55results about How to "Improve Medication Adherence" patented technology

The invention discloses a polypeptide derivative with a GCGR, GIPR and GLP-1R triple targeting agonistic effect as well as a preparation method and application of the polypeptide derivative, the polypeptide derivative is shown as a formula (I), (II) is a branched chain modification structure of a peptide chain, and the group definition is detailed in the specification. The polypeptide derivative compound and the pharmaceutically acceptable salt thereof provided by the invention can be used for treating metabolic related diseases such as diabetes mellitus, weight loss, MASH and the like, cardiovascular and cerebrovascular diseases and / or neurodegenerative diseases. Tyr-Aib-Gln-Gly-Thr-Ph-Thr-Ser-Asp-Tyr-Ser-Xaa12-Xaa13-Leu-As-Lys-Xaa17-Ala-Gln-Xaa24-Xaa25-Leu-Leu-Xaa28-Gly-Ala-Pro-Pro-Ser-NH2 (I) # imgabs0 #

According to the nitrogen hydrochloride # imgabs0 # stine eye drops for treating allergic conjunctivitis and the preparation method of the nitrogen hydrochloride # imgabs0 # stine eye drops, the prepared eye drops can interact with the mucous layer on the surface of keratoconjunctiva by selecting specific solid lipid and a surfactant and controlling the dosage of the solid lipid and the surfactant; the retention capacity of the medicine in front of the cornea is prolonged, so that the medicine has good targeting property, the continuous release of the medicine is realized, the medication frequency can be reduced, the toxic and side effects of the medicine are reduced, the bioavailability is improved, the medication compliance of a patient is enhanced, and in the preparation and long-term storage processes, the medicine has better stability, and is suitable for popularization and application. Therefore, the problems of excessive drug due to multiple administration and poor stability of the active component nitrogen hydrochloride # imgabs1 # stine are solved.

The invention provides an oral cavity soluble film solution based on a nano-carrier and a preparation method of an oral cavity soluble film. According to the method, a nano-carrier technology, microcapsule multilayer coating, a low-temperature electrochemical polymerization method and an ultrasonic dispersion technology are utilized, and uniform distribution and multi-stage slow release of a medicine in an oral instant film are achieved. According to the invention, active pharmaceutical ingredients are firstly wrapped by a nano-carrier, and then a multi-layer composite coating structure is formed by a microcapsule technology, so that drug release effects at different stages are realized. And then, uniformly mixing the microcapsule nano-drug particles with a film-forming substrate, depositing layer by layer to form a film through a low-temperature electrochemical polymerization method, and carrying out low-temperature drying treatment. The soluble film disclosed by the invention has good biocompatibility and mechanical strength, and can be gradually dissolved in an oral cavity, and the medicine is released according to a set stage, so that a long-acting oral care or treatment effect is realized. The method avoids the use of high temperature and organic solvents, is environment-friendly and safe, and is suitable for delivery systems of various oral drugs.

The invention discloses a ketotifen fumarate divided-dose tablet based on a 3D printing technology and a preparation method thereof. The ketotifen fumarate clinical divided-dose tablet comprises the following components in percentage by mass: 1-10% of ketotifen fumarate tablet powder, 90-99% of cocoa butter and 0-5% of a flavoring agent, and the sum of the mass percentages of the components is equal to 100%. According to the technical scheme, a hot-melt extrusion type 3D printing technology is adopted to achieve rapid dissolution and clinical precise dose division of tablets, the 3D printing technology is applied to the field of dose division of commercially available tablets, and tablet powder and heated and melted pharmaceutic adjuvants are evenly mixed to prepare a printing material; the dose of the 3D printing divided dose tablet is accurately controlled by adjusting the drug content of the printing material and the volume of the printing model; the content of medicines in commercially available tablets is diluted by adding pharmaceutic adjuvants, and small-dose tablets with lower content are prepared again, so that precise dose-divided administration is realized, and the purpose of individualized administration is achieved.

The invention discloses a novel administration method for eye administration. The novel administration method specifically comprises the following steps: S1, filling a special solution bottle with a drug solution; s2, the solution bottle is aligned with the eyes to be used in the spraying process, medicine fog drops enter the eye liquid medicine bottle to be combined with an atomization device to be used, fine fog-shaped liquid drops are sprayed out through the atomization device, the particle size of the fog drops ranges from 0.1 micrometer to 60 micrometers, and the fog drops reach eyeballs and the peripheries of the eyes; s3, administration is performed in a medicine and mechanical combination mode during use, the medicine solution and the atomization device can be separately produced and prepared, and the medicine solution and the atomization device are combined during use. According to the novel administration method and atomization administration mode for eye administration, the medication treatment effect can be improved, the risk of eye infection caused by drugs is reduced, the discomfort of eyes during medication is improved, and the medication compliance of patients is improved.

The present application relates to the field of pharmaceutical preparations, in particular to a long-acting eye composite preparation for improving the symptoms of blepharitis. The preparation comprises a combination of two active ingredients in a therapeutically effective amount, and one or more ion-sensitive polymers or their complex systems, which are used to treat the symptoms of blepharitis caused by Demodex through a special double-cavity drug delivery bottle. By using a specific ion gel matrix concentration and regulating the viscosity of the drug solution before it reaches the eye, the limitations of traditional eye preparations are overcome, the retention time of the drug in the eye is prolonged, the bioavailability is improved, the probability of adverse events is reduced, and the medication compliance is increased.

The invention discloses a uremia clearing liquid preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The uremia clearing liquid preparation is prepared from the following raw materials: rheum officinale, astragalus membranaceus, white mulberry root-bark, radix sophorae flavescentis, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, radix polygoni multiflori preparata, radix paeoniae alba, salvia miltiorrhiza, ligusticum wallichii, chrysanthemum, ginger processed pinellia, plantain herb, radix bupleuri, liquorice, a disodium hydrogen phosphate-citric acid buffer solution, beta-cyclodextrin, tween-80, xanthan gum, stevioside and water. By improving the preparation process and providing a new auxiliary material system, the stability of the oral liquid preparation is improved, the transfer rate of effective components is increased, the flavor is improved, and the palatability is improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating psoriasis as well as a preparation method and application thereof. The traditional Chinese medicine composition for treating psoriasis is characterized by being prepared from the following raw materials in parts by weight: 2 to 16 parts of radix gentianae macrophyllae, 4 to 11 parts of radix sophorae flavescentis, 14 to 31 parts of herba hedyotidis diffusae, 14 to 31 parts of caulis lonicerae, 9 to 16 parts of caulis spatholobi and 9 to 16 parts of ramulus uncariae cum uncis. The traditional Chinese medicine composition for treating psoriasis not only plays a local treatment role through mechanisms of penetrating through striae and interstices, relaxing meridians, regulating qi and blood, expelling evil and strengthening body resistance and the like, but also penetrates into viscera through skin hair orifices to play a role of internal and external combined treatment. The traditional Chinese medicine composition is simple and convenient to use, convenient to carry and easy to popularize, the medication compliance of patients is effectively improved, and a guarantee is provided for the continuity of psoriasis treatment.

The invention belongs to the technical field of Chinese medicine preparation, and specifically is a preparation method and application of a Chinese medicine preparation for treating hypertension complicating pregnancy. The method comprises the following steps: washing and drying Chinese medicinal materials in a prescribed amount, crushing them respectively, and mixing them uniformly to obtain a mixed powder A; soaking the remaining components in water according to the prescribed amount, decocting, filtering, and concentrating to obtain a Chinese medicine extract with a relative density; putting the obtained extract into a vacuum dryer for fluidized drying, and crushing them to obtain a mixed powder B after combined operation; and mixing the mixed powder A and the mixed powder B uniformly and sealing them for storage to obtain a finished product, so as to give full play to the efficacy of each medicine and avoid the loss of efficacy, so as to achieve a high release rate of the effective ingredients of the medicine, and significantly improve the stability and solubility of the medicine, thereby improving the therapeutic effect and cure rate of the medicine.

The invention relates to siRNA (small interfering Ribonucleic Acid) for regulating expression of angiotensinogen AGT, a conjugate and a pharmaceutical composition of the siRNA and application of the siRNA. The siRNA comprises a positive-sense strand and an antisense strand, each nucleotide in the siRNA is independently modified or unmodified nucleotide, the positive-sense strand contains a nucleotide sequence I, the antisense strand contains a nucleotide sequence II, and the nucleotide sequence I and the nucleotide sequence II are at least partially reversely complementary to form a double-strand region. The siRNA, the conjugate thereof and the pharmaceutical composition provided by the invention can effectively regulate the expression of angiotensinogen AGT.

The invention relates to the technical field of medical treatment, in particular to a traditional Chinese medicine personalized diagnosis and treatment scheme generation method which comprises the steps of obtaining medical record data related to traditional Chinese medicine from multiple sources, analyzing the medical record data to obtain potential association rule data, and establishing a corresponding traditional Chinese medicine knowledge graph based on the association rule data; health data of a patient are obtained, corresponding diagnosis and treatment suggestion data are generated based on the traditional Chinese medicine knowledge graph and the health data, and the health data comprise symptoms and physique of the patient; and sending the health data and the corresponding diagnosis and treatment suggestion data to different user sides, obtaining diagnosis and treatment feedback data of each user side, optimizing the diagnosis and treatment suggestion data based on all the diagnosis and treatment feedback data, and determining a corresponding target diagnosis and treatment scheme. The traditional Chinese medicine diagnosis and treatment effect can be improved.

The invention discloses an iron maltol-oxalic acid eutectic crystal which is formed by taking iron maltol as a medicinal active component and oxalic acid as a eutectic crystal ligand and adopting a suspension stirring method. In an X-ray powder diffraction pattern obtained through Cu-K alpha radiation measurement, the iron maltol-oxalic acid eutectic crystal has characteristic diffraction peaks at the diffraction angles 2 theta of about 14.7 + / -0.2 degrees, 17.0 + / -0.2 degrees, 17.6 + / -0.2 degrees, 24.8 + / -0.2 degrees, 26.6 + / -0.2 degrees and 26.9 + / -0.2 degrees. The iron maltol-oxalic acid eutectic crystal is good in stability, and does not generate crystal transformation in at least 60 days under an accelerated condition. Compared with iron maltol, the iron maltol-oxalic acid eutectic has the advantages that the solubility of the iron maltol-oxalic acid eutectic in water is relatively low, the dissolution rate of the eutectic with low solubility is generally low, the drug concentration peak value in a short time can be avoided, the toxic and side effects of the iron maltol are reduced, and the medication compliance is improved.

The present invention relates to a composition containing Antrodia cinnamomea powder and a preparation method and application thereof, belonging to the technical field of medicines, the composition comprises Antrodia cinnamomea extract, Hovenia dulcis extract, Pueraria root extract, Psoralea corylifolia extract, Cyperus rotundus extract and cotton sugar; Antrodia cinnamomea extract contains triterpenoid compounds; Pueraria root extract is an extract below 10kDa obtained by graded enzymolysis of Pueraria root with hemicellulase and trypsin; Psoralea corylifolia extract is an extract below 5kDa obtained by enzymolysis of Psoralea corylifolia protein with alkaline protease; Cyperus rotundus extract is an extract below 5kDa obtained by enzymolysis of Cyperus rotundus with subtilisin and trypsin. Pueraria root extract, Psoralea corylifolia extract and Cyperus rotundus extract all have the effect of promoting hangover, and have a significant synergistic effect when used in combination with Antrodia cinnamomea extract, can promote cell and enzyme activity, promote the decomposition of alcohol in the body, quickly improve the drunken state, and do not cause vomiting.

The invention discloses a programmed stepped release microneedle transdermal drug delivery patch as well as a preparation method and application thereof, and relates to the technical field of medicines. The microneedle transdermal drug delivery patch comprises: a flexible substrate; the microneedles are arranged on the flexible substrate, a first medicine carrying area, a second medicine carrying area and a third medicine carrying area which are sequentially arranged in the direction from the needle tip to the needle root of each microneedle are arranged in each microneedle, and the release speed of the medicine in the first medicine carrying area, the release speed of the medicine in the second medicine carrying area and the release speed of the medicine in the third medicine carrying area are sequentially decreased. The invention provides a microneedle transdermal drug delivery patch with the functions of multilayer material construction, spatial partition drug loading, programmed stepped release and single-time application multi-stage drug delivery as well as a preparation method and application of the microneedle transdermal drug delivery patch. And a drug-loaded storage with clear spatial distribution is formed in the microneedle, so that the drug-loaded release sequence corresponds to the position of the microneedle structure, and programmed stepped release of the drug-loaded in the time dimension is realized.

This invention discloses a method for medication risk warning and dynamic intervention using a smart pillbox for elderly patients with chronic diseases, relating to the fields of intelligent medical devices and chronic disease management technology. The method first constructs four types of chronic disease knowledge graphs: medication behavior, physiological indicators, drug interactions, and environmental conditions. Then, it processes the graphs using a GNN module with a GRU-like gating mechanism, weightedly fusing multi-time-step features using a time-step attention mechanism, and integrating similar patient features based on Jaccard similarity to generate comprehensive risk features. During the training phase, the risk level and type are output after feature optimization using a collaborative attention mechanism. In the inference phase, a similarity propagation mechanism is used to address the cold-start problem for newly enrolled patients, matching a three-level intervention rule base to generate personalized strategies, and iteratively optimizing the model based on intervention feedback. This invention achieves proactive and precise warning and dynamic intervention, improving risk assessment performance and patient medication adherence in different scenarios.

The invention belongs to the technical field of medicines, and particularly relates to application of agastache rugosus stomach-soothing powder in hangover alleviating and preparation of products for preventing and / or treating liver-stomach injury caused by alcohol. The wrinkled gianthyssop herb stomach-soothing powder has a remarkable protection effect on alcohol-induced acute drunkenness and related liver and stomach injuries, and the protection effect is related to ethanol metabolism enhancement, oxidation resistance improvement, lipid peroxidation reduction and inflammatory reaction inhibition of the wrinkled gianthyssop herb stomach-soothing powder. The composition of the agastache rugosus stomach-soothing powder has relatively high dosage efficiency and synergistic effect, plays a role in multiple aspects, and provides more comprehensive protection.

This invention provides a method for preparing a metformin compound hypoglycemic oral solution, relating to the pharmaceutical field, comprising: step S1, pretreatment of traditional Chinese medicine components; step S2, enzymatic hydrolysis of the first group of traditional Chinese medicine components; step S3, supercritical extraction; step S4, preparation of mixed traditional Chinese medicines; step S5, preparation of inclusion complex; step S6, compound formulation; and step S7, post-processing. This method synergistically combines extracts from seven traditional Chinese medicines—bitter melon, phellodendron bark, astragalus root, kudzu root, rehmannia root, ginseng, and privet fruit—with metformin hydrochloride to form a metformin compound hypoglycemic oral solution, balancing the synergy, safety, and stability of traditional Chinese and Western medicines, thereby improving hypoglycemic effects while reducing the incidence of gastrointestinal adverse reactions to metformin.

The invention provides an amoxicillin preparation and a preparation method thereof, and the preparation method comprises the following steps: preparing a temperature-sensitive polymer solution, uniformly mixing amoxicillin powder with chitosan and pretreated lactose, adding the mixture into the temperature-sensitive polymer solution, and carrying out spray drying to form amoxicillin-polymer composite particles, and carrying out multi-layer temperature sensitive coating treatment and curing. According to the invention, by using the temperature-sensitive polymer PNIPAM, the drug can be quickly released at an inflammation part under a high-temperature condition, the drug effect is improved, and the side effect is reduced. Due to the addition of the chitosan and the pretreated lactose, the solubility and bioavailability of the amoxicillin are improved, and the uniform distribution and sustained release of the medicine are ensured. The use of the plasticizer glycerol enhances the flexibility and stability of the polymer, and through curing treatment, the stability of the coating layer and the controllability of drug release are improved. The amoxicillin preparation disclosed by the invention has remarkable advantages in the aspects of improving the curative effect, reducing the side effect and improving the compliance of a patient.

The invention discloses a traditional Chinese medicine formula for treating idiopathic pulmonary fibrosis and a preparation method of the traditional Chinese medicine formula, the traditional Chinese medicine formula consists of twelve raw material medicines in specific parts by weight: radix glehniae, radix ophiopogonis, astragalus membranaceus, codonopsis pilosula, selfheal, oyster, processed pinellia ternate, edible tulip, seaweed, concha meretricis seu cyclinae, rhizoma sparganii and curcuma zedoary. The composition can effectively inhibit fibroblast proliferation and activation and reduce extracellular matrix secretion, and can play an anti-fibrosis role by inhibiting TNF-alpha inflammatory factors and NF-kappa B signal pathways, clinical tests show that the composition can significantly improve clinical symptoms of patients and delay lung function decline, and is good in safety and suitable for clinical application. The invention also provides a preparation method of the composition, various dosage forms such as decoction, granules, freeze-dried powder and the like can be prepared, the preparation process is simple and convenient, the composition is suitable for industrial production, and a safe and effective new traditional Chinese medicine treatment choice is provided for idiopathic pulmonary fibrosis.

The invention relates to a dexmedetomidine microneedle patch as well as a preparation method and application thereof. The dexmedetomidine microneedle patch comprises a substrate and a needle body arranged on the surface of the substrate, wherein the needle body comprises dexmedetomidine hydrochloride, a framework material and a penetration enhancer; the penetration enhancer is prepared from one or more of dodecyl-beta-D-maltoside, ethylenediamine tetraacetic acid and tetrahydropiperine. The dexmedetomidine microneedle patch is higher in medicine cumulative penetration amount, facilitates shortening of sleep-aiding onset time and prolonging of sleep-aiding action time, and has a good insomnia treatment effect.

The invention discloses a Yianning pill preparation method combining network pharmacology and a membrane enrichment process, and belongs to the technical field of traditional Chinese medicine preparation. The method comprises the following steps: predicting and determining a core medicinal component group related to the treatment of the coronary heart disease by the Yianning pill through network pharmacology, dividing prescription medicinal materials into a water-soluble component group and a fat-soluble and alcohol-soluble component group according to physicochemical properties of the medicinal component group, and carrying out partial extraction by adopting solvents with different polarities to obtain an extracting solution; enriching and refining the extracting solution by adopting a membrane separation technology such as microfiltration and ultrafiltration to obtain a medicinal component concentrated solution, and finally mixing the medicinal component concentrated solution with medicinal auxiliary materials to prepare the Yianning pill. According to the invention, through a membrane enrichment process, the concentration of medicinal components is effectively improved, the residue of ineffective impurities is reduced, the single dose is reduced, and the medication compliance of a patient is improved; and meanwhile, full extraction and retention of medicinal components with different properties are ensured by a subsection extraction strategy, and damage to heat-sensitive components is avoided.

This invention provides a pharmaceutical composition containing hezemibrate and an HMG-CoA reductase inhibitor, and may further include one or more excipients selected from calcium carbonate, butylated hydroxyanisole, butylated hydroxytoluene, citric acid, sodium lauryl sulfate, polysorbate, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, hydroxypropyl cellulose, lactose, pregelatinized starch, magnesium stearate, and talc. This composition can be formulated into various dosage forms, exhibiting good formulation stability and controllable quality.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition suitable for type II diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 45 parts of radix astragali seu hedysari, 20 to 30 parts of herba dendrobii, 30 to 45 parts of rhizoma polygonati, 20 to 30 parts of radix ophiopogonis and 20 to 30 parts of corn stigma. According to the traditional Chinese medicine composition, through the synergistic effect of core components such as astragalus membranaceus for tonifying qi, lifting yang, promoting salivation and nourishing blood, dendrobium nobile for tonifying stomach and promoting salivation, polygonatum kingianum for tonifying qi, nourishing yin, moistening lung and tonifying kidney, radix ophiopogonis for nourishing yin and promoting salivation and the like, glucose metabolism balance is effectively adjusted, insulin resistance is improved, and therefore the effect of reducing blood glucose and / or lipid is achieved.

The invention discloses a medicine reminding device convenient for the elderly to carry during outdoor activities, which relates to the field of medicine taking reminding and comprises a data processing unit, and a storage unit, an input / output unit, a communication unit and a sensor unit which are electrically connected with the data processing unit, the data processing unit determines a travel plan and a medication plan of the old and stores the plans to the storage unit; when the elderly go out, medicine carrying reminding information and medicine taking reminding information are sent out; the input and output unit sends a corresponding prompt to prompt the old to carry medicines or take medicines; the data processing unit sends guardian reminding information to the external equipment through the communication unit according to the medication plan when the elderly do not take the medicine according to the plan, and a guardian is reminded to intervene. The device is specially designed for the elderly, is convenient to carry, can provide medicine reminding anytime and anywhere, enhances medication compliance of the elderly, and ensures physical health of the elderly.

The invention discloses an asenapine maleate oral adhesion film preparation as well as a preparation method and application thereof, belongs to the field of pharmaceutical preparations, and particularly relates to an asenapine maleate self-nanoemulsion oral adhesion film and an asenapine maleate nanocrystal oral adhesion film preparation. The self-nanoemulsion can improve the solubility of asenapine maleate, the lower surface tension of the self-nanoemulsion is beneficial to penetrating through a mucous membrane hydration layer and enhancing mucous membrane absorption, and the nanocrystal can improve the solubility and dissolution rate of API, increase the drug concentration gradient near the oral mucosa and promote diffusion and oral absorption of drugs. The oral cavity adhesion film can adhere to the sublingual part and rapidly release the medicine, the medicine is absorbed by rich submucosal blood vessels and directly enters systemic circulation, metabolism of the gastrointestinal tract and the liver is avoided, and then oral bioavailability is enhanced.

The invention relates to the technical field of medicine bottles, and discloses an oral medicine quantitative medicine outlet bottle which comprises a medicine outlet mechanism and further comprises a moving mechanism and a bottle body mechanism, the side face of the medicine outlet mechanism is connected with the inner side of the bottle body mechanism, and the inner side of the medicine outlet mechanism is in threaded connection with the side face of the moving mechanism. The side face of the moving mechanism is fixedly connected with the bottom end of the bottle body mechanism, the medicine discharging mechanism comprises a medicine partition plate, the side face of the medicine partition plate is fixedly connected with a sealing ring, the side face of the sealing ring is connected with the inner side of the bottle body mechanism, the inner side of the medicine partition plate is fixedly connected with a fixing frame, and the bottom end of the fixing frame is fixedly connected with a fixing piece. A groove is formed in the top end of the medicine partition plate, so that it is guaranteed that the dosage is accurate when medicine is taken every time, dosage deviation caused by improper manual operation is avoided, and therefore the medicine use safety is improved; the high-density polyethylene has good corrosion resistance to various chemical substances and is not easy to react with medicine components, so that the effectiveness and the safety of the medicine are ensured.

The invention discloses a pentoxyverine citrate sustained-release dry suspension with a taste-masking effect and a preparation method thereof, and relates to the technical field of medicines, the sustained-release dry suspension comprises pentoxyverine citrate taste-masking sustained-release pellets, a suspending aid, a sweetening agent, a bacteriostatic agent and an aromatic; the preparation method comprises the following steps: firstly, preparing the pentoxyverine citrate taste-masking sustained-release pellets, and then uniformly mixing the pentoxyverine citrate taste-masking sustained-release pellets, the suspending aid, the sweetening agent, the bacteriostatic agent and the aromatic. By adopting the sustained-release framework material, the sustained-release effect is achieved, the medicine taking frequency is reduced, and the medicine taking compliance of a patient is improved.

The utility model relates to eye drops propaganda technology field discloses intelligent eye -dabbing propaganda box, including a plurality of eye drops bottles with eye drops and support subassembly, and the upper end of support subassembly is provided with electric control assembly part, and the outside of electric control assembly part is provided with the mainboard protection subassembly for protecting electric control assembly part, and the inside of mainboard protection subassembly is provided with the storage subassembly for a plurality of eye drops bottles storage, and the box still innovatively introduces bar code identification technology to the intelligent eye -dabbing, and the device can rapidly identify the kind, the use method and the key information such as the matters needing attention of eye drops of bar code on the eye drops bottle, and more personalized, accurate medicine guide is provided for the patient, and this design not only greatly promotes the convenience and accuracy of medicine, but also helps to improve the medicine compliance and treatment effect of patient, and the device structure is small and is convenient for carrying.

The invention discloses a composite nutritional agent for enriching blood and relieving exercise-induced fatigue of competitive animals, and belongs to the technical field of traditional Chinese veterinary medicines. The compound nutritional agent comprises the following components in percentage by weight: 0.1%-0.5% of ginseng powder, 64.0%-78.9% of acanthopanax, 10%-20% of mulberry powder, 5%-6% of algal oil DHA (docosahexaenoic acid), 3%-4% of taurine, 1.5%-2.5% of guanidinoacetic acid, 0.5%-1.0% of vitamin C, 0.5%-1.0% of vitamin B12 and 0.5%-1.0% of astaxanthin. Any one of ferrous gluconate, ferrous lactate and ferrous fumarate can also be added. The compound nutritional agent has the remarkable advantages of being long in lasting action time, free of residues, extremely small in irritation to animal bodies and the like.

The invention provides a novel composition comprising a deep eutectic solvent, a lipid material and a nucleic acid drug. The composition is a uniform and stable dispersion system. The administration mode of the composition is not limited to injection administration and can be selected from nasal administration, oral administration, sublingual administration, skin administration and the like. And the medication compliance of a patient using the nucleic acid medicine can be improved by virtue of more selected administration modes. The composition can significantly improve the delivery efficiency of nucleic acid drugs in vivo, especially in cavity mucous membranes and mucus.