122 results about "Tissue distribution" patented technology

Highly efficient cationic liposomes have been developed as an improved delivery system for biologically-active reagents. A novel structure, the sandwich liposome, is formed and comprises one or more biologically active agents internalized between two bilomellar liposomes. This structure protects the incoming agent and accounts for the high efficiency of in vivo delivery and for the broad tissue distribution of the sandwich liposome complexes. These novel liposomes are also highly efficient carriers of nucleic acids. By using extruded DOTAP:cholesterol liposomes to form complexes with DNA encoding specific proteins, expression has been improved dramatically. Highest expression was achieved in the lung, while increased expression was detected in several organs and tissues.

The invention provides a method for preparing an ultra-high hardness cladding layer through the synchronous ultrasonic vibration assisting laser technology. According to the specific scheme, the method includes the steps that ultrasonic vibration is synchronously introduced in the Ni-based metal ceramic coating cladding process, mobility of liquid metal can be improved in the mode, tissue distribution is more uniform, in the solidification process, a growing dendrite net can be broken and made to be dispersed to all portions of melt, small crystal nucleuses which are uniformly distributed are formed, segregation of metal ceramic is avoided, and therefore it is guaranteed that the cladding layer is not prone to cracking when ultra-high hardness is acquired; equipment is simple, calibration and installation are facilitated, energy consumption is low, the working environment is good, and acquired coating metal ceramic particles are uniform in distribution, high in hardness and good in abrasion resistance.

The invention relates to a diamond/copper composite material with high heat-conducting property and a preparation method thereof and belongs to the field of metallic materials. The diamond/copper composite material is composed of copper or copper alloy, diamond particles and a transition layer, wherein volume fraction of the copper or copper alloy is 38-49%, the volume fraction of the diamond particles and the transition layer is 62-51%, and particle size range of diamond is 80-130Mu m. A preparation technological process comprises the following steps: carrying out pre-treatment on the diamond, plating by adopting a salt bath, preparing a performed blank, and preparing a composite material by carrying out non-pressure infiltration. The diamond/copper composite material has the advantages that a diamond/copper composite material with high volume fraction and high heat-conducting property can be directly moulded and prepared, the prepared composite material is high in density, uniform in tissue distribution, controllable in interface thickness and high in thermal conductivity, processing equipment is simple, operability is strong, energy consumption and cost are low, mass production can be realized, heat-conducting property is high, and the diamond/copper composite material can be applied to the field of thermal management or electronic packaging.

A method and apparatus configured to analyze breast density based on magnetic resonance imaging (MRI) of a breast of a patient includes the steps of segmenting an MR image of the breast from one set of three-dimensional breast MRI images, and analyzing the amount of dense tissue and the morphological distribution of the dense tissue and a data processor configured by software to perform these steps. Analyzing the amount of dense tissue and the morphological distribution of the dense tissue includes the steps of segmenting tissue data to separate breast tissue from other body tissue, separating tissue data of the dense and fatty tissues in the breast, and analyzing the morphological distribution of dense tissue in the breast to derive one or more three dimensional morphological parameters of the dense tissue distribution.

The invention relates to a preparation method of diamond particle reinforced copper-based composite material parts with high volume fraction, belonging to the field of metal materials. The preparation method is characterized in that the composite material comprises copper or copper alloy, diamond particles and an intermediate layer, wherein the volume fraction of the copper or the copper alloy is 32-45 percent, and the volume fraction of the diamond particles and the intermediate layer is 55-68 percent. The preparation method comprises the following steps of: firstly forming a TiC-Ti composite thin plating layer on the surface of the diamond by adopting a vacuum salt bath plating method, then adding an appropriate amount of caking agent into modified diamond powder and pressing into a porous prefabricated blank according to the shape of the parts; and finally putting the porous prefabricated blank and the copper or the copper alloy into a vacuum condition together for carrying out pressureless infiltration treatment to obtain the diamond-copper composite material parts with high volume fraction and high density. The invention has the advantages that the diamond-copper composite material parts with high volume fraction and the complex shape can be directly prepared, and the composite material parts have high density, even tissue distribution and low production cost, and can realize large-batch production.

The invention discloses a device for determining a border of a target region of a medical image, which is used for differentiating the border of the target region according to corresponding physical quantitative properties reflected by tissue distribution in the medical image. The device comprises: an interactive unit, by which an operator can select the target region on the medical image; a threshold setting unit, which determines threshold values of the physical quantitative properties in the target region selected; and a thresholding segmentation unit, which divides the region to be analyzed or the region of interest into sub-regions, or fills image cells (pixels) in the region to be analyzed, wherein the region to be analyzed contains the target region, and the sub-regions are the sub-regions which are segmented in the image. The thresholding segmentation unit compares average parameter values of the physical quantitative properties of each sub-region with the threshold values and marks all the cells according to comparison results. The present invention provides a calculating and processing method and a device with clear physical significance and a simple and effective algorithm, and the method and the device are particularly suitable for processing special situations of various hearts with pathological changes in clinical art.

The invention relates to a steel pipe continuous quenching process control method based on numerical simulation. The method comprises the following steps that initial technological parameters of the continuous induction quenching process are calculated according to the moving linear speed and quenching cooling water spraying pressure of a steel pipe, and the initial technological parameters comprise a heating process technological parameter and a quenching process technological parameter; finite element analysis is carried out on the steel pipe continuous induction heating process, and the relation between the heating process technological parameter and the internal and external surface temperature of the steel pipe is obtained; finite element analysis is carried out on the steel pipe quenching cooling process, and the relation between the quenching process technological parameter and the steel pipe tissue distribution condition is obtained; according to the process control requirement, the heating process technological parameter and the quenching process technological parameter conforming to the technological control requirement are obtained, and a final steel pipe continuous induction quenching process control parameter is formed; the obtained control parameter is used for controlling the actual steel pipe continuous quenching process. Compared with the prior art, the method has the advantages of reducing energy consumption caused by technological parameter determining through preproduction, improving the working efficiency and the like.

The invention belongs to the technical field of medicines, and relates to honokiol nanoparticles and a preparation method thereof. The honokiol nanoparticles are prepared by adopting an ultrasonic-precipitation method in combination with a freeze-drying technology, and the composition of prescription is as follows: the combination ratio of honokiol to a stabilizer is 1:(0.05-50). According to the honokiol nanoparticles and the preparation method thereof, through prescription optimization, povidone (PVP) and bovine serum albumin (BSA) are screened as the best stabilizer combination. The prepared honokiol nanoparticles are high in drug loading, stable in nature, simple in prescription composition, easy, convenient and feasible in preparation process, and the particle size range is 100nm-300nm; and through the preparation of the nanoparticles, the dissolution of honokiol can be obviously promoted, the oral bioavailability is improved, and tissue distribution in the body is improved. In addition, the honokiol nanoparticles can be freeze-dried, and a suitable excipient is added into the obtained freeze-dried powder for further preparing different dosage forms such as oral liquid, tablets, granules and capsules, and also can be prepared into injection for subcutaneous, muscle or intravenous drug delivery so as to be convenient for clinical application.

The invention discloses a preparation method of a silicon nitride-titanium carbonitride micro-nano composite material. The preparation method comprises steps as follows: nano silicon nitride, nano titanium carbide and submicron titanium carbonitride powder are added to a submicron-grade silicon nitride matrix, MgO and Y2O3 are added and serve as sintering aid, and the composite material with relatively high obdurability and hardness is prepared through a reasonable sintering process, wherein the length-diameter ratios of silicon nitride crystal particles are distributed in a bimodal manner, and the sizes of the crystal particles are normally distributed. The material is uniform in tissue distribution, and the bending strength, the breaking tenacity, the hardness and the thermal shock resistance are improved obviously.

The invention describes a method that provides a practical means of accurately estimating the electromagnetic fields and therefore the SAR (specific absorption rate) distributions of a subject in magnetic resonance imaging (MRI) scan. The disclosed method consists of several steps. If the coil information is unavailable during the patent imaging, the first step, generally performed before patient (or target) imaging, estimates the geometry of the radiofrequency (RF) coils. The second step estimates the patient-specific tissue volumes by deforming an appropriate reference with known tissue distribution from a database to the said target. Finally, the electromagnetic fields and the SAR distributions are calculated using numerical methods performed on the accurately estimated RF coils and patient-specific tissue volumes. The proposed method can be used for safe, accurate MR imaging at any magnetic field strengths, particular suitable for high-field applications.

The invention discloses steel for a saw web and a hot rolled steel plate production method thereof. The steel for the saw web comprises the chemical compositions of, by mass, 0.73-0.77% of C, 0.16-0.26% of Si, 0.80-1.20% of Mn, no larger than 0.03% of P, no larger than 0.03% of S, 0.005-0.020% of Als, 0.0008-0.0022% of Ca, 0.35-0.49% of Cr, 0.11-0.20% of V, and the balance Fe and unavoidable impurities; and the production method comprises the following processes of smelting, continuous casting, heating, rolling and straightening. The plasticity and toughness of steel plates manufactured by thehot rolled steel plate production method are improved, the tissue distribution is even, the shape, dimensional precision and surface quality are improved, and wear-resisting property and fatigue strength are good, and the steel plates are suitable for manufacturing thicker saw webs.

The invention discloses a high-heat-conduction near-net-shaped diamond/copper composite and a preparing method thereof, and belongs to the field of metal materials. The diamond/copper composite is of a three-dimensional communication structure and is composed of a diamond particle framework, a transition layer, metal copper and surface seepage copper; the preparing method comprises the steps that diamond particles subject to salt-bath plating W are subject to near net shaping, and a pressure-free infiltration method is adopted to prepare the high-heat-conduction composite. The method effectively solves the problems about compatibility of diamond and metal, difficult machining of the diamond/copper composite, poor surface quality, single product shapes, high production cost and the like; the prepared composite is high in compactness, uniform in structure distribution, controllable in interface thickness, high in heat conduction rate, simple in process device, high in operation, low in energy consumption cost, capable of being produced in a large-batch manner, and capable of meeting the requirement of the heat management or electronic package field and has the high heat conduction property.

The invention discloses an alprostadil lipid nanosphere freeze-drying injection and a preparation method thereof, and belongs to the technical field of medicines. The alprostadil lipid nanosphere freeze-drying injection is prepared from the following raw materials in part by weight: 0.0005 to 0.1 part of alprostadil, 15 to 60 parts of medium-chain oil, 3.0 to 35 parts of emulsifier, 8.5 to 48 parts of polyethylene glycol-12-hydroxy stearate, 22 parts of glycerol, 20 to 200 parts of trehalose, and 20 to 300 parts of cyclodextrin. The particle size of the alprostadil lipid nanosphere freeze-drying injection after redissolution is less than 100nm; and an aseptic filtration way can be used for sterilization, so that the disadvantage of thermal instability of the alprostadil is overcome, and the stability of products is improved. Meanwhile, lipid nanospheres have smaller particle sizes which are less than 100nm, so the alprostadil lipid nanosphere freeze-drying injection is more favorable for the distribution of the alprostadil in in-vivo non-reticuloendothelial system (RES) tissues, reduces pulmonary circulation inactivation and blood clearance, is favorable for circulating in vivo for a long time, and is suitable for the treatment of cardiac and neurosurgical diseases.

The invention provides a deep conical copper shaped charge liner tissue ultrafine crystallization gradient control method, which comprises the steps of extrusion shaping, re-crystallization heat treatment and high-frequency percussion, wherein in the extrusion shaping step, multi-pass extrusion is used; the high-frequency impact knocking speed is 15000 to 40000 times/minute; the knocking force is1200 to 2000 N; the times is 1 to 3 times. The control technology provided by the invention realizes the deep conical copper shaped charge liner shaping and surface quality control; the material plasticity is improved; the fine crystal tissues can be obtained; the ultrafine crystal gradient tissues distributed in the thickness direction are formed on the surface layer in the charge shaped liner. The ultrafine crystal gradient tissues distributed in the thickness direction of the charge shaped liner are obtained by using the method; the tissue distribution in the bus direction is uniform; a novel preparation method is provided for the invention of the high-performance deep conical copper shaped charge liner.

The invention relates to an antineoplastic nanometer heat sensitive target medicinal carrier used combined with chemical therapy and heat therapy, wherein the nano heat-sensitive targeting medicinal carrier employs amphiphilic segmented copolymer micelle, the hydrophobic fragments form inner cores, the hydrophilic fragments form outer-shells, the outer-shells surround the inner cores. the hydrophilic fragments comprise heat-sensitive polymers with a low critical solution temperature at 37-42 deg. C, the hydrophobic fragments comprise polylactic acid. The invention can avoid the injury to normal human tissue cells by chemotherapy medicaments.

The invention discloses a connection method for thick plate TiNi alloy and titanium alloy dissimilar materials. The connection method comprises the following steps that a TiNi alloy is subjected to acid pickling to the specified thickness; abrasive paper is used for grinding welded end faces of the dissimilar materials till the welded end faces are level; the position between the butt-joint materials is filled with Nb bars, and a clamp is used for fixing the welding materials; and finally the clamp and the welding materials are fed into an electronic beam equipment vacuum chamber together, electronic beams deviate to one side of a titanium alloy for welding, and a welding joint high in strength and good in comprehensive mechanical performance is obtained. According to the welding method, cracks generated by thick plate TiNi alloy and titanium alloy welding are eliminated; forming of Ti2Ni and other brittle intermetallic compounds is hindered; structure distribution is uniform, and grains are finer; and the strength of extension of the scanning welding joint reaches 551 MPa, the joint toughness is good, good comprehensive performance is achieved, and large engineering significance is achieved.

The invention discloses a single-sided internal oxidation silver tin oxide indium oxide electric contact material which comprises a silver tin oxide indium oxide material body. One side of the silvertin oxide indium oxide material body is a solder surface with a solder. The solder surface is composed of an AgSn layer or an AgZn layer. The other side of the silver tin oxide indium oxide material body is an oxidation surface. The oxidation surface is an AgSnO2In2O3 layer. The invention further provides a preparation method of the material. According to the acquired single-sided internal oxidation silver tin oxide indium oxide electric contact material, subsequent welding is convenient and reliable; the acquired silver tin oxide indium oxide is single-sided oxidation, which prevents an intermediate 'lean oxide' area; and tissue distribution is even.

The invention discloses a preparation method of a graphite-ball-enhanced aluminium-based composite material with high heat-conductivity isotropy, and belongs to the field of metal materials. The aluminium-based composite material contains the following components according to volume fraction: 40%-80% of pure-aluminium powder and 20%-60% of graphite ball. The production process comprises the following steps: firstly mixing the pure-aluminium powder and the graphite ball powder according to corresponding volume-fraction proportion, then placing the mixed powder into a graphite mold together to carry out spark plasma sintering, and thus obtaining the graphite-ball-aluminium-based composite material with high volume fraction, high heat conductivity, high density and approximate isotropy. The preparation method disclosed by the invention has the beneficial effects that the prepared graphite-ball-aluminium-based composite material with high heat conductivity and approximate isotropy is highin density and uniform in tissue distribution, and can realize large-batch production, low production cost and high practical level. The heat conductivity of the aluminium-based composite material isapproximately isotropic, and can reach 227.61W.m<-1>.k<-1> in the X and Y directions and 187.27W.<-1>.k<-1> in the Z direction. The heat expansion coefficient fluctuates between 6.4-10.6*10-6K<-1> under the room-temperature condition and the density can reach more than 98%.

The invention belongs to the technical field of medicines, and in particular relates to a nanosuspension of annonaceous acetogenin drugs prepared from such amphiphilic stabilizers as mPEG PCL, mPEG PLA, mPEG PLGA, mPEG DSPE, mPEG Chol, SPC, Tween80, BSA, TPGS and the like, as well as a preparation method and an application of the nanosuspension. The annonaceous acetogenin total lactone nanosuspension is prepared by virtue of a solvent precipitation-ultrasonic injection method, and according to a prescription, the proportioning ratio of the annonaceous acetogenin drugs to the stabilizer is at 1 to (0.02-10) (in percentage by weight). The prepared annonaceous acetogenin nanosuspension can reach a load-loading capacity to 90% to the greatest extent and can reach a minimum grain size to 123.2nm, and the nanosuspension is good in polydispersity. The nanosuspension is stable in both gastrointestinal fluid and plasma, and the nanosuspension is applicable to oral administration and injection administration; the nanosuspension has a good in-vitro sustained-release effect and is free from burst release; the nanoparticle, in comparison with a crude drug solution, is more obvious in tumor cell inhibitory rate in vitro; the nanosuspension, in in-vivo tissue distribution, shows tumor passive targeting; therefore, the nanosuspension is beneficial for enhancing efficacy and reducing toxic and side effects. Meanwhile, an in-vivo efficacy experiment shows that the nanosuspension is outstanding in antineoplastic efficacy, and the nanosuspension has a broad development prospect.