39results about How to "Guaranteed curative effect" patented technology

The invention discloses a quality control method of a traditional Chinese medicine preparation based on an IV-catfish orifice-freeing prescription, and relates to the technical field of analysis of traditional Chinese medicine preparations, and the quality control method comprises the following steps: carrying out microscopic identification on traditional Chinese medicine components in the IV-catfish orifice-freeing prescription, and determining a pharmacodynamic material basis. According to the quality control method for the traditional Chinese medicine preparation based on the IVV orifice-freeing prescription, various evaluation means such as a drug effect equivalent evaluation index, a stability test, a quality test and a clinical test are comprehensively applied, the consistency and reliability of the curative effect of the traditional Chinese medicine preparation can be remarkably improved, and the drug effect equivalent evaluation index is analyzed from the two factors of drug effect intensity and action time; the method ensures the equivalence of the medicinal component group and the original traditional Chinese medicine preparation, comprehensively detects the raw material medicines and the preparation, including characters, identification, inspection and content determination items, and ensures that the quality of each batch of samples meets the standard, so that the curative effect of the traditional Chinese medicine preparation is effectively guaranteed, and the efficacy of the traditional Chinese medicine preparation is improved.

The present invention belongs to the field of medical technology related to the extraction and application of natural drug components, discloses a white peony extract for treating hyperuricemia, a preparation method thereof and an application thereof, and provides a preparation method of a white peony extract for treating hyperuricemia, wherein the obtained white peony extract has a good therapeutic effect on a hyperuricemia animal model; mainly inhibiting uric acid production by inhibiting the activity of xanthine oxidase in serum and liver, while downregulating the levels of renal tissue proteins URAT1 and GLUT9, and upregulating the levels of renal tissue proteins OAT1 and OAT3 to reduce uric acid reabsorption and promote uric acid excretion, thereby achieving the purpose of reducing uric acid levels. Furthermore, the white peony extract is synergistically used with the currently commonly used uric acid-lowering drug allopurinol to develop a more effective and safe uric acid-lowering treatment plan.

The invention relates to the technical field of intelligent eye medicine boxes, and discloses an intelligent eye medicine box and a control method thereof.The eye medicine box is divided into a plurality of compartments for storing different types of medicine, and a sensor is arranged in each compartment to detect the weight of the medicine in real time; and accurately calculating the residual amount of the medicine by combining the initial weight data of the medicine, the dosage of the medicine currently used by the user, the last time of using the medicine by the user, the weight of the medicine in the last time and the total number of times of using the medicine by the user. Furthermore, the future drug use dosage and use rate are predicted through a machine learning model, the remaining amount is optimized based on the prediction results and the real-time weight data, the optimized remaining amount is obtained, and the optimal remaining amount is calculated according to the optimized remaining amount and the future drug use rate. Specifically, firstly, the accuracy of medicine management is remarkably improved through a smoke and flame identification method, it is ensured that a patient can use medicine on time according to the amount, and the poor treatment effect caused by missed taking or wrong taking is avoided;

The invention discloses an anti-inflammatory, antibacterial, itching-relieving and skin-moistening compound composition and a preparation method thereof, and relates to the field of medicines. Comprising the following components in parts by weight: 0.5-2 parts of chlorhexidine acetate, 5-15 parts of radix sophorae flavescentis, 2-8 parts of Chinese prickly ash, 3-10 parts of folium artemisiae argyi, 4-12 parts of cortex phellodendri, 2-6 parts of cortex pseudolaricis, 3-9 parts of fructus kochiae, 1-5 parts of cortex dictamni, 1-4 parts of rhizoma atractylodis, 1-4 parts of radix saposhnikoviae, 2-6 parts of fructus cnidii, 1-5 parts of radix cynanchi paniculati, 0.5-2 parts of borneol, 5-15 parts of aloe and 10-30 parts of propylene glycol. 5-15 parts of tea oil and 1-5 parts of herba violae; according to the anti-inflammatory, antibacterial, itching-relieving and skin-moistening compound composition and the preparation method thereof, various Chinese herbal medicine components are carefully screened and scientifically proportioned, so that the compound composition can remarkably inhibit growth of bacteria and fungi and effectively relieve skin inflammation response, and meanwhile, the excellent itching-relieving and skin-moistening effects are shown.

The invention relates to a crystal form of a compound I, a preparation method of the crystal form, and application of the crystal form in preparation of iron deficiency related treatment medicines for treating anemia accompanied with or not accompanied with iron deficiency. The novel crystal form of the compound I provided by the invention has the advantages of high solubility, good chemical stability, solid stability, mechanical stability and humidity stability, simple preparation method, easiness in crystal form control, low production amplification cost and the like, and has important value for development of the medicine in the future. # imgabs0 #

The invention discloses a fingerprint spectrum construction method of a traditional Chinese medicine composition containing angelica sinensis and cinnamon. The construction method comprises the following steps: preparing a test solution; preparing a reference substance solution; and obtaining the fingerprint spectrum of the traditional Chinese medicine composition according to results of high performance liquid detection of the test solution and the reference solution. The chemical components of the traditional Chinese medicine composition containing angelica sinensis and cinnamon are comprehensively and systematically analyzed, and a theoretical basis is provided for deep research on quality control and pharmacodynamic material basis.

The invention discloses gynecological antibacterial gel aiming at female HPV (human papillomavirus) and a preparation process thereof. The gynecological antibacterial gel is prepared from the following raw materials in parts by weight: 1 to 5 percent of compound fungal polysaccharide, 0.1 to 1 percent of herba centellae extract, 0.1 to 1 percent of coriolus versicolor extract, 0.1 to 1 percent of green tea extract, 0.1 to 0.8 percent of fucoidan polysaccharide sulfate and 0.1 to 1 percent of ginsenoside rg3. The preservative is prepared from, by weight, 0.1%-1% of ginsenoside rg2, 0.1%-1% of betulin, 0.1%-0.5% of sophora flower bud extract, 0.1%-1% of natural silkworm antibacterial peptide, 0.5%-1% of carbomer, 0.1%-0.2% of chlorhexidine gluconate, 3% of glycerinum, 0.6% of xylooligosaccharide, 0.6% of sodium hyaluronate middle molecules, 1.5% of hydrolyzed beta-glucan, 0.6% of 98% D-panthenol, 0.6% of provitamin B5, 0.3% of vitamin C, 0.3% of sodium ascorbate and the balance deionized water. The invention relates to the technical field of gynecological treatment. The composition contains various natural plant extracts and bioactive components, can effectively improve cervical health, can realize effective integration of a microemulsion system and a water phase system during preparation, forms a uniform and stable final product, protects the active components, and ensures the curative effect and product performance.

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a sobering and hangover alleviating traditional Chinese medicine composition which comprises a component A and a component B, wherein the component A comprises a component a, a component b, a component c and a component d; the component B comprises a component e, a component f, a component g and a component h; in the component A, the component a is radix puerariae and an extract thereof; the component b is rhizoma polygonati and an extract thereof; the component c is poria cocos and an extract thereof; the component d is lily and an extract thereof; in the component B, the component e is radix ophiopogonis and an extract thereof; the component f is fructus lycii and an extract thereof; the component g is konjak and an extract thereof; the component h is orange peel and an extract thereof. The eight medicines are combined and can realize synergism, and excellent sobering and hangover alleviating effects can be obtained. The traditional Chinese medicine composition disclosed by the invention can have better sobering and hangover alleviating functions on the basis of the combined action of multiple mechanisms of metabolism acceleration, organ protection and system conditioning, and the components in the traditional Chinese medicine composition all belong to safe raw materials with homology of medicine and food.

The utility model relates to a feeding structure for filling brightening capsule particles in the field of pharmacy, which comprises a feeding funnel, a metering valve seat and a control mechanism, an upper valve block and a lower valve block are arranged in the metering valve seat in a sliding mode, an upper valve hole and a lower valve hole are formed in the middle of the upper valve block, a material supplementing hole is formed in the top of an upper valve cavity, and a feeding hole is formed in the bottom of a lower valve cavity. A metering hole is vertically and coaxially formed between the upper valve cavity and the lower valve cavity, and the upper valve hole and the lower valve hole are alternately communicated with the metering hole; the feeding funnel is connected with a feeding hole of the metering valve seat; the capsule seat is rotationally butted below the feeding hole of the metering valve seat in sequence; the control mechanism comprises a stepping motor and a cam shaft, upper and lower cams opposite in direction are eccentrically mounted on the upper and lower portions of the cam shaft and slidably abut against the upper and lower valve blocks correspondingly, and an upper pressure spring and a lower pressure spring are correspondingly arranged on the right sides of the upper and lower valve blocks. The feeding structure can more accurately control and adjust the filling metering of granular medicine in a single capsule, and the quality and the curative effect of a finished product of the brightening capsule are ensured.

The invention discloses a traditional Chinese medicine composition for treating pressure sores and an oil yarn product and application thereof, and the traditional Chinese medicine composition is characterized by being prepared from the following raw material medicines in parts by weight: 80-120 parts of lithospermum, 40-60 parts of golden cypress, 40-60 parts of scutellaria baicalensis, 40-60 parts of astragalus membranaceus, 30-50 parts of prepared frankincense, 30-50 parts of prepared myrrh and 15-25 parts of pseudo-ginseng powder. The preparation method comprises the following steps: adding sesame oil into a pot, boiling with big fire, turning off the fire, cooling for 1-2 minutes, sequentially adding radix arnebiae seu lithospermi, cortex phellodendri, radix scutellariae, radix astragali, prepared frankincense and prepared myrrh, after all the medicines are completely immersed into the sesame oil, boiling with slow fire for 4-5 minutes, turning off the fire, removing residues, filtering, finally adding pseudo-ginseng powder, and fully stirring and uniformly mixing to obtain the oil preparation for treating the skin ulcers. Use is convenient, and clinical popularization significance is high.

The invention relates to the technical field of drug curative effect monitoring, in particular to wearable drug curative effect monitoring equipment which comprises a wearable garment, two arm sleeves are fixedly connected to the upper portion of the wearable garment, a micro monitoring controller is arranged on one side of the left arm sleeve, and a monitoring operation box is connected to the upper surface of the micro monitoring controller. A blood collecting unit is arranged on the right side of the interior of the monitoring operation box and comprises a linkage box movably arranged in the monitoring operation box, a sealing hole plate is arranged on one side of the linkage box, a sealing piece is slidably arranged on the upper portion of the sealing hole plate in an inserted mode, and a collecting hopper is fixedly connected to the right side of the linkage box; two extraction suction pipes are arranged at the upper end of the collection hopper, so that when a patient goes out, the effect of the medicine in the body can be regulated, controlled and monitored, the overall medicine curative effect is judged in cooperation with comprehensive monitoring of saliva and urine, and the overall medicine curative effect monitoring effect and efficiency are guaranteed.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to the application of a formula for nourishing vital energy and strengthening the body in reducing the toxicity of adjuvant chemotherapy after radical resection of non-small cell lung cancer. This invention discloses a formula for nourishing vital energy and strengthening the body, characterized in that it is composed of the following components by weight: 15-30 parts raw Astragalus membranaceus, 9-21 parts prepared Rehmannia glutinosa, 15-30 parts stir-fried Dioscorea opposita, 9-15 parts Atractylodes macrocephala, 9-15 parts Poria cocos, 15-30 parts raw Coix lacryma-jobi, 9-15 parts Ophiopogon japonicus, 9-15 parts Asparagus cochinchinensis, 15-30 parts Adenophora stricta, 9-15 parts Ligustrum lucidum, 9-15 parts Eclipta prostrata, 9-15 parts stir-fried germinated barley, 9-15 parts stir-fried malt, and 3-6 parts prepared Glycyrrhiza uralensis. This invention can restore vital energy, reverse postoperative weakness, build a foundation for chemotherapy tolerance to reduce toxic side effects, improve chemotherapy tolerance, reduce the risk of interruption to ensure efficacy, improve quality of life during chemotherapy, and help prolong postoperative survival.

The invention belongs to the technical field of medicines, and relates to application of polydocanol in preparation of a medicine for treating lymphatic leakage through a drainage tube or direct puncture application, and the polydocanol is a polydocanol foaming agent. The poly-docanol foaming agent is prepared by rapidly sucking and mixing a liquid preparation containing 5-30 mg of poly-docanol per milliliter and sterile air for 30 times through a three-way cock according to the volume ratio of 1: (1-5), wherein the volume ratio of the liquid preparation to the sterile air is 1: (1-5); the lymphatic leakage is armpit lymphatic leakage caused after breast cancer operation. The invention also provides a treatment method for applying the polydocanol in the lymphatic leakage patient and a medicine for treating the lymphatic leakage, and the medicine comprises the polydocanol and pharmaceutically acceptable auxiliary materials. The method has the advantages of small trauma, simplicity and convenience in operation, high safety, short treatment period, quick response and the like.

This invention provides a fingerprint spectrum of Yishen Wufa Oral Liquid, its construction method, and its application, as well as a multi-index component detection method for Yishen Wufa Oral Liquid, relating to the field of pharmaceutical analysis and structural technology. The fingerprint spectrum of Yishen Wufa Oral Liquid constructed by this invention includes 20 characteristic peaks, including ferulic acid, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, astragaloside A, psoralen, isopsoralen, and emodin. The chromatographic peaks are abundant and attributed to the effective components of psoralen (roasted with black sesame seeds), angelica, poria cocos, wolfberry, fleeceflower root (processed with black bean wine), achyranthes bidentata, and astragalus complanatus. This provides a more comprehensive reflection of the overall chemical composition and quality of Yishen Wufa Oral Liquid, facilitating more effective guidance for feed addition and strict standardization of production operations. It also helps improve the safety and efficacy of Yishen Wufa Oral Liquid in clinical use, possessing high application value.

The application discloses a detection method of Baizhu San standard decoction fingerprint combined with liquid chromatography-mass spectrometry, the fingerprint and application thereof, and belongs to the field of traditional Chinese medicine quality standard research and application. Test sample solution and single control sample solution are injected into a high performance liquid chromatograph to obtain respective chromatograms; mass spectrometry analysis is conducted on the test sample solution to obtain mass spectrometry results; common peaks existing in the chromatogram of the test sample solution are taken as common peaks, chemical components in the Baizhu San standard decoction are identified in combination with the chromatogram of the single control sample solution and the mass spectrometry results of the test sample solution, and the Baizhu San standard decoction fingerprint is obtained. The fingerprint is constructed through liquid chromatography-mass spectrometry, 10 intersecting components are identified in combination with the mass spectrometry information of the control sample, so that the quality control of the Baizhu San standard decoction is realized, the method is simple, easy to operate, high in precision, good in stability and reproducibility, and can effectively solve the technical problem that the quality of the Baizhu San cannot be effectively evaluated.

The present invention discloses a method for constructing a fingerprint of a Chinese medicine composition containing Atractylodes macrocephala, and the method comprises the following steps: preparing a test solution of the Chinese medicine composition; preparing a reference solution; and obtaining a fingerprint of the Chinese medicine composition according to the results of high performance liquid phase detection of the test solution of the Chinese medicine composition and the reference solution. The present invention comprehensively and systematically analyzes the chemical components of the Chinese medicine composition containing Atractylodes macrocephala, and provides a theoretical basis for in-depth research on quality control and the material basis of drug efficacy.

The present invention discloses a method for constructing a fingerprint of a Chinese medicine composition containing Belamcanda chinensis and Ephedra sinica, and the method comprises the following steps: preparing a test solution of the Chinese medicine composition; preparing a reference solution; and obtaining a fingerprint of the Chinese medicine composition according to the results of high performance liquid phase detection of the test solution of the Chinese medicine composition and the reference solution. The present invention comprehensively and systematically analyzes the chemical components of the Chinese medicine composition containing Belamcanda chinensis and Ephedra sinica, and provides a theoretical basis for in-depth research on quality control and the material basis of drug efficacy.

The utility model aims to provide suspension high-shear dispersion preparation mixing equipment which comprises a dispersion machine, a stirring disc is arranged at the bottom of a main shaft, and the stirring disc comprises a second dispersion disc positioned at the bottom end of the main shaft, and a middle guide paddle and a first dispersion disc which are positioned above the second dispersion disc. The utility model relates to the technical field of mixing equipment, and adopts a multi-stirring impeller which combines a first dispersion disc and a second dispersion disc and is provided with a middle guide paddle between the first dispersion disc and the second dispersion disc, so that the stirring mode of a traditional single rectangular tooth dispersion impeller is changed; and the solution is rolled to the upper part by the second dispersion disc to be in contact with the first dispersion disc for secondary shearing. After secondary shearing, the particle size can be further refined, and the distribution is more uniform, so that the dissolution speed and bioavailability of the medicine are improved, and the curative effect of the medicine is ensured. Compared with the traditional equipment that the single-time stirring time is more than 15 minutes, the equipment disclosed by the utility model can obviously reduce the single-time stirring time.

The invention discloses a preparation method of a florfenicol composite drug, and belongs to the technical field of pharmaceutical preparations, the preparation method comprises the following steps: adding florfenicol into a chitosan solution, and attaching the florfenicol to chitosan to form a precursor compound; then an arthrospira sulfated polysaccharide extract is added into the precursor compound, due to the binding force between the arthrospira sulfated polysaccharide extract and chitosan, composite particles coated with florfenicol are formed, and the arthrospira sulfated polysaccharide extract is located on the periphery of the composite particles, so that the composite particles are hydrophilic and carry negative charges; the composite particles coated with the florfenicol are the florfenicol composite medicine. According to the scheme, the use variety of drugs is reduced, the compound drug integrates multiple treatment functions into one drug, the variety of drugs needing to be taken by a patient at the same time is reduced, and the treatment scheme is simplified. According to the scheme, the florfenicol hydrogel has the characteristics of biocompatibility and degradability, the water solubility of florfenicol is improved, the reaction process is very simple, and the florfenicol hydrogel is suitable for industrial production.

The invention discloses a method for detecting polymers in cefoperazone sodium and sulbactam sodium, and belongs to the technical field of medicine quality control. The invention discloses a method for detecting polymers in cefoperazone sodium and sulbactam sodium. Respectively injecting the test solution and the reference solution into a liquid chromatograph, and detecting the content of the polymer by adopting a high performance liquid chromatography; the chromatographic column is a reversed-phase liquid chromatographic column; the detection wavelength is 240 to 250 nm; the flow velocity of the mobile phase is 0.4-0.8 ml / min; the column temperature is 20-30 DEG C; according to the method, the content of the polymer can be directly tested in one step under the chromatographic condition through liquid chromatography detection, and compared with the prior art in which impurities and main components are separated through a one-dimensional detection method and then the impurities are subjected to two-dimensional chromatographic analysis, the method is simple and high in operability and has remarkable advantages; the method can meet the requirements of qualitative and quantitative analysis, and is good in reproducibility, high in specificity, strong in durability, high in detection accuracy and good in system adaptability.

The invention provides a construction method and a quality detection method of a characteristic spectrum of a traditional Chinese medicine composition, and the construction method of the characteristic spectrum comprises the following steps: taking a solution of a traditional Chinese medicine composition test sample and a solution of a reference substance, and carrying out high performance liquid chromatography detection to obtain the characteristic spectrum of the traditional Chinese medicine composition; wherein the traditional Chinese medicine composition comprises radix scutellariae, cortex mori radicis, fructus trichosanthis, semen armeniacae amarae, radix adenophorae, radix ophiopogonis, semen coicis, semen benincasae, fructus aurantii, radix curcumae, rhizoma imperatae, radix salviae miltiorrhizae, indigo naturalis and clam shells; the liquid chromatographic analysis conditions of the detection are as follows: octadecylsilane chemically bonded silica is used as a filler, acetonitrile is used as a mobile phase A, a phosphoric acid solution with the volume percentage of 0.09-0.11% is used as a mobile phase B, gradient elution is performed, the detection wavelength is 207-286nm, the column temperature is 25-35 DEG C, and the flow velocity is 0.9-1.1 mL / min. The specific chromatogram constructed by the invention can objectively evaluate the quality of a traditional Chinese medicine composition sample and improve the quality of the traditional Chinese medicine composition, so that the curative effect is ensured.

The invention provides a characteristic spectrum construction method and application of compound basil granules, and a quality detection method and a multi-index component detection method of the compound basil granules, and relates to the technical field of traditional Chinese medicine detection. The specific chromatogram of the compound basil granules provided by the invention comprises 13 known substances, namely the characteristic peaks of gallic acid, neochlorogenic acid, chlorogenic acid, caffeic acid, rutin, hyperoside, isoquercitrin, rosmarinic acid, luteolin, apigenin, kaempferol, lysionotin and nardosinone. The method overcomes the defect that the quality of related dosage forms cannot be detected from multiple angles in all directions due to interference caused by complex chemical components of the compound basil granules, provides a basis for quality control of the compound basil granules, and is verified by methodology to be good in reproducibility and stability, reliable in recovery rate, low in detection cost, high in detection efficiency and suitable for popularization and application. The method plays a crucial role in the quality stability of the compound basil granule product.

The invention discloses a pharmaceutical composition containing omega-3 fatty acid and statins and a preparation method of the pharmaceutical composition, and belongs to the technical field of preparation of pharmaceutical compositions. The preparation method comprises the following steps: dissolving the film-forming material in a solvent, adding the statins, the plasticizer and the stabilizer into the solvent to prepare an upper drug layer coating solution, adjusting coating parameters, and preparing an upper drug layer coating outside the capsule core by using the upper drug layer coating solution, or additionally coating a protective layer coating outside the upper drug layer coating to complete the preparation of the composition. The pharmaceutical composition prepared by the invention is of a capsule core / upper drug layer coating structure or a capsule core / upper drug layer coating / protective layer coating structure, and compared with a composition of a capsule core / isolating layer coating / upper drug layer coating structure or a capsule core / isolating layer coating / upper drug layer coating / protective layer coating structure, the pharmaceutical composition has the advantages that the content of the pharmaceutical composition is reduced; the pharmaceutical composition which is not coated with the isolating layer coating is more stable, quick release of omega-3 fatty acid and statins can be realized after stable lofting, the curative effect of drug combination is ensured, and the purpose of synergistically reducing blood fat can be efficiently achieved.

The invention belongs to the technical field of traditional Chinese medicine analysis, and particularly relates to a construction method and application of a specific chromatogram of an achyranthes aspera throat-clearing mixture. According to the invention, the spanning from single index control to overall quality evaluation is realized; the specific characteristic spectrum method for the achyranthes aspera throat-clearing mixture is established for the first time, and the limitation that only the content of a single component is measured in the prior art is broken through. By simultaneously monitoring the five key characteristic peaks of chlorogenic acid, caffeic acid, bergenin, geniposide and catechin and the consistency of the overall spectrum of the five key characteristic peaks, the basic material feeding condition and the matching stability of the monarch, minister, assistant and guide medicines in the preparation can be comprehensively reflected, so that the overall quality and the uniformity of the curative effect of the product are more scientifically guaranteed.

The invention relates to the technical field of traditional Chinese medicine quality control, in particular to a quality control method of a traditional Chinese medicine composition capable of relieving pain and numbness. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 2-8 parts of caulis spatholobi, 3-10 parts of rhizoma corydalis, 4-10 parts of caulis sinomenii, 2-5 parts of frankincense, 2-8 parts of radix zanthoxyli, 2-7 parts of ligusticum wallichii, 1-6 parts of sappan wood, 0.5-3 parts of borneol, 3-9 parts of turmeric, 1-7 parts of radix achyranthis bidentatae, 0.5-4 parts of pepper and 1-5 parts of cassia twig. A mobile phase A (acetonitrile)-B (0.1% phosphoric acid aqueous solution) is used for gradient elution, and triethylamine is used for adjusting pH. The sample quality control method which is good in specificity, high in separation degree and good in accuracy is obtained by optimizing preparation conditions and chromatographic conditions of a test solution, and the method is suitable for quality control of the traditional Chinese medicine composition capable of relieving pain and numbness.

The utility model relates to the technical field of medical fixing devices, in particular to a head treatment fixator which comprises a combined fixing device and a fixing racket, and a lower jaw supporting piece and a front chest supporting fixator are arranged on the upper portion and the lower portion of the surface of one side of a fixator knob respectively. A telescopic rod piece is arranged on the surface of the top end of the tightening knob, a suction cup assembly is arranged on the surface of one end of the telescopic rod piece, and the lower jaw and the headrest part are supported to help a patient to fix the head and prevent the head from moving left and right and front and back; a simple device capable of pressurizing and fixing the treatment bat by screwing is configured, so that the treatment bat and the like are tightly attached to the treatment part of the head, dislocation of the head and the bat is further prevented, it is guaranteed that the bat stimulates the same site, the curative effect is guaranteed, the work of manually fixing the bat and the head by family members of a patient is liberated, and the overall using and fixing efficiency is improved.

The invention discloses a levofloxacin hapten, antigen and antibody as well as a preparation method and application thereof, and belongs to the technical field of small molecule immunodetection.A flexible spacer-(CH2) n-NH2 containing a terminal amino group is introduced to a nitrogen atom (namely a methyl connection site of methyl piperazine) at the tail end of a piperazine ring of a levofloxacin molecule, n is an integer of 2-8, and the flexible spacer-(CH2) n-NH2 is introduced into the nitrogen atom at the tail end of the piperazine ring of the levofloxacin molecule; therefore, a complete antigen with high immunogenicity and high specificity is constructed on the premise that a complete pharmacological structure of a quinolone mother nucleus is reserved, and a high-affinity antibody aiming at levofloxacin is obtained through induction.

The invention discloses a processing technology for removing aristolochic acid in medicinal materials, and relates to the technical field of traditional Chinese medicine processing, and the technical scheme is as follows: the processing technology comprises the following steps: S1, taking crude medicinal materials, and crushing the crude medicinal materials at room temperature to obtain medicinal material powder; s2, heating and processing the medicinal material powder prepared in the step S1 in a drying oven, taking out the medicinal material powder after processing is finished, and cooling to obtain a medicinal material processed product. According to the processing technology, the content of aristolochic acid in the medicinal materials can be better reduced, meanwhile, active ingredients of the medicinal materials are not damaged, and the curative effect of the traditional Chinese medicine is ensured. The medicinal material containing aristolochic acid is processed by heating, so that on one hand, the effect of reducing toxicity can be achieved, and on the other hand, other auxiliary materials are not added to influence the components of the traditional Chinese medicine. The processing period is short, the processing technology is simple and easy to operate, and industrial production can be achieved.

The invention discloses a traditional Chinese medicine composition for treating wind-cold-dampness arthralgia type lumbago and application thereof. The traditional Chinese medicine composition is prepared by extracting the following raw materials in parts by weight: 20 to 40 parts of radix stephaniae tetrandrae, 20 to 40 parts of radix clematidis, 5 to 15 parts of radix angelicae sinensis, 5 to 15 parts of rhizoma chuanxiong, 20 to 40 parts of fructus chaenomelis, 5 to 15 parts of fructus foeniculi, 5 to 15 parts of frankincense, 20 to 40 parts of herba lycopodii, 5 to 15 parts of lignum sappan, 5 to 15 parts of borneol, 5 to 15 parts of menthol and 20 to 40 parts of vaseline. The traditional Chinese medicine composition has the effects of dispelling cold and wind, eliminating dampness, regulating qi and blood, warming and activating meridians and relieving swelling and pain, clinical experiments show that the traditional Chinese medicine composition can obviously improve clinical symptoms of patients with wind-cold-dampness arthralgia type lumbago and has high clinical application value in the aspect of treating wind-cold-dampness arthralgia type lumbago.

The invention discloses application of RYK and a ligand-receptor signal axis inhibitor thereof in preparation of medicines for treating fatty liver diseases and pulmonary fibrosis, in the technical scheme provided by the invention, the RYK receptor is found and verified as a functional receptor of a secretory extracellular domain (G-ECD) of glycoprotein non-metastatic melanoma protein B for the first time; it is revealed that a G-ECD-RYK signal axis is a key mechanism for driving occurrence and development of metabolic dysfunction related fatty liver diseases / hepatitis (MASLD / MASH) and pulmonary fibrosis. According to the invention, the ligand G-ECD of the RYK is found, and the ligand-receptor signal axis of the RYK is determined to be a brand new drug target with high specificity.