The present application relates to a kind of
combination drug composition for preventing or treating diffuse large B-
cell lymphoma and its application, the
active component of the
combination drug composition is composed of first
active component and second
active component;The first active component is selected from selinexor or any one or at least two combinations of its pharmaceutically acceptable salt, isomer, solvate,
metabolite;The second active component is selected from
ritonavir or any one or at least two combinations of its pharmaceutically acceptable salt, isomer, solvate,
metabolite.The
combination drug composition has excellent
treatment effect of diffuse large B-
cell lymphoma, not only can reduce the dosage of selinexor, improve the safety of
drug, but also has more significant
inhibitory effect on diffuse large B-
cell lymphoma than using single selinexor.