The invention provides an ambroxol hydrochloride taste-masking granule, which is prepared from drug-loaded pellets coated by a taste-masking layer and a taste modifying material. Specifically, the drug-loaded pellets coated by a taste-masking layer consist of three layers from the inside out: a drug-loaded pellet core, an isolation layer and a taste-masking layer. The drug-loaded pellets provided by the invention are prepared by a fluidized bed suspension drug-feeding way, the drug-loaded pellet core is externally coated with the isolation layer and the taste-masking layer in order, each layer is coated with a fluidized bed, the taste modifying material is prepared by wet granulation, and the pellets and the taste modifying material are mixed to prepare the granule. The ambroxol hydrochloride taste-masking granule provided by the invention completely covers up the peculiar smell of drug itself, improves the compliance of medication for children, and is added with a sweetener and sugar-containing granules suitable for children to take so as to remove the bitter taste and peculiar smell of chemical drugs, in addition to sugar, the ambroxol hydrochloride taste-masking granule is also added with some fruit essence to greatly improve the mouthfeel of drug, so that children patients can easily accept or actively require to accept the drug, thus enhancing compliance of medication for children. By controlling the particle size of the bulk drugs, the drug feeding yield is increased, the content of drug-loaded pellets is improved, and the particle number of pellets in unit preparation can be reduced, thus reducing the weight increment range of the taste-masking layer, and reaching the purposes of saving labor-hour and cost, and increasing yield.