13 results about "Ulcer disease" patented technology

The invention discloses a symmetric nucleoside microneedle patch loaded with polymer vesicles as well as a preparation method and application of the symmetric nucleoside microneedle patch. The symmetric nucleoside microneedle patch loaded with the polymer vesicles comprises a guanosine-quadruplex hydrogel microneedle tip doped with drug-loading polymer vesicles, the raw material of the drug-loaded polymer vesicle comprises a polycaprolactone-polyglutamic acid copolymer; the guanosine-quadruplex hydrogel is prepared from the following raw materials: guanosine and KB (OH) 4. The microneedle patch is constructed on the basis of dynamic covalent bond and non-covalent interaction, has a sharp tip array capable of penetrating the epithelium and the lower layer of a mucous membrane, can efficiently deliver a drug to a canker lesion part by bypassing a mucous membrane barrier, can be controllably broken under a high ROS condition of an inflammation microenvironment, has the characteristics of high drug delivery efficiency and high accuracy, and can be used for preparing a medicine for treating the canker lesion part. The effect of effectively improving chemotherapy-induced oral ulceration can be achieved by reducing inflammatory response, relieving pain feeling and inhibiting pain sensitization.

The application discloses a kind of auxiliary diabetic foot ulcer grading wound image analysis method, it is related to medical image analysis technical field, can solve how to based on single frame optical image automatically, accurately distinguish the problem of solid-state necrotic tissue and liquid pus exudate with visual feature highly similar in diabetic foot ulcer wound, including: determining ulcer lesion area in input image, and determine lesion equivalent diameter;Determine the first point set that all tissue sample points to be classified in ulcer lesion area constitute, and the second point set that all potential convergence positions in ulcer lesion area constitute;According to lesion equivalent diameter, first point set and second point set, construct total cost matrix;Total cost matrix is solved using preset matching algorithm, each point in first point set is classified as liquid attribute point or solid attribute point;According to the number of being classified as liquid attribute point and first quantity determine liquid component proportion, compare with preset threshold value, output diabetic foot ulcer grading result.

The application relates to the medical technical field, in particular to application of zidovudine in preparation of a medicine for preventing and / or treating alcoholic gastric ulcer, and experiment results show that the zidovudine has a remarkable curative effect on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, and restore animal body weight, and has a good clinical application prospect.

The invention discloses an asiatic acid saponin compound and medical application thereof. The asiatic acid saponin compound comprises a compound with a structural formula as shown in a formula (I), and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula (I) has anti-inflammatory and anti-ulcer activity, so that the compound can be used for preparing medicines for preventing or treating inflammatory diseases or ulcerative diseases.

Recombinant blood group antigen-binding adhesin (BabA) can be used in a composition to raise humoral immune response i.e. antibodies, that target conserved structural epitopes in the fucosylated blood group antigen Lewis b (Leb) antigen binding domain in the blood group antigen-binding adhesin (BabA). Such broadly Leb-blocking antibodies can reduce the gastric mucosal attachment of Helicobacter pylori (H. pylori) to human gastric mucosa. This approach can be used for preventing and / or alleviating gastric disease in a subject diagnosed with H. pylori infection, said gastric disease chosen from gastroesophageal reflux disease, chronic active gastritis, peptic ulcer diseases, gastric ulcer disease, gastric cancer gastritis and gastric cancer, in particular gastric cancer. It also becomes possible to identify subjects that carry BabA positive H. pylori infections and subjects that are at risk of developing severe gastric disease, such as peptic ulcer diseases, gastric ulcer disease, gastritis with metaplasia and gastric cancer.

The application relates to the medical technical field, in particular to application of 6-mercapto guanine in preparation of a medicine for preventing and / or treating alcoholic gastric ulcer, experimental results show that the 6-mercapto guanine has remarkable curative effect on peptic ulcer disease and inflammatory bowel disease, can effectively improve mucosal integrity, promote tissue morphology improvement, restore animal body weight, and has a good clinical application prospect.

The application relates to the medical imaging technical field, in particular to a biopsy range positioning method and device for a gastric ulcer image, obtaining a gastric ulcer image of a patient to be detected, preprocessing the gastric ulcer image to obtain a gastric ulcer optimization image of the gastric ulcer image; inputting the gastric ulcer optimization image into an ulcer lesion detection model and a background target detection model respectively, outputting a lesion segmentation image of the gastric ulcer optimization image and a background target; fusing the lesion segmentation image and the background target, and outputting an ulcer biopsy range positioning and a biopsy sequence of the patient to be detected. The application realizes lesion segmentation of a gastric ulcer, thereby obtaining a gastric ulcer biopsy range, assisting a doctor in positioning biopsy, constructing a coordinate system by taking the center points of a large bend and a mirror body and the center point of a gastric ulcer as the coordinate system, combining logic, judging the biopsy sequence, and efficiently improving the gastroscopy detection efficiency.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and application and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following components in parts by weight: 3-35 parts of garden burnet, 2-22 parts of pawpaw, 2-18 parts of radix curcumae, 1-26 parts of radix stephaniae tetrandrae, 2-16 parts of rhizoma atractylodis, 3-13 parts of rhizoma bletillae, 5-23 parts of rhizoma corydalis, 2-20 parts of cortex phellodendri, 1-12 parts of borneol, 25-60 parts of calcined gypsum, 30-70 parts of calamine, 3-18 parts of frankincense, 2-15 parts of myrrh and 2-17 parts of dragon's blood. The traditional Chinese medicine is prepared from the following components in parts by weight: 2-16 parts of hematoxylon, 3-13 parts of rhizoma sparganii, 3-15 parts of notopterygium root, 2-16 parts of pseudo-ginseng and 85-150 parts of sesame oil. The traditional Chinese medicine composition disclosed by the invention is suitable for various long-term non-healing wounds with unknown reasons, such as long-term non-healing wounds caused by postoperative, infection, burn and diabetic foot, and sore and ulcer diseases such as chilblain, ecthyma, bedsore and the like, and has a remarkable curative effect.

The invention relates to the technical field of medical imaging, in particular to a biopsy range positioning method and device for a gastric ulcer image, and the method comprises the steps: obtaining a gastric ulcer image of a to-be-detected patient, carrying out the preprocessing of the gastric ulcer image, and obtaining a gastric ulcer optimized image of the gastric ulcer image; respectively inputting the stomach ulcer optimized image into an ulcer focus detection model and a background target detection model, and outputting a focus segmentation image and a background target of the stomach ulcer optimized image; and fusing the focus segmentation image and the background target, and outputting the ulcer biopsy range positioning and biopsy sequence of the patient to be detected. According to the invention, gastric ulcer focus segmentation is realized, so that a gastric ulcer biopsy range is obtained, and doctors are assisted in biopsy positioning; a coordinate system is constructed through the big bend, the center point of the endoscope body and the center point of the gastric ulcer, the biopsy sequence is judged in combination with logic, and the gastroscope detection efficiency is efficiently improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating cattle Tze Huang disease, which is prepared from semen lepidii, semen plantaginis, radix stephaniae tetrandrae and junci medulla according to the weight ratio of 1: 1: 1: 1. The traditional Chinese medicinal materials are adopted to form the formula, time, money and labor are saved, stress generated by cattle during injection can be effectively reduced, operation is easy, meanwhile, the prepared formula can be directly used externally, and therefore bacterial infection or serositis and the like possibly caused by injection can be reduced; meanwhile, when the formula is prepared, the formula is divided into two different groups, different treatments are respectively carried out, and then final mixing treatment is carried out, so that the traditional simultaneous crushing and mixing process of multiple materials is abandoned, the mixing effect of each group of formula can be improved, and the product quality can be improved; and the final particle uniformity and fullness of the product can be improved, and the external use effect is improved by virtue of the lubricating and medicine dissolving effects of the vegetable oil.

This embodiment provides a method and system for assessing the risk of diabetic foot ulcers based on visual nerves. The method includes: acquiring phosphorescent images of the patient's foot ulcer, images of the ulcer wound, and sensor feature data; processing the phosphorescent images based on a phosphorescent sub-network model to obtain an oxygen-phosphorescence response feature vector; processing the ulcer wound images based on a wound sub-network model to obtain an ulcer pathological feature vector; extracting physiological parameters from the sensor feature data based on a sensor sub-network model to obtain a physiological feature vector; and weightedly concatenating and fusing the oxygen-phosphorescence response feature vector, ulcer pathological feature vector, and physiological feature vector based on a fusion sub-network model to obtain a fused feature vector. The fused feature vector is then used for recognition operations to obtain a recognition result, the value of which indicates the patient's foot ulcer risk assessment level. This application achieves effective and accurate assessment of the condition of foot ulcer wounds in diabetic patients.

This disclosure provides methods for the treatment of peptic ulcer disease, comprising administering an effective amount of a formulation comprising an HIV protease inhibitor. The HIV protease inhibitor may comprise amprenavir or its prodrug fosamprenavir, darunavir, ritonavir, saquinavir, or a combination thereof. The formulation may also include a bioadhesive polymer, hydrogel, and / or biocompatible gel.

The invention provides an enema nano suspension system for treating ulcerative colitis, which is prepared by taking indigo blue and indirubin as active components, adding a space stabilizer and a potential stabilizer and adopting a wet medium grinding method. The invention also provides an enema nano-foam system for treating ulcerative colitis. The enema nano-foam system comprises the drug-containing foam base liquid and the propellant. Aiming at the problems of poor solubility and permeability of indigo blue and indirubin, auxiliary materials are combined with a ball milling technology, and indigo blue and indirubin are subjected to surface modification and nanocrystallization, so that the solubility and permeability of indigo blue and indirubin are improved, the absorption of inflammatory cells to drugs is enhanced, and the bioavailability of indigo blue and indirubin is improved. The problems that conventional dosage forms such as traditional Chinese medicine rectal administration enema liquid and suppositories are prone to leakage, strong in foreign body sensation, limited in medicine distribution area and difficult to reach deeper ulcer lesions in intestines are solved, and the vacancy that at present, no convenient and effective enema treatment is available for ulcerative colitis is made up.