56 results about "Chronic skin ulcers" patented technology

Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over- expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.

The invention provides an Acetobacter xylinum Y05 strain and a method for preparing nanometer cellulose skin tissue repairing material with the same. The preparation method comprises the following steps that: Acetobacter xylinum Y05 (CCTCC M 207163) preserved on an inclined plane is made into a shake-flask seed and cultivated statically to obtain a nanometer cellulose membrane; and the well-cultivated membrane is separated, purified and then compounded with natural polysaccharide (chitosan, etc.) and protein (collagen, silk fibroin, etc.), so as to prepare the repairing material. The nanometer repairing material has good biocompatibility, flexibility and strength which are similar to human skin, as well as good plasticity and elasticity, can be suitable for various irregular wound surfaces, can keep moisture for a long time, and can be used as a skin substitute and medical dressings for burns, chronic skin ulcers and other skin injuries or defects in clinical practice.

Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fibroblasts (3) from a skin biopsy (5). Clotting is obtained by adding calcium. This artificial dermis (1) provides for the rapid growth of the keratinocytes (6) seeded on its surface to build an artificial skin (7) which can easily be transplanted. Large areas of artificial dermis (1) are obtained from a small skin biopsy (5) and minimal quantities of plasma with platelets (2), which being enriched with cytokines and platelet growth factors, strengthens the proliferation of the cells seeded, both inside and on the surface. The artificial skin (7) obtained can be used to treat major burn treatments, chronic skin ulcers, etc., or be used, by employing genetically altered cells, as a vehicle for gene therapy.

The invention discloses a fibroin porous material loading insulin / fibroin microspheres and a preparation method thereof, belonging to the technical field of biomedical materials. The fibroin microspheres loading insulin are prepared by using a coaxial high voltage electrostatic technique and a freeze drying method and the porous material loading insulin / fibroin microspheres is prepared by using a layer-by-layer assembly and freeze drying method. The porosity of the porous material is 70-90% and the bore diameter is 50-200 microns. The microspheres are uniformly distributed inside the porous material and are firmly combined with the material. Insulin loaded in the material can be sustainably and slowly released for over 20 days and the releasing rate is over 94%. Insulin released from the fibroin porous material loading insulin / fibroin microspheres prepared by the invention has bioactivity and can stimulate epidermis cells and endothelial cells to migrate so as to increase the wound healing speed and improve the wound healing quality. The fibroin porous material loading insulin / fibroin microspheres disclosed by the invention provides wound dressing with a good performance for treating such defects of skins as wounds and burn and chronic ulcer of skins.

Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.

The invention provides a preparation method of a gel containing a fibroblast growth factor-1 modified body and an application thereof for treating chronic skin ulcer caused by diabetic foot. The gel disclosed by the invention comprises the following components: 20000-80000 IU of recombinant human fibroblast growth factor-1 modified body (FGF-1135) protein, 10 pg to 40 mu g of low molecular weight heparin sodium, 0.2-1.0 g of glycerol, 50-150 mg of a protein protectant, and 0.03-0.05g of a gel substrate, wherein the pH value is adjusted; and water for injection is added to be 10 ml. Compared with the original sequence, the fibroblast growth factor-1 modified body used in the invention is more steady; after being prepared into the gel, the fibroblast growth factor-1 modified body is more convenient for clinical application; the better stability and slow-release effects can be achieved; the bioavailability of protein is increased; the gel is more beneficial to treating diabetic foot; and the gel can be also used for treating burning, scalding and other chronic and refractory ulcers.

The invention relates to a regeneration material of artificial dermis substitution and a preparation method thereof. In the regeneration material of a dermis substitution for tissue engineering skin for loading rhGM-CSF, the regeneration material is formed by a heparinizing collagen-chitosan bracket loading the rhGM-CSF solution. The invention further discloses a preparation method of the regeneration material. The invention provides an artificial dermis substitution with good performance for curing the whole skin coloboma of trauma, burning, chronic skin ulcer, thereby being capable of remarkably quickening the vascularization process of the regeneration material of artificial dermis substitution, decreasing the infection risk, promoting the healing of the surface of a wound and reducing the hyperplasia of scar, and thus easing the pain of patients. The invention can be widely applied for the aspects of trauma, burning, surgery reshaping, and the like. The preparing method is simple, the source of the material is wide, the production efficiency is high, and the invention is suitable for industrial production.

The invention relates to an externally applied preparation for treating skin wound, in particular to an externally applied preparation for treating chronic skin ulcer, which is characterized in that it comprises the effective components in weight as follows: insulin 500-5000u / 1000g, epidermal growth factor 0.001-0.01g / 1000g, antibacterials 5-20g / 1000g, others are adjuvant. It can treat a variety of infectious and protracted skin ulcer safely and effectively.

Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over-expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.

The present invention relates to a hygiene product or a pharmaceutical composition in the form of a gel or dressing, for topical application to the skin or mucosa including glycerol, at least one poly(meth)acrylate polymer, at least one polyethylene glycol having a molecular weight of less than 1000 g / mol, octanediol and water.The composition or dressing can be used for healing treatment of chronic dermal ulcers, healing and soothing treatment of eczema and psoriatic conditions, healing treatment of anal fissures, treatment of mouth injuries, resorption and healing of labial herpes (cold sore) and treatment of dermatitis.The hygiene product can be a shaving or aftershave product for sensitive or hypersensitive skin, a nasal decongestant product or a product for ear hygiene.

Disclosed is a method of promoting healing of a chronic dermal ulcer, such as a diabetic ulcer, in a subject. The method comprises administering to the subject a combination one or more agonists of the non-proteolytically activated thrombin receptor and one or more angiogenic growth factors.

The invention discloses a medicinal composition for treating chronic skin ulcer. The medicinal composition is prepared from the following raw material medicines in percentage by weight: 2 to 15 percent of root of red-rooted salvia, 2 to 15 percent of rheum officinale, 2 to 15 percent of purple gromwell, 2 to 15 percent of Szechuan lovage rhizome, 2 to 15 percent of baical skullcap root, 2 to 15 percent of pseudo-ginseng, 2 to 15 percent of dragon's blood, 2 to 15 percent of frankincense, 2 to 15 percent of myrrh and 2 to 15 percent of goldthread. The preparation method is characterized by comprising the following steps of: frying the root of red-rooted salvia, the goldthread, the rheum officinale, the purple gromwell, the Szechuan lovage rhizome and the baical skullcap root in high temperature sesame oil until the medicines are yellow, grinding the pseudo-ginseng, the dragon's blood, the frankincense and the myrrh into powder, adding the powder, heating the obtained liquid medicine, putting the purple gromwell, frying for several minutes, stirring, filtering and packaging. The invention has the advantages that: 1, the medicinal composition has a high flesh-engendering effect, promotes the wound surface of ulcer to be repaired, promotes blood circulation and ensures that the skin surface is smooth after the wound surface is repaired; 2, the medicinal composition has an obvious pain relieving effect, and a patient feels cool and comfortable at the local of the wound surface; 3, the medicinal composition is safe and does not have any irritability or related toxic and side effects; and 4, the medicinal composition is economic and the treatment cost is low.

The invention discloses a method for preparing a skin regeneration material loaded with bioactive glass particles. The method specifically comprises the steps of 1, preparing glass powder; 2, preparing silk fibroin concentrated aqueous solution; and 3, mixing and evenly stirring the glass powder, polyvinyl alcohol, chitosan solution and the silk fibroin solution, conducting vacuum defoamation to obtain blended solution, obtaining a four-dimensional porous support with the freezing-drying method, cross-linking the four-dimensional porous support with glutaraldehyde solution, and conducting freeze drying again after repeated cleaning to obtain the finished product. The skin regeneration material is a high-performance skin substitute for treatment of serious skin defects like wounds and burns as well as chronic ulcers of skin, and can remarkably promote healing of a wound surface and reduce scar hyperplasia, so as to relieve pain for patients. The skin regeneration material can be widely applied to wounds, burns, plastic surgery and other aspects. The preparing method is simple, raw materials are widely available, production efficiency is high, and the preparing method is suitable for industrialized production.

The invention relates to an externally-applied traditional Chinese medicine preparation for accelerating healing of chronic skin ulcer wounds and a preparation method thereof. According to the preparation, root of angelica sinensis(oliv.)diels, frankincense, commiphora myrrha engl.[c.molmol engl.], daemonorops draco blume., flower of carthamus tinctorius l. and dried body of eupolyphaga sinensis walker are used as monarch drugs capable of promoting blood circulation, removing obstruction in collaterals and relieving pain; unprocessed rehmannia root, root of paeonia veitchii lynch, root of scrophularia ningpoensis hemsl., root of rheum palmatum L. and root of lithospermum erythrorhizon sieb.et zucc. are used as ministerial drugs capable of cooling blood, relieving pain, detoxifying, and reinforcing the pain relieving effects of the monarch drugs; root of sophora flavescens ait. and cortex of phellodendron chinense Schneid. are capable of clearing heat and drying dampness; root of angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f., root of notopterygium incisum ting ex h.t.chang and angelica pubescens Maxim.f.biserrata Shan et Yuan have the effects of dispelling wind and eliminating dampness; the root of sophora flavescens ait., the cortex of phellodendron chinense schneid., the root of angelica dahurica(Fisch.ex Hoffm.) Benth.et Hook.f., the root ofnotopterygium incisum tingex h.t.chang and the root of angelica pubescens Maxim.f.biserrata Shan et Yuan can cooperate with one another to remove damp heat toxin and fire toxin formed when circulation of qi and blood is unsmooth and qi and blood overflow outside veins due to stasis and blockage of blood vessels; the damp heat toxin and fire toxin are accumulated subcutaneously to form lumps; tuber of ampelopsis japonica(Thunb.)Makino, momordica cochinchinensis(Lour.)Spreng. and forsythia suspensa(thunb.)vahl are used to assist in clearing heat, removing stasis and diminishing swelling; the sophora flavescens ait., thephellodendron chinense schneid., the angelica dahurica(fisch.ex hoffm.)benth.et hook.f., the notopterygium incisum ting ex h.t.chang, angelica pubescens maxim.f.biserrata shan et yuan, the ampelopsisjaponica(thunb.)makino, seed of momordica cochinchinensis(Lour.)Spreng. and fruit of forsythia suspensa(Thunb.)Vahl are jointly used as adjuvant drugs; cinnamomum cassia presl, tuber of lindera aggregata(Sims)Kosterm. and borneol are capable of inducing menstruation to relieve menalgia and reinforcing the pain relieving effects of the monarch drugs; bletilla striata(Thunb.)Reichb.f. is capable ofdiminishing swelling and promoting granulation; the cinnamomum cassia presl, the lindera aggregata(sims)kosterm., the borneol and the rhizome of bletilla striata(Thunb.)Reichb.f. are jointly used as envoy drugs. Through treatment and follow-up on multiple patients with diabetic foot gangrene and decubital ulcer, the total effective rate is 100%.

The present invention relates to a method for diagnosing and treating chronic skin ulcer by using a set pair analysis-based yin-yang balance equation and a system. The method includes the following steps that: the clinical symptoms of a patient are compared with a chronic skin ulcer yin-yang syndrome differentiation reference indication table, so that the chronic skin ulcer yin-yang syndrome differentiation quantification table of the patient is obtained; the yin-yang balance equation of the patient is obtained according to the quantification table; and corresponding traditional Chinese medicines are selected according to quantification symbols on meridians in the yin-yang balance equation so as to cure the chronic skin ulcer. The system comprises a clinical symptom recording module, a patient chronic skin ulcer clinical yin-yang syndrome differentiation quantization table generating module, a medicine recording module, a medication guiding module and a phased treatment efficacy evaluation feedback module. The invention also relates to a method for judging the stage of a chronic skin ulcer disease and time required for curing the disease on the basis of a set pair analysis-based yin-yang balance equation, and a method for judging the treatment level of the traditional Chinese medicine for chronic skin ulcer on the basis of a set pair analysis-based yin-yang balance equation. With the methods of the invention adopted, the modernization of the syndrome differentiation and treatment theories in the traditional Chinese medicine for the chronic skin ulcer can be benefitted.

The invention belongs to an externally used heavy-metal-free ointment for treating skin wounds and a preparation method thereof. The ointment is prepared by using the following raw materials by weight: 20-35g of golden thread, 10-25g of baical skullcap root, 10-25g of amur cork-tree, 20-42g of danshen root, 10-20g of Hibiscus mutabilis leaf, 15-35g of giant knotweed rhizome, 15-38g of garden burnet root, 15-35g of common bletilla rubber, 10-25g of cape jasmine fruit, 10-25g of gromwell root, 10-25g of suberect spatholobus stem, 5-15g of borneol, 10-30g of calamine, 10-25g of beeswax, 50-100g of Vaseline and 600-1000g of vegetable oil. The externally used ointment prepared in the application does not contain heavy metal elements and can treat various new and old open skin wounds such as incised wounds, blunt force injuries, accidental injuries, burns due to hot liquid or fire and ecthyma, which are called as various surgical injuries, accidental wounds, infected wounds, chronic skin ulcers, pressure sores and the like, and the wound healing time is short.

The invention discloses a lotion for treating chronic skin ulcer caused by damp-heat and toxicity accumulation and a preparation method of the lotion. The lotion comprises the following raw medicinal materials: borneol, dragon bones, calcined gypsum, calamine, dragon blood, calomel, hydrargyri oxydum rubrum, hen egg membranes, hen egg yolk, fructus cannabis, rhizoma bletillae, olibanum, myrrh, coptis chinensis, diverse wormwood herbs, safflowers, radix saposhnikoviae, white honey, rhizoma atractylodis macrocephalae, Chinese yams, oysters, talc, Chinese galls, honeysuckles, fructus forsythiae, dandelion, mint, agastache rugosus and raw liquorice. The lotion is based on the principles of drawing out toxins and promoting granulation, also has the effects of astringing sores and protecting membranes, clearing away heat and toxic materials, nourishing muscles and protecting skins as well as removing blood stasis for promoting tissue regeneration, and is mainly used for treating chronic skin ulcer caused by damp-heat and toxicity accumulation; the preparation method is simple and convenient; the lotion is convenient to dose, easy to prepare, low in cost, exact in curative effect, specific in drug property as well as rapid and thorough in treating special diseases; and chronic skin ulcer caused by damp-heat and toxicity accumulation does not easily recur after being healed.

The invention relates to application of astragaloside in preparation of drugs for promoting epithelization in wound healing. The astragaloside can correct the inhibition effect on the proliferation and migration of keratinocyte under the condition of imitating and activating a classical Wnt signaling channel with lithium chloride, thus the astragaloside has promotion action on the epithelization stage in wound healing process and can be used for preparation of the drugs for treating chronic skin ulcer or other skin wound surfaces. The invention has the advantages that: the new application of the astragaloside in pharmacy is developed, and a new application field is developed; the astragaloside can promote the proliferation and migration of keratinocyte, namely accelerate the epithelization course in wound healing process, therefore, the astragaloside has the effect of promoting wound healing and an important clinical basis is provided for prevention and treatment of chronic skin ulcer; and the astragaloside has wide raw material sources, low price, s and broad industrial prospects, and the preparation process of the astragaloside is simple. The astragaloside is suitable for wide popularization and use.

The invention discloses a traditional Chinese medicinal ointment for treating burns and scalds. The ointment comprises the following components in parts by weight: 25-40 parts of rhodiola rosea, 5-10 parts of radix tetrastigme, 10-20 parts of sanguisorba officinalis, 10-20 parts of polygonum cuspidatum, 5-10 parts of zanthoxylum nitidum dc, 5-10 parts of centipede, 3-10 parts of borneol, 30-60 parts of yellow wax, and 300-500 parts of sesame oil. The invention also discloses a preparation method of the traditional Chinese medicinal ointment for treating burns and scalds. The formula of the traditional Chinese medicinal ointment is scientific in preparation method, low in cost, simple in method and easy to operate, has the effects of clearing heat and removing toxicity, activating blood circulation to remove stasis, eliminating necrotic tissues and promoting granulation, relieving pain and resisting inflammation, and promoting metabolism and body tissue in-situ regeneration, has unique treatment effects on first-degree, second-degree and third-degree burns and scalds, electrical injury and chemical burns, and also has better curative effects on chilblain, bedsore and chronic skin ulcer.

This invention relates to methods for treating chronic dermal ulcers using hyperbaric treatment in combination with progenitor cells and chemokine homing factors. Specifically, the invention relates to treatment of chronic wounds resulting from diabetes mellitus using compositions comprising EPC and SDF-1A, under hyperbaric condition to accelerate wound healing.

The invention discloses tea polyphenol film agent and the preparation method thereof which are used for the treatment of chronic ulcer of skin. Tea polyphenol and vitamin B12are taken as the main component, and the film agent is produced by adding auxiliary materials of film forming material and plasticizer, etc. The preparation method comprises the following steps: the film forming material is soaked in water, heated and dissolved in a water bath at 30 to 80 DEG C, and filtered, the tea polyphenol, the vitamin B12, and the plasticizer are added into the filtrate in proportion, uniform mixing, air bubble removing, film coating, drying and parting cut are performed, and then the tea polyphenol film agent product is obtained. The film agent of the invention can be effectively used to treat diabetes foot ulcer, hansens disease ulcer and other chronic ulcers of skin, and also used to treat skin ulcer caused by burn and scald, can quicken the healing of ulcers, increase the scarfskin complete coverage percentage, the ulcers are uneasy to recur, the film agent is safe and non-toxic, and the cost is low.

The invention provides a preparation method of a gel containing a fibroblast growth factor-1 modified body and an application thereof for treating chronic skin ulcer caused by diabetic foot. The gel disclosed by the invention comprises the following components: 20000-80000 IU of recombinant human fibroblast growth factor-1 modified body (FGF-1135) protein, 10 pg to 40 mu g of low molecular weight heparin sodium, 0.2-1.0 g of glycerol, 50-150 mg of a protein protectant, and 0.03-0.05g of a gel substrate, wherein the pH value is adjusted; and water for injection is added to be 10 ml. Compared with the original sequence, the fibroblast growth factor-1 modified body used in the invention is more steady; after being prepared into the gel, the fibroblast growth factor-1 modified body is more convenient for clinical application; the better stability and slow-release effects can be achieved; the bioavailability of protein is increased; the gel is more beneficial to treating diabetic foot; and the gel can be also used for treating burning, scalding and other chronic and refractory ulcers.

The invention discloses a wound repair material for cell suspension transplantation and a preparation method of a wound repair material. The wound repair material comprises a collagen base layer prepared from 3D porous collagen sponge by tabletting treatment, the collagen sponge is prepared from a collagen-based compound solution by crosslinking treatment, the collagen-based compound solution comprises type I collagen protein and a composite, and the composite is elastin or anion mucopolysaccharide. The collagen base layer in the wound repair material for cell suspension transplantation can beused as a support stent for epidermal cell adhesion, proliferation and migration to provide a proper microenvironment for wound healing, the wound repair material can rapidly close donor sites, shallow burn wounds of large-area burn patients and shallow wounds caused by chronic skin ulcer by combining autologous epidermis cell suspension and has better application prospects in cell suspension transplantation.

The invention provides a chronic skin ulcer treating medicine for external application and a preparation method of the chronic skin ulcer treating medicine for external application. The chronic skin ulcer treating medicine for external application is mainly prepared from, by weight, 100-300 parts of Radix Astragali, 30-100 parts of Cortex Cinnamomi, 30-100 parts of Rhizoma Ligustici Wallichii and 1-3 parts of musk. The medicine for external application is high in wound healing rate of chronic skin ulcer and has advantages of formulation simplicity, directness to lesions, freeness of first pass effect and the like.

The invention relates to a laminin wound protective film which takes animal plasma laminin as a main component and consists of a stroke-physiological saline solution and a pharmaceutical adjuvant. The laminin wound protective film comprises the following specific components in parts by weight: 1-30 parts of an animal plasma laminin micro-capsule, 0.1-30 parts of a film-forming substrate, 1-10 parts of a moisturizing agent and the rest part of stroke-physiological saline solution. The animal plasma laminin micro-capsule takes a laminin solution dissolved into water as a capsule core material and is coated with a capsule material; the film-forming substrate is one or more of polyvinyl alcohol, carbomer, sodium alginate and calcium alginate. The laminin wound protective film provided by the invention has the advantage that the laminin is made into the micro-capsule, so that while the biological activity of the micro-capsule is maintained, the shelf life is prolonged. The laminin wound protective film provided by the invention can be made into a water agent form or a gel form and is simple in preparation process and suitable for large-scale production. The laminin wound protective film provided by the invention can be directly sprayed and coated onto wounds of patients with burn, trauma, diabetic foot rot, ulcers, other chronic skin ulcers and the like and is convenient to use and good in treatment effect.

This invention relates to methods for treating chronic dermal ulcers using hyperbaric treatment in combination with progenitor cells and chemokine homing factors. Specifically, the invention relates to treatment of chronic wounds resulting from diabetes mellitus using compositions comprising EPC and SDF-1A, under hyperbaric condition to accelerate wound healing.

The invention relates to a method and a system for treating a chronic skin ulcer disease on the basis of a chronic skin ulcer disease differentiation correlate model. The method comprises the following steps: (1) taking clinical diagnosis result and a degree level thereof as specific exhibition or supplementation on the right side of the correlate model; (2) according to the signs of a patient, using a differentiation and treatment theory and experiment for differentiation, and supplementing pathogenesis discussion on the right side of the correlate model; and (3) dosing according to pathogenesis, internal organs and discriminated chain prescription of adjacent internal organs or related internal organs, wherein the differentiation correlate model is that (spleen, stomach)+(liver, gallbladder)i+(heart, small intestines)j+(lungs, large intestines)k+(kidneys, bladder)l=f(e,-e)skin. The system comprises a clinical diagnosis recording module, a chronic skin ulcer disease correlate model generating module, a medicine recording module, a medication guiding module and a periodic treatment effect evaluation and feedback module. The method is conducive to quantificational research of traditional Chinese medicine syndrome differentiation and treatment theory, so that the clinical effect is improved.