minoxidil, an alcoholic solution, a stabilizer, an oat extract and water, wherein the stabilizer comprises EDTA (Ethylene Diamine Tetraacetic Acid)-tetrasodium, panthenol and hydroxypropyl cellulose. By utilizing the synergistic effect of the EDTA-tetrasodium, the panthenol and the hydroxypropyl cellulose, the preparation process is optimized, so that the effectiveness and the stability of the minoxidil serving as the raw material medicine can be effectively improved, the validity period of the minoxidil can be prolonged, and the medication compliance can be improved. According to the liniment disclosed by the invention, the oat extract is adopted as an auxiliary material of the liniment, so that side effects of minoxidil are reduced, red and swollen, pruritus and discomfort possibly caused by minoxidil can be effectively relieved, damaged scalp skin barriers are helped to be repaired, microinflammation around hair follicles is reduced, and a healthier environment is created for hair growth.