Belonging to the field of medical technology, the invention discloses a compound for treatment of respiratory system diseases and a preparation method thereof, and specifically discloses a new erdosteine compound and a preparation method thereof. The erdosteine compound crystal's X-ray powder diffraction spectrum represented by a diffraction angle of 2theta+/-0.2 degrees shows characteristic diffraction peaks at the positions of 3.41 degrees, 6.51 degrees, 8.48 degrees, 9.91 degrees, 12.65 degrees, 21.89 degrees, 24.48 degrees, 26.15 degrees, 30.69 degrees, 33.24 degrees, 35.56 degrees, 36.09 degrees, 38.35 degrees and 39.40 degrees, and the X-ray powder diffraction spectrum obtained by Cu-Kalpha ray measurement is shown as figure 1. The erdosteine crystal provided by the invention is different from the existing technology, has good stability, good solubility, good flowability and compressibility, and can be mixed evenly with other auxiliary materials.