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1150results about How to "Guaranteed curative effect" patented technology

Metformin hydrochloride enteric-coated tablets quality control method

The invention discloses a quality control method of metformin hydrochloride enteric coated tablet, comprising the aspects of character, identification, examination and content measurement; wherein, release examination comprises the release quantity examination of acid in hydrochloric acid solution of 0.1 mol/l and the release quantity examination in phosphate buffer with the pH value of 6.8; the examination of relevant substances comprises the following steps: dicyandiamide is taken as reference, sulfonic group cation exchange bonded silica is taken as filler, ammonium dihydrogen phosphate solution of 1.7 percent with the pH value of 3 is mobile phase and the high performance liquid chromatography is used for examining the relevant substances. The invention controls the release quantity of the metformin hydrochloride enteric coated tablet in gastric juice strictly, reduces the adverse reaction of patients effectively, improves the release quantity of the metformin hydrochloride enteric coated tablet in the buffer solution (simulated intestinal juice) and ensures the dissolution of the enteric coated tablet in the intestinal juice effectively; the invention also adds the examination of dicyandiamide impurity under the examination item and enhances the safety of the medicine.
Owner:贵州天安药业股份有限公司

Health-care food capsule and preparation method thereof

The invention provides a health-care food capsule, which consists of a content and a gelatine skin, wherein the content is a mixture which is prepared from raw materials according to the following part by weight: 12-22 of maca powder, 5-15 of wolfberry extract, 5-15 of Chinese angelica extract, 2-8 of acanthopanax extract, 2-8 of epimedium extract, 1-5 of ginseng extract, 15-25 of corn oil and 35-50 of tea seed oil. The gelatine skin is prepared from edible gelatine, glycerin and purified water according to the weight ratio of 1/1/0.5. The content is obtained through crushing, burdening, mixing, grinding and degassing the raw materials. The gelatine skin takes the edible gelatine, the glycerin and the purified water as gelatine skin raw materials, the gelatine liquor is obtained after mixing, gelating and heating the gelatine skin raw materials,, then the content and the gelatine liquor in the capsule are produced through the pelleting of an automated machine, and a product has a reasonable and practicable processing method. The health-care food capsule has the effects of alleviating climacteric syndrome, increasing the sexual capacity and relieving physical fatigue, is easy to beabsorbed by the human body, has no toxic and side effects, and can be orally taken for a long time.
Owner:厦门鹰君药业有限公司

Portable blood purifying system

The invention relates to a portable blood purifying system, which comprises a high throughput dialyzer with an arterial duct, a venous duct, a washing liquid tube and a transfusion tube; the arterial duct is in turn connected in series with an arterial valve, an arterial pressure sensor and a blood pump; the venous duct is in turn connected in series with a venous valve, a venous temperature sensor, a venous bubble detector and a venous pressure sensor, so that an external circulation unit is formed; the washing liquid tube is connected in series with a pre-charging valve and is communicated with a washing liquid container; the transfusion tube is in turn connected in series with a temperature controller, a transfusion tube bubble collector and a transfusion pump, and is communicated with a waste liquid container, so that a waste liquid processing unit is formed; and the system also comprises a transfusion pump, a temperature control device, a transfusion tube, a gating valve and a first transfusion branch and a second transfusion tube branch, so that a transfusion unit is formed. The system is simplified in structure and convenient to carry; and the system is suitable for patients to do short-time dialysis for several times or night dialysis treatment at home as household treatment equipment, so that toxin tolerance of dialysis patients during dialysis period is relieved while medical cost is reduced.
Owner:黄昱

Quality control method of total glycosides single preparation of white paeony roots

The invention provides a quality control method of a preparation of white paeony roots. The method comprises the following steps of: establishing a synchronous content measuring method of white paeony root herbs, white paeony root total glycosides and paeoniflorin and albiflorin in the white paeony root preparation by adopting the same liquid-phase chromatography condition; and accurately measuring the contents of the paeoniflorin and the albiflorin. The method is simple to preprocess a sample, keeps complete characteristic components and provides a stable sample solution and has higher accuracy, favorable reproduction and a certain specificity; characteristic peaks in the obtained fingerprint map have favorable separation effect, the fingerprint maps of the white paeony root herbs, the white paeony root total glycosides and the preparation have favorable relativity; the standard fingerprint map of the white paeony root herbs is established at a new angle by utilizing the relativity research of the fingerprint maps, can be used for identifying the qualities of the white paeony root herbs and improving the controllability of the production process of the white paeony root preparation and is favorable to ensuring the quality stability and the clinical curative effect of the white paeony root preparation.
Owner:NINGBO LIWAH PHARM CO LTD

Shenqi hypoglycemic preparation HPLC standard finger print and construction method thereof

The present invention discloses a Shenqi hypoglycemic preparation HPLC standard finger print and a construction method thereof. The construction method comprises the following steps: preparing test sample solutions and a reference solution, measuring the test sample solutions and the reference solution by using the HPLC method and the linear gradient elution process, so as to obtain the Shenqi hypoglycemic preparation finger prints, wherein the chromatographic condition is that a mobile phase A is acetonitrile, a mobile phase B is 0.1% (v/v) phosphoric acid solution, the detection wavelength is 203nm, the column temperature is 25-35 DEG C and the flow rate is 0.8-1.2mL/min. The common characteristic peaks of at least ten finger prints are used as the characteristic peaks of the standard finger print; the standard finger print comprises 38 characteristic peaks, and the numbers of the characteristic peaks of saponin of ginseng stem and leaf, astragalus, Chinese magnoliaving, rehmannia root and raspberry are 13, 4, 7, 3 and 4 respectively. The Shenqi hypoglycemic preparation HPLC standard finger print and the construction method thereof can comprehensively and accurately evaluate the whole quality of the Shenqi hypoglycemic preparation, and facilitate to ensure the quality and the clinical curative effect of the Shenqi hypoglycemic preparation.
Owner:广东万年青制药股份有限公司

Lyophilized viper antivenin and preparation method thereof

The invention discloses a lyophilized viper antivenin and a preparation method thereof, belonging to biochemical products, more particularly relating to an antivenin and a preparation technology thereof. The mass ratio of the antivenin and viper venom is 15:1, which can specifically neutralize the viper venom injected to mouse; as determined by immunodiffusion, the immunoprecipitation line appears in case that the ratio of viper antivenin F(ab')2 in lyophilized form to viper venom is 8:1; and other detected items conform to the quality standard of antivenin in Chinese Pharmacopoeia 2010. The detection of Phenyl-Sepharose (low-sub) FF column chromatography result shows that: activity is centralized at eluting peak 1, micromolecule impurity proteins are centralized at penetration peal, eluting peak 2 and eluting peak 3. According to the technology of the invention, immune blood plasma is resulted from viper venom immune horse, IgG is prepared by salting out the immune blood plasma, and F(ab')2 active fragment is obtained after the IgG is subject to enzymolysis and purification by a hydrophobic column. The lyophilized viper antivenin has strong specificity, high potency and more than 85% of the purity of antivenin F(ab')2 in lyophilized form.
Owner:浙江健博生物科技股份有限公司

Six-flavor hematinic capsule, its quality control method and application thereof

The invention discloses a six-flavor hematinic capsule, its quality control method and an application thereof. The six-flavor hematinic capsule is prepared by adding auxiliary materials into raw materials consisting of Chinese angelica, Ligusticum wallichii, Radix Astragali, prepared rehmannia root, lithospermum and white peony root. According to the quality control method of the six-flavor hematinic preparation, whether the six-flavor hematinic capsule contains white peony root, Chinese angelica, Radix Astragali, prepared rehmannia root, lithospermum, Ligusticum wallichii and components is identified by thin layer chromatography; by high-performance liquid chromatography, in vitro dissolution behavior of the six-flavor hematinic capsule is determined, and effective component groups are identified by fingerprint; verbascoside and calycosin glucoside are used as reference substances to simultaneously determine contents in the six-flavor hematinic capsule; and the content of a volatile component ligustilide in the six-flavor hematinic capsule is determined by a gas chromatographic method. The method provided by the invention is simple to operate, is accurate and advanced, has good linear relation, reappearance, precision, stability and recovery rate, can be adopted to effectively control product quality and guarantee curative effect of the product. The invention also provides an application in the preparation of a medicine for treating eye damage and blurred vision.
Owner:GUANGDONG GUOYUAN GUOYAO PHARMA CO LTD

Method for detecting Jingfang granules

The invention relates to a method for detecting Jingfang granules. The method comprises the steps of character identifying, checking and measuring content, wherein the step of identifying comprises identification of schizonepeta, radix angelicae pubescentis, ligusticum wallichii, fructus aurantii and bupleurum longiradiatum; the step of measuring content refers to a step of measuring content of ephedrine hydrochloride. Aiming at the problem that the condition that fewer raw materials are added or corresponding raw materials are not added by illegal manufacturer or a counterfeit drug bupleurum longiradiatum is mixed cannot be monitored because active ingredients of the granules cannot be correspondingly detected by a set of perfect detection method at present, a scientific, reasonable, practical and feasible component identification and content measurement method is formulated, the clinical effects of the Jingfang granules are guaranteed, quality indexes of several medicinal materials are clear, and application of various medicinal materials in the Jingfang granules is ensured, so that the curative effect of the drug is guaranteed. Moreover, the counterfeit drug bupleurum longiradiatum in radix bupleuri can be effectively detected, and a phenomenon that health of patients is endangered by two toxic ingredients, including bupleurotoxin and acetylbupleurotoxin, contained in bupleurum longiradiatum is avoided.
Owner:九寨沟天然药业股份有限公司

Detection method of common goldenrop particles

InactiveCN103954723AQuality reflectionEasy to useComponent separationBupleurum longiradiatumClinical efficacy
The invention relates to a detection method of common goldenrop particles. The detection method comprises inspection items of identifying characters and measuring content. The identification item comprises identification of scutellaria baicalensis, identification of liquorice, identification of radix bupleuri and identification of bupleurum longiradiatum; the item of measuring content is used for measuring the content of baicalin. In order to solve the problem of incapability of monitoring insufficiency or absence of corresponding raw materials of illegal manufacturers and monitoring the interfusion of bupleurum longiradiatum caused by the lack of one set of complete detection method for detecting active ingredients of common goldenrop particles at present, the method disclosed by the invention can be used for identifying components and measuring content scientifically, reasonably and feasibly; the method is capable of guaranteeing the clinical efficacy of common goldenrop particles, making clear quality indexes of several medicine materials and guaranteeing the use of all medicine materials in the common goldenrop particles, thereby guaranteeing the curative effect of the common goldenrop particles; in addition, bupleurum longiradiatum serving as a counterfeit drug of radix bupleuri can also be effectively detected, thereby avoiding the damage to the health of patients caused by two toxic ingredients comprising radix bupleuri toxin and acetyl radix bupleuri toxin in bupleurum longiradiatum.
Owner:SICHUAN FENGCHUN PHARMA
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