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Compound tablet containing nemategravir and ritonavir

A technology of compound tablet and ritonavir, which is applied in the field of compound tablet containing Naimatevir and Ritonavir and its preparation, which can solve the problem of insufficient action time and the inability to guarantee the long-term maintenance of therapeutic concentration of Naimatevir To achieve the effect of reducing toxic and side effects, prolonging drug action time, and maintaining effective therapeutic concentration

Pending Publication Date: 2022-06-24
乐普制药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the problems that the existing preparations need to take multiple tablets at a time, and cannot guarantee the long-term maintenance of therapeutic concentration of nematevir, and the problem of insufficient action time

Method used

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  • Compound tablet containing nemategravir and ritonavir
  • Compound tablet containing nemategravir and ritonavir
  • Compound tablet containing nemategravir and ritonavir

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Experimental program
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Embodiment 1

[0036]

[0037]

[0038] Its preparation method is

[0039] (1) Preparation of nematevir microtablets:

[0040] The formula amount of nematevir and microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide and 1 / 2 formula amount of sodium stearyl fumarate are mixed uniformly by an equal amount incremental addition method;

[0041] The mixed material is dry granulated to obtain granules; additionally, 1 / 2 of the formula amount of sodium stearyl fumarate is added and mixed uniformly to obtain the total mixed granules;

[0042] A round die-cut tablet was selected to obtain nematevir microtablets.

[0043] Nematevir micro-tablet pack isolation layer: add purified water into the slurry tank, start stirring, then slowly add the formula amount of polyethylene glycol, and stir for more than 30 minutes until the solution is clear. Pour the naimatevir microtablets into the coating pot to coat the isolation layer. During the liquid spraying process, the tempera...

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Abstract

The invention discloses a compound tablet of nemategravir and ritonavir, the compound tablet is a coated chip, the drug delivery sequence is controlled by adopting an in-tablet technology, and through the combination of two layers of different drug release rates, a relatively ideal drug release rate can be obtained, an expected blood concentration can be achieved, and a stable and long-time effective concentration can be maintained; the toxic effect of the medicine is reduced, and adverse reactions such as gastric mucosa stimulation are avoided. The technology integrates the advantages of two single preparations. Medicine dissolution can be guaranteed, and meanwhile the stability of packaged medicine is guaranteed. Compared with the existing preparation which needs to take a plurality of tablets once and cannot ensure that the nemategravir can maintain the treatment concentration for a long time, the preparation disclosed by the invention can stably release medicine for a long time, greatly improves the in-vitro dissolution speed of the nemategravir and the ritonavir, solves the phenomena that the dissolution rate is low, the action time is short and a plurality of tablets need to be taken in the prior art, and can be used for preparing the nemategravir and the ritonavir. The medicine treatment effect is enhanced, the medicine treatment time is prolonged, and meanwhile the medicine taking compliance of a patient is improved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound tablet containing nematevir and ritonavir and a preparation method thereof. Background technique [0002] Coronaviruses are a large family of viruses known to cause colds as well as more serious diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). Novel coronavirus is a new strain of coronavirus. [0003] Coronaviruses (CoVs) belong to the Coronaviridae family of the order Nidovirus, and are enveloped single-stranded, positive-stranded RNA viruses, which are divided into three genera, α, β and γ. Coronavirus particles are spherical or irregular in shape, with an envelope and a size of 80-120nm. The 5' end of its genome has a cap structure, and then contains 6-10 open reading frames (Open reading frames, ORFs). The first reading frame occupying 2 / 3 of the genome encodes replicase, and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61K31/427A61K9/22A61P31/14
CPCA61K38/05A61K31/427A61K9/2095A61K9/209A61P31/14A61K2300/00
Inventor 潘裕生余佳培俞悦王海翔
Owner 乐普制药科技有限公司
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