12results about How to "Guaranteed curative effect" patented technology

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a sobering and hangover alleviating traditional Chinese medicine composition which comprises a component A and a component B, wherein the component A comprises a component a, a component b, a component c and a component d; the component B comprises a component e, a component f, a component g and a component h; in the component A, the component a is radix puerariae and an extract thereof; the component b is rhizoma polygonati and an extract thereof; the component c is poria cocos and an extract thereof; the component d is lily and an extract thereof; in the component B, the component e is radix ophiopogonis and an extract thereof; the component f is fructus lycii and an extract thereof; the component g is konjak and an extract thereof; the component h is orange peel and an extract thereof. The eight medicines are combined and can realize synergism, and excellent sobering and hangover alleviating effects can be obtained. The traditional Chinese medicine composition disclosed by the invention can have better sobering and hangover alleviating functions on the basis of the combined action of multiple mechanisms of metabolism acceleration, organ protection and system conditioning, and the components in the traditional Chinese medicine composition all belong to safe raw materials with homology of medicine and food.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to the application of a formula for nourishing vital energy and strengthening the body in reducing the toxicity of adjuvant chemotherapy after radical resection of non-small cell lung cancer. This invention discloses a formula for nourishing vital energy and strengthening the body, characterized in that it is composed of the following components by weight: 15-30 parts raw Astragalus membranaceus, 9-21 parts prepared Rehmannia glutinosa, 15-30 parts stir-fried Dioscorea opposita, 9-15 parts Atractylodes macrocephala, 9-15 parts Poria cocos, 15-30 parts raw Coix lacryma-jobi, 9-15 parts Ophiopogon japonicus, 9-15 parts Asparagus cochinchinensis, 15-30 parts Adenophora stricta, 9-15 parts Ligustrum lucidum, 9-15 parts Eclipta prostrata, 9-15 parts stir-fried germinated barley, 9-15 parts stir-fried malt, and 3-6 parts prepared Glycyrrhiza uralensis. This invention can restore vital energy, reverse postoperative weakness, build a foundation for chemotherapy tolerance to reduce toxic side effects, improve chemotherapy tolerance, reduce the risk of interruption to ensure efficacy, improve quality of life during chemotherapy, and help prolong postoperative survival.

This invention provides a fingerprint spectrum of Yishen Wufa Oral Liquid, its construction method, and its application, as well as a multi-index component detection method for Yishen Wufa Oral Liquid, relating to the field of pharmaceutical analysis and structural technology. The fingerprint spectrum of Yishen Wufa Oral Liquid constructed by this invention includes 20 characteristic peaks, including ferulic acid, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, astragaloside A, psoralen, isopsoralen, and emodin. The chromatographic peaks are abundant and attributed to the effective components of psoralen (roasted with black sesame seeds), angelica, poria cocos, wolfberry, fleeceflower root (processed with black bean wine), achyranthes bidentata, and astragalus complanatus. This provides a more comprehensive reflection of the overall chemical composition and quality of Yishen Wufa Oral Liquid, facilitating more effective guidance for feed addition and strict standardization of production operations. It also helps improve the safety and efficacy of Yishen Wufa Oral Liquid in clinical use, possessing high application value.

The application discloses a detection method of Baizhu San standard decoction fingerprint combined with liquid chromatography-mass spectrometry, the fingerprint and application thereof, and belongs to the field of traditional Chinese medicine quality standard research and application. Test sample solution and single control sample solution are injected into a high performance liquid chromatograph to obtain respective chromatograms; mass spectrometry analysis is conducted on the test sample solution to obtain mass spectrometry results; common peaks existing in the chromatogram of the test sample solution are taken as common peaks, chemical components in the Baizhu San standard decoction are identified in combination with the chromatogram of the single control sample solution and the mass spectrometry results of the test sample solution, and the Baizhu San standard decoction fingerprint is obtained. The fingerprint is constructed through liquid chromatography-mass spectrometry, 10 intersecting components are identified in combination with the mass spectrometry information of the control sample, so that the quality control of the Baizhu San standard decoction is realized, the method is simple, easy to operate, high in precision, good in stability and reproducibility, and can effectively solve the technical problem that the quality of the Baizhu San cannot be effectively evaluated.

The utility model aims to provide suspension high-shear dispersion preparation mixing equipment which comprises a dispersion machine, a stirring disc is arranged at the bottom of a main shaft, and the stirring disc comprises a second dispersion disc positioned at the bottom end of the main shaft, and a middle guide paddle and a first dispersion disc which are positioned above the second dispersion disc. The utility model relates to the technical field of mixing equipment, and adopts a multi-stirring impeller which combines a first dispersion disc and a second dispersion disc and is provided with a middle guide paddle between the first dispersion disc and the second dispersion disc, so that the stirring mode of a traditional single rectangular tooth dispersion impeller is changed; and the solution is rolled to the upper part by the second dispersion disc to be in contact with the first dispersion disc for secondary shearing. After secondary shearing, the particle size can be further refined, and the distribution is more uniform, so that the dissolution speed and bioavailability of the medicine are improved, and the curative effect of the medicine is ensured. Compared with the traditional equipment that the single-time stirring time is more than 15 minutes, the equipment disclosed by the utility model can obviously reduce the single-time stirring time.

The invention provides a construction method and a quality detection method of a characteristic spectrum of a traditional Chinese medicine composition, and the construction method of the characteristic spectrum comprises the following steps: taking a solution of a traditional Chinese medicine composition test sample and a solution of a reference substance, and carrying out high performance liquid chromatography detection to obtain the characteristic spectrum of the traditional Chinese medicine composition; wherein the traditional Chinese medicine composition comprises radix scutellariae, cortex mori radicis, fructus trichosanthis, semen armeniacae amarae, radix adenophorae, radix ophiopogonis, semen coicis, semen benincasae, fructus aurantii, radix curcumae, rhizoma imperatae, radix salviae miltiorrhizae, indigo naturalis and clam shells; the liquid chromatographic analysis conditions of the detection are as follows: octadecylsilane chemically bonded silica is used as a filler, acetonitrile is used as a mobile phase A, a phosphoric acid solution with the volume percentage of 0.09-0.11% is used as a mobile phase B, gradient elution is performed, the detection wavelength is 207-286nm, the column temperature is 25-35 DEG C, and the flow velocity is 0.9-1.1 mL / min. The specific chromatogram constructed by the invention can objectively evaluate the quality of a traditional Chinese medicine composition sample and improve the quality of the traditional Chinese medicine composition, so that the curative effect is ensured.

The invention belongs to the technical field of traditional Chinese medicine analysis, and particularly relates to a construction method and application of a specific chromatogram of an achyranthes aspera throat-clearing mixture. According to the invention, the spanning from single index control to overall quality evaluation is realized; the specific characteristic spectrum method for the achyranthes aspera throat-clearing mixture is established for the first time, and the limitation that only the content of a single component is measured in the prior art is broken through. By simultaneously monitoring the five key characteristic peaks of chlorogenic acid, caffeic acid, bergenin, geniposide and catechin and the consistency of the overall spectrum of the five key characteristic peaks, the basic material feeding condition and the matching stability of the monarch, minister, assistant and guide medicines in the preparation can be comprehensively reflected, so that the overall quality and the uniformity of the curative effect of the product are more scientifically guaranteed.

The utility model relates to the technical field of medical fixing devices, in particular to a head treatment fixator which comprises a combined fixing device and a fixing racket, and a lower jaw supporting piece and a front chest supporting fixator are arranged on the upper portion and the lower portion of the surface of one side of a fixator knob respectively. A telescopic rod piece is arranged on the surface of the top end of the tightening knob, a suction cup assembly is arranged on the surface of one end of the telescopic rod piece, and the lower jaw and the headrest part are supported to help a patient to fix the head and prevent the head from moving left and right and front and back; a simple device capable of pressurizing and fixing the treatment bat by screwing is configured, so that the treatment bat and the like are tightly attached to the treatment part of the head, dislocation of the head and the bat is further prevented, it is guaranteed that the bat stimulates the same site, the curative effect is guaranteed, the work of manually fixing the bat and the head by family members of a patient is liberated, and the overall using and fixing efficiency is improved.

The invention discloses a levofloxacin hapten, antigen and antibody as well as a preparation method and application thereof, and belongs to the technical field of small molecule immunodetection.A flexible spacer-(CH2) n-NH2 containing a terminal amino group is introduced to a nitrogen atom (namely a methyl connection site of methyl piperazine) at the tail end of a piperazine ring of a levofloxacin molecule, n is an integer of 2-8, and the flexible spacer-(CH2) n-NH2 is introduced into the nitrogen atom at the tail end of the piperazine ring of the levofloxacin molecule; therefore, a complete antigen with high immunogenicity and high specificity is constructed on the premise that a complete pharmacological structure of a quinolone mother nucleus is reserved, and a high-affinity antibody aiming at levofloxacin is obtained through induction.

The invention discloses application of RYK and a ligand-receptor signal axis inhibitor thereof in preparation of medicines for treating fatty liver diseases and pulmonary fibrosis, in the technical scheme provided by the invention, the RYK receptor is found and verified as a functional receptor of a secretory extracellular domain (G-ECD) of glycoprotein non-metastatic melanoma protein B for the first time; it is revealed that a G-ECD-RYK signal axis is a key mechanism for driving occurrence and development of metabolic dysfunction related fatty liver diseases / hepatitis (MASLD / MASH) and pulmonary fibrosis. According to the invention, the ligand G-ECD of the RYK is found, and the ligand-receptor signal axis of the RYK is determined to be a brand new drug target with high specificity.

The invention discloses a preparation method and application of a traditional Chinese medicine spray for treating asthma, and belongs to the technical field of traditional Chinese medicine preparations. The stability problem of the traditional Chinese medicine spray is systematically solved through the synergistic effect of alcohol precipitation impurity removal, volatile oil clathration, pH regulation and control and the ternary stabilizer. Pharmacodynamic studies show that the spray can remarkably reduce the inflammatory factor level of asthma model mice and prolong the incubation period of asthma inducing of guinea pigs, has the effect better than that of oral granules, takes effect quickly and is suitable for quick relief in the acute attack period of asthma.

The invention discloses a novel long-acting slow-release type fluralan solution as well as a preparation method and application of the novel long-acting slow-release type fluralan solution. The solution comprises the following components: 8-12% of fluralan and 55-70% of a composite slow-release carrier, and the composite slow-release carrier comprises chitosan subjected to denaturation treatment, polycaprolactone and pentaerythritol bis [bis (2-ethylhexyl) phosphate]. The preparation method comprises the steps of raw material pretreatment, microfluidic mixing, post-treatment and preparation. According to the invention, a long-acting slow-release system with uniform structure and stable performance is constructed by synergistically compounding the modified chitosan, the polycaprolactone and the pentaerythritol bis [bis (2-ethylhexyl) phosphate] in combination with a micro-fluidic precision process. According to the system, the release stability and the action durability of the medicine are remarkably improved, the burst release problem of a conventional preparation is effectively avoided, and long-acting protection of single administration is realized. Meanwhile, the product is excellent in storage stability, application tests show that the composition has a thorough control effect on red mites of laying hens, the administration frequency can be reduced, and the medication economy is effectively improved.