59results about How to "No first pass effect" patented technology

The invention discloses a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and relieving swelling and pain. The composition is prepared from the following 26 traditional Chinese medicines: pseudo-ginseng, angelica sinensis, parasitic loranthus, notopterygium root, radices sileris, bombyx batryticatus, caulis spatholobi, asarum, monkshood, radix achyranthis bidentatae, frankincense, myrrh, salviae miltiorrhizae, hematoxylon, ardisia quinquegona, dotted ardisia, leech, cudrania cochinchinensis, radix zanthoxyli, geranium wilfordii, herba lycopi, curcuma zedoary, fructus aurantii, daemonorops draco, nux vomica and borneol. The traditional Chinese medicine composition disclosed by the invention is capable of effectively relieving swelling and pain caused by bumps, bruises, blood stasis and joint function disturbance, and is convenient to use, fast in acting and significant in curative effect.

The invention relates to a curcumin compound dry powder inhaler as well as a preparation method and application thereof. The curcumin compound dry powder inhaler is a medicinal composition prepared by mixing a curcumin compound as an active constituent, and pharmaceutically acceptable auxiliary materials. Compared with orally drug administration, the effect of the curcumin compound dry powder inhaler developed according to the technical scheme provided by the invention on treating pulmonary fibrosis and lung tumors is greatly improved.

The invention discloses a traditional Chinese medicine preparation for treating gout and a preparation method thereof. The traditional Chinese medicine preparation is mainly made from the raw ingredient medicines by weight parts as follows: radix rehmanniae, pawpaw, Radix Aucklandiae, angelica dahurica, Wu Chia Pee, achyranthes and radix aconiti feri are respectively 100 to 250 parts; panax notoginseng and fennel are respectively 10 to 40 parts; camphor is 25 to 75 parts; borneol is 10 to 30 parts; mush / muskone is 0.1 to 0.5 parts. Compared with the prior art, the traditional Chinese medicine preparation has specific antiphlogistic effect to non-steroid inflammation, and has the functions of clearing heat as well as removing dampness, activating blood circulation and dredging collaterals, and promoting vascular regeneration; by adopting the modern extraction technology, the invention fully extracts the active ingredients in the traditional Chinese medicine to make a external preparation which can be applied on affected parts directly; through percutaneous absorption, no liver first pass effect occurs, the traditional Chinese medicine preparation has no damage to the liver, stomach, kidney, etc., without toxic and side effects, the curative effect is good and thorough, and the relapse is avoided.

The present invention relates to a medicine for curing diseases of respiratory tract, specially for curing asthma. In particular, it relates to a glucocorticoid hormone capsule type inhalation powder aerosol preparation and its preparation method. It is made up by mixing glucocorticoid hormone and carrier, the described carrier is lactose, glycine and mannitol or their mixture, and the average grain size of powder is 0.1-10 micrometers.

The invention discloses a mucosal disease treatment system. The mucosal disease treatment system comprises a biological adhesive, a biological medical material, and medical instruments, wherein the biological adhesive comprises the following components: a component a, namely a functionalized star polymer or / and a functionalized comb polymer, and a component b, namely functional polysaccharide; anactive group of the component a and an active group of the component b can chemically react to form a new chemical bond; the biomedical materials, which are selected according to different mucosal diseases, are mixed in the component a of the biological adhesive, or in the component b of the biological adhesive, or partially mixed in the component a of the biological adhesive and partially mixed in the component b of the biological adhesive. When the system is in use, one of the components a and b is covered on a mucous membrane to be treated with the aid of a corresponding medical instrument,and the other component is covered on the previous component; the biological adhesive is firmly adhered to the mucous membrane and seals and repairs the mucous membrane; and the biological medical material is continuously released into adhesive tissues, thereby treating mucosal diseases.

The invention discloses an eprinomectin transdermal agent, a preparation method and application. The eprinomectin transdermal agent is composed of azone, oleic acid, propylene glycol, dimethyl sulfoxide and alcohole with a certain weight amount. The preparation method comprises: A, performing sample preparation, namely, setting five levels for each transdermal promoting agent, and adding alcohol for preparing samples; B, performing in-vitro transdermal experiments, fixedly disposing skin of a white mouse between a dispersion pool and a receiving pool of a YB-P6 intelligent transdermal tester, enabling the inner layer surface of skin to face to the receiving pool, enabling the whole dispersion pool to be full with the eprinomectin transdermal-agent formula sample, and adding acetonitrile to fill the receiving pool as a receiving solution; C, detecting the receiving solution obtained in the step B by using high performance liquid chromatographic instrument, and selecting a formula through visual analysis and variance analysis on an orthogonal experiment result; D, preparing the formula and verifying according to the front steps; and E, preparing a final product, and preparing a transdermal agent containing 0.025-0.1 g of eprinomectin. The formula is reasonable, convenient to use and capable of continuously expelling parasites without needing withdrawal time, and has the expelling rate of 90% or more on nematode and ectoparasites.

The invention discloses netilmicin sulfate inhalation powder and a preparation method thereof. The powder consists of the following raw materials:, namely netilmicin sulfate or a mixture of the netilmicin sulfate and an amino acid glidant, wherein the weight ratio of the netilmicin sulfate to the amino acid glidant is 10-30:1. The method has the advantages that the preparation technology is simple, no organic solvent or preservative is used in the preparation process, the flowability of the prepared powder is greatgood, the deposit rate at effective parts is high, and the problems that the netilmicin sulfate has high water solubility and cannot be absorbed when isbeing orally taken are solved; and meanwhile, as the inhalation powder is used as a medicine performing a local function, the dosage of administration is obviously reduced, and the occurrence rate of side effects related to an aminoglycoside dosage, such as ototoxicity and renal toxicity is reduced.

The invention discloses a high-absorption full-component Cordyceps sinensis capsule and a lozenge as well as a preparation method thereof. The preparation method comprises the following steps: cleaning by using distilled water at 15 DEG C for 110 seconds through a Cordyceps sinensis professional cleaning tool, ensuring that each Cordyceps sinensis can reach a microscope grade cleaning degree; then performing cold disinfection at low temperature so that industrial raw material grade is left to a direct edible grade; performing ultramicro wall breaking and crushing, and releasing the nutrition component at maximum extent. Through ultramicro wall breaking treatment, the fasten cell wall is broken, elite component can be released at maximum extent, purity is 100%, effective nutrient composition absorptivity on Chinese caterpillar fungus by human body can reach more than 95%, usage efficiency is increased by at least 20 times, the Cordyceps sinensis is taken as the raw material, polypide and stroma can not be distinguished, according to the herbal medicine usage study, the Cordyceps sinensis has the efficacy of no toxicity, lung and ying benefiting, phlegm reducing and qi benefiting, haemostasis, and consumptive cough treatment.

The invention discloses a traditional Chinese veterinary medicine extract for promoting gastrointestinal peristalsis as well as a preparation and a preparation method thereof. The extract comprises the following extracts of raw materials in parts by weight: 1 part of areca nut ethanol extract, 1 part of hawthorn aqueous extract and 1 part of fructus amomi volatile oil; the preparation of the extract is injection liquid and comprises the extract and pharmaceutically acceptable vectors; and the preparation method comprises the following steps of: dissolving the areca nut ethanol extract and the hawthorn aqueous extract by adding water, standing, filtering, decoloring filtrate by using activated carbon and then cooling to 60 DEG C for later use; slowly adding the fructus amomi volatile oil, evenly grinding, then slowly adding 60-DEG C insulating liquid, grinding and emulsifying, then adding an antioxidant, a bacteriostatic agent, a metal chelating agent and water for injecting, regulating pH to be 4.5 to 5.5 by using a pH regulating agent, standing, filtering, encapsulating and sterilizing to obtain the product. The extract and the preparation thereof have remarkable effect of prompting the gastrointestinal peristalsis, are simple in preparation method, low in cost and can be used for treating livestock indigestion.

The invention relates to dry powder inhalation, in particular to the dry powder inhalation prepared by senso fat-soluble extract, a preparation method of the dry powder inhalation and application in preparing a medicament for treating lung tumors. The senso fat-soluble extract dry powder inhalation is characterized by consisting of senso fat-soluble extract and pharmaceutically acceptable auxiliaries in the mass ratio of 1:0-1:100. The senso fat-soluble extract is made into the dry powder inhalation, and can directly act on a lung focus to reduce occurrence of toxic and side effects and improve the bioavailability of the medicament, so that the defects of slow response, first pass effect of hepar and systemic toxic and side effect, low bioavailability and the like of oral preparations canbe overcome, and the problems of inconvenient use of injection, poor patient compliance and the like can be solved.

The invention belongs to the field of medicines and particularly relates to a dry potassium sodium dehydroandrographolide succinate powder inhalation and a preparation method thereof. The dry potassium sodium dehydroandrographolide succinate powder inhalation is prepared by mixing superfine potassium sodium dehydroandrographolide succinate powder and lactose micropowder, wherein the mass ratio of the superfine potassium sodium dehydroandrographolide succinate powder to the lactose micropowder is (1:6)-(1:2), the average particle size of the superfine potassium sodium dehydroandrographolide succinate powder is 1-5mu m, and the maximum particle size of the superfine potassium sodium dehydroandrographolide succinate powder doses not exceed 10mu m; the average particle size of the lactose micropowder is 60-80mu m, and the maximum particle size of the lactose micropowder is 60-80mu m. The dry potassium sodium dehydroandrographolide succinate powder inhalation provided by the invention can be autonomously and actively inhaled by a patient through an inhalation device and is delivered to the lung to take effects, so that the toxic or side effect of the dry potassium sodium dehydroandrographolide succinate powder inhalation to the whole body is reduced; the dry potassium sodium dehydroandrographolide succinate powder inhalation can be autonomously inhaled without the help of the medical staff so as to be convenient to use; and the medical staff is low in preparation cost and relatively low in clinical application price.

The invention discloses a traditional Chinese medicine composition for treating a bone fracture. The composition is prepared from the following 23 traditional Chinese medicines: tinospora sinensis merr, heterosmilax japonica, smalt, pegia sarmentosa, flemingia philippinensis, gynostemma pentaphylla, aituoduo (Chinese character), herba periliae, asclepiadaceae tylophora koi, sinoadina racemosa, herba chloranthi serrate, clerodendrum serratum var amplexifolium, rhinacanthus nasutus, blumea balsamifera, sambucus chinensis, girardinia diversifolia, red elecampane, ardisia mamillata hance, uncaria rhynchophylla, rhizoma smilacis glabrae, tongking pepper, drynaria total flavonoids and epipremnum pinnatum. The traditional Chinese medicine composition works together to achieve the efficacies of promoting reunion of fractured bones, promoting blood circulation to remove blood stasis, relieving swelling and pain, soothing the channels and activating collaterals, has significant curative effects on treatment of the bone fracture, and can also be applied to soft tissue injuries, ligament and joint strain injuries caused by falling, hitting, touching, knocking and the like; and the symptoms such as local pain, tumidness, dysfunction, black and blue subcutaneous addiction spots or hematoma of patients are removed.

The preparation method of rifampicin injection includes the following steps: slowly adding 300g of rifampicin into 1000ml of mixed solution under the condition of continuously stirring, said mixed solution is made up by mixing (by volume ratio) 0.75-1.2% of chemical inhibitor anhydrous sodium sulfite, 0.01-0.05% of metal ion complexing agent disodium ethylene diamine tetraacetate and 98.75-99.2% of organic solvent propylene alcohol, stirring them for 10-20 min, slowly drop-adding 5% NaOH under the condition of stirring, regulating pH to 6.5-9.0, adding active carbon for injection, stirring for 10 min, filtering to remove carbon, filtering by means of microporous filtering film, making constant volume to 5000ml, filling into glass ampule, charging nitrogen gas, sealing, sterilizing for 30 min by means of flowing steam with 100deg,C. cooling, checking and packaging.

The invention provides a stable ambroxol theophylline acetate solution for inhalation and belongs to the field of chemical pharmaceuticals. The stable ambroxol theophylline acetate solution comprises theophylline acetic acid, ambroxol hydrochloride, a surfactant, an antioxidant, and a preservative. Furthermore, 100 ml of solvent contains 0.1-0.3 g of theophylline acetic acid, 0.1-0.3 g of ambroxol hydrochloride, and the surfactant accounting for 3-6% of the theophylline acetic acid by weight, and pH of the solution is 2.0-5.8. The stable ambroxol theophylline acetate solution for inhalation in the invention is good in stability and long in storage time. This solution may have no significant change in active ingredients after being stored at room temperature for one year.

The invention provides a chronic skin ulcer treating medicine for external application and a preparation method of the chronic skin ulcer treating medicine for external application. The chronic skin ulcer treating medicine for external application is mainly prepared from, by weight, 100-300 parts of Radix Astragali, 30-100 parts of Cortex Cinnamomi, 30-100 parts of Rhizoma Ligustici Wallichii and 1-3 parts of musk. The medicine for external application is high in wound healing rate of chronic skin ulcer and has advantages of formulation simplicity, directness to lesions, freeness of first pass effect and the like.

A traditional Chinese medicine composition for treating gallbladder polyps and gallstones is characterized by consisting of the following raw materials according to the proportioning by weight: glossy privet fruit: yerbadetajo herb is equal to 0.2-5:5-0.2. The traditional Chinese medicine composition has the advantages that tablets have accurate dosage, small content difference, stable quality, protection with the help of coating and less impacts caused by light, air, water and the like; granules have small gastrointestinal irritation, big load of medicine, good taste and easy acceptance; oral liquid has rapid absorption, high bioavailability and is used by a wide scope of people; injections have high bioavailability, quick pick-up, no first pass effect and the ability of being applicable to patients who are not applicable to oral administration; sustained and controlled release preparations have convenient use and can provide the balanced and durable effective blood drug concentration, thereby being particularly applicable to the patients with the need of long-term medication.

The present invention discloses a curcumin powder mist inhalation preparation. The curcumin powder mist inhalation preparation comprises the following raw materials: curcumin, a lipid material, polyoxyethylene stearate, poloxamer 188, Tween-80, a freeze-drying protective agent, lactose and water. A preparation method is as follows: (1) respectively weighing the raw materials; (2) adding the curcumin, lipid material and polyoxyethylene stearate into absolute ethanol to dissolve to obtain an organic phase; (3) adding the poloxamer 188 and Tween-80 into water to be dissolved to obtain a water phase; (4) adding the organic phase to the water phase to remove the absolute ethanol; (5) adding into cold water, keeping stirring in a cold water bath and conducting filtering; (6) adding the freeze-drying protective agent to conduct freeze-drying; and (7) adding the lactose and conducting sieving to obtain a finished product. Propellants and solvents are not used, airflow is relied to enable medicinal powder to be atomized, thus the medicinal powder is transferred to the lungs, and the curcumin powder mist inhalation preparation has characteristics of convenient application, rapid absorption and targeted positioning.

The present invention relates to a trimebutine maleate injection and a preparation method thereof. The trimebutine maleate injection comprises a pharmaceutical active component of trimebutine maleate, and an additional preparation adjuvant, wherein 1 ml of the trimebutine maleate injection contains 5-20 mg of the trimebutine maleate, the additional preparation adjuvant comprises 0.1-2% of an analgesics, 0.5-1.5% of an osmotic pressure regulator, and the balance of water. The trimebutine maleate injection of the present invention has characteristics of quick onset, first pass effect-free property, high bioavailability and simple preparation method.

The invention discloses a traditional Chinese medicine composition for treating gout, traumatic injury and arthralgia. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 20 to 40 parts of radix araliae armatae, 20 to 30 parts of radix cynanchi paniculati, 20 to 30 parts of cinnamomum camphora, 10 to 30 parts of Chinese angelica, 10 to 30 parts of rhizoma pleionis, 20 to 30 parts of herba centellae, 10 to 30 parts of entadae stem, 10 to 20 parts of radix et rhizoma clematidis, 10 to 20 parts of radix zanthoxyli, 10 to 20 parts of radix gentianae macrophyllae, 10 to 15 parts of bauhinia championii, 10 to 20 parts of caulis piperis kadsurae, 5 to 15 parts of radix angelicae pubescentis, 5 to 15 parts of radix notoginseng, 5 to 15 parts of flos carthami, 5 to 15 parts of ramulus cinnamomi, 5 to 15 parts of rhizoma curcumae longae, 3 to 8 parts of olibanum, 3 to 8 parts of myrrha, 1 to 3 parts of herba asari and 0.5 to 1.5 parts of menthol. The traditional Chinese medicine composition disclosed by the invention has the effects of soothing channels, activating collaterals, dispelling wind, eliminating dampness, relieving swelling and stopping pain and can be used for treating diseases of the gout, the traumatic injury, the arthralgia and the like. A spray prepared by the invention has the advantages that the effects can be conveniently and rapidly obtained, the medicine efficacy is durable, the application is simple and convenient, and the like.

The invention discloses a traditional Chinese medicine preparation for treating bone trauma blood stasis swelling and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines and preparations. The preparation method of the traditional Chinese medicine preparation comprises the following steps: weighing the following traditional Chinese medicinal materials according to a specific mass ratio: buckwheat flour, white mulberry root-bark, garden burnet root and coix seed, drying, uniformly mixing, crushing to obtain a fine material, adding an acetic acid aqueous solution with the mass concentration of 1-5% according to a ratio of 1kg: 3000-7000mL, uniformly stirring, and decocting with slow fire until a pasty formed ointment is formed, thereby obtaining the traditional Chinese medicine preparation. The traditional Chinese medicine preparation disclosed by the invention can obviously relieve pain of bone fracture diseases such as fracture and the like, can quickly reduce swelling and remove blood stasis, shorten the course of disease and relieve pain of patients, and can play a role in external fixation on fracture patients after being completely dried and fixed as an external ointment.

The invention relates to a dry powder inhaler, and in particular relates to a dry powder inhaler prepared from toad venom lipophilic extract, a preparation method of the dry powder inhaler and an application of the dry powder inhaler in preparing a medicament for treating lung tumors. The toad venom lipophilic extract dry powder inhaler is characterized by consisting of toad venom lipophilic extract and pharmaceutically acceptable auxiliary materials in a mass ratio of 1:0-1:100. According to the dry powder inhaler, the dry powder inhaler prepared from the toad venom lipophilic extract can be used for directly acting on the focus of the lung, so that the occurrence of toxic or side effect can be reduced, and the bioavailability of the medicament can be improved. The dry powder inhaler can be used for overcoming the defects that an oral preparation is slow in response, has first-pass effect of liver and systemic toxic or side effect, low in preparation bioavailability, and can be used for solving the problems of using inconvenience, poor patient compliance and the like.

The invention provides a compound preparation containing mesalazine and acetaminophen. The compound preparation is an enema, which comprises 4 g of mesalazine, 0.2-0.65 g of acetaminophen, 0.04-0.1 gof a metal chelator, 0.1-0.5 g of an antioxidant, 0.01-0.2 g of a preservative, 0.1-0.4 g of a suspending agent, 0.1-0.4 g of a pH regulator, and the balance of purified water to 60g. The invention also provides a preparation method and application of the above compound preparation. The compound preparation has stable and uniform product quality, improves the effectiveness and safety of patient'smedication, has good therapeutic effect on ulcerative colitis and has good analgesic effect.

The invention relates to the technical field of medicine, in particular to a mogroside aerosol and a preparation method thereof. The mogroside aerosol is prepared by mixing ultrafine powder of mogroside and fine powder of lactose, wherein the mass ratio of the ultrafine powder of mogroside to the fine powder of lactose is 1 to (2 to 6). The mogroside aerosol has the beneficial effects that the mogroside inhalation powder aerosol can be autonomously and actively inhaled by patients through an inhalation device, the medicine is transported to the lungs to take effect, and the systemic toxic andside effects of the medicine are reduced; inhalation can be autonomously performed without the help of medical staff, and the mogroside aerosol is convenient to use; and the preparation cost is low, and the clinical use price is relatively low.

The invention provides a sumatriptan pharmaceutical composition used in the nasal cavity, which comprises sumatriptan and corresponding excipients. The sumatriptan pharmaceutical composition disclosed by the invention has the advantages of simple formula, low cost, great efficacy for treating migraine and effects of saving cost and improving the efficacy.

The invention belongs to the field of medicines, and particularly relates to an erdosteine powder inhalation which is actively inhaled in a superfine powder mode and directly delivers a medicine to the lung to exert effect, solving the problem of low degradation effect and liver first pass elimination effect bioavailability of a medicine in gastrointestinal tracts. The erdosteine powder inhalation is prepared by mixing superfine erdosteine powder and superfine poloxamer 188 powder, wherein the average particle size of the superfine erdosteine powder at the weight ratio of 20:3-2:1 is 1-5 micrometers, and the maximum particle size is not more than 10 micrometers; the average particle size of the superfine poloxamer 188 powder is 60-80 micrometers, and the maximum particle size is not more than 100 micrometers. A preparation method comprises the following steps: grinding erdosteine, carrying out superfine crushing by using a superfine crusher to obtain the superfine powder of which the average particle size is 1-5 micrometers; carrying out superfine crushing on poloxamer 188 by using the superfine crusher to obtain the superfine powder of which the average particle size is 60-80 micrometers; and uniformly mixing the crushed superfine powder according to a proportion of 20:3-2:1, and then subpackaging.

The invention discloses a traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and relieving pain. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 18-25 parts of clove, 10-20 parts of galangal, 10-23 parts of pepper, 10-20 parts of long-noded pit viper, 10-17 parts of fennel, 10-20 parts of illicium verum, 12-20 parts of angelica sinensis, 10-18 parts of rhizoma atractylodis, 10-22 parts of mangnolia officinalis, 12-20 parts of agilawood, 10-20 parts of elecampane, 12-20 parts of immature bitter orange, 10-17 parts of rhizoma cyperi, 10-20 parts of myrrh, 15-22 parts of hawthorn, 5-20 parts of malt, 10-20 parts of kamuning, 12-20 parts of borneol, 10-18 parts of camphor, 10-17 parts ofpurple perilla, 13-20 parts of earthworm, 12-20 parts of ligusticum wallichii, 10-23 parts of frankincense, 15-22 parts of semen brassicae, 12-22 parts of safflower carthamus, 15-21 parts of hematoxylon, 15-25 parts of rohdea japonica, 11-20 parts of Japanese beauty-berry, 15-25 parts of pubescent holly root, 10-18 parts of salviae miltiorrhizae, 13-20 parts of garden balsam seed, 15-25 parts of rhizoma sparganii and the like. The traditional Chinese medicine composition disclosed by the invention is capable of promoting blood circulation to remove blood stasis, relieving swelling and pain, dispelling wind and eliminating dampness, and soothing channels and activating collaterals; the medicines are combined by adopting a traditional Chinese medicine hot compress method; and the traditionalChinese medicine composition has a good curative effect on swelling and pain caused by arthritis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis and the like, and is safe to use, simple and convenient to take and lasting in efficacy.