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122 results about "Tissue distribution" patented technology
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Tissue Distribution. Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding.
Novel liposome complexes for increased systemic delivery
Highly efficient cationic liposomes have been developed as an improved delivery system for biologically-active reagents. A novel structure, the sandwich liposome, is formed and comprises one or more biologically active agents internalized between two bilomellar liposomes. This structure protects the incoming agent and accounts for the high efficiency of in vivo delivery and for the broad tissue distribution of the sandwich liposome complexes. These novel liposomes are also highly efficient carriers of nucleic acids. By using extruded DOTAP:cholesterol liposomes to form complexes with DNA encoding specific proteins, expression has been improved dramatically. Highest expression was achieved in the lung, while increased expression was detected in several organs and tissues.
Owner:US DEPT OF HEALTH & HUMAN SERVICES
Biologically related substances modified by multifunctional H-type polyethylene glycol derivative
ActiveCN104530413ALow immunogenicityImprove distributionPharmaceutical non-active ingredientsFluorescencePolyethylene glycol
The invention discloses biologically related substances modified by a multifunctional H-type polyethylene glycol derivative. The derivative comprises a linear main axis LPEG and four PEG branched chains, and n1, n2, n3 and n4 are polymerization degrees of the branched chains, respectively; U1 and U2 are trivalent branching groups connecting the main axis LPEG with two PEG branched chains; F1 and F2 contain functional groups or their protected forms R01, and the number of R01 is one or more than one. Any linking group in the molecule or linking groups formed with adjacent heteroatom groups are stable or degradable; any PEG chain segment in the molecule independently shows polydispersity or monodispersity. One H-type molecule can modify multiple types of or multiple biologically related substances; the modified product has a flexible branching structure, a high drug loading capacity, optimized pharmacokinetics and tissue distribution, and can also carry two biologically related substances with different functions, so as to generate fluorescence property or targeting function.
Owner:XIAMEN SINOPEG BIOTECH
Method for preparing ultra-high hardness cladding layer through synchronous ultrasonic vibration assisting laser technology
InactiveCN104451673AIncreased microhardnessImprove wear resistanceMetallic material coating processesCeramic coatingLiquid metal
The invention provides a method for preparing an ultra-high hardness cladding layer through the synchronous ultrasonic vibration assisting laser technology. According to the specific scheme, the method includes the steps that ultrasonic vibration is synchronously introduced in the Ni-based metal ceramic coating cladding process, mobility of liquid metal can be improved in the mode, tissue distribution is more uniform, in the solidification process, a growing dendrite net can be broken and made to be dispersed to all portions of melt, small crystal nucleuses which are uniformly distributed are formed, segregation of metal ceramic is avoided, and therefore it is guaranteed that the cladding layer is not prone to cracking when ultra-high hardness is acquired; equipment is simple, calibration and installation are facilitated, energy consumption is low, the working environment is good, and acquired coating metal ceramic particles are uniform in distribution, high in hardness and good in abrasion resistance.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Methods of increasing efficiency of vector penetration of target tissue
InactiveUS9546112B2Improve efficiencyReduce the binding forceOrganic active ingredientsElectrotherapyGalectin 3 binding proteinAdeno associate virus
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.
Owner:UNIV PIERRE & MARIE CURIE +4
Diamond/copper composite material with high heat-conducting property and preparation method thereof
The invention relates to a diamond / copper composite material with high heat-conducting property and a preparation method thereof and belongs to the field of metallic materials. The diamond / copper composite material is composed of copper or copper alloy, diamond particles and a transition layer, wherein volume fraction of the copper or copper alloy is 38-49%, the volume fraction of the diamond particles and the transition layer is 62-51%, and particle size range of diamond is 80-130Mu m. A preparation technological process comprises the following steps: carrying out pre-treatment on the diamond, plating by adopting a salt bath, preparing a performed blank, and preparing a composite material by carrying out non-pressure infiltration. The diamond / copper composite material has the advantages that a diamond / copper composite material with high volume fraction and high heat-conducting property can be directly moulded and prepared, the prepared composite material is high in density, uniform in tissue distribution, controllable in interface thickness and high in thermal conductivity, processing equipment is simple, operability is strong, energy consumption and cost are low, mass production can be realized, heat-conducting property is high, and the diamond / copper composite material can be applied to the field of thermal management or electronic packaging.
Owner:NANCHANG HANGKONG UNIVERSITY
Method and Apparatus for Quantitative Analysis of Breast Density Morphology Based on MRI
ActiveUS20110150313A1Convenient investigationImage enhancementImage analysisBreast densityBreast MRI
A method and apparatus configured to analyze breast density based on magnetic resonance imaging (MRI) of a breast of a patient includes the steps of segmenting an MR image of the breast from one set of three-dimensional breast MRI images, and analyzing the amount of dense tissue and the morphological distribution of the dense tissue and a data processor configured by software to perform these steps. Analyzing the amount of dense tissue and the morphological distribution of the dense tissue includes the steps of segmenting tissue data to separate breast tissue from other body tissue, separating tissue data of the dense and fatty tissues in the breast, and analyzing the morphological distribution of dense tissue in the breast to derive one or more three dimensional morphological parameters of the dense tissue distribution.
Owner:RGT UNIV OF CALIFORNIA
Preparation method of diamond particle reinforced copper-based composite material parts with high volume fraction
InactiveCN101768706AImprove wettabilityImprove the interface binding forceLayered productsHigh densityHigh volume manufacturing
The invention relates to a preparation method of diamond particle reinforced copper-based composite material parts with high volume fraction, belonging to the field of metal materials. The preparation method is characterized in that the composite material comprises copper or copper alloy, diamond particles and an intermediate layer, wherein the volume fraction of the copper or the copper alloy is 32-45 percent, and the volume fraction of the diamond particles and the intermediate layer is 55-68 percent. The preparation method comprises the following steps of: firstly forming a TiC-Ti composite thin plating layer on the surface of the diamond by adopting a vacuum salt bath plating method, then adding an appropriate amount of caking agent into modified diamond powder and pressing into a porous prefabricated blank according to the shape of the parts; and finally putting the porous prefabricated blank and the copper or the copper alloy into a vacuum condition together for carrying out pressureless infiltration treatment to obtain the diamond-copper composite material parts with high volume fraction and high density. The invention has the advantages that the diamond-copper composite material parts with high volume fraction and the complex shape can be directly prepared, and the composite material parts have high density, even tissue distribution and low production cost, and can realize large-batch production.
Owner:UNIV OF SCI & TECH BEIJING
Device and method for determining border of target region of medical images
InactiveUS20150023578A1Improve and enhance accuracyAchieve correctionImage enhancementImage analysisTissue distributionRegion of interest
The invention discloses a device for determining a border of a target region of a medical image, which is used for differentiating the border of the target region according to corresponding physical quantitative properties reflected by tissue distribution in the medical image. The device comprises: an interactive unit, by which an operator can select the target region on the medical image; a threshold setting unit, which determines threshold values of the physical quantitative properties in the target region selected; and a thresholding segmentation unit, which divides the region to be analyzed or the region of interest into sub-regions, or fills image cells (pixels) in the region to be analyzed, wherein the region to be analyzed contains the target region, and the sub-regions are the sub-regions which are segmented in the image. The thresholding segmentation unit compares average parameter values of the physical quantitative properties of each sub-region with the threshold values and marks all the cells according to comparison results. The present invention provides a calculating and processing method and a device with clear physical significance and a simple and effective algorithm, and the method and the device are particularly suitable for processing special situations of various hearts with pathological changes in clinical art.
Owner:HONGEN HANGZHOU CHINA MEDICAL TECH +1
Liposomal Composition for Convection-Enhanced Delivery to the Central Nervous Centre
ActiveUS20110274625A1Improved tissue distributionConvection-enhanced delivery (CED)BiocideNervous disorderPhospholipidDrug release
Convection-enhanced delivery (CED) is used as a method to deliver a direct infusion of therapeutic agents to the central nervous centre thus circumventing the blood-blood barrier. A non-PEGylated liposomal composition comprising at least one saturated neutral phospholipid and at least one saturated anionic phospholipid and a therapeutic or diagnostic agent encapsulated therein is used to overcome toxicity associated with high peak drug concentration delivered locally CED as well as to increase tissue distribution volume for an improved sustained drug release. In one embodiment, the liposome composition comprises a molar ratio of DSPC:DSPG:CHOL of 7:2:1 and the therapeutic or diagnostic agent is selected from topotecan, conotoxin, gadodiamide or rhodamine, and is used in the treatment of epilepsy
Owner:MEDGENESIS THERAPEUTIX INC
Steel pipe continuous quenching process control method based on numerical simulation
ActiveCN104212969ASmall temperature differenceReduce consumptionIncreasing energy efficiencyFurnace typesElement analysisInduction hardening
The invention relates to a steel pipe continuous quenching process control method based on numerical simulation. The method comprises the following steps that initial technological parameters of the continuous induction quenching process are calculated according to the moving linear speed and quenching cooling water spraying pressure of a steel pipe, and the initial technological parameters comprise a heating process technological parameter and a quenching process technological parameter; finite element analysis is carried out on the steel pipe continuous induction heating process, and the relation between the heating process technological parameter and the internal and external surface temperature of the steel pipe is obtained; finite element analysis is carried out on the steel pipe quenching cooling process, and the relation between the quenching process technological parameter and the steel pipe tissue distribution condition is obtained; according to the process control requirement, the heating process technological parameter and the quenching process technological parameter conforming to the technological control requirement are obtained, and a final steel pipe continuous induction quenching process control parameter is formed; the obtained control parameter is used for controlling the actual steel pipe continuous quenching process. Compared with the prior art, the method has the advantages of reducing energy consumption caused by technological parameter determining through preproduction, improving the working efficiency and the like.
Owner:SHANGHAI JIAO TONG UNIV
Honokiol nanoparticles and preparation method thereof
InactiveCN103705469AImprove tissue distribution in the bodyImproved drug distributionAntibacterial agentsPowder deliveryFreeze-dryingIntravenous drug
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
Myricetin nanosuspension and preparation method thereof
InactiveCN103083235AAvoid destructionImprove propertiesAntibacterial agentsOrganic active ingredientsSolubilityPolymer science
The invention belongs to the technical field of medicines and relates to a myricetin nanosuspension and a preparation method thereof. The myricetin nanosuspension is prepared by adopting a settling method and a high-pressure homogenization method, and the formula comprises myricetin and a stabilizer according to the weight ratio of 1: 0.25-1: 2.5. According to the preparation method provided by the invention, the formula is optimized, Tween-80, Cremophor EL and D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) are screened as the stabilizer, the prepared myricetin nanosuspension has stable nature and simple composition of the formula, the preparation process is simple, convenient and feasible, and the particle size range is 100nm-300nm; and by reducing the particle size of a medicament, the solubility and the dissolution of the myricetin are obviously improved, and the oral bioavailability and the in-vivo tissue distribution of the myricetin are further improved. In addition, the myricetin nanosuspension can be freeze-dried, and proper excipients are added into the obtained freeze-dried powder for further preparing oral liquid, tablets, granules, capsules and other different oral preparations so as to facilitate clinical applications.
Owner:SHANGHAI UNIV OF T C M
Preparation method of silicon nitride-titanium carbonitride micro-nano composite material
The invention discloses a preparation method of a silicon nitride-titanium carbonitride micro-nano composite material. The preparation method comprises steps as follows: nano silicon nitride, nano titanium carbide and submicron titanium carbonitride powder are added to a submicron-grade silicon nitride matrix, MgO and Y2O3 are added and serve as sintering aid, and the composite material with relatively high obdurability and hardness is prepared through a reasonable sintering process, wherein the length-diameter ratios of silicon nitride crystal particles are distributed in a bimodal manner, and the sizes of the crystal particles are normally distributed. The material is uniform in tissue distribution, and the bending strength, the breaking tenacity, the hardness and the thermal shock resistance are improved obviously.
Owner:SHANDONG JIANZHU UNIV
Super-high strength cold rolled steel belt suitable for rolling formation and manufacture method of super-high strength cold rolled steel belt
The invention provide a super-high strength cold rolled steel belt suitable for rolling formation and a manufacture method of the super-high strength cold rolled steel belt. The super-high strength cold rolled steel belt comprises the following ingredients by weight percent: 0.12 to 0.18 percent of C; 0.1 to 0.4 percent of Si; 0.4 to 0.9 percent of Mn; 0.001 to 0.003 percent of B; 0 to 0.015 percent of P; 0 to 0.004 percent of S; 0.003 to 0.008 percent of N; 0.02 to 0.06 percent of Ti; 0.015 to 0.045 percent of Al; 0.002 to 0.006 percent of Ca; and Fe and unavoidable impurities in balancing amount. Through a reasonable ingredient design and a process design, the super-high strength cold rolled steel belt suitable for rolling formation is obtained; the tissue distribution is uniform; the performance uniformity is high; and a steel belt-type tissue is light and small, so that the cold bending performance is high. Moreover, the hardenability is moderate; the weld joint strength of the super-high strength cold rolled steel belt after being welded is approximately the same as that of a base metal; and the content of Si in the super-high strength cold rolled steel belt is lower, so that the surface quality of the super-high strength cold rolled steel belt is better, which meets the requirements for rolling and manufacturing vehicle components.
Owner:BAOSHAN IRON & STEEL CO LTD
Method of estimating specific absorption rate
InactiveUS20150185298A1Extended operating rangeImprove image qualityDiagnostic recording/measuringSensorsMedicineElectromagnetic field
The invention describes a method that provides a practical means of accurately estimating the electromagnetic fields and therefore the SAR (specific absorption rate) distributions of a subject in magnetic resonance imaging (MRI) scan. The disclosed method consists of several steps. If the coil information is unavailable during the patent imaging, the first step, generally performed before patient (or target) imaging, estimates the geometry of the radiofrequency (RF) coils. The second step estimates the patient-specific tissue volumes by deforming an appropriate reference with known tissue distribution from a database to the said target. Finally, the electromagnetic fields and the SAR distributions are calculated using numerical methods performed on the accurately estimated RF coils and patient-specific tissue volumes. The proposed method can be used for safe, accurate MR imaging at any magnetic field strengths, particular suitable for high-field applications.
Owner:THE UNIV OF QUEENSLAND
Method for preparing nano-multiple phase calcium phosphate/fibroin protein composite bracket
InactiveCN101293114AUniform biological propertiesMaintain biological activityProsthesisApatiteCytoskeleton
A preparation method of nanometer multiphase calcium phosphate / fibroin protein composite bracket relates to a preparation method of tissue engineering cytoskeleton. The existing preparation technology has the defects that organic solvent goes against the introduction of active material, sealed stomata goes against the growth of osseous tissue, low mechanical strength is unsuitable for bearing bone reparative regeneration and tissue distribution is uneven. The method provided by the present invention includes: a. calcium-deficient nanometer hydroxyapatite powder is synthesized by the effect offibroin organic template; b. pore-foaming agent sintering technique is adopted to crack the calcium-deficient nanometer hydroxyapatite powder after press molding for further preparation of nano-porous multiphase calcium phosphate ceramic matrix, the sintering temperature is 900 to 1,100 DEG C, the time is 2 to 3 hours and the pore-foaming agent is fibroin powder with the gain diameter of 90 to 300Mum; c. the matrix is dipped in 1 to 5 percent fibroin solution, frozen and dried to obtain the nanometer multiphase calcium phosphate / fibroin protein composite bracket material. The low-temperature sintering of the method provided by the present invention maintains the biological activity of the ceramics and overcomes the defects of the existing technology.
Owner:JIAMUSI UNIVERSITY
Friction welding process heat flow microstructure multi-physical field numerical calculation method
ActiveCN106202803ARealize multi-physics direct coupling numerical simulation calculationAccurate simulation calculation resultsData processing applicationsComputer aided designPhysical fieldNumerical models
The invention discloses a friction welding process heat flow microstructure multi-physical field numerical calculation method, which comprises a first step of building a heat flow coupling numerical model: performing temperature and flow field full coupling calculation by using an Euler method which takes temperature into account so as to obtain the size and distribution ofthe temperature and the flow field at any time during a workpiece welding procedure; a second step of performing microstructure transformation calculation by using a Leblond phase transformation model and algorithm so as to obtain phase transformation tissue distribution; a third step of building a heat flow microstructure coupling numerical model based on the obtained temperature, flow field and the phase transformation distribution, and calculating a workpiece plastic zone and stress-strain during the welding procedure. When the method disclosed by the invention is used for simulating a friction welding process, a simulation result can be obtained efficiently and exactly, and the fit degree to an actual friction welding process can be increased.
Owner:SICHUAN UNIV
Steel for saw web and hot rolled steel plate production method thereof
The invention discloses steel for a saw web and a hot rolled steel plate production method thereof. The steel for the saw web comprises the chemical compositions of, by mass, 0.73-0.77% of C, 0.16-0.26% of Si, 0.80-1.20% of Mn, no larger than 0.03% of P, no larger than 0.03% of S, 0.005-0.020% of Als, 0.0008-0.0022% of Ca, 0.35-0.49% of Cr, 0.11-0.20% of V, and the balance Fe and unavoidable impurities; and the production method comprises the following processes of smelting, continuous casting, heating, rolling and straightening. The plasticity and toughness of steel plates manufactured by thehot rolled steel plate production method are improved, the tissue distribution is even, the shape, dimensional precision and surface quality are improved, and wear-resisting property and fatigue strength are good, and the steel plates are suitable for manufacturing thicker saw webs.
Owner:TANGSHAN IRON & STEEL GROUP +1
High-heat-conduction near-net-shaped diamond/copper composite and preparing method thereof
The invention discloses a high-heat-conduction near-net-shaped diamond / copper composite and a preparing method thereof, and belongs to the field of metal materials. The diamond / copper composite is of a three-dimensional communication structure and is composed of a diamond particle framework, a transition layer, metal copper and surface seepage copper; the preparing method comprises the steps that diamond particles subject to salt-bath plating W are subject to near net shaping, and a pressure-free infiltration method is adopted to prepare the high-heat-conduction composite. The method effectively solves the problems about compatibility of diamond and metal, difficult machining of the diamond / copper composite, poor surface quality, single product shapes, high production cost and the like; the prepared composite is high in compactness, uniform in structure distribution, controllable in interface thickness, high in heat conduction rate, simple in process device, high in operation, low in energy consumption cost, capable of being produced in a large-batch manner, and capable of meeting the requirement of the heat management or electronic package field and has the high heat conduction property.
Owner:GUANGDONG ZHENGDE MATERIAL SURFACE TECH
Prediction method for titanium alloy die forging part basket-weave microstructure distribution
ActiveCN108977741AIncrease production costOptimizing the forming processDesign optimisation/simulationSpecial data processing applicationsThermal compressionFinite element software
The invention provides a prediction method for titanium alloy die forging part basket-weave microstructure distribution. The prediction method comprises the following steps: S1, performing tissue teston a material under different deformation conditions; S2, obtaining rheological curve through thermal compression deformation experiments under different deformation parameters, obtaining a constitutive model capable of predicting titanium alloy deformation resistance through numerical analysis and simultaneously analyzing effects of deformation parameters on a microstructure evolvement rule; S3,establishing critical criterion; S4, establishing a visual prediction model of die forging part basket-weave microstructure distribution through finite element software secondary development based onthe critical technological conditions of basket-weave microstructure formation and comparing, analyzing and verifying the visual prediction model with actual results. The established prediction method for titanium alloy die forging part basket-weave microstructure distribution disclosed by the invention disclosed by the invention can effectively reveal microstructure change of titanium alloy after forged hardening and can predict basket-weave tissue distribution in forged pieces under the certain conditions.
Owner:YANSHAN UNIV +1
Full-automatic multiple-column four-edge-sealing disposable tableware packing machine
The invention relates to a full-automatic multiple-column four-edge-sealing disposable tableware packing machine. The full-automatic multiple-column four-edge-sealing disposable tableware packing machine comprises material feeding rails and tissue feeding-in equipment, chopstick feeding-in equipment, spoon or fork feeding-in equipment and toothpick feeding-in equipment, wherein the material feeding rails are arranged in multiple columns, a tissue distribution device is arranged between the tissue feeding-in equipment and the material feeding rails, the tissue distribution device comprises supports, a tissue placing box, a plug board and placing box guide rails, the plug board is provided with a tissue distribution driving mechanism for driving the plug board to move below the tissue placing box and is provided with a pushing component for pushing the tissue placing box to move on the placing box guide rails, the tissue placing box is provided with a reset part for resetting the tissueplacing box after the pushing component is released, and the supports are provided with a positioning component for positioning the resetting position of the tissue placing box. The technical scheme of the full-automatic multiple-column four-edge-sealing disposable tableware packing machine has the technical effect of improving the packing efficiency effectively.
Owner:PINGYANG HAIHANG MACHINERY
Rafamycin analogs and methods for making same
A semi-synthetic rapamycin analog with a triazole moiety or a pharmaceutically acceptable salt or prodrug thereof, is a broad-spectrum cytostatic agent and a mTOR inhibitor, and is useful in the treatment of various cancers, or tumors in organs such as kidney, liver, breast, head and neck, lung, prostate, and restenosis in coronary arteries, peripheral arteries, and arteries in the brain, immune and autoimmune diseases. Also disclosed are fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosois, post-transplant tissue rejection, and immune and autoimmune disease in a mammal. One particular preferred application of such triazole-moiety containing rapamycin analog is in treating renal carcinoma, lung cancer, colon cancer, and breast cancers wherein potency of the drug, its half-life, tissue distribution properties, and its pharmacokinetic properties including bioavailability through oral and intravenous routes are essential to the clinical outcomes.
Owner:HANGZHOU ZYLOX PHARMA
Alprostadil lipid nanosphere freeze-drying injection and preparation method thereof
ActiveCN102228446AStable physical stabilityImprove stabilityOrganic active ingredientsPowder deliveryPulmonary vasculatureDisease
The invention discloses an alprostadil lipid nanosphere freeze-drying injection and a preparation method thereof, and belongs to the technical field of medicines. The alprostadil lipid nanosphere freeze-drying injection is prepared from the following raw materials in part by weight: 0.0005 to 0.1 part of alprostadil, 15 to 60 parts of medium-chain oil, 3.0 to 35 parts of emulsifier, 8.5 to 48 parts of polyethylene glycol-12-hydroxy stearate, 22 parts of glycerol, 20 to 200 parts of trehalose, and 20 to 300 parts of cyclodextrin. The particle size of the alprostadil lipid nanosphere freeze-drying injection after redissolution is less than 100nm; and an aseptic filtration way can be used for sterilization, so that the disadvantage of thermal instability of the alprostadil is overcome, and the stability of products is improved. Meanwhile, lipid nanospheres have smaller particle sizes which are less than 100nm, so the alprostadil lipid nanosphere freeze-drying injection is more favorable for the distribution of the alprostadil in in-vivo non-reticuloendothelial system (RES) tissues, reduces pulmonary circulation inactivation and blood clearance, is favorable for circulating in vivo for a long time, and is suitable for the treatment of cardiac and neurosurgical diseases.
Owner:SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
Deep conical copper shaped charge liner tissue ultrafine crystallization gradient control method
ActiveCN108517477AImprove plasticityEvenly distributedExplosive chargesTissue distributionSuperficial mass
The invention provides a deep conical copper shaped charge liner tissue ultrafine crystallization gradient control method, which comprises the steps of extrusion shaping, re-crystallization heat treatment and high-frequency percussion, wherein in the extrusion shaping step, multi-pass extrusion is used; the high-frequency impact knocking speed is 15000 to 40000 times / minute; the knocking force is1200 to 2000 N; the times is 1 to 3 times. The control technology provided by the invention realizes the deep conical copper shaped charge liner shaping and surface quality control; the material plasticity is improved; the fine crystal tissues can be obtained; the ultrafine crystal gradient tissues distributed in the thickness direction are formed on the surface layer in the charge shaped liner. The ultrafine crystal gradient tissues distributed in the thickness direction of the charge shaped liner are obtained by using the method; the tissue distribution in the bus direction is uniform; a novel preparation method is provided for the invention of the high-performance deep conical copper shaped charge liner.
Owner:NO 59 RES INST OF CHINA ORDNANCE IND
Antineoplastic nanometer heat sensitive target medicine carrier used combined with chemical therapy and heat therapy
InactiveCN1720996ASolve the defect of low distributionAddresses the defect of activity changePharmaceutical non-active ingredientsAntineoplastic agentsChemical LinkageMedicine
The invention relates to an antineoplastic nanometer heat sensitive target medicinal carrier used combined with chemical therapy and heat therapy, wherein the nano heat-sensitive targeting medicinal carrier employs amphiphilic segmented copolymer micelle, the hydrophobic fragments form inner cores, the hydrophilic fragments form outer-shells, the outer-shells surround the inner cores. the hydrophilic fragments comprise heat-sensitive polymers with a low critical solution temperature at 37-42 deg. C, the hydrophobic fragments comprise polylactic acid. The invention can avoid the injury to normal human tissue cells by chemotherapy medicaments.
Owner:THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
Connection method for thick plate TiNi alloy and titanium alloy dissimilar materials
ActiveCN107414279AHigh melting pointIncrease energy densityElectron beam welding apparatusWelding/soldering/cutting articlesCrazingThick plate
The invention discloses a connection method for thick plate TiNi alloy and titanium alloy dissimilar materials. The connection method comprises the following steps that a TiNi alloy is subjected to acid pickling to the specified thickness; abrasive paper is used for grinding welded end faces of the dissimilar materials till the welded end faces are level; the position between the butt-joint materials is filled with Nb bars, and a clamp is used for fixing the welding materials; and finally the clamp and the welding materials are fed into an electronic beam equipment vacuum chamber together, electronic beams deviate to one side of a titanium alloy for welding, and a welding joint high in strength and good in comprehensive mechanical performance is obtained. According to the welding method, cracks generated by thick plate TiNi alloy and titanium alloy welding are eliminated; forming of Ti2Ni and other brittle intermetallic compounds is hindered; structure distribution is uniform, and grains are finer; and the strength of extension of the scanning welding joint reaches 551 MPa, the joint toughness is good, good comprehensive performance is achieved, and large engineering significance is achieved.
Owner:NANCHANG HANGKONG UNIVERSITY
Single-sided internal oxidation silver tin oxide indium oxide electric contact material and preparation method thereof
The invention discloses a single-sided internal oxidation silver tin oxide indium oxide electric contact material which comprises a silver tin oxide indium oxide material body. One side of the silvertin oxide indium oxide material body is a solder surface with a solder. The solder surface is composed of an AgSn layer or an AgZn layer. The other side of the silver tin oxide indium oxide material body is an oxidation surface. The oxidation surface is an AgSnO2In2O3 layer. The invention further provides a preparation method of the material. According to the acquired single-sided internal oxidation silver tin oxide indium oxide electric contact material, subsequent welding is convenient and reliable; the acquired silver tin oxide indium oxide is single-sided oxidation, which prevents an intermediate 'lean oxide' area; and tissue distribution is even.
Owner:ZHEJIANG UNIV +1
Preparation method of graphite-ball-enhanced aluminium-based composite material with high heat-conductivity isotropy
The invention discloses a preparation method of a graphite-ball-enhanced aluminium-based composite material with high heat-conductivity isotropy, and belongs to the field of metal materials. The aluminium-based composite material contains the following components according to volume fraction: 40%-80% of pure-aluminium powder and 20%-60% of graphite ball. The production process comprises the following steps: firstly mixing the pure-aluminium powder and the graphite ball powder according to corresponding volume-fraction proportion, then placing the mixed powder into a graphite mold together to carry out spark plasma sintering, and thus obtaining the graphite-ball-aluminium-based composite material with high volume fraction, high heat conductivity, high density and approximate isotropy. The preparation method disclosed by the invention has the beneficial effects that the prepared graphite-ball-aluminium-based composite material with high heat conductivity and approximate isotropy is highin density and uniform in tissue distribution, and can realize large-batch production, low production cost and high practical level. The heat conductivity of the aluminium-based composite material isapproximately isotropic, and can reach 227.61W.m<-1>.k<-1> in the X and Y directions and 187.27W.<-1>.k<-1> in the Z direction. The heat expansion coefficient fluctuates between 6.4-10.6*10-6K<-1> under the room-temperature condition and the density can reach more than 98%.
Owner:UNIV OF SCI & TECH BEIJING
Nanosuspension of annonaceous acetogenin drugs and preparation method of nanosuspension
ActiveCN106420604AEasy to achieve passive targetingSimple prescriptionPowder deliverySolution deliverySide effectAnnonaceous Acetogenins
The invention belongs to the technical field of medicines, and in particular relates to a nanosuspension of annonaceous acetogenin drugs prepared from such amphiphilic stabilizers as mPEG PCL, mPEG PLA, mPEG PLGA, mPEG DSPE, mPEG Chol, SPC, Tween80, BSA, TPGS and the like, as well as a preparation method and an application of the nanosuspension. The annonaceous acetogenin total lactone nanosuspension is prepared by virtue of a solvent precipitation-ultrasonic injection method, and according to a prescription, the proportioning ratio of the annonaceous acetogenin drugs to the stabilizer is at 1 to (0.02-10) (in percentage by weight). The prepared annonaceous acetogenin nanosuspension can reach a load-loading capacity to 90% to the greatest extent and can reach a minimum grain size to 123.2nm, and the nanosuspension is good in polydispersity. The nanosuspension is stable in both gastrointestinal fluid and plasma, and the nanosuspension is applicable to oral administration and injection administration; the nanosuspension has a good in-vitro sustained-release effect and is free from burst release; the nanoparticle, in comparison with a crude drug solution, is more obvious in tumor cell inhibitory rate in vitro; the nanosuspension, in in-vivo tissue distribution, shows tumor passive targeting; therefore, the nanosuspension is beneficial for enhancing efficacy and reducing toxic and side effects. Meanwhile, an in-vivo efficacy experiment shows that the nanosuspension is outstanding in antineoplastic efficacy, and the nanosuspension has a broad development prospect.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
Method and apparatus for quantitative analysis of breast density morphology based on MRI
A method and apparatus configured to analyze breast density based on magnetic resonance imaging (MRI) of a breast of a patient includes the steps of segmenting an MR image of the breast from one set of three-dimensional breast MRI images, and analyzing the amount of dense tissue and the morphological distribution of the dense tissue and a data processor configured by software to perform these steps. Analyzing the amount of dense tissue and the morphological distribution of the dense tissue includes the steps of segmenting tissue data to separate breast tissue from other body tissue, separating tissue data of the dense and fatty tissues in the breast, and analyzing the morphological distribution of dense tissue in the breast to derive one or more three dimensional morphological parameters of the dense tissue distribution.
Owner:RGT UNIV OF CALIFORNIA
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