87 results about "Taste masking" patented technology

The invention belongs to the technical field of medicine taste masking, and particularly relates to a traditional Chinese medicine taste-masking water-in-water Pickering emulsion, a microcapsule, a preparation method and application. A first polymer system aqueous solution in which a water-soluble bitter drug is dispersed and a second polymer system aqueous solution in which a particle stabilizer is dispersed are mixed and emulsified, so that the water-soluble bitter drug is embedded into an inner phase of a water-in-water emulsion, and the traditional Chinese medicine taste-masking water-in-water Pickering emulsion is prepared. The traditional Chinese medicine taste-masked water-in-water Pickering emulsion is dried and granulated, and the traditional Chinese medicine taste-masked microcapsule can be obtained. The traditional Chinese medicine taste-masking water-in-water Pickering emulsion and microcapsule provided by the invention have excellent taste-masking effect and good stability, effectively solve the problem of poor taste-masking effect of traditional Chinese medicine preparations, provide a new method for taste masking of extremely bitter traditional Chinese medicines, and have important significance for development and application of traditional Chinese medicine taste-masking preparations.

According to the oseltamivir phosphate granules and the preparation method thereof, the granules are prepared by mixing the medicine-containing granules, the blank granules and the pharmaceutically acceptable auxiliary materials, and by selecting the specific auxiliary materials and the proportion of the auxiliary materials, the prepared granules maintain a high dissolution speed and achieve a good taste masking effect; according to the present invention, the traditional Chinese medicine composition has advantages of good taste, high content uniformity, high dissolution speed, good fluidity, low related substance content, good stability and the like, can meet different administration dosage requirements, and is suitable for children administration, and the pharmaceutical composition can be used for children, and can be used for preparing drugs for children, such that the pharmaceutical composition has characteristics of good taste, high content uniformity, high dissolution speed, good fluidity, low related substance content, and the like.

The present disclosure is directed to improved palatable chewable composition products that contain at least one encapsulated primary ingredient. Encapsulation prevents unpalatable flavors or unpleasant odors from the primary ingredients during ingestion. The disclosed palatable chewable compositions maintain palatability through manufacturing and shelf life.

The present disclosure relates to a method for preparing a veterinary medicament dosage using a 3D printer. The method comprises printing a plurality of layers comprising one or more active pharmaceutical ingredients (APIs) on the printing substrate, so that each layer comprising API is surrounded by layers comprising one or more taste masking agents, until a required dose of the one or more APIs is obtained. The disclosure also relates to a veterinary medicament dosage obtainable by the method.

The present invention relates to pantoprazole sodium preparations, and relates to a sublingual tablet containing pantoprazole sodium, at least one diluent, at least two flavoring agents, at least one taste masking agent, at least one binder, at least one disintegrant, at least one lubricant, and at least two buffer salts. The preparation contains 20 mg of pantoprazole sodium; the sublingual tablet of pantoprazole sodium in a specific ratio has a quality that meets the requirements of sublingual tablets and has a relatively fast disintegration and dissolution rate. Other advantages of the pharmaceutical preparation of the present invention are simple preparation process, stable product quality, rapid dissolution of the drug, and fast onset of action. The present invention also relates to a preparation method of the pantoprazole sodium sublingual tablet. The sample prepared by this method complies with the relevant regulations of sublingual tablets.

The present invention relates to a novel oral solution of a bitter drug using vitamin E TPGS as a masking agent. Atoxetine HCl is an example of a bitter drug, the bitter taste of which can be masked by the presence of vitamin E TPGS.

The invention discloses a leucine-containing dipeptide mixture easy to dissolve and reduced in bitterness as well as a preparation method and application of the leucine-containing dipeptide mixture. The mixture comprises the following components in percentage by mass: not less than 90% of alanyl-leucine, 0-5% of free leucine, less than 1% of water and not more than 0.10% of other impurities. The solubility of the mixture at room temperature reaches up to 500 g / L, the mixture is kept transparent and free of precipitates, the bitterness is reduced by 65% or above compared with leucine, the taste can be improved without a taste masking agent, and the mixture is suitable for sports nourishment and functional food. According to the preparation method, an enzyme catalysis reaction is adopted, and the steps of solid-liquid separation, pH adjustment, crystallization, nanofiltration concentration, drying and the like are performed, so that the total yield is not lower than 90%, the purity is not lower than 99.5%, and high solubility, low bitter taste, instant solubility and environmental friendliness are achieved; and the method has a wide industrial application scene.

This application discloses coated granules, solid dispersions, combinations and formulations for oral taste masking, which have been shown to improve the taste masking effect of vortioxetine hydrobromide and increase patient compliance and tolerability.

The present invention relates to an oral film containing ebastine and a preparation method thereof, belonging to the field of pharmaceutical technology. During the preparation of the mucilage, methylcellulose and polyacrylic resin are used as film-forming agents. When the mass ratio of the film-forming agent to purified water is controlled at 1:3 to 5, and the mass ratio of polyacrylic resin to methylcellulose in the film-forming agent is 0.5 to 2.5:1, the resulting mucilage is a viscous paste, the film has good flexibility and film-forming property, the film has no insoluble substances and good flexibility, has no bitter taste in terms of taste, has a cool and sweet taste, the active ingredient dissolves rapidly and fully, has good dissolution effect, stability, taste masking effect and compliance. Compared with the existing dosage forms on the market, it is more suitable for the elderly and children and has great clinical significance.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

The invention discloses granules of a composition containing polygala tenuifolia. The granules further comprise an excipient and an adhesive, wherein the weight ratio of the dry paste powder of the composition to the excipient to the adhesive is (0.5-1.5): (0.5-2.5): (0.01-1), the composition comprises polygala tenuifolia, rhizoma acori graminei and poria with hostwood, the excipient is microcrystalline cellulose, and the adhesive is povidone and / or maltodextrin. The granules improve the compliance of clinical medication of patients, especially elderly patients, and meanwhile, a solution is provided for taste masking of other preparations containing polygala tenuifolia medicine taste related components.

The invention discloses a pH sensitive berberine hydrochloride solid dispersion which comprises berberine hydrochloride, a pH sensitive polymer and a plasticizer, the mass ratio of the berberine hydrochloride to the pH sensitive polymer is 1: (1-9), and the pH sensitive polymer is dissolved in a solution with the pH larger than 5.5. The pH-sensitive polymer is used as a carrier material of berberine hydrochloride, the dissolution of berberine hydrochloride in gastric juice can be inhibited by forming a charge-assisted hydrogen bond between the pH-sensitive polymer and berberine hydrochloride, and the pH-sensitive polymer can be quickly dissolved in a solution with the pH being greater than 5.5, so that quick release in intestinal tracts can be realized; therefore, the absorption of the medicine in the intestinal tract is improved, and the bioavailability is further improved. Meanwhile, the flavoring agent is also added, the bitter taste is mixed through competition between the sour taste of the flavoring agent and a bitter taste receptor, the pH of oral saliva is adjusted, the dissolution of berberine hydrochloride in the oral cavity is further inhibited, and a good taste masking effect is achieved.

The present application relates to a kind of oseltamivir compositions and its preparation method, belong to the field of pharmaceutical preparation.The composition oseltamivir or its pharmaceutically acceptable salt, taste masking agent and optionally other pharmaceutically acceptable auxiliary materials.The taste masking agent is a kind of water-insoluble material or a kind of enteric material.The composition is convenient to take, good taste masking, good taste, fast release, good stability.The preparation method is good in reproducibility, and preparation is simple.

The invention provides an oral soluble film containing cariprazine or pharmaceutically acceptable salts thereof and a preparation method of the oral soluble film. The prepared oral soluble film has excellent effects of taste masking, stability, dissolution and the like, is convenient to take, can effectively improve the compliance of schizophrenia patients, and avoids behaviors of medicine hiding, medicine vomiting and the like.

The present application relates to a kind of high stability's bexontan solution, with 0.1-10% bexontan, 20-50% high molecular material and buffer solution in bexontan solution with mass volume percentage, wherein, the high molecular material is selected from any one or combination of polymethyl methacrylate, cyclodextrin, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, the buffer solution is selected from any one of citric acid buffer solution, phosphate buffer solution, malic acid buffer solution, succinic acid buffer solution, tartaric acid buffer solution, lactic acid buffer solution, acetic acid buffer solution, bexontan solution pH4-7.5.The bexontan solution of the present application significantly delays the diffusion of drug bitter taste in oral cavity and realizes taste masking, and has excellent stability, more optimal cost, quality controllable, good taste and the like advantages.

According to the salbutamol sulfate-containing oral solution and the preparation method thereof provided by the invention, sucralose or acesulfame potassium is taken as a flavoring agent, so that the oral solution is relatively good in dissolvability, can relieve bitter taste and obtain a relatively good taste masking effect, is relatively good in taste, improves the medication compliance of a patient, improves the stability of the oral solution and prolongs the validity period of the medicine. The oral solution containing salbutamol sulfate provided by the invention is simple in preparation method, and has good taste masking effect and stability.

The invention relates to taste-masking vinegar powder as well as a preparation method and application thereof. The composition comprises highly branched cyclodextrin and fermented vinegar liquid, the weight part ratio of the fermented vinegar liquid to the highly branched cyclodextrin is 1: (2-4); the highly branched cyclodextrin has a long-chain structure with a spiral structure; the molecular weight of the highly branched cyclodextrin is 90-130KD, and the DE value of the highly branched cyclodextrin is 0.5-8. The technical problem to be solved is how to provide the taste-masking vinegar powder which not only has an anti-corrosion effect, but also can effectively mask and improve the pungent smell of vinegar.

The application belongs to the technical field of medicine, and particularly relates to a andrographolide anhydrous swallowing granule and a preparation method thereof. The andrographolide anhydrous swallowing granule is formed by mixing drug-containing microcapsules and flavoring auxiliaries. The drug-containing microcapsules are prepared by centrifugal hot melt spraying technology from andrographolide and high-melting-point capsule materials. The high-melting-point capsule materials are one or more of Brazil palm wax, hydrogenated castor oil, microcrystalline wax, rice bran wax and sugarcane wax. The flavoring auxiliaries are fillers, sweeteners, essences and pH regulators. The prepared granule has the characteristics of small particle size, smooth surface, good fluidity, no grit feeling, no sticky teeth feeling and easy swallowing. Moreover, the granule has a significant taste masking effect, no bitterness, moderate sweetness and moderate fragrance, which helps to improve patient compliance, and is particularly suitable for old people and children patients who have difficulty in swallowing. The centrifugal hot melt spraying technology adopted by the application is simple in process, low in cost, green and pollution-free, and suitable for large-scale production.

The invention provides a Huoxiang Zhengqi direct-taking taste-masking composition and a preparation method, and belongs to the technical field of pharmaceutical preparations, the Huoxiang Zhengqi direct-taking particle composition comprises the following components by weight: 60-100 parts of a traditional Chinese medicine composition, 1-5 parts of a taste regulator, 1-10 parts of an anti-sticking agent, 1-5 parts of a plasticizer, and 10-50 parts of a polymer coating material; the traditional Chinese medicine composition comprises the following raw materials: pogostemon cablin, folia perillae acutae, radix angelicae, pericarpium arecae, poria cocos, rhizoma atractylodis macrocephalae, pericarpium citri reticulatae, mangnolia officinalis, raw pinellia ternate, platycodon grandiflorum and liquorice. The prepared Huoxiang Zhengqi direct-taking taste-masking composition is remarkable in taste-masking effect, the compliance is improved, the bad taste is completely masked through the powder coating technology, the taste-masking composition is combined with other flavoring agents, the cool and sweet taste can be provided, and the medication compliance of a patient is remarkably improved.

The present disclosure relates to a taste-masking microcapsule composition. The composition comprises a core portion encapsulated by a shell portion. The core portion comprises an active pharmaceutical ingredient (API) and one or more excipients. The shell portion comprises a hydrophobic matrix and a pH-responsive material. The microcapsule compositions prevent API release at the more neutral pH levels in the oral cavity, but upon exposure to pH levels of the stomach, the pH-responsive material becomes soluble thereby permitting release of the API.

The application belongs to the technical field of traditional Chinese medicine preparation, and discloses a traditional Chinese medicine pellet preparation based on intestinal flora regulation and a taste masking process thereof. The traditional Chinese medicine pellet preparation is realized intestinal positioning release through specific sequence process, isolation layer and enteric coating in cooperation with taste masking. After the pellet is released in the intestinal positioning release, the contained medicinal material components can regulate intestinal flora in cooperation, and the intestinal flora can also transform the medicinal material components so that the medicinal material components are more easily absorbed. The effect of the pellet preparation of the application on regulating intestinal flora is better than that of ordinary preparation, which indicates that intestinal positioning release promotes drug efficacy. The application realizes complete taste masking, enhanced drug efficacy and high patient compliance through double cooperation.

The invention discloses a salbutamol sulfate oral solution and a preparation method thereof.According to the salbutamol sulfate oral solution, a physical barrier is formed through inclusion of hydroxypropyl-beta-cyclodextrin, and a stability synergistic mechanism is formed through the chelating chemical inhibition effect of EDTA-2Na, so that the oxidative degradation rate of salbutamol sulfate is obviously reduced; in addition, sucralose and peppermint essence are used as flavoring agents for taste, high-sweetness taste modification and cool taste modification are performed, and triple taste masking of HP-beta-CD inclusion, sucralose and peppermint essence is performed, so that the taste score is remarkably improved; by destroying intestinal epithelium tight connection through sodium cholate, the transmembrane transport efficiency is improved, the bioavailability is improved, the apparent permeability coefficient (Papp) is remarkably improved, the problem of low availability caused by the first-pass effect is solved, beagle is orally taken, the bioavailability is remarkably improved, and the application prospect is remarkable.

A coated granule, a solid dispersion, a composition, and a preparation for oral masking, which improve the taste masking effect of vortioxetine hydrobromide, and improve the patient adherence and compliance.

This application provides a novel formulation of pridopidine drug in the form of particles designed to mask the intensely bitter taste of pridopidine while enabling rapid drug release. The formulation provides improved taste masking and dissolution characteristics, making it suitable for oral administration. The invention further relates to the process for preparation of the particles, methods of their administration, and to methods of using the formulation in the treatment of neurodegenerative or neurodevelopmental disease or disorder.

The invention discloses compound alpha-keto acid granules without peculiar smell as well as a preparation method and application thereof, and relates to the technical field of medicines. The compound alpha-keto acid granules comprise taste masking granules 1, taste masking granules 2 and taste modifying components, the taste-masking particles 1 comprise amino acid, an adhesive 1 and a taste-masking material 1, and the mass ratio of the amino acid to the adhesive 1 to the taste-masking material 1 is 249: (13-35): (15-30); the taste-masking particles 2 comprise ketonic acid calcium, an adhesive 2 and a taste-masking material 2, and the mass ratio of the ketonic acid calcium to the adhesive 2 to the taste-masking material 2 is 381: (20-42): (40-75). Compared with tablets, the granules prepared by the preparation method disclosed by the invention are better in smell and taste, and higher in stability under high-temperature, high-humidity and strong-light irradiation.

This invention belongs to the fields of computational pharmacy and pharmaceutical preparation technology, specifically relating to a method for preparing taste-masking capsules based on molecular simulation and its application. Specifically, this invention employs molecular simulation to prepare taste-masking capsules, focusing on screening highly effective taste-masking agents that match the target bitter-tasting drug. Molecular simulation can reveal the interaction between bitter-tasting drugs and taste-masking agents from a microscopic molecular perspective, exploring the dispersion of bitter-tasting drugs on the surface of the taste-masking agent. It can simulate multiple matching scenarios in a short time, allowing for the selection of the most effective taste-masking scheme from numerous combinations of bitter-tasting drugs and taste-masking agents. Experiments have demonstrated that this invention can prepare taste-masking capsules for bitter-tasting drugs as needed, thereby improving medication compliance and meeting the needs of bitter-tasting drug use, thus possessing significant practical application value.

This application belongs to the technical field of traditional Chinese medicine pastes, specifically relating to a preparation process for traditional Chinese medicine pastes that improves anti-sanding, taste masking, and flowability. This process utilizes lemon juice to catalyze the hydrolysis of sucrose, stably controlling the sucrose conversion rate at over 95%, thus eliminating the risk of sanding at the source. Furthermore, it combines the physical barrier mechanisms of β-cyclodextrin and microcrystalline cellulose to form a triple anti-sanding barrier of chemical conversion, physical inclusion, and steric hindrance. Simultaneously, the efficient inclusion of β-cyclodextrin in Coptis chinensis alkaloids effectively masks the taste; and the "microsphere bearing" effect of microcrystalline cellulose solves the problem of sticking to the sides and spoon.

The liquid vehicles can be used to create dilute solutions of water-soluble pharmaceutical or non-pharmaceutical oral contrast agents. The liquid vehicles are formulated to provide desired osmolalities, viscosities, pH, and taste masking capabilities to match the particular intentions of the user and to complement the inherent differences in the various oral contrast agents. The liquid vehicles comprise an aqueous medium, an osmotic agent to adjust osmolality, a buffering agent, a viscosity agent, and sweeteners and flavoring agents to improve palatability.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

The invention involves novel, oral solutions of bitter drugs using Vitamin E TPGS as a masking agent and methods of using the same (e.g., for treating attention deficit / hyperactivity disorder (ADHD)). Atomoxetine (e.g., Atomoxetine HCl) is an example of a bitter drug whose bitterness can be masked by the presence of Vitamin E TPGS alone or in combination with additional ingredients.