8 results about "Taste masking" patented technology

The present disclosure is directed to improved palatable chewable composition products that contain at least one encapsulated primary ingredient. Encapsulation prevents unpalatable flavors or unpleasant odors from the primary ingredients during ingestion. The disclosed palatable chewable compositions maintain palatability through manufacturing and shelf life.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

A coated granule, a solid dispersion, a composition, and a preparation for oral masking, which improve the taste masking effect of vortioxetine hydrobromide, and improve the patient adherence and compliance.

This application belongs to the technical field of traditional Chinese medicine pastes, specifically relating to a preparation process for traditional Chinese medicine pastes that improves anti-sanding, taste masking, and flowability. This process utilizes lemon juice to catalyze the hydrolysis of sucrose, stably controlling the sucrose conversion rate at over 95%, thus eliminating the risk of sanding at the source. Furthermore, it combines the physical barrier mechanisms of β-cyclodextrin and microcrystalline cellulose to form a triple anti-sanding barrier of chemical conversion, physical inclusion, and steric hindrance. Simultaneously, the efficient inclusion of β-cyclodextrin in Coptis chinensis alkaloids effectively masks the taste; and the "microsphere bearing" effect of microcrystalline cellulose solves the problem of sticking to the sides and spoon.

The application discloses a kind of intestinal flora transplantation freeze-dried powder biological agent and preparation method thereof, freeze-dried powder biological agent includes the mixed powder prepared mainly with inulin, sweet orange fruit powder, cydonia freeze-dried powder, day day flower freeze-dried powder and intestinal bacteria freeze-dried powder;Mixed powder is according to mass fraction, ratio is as follows:inulin 75 parts, sweet orange fruit powder 10 parts, cydonia freeze-dried powder 12 parts, day day flower freeze-dried powder 3 parts;Intestinal bacteria freeze-dried powder and mixed powder are according to mass ratio 7:3;In the application, construct the four-element composite protection system of inulin+sweet orange fruit powder+cydonia freeze-dried powder+day day flower freeze-dried powder, realize "active protection+flavor blending+medicinal auxiliary+synergistic taste masking" fourfold efficacy through accurate component allocation ratio design;The selection of sweet orange fruit powder is in line with the dispersibility requirement of freeze-dried powder, the rich aroma of cydonia freeze-dried powder is synergized with day day flower freeze-dried powder, accurately covers up the fishy smell of freeze-dried powder, and formula ratio adapts to the mixing process of freeze-dried powder, ensure that there is no particle aggregation, improve preparation uniformity.

This invention relates to the field of pharmaceutical preparations, specifically providing anhydrous rimantadine hydrochloride granules and a method for preparing the same. The anhydrous rimantadine hydrochloride granules are a mixture of drug-containing taste-masked granules and flavor-correcting granules. The drug-containing taste-masked granules comprise rimantadine hydrochloride and a taste-masking material, wherein the taste-masking material is a lipid or waxy material. This invention, by selecting a lipid or waxy material as the taste-masking material and mixing it with rimantadine hydrochloride to prepare drug-containing taste-masked granules, and then mixing them with flavor-correcting granules, effectively masks the taste and allows for direct swallowing without water, greatly improving medication adherence, especially suitable for children, the elderly, and other individuals with swallowing difficulties. Furthermore, the preparation method of this invention is simple, requires minimal equipment, is low-cost, and suitable for large-scale production.

This invention discloses a compound taste-masking composition for leech decoction, the taste-masking leech decoction, its preparation method, and its application, belonging to the field of traditional Chinese medicine pharmaceutical technology. This invention provides a compound taste-masking composition composed of adenosine monophosphate (AMP), hydroxypropyl-β-cyclodextrin (HP-β-CD), and steviol glycosides, and provides its application method: first, HP-β-CD is added for inclusion and deodorization, then AMP and steviol glycosides are added to synergistically suppress bitterness. This combination utilizes a complementary strategy of "physical inclusion-receptor antagonism-taste neutralization" to simultaneously and efficiently mask the bitterness and fishy taste of leech decoction. Through orthogonal experimental optimization and verification using electronic tongue and sensory evaluation, the optimal formula (AMP 0.10%, HP-β-CD 0.50%, steviol glycosides 0.03%) reduces the bitterness score from 9.3 to 0.6 and the fishy taste score from 9.6 to 1.0. The method of this invention is performed at room temperature and pressure, is simple in process, does not affect the main active ingredients, is suitable for industrial production, and can significantly improve patients' compliance with leech decoction.

The application provides a lumerongan tosylate orally disintegrating tablet and a preparation method thereof. The orally disintegrating tablet comprises lumerongan tosylate core granules, a taste masking layer and an additional excipient layer, and an optional isolation layer. The lumerongan tosylate orally disintegrating tablet of the application not only has effective taste masking, good formability, rapid disintegration in the oral cavity, excellent disintegration and release effects, but also has good stability and safety, and ensures the product quality of the drug in the process of packaging, transportation and carrying.