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Chronic skin ulcer treating medicine for external application and preparation method of chronic skin ulcer treating medicine for external application

A technology for chronic skin ulcers and external application of medicines, applied in skin diseases, pharmaceutical formulations, medical preparations containing active ingredients, etc. Wound healing rate and onset speed, simple formula effect

Inactive Publication Date: 2016-11-23
北京市中医研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, debridement, dressing change, skin grafting, laser, hyperbaric oxygen and other methods are mainly used clinically for sores, but the clinical efficacy is not satisfactory, mainly manifested in the low rate of wound healing

Method used

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  • Chronic skin ulcer treating medicine for external application and preparation method of chronic skin ulcer treating medicine for external application
  • Chronic skin ulcer treating medicine for external application and preparation method of chronic skin ulcer treating medicine for external application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Grinding: According to astragalus 100g, cinnamon 30g, chuanxiong 30g, musk 1g, grind the four herbs into powder, and pass through a 100-mesh sieve.

[0031] Ethanol leaching: Extract the four-flavor medicinal powder twice, add 10 times the mass of 95% ethanol for the first time, and soak for half an hour. Use a flash extractor to flash extract 3 times (the time is 30 seconds, 15 seconds, and 15 seconds respectively), centrifuge, take the supernatant and pour it into a round bottom flask for recovery under reduced pressure. This is 1 solution. For the second time, add 8 times the mass of 95% ethanol, flash extract 3 times, centrifuge to get the supernatant, mix it with 1 liquid for recovery under reduced pressure, and vacuum dry.

[0032] The above-mentioned concentrated compound alcohol extract is dissolved in physiological saline, filtered and sterilized, and added to aseptic gelatin sponges of different sizes to prepare a disposable aseptic traditional Chinese medicin...

Embodiment 2

[0034] Grinding: 300g of astragalus, 100g of cinnamon, 100g of chuanxiong, 3g of musk, the four herbs are ground into powder, and sieved through a 100-mesh sieve.

[0035] Ethanol leaching: Extract the four-flavor medicinal powder twice, add 10 times the mass of 95% ethanol for the first time, and soak for half an hour. Use a flash extractor to flash extract 3 times (the time is 30 seconds, 15 seconds, and 15 seconds respectively), centrifuge, take the supernatant and pour it into a round bottom flask for recovery under reduced pressure. This is 1 solution. For the second time, add 8 times the mass of 95% ethanol, flash extract 3 times, centrifuge to get the supernatant, mix it with 1 liquid for recovery under reduced pressure, and vacuum dry.

[0036] The above-mentioned concentrated compound alcohol extract is dissolved in physiological saline, and added to aseptic gelatin sponges of different sizes after filter sterilization to prepare disposable aseptic traditional Chinese...

Embodiment 3

[0038] Grinding: According to astragalus 200g, cinnamon 30g, chuanxiong 60g, musk 2g, the four herbs are ground into powder, and passed through a 100-mesh sieve.

[0039] Ethanol leaching: Extract the four-flavor medicinal powder twice, add 10 times the mass of 95% ethanol for the first time, and soak for half an hour. Use a flash extractor to flash extract 3 times (the time is 30 seconds, 15 seconds, and 15 seconds respectively), centrifuge, take the supernatant and pour it into a round bottom flask for recovery under reduced pressure. This is 1 liquid. For the second time, add 8 times the mass of 95% ethanol, flash extract 3 times, centrifuge to get the supernatant, mix it with 1 liquid for recovery under reduced pressure, and vacuum dry.

[0040] The above-mentioned concentrated compound alcohol extract is dissolved in physiological saline, filtered and sterilized, and added to aseptic gelatin sponges of different sizes to prepare a disposable aseptic traditional Chinese me...

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Abstract

The invention provides a chronic skin ulcer treating medicine for external application and a preparation method of the chronic skin ulcer treating medicine for external application. The chronic skin ulcer treating medicine for external application is mainly prepared from, by weight, 100-300 parts of Radix Astragali, 30-100 parts of Cortex Cinnamomi, 30-100 parts of Rhizoma Ligustici Wallichii and 1-3 parts of musk. The medicine for external application is high in wound healing rate of chronic skin ulcer and has advantages of formulation simplicity, directness to lesions, freeness of first pass effect and the like.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an externally applied medicine for treating chronic skin ulcers and a preparation method thereof. Background technique [0002] Chronic skin ulcer is a common complication of diabetes, peripheral vascular disease, microbial infection, and radiotherapy. At present, debridement, dressing change, skin grafting, laser, hyperbaric oxygen and other methods are mainly used clinically for sores, but the clinical efficacy is not satisfactory, mainly manifested in the low rate of wound healing. Contents of the invention [0003] The object of the present invention is to provide an external application medicine for treating chronic skin ulcers. The external application medicine has a high wound healing rate for chronic skin ulcers, and has the advantages of simple formula, direct focus, no first-pass effect and the like. [0004] Another object of the present invent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P17/02A61K35/55
CPCA61K9/0014A61K35/55A61K36/236A61K36/324A61K36/481A61K36/537A61K36/54A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 李萍何秀娟赵京霞梁雅慧张颖马秋洁戴淼可万家兴
Owner 北京市中医研究所
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